Found 60 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
(Homo sapiens (Human)) | BDBM50344013
(CHEMBL1780094 | trans-(3R,5S)-N-((6-aminopyridin-2...)Show SMILES Cc1oc(nc1CN1C[C@@H](C[C@H](C1)c1ccccc1)C(=O)NCc1cccc(N)n1)-c1ccccc1 |r| Show InChI InChI=1S/C29H31N5O2/c1-20-26(33-29(36-20)22-11-6-3-7-12-22)19-34-17-23(21-9-4-2-5-10-21)15-24(18-34)28(35)31-16-25-13-8-14-27(30)32-25/h2-14,23-24H,15-19H2,1H3,(H2,30,32)(H,31,35)/t23-,24-/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.120 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of PDE8B |
Bioorg Med Chem Lett 21: 3095-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.022
BindingDB Entry DOI: 10.7270/Q20002F8 |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
(Homo sapiens (Human)) | BDBM50344014
(CHEMBL1779987 | trans-(3R,5S)-1-((5-methyl-2-pheny...)Show SMILES Cc1oc(nc1CN1C[C@@H](C[C@H](C1)c1ccccc1)C(=O)NCc1cccc(C)n1)-c1ccccc1 |r| Show InChI InChI=1S/C30H32N4O2/c1-21-10-9-15-27(32-21)17-31-29(35)26-16-25(23-11-5-3-6-12-23)18-34(19-26)20-28-22(2)36-30(33-28)24-13-7-4-8-14-24/h3-15,25-26H,16-20H2,1-2H3,(H,31,35)/t25-,26-/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of PDE8B |
Bioorg Med Chem Lett 21: 3095-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.022
BindingDB Entry DOI: 10.7270/Q20002F8 |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
(Homo sapiens (Human)) | BDBM50344015
(CHEMBL1780096 | trans-(3S,5S)-5-ethyl-1-((5-methyl...)Show SMILES CC[C@H]1C[C@@H](CN(Cc2nc(oc2C)-c2ccccc2)C1)C(=O)NCc1cccc(C)n1 |r| Show InChI InChI=1S/C26H32N4O2/c1-4-20-13-22(25(31)27-14-23-12-8-9-18(2)28-23)16-30(15-20)17-24-19(3)32-26(29-24)21-10-6-5-7-11-21/h5-12,20,22H,4,13-17H2,1-3H3,(H,27,31)/t20-,22-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.955 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of PDE8B |
Bioorg Med Chem Lett 21: 3095-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.022
BindingDB Entry DOI: 10.7270/Q20002F8 |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
(Homo sapiens (Human)) | BDBM50344016
(2-((5-methyl-2-phenyloxazol-4-yl)methyl)-N-((6-met...)Show SMILES Cc1oc(nc1CN1CC(C(=O)NCc2cccc(C)n2)c2ccccc2C1)-c1ccccc1 Show InChI InChI=1S/C28H28N4O2/c1-19-9-8-13-23(30-19)15-29-27(33)25-17-32(16-22-12-6-7-14-24(22)25)18-26-20(2)34-28(31-26)21-10-4-3-5-11-21/h3-14,25H,15-18H2,1-2H3,(H,29,33) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of PDE8A |
Bioorg Med Chem Lett 21: 3095-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.022
BindingDB Entry DOI: 10.7270/Q20002F8 |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
(Homo sapiens (Human)) | BDBM50344018
(CHEMBL1779984 | trans-(3R,5R)-5-ethyl-1-((5-methyl...)Show SMILES CC[C@@H]1C[C@H](CN(Cc2nc(oc2C)-c2ccccc2)C1)C(=O)NCc1cccc(C)n1 |r| Show InChI InChI=1S/C26H32N4O2/c1-4-20-13-22(25(31)27-14-23-12-8-9-18(2)28-23)16-30(15-20)17-24-19(3)32-26(29-24)21-10-6-5-7-11-21/h5-12,20,22H,4,13-17H2,1-3H3,(H,27,31)/t20-,22-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of PDE8A |
Bioorg Med Chem Lett 21: 3095-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.022
BindingDB Entry DOI: 10.7270/Q20002F8 |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
(Homo sapiens (Human)) | BDBM50344017
(1-((5-methyl-2-phenyloxazol-4-yl)methyl)-N-((6-met...)Show SMILES Cc1oc(nc1CN1CCCC(C1)C(=O)NCc1cccc(C)n1)-c1ccccc1 Show InChI InChI=1S/C24H28N4O2/c1-17-8-6-12-21(26-17)14-25-23(29)20-11-7-13-28(15-20)16-22-18(2)30-24(27-22)19-9-4-3-5-10-19/h3-6,8-10,12,20H,7,11,13-16H2,1-2H3,(H,25,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of PDE8A |
Bioorg Med Chem Lett 21: 3095-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.022
BindingDB Entry DOI: 10.7270/Q20002F8 |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
(Homo sapiens (Human)) | BDBM50344019
(CHEMBL1780085 | trans-(3R,5R)-5-(methoxymethyl)-1-...)Show SMILES COC[C@@H]1C[C@H](CN(Cc2nc(oc2C)-c2ccccc2)C1)C(=O)NCC1CCOCC1 |r| Show InChI InChI=1S/C25H35N3O4/c1-18-23(27-25(32-18)21-6-4-3-5-7-21)16-28-14-20(17-30-2)12-22(15-28)24(29)26-13-19-8-10-31-11-9-19/h3-7,19-20,22H,8-17H2,1-2H3,(H,26,29)/t20-,22-/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.96 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of PDE8B |
Bioorg Med Chem Lett 21: 3095-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.022
BindingDB Entry DOI: 10.7270/Q20002F8 |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
(Homo sapiens (Human)) | BDBM50344020
(CHEMBL1780116 | trans-(3R,5R)-5-ethyl-1-((5-methyl...)Show SMILES CC[C@@H]1C[C@H](CN(Cc2nc(oc2C)-c2ccccc2)C1)C(=O)NC[C@H]1CCCO1 |r| Show InChI InChI=1S/C24H33N3O3/c1-3-18-12-20(23(28)25-13-21-10-7-11-29-21)15-27(14-18)16-22-17(2)30-24(26-22)19-8-5-4-6-9-19/h4-6,8-9,18,20-21H,3,7,10-16H2,1-2H3,(H,25,28)/t18-,20-,21-/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.91 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of PDE8B |
Bioorg Med Chem Lett 21: 3095-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.022
BindingDB Entry DOI: 10.7270/Q20002F8 |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
(Homo sapiens (Human)) | BDBM50344021
(CHEMBL1779988 | trans-(3R,5R)-5-(methoxymethyl)-1-...)Show SMILES COC[C@@H]1C[C@H](CN(Cc2nc(oc2C)-c2ccccc2)C1)C(=O)NCc1cccc(C)n1 |r| Show InChI InChI=1S/C26H32N4O3/c1-18-8-7-11-23(28-18)13-27-25(31)22-12-20(17-32-3)14-30(15-22)16-24-19(2)33-26(29-24)21-9-5-4-6-10-21/h4-11,20,22H,12-17H2,1-3H3,(H,27,31)/t20-,22-/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of PDE8B |
Bioorg Med Chem Lett 21: 3095-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.022
BindingDB Entry DOI: 10.7270/Q20002F8 |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
(Homo sapiens (Human)) | BDBM50344022
(CHEMBL1780100 | trans-(3S,5S)-5-(3-methyl-1,2,4-ox...)Show SMILES Cc1noc(n1)[C@H]1C[C@@H](CN(Cc2nc(oc2C)-c2ccccc2)C1)C(=O)NCc1cccc(C)n1 |r| Show InChI InChI=1S/C27H30N6O3/c1-17-8-7-11-23(29-17)13-28-25(34)21-12-22(27-30-19(3)32-36-27)15-33(14-21)16-24-18(2)35-26(31-24)20-9-5-4-6-10-20/h4-11,21-22H,12-16H2,1-3H3,(H,28,34)/t21-,22-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.86 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of PDE8B |
Bioorg Med Chem Lett 21: 3095-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.022
BindingDB Entry DOI: 10.7270/Q20002F8 |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
(Homo sapiens (Human)) | BDBM50344023
(CHEMBL1780089 | trans-(3R,5R)-5-(3-methyl-1,2,4-ox...)Show SMILES Cc1noc(n1)[C@@H]1C[C@H](CN(Cc2nc(oc2C)-c2ccccc2)C1)C(=O)NCc1cccc(C)n1 |r| Show InChI InChI=1S/C27H30N6O3/c1-17-8-7-11-23(29-17)13-28-25(34)21-12-22(27-30-19(3)32-36-27)15-33(14-21)16-24-18(2)35-26(31-24)20-9-5-4-6-10-20/h4-11,21-22H,12-16H2,1-3H3,(H,28,34)/t21-,22-/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of PDE8B |
Bioorg Med Chem Lett 21: 3095-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.022
BindingDB Entry DOI: 10.7270/Q20002F8 |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
(Homo sapiens (Human)) | BDBM50344024
(CHEMBL1780097 | trans-(3S,5S)-5-(methoxymethyl)-1-...)Show SMILES COC[C@H]1C[C@@H](CN(Cc2nc(oc2C)-c2ccccc2)C1)C(=O)NCc1cccc(C)n1 |r| Show InChI InChI=1S/C26H32N4O3/c1-18-8-7-11-23(28-18)13-27-25(31)22-12-20(17-32-3)14-30(15-22)16-24-19(2)33-26(29-24)21-9-5-4-6-10-21/h4-11,20,22H,12-17H2,1-3H3,(H,27,31)/t20-,22-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of PDE8B |
Bioorg Med Chem Lett 21: 3095-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.022
BindingDB Entry DOI: 10.7270/Q20002F8 |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
(Homo sapiens (Human)) | BDBM50344025
(CHEMBL1780105 | trans-(3R,5R)-5-(methoxymethyl)-1-...)Show SMILES COC[C@@H]1C[C@H](CN(Cc2nc(oc2C)-c2ccccc2)C1)C(=O)NC[C@H]1CCCO1 |r| Show InChI InChI=1S/C24H33N3O4/c1-17-22(26-24(31-17)19-7-4-3-5-8-19)15-27-13-18(16-29-2)11-20(14-27)23(28)25-12-21-9-6-10-30-21/h3-5,7-8,18,20-21H,6,9-16H2,1-2H3,(H,25,28)/t18-,20-,21-/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.36 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of PDE8B |
Bioorg Med Chem Lett 21: 3095-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.022
BindingDB Entry DOI: 10.7270/Q20002F8 |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
(Homo sapiens (Human)) | BDBM50344026
(CHEMBL1780111 | trans-(3R,5R)-N-((6-aminopyridin-2...)Show SMILES CC[C@@H]1C[C@H](CN(Cc2nc(oc2C)-c2ccccc2)C1)C(=O)NCc1cccc(N)n1 |r| Show InChI InChI=1S/C25H31N5O2/c1-3-18-12-20(24(31)27-13-21-10-7-11-23(26)28-21)15-30(14-18)16-22-17(2)32-25(29-22)19-8-5-4-6-9-19/h4-11,18,20H,3,12-16H2,1-2H3,(H2,26,28)(H,27,31)/t18-,20-/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.42 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of PDE8B |
Bioorg Med Chem Lett 21: 3095-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.022
BindingDB Entry DOI: 10.7270/Q20002F8 |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
(Homo sapiens (Human)) | BDBM50344016
(2-((5-methyl-2-phenyloxazol-4-yl)methyl)-N-((6-met...)Show SMILES Cc1oc(nc1CN1CC(C(=O)NCc2cccc(C)n2)c2ccccc2C1)-c1ccccc1 Show InChI InChI=1S/C28H28N4O2/c1-19-9-8-13-23(30-19)15-29-27(33)25-17-32(16-22-12-6-7-14-24(22)25)18-26-20(2)34-28(31-26)21-10-4-3-5-11-21/h3-14,25H,15-18H2,1-2H3,(H,29,33) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of PDE8B |
Bioorg Med Chem Lett 21: 3095-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.022
BindingDB Entry DOI: 10.7270/Q20002F8 |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
(Homo sapiens (Human)) | BDBM50344018
(CHEMBL1779984 | trans-(3R,5R)-5-ethyl-1-((5-methyl...)Show SMILES CC[C@@H]1C[C@H](CN(Cc2nc(oc2C)-c2ccccc2)C1)C(=O)NCc1cccc(C)n1 |r| Show InChI InChI=1S/C26H32N4O2/c1-4-20-13-22(25(31)27-14-23-12-8-9-18(2)28-23)16-30(15-20)17-24-19(3)32-26(29-24)21-10-6-5-7-11-21/h5-12,20,22H,4,13-17H2,1-3H3,(H,27,31)/t20-,22-/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of PDE8B |
Bioorg Med Chem Lett 21: 3095-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.022
BindingDB Entry DOI: 10.7270/Q20002F8 |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
(Homo sapiens (Human)) | BDBM50344027
(CHEMBL1779985 | trans-(3R,5R)-1-((5-methyl-2-pheny...)Show SMILES CCC[C@@H]1C[C@H](CN(Cc2nc(oc2C)-c2ccccc2)C1)C(=O)NCc1cccc(C)n1 |r| Show InChI InChI=1S/C27H34N4O2/c1-4-9-21-14-23(26(32)28-15-24-13-8-10-19(2)29-24)17-31(16-21)18-25-20(3)33-27(30-25)22-11-6-5-7-12-22/h5-8,10-13,21,23H,4,9,14-18H2,1-3H3,(H,28,32)/t21-,23-/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of PDE8B |
Bioorg Med Chem Lett 21: 3095-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.022
BindingDB Entry DOI: 10.7270/Q20002F8 |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
(Homo sapiens (Human)) | BDBM50344028
(CHEMBL1779990 | trans-(3R,5R)-1-((5-methyl-2-pheny...)Show SMILES CC(=O)O[C@@H]1C[C@H](CN(Cc2nc(oc2C)-c2ccccc2)C1)C(=O)NCc1cccc(C)n1 |r| Show InChI InChI=1S/C26H30N4O4/c1-17-8-7-11-22(28-17)13-27-25(32)21-12-23(34-19(3)31)15-30(14-21)16-24-18(2)33-26(29-24)20-9-5-4-6-10-20/h4-11,21,23H,12-16H2,1-3H3,(H,27,32)/t21-,23-/m1/s1 | Reactome pathway
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| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of PDE8B |
Bioorg Med Chem Lett 21: 3095-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.022
BindingDB Entry DOI: 10.7270/Q20002F8 |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
(Homo sapiens (Human)) | BDBM50344029
(CHEMBL1780084 | trans-(3R,5R)-5-ethyl-1-((5-methyl...)Show SMILES CC[C@@H]1C[C@H](CN(Cc2nc(oc2C)-c2ccccc2)C1)C(=O)NCC1CCOCC1 |r| Show InChI InChI=1S/C25H35N3O3/c1-3-19-13-22(24(29)26-14-20-9-11-30-12-10-20)16-28(15-19)17-23-18(2)31-25(27-23)21-7-5-4-6-8-21/h4-8,19-20,22H,3,9-17H2,1-2H3,(H,26,29)/t19-,22-/m1/s1 | Reactome pathway
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| n/a | n/a | 7.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of PDE8B |
Bioorg Med Chem Lett 21: 3095-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.022
BindingDB Entry DOI: 10.7270/Q20002F8 |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
(Homo sapiens (Human)) | BDBM50344030
(CHEMBL1780087 | trans-(3R,5R)-5-(methoxymethyl)-1-...)Show SMILES COC[C@@H]1C[C@H](CN(Cc2[nH]c(nc2C)-c2ccncn2)C1)C(=O)NCC1CCOCC1 |r| Show InChI InChI=1S/C23H34N6O3/c1-16-21(28-22(27-16)20-3-6-24-15-26-20)13-29-11-18(14-31-2)9-19(12-29)23(30)25-10-17-4-7-32-8-5-17/h3,6,15,17-19H,4-5,7-14H2,1-2H3,(H,25,30)(H,27,28)/t18-,19-/m1/s1 | Reactome pathway
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| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of PDE8B |
Bioorg Med Chem Lett 21: 3095-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.022
BindingDB Entry DOI: 10.7270/Q20002F8 |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
(Homo sapiens (Human)) | BDBM50344031
(CHEMBL1779986 | trans-(3R,5R)-5-butyl-1-((5-methyl...)Show SMILES CCCC[C@@H]1C[C@H](CN(Cc2nc(oc2C)-c2ccccc2)C1)C(=O)NCc1cccc(C)n1 |r| Show InChI InChI=1S/C28H36N4O2/c1-4-5-11-22-15-24(27(33)29-16-25-14-9-10-20(2)30-25)18-32(17-22)19-26-21(3)34-28(31-26)23-12-7-6-8-13-23/h6-10,12-14,22,24H,4-5,11,15-19H2,1-3H3,(H,29,33)/t22-,24-/m1/s1 | Reactome pathway
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| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of PDE8B |
Bioorg Med Chem Lett 21: 3095-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.022
BindingDB Entry DOI: 10.7270/Q20002F8 |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
(Homo sapiens (Human)) | BDBM50344032
(CHEMBL1780086 | trans-(3R,5R)-N-((6-aminopyridin-2...)Show SMILES CC[C@@H]1C[C@H](CN(Cc2nc(oc2C)N2CCOCC2)C1)C(=O)NCc1cccc(N)n1 |r| Show InChI InChI=1S/C23H34N6O3/c1-3-17-11-18(22(30)25-12-19-5-4-6-21(24)26-19)14-28(13-17)15-20-16(2)32-23(27-20)29-7-9-31-10-8-29/h4-6,17-18H,3,7-15H2,1-2H3,(H2,24,26)(H,25,30)/t17-,18-/m1/s1 | Reactome pathway
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| n/a | n/a | 16.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of PDE8B |
Bioorg Med Chem Lett 21: 3095-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.022
BindingDB Entry DOI: 10.7270/Q20002F8 |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
(Homo sapiens (Human)) | BDBM50344033
(CHEMBL1780102 | trans-(3R,5R)-5-ethyl-1-((5-methyl...)Show SMILES CC[C@@H]1C[C@H](CN(Cc2nc(oc2C)-c2ccccc2)C1)C(=O)NC[C@@H]1CCCO1 |r| Show InChI InChI=1S/C24H33N3O3/c1-3-18-12-20(23(28)25-13-21-10-7-11-29-21)15-27(14-18)16-22-17(2)30-24(26-22)19-8-5-4-6-9-19/h4-6,8-9,18,20-21H,3,7,10-16H2,1-2H3,(H,25,28)/t18-,20-,21+/m1/s1 | Reactome pathway
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| n/a | n/a | 19.6 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of PDE8B |
Bioorg Med Chem Lett 21: 3095-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.022
BindingDB Entry DOI: 10.7270/Q20002F8 |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
(Homo sapiens (Human)) | BDBM50344034
(CHEMBL1780090 | trans-(3R,5R)-5-ethyl-1-((5-methyl...)Show SMILES CC[C@@H]1C[C@H](CN(Cc2[nH]c(nc2C)-c2ccncn2)C1)C(=O)NC[C@H]1CCCO1 |r| Show InChI InChI=1S/C22H32N6O2/c1-3-16-9-17(22(29)24-10-18-5-4-8-30-18)12-28(11-16)13-20-15(2)26-21(27-20)19-6-7-23-14-25-19/h6-7,14,16-18H,3-5,8-13H2,1-2H3,(H,24,29)(H,26,27)/t16-,17-,18-/m1/s1 | Reactome pathway
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| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of PDE8B |
Bioorg Med Chem Lett 21: 3095-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.022
BindingDB Entry DOI: 10.7270/Q20002F8 |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
(Homo sapiens (Human)) | BDBM50344035
(CHEMBL1780104 | trans-(3R,5R)-5-ethyl-1-((5-methyl...)Show SMILES CC[C@@H]1C[C@H](CN(Cc2[nH]c(nc2C)-c2ccncn2)C1)C(=O)NC[C@@H]1CCCO1 |r| Show InChI InChI=1S/C22H32N6O2/c1-3-16-9-17(22(29)24-10-18-5-4-8-30-18)12-28(11-16)13-20-15(2)26-21(27-20)19-6-7-23-14-25-19/h6-7,14,16-18H,3-5,8-13H2,1-2H3,(H,24,29)(H,26,27)/t16-,17-,18+/m1/s1 | Reactome pathway
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PubMed
| n/a | n/a | 26.2 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of PDE8B |
Bioorg Med Chem Lett 21: 3095-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.022
BindingDB Entry DOI: 10.7270/Q20002F8 |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
(Homo sapiens (Human)) | BDBM50344036
(CHEMBL1780103 | trans-(3R,5R)-5-(3-methyl-1,2,4-ox...)Show SMILES Cc1noc(n1)[C@@H]1C[C@H](CN(Cc2nc(oc2C)-c2ccccc2)C1)C(=O)NC[C@@H]1CCCO1 |r| Show InChI InChI=1S/C25H31N5O4/c1-16-22(28-24(33-16)18-7-4-3-5-8-18)15-30-13-19(23(31)26-12-21-9-6-10-32-21)11-20(14-30)25-27-17(2)29-34-25/h3-5,7-8,19-21H,6,9-15H2,1-2H3,(H,26,31)/t19-,20-,21+/m1/s1 | Reactome pathway
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| n/a | n/a | 35.2 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of PDE8B |
Bioorg Med Chem Lett 21: 3095-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.022
BindingDB Entry DOI: 10.7270/Q20002F8 |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
(Homo sapiens (Human)) | BDBM50344037
(CHEMBL1779983 | trans-(3R,5R)-5-methyl-1-((5-methy...)Show SMILES C[C@@H]1C[C@H](CN(Cc2nc(oc2C)-c2ccccc2)C1)C(=O)NCc1cccc(C)n1 |r| Show InChI InChI=1S/C25H30N4O2/c1-17-12-21(24(30)26-13-22-11-7-8-18(2)27-22)15-29(14-17)16-23-19(3)31-25(28-23)20-9-5-4-6-10-20/h4-11,17,21H,12-16H2,1-3H3,(H,26,30)/t17-,21-/m1/s1 | Reactome pathway
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| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of PDE8B |
Bioorg Med Chem Lett 21: 3095-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.022
BindingDB Entry DOI: 10.7270/Q20002F8 |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
(Homo sapiens (Human)) | BDBM50344000
(5-(methoxymethyl)-1-((5-methyl-2-morpholinooxazol-...)Show SMILES COCC1CC(CN(Cc2nc(oc2C)N2CCOCC2)C1)C(=O)NC[C@H]1CCCO1 |r| Show InChI InChI=1S/C22H36N4O5/c1-16-20(24-22(31-16)26-5-8-29-9-6-26)14-25-12-17(15-28-2)10-18(13-25)21(27)23-11-19-4-3-7-30-19/h17-19H,3-15H2,1-2H3,(H,23,27)/t17?,18?,19-/m1/s1 | Reactome pathway
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| n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of PDE8B |
Bioorg Med Chem Lett 21: 3095-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.022
BindingDB Entry DOI: 10.7270/Q20002F8 |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
(Homo sapiens (Human)) | BDBM50344038
(CHEMBL1780118 | trans-(3R,5R)-5-(methoxymethyl)-1-...)Show SMILES COC[C@@H]1C[C@H](CN(Cc2nc(oc2C)N2CCOCC2)C1)C(=O)NCC1CCOCC1 |r| Show InChI InChI=1S/C23H38N4O5/c1-17-21(25-23(32-17)27-5-9-31-10-6-27)15-26-13-19(16-29-2)11-20(14-26)22(28)24-12-18-3-7-30-8-4-18/h18-20H,3-16H2,1-2H3,(H,24,28)/t19-,20-/m1/s1 | Reactome pathway
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| n/a | n/a | 44.1 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of PDE8B |
Bioorg Med Chem Lett 21: 3095-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.022
BindingDB Entry DOI: 10.7270/Q20002F8 |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
(Homo sapiens (Human)) | BDBM50344039
((R)-N-((6-aminopyridin-2-yl)methyl)-1-((5-methyl-2...)Show SMILES Cc1oc(nc1CN1CCC[C@H](C1)C(=O)NCc1cccc(N)n1)-c1ccccc1 |r| Show InChI InChI=1S/C23H27N5O2/c1-16-20(27-23(30-16)17-7-3-2-4-8-17)15-28-12-6-9-18(14-28)22(29)25-13-19-10-5-11-21(24)26-19/h2-5,7-8,10-11,18H,6,9,12-15H2,1H3,(H2,24,26)(H,25,29)/t18-/m1/s1 | Reactome pathway
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| n/a | n/a | 58 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of PDE8B |
Bioorg Med Chem Lett 21: 3095-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.022
BindingDB Entry DOI: 10.7270/Q20002F8 |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
(Homo sapiens (Human)) | BDBM50344040
(CHEMBL1780088 | trans-(3R,5R)-5-(methoxymethyl)-1-...)Show SMILES COC[C@@H]1C[C@H](CN(Cc2nc(oc2C)N2CCOCC2)C1)C(=O)NC[C@H]1CCCO1 |r| Show InChI InChI=1S/C22H36N4O5/c1-16-20(24-22(31-16)26-5-8-29-9-6-26)14-25-12-17(15-28-2)10-18(13-25)21(27)23-11-19-4-3-7-30-19/h17-19H,3-15H2,1-2H3,(H,23,27)/t17-,18-,19-/m1/s1 | Reactome pathway
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| n/a | n/a | 65 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of PDE8B |
Bioorg Med Chem Lett 21: 3095-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.022
BindingDB Entry DOI: 10.7270/Q20002F8 |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
(Homo sapiens (Human)) | BDBM50344041
(CHEMBL1780101 | trans-(3S,5S)-5-(5-methyl-1,3,4-ox...)Show SMILES Cc1nnc(o1)[C@H]1C[C@@H](CN(Cc2nc(oc2C)-c2ccccc2)C1)C(=O)NCc1cccc(C)n1 |r| Show InChI InChI=1S/C27H30N6O3/c1-17-8-7-11-23(29-17)13-28-25(34)21-12-22(27-32-31-19(3)36-27)15-33(14-21)16-24-18(2)35-26(30-24)20-9-5-4-6-10-20/h4-11,21-22H,12-16H2,1-3H3,(H,28,34)/t21-,22-/m0/s1 | Reactome pathway
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| n/a | n/a | 65.9 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of PDE8B |
Bioorg Med Chem Lett 21: 3095-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.022
BindingDB Entry DOI: 10.7270/Q20002F8 |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
(Homo sapiens (Human)) | BDBM50344042
(CHEMBL1780093 | trans-(3R,5R)-5-(5-methyl-1,3,4-ox...)Show SMILES Cc1nnc(o1)[C@@H]1C[C@H](CN(Cc2nc(oc2C)-c2ccccc2)C1)C(=O)NCc1cccc(C)n1 |r| Show InChI InChI=1S/C27H30N6O3/c1-17-8-7-11-23(29-17)13-28-25(34)21-12-22(27-32-31-19(3)36-27)15-33(14-21)16-24-18(2)35-26(30-24)20-9-5-4-6-10-20/h4-11,21-22H,12-16H2,1-3H3,(H,28,34)/t21-,22-/m1/s1 | Reactome pathway
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| n/a | n/a | 66 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of PDE8B |
Bioorg Med Chem Lett 21: 3095-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.022
BindingDB Entry DOI: 10.7270/Q20002F8 |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
(Homo sapiens (Human)) | BDBM50344043
(CHEMBL1779991 | trans-(3R,5R)-1-((5-methyl-2-pheny...)Show SMILES CCNC(=O)O[C@@H]1C[C@H](CN(Cc2nc(oc2C)-c2ccccc2)C1)C(=O)NCc1cccc(C)n1 |r| Show InChI InChI=1S/C27H33N5O4/c1-4-28-27(34)36-23-13-21(25(33)29-14-22-12-8-9-18(2)30-22)15-32(16-23)17-24-19(3)35-26(31-24)20-10-6-5-7-11-20/h5-12,21,23H,4,13-17H2,1-3H3,(H,28,34)(H,29,33)/t21-,23-/m1/s1 | Reactome pathway
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| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of PDE8B |
Bioorg Med Chem Lett 21: 3095-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.022
BindingDB Entry DOI: 10.7270/Q20002F8 |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
(Homo sapiens (Human)) | BDBM50344044
((R)-1-((5-methyl-2-phenyloxazol-4-yl)methyl)-N-(((...)Show SMILES Cc1oc(nc1CN1CCC[C@H](C1)C(=O)NC[C@H]1CCCO1)-c1ccccc1 |r| Show InChI InChI=1S/C22H29N3O3/c1-16-20(24-22(28-16)17-7-3-2-4-8-17)15-25-11-5-9-18(14-25)21(26)23-13-19-10-6-12-27-19/h2-4,7-8,18-19H,5-6,9-15H2,1H3,(H,23,26)/t18-,19-/m1/s1 | Reactome pathway
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PubMed
| n/a | n/a | 166 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of PDE8B |
Bioorg Med Chem Lett 21: 3095-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.022
BindingDB Entry DOI: 10.7270/Q20002F8 |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
(Homo sapiens (Human)) | BDBM50344045
(CHEMBL1780112 | trans-(3R,5R)-5-ethyl-1-((5-methyl...)Show SMILES CC[C@@H]1C[C@H](CN(Cc2nc(oc2C)N2CCOCC2)C1)C(=O)NCC1CCOCC1 |r| Show InChI InChI=1S/C23H38N4O4/c1-3-18-12-20(22(28)24-13-19-4-8-29-9-5-19)15-26(14-18)16-21-17(2)31-23(25-21)27-6-10-30-11-7-27/h18-20H,3-16H2,1-2H3,(H,24,28)/t18-,20-/m1/s1 | Reactome pathway
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| n/a | n/a | 168 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of PDE8B |
Bioorg Med Chem Lett 21: 3095-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.022
BindingDB Entry DOI: 10.7270/Q20002F8 |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
(Homo sapiens (Human)) | BDBM50344017
(1-((5-methyl-2-phenyloxazol-4-yl)methyl)-N-((6-met...)Show SMILES Cc1oc(nc1CN1CCCC(C1)C(=O)NCc1cccc(C)n1)-c1ccccc1 Show InChI InChI=1S/C24H28N4O2/c1-17-8-6-12-21(26-17)14-25-23(29)20-11-7-13-28(15-20)16-22-18(2)30-24(27-22)19-9-4-3-5-10-19/h3-6,8-10,12,20H,7,11,13-16H2,1-2H3,(H,25,29) | Reactome pathway
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| n/a | n/a | 240 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of PDE8B |
Bioorg Med Chem Lett 21: 3095-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.022
BindingDB Entry DOI: 10.7270/Q20002F8 |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
(Homo sapiens (Human)) | BDBM50344046
((R)-1-((5-methyl-2-phenyloxazol-4-yl)methyl)-N-(((...)Show SMILES Cc1oc(nc1CN1CCC[C@H](C1)C(=O)NC[C@@H]1CCCO1)-c1ccccc1 |r| Show InChI InChI=1S/C22H29N3O3/c1-16-20(24-22(28-16)17-7-3-2-4-8-17)15-25-11-5-9-18(14-25)21(26)23-13-19-10-6-12-27-19/h2-4,7-8,18-19H,5-6,9-15H2,1H3,(H,23,26)/t18-,19+/m1/s1 | Reactome pathway
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| n/a | n/a | 284 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of PDE8B |
Bioorg Med Chem Lett 21: 3095-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.022
BindingDB Entry DOI: 10.7270/Q20002F8 |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
(Homo sapiens (Human)) | BDBM50344047
(4-fluoro-2-((5-methyl-2-phenyloxazol-4-yl)methyl)-...)Show SMILES Cc1oc(nc1CN1Cc2ccccc2C(F)(C1)C(=O)NCc1cccc(C)n1)-c1ccccc1 Show InChI InChI=1S/C28H27FN4O2/c1-19-9-8-13-23(31-19)15-30-27(34)28(29)18-33(16-22-12-6-7-14-24(22)28)17-25-20(2)35-26(32-25)21-10-4-3-5-11-21/h3-14H,15-18H2,1-2H3,(H,30,34) | Reactome pathway
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| n/a | n/a | 370 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of PDE8B |
Bioorg Med Chem Lett 21: 3095-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.022
BindingDB Entry DOI: 10.7270/Q20002F8 |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
(Homo sapiens (Human)) | BDBM50344048
(CHEMBL1780099 | trans-1-((5-methyl-2-phenyloxazol-...)Show SMILES Cc1oc(nc1CN1CCCC(C1)C(=O)NCC1CCOCC1)-c1ccccc1 Show InChI InChI=1S/C23H31N3O3/c1-17-21(25-23(29-17)19-6-3-2-4-7-19)16-26-11-5-8-20(15-26)22(27)24-14-18-9-12-28-13-10-18/h2-4,6-7,18,20H,5,8-16H2,1H3,(H,24,27) | Reactome pathway
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| n/a | n/a | 516 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of PDE8B |
Bioorg Med Chem Lett 21: 3095-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.022
BindingDB Entry DOI: 10.7270/Q20002F8 |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
(Homo sapiens (Human)) | BDBM50344049
(CHEMBL1780117 | cis-(3R,5S)-5-ethyl-1-((5-methyl-2...)Show SMILES CC[C@H]1C[C@H](CN(Cc2nc(oc2C)-c2ccccc2)C1)C(=O)NC[C@H]1CCCO1 |r| Show InChI InChI=1S/C24H33N3O3/c1-3-18-12-20(23(28)25-13-21-10-7-11-29-21)15-27(14-18)16-22-17(2)30-24(26-22)19-8-5-4-6-9-19/h4-6,8-9,18,20-21H,3,7,10-16H2,1-2H3,(H,25,28)/t18-,20+,21+/m0/s1 | Reactome pathway
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| n/a | n/a | 675 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of PDE8B |
Bioorg Med Chem Lett 21: 3095-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.022
BindingDB Entry DOI: 10.7270/Q20002F8 |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
(Homo sapiens (Human)) | BDBM50344050
(CHEMBL1780108 | trans-(3R,5R)-5-ethyl-1-((5-methyl...)Show SMILES CC[C@@H]1C[C@H](CN(Cc2nc(oc2C)N2CCOCC2)C1)C(=O)NC[C@@H]1CCCO1 |r| Show InChI InChI=1S/C22H36N4O4/c1-3-17-11-18(21(27)23-12-19-5-4-8-29-19)14-25(13-17)15-20-16(2)30-22(24-20)26-6-9-28-10-7-26/h17-19H,3-15H2,1-2H3,(H,23,27)/t17-,18-,19+/m1/s1 | Reactome pathway
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| n/a | n/a | 707 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of PDE8B |
Bioorg Med Chem Lett 21: 3095-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.022
BindingDB Entry DOI: 10.7270/Q20002F8 |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
(Homo sapiens (Human)) | BDBM50344051
(CHEMBL1779982 | trans-(3R,4R)-1-((5-methyl-2-pheny...)Show SMILES Cc1oc(nc1CN1C[C@@H]([C@H](C1)C(F)(F)F)C(=O)NCc1cccc(C)n1)-c1ccccc1 |r| Show InChI InChI=1S/C24H25F3N4O2/c1-15-7-6-10-18(29-15)11-28-22(32)19-12-31(13-20(19)24(25,26)27)14-21-16(2)33-23(30-21)17-8-4-3-5-9-17/h3-10,19-20H,11-14H2,1-2H3,(H,28,32)/t19-,20-/m0/s1 | Reactome pathway
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| n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of PDE8B |
Bioorg Med Chem Lett 21: 3095-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.022
BindingDB Entry DOI: 10.7270/Q20002F8 |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
(Homo sapiens (Human)) | BDBM50344003
(CHEMBL1780110 | cis-(3R,5S)-N-((6-aminopyridin-2-y...)Show SMILES CC[C@H]1C[C@H](CN(Cc2nc(oc2C)N2CCOCC2)C1)C(=O)NCc1cccc(N)n1 |r| Show InChI InChI=1S/C23H34N6O3/c1-3-17-11-18(22(30)25-12-19-5-4-6-21(24)26-19)14-28(13-17)15-20-16(2)32-23(27-20)29-7-9-31-10-8-29/h4-6,17-18H,3,7-15H2,1-2H3,(H2,24,26)(H,25,30)/t17-,18+/m0/s1 | Reactome pathway
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| n/a | n/a | >2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of PDE8B |
Bioorg Med Chem Lett 21: 3095-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.022
BindingDB Entry DOI: 10.7270/Q20002F8 |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
(Homo sapiens (Human)) | BDBM50344004
(CHEMBL1780114 | cis-(3R,5S)-5-ethyl-1-((5-methyl-2...)Show SMILES CC[C@H]1C[C@H](CN(Cc2nc(oc2C)-c2ccccc2)C1)C(=O)NCC1CCOCC1 |r| Show InChI InChI=1S/C25H35N3O3/c1-3-19-13-22(24(29)26-14-20-9-11-30-12-10-20)16-28(15-19)17-23-18(2)31-25(27-23)21-7-5-4-6-8-21/h4-8,19-20,22H,3,9-17H2,1-2H3,(H,26,29)/t19-,22+/m0/s1 | Reactome pathway
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| n/a | n/a | >2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of PDE8B |
Bioorg Med Chem Lett 21: 3095-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.022
BindingDB Entry DOI: 10.7270/Q20002F8 |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
(Homo sapiens (Human)) | BDBM50344001
(CHEMBL1780095 | cis-(3R,5S)-5-ethyl-1-((5-methyl-2...)Show SMILES CC[C@H]1C[C@H](CN(Cc2nc(oc2C)-c2ccccc2)C1)C(=O)NCc1cccc(C)n1 |r| Show InChI InChI=1S/C26H32N4O2/c1-4-20-13-22(25(31)27-14-23-12-8-9-18(2)28-23)16-30(15-20)17-24-19(3)32-26(29-24)21-10-6-5-7-11-21/h5-12,20,22H,4,13-17H2,1-3H3,(H,27,31)/t20-,22+/m0/s1 | Reactome pathway
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| n/a | n/a | >2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of PDE8B |
Bioorg Med Chem Lett 21: 3095-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.022
BindingDB Entry DOI: 10.7270/Q20002F8 |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
(Homo sapiens (Human)) | BDBM50344002
(CHEMBL1780098 | cis-(3R,5S)-5-(methoxymethyl)-1-((...)Show SMILES COC[C@H]1C[C@H](CN(Cc2nc(oc2C)-c2ccccc2)C1)C(=O)NCc1cccc(C)n1 |r| Show InChI InChI=1S/C26H32N4O3/c1-18-8-7-11-23(28-18)13-27-25(31)22-12-20(17-32-3)14-30(15-22)16-24-19(2)33-26(29-24)21-9-5-4-6-10-21/h4-11,20,22H,12-17H2,1-3H3,(H,27,31)/t20-,22+/m0/s1 | Reactome pathway
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| n/a | n/a | >2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of PDE8B |
Bioorg Med Chem Lett 21: 3095-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.022
BindingDB Entry DOI: 10.7270/Q20002F8 |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
(Homo sapiens (Human)) | BDBM50344052
(4-(5-Methyl-2-phenyl-oxazol-4-ylmethyl)-1,1-dioxo-...)Show SMILES Cc1oc(nc1CN1CCS(=O)(=O)C(C1)C(=O)NCc1cccc(C)n1)-c1ccccc1 Show InChI InChI=1S/C23H26N4O4S/c1-16-7-6-10-19(25-16)13-24-22(28)21-15-27(11-12-32(21,29)30)14-20-17(2)31-23(26-20)18-8-4-3-5-9-18/h3-10,21H,11-15H2,1-2H3,(H,24,28) | Reactome pathway
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| n/a | n/a | 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of PDE8B |
Bioorg Med Chem Lett 21: 3095-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.022
BindingDB Entry DOI: 10.7270/Q20002F8 |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
(Homo sapiens (Human)) | BDBM50344053
(CHEMBL1779989 | trans-(3R,5R)-5-hydroxy-1-((5-meth...)Show SMILES Cc1oc(nc1CN1C[C@H](O)C[C@H](C1)C(=O)NCc1cccc(C)n1)-c1ccccc1 |r| Show InChI InChI=1S/C24H28N4O3/c1-16-7-6-10-20(26-16)12-25-23(30)19-11-21(29)14-28(13-19)15-22-17(2)31-24(27-22)18-8-4-3-5-9-18/h3-10,19,21,29H,11-15H2,1-2H3,(H,25,30)/t19-,21-/m1/s1 | Reactome pathway
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| n/a | n/a | 2.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of PDE8B |
Bioorg Med Chem Lett 21: 3095-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.022
BindingDB Entry DOI: 10.7270/Q20002F8 |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
(Homo sapiens (Human)) | BDBM50344005
(CHEMBL1780106 | cis-(3R,5S)-5-(methoxymethyl)-1-((...)Show SMILES COC[C@H]1C[C@H](CN(Cc2nc(oc2C)-c2ccccc2)C1)C(=O)NC[C@H]1CCCO1 |r| Show InChI InChI=1S/C24H33N3O4/c1-17-22(26-24(31-17)19-7-4-3-5-8-19)15-27-13-18(16-29-2)11-20(14-27)23(28)25-12-21-9-6-10-30-21/h3-5,7-8,18,20-21H,6,9-16H2,1-2H3,(H,25,28)/t18-,20+,21+/m0/s1 | Reactome pathway
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of PDE8B |
Bioorg Med Chem Lett 21: 3095-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.022
BindingDB Entry DOI: 10.7270/Q20002F8 |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
(Homo sapiens (Human)) | BDBM50344008
(CHEMBL1780113 | cis-(3R,5S)-5-ethyl-1-((5-methyl-2...)Show SMILES CC[C@H]1C[C@H](CN(Cc2nc(oc2C)N2CCOCC2)C1)C(=O)NCC1CCOCC1 |r| Show InChI InChI=1S/C23H38N4O4/c1-3-18-12-20(22(28)24-13-19-4-8-29-9-5-19)15-26(14-18)16-21-17(2)31-23(25-21)27-6-10-30-11-7-27/h18-20H,3-16H2,1-2H3,(H,24,28)/t18-,20+/m0/s1 | Reactome pathway
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of PDE8B |
Bioorg Med Chem Lett 21: 3095-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.022
BindingDB Entry DOI: 10.7270/Q20002F8 |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
(Homo sapiens (Human)) | BDBM50344009
(CHEMBL1780119 | cis-(3R,5S)-5-(methoxymethyl)-1-((...)Show SMILES COC[C@H]1C[C@H](CN(Cc2nc(oc2C)N2CCOCC2)C1)C(=O)NCC1CCOCC1 |r| Show InChI InChI=1S/C23H38N4O5/c1-17-21(25-23(32-17)27-5-9-31-10-6-27)15-26-13-19(16-29-2)11-20(14-26)22(28)24-12-18-3-7-30-8-4-18/h18-20H,3-16H2,1-2H3,(H,24,28)/t19-,20+/m0/s1 | Reactome pathway
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| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of PDE8B |
Bioorg Med Chem Lett 21: 3095-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.022
BindingDB Entry DOI: 10.7270/Q20002F8 |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
(Homo sapiens (Human)) | BDBM50344000
(5-(methoxymethyl)-1-((5-methyl-2-morpholinooxazol-...)Show SMILES COCC1CC(CN(Cc2nc(oc2C)N2CCOCC2)C1)C(=O)NC[C@H]1CCCO1 |r| Show InChI InChI=1S/C22H36N4O5/c1-16-20(24-22(31-16)26-5-8-29-9-6-26)14-25-12-17(15-28-2)10-18(13-25)21(27)23-11-19-4-3-7-30-19/h17-19H,3-15H2,1-2H3,(H,23,27)/t17?,18?,19-/m1/s1 | Reactome pathway
KEGG
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of PDE8B |
Bioorg Med Chem Lett 21: 3095-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.022
BindingDB Entry DOI: 10.7270/Q20002F8 |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
(Homo sapiens (Human)) | BDBM50344007
(CHEMBL1780109 | cis-(3R,5S)-5-ethyl-1-((5-methyl-2...)Show SMILES CC[C@H]1C[C@H](CN(Cc2nc(oc2C)N2CCOCC2)C1)C(=O)NC[C@@H]1CCCO1 |r| Show InChI InChI=1S/C22H36N4O4/c1-3-17-11-18(21(27)23-12-19-5-4-8-29-19)14-25(13-17)15-20-16(2)30-22(24-20)26-6-9-28-10-7-26/h17-19H,3-15H2,1-2H3,(H,23,27)/t17-,18+,19-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
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antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of PDE8B |
Bioorg Med Chem Lett 21: 3095-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.022
BindingDB Entry DOI: 10.7270/Q20002F8 |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
(Homo sapiens (Human)) | BDBM50344006
(CHEMBL1780107 | cis-(3R,5S)-5-(methoxymethyl)-1-((...)Show SMILES COC[C@H]1C[C@H](CN(Cc2nc(oc2C)N2CCOCC2)C1)C(=O)NC[C@H]1CCCO1 |r| Show InChI InChI=1S/C22H36N4O5/c1-16-20(24-22(31-16)26-5-8-29-9-6-26)14-25-12-17(15-28-2)10-18(13-25)21(27)23-11-19-4-3-7-30-19/h17-19H,3-15H2,1-2H3,(H,23,27)/t17-,18+,19+/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
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antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of PDE8B |
Bioorg Med Chem Lett 21: 3095-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.022
BindingDB Entry DOI: 10.7270/Q20002F8 |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
(Homo sapiens (Human)) | BDBM50344010
(CHEMBL1780120 | cis-(3R,5S)-5-(methoxymethyl)-1-((...)Show SMILES COC[C@H]1C[C@H](CN(Cc2[nH]c(nc2C)-c2ccncn2)C1)C(=O)NCC1CCOCC1 |r| Show InChI InChI=1S/C23H34N6O3/c1-16-21(28-22(27-16)20-3-6-24-15-26-20)13-29-11-18(14-31-2)9-19(12-29)23(30)25-10-17-4-7-32-8-5-17/h3,6,15,17-19H,4-5,7-14H2,1-2H3,(H,25,30)(H,27,28)/t18-,19+/m0/s1 | Reactome pathway
KEGG
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of PDE8B |
Bioorg Med Chem Lett 21: 3095-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.022
BindingDB Entry DOI: 10.7270/Q20002F8 |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
(Homo sapiens (Human)) | BDBM50344000
(5-(methoxymethyl)-1-((5-methyl-2-morpholinooxazol-...)Show SMILES COCC1CC(CN(Cc2nc(oc2C)N2CCOCC2)C1)C(=O)NC[C@H]1CCCO1 |r| Show InChI InChI=1S/C22H36N4O5/c1-16-20(24-22(31-16)26-5-8-29-9-6-26)14-25-12-17(15-28-2)10-18(13-25)21(27)23-11-19-4-3-7-30-19/h17-19H,3-15H2,1-2H3,(H,23,27)/t17?,18?,19-/m1/s1 | Reactome pathway
KEGG
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antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of PDE8B |
Bioorg Med Chem Lett 21: 3095-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.022
BindingDB Entry DOI: 10.7270/Q20002F8 |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
(Homo sapiens (Human)) | BDBM50344000
(5-(methoxymethyl)-1-((5-methyl-2-morpholinooxazol-...)Show SMILES COCC1CC(CN(Cc2nc(oc2C)N2CCOCC2)C1)C(=O)NC[C@H]1CCCO1 |r| Show InChI InChI=1S/C22H36N4O5/c1-16-20(24-22(31-16)26-5-8-29-9-6-26)14-25-12-17(15-28-2)10-18(13-25)21(27)23-11-19-4-3-7-30-19/h17-19H,3-15H2,1-2H3,(H,23,27)/t17?,18?,19-/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of PDE8B |
Bioorg Med Chem Lett 21: 3095-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.022
BindingDB Entry DOI: 10.7270/Q20002F8 |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
(Homo sapiens (Human)) | BDBM50344011
(4-((5-methyl-2-phenyloxazol-4-yl)methyl)-N-((6-met...)Show SMILES Cc1oc(nc1CN1CCOC(C1)C(=O)NCc1cccc(C)n1)-c1ccccc1 Show InChI InChI=1S/C23H26N4O3/c1-16-7-6-10-19(25-16)13-24-22(28)21-15-27(11-12-29-21)14-20-17(2)30-23(26-20)18-8-4-3-5-9-18/h3-10,21H,11-15H2,1-2H3,(H,24,28) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
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GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of PDE8B |
Bioorg Med Chem Lett 21: 3095-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.022
BindingDB Entry DOI: 10.7270/Q20002F8 |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
(Homo sapiens (Human)) | BDBM50344012
((R)-1-((5-methyl-2-phenyloxazol-4-yl)methyl)-N-((6...)Show SMILES Cc1oc(nc1CN1CC[C@H](C1)C(=O)NCc1cccc(C)n1)-c1ccccc1 |r| Show InChI InChI=1S/C23H26N4O2/c1-16-7-6-10-20(25-16)13-24-22(28)19-11-12-27(14-19)15-21-17(2)29-23(26-21)18-8-4-3-5-9-18/h3-10,19H,11-15H2,1-2H3,(H,24,28)/t19-/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of PDE8B |
Bioorg Med Chem Lett 21: 3095-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.022
BindingDB Entry DOI: 10.7270/Q20002F8 |
More data for this
Ligand-Target Pair | |
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