Found 77 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM50345259
(CHEMBL1782530 | cis-7-(4-aminocyclohexylamino)-5-b...)Show SMILES N[C@H]1CC[C@H](CC1)Nc1cc(Br)cc2cc(oc12)C(O)=O |r,wU:4.7,1.0,(33.37,-17.22,;34.71,-16.45,;34.71,-14.91,;36.04,-14.15,;37.36,-14.92,;37.38,-16.46,;36.04,-17.22,;38.7,-14.15,;38.69,-12.61,;37.36,-11.84,;37.36,-10.3,;36.03,-9.53,;38.69,-9.53,;40.02,-10.29,;41.49,-9.81,;42.4,-11.05,;41.5,-12.3,;40.03,-11.83,;43.94,-11.04,;44.72,-12.37,;44.7,-9.7,)| Show InChI InChI=1S/C15H17BrN2O3/c16-9-5-8-6-13(15(19)20)21-14(8)12(7-9)18-11-3-1-10(17)2-4-11/h5-7,10-11,18H,1-4,17H2,(H,19,20)/t10-,11+ | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift method |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50345259
(CHEMBL1782530 | cis-7-(4-aminocyclohexylamino)-5-b...)Show SMILES N[C@H]1CC[C@H](CC1)Nc1cc(Br)cc2cc(oc12)C(O)=O |r,wU:4.7,1.0,(33.37,-17.22,;34.71,-16.45,;34.71,-14.91,;36.04,-14.15,;37.36,-14.92,;37.38,-16.46,;36.04,-17.22,;38.7,-14.15,;38.69,-12.61,;37.36,-11.84,;37.36,-10.3,;36.03,-9.53,;38.69,-9.53,;40.02,-10.29,;41.49,-9.81,;42.4,-11.05,;41.5,-12.3,;40.03,-11.83,;43.94,-11.04,;44.72,-12.37,;44.7,-9.7,)| Show InChI InChI=1S/C15H17BrN2O3/c16-9-5-8-6-13(15(19)20)21-14(8)12(7-9)18-11-3-1-10(17)2-4-11/h5-7,10-11,18H,1-4,17H2,(H,19,20)/t10-,11+ | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift method |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM50345260
(CHEMBL1782531 | trans-7-(4-aminocyclohexylamino)-5...)Show SMILES N[C@H]1CC[C@@H](CC1)Nc1cc(Br)cc2cc(oc12)C(O)=O |r,wU:1.0,wD:4.7,(48.98,-16.4,;50.31,-15.63,;50.32,-14.09,;51.64,-13.33,;52.97,-14.1,;52.98,-15.64,;51.64,-16.4,;54.3,-13.33,;54.3,-11.79,;52.96,-11.02,;52.97,-9.48,;51.63,-8.71,;54.29,-8.71,;55.63,-9.47,;57.09,-8.99,;58,-10.23,;57.1,-11.48,;55.64,-11.01,;59.54,-10.22,;60.32,-11.55,;60.3,-8.88,)| Show InChI InChI=1S/C15H17BrN2O3/c16-9-5-8-6-13(15(19)20)21-14(8)12(7-9)18-11-3-1-10(17)2-4-11/h5-7,10-11,18H,1-4,17H2,(H,19,20)/t10-,11- | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift method |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM50345250
(5-bromo-7-(piperidin-4-ylmethylamino)benzofuran-2-...)Show InChI InChI=1S/C15H17BrN2O3/c16-11-5-10-6-13(15(19)20)21-14(10)12(7-11)18-8-9-1-3-17-4-2-9/h5-7,9,17-18H,1-4,8H2,(H,19,20) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift method |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50345245
(CHEMBL1782516 | trans-5-(6-(4-(aminomethyl)cyclohe...)Show SMILES NC[C@H]1CC[C@@H](CC1)Nc1cncc(n1)-c1ccc2oc(cc2c1)C(O)=O |r,wU:5.8,wD:2.1,(-10.87,-26.04,;-9.53,-25.27,;-8.19,-26.04,;-8.19,-27.58,;-6.85,-28.36,;-5.52,-27.57,;-5.53,-26.04,;-6.86,-25.28,;-4.19,-28.34,;-2.86,-27.56,;-2.86,-26.02,;-1.53,-25.25,;-.2,-26.02,;-.2,-27.56,;-1.53,-28.33,;1.13,-28.32,;1.13,-29.87,;2.46,-30.64,;3.8,-29.86,;5.26,-30.33,;6.16,-29.08,;5.25,-27.83,;3.79,-28.32,;2.46,-27.56,;7.7,-29.07,;8.48,-30.39,;8.46,-27.73,)| Show InChI InChI=1S/C20H22N4O3/c21-9-12-1-4-15(5-2-12)23-19-11-22-10-16(24-19)13-3-6-17-14(7-13)8-18(27-17)20(25)26/h3,6-8,10-12,15H,1-2,4-5,9,21H2,(H,23,24)(H,25,26)/t12-,15- | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift method |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM50345253
(5-bromo-7-(2-(piperidin-4-yl)ethylamino)benzofuran...)Show InChI InChI=1S/C16H19BrN2O3/c17-12-7-11-8-14(16(20)21)22-15(11)13(9-12)19-6-3-10-1-4-18-5-2-10/h7-10,18-19H,1-6H2,(H,20,21) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift method |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM50345251
(5-bromo-7-(2-(piperidin-4-yl)ethoxy)benzofuran-2-c...)Show InChI InChI=1S/C16H18BrNO4/c17-12-7-11-8-14(16(19)20)22-15(11)13(9-12)21-6-3-10-1-4-18-5-2-10/h7-10,18H,1-6H2,(H,19,20) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 51 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift method |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM50345245
(CHEMBL1782516 | trans-5-(6-(4-(aminomethyl)cyclohe...)Show SMILES NC[C@H]1CC[C@@H](CC1)Nc1cncc(n1)-c1ccc2oc(cc2c1)C(O)=O |r,wU:5.8,wD:2.1,(-10.87,-26.04,;-9.53,-25.27,;-8.19,-26.04,;-8.19,-27.58,;-6.85,-28.36,;-5.52,-27.57,;-5.53,-26.04,;-6.86,-25.28,;-4.19,-28.34,;-2.86,-27.56,;-2.86,-26.02,;-1.53,-25.25,;-.2,-26.02,;-.2,-27.56,;-1.53,-28.33,;1.13,-28.32,;1.13,-29.87,;2.46,-30.64,;3.8,-29.86,;5.26,-30.33,;6.16,-29.08,;5.25,-27.83,;3.79,-28.32,;2.46,-27.56,;7.7,-29.07,;8.48,-30.39,;8.46,-27.73,)| Show InChI InChI=1S/C20H22N4O3/c21-9-12-1-4-15(5-2-12)23-19-11-22-10-16(24-19)13-3-6-17-14(7-13)8-18(27-17)20(25)26/h3,6-8,10-12,15H,1-2,4-5,9,21H2,(H,23,24)(H,25,26)/t12-,15- | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 53 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift method |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50345242
(CHEMBL1782513 | trans-5-(6-(4-aminocyclohexylamino...)Show SMILES N[C@H]1CC[C@@H](CC1)Nc1cncc(n1)-c1ccc2oc(cc2c1)C(O)=O |r,wU:4.7,wD:1.0,(18.96,-16.61,;20.29,-17.38,;20.29,-18.92,;21.63,-19.69,;22.95,-18.91,;22.95,-17.38,;21.62,-16.61,;24.29,-19.68,;25.62,-18.9,;25.61,-17.36,;26.94,-16.59,;28.28,-17.36,;28.27,-18.9,;26.95,-19.66,;29.6,-19.66,;29.6,-21.21,;30.93,-21.98,;32.27,-21.2,;33.74,-21.67,;34.64,-20.41,;33.72,-19.17,;32.26,-19.66,;30.93,-18.89,;36.18,-20.41,;36.95,-21.73,;36.94,-19.07,)| Show InChI InChI=1S/C19H20N4O3/c20-13-2-4-14(5-3-13)22-18-10-21-9-15(23-18)11-1-6-16-12(7-11)8-17(26-16)19(24)25/h1,6-10,13-14H,2-5,20H2,(H,22,23)(H,24,25)/t13-,14- | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 54 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift method |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM50345255
(5-bromo-7-(2-(piperidin-4-yl)acetamido)benzofuran-...)Show InChI InChI=1S/C16H17BrN2O4/c17-11-6-10-7-13(16(21)22)23-15(10)12(8-11)19-14(20)5-9-1-3-18-4-2-9/h6-9,18H,1-5H2,(H,19,20)(H,21,22) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift method |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM50345247
(5-bromo-7-(piperidin-4-ylmethoxy)benzofuran-2-carb...)Show InChI InChI=1S/C15H16BrNO4/c16-11-5-10-6-13(15(18)19)21-14(10)12(7-11)20-8-9-1-3-17-4-2-9/h5-7,9,17H,1-4,8H2,(H,18,19) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift method |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50345260
(CHEMBL1782531 | trans-7-(4-aminocyclohexylamino)-5...)Show SMILES N[C@H]1CC[C@@H](CC1)Nc1cc(Br)cc2cc(oc12)C(O)=O |r,wU:1.0,wD:4.7,(48.98,-16.4,;50.31,-15.63,;50.32,-14.09,;51.64,-13.33,;52.97,-14.1,;52.98,-15.64,;51.64,-16.4,;54.3,-13.33,;54.3,-11.79,;52.96,-11.02,;52.97,-9.48,;51.63,-8.71,;54.29,-8.71,;55.63,-9.47,;57.09,-8.99,;58,-10.23,;57.1,-11.48,;55.64,-11.01,;59.54,-10.22,;60.32,-11.55,;60.3,-8.88,)| Show InChI InChI=1S/C15H17BrN2O3/c16-9-5-8-6-13(15(19)20)21-14(8)12(7-9)18-11-3-1-10(17)2-4-11/h5-7,10-11,18H,1-4,17H2,(H,19,20)/t10-,11- | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 66 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift method |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM50345249
(5-bromo-7-(piperidin-3-ylmethoxy)benzofuran-2-carb...)Show InChI InChI=1S/C15H16BrNO4/c16-11-4-10-5-13(15(18)19)21-14(10)12(6-11)20-8-9-2-1-3-17-7-9/h4-6,9,17H,1-3,7-8H2,(H,18,19) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 71 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift method |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50345246
(5-(6-(azetidin-3-ylamino)pyrazin-2-yl)benzofuran-2...)Show InChI InChI=1S/C16H14N4O3/c21-16(22)14-4-10-3-9(1-2-13(10)23-14)12-7-18-8-15(20-12)19-11-5-17-6-11/h1-4,7-8,11,17H,5-6H2,(H,19,20)(H,21,22) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift method |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50345243
(CHEMBL1782514 | cis-5-(6-(4-aminocyclohexylamino)p...)Show SMILES N[C@H]1CC[C@H](CC1)Nc1cncc(n1)-c1ccc2oc(cc2c1)C(O)=O |r,wD:4.7,1.0,(37.06,-16.23,;38.39,-17,;38.39,-18.54,;39.73,-19.31,;41.06,-18.53,;41.05,-16.99,;39.73,-16.23,;42.39,-19.29,;43.72,-18.52,;43.71,-16.97,;45.05,-16.2,;46.38,-16.97,;46.38,-18.51,;45.05,-19.28,;47.71,-19.28,;47.7,-20.82,;49.04,-21.59,;50.38,-20.81,;51.84,-21.28,;52.74,-20.03,;51.83,-18.79,;50.37,-19.27,;49.03,-18.51,;54.28,-20.02,;55.06,-21.35,;55.04,-18.68,)| Show InChI InChI=1S/C19H20N4O3/c20-13-2-4-14(5-3-13)22-18-10-21-9-15(23-18)11-1-6-16-12(7-11)8-17(26-16)19(24)25/h1,6-10,13-14H,2-5,20H2,(H,22,23)(H,24,25)/t13-,14+ | PDB
MMDB
KEGG
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B.MOAD
antibodypedia
GoogleScholar
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| CHEMBL
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PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift method |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM50345242
(CHEMBL1782513 | trans-5-(6-(4-aminocyclohexylamino...)Show SMILES N[C@H]1CC[C@@H](CC1)Nc1cncc(n1)-c1ccc2oc(cc2c1)C(O)=O |r,wU:4.7,wD:1.0,(18.96,-16.61,;20.29,-17.38,;20.29,-18.92,;21.63,-19.69,;22.95,-18.91,;22.95,-17.38,;21.62,-16.61,;24.29,-19.68,;25.62,-18.9,;25.61,-17.36,;26.94,-16.59,;28.28,-17.36,;28.27,-18.9,;26.95,-19.66,;29.6,-19.66,;29.6,-21.21,;30.93,-21.98,;32.27,-21.2,;33.74,-21.67,;34.64,-20.41,;33.72,-19.17,;32.26,-19.66,;30.93,-18.89,;36.18,-20.41,;36.95,-21.73,;36.94,-19.07,)| Show InChI InChI=1S/C19H20N4O3/c20-13-2-4-14(5-3-13)22-18-10-21-9-15(23-18)11-1-6-16-12(7-11)8-17(26-16)19(24)25/h1,6-10,13-14H,2-5,20H2,(H,22,23)(H,24,25)/t13-,14- | PDB
MMDB
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UniProtKB/SwissProt
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DrugBank
antibodypedia
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| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift method |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50345244
(5-(6-(piperidin-4-ylamino)pyrazin-2-yl)benzofuran-...)Show InChI InChI=1S/C18H18N4O3/c23-18(24)16-8-12-7-11(1-2-15(12)25-16)14-9-20-10-17(22-14)21-13-3-5-19-6-4-13/h1-2,7-10,13,19H,3-6H2,(H,21,22)(H,23,24) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift method |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM50345254
(5-bromo-7-(piperidine-4-carboxamido)benzofuran-2-c...)Show InChI InChI=1S/C15H15BrN2O4/c16-10-5-9-6-12(15(20)21)22-13(9)11(7-10)18-14(19)8-1-3-17-4-2-8/h5-8,17H,1-4H2,(H,18,19)(H,20,21) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift method |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50345238
(5-(6-(piperidin-4-ylmethylamino)pyrazin-2-yl)benzo...)Show InChI InChI=1S/C19H20N4O3/c24-19(25)17-8-14-7-13(1-2-16(14)26-17)15-10-21-11-18(23-15)22-9-12-3-5-20-6-4-12/h1-2,7-8,10-12,20H,3-6,9H2,(H,22,23)(H,24,25) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift method |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50345250
(5-bromo-7-(piperidin-4-ylmethylamino)benzofuran-2-...)Show InChI InChI=1S/C15H17BrN2O3/c16-11-5-10-6-13(15(19)20)21-14(10)12(7-11)18-8-9-1-3-17-4-2-9/h5-7,9,17-18H,1-4,8H2,(H,19,20) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift method |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM50345243
(CHEMBL1782514 | cis-5-(6-(4-aminocyclohexylamino)p...)Show SMILES N[C@H]1CC[C@H](CC1)Nc1cncc(n1)-c1ccc2oc(cc2c1)C(O)=O |r,wD:4.7,1.0,(37.06,-16.23,;38.39,-17,;38.39,-18.54,;39.73,-19.31,;41.06,-18.53,;41.05,-16.99,;39.73,-16.23,;42.39,-19.29,;43.72,-18.52,;43.71,-16.97,;45.05,-16.2,;46.38,-16.97,;46.38,-18.51,;45.05,-19.28,;47.71,-19.28,;47.7,-20.82,;49.04,-21.59,;50.38,-20.81,;51.84,-21.28,;52.74,-20.03,;51.83,-18.79,;50.37,-19.27,;49.03,-18.51,;54.28,-20.02,;55.06,-21.35,;55.04,-18.68,)| Show InChI InChI=1S/C19H20N4O3/c20-13-2-4-14(5-3-13)22-18-10-21-9-15(23-18)11-1-6-16-12(7-11)8-17(26-16)19(24)25/h1,6-10,13-14H,2-5,20H2,(H,22,23)(H,24,25)/t13-,14+ | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift method |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM50345244
(5-(6-(piperidin-4-ylamino)pyrazin-2-yl)benzofuran-...)Show InChI InChI=1S/C18H18N4O3/c23-18(24)16-8-12-7-11(1-2-15(12)25-16)14-9-20-10-17(22-14)21-13-3-5-19-6-4-13/h1-2,7-10,13,19H,3-6H2,(H,21,22)(H,23,24) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 210 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift method |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM50345256
(5-bromo-7-(2-oxo-2-(piperazin-1-yl)ethoxy)benzofur...)Show InChI InChI=1S/C15H15BrN2O5/c16-10-5-9-6-12(15(20)21)23-14(9)11(7-10)22-8-13(19)18-3-1-17-2-4-18/h5-7,17H,1-4,8H2,(H,20,21) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 220 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift method |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50345247
(5-bromo-7-(piperidin-4-ylmethoxy)benzofuran-2-carb...)Show InChI InChI=1S/C15H16BrNO4/c16-11-5-10-6-13(15(18)19)21-14(10)12(7-11)20-8-9-1-3-17-4-2-9/h5-7,9,17H,1-4,8H2,(H,18,19) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift method |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50345254
(5-bromo-7-(piperidine-4-carboxamido)benzofuran-2-c...)Show InChI InChI=1S/C15H15BrN2O4/c16-10-5-9-6-12(15(20)21)22-13(9)11(7-10)18-14(19)8-1-3-17-4-2-8/h5-8,17H,1-4H2,(H,18,19)(H,20,21) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 260 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift method |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50345249
(5-bromo-7-(piperidin-3-ylmethoxy)benzofuran-2-carb...)Show InChI InChI=1S/C15H16BrNO4/c16-11-4-10-5-13(15(18)19)21-14(10)12(6-11)20-8-9-2-1-3-17-7-9/h4-6,9,17H,1-3,7-8H2,(H,18,19) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 330 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift method |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50345255
(5-bromo-7-(2-(piperidin-4-yl)acetamido)benzofuran-...)Show InChI InChI=1S/C16H17BrN2O4/c17-11-6-10-7-13(16(21)22)23-15(10)12(8-11)19-14(20)5-9-1-3-18-4-2-9/h6-9,18H,1-5H2,(H,19,20)(H,21,22) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 340 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift method |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50345251
(5-bromo-7-(2-(piperidin-4-yl)ethoxy)benzofuran-2-c...)Show InChI InChI=1S/C16H18BrNO4/c17-12-7-11-8-14(16(19)20)22-15(11)13(9-12)21-6-3-10-1-4-18-5-2-10/h7-10,18H,1-6H2,(H,19,20) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 350 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift method |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM50345238
(5-(6-(piperidin-4-ylmethylamino)pyrazin-2-yl)benzo...)Show InChI InChI=1S/C19H20N4O3/c24-19(25)17-8-14-7-13(1-2-16(14)26-17)15-10-21-11-18(23-15)22-9-12-3-5-20-6-4-12/h1-2,7-8,10-12,20H,3-6,9H2,(H,22,23)(H,24,25) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 380 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift method |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM50345246
(5-(6-(azetidin-3-ylamino)pyrazin-2-yl)benzofuran-2...)Show InChI InChI=1S/C16H14N4O3/c21-16(22)14-4-10-3-9(1-2-13(10)23-14)12-7-18-8-15(20-12)19-11-5-17-6-11/h1-4,7-8,11,17H,5-6H2,(H,19,20)(H,21,22) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 450 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift method |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM50345241
(5-(2-(4-aminobutylamino)pyrimidin-4-yl)benzofuran-...)Show InChI InChI=1S/C17H18N4O3/c18-6-1-2-7-19-17-20-8-5-13(21-17)11-3-4-14-12(9-11)10-15(24-14)16(22)23/h3-5,8-10H,1-2,6-7,18H2,(H,22,23)(H,19,20,21) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 460 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift method |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50345253
(5-bromo-7-(2-(piperidin-4-yl)ethylamino)benzofuran...)Show InChI InChI=1S/C16H19BrN2O3/c17-12-7-11-8-14(16(20)21)22-15(11)13(9-12)19-6-3-10-1-4-18-5-2-10/h7-10,18-19H,1-6H2,(H,20,21) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 540 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift method |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50345241
(5-(2-(4-aminobutylamino)pyrimidin-4-yl)benzofuran-...)Show InChI InChI=1S/C17H18N4O3/c18-6-1-2-7-19-17-20-8-5-13(21-17)11-3-4-14-12(9-11)10-15(24-14)16(22)23/h3-5,8-10H,1-2,6-7,18H2,(H,22,23)(H,19,20,21) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 590 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift method |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM50345257
(5-bromo-7-(piperidin-4-ylcarbamoyl)benzofuran-2-ca...)Show InChI InChI=1S/C15H15BrN2O4/c16-9-5-8-6-12(15(20)21)22-13(8)11(7-9)14(19)18-10-1-3-17-4-2-10/h5-7,10,17H,1-4H2,(H,18,19)(H,20,21) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 980 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift method |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50345240
(5-(4-(4-aminobutylamino)pyrimidin-2-yl)benzofuran-...)Show InChI InChI=1S/C17H18N4O3/c18-6-1-2-7-19-15-5-8-20-16(21-15)11-3-4-13-12(9-11)10-14(24-13)17(22)23/h3-5,8-10H,1-2,6-7,18H2,(H,22,23)(H,19,20,21) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift method |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50345256
(5-bromo-7-(2-oxo-2-(piperazin-1-yl)ethoxy)benzofur...)Show InChI InChI=1S/C15H15BrN2O5/c16-10-5-9-6-12(15(20)21)23-14(9)11(7-10)22-8-13(19)18-3-1-17-2-4-18/h5-7,17H,1-4,8H2,(H,20,21) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift method |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50345258
(5-bromo-7-(piperidin-4-ylmethylcarbamoyl)benzofura...)Show InChI InChI=1S/C16H17BrN2O4/c17-11-5-10-6-13(16(21)22)23-14(10)12(7-11)15(20)19-8-9-1-3-18-4-2-9/h5-7,9,18H,1-4,8H2,(H,19,20)(H,21,22) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift method |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM50345240
(5-(4-(4-aminobutylamino)pyrimidin-2-yl)benzofuran-...)Show InChI InChI=1S/C17H18N4O3/c18-6-1-2-7-19-15-5-8-20-16(21-15)11-3-4-13-12(9-11)10-14(24-13)17(22)23/h3-5,8-10H,1-2,6-7,18H2,(H,22,23)(H,19,20,21) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift method |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM50345261
(CHEMBL1782532 | cis-5-bromo-7-(4-hydroxycyclohexyl...)Show SMILES O[C@H]1CC[C@H](CC1)Nc1cc(Br)cc2cc(oc12)C(O)=O |r,wU:4.7,1.0,(-2.19,-27.26,;-.86,-26.5,;-.85,-24.96,;.47,-24.19,;1.8,-24.97,;1.81,-26.5,;.47,-27.27,;3.13,-24.2,;3.13,-22.66,;1.8,-21.89,;1.8,-20.34,;.46,-19.58,;3.12,-19.57,;4.46,-20.34,;5.92,-19.85,;6.83,-21.09,;5.93,-22.35,;4.47,-21.88,;8.37,-21.09,;9.15,-22.41,;9.14,-19.75,)| Show InChI InChI=1S/C15H16BrNO4/c16-9-5-8-6-13(15(19)20)21-14(8)12(7-9)17-10-1-3-11(18)4-2-10/h5-7,10-11,17-18H,1-4H2,(H,19,20)/t10-,11+ | PDB
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B.MOAD
DrugBank
antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift method |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM50345262
(CHEMBL1782533 | trans-5-bromo-7-(4-hydroxycyclohex...)Show SMILES O[C@H]1CC[C@@H](CC1)Nc1cc(Br)cc2cc(oc12)C(O)=O |r,wU:1.0,wD:4.7,(15.29,-27.62,;16.63,-26.85,;16.63,-25.31,;17.96,-24.55,;19.28,-25.32,;19.3,-26.86,;17.96,-27.63,;20.62,-24.55,;20.61,-23.01,;19.28,-22.24,;19.28,-20.7,;17.95,-19.93,;20.61,-19.93,;21.94,-20.69,;23.41,-20.21,;24.32,-21.45,;23.42,-22.7,;21.95,-22.24,;25.86,-21.44,;26.64,-22.77,;26.62,-20.11,)| Show InChI InChI=1S/C15H16BrNO4/c16-9-5-8-6-13(15(19)20)21-14(8)12(7-9)17-10-1-3-11(18)4-2-10/h5-7,10-11,17-18H,1-4H2,(H,19,20)/t10-,11- | PDB
MMDB
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UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift method |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM50345258
(5-bromo-7-(piperidin-4-ylmethylcarbamoyl)benzofura...)Show InChI InChI=1S/C16H17BrN2O4/c17-11-5-10-6-13(16(21)22)23-14(10)12(7-11)15(20)19-8-9-1-3-18-4-2-9/h5-7,9,18H,1-4,8H2,(H,19,20)(H,21,22) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift method |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50345237
(5-(1-methyl-1H-pyrazol-4-yl)benzofuran-2-carboxyli...)Show InChI InChI=1S/C13H10N2O3/c1-15-7-10(6-14-15)8-2-3-11-9(4-8)5-12(18-11)13(16)17/h2-7H,1H3,(H,16,17) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift method |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM50345252
(5-bromo-7-(2-(pyridin-4-yl)ethoxy)benzofuran-2-car...)Show InChI InChI=1S/C16H12BrNO4/c17-12-7-11-8-14(16(19)20)22-15(11)13(9-12)21-6-3-10-1-4-18-5-2-10/h1-2,4-5,7-9H,3,6H2,(H,19,20) | PDB
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UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift method |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM50345248
(5-bromo-7-(pyridin-4-ylmethoxy)benzofuran-2-carbox...)Show InChI InChI=1S/C15H10BrNO4/c16-11-5-10-6-13(15(18)19)21-14(10)12(7-11)20-8-9-1-3-17-4-2-9/h1-7H,8H2,(H,18,19) | PDB
MMDB
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UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift method |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM50345233
(5-(trifluoromethyl)benzofuran-2-carboxylic acid | ...)Show InChI InChI=1S/C10H5F3O3/c11-10(12,13)6-1-2-7-5(3-6)4-8(16-7)9(14)15/h1-4H,(H,14,15) | PDB
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UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 5.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift method |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM50345237
(5-(1-methyl-1H-pyrazol-4-yl)benzofuran-2-carboxyli...)Show InChI InChI=1S/C13H10N2O3/c1-15-7-10(6-14-15)8-2-3-11-9(4-8)5-12(18-11)13(16)17/h2-7H,1H3,(H,16,17) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift method |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50345239
(5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)benzofuran-2...)Show InChI InChI=1S/C17H17N3O3/c21-17(22)16-8-12-7-11(1-2-15(12)23-16)13-9-19-20(10-13)14-3-5-18-6-4-14/h1-2,7-10,14,18H,3-6H2,(H,21,22) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift method |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM50345232
(5-bromo-7-methoxy-1-benzofuran-2-carboxylic acid |...)Show InChI InChI=1S/C10H7BrO4/c1-14-7-4-6(11)2-5-3-8(10(12)13)15-9(5)7/h2-4H,1H3,(H,12,13) | PDB
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| Article
PubMed
| n/a | n/a | 5.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift method |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM50345239
(5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)benzofuran-2...)Show InChI InChI=1S/C17H17N3O3/c21-17(22)16-8-12-7-11(1-2-15(12)23-16)13-9-19-20(10-13)14-3-5-18-6-4-14/h1-2,7-10,14,18H,3-6H2,(H,21,22) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 6.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift method |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50345262
(CHEMBL1782533 | trans-5-bromo-7-(4-hydroxycyclohex...)Show SMILES O[C@H]1CC[C@@H](CC1)Nc1cc(Br)cc2cc(oc12)C(O)=O |r,wU:1.0,wD:4.7,(15.29,-27.62,;16.63,-26.85,;16.63,-25.31,;17.96,-24.55,;19.28,-25.32,;19.3,-26.86,;17.96,-27.63,;20.62,-24.55,;20.61,-23.01,;19.28,-22.24,;19.28,-20.7,;17.95,-19.93,;20.61,-19.93,;21.94,-20.69,;23.41,-20.21,;24.32,-21.45,;23.42,-22.7,;21.95,-22.24,;25.86,-21.44,;26.64,-22.77,;26.62,-20.11,)| Show InChI InChI=1S/C15H16BrNO4/c16-9-5-8-6-13(15(19)20)21-14(8)12(7-9)17-10-1-3-11(18)4-2-10/h5-7,10-11,17-18H,1-4H2,(H,19,20)/t10-,11- | PDB
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UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift method |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM50345234
(5-(trifluoromethoxy)benzofuran-2-carboxylic acid |...)Show InChI InChI=1S/C10H5F3O4/c11-10(12,13)17-6-1-2-7-5(3-6)4-8(16-7)9(14)15/h1-4H,(H,14,15) | PDB
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Patents
| Article
PubMed
| n/a | n/a | 6.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift method |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50345261
(CHEMBL1782532 | cis-5-bromo-7-(4-hydroxycyclohexyl...)Show SMILES O[C@H]1CC[C@H](CC1)Nc1cc(Br)cc2cc(oc12)C(O)=O |r,wU:4.7,1.0,(-2.19,-27.26,;-.86,-26.5,;-.85,-24.96,;.47,-24.19,;1.8,-24.97,;1.81,-26.5,;.47,-27.27,;3.13,-24.2,;3.13,-22.66,;1.8,-21.89,;1.8,-20.34,;.46,-19.58,;3.12,-19.57,;4.46,-20.34,;5.92,-19.85,;6.83,-21.09,;5.93,-22.35,;4.47,-21.88,;8.37,-21.09,;9.15,-22.41,;9.14,-19.75,)| Show InChI InChI=1S/C15H16BrNO4/c16-9-5-8-6-13(15(19)20)21-14(8)12(7-9)17-10-1-3-11(18)4-2-10/h5-7,10-11,17-18H,1-4H2,(H,19,20)/t10-,11+ | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift method |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50345257
(5-bromo-7-(piperidin-4-ylcarbamoyl)benzofuran-2-ca...)Show InChI InChI=1S/C15H15BrN2O4/c16-9-5-8-6-12(15(20)21)22-13(8)11(7-9)14(19)18-10-1-3-17-4-2-10/h5-7,10,17H,1-4H2,(H,18,19)(H,20,21) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift method |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50345235
(5-(pyridin-3-yl)benzofuran-2-carboxylic acid | CHE...)Show InChI InChI=1S/C14H9NO3/c16-14(17)13-7-11-6-9(3-4-12(11)18-13)10-2-1-5-15-8-10/h1-8H,(H,16,17) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 7.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift method |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM50345236
(5-(pyrazin-2-yl)benzofuran-2-carboxylic acid | CHE...)Show InChI InChI=1S/C13H8N2O3/c16-13(17)12-6-9-5-8(1-2-11(9)18-12)10-7-14-3-4-15-10/h1-7H,(H,16,17) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 7.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift method |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM50345235
(5-(pyridin-3-yl)benzofuran-2-carboxylic acid | CHE...)Show InChI InChI=1S/C14H9NO3/c16-14(17)13-7-11-6-9(3-4-12(11)18-13)10-2-1-5-15-8-10/h1-8H,(H,16,17) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 7.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift method |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM50345231
(5-bromo-1-benzofuran-2-carboxylic acid | 5-bromobe...)Show InChI InChI=1S/C9H5BrO3/c10-6-1-2-7-5(3-6)4-8(13-7)9(11)12/h1-4H,(H,11,12) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 8.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift method |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Cytochrome P450 2C19
(Homo sapiens (Human)) | BDBM50345260
(CHEMBL1782531 | trans-7-(4-aminocyclohexylamino)-5...)Show SMILES N[C@H]1CC[C@@H](CC1)Nc1cc(Br)cc2cc(oc12)C(O)=O |r,wU:1.0,wD:4.7,(48.98,-16.4,;50.31,-15.63,;50.32,-14.09,;51.64,-13.33,;52.97,-14.1,;52.98,-15.64,;51.64,-16.4,;54.3,-13.33,;54.3,-11.79,;52.96,-11.02,;52.97,-9.48,;51.63,-8.71,;54.29,-8.71,;55.63,-9.47,;57.09,-8.99,;58,-10.23,;57.1,-11.48,;55.64,-11.01,;59.54,-10.22,;60.32,-11.55,;60.3,-8.88,)| Show InChI InChI=1S/C15H17BrN2O3/c16-9-5-8-6-13(15(19)20)21-14(8)12(7-9)18-11-3-1-10(17)2-4-11/h5-7,10-11,18H,1-4,17H2,(H,19,20)/t10-,11- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of CYP2C19 in human liver microsomes |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Cytochrome P450 3A4
(Homo sapiens (Human)) | BDBM50345260
(CHEMBL1782531 | trans-7-(4-aminocyclohexylamino)-5...)Show SMILES N[C@H]1CC[C@@H](CC1)Nc1cc(Br)cc2cc(oc12)C(O)=O |r,wU:1.0,wD:4.7,(48.98,-16.4,;50.31,-15.63,;50.32,-14.09,;51.64,-13.33,;52.97,-14.1,;52.98,-15.64,;51.64,-16.4,;54.3,-13.33,;54.3,-11.79,;52.96,-11.02,;52.97,-9.48,;51.63,-8.71,;54.29,-8.71,;55.63,-9.47,;57.09,-8.99,;58,-10.23,;57.1,-11.48,;55.64,-11.01,;59.54,-10.22,;60.32,-11.55,;60.3,-8.88,)| Show InChI InChI=1S/C15H17BrN2O3/c16-9-5-8-6-13(15(19)20)21-14(8)12(7-9)18-11-3-1-10(17)2-4-11/h5-7,10-11,18H,1-4,17H2,(H,19,20)/t10-,11- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of CYP3A4 in human liver microsomes |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Cytochrome P450 2D6
(Homo sapiens (Human)) | BDBM50345259
(CHEMBL1782530 | cis-7-(4-aminocyclohexylamino)-5-b...)Show SMILES N[C@H]1CC[C@H](CC1)Nc1cc(Br)cc2cc(oc12)C(O)=O |r,wU:4.7,1.0,(33.37,-17.22,;34.71,-16.45,;34.71,-14.91,;36.04,-14.15,;37.36,-14.92,;37.38,-16.46,;36.04,-17.22,;38.7,-14.15,;38.69,-12.61,;37.36,-11.84,;37.36,-10.3,;36.03,-9.53,;38.69,-9.53,;40.02,-10.29,;41.49,-9.81,;42.4,-11.05,;41.5,-12.3,;40.03,-11.83,;43.94,-11.04,;44.72,-12.37,;44.7,-9.7,)| Show InChI InChI=1S/C15H17BrN2O3/c16-9-5-8-6-13(15(19)20)21-14(8)12(7-9)18-11-3-1-10(17)2-4-11/h5-7,10-11,18H,1-4,17H2,(H,19,20)/t10-,11+ | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of CYP2D6 in human liver microsomes |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Cytochrome P450 2C19
(Homo sapiens (Human)) | BDBM50345259
(CHEMBL1782530 | cis-7-(4-aminocyclohexylamino)-5-b...)Show SMILES N[C@H]1CC[C@H](CC1)Nc1cc(Br)cc2cc(oc12)C(O)=O |r,wU:4.7,1.0,(33.37,-17.22,;34.71,-16.45,;34.71,-14.91,;36.04,-14.15,;37.36,-14.92,;37.38,-16.46,;36.04,-17.22,;38.7,-14.15,;38.69,-12.61,;37.36,-11.84,;37.36,-10.3,;36.03,-9.53,;38.69,-9.53,;40.02,-10.29,;41.49,-9.81,;42.4,-11.05,;41.5,-12.3,;40.03,-11.83,;43.94,-11.04,;44.72,-12.37,;44.7,-9.7,)| Show InChI InChI=1S/C15H17BrN2O3/c16-9-5-8-6-13(15(19)20)21-14(8)12(7-9)18-11-3-1-10(17)2-4-11/h5-7,10-11,18H,1-4,17H2,(H,19,20)/t10-,11+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of CYP2C19 in human liver microsomes |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Cytochrome P450 2D6
(Homo sapiens (Human)) | BDBM50345260
(CHEMBL1782531 | trans-7-(4-aminocyclohexylamino)-5...)Show SMILES N[C@H]1CC[C@@H](CC1)Nc1cc(Br)cc2cc(oc12)C(O)=O |r,wU:1.0,wD:4.7,(48.98,-16.4,;50.31,-15.63,;50.32,-14.09,;51.64,-13.33,;52.97,-14.1,;52.98,-15.64,;51.64,-16.4,;54.3,-13.33,;54.3,-11.79,;52.96,-11.02,;52.97,-9.48,;51.63,-8.71,;54.29,-8.71,;55.63,-9.47,;57.09,-8.99,;58,-10.23,;57.1,-11.48,;55.64,-11.01,;59.54,-10.22,;60.32,-11.55,;60.3,-8.88,)| Show InChI InChI=1S/C15H17BrN2O3/c16-9-5-8-6-13(15(19)20)21-14(8)12(7-9)18-11-3-1-10(17)2-4-11/h5-7,10-11,18H,1-4,17H2,(H,19,20)/t10-,11- | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of CYP2D6 in human liver microsomes |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Cytochrome P450 2D6
(Homo sapiens (Human)) | BDBM50345250
(5-bromo-7-(piperidin-4-ylmethylamino)benzofuran-2-...)Show InChI InChI=1S/C15H17BrN2O3/c16-11-5-10-6-13(15(19)20)21-14(10)12(7-11)18-8-9-1-3-17-4-2-9/h5-7,9,17-18H,1-4,8H2,(H,19,20) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of CYP2D6 in human liver microsomes |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Cytochrome P450 1A2
(Homo sapiens (Human)) | BDBM50345260
(CHEMBL1782531 | trans-7-(4-aminocyclohexylamino)-5...)Show SMILES N[C@H]1CC[C@@H](CC1)Nc1cc(Br)cc2cc(oc12)C(O)=O |r,wU:1.0,wD:4.7,(48.98,-16.4,;50.31,-15.63,;50.32,-14.09,;51.64,-13.33,;52.97,-14.1,;52.98,-15.64,;51.64,-16.4,;54.3,-13.33,;54.3,-11.79,;52.96,-11.02,;52.97,-9.48,;51.63,-8.71,;54.29,-8.71,;55.63,-9.47,;57.09,-8.99,;58,-10.23,;57.1,-11.48,;55.64,-11.01,;59.54,-10.22,;60.32,-11.55,;60.3,-8.88,)| Show InChI InChI=1S/C15H17BrN2O3/c16-9-5-8-6-13(15(19)20)21-14(8)12(7-9)18-11-3-1-10(17)2-4-11/h5-7,10-11,18H,1-4,17H2,(H,19,20)/t10-,11- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of CYP1A2 in human liver microsomes |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Cytochrome P450 1A2
(Homo sapiens (Human)) | BDBM50345250
(5-bromo-7-(piperidin-4-ylmethylamino)benzofuran-2-...)Show InChI InChI=1S/C15H17BrN2O3/c16-11-5-10-6-13(15(19)20)21-14(10)12(7-11)18-8-9-1-3-17-4-2-9/h5-7,9,17-18H,1-4,8H2,(H,19,20) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of CYP1A2 in human liver microsomes |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Cytochrome P450 1A2
(Homo sapiens (Human)) | BDBM50345259
(CHEMBL1782530 | cis-7-(4-aminocyclohexylamino)-5-b...)Show SMILES N[C@H]1CC[C@H](CC1)Nc1cc(Br)cc2cc(oc12)C(O)=O |r,wU:4.7,1.0,(33.37,-17.22,;34.71,-16.45,;34.71,-14.91,;36.04,-14.15,;37.36,-14.92,;37.38,-16.46,;36.04,-17.22,;38.7,-14.15,;38.69,-12.61,;37.36,-11.84,;37.36,-10.3,;36.03,-9.53,;38.69,-9.53,;40.02,-10.29,;41.49,-9.81,;42.4,-11.05,;41.5,-12.3,;40.03,-11.83,;43.94,-11.04,;44.72,-12.37,;44.7,-9.7,)| Show InChI InChI=1S/C15H17BrN2O3/c16-9-5-8-6-13(15(19)20)21-14(8)12(7-9)18-11-3-1-10(17)2-4-11/h5-7,10-11,18H,1-4,17H2,(H,19,20)/t10-,11+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of CYP1A2 in human liver microsomes |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Cytochrome P450 2C9
(Homo sapiens (Human)) | BDBM50345260
(CHEMBL1782531 | trans-7-(4-aminocyclohexylamino)-5...)Show SMILES N[C@H]1CC[C@@H](CC1)Nc1cc(Br)cc2cc(oc12)C(O)=O |r,wU:1.0,wD:4.7,(48.98,-16.4,;50.31,-15.63,;50.32,-14.09,;51.64,-13.33,;52.97,-14.1,;52.98,-15.64,;51.64,-16.4,;54.3,-13.33,;54.3,-11.79,;52.96,-11.02,;52.97,-9.48,;51.63,-8.71,;54.29,-8.71,;55.63,-9.47,;57.09,-8.99,;58,-10.23,;57.1,-11.48,;55.64,-11.01,;59.54,-10.22,;60.32,-11.55,;60.3,-8.88,)| Show InChI InChI=1S/C15H17BrN2O3/c16-9-5-8-6-13(15(19)20)21-14(8)12(7-9)18-11-3-1-10(17)2-4-11/h5-7,10-11,18H,1-4,17H2,(H,19,20)/t10-,11- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of CYP2C9 in human liver microsomes |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Cytochrome P450 2C9
(Homo sapiens (Human)) | BDBM50345259
(CHEMBL1782530 | cis-7-(4-aminocyclohexylamino)-5-b...)Show SMILES N[C@H]1CC[C@H](CC1)Nc1cc(Br)cc2cc(oc12)C(O)=O |r,wU:4.7,1.0,(33.37,-17.22,;34.71,-16.45,;34.71,-14.91,;36.04,-14.15,;37.36,-14.92,;37.38,-16.46,;36.04,-17.22,;38.7,-14.15,;38.69,-12.61,;37.36,-11.84,;37.36,-10.3,;36.03,-9.53,;38.69,-9.53,;40.02,-10.29,;41.49,-9.81,;42.4,-11.05,;41.5,-12.3,;40.03,-11.83,;43.94,-11.04,;44.72,-12.37,;44.7,-9.7,)| Show InChI InChI=1S/C15H17BrN2O3/c16-9-5-8-6-13(15(19)20)21-14(8)12(7-9)18-11-3-1-10(17)2-4-11/h5-7,10-11,18H,1-4,17H2,(H,19,20)/t10-,11+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of CYP2C9 in human liver microsomes |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Cytochrome P450 3A4
(Homo sapiens (Human)) | BDBM50345259
(CHEMBL1782530 | cis-7-(4-aminocyclohexylamino)-5-b...)Show SMILES N[C@H]1CC[C@H](CC1)Nc1cc(Br)cc2cc(oc12)C(O)=O |r,wU:4.7,1.0,(33.37,-17.22,;34.71,-16.45,;34.71,-14.91,;36.04,-14.15,;37.36,-14.92,;37.38,-16.46,;36.04,-17.22,;38.7,-14.15,;38.69,-12.61,;37.36,-11.84,;37.36,-10.3,;36.03,-9.53,;38.69,-9.53,;40.02,-10.29,;41.49,-9.81,;42.4,-11.05,;41.5,-12.3,;40.03,-11.83,;43.94,-11.04,;44.72,-12.37,;44.7,-9.7,)| Show InChI InChI=1S/C15H17BrN2O3/c16-9-5-8-6-13(15(19)20)21-14(8)12(7-9)18-11-3-1-10(17)2-4-11/h5-7,10-11,18H,1-4,17H2,(H,19,20)/t10-,11+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of CYP3A4 in human liver microsomes |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Cytochrome P450 2C19
(Homo sapiens (Human)) | BDBM50345250
(5-bromo-7-(piperidin-4-ylmethylamino)benzofuran-2-...)Show InChI InChI=1S/C15H17BrN2O3/c16-11-5-10-6-13(15(19)20)21-14(10)12(7-11)18-8-9-1-3-17-4-2-9/h5-7,9,17-18H,1-4,8H2,(H,19,20) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of CYP2C19 in human liver microsomes |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Cytochrome P450 3A4
(Homo sapiens (Human)) | BDBM50345250
(5-bromo-7-(piperidin-4-ylmethylamino)benzofuran-2-...)Show InChI InChI=1S/C15H17BrN2O3/c16-11-5-10-6-13(15(19)20)21-14(10)12(7-11)18-8-9-1-3-17-4-2-9/h5-7,9,17-18H,1-4,8H2,(H,19,20) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of CYP3A4 in human liver microsomes |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Cytochrome P450 2C9
(Homo sapiens (Human)) | BDBM50345250
(5-bromo-7-(piperidin-4-ylmethylamino)benzofuran-2-...)Show InChI InChI=1S/C15H17BrN2O3/c16-11-5-10-6-13(15(19)20)21-14(10)12(7-11)18-8-9-1-3-17-4-2-9/h5-7,9,17-18H,1-4,8H2,(H,19,20) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of CYP2C9 in human liver microsomes |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50345236
(5-(pyrazin-2-yl)benzofuran-2-carboxylic acid | CHE...)Show InChI InChI=1S/C13H8N2O3/c16-13(17)12-6-9-5-8(1-2-11(9)18-12)10-7-14-3-4-15-10/h1-7H,(H,16,17) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.19E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift method |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50345248
(5-bromo-7-(pyridin-4-ylmethoxy)benzofuran-2-carbox...)Show InChI InChI=1S/C15H10BrNO4/c16-11-5-10-6-13(15(18)19)21-14(10)12(7-11)20-8-9-1-3-17-4-2-9/h1-7H,8H2,(H,18,19) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.25E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift method |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50345233
(5-(trifluoromethyl)benzofuran-2-carboxylic acid | ...)Show InChI InChI=1S/C10H5F3O3/c11-10(12,13)6-1-2-7-5(3-6)4-8(16-7)9(14)15/h1-4H,(H,14,15) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 1.35E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift method |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50345252
(5-bromo-7-(2-(pyridin-4-yl)ethoxy)benzofuran-2-car...)Show InChI InChI=1S/C16H12BrNO4/c17-12-7-11-8-14(16(19)20)22-15(11)13(9-12)21-6-3-10-1-4-18-5-2-10/h1-2,4-5,7-9H,3,6H2,(H,19,20) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.11E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift method |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM50345230
(1-benzofuran-2-carboxylic acid | CHEMBL84095 | ben...)Show InChI InChI=1S/C9H6O3/c10-9(11)8-5-6-3-1-2-4-7(6)12-8/h1-5H,(H,10,11) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.19E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp.
Curated by ChEMBL
| Assay Description
Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift method |
Bioorg Med Chem Lett 21: 3050-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG |
More data for this
Ligand-Target Pair | |
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