Found 74 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340502
(CHEMBL1762178 | N-(4-((5,5-dimethyl-2,4-dioxo-3-(4...)Show SMILES CC(=O)Nc1cc(CN2C(=O)N(C(=O)C2(C)C)c2ccc(SC(F)(F)F)cc2)ccn1 Show InChI InChI=1S/C20H19F3N4O3S/c1-12(28)25-16-10-13(8-9-24-16)11-26-18(30)27(17(29)19(26,2)3)14-4-6-15(7-5-14)31-20(21,22)23/h4-10H,11H2,1-3H3,(H,24,25,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description
Inhibition of autophosphosphorylation of human IGF1R expressed in IGF1-stimulated MCF7 cells preincubated for 60 mins by ELISA |
Bioorg Med Chem Lett 21: 2224-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340502
(CHEMBL1762178 | N-(4-((5,5-dimethyl-2,4-dioxo-3-(4...)Show SMILES CC(=O)Nc1cc(CN2C(=O)N(C(=O)C2(C)C)c2ccc(SC(F)(F)F)cc2)ccn1 Show InChI InChI=1S/C20H19F3N4O3S/c1-12(28)25-16-10-13(8-9-24-16)11-26-18(30)27(17(29)19(26,2)3)14-4-6-15(7-5-14)31-20(21,22)23/h4-10H,11H2,1-3H3,(H,24,25,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description
Inhibition of autophosphosphorylation of human IGF1R expressed in IGF1-stimulated MCF7 cells by ELISA |
Bioorg Med Chem Lett 21: 2224-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340502
(CHEMBL1762178 | N-(4-((5,5-dimethyl-2,4-dioxo-3-(4...)Show SMILES CC(=O)Nc1cc(CN2C(=O)N(C(=O)C2(C)C)c2ccc(SC(F)(F)F)cc2)ccn1 Show InChI InChI=1S/C20H19F3N4O3S/c1-12(28)25-16-10-13(8-9-24-16)11-26-18(30)27(17(29)19(26,2)3)14-4-6-15(7-5-14)31-20(21,22)23/h4-10H,11H2,1-3H3,(H,24,25,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in baculovirus-SF21 cell system preincubated for 60 mins by tim... |
Bioorg Med Chem Lett 21: 2224-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340502
(CHEMBL1762178 | N-(4-((5,5-dimethyl-2,4-dioxo-3-(4...)Show SMILES CC(=O)Nc1cc(CN2C(=O)N(C(=O)C2(C)C)c2ccc(SC(F)(F)F)cc2)ccn1 Show InChI InChI=1S/C20H19F3N4O3S/c1-12(28)25-16-10-13(8-9-24-16)11-26-18(30)27(17(29)19(26,2)3)14-4-6-15(7-5-14)31-20(21,22)23/h4-10H,11H2,1-3H3,(H,24,25,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in baculovirus-SF21 cell system preincubated for 30 mins by tim... |
Bioorg Med Chem Lett 21: 2224-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340513
(2-(5,6-dimethoxy-1-methyl-1H-indol-3-yl)-1H-pyrrol...)Show InChI InChI=1S/C18H17N3O2/c1-21-10-13(14-7-11-5-4-6-19-18(11)20-14)12-8-16(22-2)17(23-3)9-15(12)21/h4-10H,1-3H3,(H,19,20) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in baculovirus-SF21 cell system preincubated for 30 mins by tim... |
Bioorg Med Chem Lett 21: 2224-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340513
(2-(5,6-dimethoxy-1-methyl-1H-indol-3-yl)-1H-pyrrol...)Show InChI InChI=1S/C18H17N3O2/c1-21-10-13(14-7-11-5-4-6-19-18(11)20-14)12-8-16(22-2)17(23-3)9-15(12)21/h4-10H,1-3H3,(H,19,20) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 34 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in baculovirus-SF21 cell system preincubated for 10 mins by tim... |
Bioorg Med Chem Lett 21: 2224-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340513
(2-(5,6-dimethoxy-1-methyl-1H-indol-3-yl)-1H-pyrrol...)Show InChI InChI=1S/C18H17N3O2/c1-21-10-13(14-7-11-5-4-6-19-18(11)20-14)12-8-16(22-2)17(23-3)9-15(12)21/h4-10H,1-3H3,(H,19,20) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 34 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in baculovirus-SF21 cell system preincubated for 5 mins by time... |
Bioorg Med Chem Lett 21: 2224-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340503
(1-((2-aminopyridin-4-yl)methyl)-5,5-dimethyl-3-(4-...)Show SMILES CC1(C)N(Cc2ccnc(N)c2)C(=O)N(C1=O)c1ccc(SC(F)(F)F)cc1 Show InChI InChI=1S/C18H17F3N4O2S/c1-17(2)15(26)25(12-3-5-13(6-4-12)28-18(19,20)21)16(27)24(17)10-11-7-8-23-14(22)9-11/h3-9H,10H2,1-2H3,(H2,22,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 34 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description
Inhibition of autophosphosphorylation of human IGF1R expressed in IGF1-stimulated MCF7 cells by ELISA |
Bioorg Med Chem Lett 21: 2224-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340513
(2-(5,6-dimethoxy-1-methyl-1H-indol-3-yl)-1H-pyrrol...)Show InChI InChI=1S/C18H17N3O2/c1-21-10-13(14-7-11-5-4-6-19-18(11)20-14)12-8-16(22-2)17(23-3)9-15(12)21/h4-10H,1-3H3,(H,19,20) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in baculovirus-SF21 cell system preincubated for 60 mins by tim... |
Bioorg Med Chem Lett 21: 2224-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340500
(5,5-dimethyl-1-((2-(methylamino)pyridin-4-yl)methy...)Show SMILES CNc1cc(CN2C(=O)N(C(=O)C2(C)C)c2ccc(SC(F)(F)F)cc2)ccn1 Show InChI InChI=1S/C19H19F3N4O2S/c1-18(2)16(27)26(13-4-6-14(7-5-13)29-19(20,21)22)17(28)25(18)11-12-8-9-24-15(10-12)23-3/h4-10H,11H2,1-3H3,(H,23,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description
Inhibition of autophosphosphorylation of human IGF1R expressed in IGF1-stimulated MCF7 cells by ELISA |
Bioorg Med Chem Lett 21: 2224-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340501
(1-((2-(ethylamino)pyridin-4-yl)methyl)-5,5-dimethy...)Show SMILES CCNc1cc(CN2C(=O)N(C(=O)C2(C)C)c2ccc(SC(F)(F)F)cc2)ccn1 Show InChI InChI=1S/C20H21F3N4O2S/c1-4-24-16-11-13(9-10-25-16)12-26-18(29)27(17(28)19(26,2)3)14-5-7-15(8-6-14)30-20(21,22)23/h5-11H,4,12H2,1-3H3,(H,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 47 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description
Inhibition of autophosphosphorylation of human IGF1R expressed in IGF1-stimulated MCF7 cells by ELISA |
Bioorg Med Chem Lett 21: 2224-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340513
(2-(5,6-dimethoxy-1-methyl-1H-indol-3-yl)-1H-pyrrol...)Show InChI InChI=1S/C18H17N3O2/c1-21-10-13(14-7-11-5-4-6-19-18(11)20-14)12-8-16(22-2)17(23-3)9-15(12)21/h4-10H,1-3H3,(H,19,20) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assay |
Bioorg Med Chem Lett 21: 2224-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340502
(CHEMBL1762178 | N-(4-((5,5-dimethyl-2,4-dioxo-3-(4...)Show SMILES CC(=O)Nc1cc(CN2C(=O)N(C(=O)C2(C)C)c2ccc(SC(F)(F)F)cc2)ccn1 Show InChI InChI=1S/C20H19F3N4O3S/c1-12(28)25-16-10-13(8-9-24-16)11-26-18(30)27(17(29)19(26,2)3)14-4-6-15(7-5-14)31-20(21,22)23/h4-10H,11H2,1-3H3,(H,24,25,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 87 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in baculovirus-SF21 cell system preincubated for 10 mins by tim... |
Bioorg Med Chem Lett 21: 2224-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340503
(1-((2-aminopyridin-4-yl)methyl)-5,5-dimethyl-3-(4-...)Show SMILES CC1(C)N(Cc2ccnc(N)c2)C(=O)N(C1=O)c1ccc(SC(F)(F)F)cc1 Show InChI InChI=1S/C18H17F3N4O2S/c1-17(2)15(26)25(12-3-5-13(6-4-12)28-18(19,20)21)16(27)24(17)10-11-7-8-23-14(22)9-11/h3-9H,10H2,1-2H3,(H2,22,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 92 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assay |
Bioorg Med Chem Lett 21: 2224-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340503
(1-((2-aminopyridin-4-yl)methyl)-5,5-dimethyl-3-(4-...)Show SMILES CC1(C)N(Cc2ccnc(N)c2)C(=O)N(C1=O)c1ccc(SC(F)(F)F)cc1 Show InChI InChI=1S/C18H17F3N4O2S/c1-17(2)15(26)25(12-3-5-13(6-4-12)28-18(19,20)21)16(27)24(17)10-11-7-8-23-14(22)9-11/h3-9H,10H2,1-2H3,(H2,22,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 92 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells after 10 mins by time resolved-fluorescent assay |
Bioorg Med Chem Lett 21: 2224-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340502
(CHEMBL1762178 | N-(4-((5,5-dimethyl-2,4-dioxo-3-(4...)Show SMILES CC(=O)Nc1cc(CN2C(=O)N(C(=O)C2(C)C)c2ccc(SC(F)(F)F)cc2)ccn1 Show InChI InChI=1S/C20H19F3N4O3S/c1-12(28)25-16-10-13(8-9-24-16)11-26-18(30)27(17(29)19(26,2)3)14-4-6-15(7-5-14)31-20(21,22)23/h4-10H,11H2,1-3H3,(H,24,25,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 98 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assay |
Bioorg Med Chem Lett 21: 2224-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340502
(CHEMBL1762178 | N-(4-((5,5-dimethyl-2,4-dioxo-3-(4...)Show SMILES CC(=O)Nc1cc(CN2C(=O)N(C(=O)C2(C)C)c2ccc(SC(F)(F)F)cc2)ccn1 Show InChI InChI=1S/C20H19F3N4O3S/c1-12(28)25-16-10-13(8-9-24-16)11-26-18(30)27(17(29)19(26,2)3)14-4-6-15(7-5-14)31-20(21,22)23/h4-10H,11H2,1-3H3,(H,24,25,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 98 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells after 10 mins by time resolved-fluorescent assay |
Bioorg Med Chem Lett 21: 2224-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340514
(5,5-dimethyl-1-(pyridin-4-ylmethyl)-3-(4-(trifluor...)Show SMILES CC1(C)N(Cc2ccncc2)C(=O)N(C1=O)c1ccc(SC(F)(F)F)cc1 Show InChI InChI=1S/C18H16F3N3O2S/c1-17(2)15(25)24(13-3-5-14(6-4-13)27-18(19,20)21)16(26)23(17)11-12-7-9-22-10-8-12/h3-10H,11H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 117 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description
Inhibition of autophosphosphorylation of human IGF1R expressed in IGF1-stimulated MCF7 cells by ELISA |
Bioorg Med Chem Lett 21: 2224-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340513
(2-(5,6-dimethoxy-1-methyl-1H-indol-3-yl)-1H-pyrrol...)Show InChI InChI=1S/C18H17N3O2/c1-21-10-13(14-7-11-5-4-6-19-18(11)20-14)12-8-16(22-2)17(23-3)9-15(12)21/h4-10H,1-3H3,(H,19,20) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 145 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description
Inhibition of autophosphosphorylation of human IGF1R expressed in IGF1-stimulated MCF7 cells by ELISA |
Bioorg Med Chem Lett 21: 2224-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340501
(1-((2-(ethylamino)pyridin-4-yl)methyl)-5,5-dimethy...)Show SMILES CCNc1cc(CN2C(=O)N(C(=O)C2(C)C)c2ccc(SC(F)(F)F)cc2)ccn1 Show InChI InChI=1S/C20H21F3N4O2S/c1-4-24-16-11-13(9-10-25-16)12-26-18(29)27(17(28)19(26,2)3)14-5-7-15(8-6-14)30-20(21,22)23/h5-11H,4,12H2,1-3H3,(H,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 154 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assay |
Bioorg Med Chem Lett 21: 2224-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340501
(1-((2-(ethylamino)pyridin-4-yl)methyl)-5,5-dimethy...)Show SMILES CCNc1cc(CN2C(=O)N(C(=O)C2(C)C)c2ccc(SC(F)(F)F)cc2)ccn1 Show InChI InChI=1S/C20H21F3N4O2S/c1-4-24-16-11-13(9-10-25-16)12-26-18(29)27(17(28)19(26,2)3)14-5-7-15(8-6-14)30-20(21,22)23/h5-11H,4,12H2,1-3H3,(H,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 154 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells after 10 mins by time resolved-fluorescent assay |
Bioorg Med Chem Lett 21: 2224-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340502
(CHEMBL1762178 | N-(4-((5,5-dimethyl-2,4-dioxo-3-(4...)Show SMILES CC(=O)Nc1cc(CN2C(=O)N(C(=O)C2(C)C)c2ccc(SC(F)(F)F)cc2)ccn1 Show InChI InChI=1S/C20H19F3N4O3S/c1-12(28)25-16-10-13(8-9-24-16)11-26-18(30)27(17(29)19(26,2)3)14-4-6-15(7-5-14)31-20(21,22)23/h4-10H,11H2,1-3H3,(H,24,25,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 175 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in baculovirus-SF21 cell system preincubated for 5 mins by time... |
Bioorg Med Chem Lett 21: 2224-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340513
(2-(5,6-dimethoxy-1-methyl-1H-indol-3-yl)-1H-pyrrol...)Show InChI InChI=1S/C18H17N3O2/c1-21-10-13(14-7-11-5-4-6-19-18(11)20-14)12-8-16(22-2)17(23-3)9-15(12)21/h4-10H,1-3H3,(H,19,20) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description
Inhibition of autophosphosphorylation of human IGF1R expressed in IGF1-stimulated MCF7 cells preincubated for 60 mins by ELISA |
Bioorg Med Chem Lett 21: 2224-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340500
(5,5-dimethyl-1-((2-(methylamino)pyridin-4-yl)methy...)Show SMILES CNc1cc(CN2C(=O)N(C(=O)C2(C)C)c2ccc(SC(F)(F)F)cc2)ccn1 Show InChI InChI=1S/C19H19F3N4O2S/c1-18(2)16(27)26(13-4-6-14(7-5-13)29-19(20,21)22)17(28)25(18)11-12-8-9-24-15(10-12)23-3/h4-10H,11H2,1-3H3,(H,23,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 202 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells after 10 mins by time resolved-fluorescent assay |
Bioorg Med Chem Lett 21: 2224-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340500
(5,5-dimethyl-1-((2-(methylamino)pyridin-4-yl)methy...)Show SMILES CNc1cc(CN2C(=O)N(C(=O)C2(C)C)c2ccc(SC(F)(F)F)cc2)ccn1 Show InChI InChI=1S/C19H19F3N4O2S/c1-18(2)16(27)26(13-4-6-14(7-5-13)29-19(20,21)22)17(28)25(18)11-12-8-9-24-15(10-12)23-3/h4-10H,11H2,1-3H3,(H,23,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 202 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assay |
Bioorg Med Chem Lett 21: 2224-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340514
(5,5-dimethyl-1-(pyridin-4-ylmethyl)-3-(4-(trifluor...)Show SMILES CC1(C)N(Cc2ccncc2)C(=O)N(C1=O)c1ccc(SC(F)(F)F)cc1 Show InChI InChI=1S/C18H16F3N3O2S/c1-17(2)15(25)24(13-3-5-14(6-4-13)27-18(19,20)21)16(26)23(17)11-12-7-9-22-10-8-12/h3-10H,11H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 264 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assay |
Bioorg Med Chem Lett 21: 2224-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340514
(5,5-dimethyl-1-(pyridin-4-ylmethyl)-3-(4-(trifluor...)Show SMILES CC1(C)N(Cc2ccncc2)C(=O)N(C1=O)c1ccc(SC(F)(F)F)cc1 Show InChI InChI=1S/C18H16F3N3O2S/c1-17(2)15(25)24(13-3-5-14(6-4-13)27-18(19,20)21)16(26)23(17)11-12-7-9-22-10-8-12/h3-10H,11H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 264 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells after 10 mins by time resolved-fluorescent assay |
Bioorg Med Chem Lett 21: 2224-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK |
More data for this
Ligand-Target Pair | |
Insulin receptor
(Homo sapiens (Human)) | BDBM50340484
((5S)-5-methyl-1-(quinolin-4-ylmethyl)-3-{4-[(trifl...)Show SMILES Cc1c(O)n(-c2ccc(cc2)S(=O)(=O)C(F)(F)F)c(=O)n1Cc1ccnc2ccccc12 Show InChI InChI=1S/C21H16F3N3O4S/c1-13-19(28)27(15-6-8-16(9-7-15)32(30,31)21(22,23)24)20(29)26(13)12-14-10-11-25-18-5-3-2-4-17(14)18/h2-11,28H,12H2,1H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description
Inhibition of insulin receptor kinase |
Bioorg Med Chem Lett 21: 2224-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340484
((5S)-5-methyl-1-(quinolin-4-ylmethyl)-3-{4-[(trifl...)Show SMILES Cc1c(O)n(-c2ccc(cc2)S(=O)(=O)C(F)(F)F)c(=O)n1Cc1ccnc2ccccc12 Show InChI InChI=1S/C21H16F3N3O4S/c1-13-19(28)27(15-6-8-16(9-7-15)32(30,31)21(22,23)24)20(29)26(13)12-14-10-11-25-18-5-3-2-4-17(14)18/h2-11,28H,12H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assay |
Bioorg Med Chem Lett 21: 2224-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340516
((S)-5-methyl-1-(quinolin-4-ylmethyl)-3-(4-(trifluo...)Show SMILES Cc1c(O)n(-c2ccc(SC(F)(F)F)cc2)c(=O)n1Cc1ccnc2ccccc12 Show InChI InChI=1S/C21H16F3N3O2S/c1-13-19(28)27(15-6-8-16(9-7-15)30-21(22,23)24)20(29)26(13)12-14-10-11-25-18-5-3-2-4-17(14)18/h2-11,28H,12H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 410 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assay |
Bioorg Med Chem Lett 21: 2224-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340499
(1-((2-(isopropylamino)pyridin-4-yl)methyl)-5,5-dim...)Show SMILES CC(C)Nc1cc(CN2C(=O)N(C(=O)C2(C)C)c2ccc(SC(F)(F)F)cc2)ccn1 Show InChI InChI=1S/C21H23F3N4O2S/c1-13(2)26-17-11-14(9-10-25-17)12-27-19(30)28(18(29)20(27,3)4)15-5-7-16(8-6-15)31-21(22,23)24/h5-11,13H,12H2,1-4H3,(H,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 453 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assay |
Bioorg Med Chem Lett 21: 2224-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340520
(5,5-dimethyl-1-(quinolin-4-ylmethyl)-3-(4-(trifluo...)Show SMILES CC1(C)N(Cc2ccnc3ccccc23)C(=O)N(C1=O)c1ccc(cc1)S(=O)(=O)C(F)(F)F Show InChI InChI=1S/C22H18F3N3O4S/c1-21(2)19(29)28(15-7-9-16(10-8-15)33(31,32)22(23,24)25)20(30)27(21)13-14-11-12-26-18-6-4-3-5-17(14)18/h3-12H,13H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 460 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assay |
Bioorg Med Chem Lett 21: 2224-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340484
((5S)-5-methyl-1-(quinolin-4-ylmethyl)-3-{4-[(trifl...)Show SMILES Cc1c(O)n(-c2ccc(cc2)S(=O)(=O)C(F)(F)F)c(=O)n1Cc1ccnc2ccccc12 Show InChI InChI=1S/C21H16F3N3O4S/c1-13-19(28)27(15-6-8-16(9-7-15)32(30,31)21(22,23)24)20(29)26(13)12-14-10-11-25-18-5-3-2-4-17(14)18/h2-11,28H,12H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assay |
Bioorg Med Chem Lett 21: 2224-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340498
(1-((2-ethylpyridin-4-yl)methyl)-5,5-dimethyl-3-(4-...)Show SMILES CCc1cc(CN2C(=O)N(C(=O)C2(C)C)c2ccc(SC(F)(F)F)cc2)ccn1 Show InChI InChI=1S/C20H20F3N3O2S/c1-4-14-11-13(9-10-24-14)12-25-18(28)26(17(27)19(25,2)3)15-5-7-16(8-6-15)29-20(21,22)23/h5-11H,4,12H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 574 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assay |
Bioorg Med Chem Lett 21: 2224-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340484
((5S)-5-methyl-1-(quinolin-4-ylmethyl)-3-{4-[(trifl...)Show SMILES Cc1c(O)n(-c2ccc(cc2)S(=O)(=O)C(F)(F)F)c(=O)n1Cc1ccnc2ccccc12 Show InChI InChI=1S/C21H16F3N3O4S/c1-13-19(28)27(15-6-8-16(9-7-15)32(30,31)21(22,23)24)20(29)26(13)12-14-10-11-25-18-5-3-2-4-17(14)18/h2-11,28H,12H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description
Inhibition of autophosphosphorylation of human IGF1R expressed in IGF1-stimulated MCF7 cells by ELISA |
Bioorg Med Chem Lett 21: 2224-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK |
More data for this
Ligand-Target Pair | |
Cytochrome P450 2C9
(Homo sapiens (Human)) | BDBM50340484
((5S)-5-methyl-1-(quinolin-4-ylmethyl)-3-{4-[(trifl...)Show SMILES Cc1c(O)n(-c2ccc(cc2)S(=O)(=O)C(F)(F)F)c(=O)n1Cc1ccnc2ccccc12 Show InChI InChI=1S/C21H16F3N3O4S/c1-13-19(28)27(15-6-8-16(9-7-15)32(30,31)21(22,23)24)20(29)26(13)12-14-10-11-25-18-5-3-2-4-17(14)18/h2-11,28H,12H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 700 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description
Inhibition of CYP2C9 |
Bioorg Med Chem Lett 21: 2224-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340497
(4-((5,5-dimethyl-2,4-dioxo-3-(4-(trifluoromethylth...)Show SMILES CNC(=O)c1cc(CN2C(=O)N(C(=O)C2(C)C)c2ccc(SC(F)(F)F)cc2)ccn1 Show InChI InChI=1S/C20H19F3N4O3S/c1-19(2)17(29)27(13-4-6-14(7-5-13)31-20(21,22)23)18(30)26(19)11-12-8-9-25-15(10-12)16(28)24-3/h4-10H,11H2,1-3H3,(H,24,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 703 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assay |
Bioorg Med Chem Lett 21: 2224-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340496
(CHEMBL1762172 | tert-butyl 4-((5,5-dimethyl-2,4-di...)Show SMILES CC(C)(C)OC(=O)Nc1cc(CN2C(=O)N(C(=O)C2(C)C)c2ccc(SC(F)(F)F)cc2)ccn1 Show InChI InChI=1S/C23H25F3N4O4S/c1-21(2,3)34-19(32)28-17-12-14(10-11-27-17)13-29-20(33)30(18(31)22(29,4)5)15-6-8-16(9-7-15)35-23(24,25)26/h6-12H,13H2,1-5H3,(H,27,28,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 784 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assay |
Bioorg Med Chem Lett 21: 2224-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340495
(1-((2-chloropyridin-4-yl)methyl)-5,5-dimethyl-3-(4...)Show SMILES CC1(C)N(Cc2ccnc(Cl)c2)C(=O)N(C1=O)c1ccc(SC(F)(F)F)cc1 Show InChI InChI=1S/C18H15ClF3N3O2S/c1-17(2)15(26)25(12-3-5-13(6-4-12)28-18(20,21)22)16(27)24(17)10-11-7-8-23-14(19)9-11/h3-9H,10H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 995 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assay |
Bioorg Med Chem Lett 21: 2224-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340494
(1-((2-(benzylamino)pyridin-4-yl)methyl)-5,5-dimeth...)Show SMILES CC1(C)N(Cc2ccnc(NCc3ccccc3)c2)C(=O)N(C1=O)c1ccc(SC(F)(F)F)cc1 Show InChI InChI=1S/C25H23F3N4O2S/c1-24(2)22(33)32(19-8-10-20(11-9-19)35-25(26,27)28)23(34)31(24)16-18-12-13-29-21(14-18)30-15-17-6-4-3-5-7-17/h3-14H,15-16H2,1-2H3,(H,29,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.05E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assay |
Bioorg Med Chem Lett 21: 2224-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340493
(5,5-dimethyl-1-((2-(phenylamino)pyridin-4-yl)methy...)Show SMILES CC1(C)N(Cc2ccnc(Nc3ccccc3)c2)C(=O)N(C1=O)c1ccc(SC(F)(F)F)cc1 Show InChI InChI=1S/C24H21F3N4O2S/c1-23(2)21(32)31(18-8-10-19(11-9-18)34-24(25,26)27)22(33)30(23)15-16-12-13-28-20(14-16)29-17-6-4-3-5-7-17/h3-14H,15H2,1-2H3,(H,28,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.06E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assay |
Bioorg Med Chem Lett 21: 2224-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340492
(1-((2-(4-methoxybenzylamino)pyridin-4-yl)methyl)-5...)Show SMILES COc1ccc(CNc2cc(CN3C(=O)N(C(=O)C3(C)C)c3ccc(SC(F)(F)F)cc3)ccn2)cc1 Show InChI InChI=1S/C26H25F3N4O3S/c1-25(2)23(34)33(19-6-10-21(11-7-19)37-26(27,28)29)24(35)32(25)16-18-12-13-30-22(14-18)31-15-17-4-8-20(36-3)9-5-17/h4-14H,15-16H2,1-3H3,(H,30,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.09E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assay |
Bioorg Med Chem Lett 21: 2224-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340491
(1-((2-(cyclohexylamino)pyridin-4-yl)methyl)-5,5-di...)Show SMILES CC1(C)N(Cc2ccnc(NC3CCCCC3)c2)C(=O)N(C1=O)c1ccc(SC(F)(F)F)cc1 Show InChI InChI=1S/C24H27F3N4O2S/c1-23(2)21(32)31(18-8-10-19(11-9-18)34-24(25,26)27)22(33)30(23)15-16-12-13-28-20(14-16)29-17-6-4-3-5-7-17/h8-14,17H,3-7,15H2,1-2H3,(H,28,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.24E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assay |
Bioorg Med Chem Lett 21: 2224-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50059889
((staurosporine)3-methoxy-2-methyl-4-methylamino-(2...)Show SMILES CN[C@@H]1CC2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20?,26-,28+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
KEGG
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.33E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in baculovirus-SF21 cell system preincubated for 5 mins by time... |
Bioorg Med Chem Lett 21: 2224-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50059889
((staurosporine)3-methoxy-2-methyl-4-methylamino-(2...)Show SMILES CN[C@@H]1CC2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20?,26-,28+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
KEGG
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.53E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in baculovirus-SF21 cell system preincubated for 30 mins by tim... |
Bioorg Med Chem Lett 21: 2224-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340504
((S)-5-methyl-1-(pyridin-4-ylmethyl)-3-(4-(trifluor...)Show SMILES Cc1c(O)n(-c2ccc(cc2)S(=O)(=O)C(F)(F)F)c(=O)n1Cc1ccncc1 Show InChI InChI=1S/C17H14F3N3O4S/c1-11-15(24)23(16(25)22(11)10-12-6-8-21-9-7-12)13-2-4-14(5-3-13)28(26,27)17(18,19)20/h2-9,24H,10H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assay |
Bioorg Med Chem Lett 21: 2224-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50059889
((staurosporine)3-methoxy-2-methyl-4-methylamino-(2...)Show SMILES CN[C@@H]1CC2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20?,26-,28+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
KEGG
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.65E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in baculovirus-SF21 cell system preincubated for 60 mins by tim... |
Bioorg Med Chem Lett 21: 2224-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50059889
((staurosporine)3-methoxy-2-methyl-4-methylamino-(2...)Show SMILES CN[C@@H]1CC2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20?,26-,28+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
KEGG
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in baculovirus-SF21 cell system preincubated for 10 mins by tim... |
Bioorg Med Chem Lett 21: 2224-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340490
(1-((2-ethoxypyridin-4-yl)methyl)-5,5-dimethyl-3-(4...)Show SMILES CCOc1cc(CN2C(=O)N(C(=O)C2(C)C)c2ccc(SC(F)(F)F)cc2)ccn1 Show InChI InChI=1S/C20H20F3N3O3S/c1-4-29-16-11-13(9-10-24-16)12-25-18(28)26(17(27)19(25,2)3)14-5-7-15(8-6-14)30-20(21,22)23/h5-11H,4,12H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.85E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assay |
Bioorg Med Chem Lett 21: 2224-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340515
((5S)-5-methyl-1-(quinolin-4-ylmethyl)-3-(4-(triflu...)Show SMILES Cc1c(O)n(-c2ccc(cc2)S(=O)C(F)(F)F)c(=O)n1Cc1ccnc2ccccc12 Show InChI InChI=1S/C21H16F3N3O3S/c1-13-19(28)27(15-6-8-16(9-7-15)31(30)21(22,23)24)20(29)26(13)12-14-10-11-25-18-5-3-2-4-17(14)18/h2-11,28H,12H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.52E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assay |
Bioorg Med Chem Lett 21: 2224-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340489
(1-((2-fluoropyridin-4-yl)methyl)-5,5-dimethyl-3-(4...)Show SMILES CC1(C)N(Cc2ccnc(F)c2)C(=O)N(C1=O)c1ccc(SC(F)(F)F)cc1 Show InChI InChI=1S/C18H15F4N3O2S/c1-17(2)15(26)25(12-3-5-13(6-4-12)28-18(20,21)22)16(27)24(17)10-11-7-8-23-14(19)9-11/h3-9H,10H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assay |
Bioorg Med Chem Lett 21: 2224-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340488
(4-((5,5-dimethyl-2,4-dioxo-3-(4-(trifluoromethylth...)Show SMILES CC1(C)N(Cc2ccnc(c2)C(N)=O)C(=O)N(C1=O)c1ccc(SC(F)(F)F)cc1 Show InChI InChI=1S/C19H17F3N4O3S/c1-18(2)16(28)26(12-3-5-13(6-4-12)30-19(20,21)22)17(29)25(18)10-11-7-8-24-14(9-11)15(23)27/h3-9H,10H2,1-2H3,(H2,23,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2.95E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assay |
Bioorg Med Chem Lett 21: 2224-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340487
(1-((2-(dimethylamino)pyridin-4-yl)methyl)-5,5-dime...)Show SMILES CN(C)c1cc(CN2C(=O)N(C(=O)C2(C)C)c2ccc(SC(F)(F)F)cc2)ccn1 Show InChI InChI=1S/C20H21F3N4O2S/c1-19(2)17(28)27(14-5-7-15(8-6-14)30-20(21,22)23)18(29)26(19)12-13-9-10-24-16(11-13)25(3)4/h5-11H,12H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 4.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assay |
Bioorg Med Chem Lett 21: 2224-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340486
(CHEMBL1762162 | N-(4-((5,5-dimethyl-2,4-dioxo-3-(4...)Show SMILES CC1(C)N(Cc2ccnc(NS(C)(=O)=O)c2)C(=O)N(C1=O)c1ccc(SC(F)(F)F)cc1 Show InChI InChI=1S/C19H19F3N4O4S2/c1-18(2)16(27)26(13-4-6-14(7-5-13)31-19(20,21)22)17(28)25(18)11-12-8-9-23-15(10-12)24-32(3,29)30/h4-10H,11H2,1-3H3,(H,23,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 4.71E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assay |
Bioorg Med Chem Lett 21: 2224-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340518
(1-(quinolin-4-ylmethyl)-3-(4-(trifluoromethylsulfo...)Show SMILES Oc1cn(Cc2ccnc3ccccc23)c(=O)n1-c1ccc(cc1)S(=O)(=O)C(F)(F)F Show InChI InChI=1S/C20H14F3N3O4S/c21-20(22,23)31(29,30)15-7-5-14(6-8-15)26-18(27)12-25(19(26)28)11-13-9-10-24-17-4-2-1-3-16(13)17/h1-10,12,27H,11H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assay |
Bioorg Med Chem Lett 21: 2224-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340522
(5,5-dimethyl-1-((2-morpholinopyridin-4-yl)methyl)-...)Show SMILES CC1(C)N(Cc2ccnc(c2)N2CCOCC2)C(=O)N(C1=O)c1ccc(SC(F)(F)F)cc1 Show InChI InChI=1S/C22H23F3N4O3S/c1-21(2)19(30)29(16-3-5-17(6-4-16)33-22(23,24)25)20(31)28(21)14-15-7-8-26-18(13-15)27-9-11-32-12-10-27/h3-8,13H,9-12,14H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assay |
Bioorg Med Chem Lett 21: 2224-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340485
(4-((5,5-dimethyl-2,4-dioxo-3-(4-(trifluoromethylth...)Show SMILES CC1(C)N(Cc2ccnc(c2)C(O)=O)C(=O)N(C1=O)c1ccc(SC(F)(F)F)cc1 Show InChI InChI=1S/C19H16F3N3O4S/c1-18(2)16(28)25(12-3-5-13(6-4-12)30-19(20,21)22)17(29)24(18)10-11-7-8-23-14(9-11)15(26)27/h3-9H,10H2,1-2H3,(H,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assay |
Bioorg Med Chem Lett 21: 2224-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340523
(5,5-dimethyl-1-((2-(4-methylpiperazin-1-yl)pyridin...)Show SMILES CN1CCN(CC1)c1cc(CN2C(=O)N(C(=O)C2(C)C)c2ccc(SC(F)(F)F)cc2)ccn1 Show InChI InChI=1S/C23H26F3N5O2S/c1-22(2)20(32)31(17-4-6-18(7-5-17)34-23(24,25)26)21(33)30(22)15-16-8-9-27-19(14-16)29-12-10-28(3)11-13-29/h4-9,14H,10-13,15H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assay |
Bioorg Med Chem Lett 21: 2224-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340525
(4-((5,5-dimethyl-2,4-dioxo-3-(4-(trifluoromethylth...)Show SMILES CC1(C)N(Cc2ccnc(c2)C#N)C(=O)N(C1=O)c1ccc(SC(F)(F)F)cc1 Show InChI InChI=1S/C19H15F3N4O2S/c1-18(2)16(27)26(14-3-5-15(6-4-14)29-19(20,21)22)17(28)25(18)11-12-7-8-24-13(9-12)10-23/h3-9H,11H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assay |
Bioorg Med Chem Lett 21: 2224-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340524
(5,5-dimethyl-1-((2-(piperazin-1-yl)pyridin-4-yl)me...)Show SMILES CC1(C)N(Cc2ccnc(c2)N2CCNCC2)C(=O)N(C1=O)c1ccc(SC(F)(F)F)cc1 Show InChI InChI=1S/C22H24F3N5O2S/c1-21(2)19(31)30(16-3-5-17(6-4-16)33-22(23,24)25)20(32)29(21)14-15-7-8-27-18(13-15)28-11-9-26-10-12-28/h3-8,13,26H,9-12,14H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assay |
Bioorg Med Chem Lett 21: 2224-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340521
(5,5-dimethyl-1-((2-(piperidin-1-yl)pyridin-4-yl)me...)Show SMILES CC1(C)N(Cc2ccnc(c2)N2CCCCC2)C(=O)N(C1=O)c1ccc(SC(F)(F)F)cc1 Show InChI InChI=1S/C23H25F3N4O2S/c1-22(2)20(31)30(17-6-8-18(9-7-17)33-23(24,25)26)21(32)29(22)15-16-10-11-27-19(14-16)28-12-4-3-5-13-28/h6-11,14H,3-5,12-13,15H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assay |
Bioorg Med Chem Lett 21: 2224-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK |
More data for this
Ligand-Target Pair | |
Cytochrome P450 2D6
(Homo sapiens (Human)) | BDBM50340484
((5S)-5-methyl-1-(quinolin-4-ylmethyl)-3-{4-[(trifl...)Show SMILES Cc1c(O)n(-c2ccc(cc2)S(=O)(=O)C(F)(F)F)c(=O)n1Cc1ccnc2ccccc12 Show InChI InChI=1S/C21H16F3N3O4S/c1-13-19(28)27(15-6-8-16(9-7-15)32(30,31)21(22,23)24)20(29)26(13)12-14-10-11-25-18-5-3-2-4-17(14)18/h2-11,28H,12H2,1H3 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description
Inhibition of CYP2D6 |
Bioorg Med Chem Lett 21: 2224-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK |
More data for this
Ligand-Target Pair | |
Cytochrome P450 2C19
(Homo sapiens (Human)) | BDBM50340484
((5S)-5-methyl-1-(quinolin-4-ylmethyl)-3-{4-[(trifl...)Show SMILES Cc1c(O)n(-c2ccc(cc2)S(=O)(=O)C(F)(F)F)c(=O)n1Cc1ccnc2ccccc12 Show InChI InChI=1S/C21H16F3N3O4S/c1-13-19(28)27(15-6-8-16(9-7-15)32(30,31)21(22,23)24)20(29)26(13)12-14-10-11-25-18-5-3-2-4-17(14)18/h2-11,28H,12H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description
Inhibition of CYP2C19 |
Bioorg Med Chem Lett 21: 2224-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK |
More data for this
Ligand-Target Pair | |
Cytochrome P450 1A2
(Homo sapiens (Human)) | BDBM50340484
((5S)-5-methyl-1-(quinolin-4-ylmethyl)-3-{4-[(trifl...)Show SMILES Cc1c(O)n(-c2ccc(cc2)S(=O)(=O)C(F)(F)F)c(=O)n1Cc1ccnc2ccccc12 Show InChI InChI=1S/C21H16F3N3O4S/c1-13-19(28)27(15-6-8-16(9-7-15)32(30,31)21(22,23)24)20(29)26(13)12-14-10-11-25-18-5-3-2-4-17(14)18/h2-11,28H,12H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description
Inhibition of CYP1A2 |
Bioorg Med Chem Lett 21: 2224-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK |
More data for this
Ligand-Target Pair | |
Cytochrome P450 3A4
(Homo sapiens (Human)) | BDBM50340484
((5S)-5-methyl-1-(quinolin-4-ylmethyl)-3-{4-[(trifl...)Show SMILES Cc1c(O)n(-c2ccc(cc2)S(=O)(=O)C(F)(F)F)c(=O)n1Cc1ccnc2ccccc12 Show InChI InChI=1S/C21H16F3N3O4S/c1-13-19(28)27(15-6-8-16(9-7-15)32(30,31)21(22,23)24)20(29)26(13)12-14-10-11-25-18-5-3-2-4-17(14)18/h2-11,28H,12H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description
Inhibition of CYP3A4 |
Bioorg Med Chem Lett 21: 2224-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340505
((S)-5-methyl-1-(pyridin-3-ylmethyl)-3-(4-(trifluor...)Show SMILES Cc1c(O)n(-c2ccc(cc2)S(=O)(=O)C(F)(F)F)c(=O)n1Cc1cccnc1 Show InChI InChI=1S/C17H14F3N3O4S/c1-11-15(24)23(16(25)22(11)10-12-3-2-8-21-9-12)13-4-6-14(7-5-13)28(26,27)17(18,19)20/h2-9,24H,10H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.97E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assay |
Bioorg Med Chem Lett 21: 2224-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340508
((S)-1-((1H-imidazol-4-yl)methyl)-5-methyl-3-(4-(tr...)Show SMILES Cc1c(O)n(-c2ccc(cc2)S(=O)(=O)C(F)(F)F)c(=O)n1Cc1cnc[nH]1 Show InChI InChI=1S/C15H13F3N4O4S/c1-9-13(23)22(14(24)21(9)7-10-6-19-8-20-10)11-2-4-12(5-3-11)27(25,26)15(16,17)18/h2-6,8,23H,7H2,1H3,(H,19,20) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assay |
Bioorg Med Chem Lett 21: 2224-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340507
((S)-1-(isoquinolin-4-ylmethyl)-5-methyl-3-(4-(trif...)Show SMILES Cc1c(O)n(-c2ccc(cc2)S(=O)(=O)C(F)(F)F)c(=O)n1Cc1cncc2ccccc12 Show InChI InChI=1S/C21H16F3N3O4S/c1-13-19(28)27(16-6-8-17(9-7-16)32(30,31)21(22,23)24)20(29)26(13)12-15-11-25-10-14-4-2-3-5-18(14)15/h2-11,28H,12H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assay |
Bioorg Med Chem Lett 21: 2224-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340512
((S)-4-((5-methyl-2,4-dioxo-3-(4-(trifluoromethylsu...)Show SMILES Cc1c(O)n(-c2ccc(cc2)S(=O)(=O)C(F)(F)F)c(=O)n1Cc1cc[n+]([O-])c2ccccc12 Show InChI InChI=1S/C21H16F3N3O5S/c1-13-19(28)27(15-6-8-16(9-7-15)33(31,32)21(22,23)24)20(29)25(13)12-14-10-11-26(30)18-5-3-2-4-17(14)18/h2-11,28H,12H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assay |
Bioorg Med Chem Lett 21: 2224-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340510
((S)-1-benzyl-5-methyl-3-(4-(trifluoromethylsulfony...)Show SMILES Cc1c(O)n(-c2ccc(cc2)S(=O)(=O)C(F)(F)F)c(=O)n1Cc1ccccc1 Show InChI InChI=1S/C18H15F3N2O4S/c1-12-16(24)23(17(25)22(12)11-13-5-3-2-4-6-13)14-7-9-15(10-8-14)28(26,27)18(19,20)21/h2-10,24H,11H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assay |
Bioorg Med Chem Lett 21: 2224-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340509
((S)-5-methyl-1-(piperidin-4-ylmethyl)-3-(4-(triflu...)Show SMILES Cc1c(O)n(-c2ccc(cc2)S(=O)(=O)C(F)(F)F)c(=O)n1CC1CCNCC1 Show InChI InChI=1S/C17H20F3N3O4S/c1-11-15(24)23(16(25)22(11)10-12-6-8-21-9-7-12)13-2-4-14(5-3-13)28(26,27)17(18,19)20/h2-5,12,21,24H,6-10H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assay |
Bioorg Med Chem Lett 21: 2224-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340517
((S)-5-methyl-3-(4-(methylsulfonyl)phenyl)-1-(quino...)Show SMILES Cc1c(O)n(-c2ccc(cc2)S(C)(=O)=O)c(=O)n1Cc1ccnc2ccccc12 Show InChI InChI=1S/C21H19N3O4S/c1-14-20(25)24(16-7-9-17(10-8-16)29(2,27)28)21(26)23(14)13-15-11-12-22-19-6-4-3-5-18(15)19/h3-12,25H,13H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assay |
Bioorg Med Chem Lett 21: 2224-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340511
((S)-4-((5-methyl-2,4-dioxo-3-(4-(trifluoromethylsu...)Show SMILES Cc1c(O)n(-c2ccc(cc2)S(=O)(=O)C(F)(F)F)c(=O)n1Cc1cc[n+]([O-])cc1 Show InChI InChI=1S/C17H14F3N3O5S/c1-11-15(24)23(16(25)22(11)10-12-6-8-21(26)9-7-12)13-2-4-14(5-3-13)29(27,28)17(18,19)20/h2-9,24H,10H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assay |
Bioorg Med Chem Lett 21: 2224-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50340506
((S)-5-methyl-1-(pyridin-2-ylmethyl)-3-(4-(trifluor...)Show SMILES Cc1c(O)n(-c2ccc(cc2)S(=O)(=O)C(F)(F)F)c(=O)n1Cc1ccccn1 Show InChI InChI=1S/C17H14F3N3O4S/c1-11-15(24)23(16(25)22(11)10-12-4-2-3-9-21-12)13-5-7-14(8-6-13)28(26,27)17(18,19)20/h2-9,24H,10H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-aventis
Curated by ChEMBL
| Assay Description
Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assay |
Bioorg Med Chem Lett 21: 2224-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.003
BindingDB Entry DOI: 10.7270/Q2CC11PK |
More data for this
Ligand-Target Pair | |
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