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PubMed code 21524581

Compile data set for download or QSAR
Found 105 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))		BDBM50344294
PNG
((R)-1-(2-phenoxyethyl)-3-(phenyl(thiophen-3-ylmeth...)
Show SMILES O=C(O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)N(Cc1ccsc1)c1ccccc1 |r,wD:3.2,(.53,-12.66,;.53,-14.2,;1.87,-14.97,;3.2,-14.2,;4.53,-14.98,;5.86,-14.22,;7.19,-14.98,;8.52,-14.21,;9.85,-14.98,;11.19,-14.21,;12.51,-14.98,;13.85,-14.21,;13.85,-12.67,;12.5,-11.9,;11.18,-12.68,;5.87,-12.68,;4.54,-11.9,;3.19,-12.67,;3.95,-13.99,;5.08,-12.87,;-.8,-14.97,;-.8,-16.51,;-2.13,-17.28,;-3.54,-16.66,;-4.57,-17.8,;-3.8,-19.14,;-2.29,-18.82,;-2.13,-14.2,;-2.13,-12.66,;-3.46,-11.89,;-4.79,-12.66,;-4.79,-14.21,;-3.46,-14.97,)|
Show InChI InChI=1S/C27H31N2O3S/c30-27(28(19-22-13-18-33-21-22)24-7-3-1-4-8-24)32-26-20-29(14-11-23(26)12-15-29)16-17-31-25-9-5-2-6-10-25/h1-10,13,18,21,23,26H,11-12,14-17,19-20H2/q+1/t23?,26-,29?/m0/s1
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n/an/a 0.200n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))		BDBM50344287
PNG
((R)-3-(benzyl(phenyl)carbamoyloxy)-1-(3-phenylprop...)
Show SMILES O=C(O[C@H]1C[N+]2(CCCc3ccccc3)CCC1CC2)N(Cc1ccccc1)c1ccccc1 |r,wD:3.2,(20.32,-12.49,;20.32,-14.03,;21.65,-14.8,;22.99,-14.03,;24.32,-14.81,;25.65,-14.04,;26.97,-14.81,;28.31,-14.04,;29.64,-14.81,;30.97,-14.04,;32.3,-14.81,;33.63,-14.04,;33.63,-12.5,;32.29,-11.73,;30.96,-12.5,;25.66,-12.5,;24.32,-11.73,;22.98,-12.5,;23.74,-13.82,;24.87,-12.7,;18.99,-14.8,;18.99,-16.34,;17.65,-17.11,;16.32,-16.33,;14.99,-17.1,;14.99,-18.64,;16.33,-19.41,;17.66,-18.64,;17.65,-14.03,;17.66,-12.49,;16.33,-11.72,;14.99,-12.49,;15,-14.04,;16.33,-14.8,)|
Show InChI InChI=1S/C30H35N2O2/c33-30(31(28-16-8-3-9-17-28)23-26-13-6-2-7-14-26)34-29-24-32(21-18-27(29)19-22-32)20-10-15-25-11-4-1-5-12-25/h1-9,11-14,16-17,27,29H,10,15,18-24H2/q+1/t27?,29-,32?/m0/s1
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n/an/a 0.300n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))		BDBM50344292
PNG
((R)-1-(2-phenoxyethyl)-3-(phenyl(thiophen-2-ylmeth...)
Show SMILES O=C(O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)N(Cc1cccs1)c1ccccc1 |r,wD:3.2,(-.81,1.63,;-.81,.09,;.52,-.68,;1.85,.09,;3.19,-.68,;4.52,.08,;5.84,-.68,;7.17,.09,;8.51,-.68,;9.84,.09,;11.17,-.69,;12.5,.08,;12.5,1.63,;11.16,2.39,;9.83,1.62,;4.52,1.62,;3.19,2.39,;1.85,1.63,;2.61,.3,;3.73,1.42,;-2.15,-.68,;-2.15,-2.22,;-3.48,-2.99,;-4.89,-2.37,;-5.92,-3.51,;-5.15,-4.84,;-3.65,-4.52,;-3.48,.09,;-3.47,1.64,;-4.8,2.41,;-6.14,1.64,;-6.13,.09,;-4.8,-.68,)|
Show InChI InChI=1S/C27H31N2O3S/c30-27(28(20-25-12-7-19-33-25)23-8-3-1-4-9-23)32-26-21-29(15-13-22(26)14-16-29)17-18-31-24-10-5-2-6-11-24/h1-12,19,22,26H,13-18,20-21H2/q+1/t22?,26-,29?/m0/s1
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n/an/a 0.300n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50344292
PNG
((R)-1-(2-phenoxyethyl)-3-(phenyl(thiophen-2-ylmeth...)
Show SMILES O=C(O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)N(Cc1cccs1)c1ccccc1 |r,wD:3.2,(-.81,1.63,;-.81,.09,;.52,-.68,;1.85,.09,;3.19,-.68,;4.52,.08,;5.84,-.68,;7.17,.09,;8.51,-.68,;9.84,.09,;11.17,-.69,;12.5,.08,;12.5,1.63,;11.16,2.39,;9.83,1.62,;4.52,1.62,;3.19,2.39,;1.85,1.63,;2.61,.3,;3.73,1.42,;-2.15,-.68,;-2.15,-2.22,;-3.48,-2.99,;-4.89,-2.37,;-5.92,-3.51,;-5.15,-4.84,;-3.65,-4.52,;-3.48,.09,;-3.47,1.64,;-4.8,2.41,;-6.14,1.64,;-6.13,.09,;-4.8,-.68,)|
Show InChI InChI=1S/C27H31N2O3S/c30-27(28(20-25-12-7-19-33-25)23-8-3-1-4-9-23)32-26-21-29(15-13-22(26)14-16-29)17-18-31-24-10-5-2-6-11-24/h1-12,19,22,26H,13-18,20-21H2/q+1/t22?,26-,29?/m0/s1
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n/an/a 0.400n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50344303
PNG
((R)-quinuclidin-3-yl benzyl(phenyl)carbamate | CHE...)
Show SMILES O=C(O[C@H]1CN2CCC1CC2)N(Cc1ccccc1)c1ccccc1 |r,wD:3.2,(10.51,3.48,;10.51,1.94,;11.85,1.17,;13.18,1.94,;14.51,1.17,;15.84,1.93,;15.85,3.47,;14.51,4.25,;13.17,3.48,;13.93,2.15,;15.06,3.27,;9.18,1.17,;9.18,-.37,;7.84,-1.14,;6.51,-.36,;5.18,-1.13,;5.18,-2.67,;6.52,-3.44,;7.85,-2.66,;7.84,1.94,;7.85,3.49,;6.52,4.26,;5.19,3.49,;5.19,1.94,;6.52,1.18,)|
Show InChI InChI=1S/C21H24N2O2/c24-21(25-20-16-22-13-11-18(20)12-14-22)23(19-9-5-2-6-10-19)15-17-7-3-1-4-8-17/h1-10,18,20H,11-16H2/t20-/m0/s1
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n/an/a 0.400n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50344271
PNG
((R)-quinuclidin-3-yl phenyl(thiophen-3-ylmethyl)ca...)
Show SMILES O=C(O[C@H]1CN2CCC1CC2)N(Cc1ccsc1)c1ccccc1 |r,wD:3.2,(10.43,-7.93,;10.43,-9.47,;11.77,-10.24,;13.1,-9.47,;14.43,-10.25,;15.76,-9.49,;15.77,-7.95,;14.44,-7.17,;13.1,-7.94,;13.85,-9.26,;14.98,-8.14,;9.1,-10.24,;9.1,-11.78,;7.77,-12.55,;6.36,-11.94,;5.33,-13.08,;6.1,-14.41,;7.61,-14.09,;7.77,-9.47,;7.78,-7.93,;6.44,-7.16,;5.11,-7.93,;5.11,-9.48,;6.45,-10.24,)|
Show InChI InChI=1S/C19H22N2O2S/c22-19(23-18-13-20-9-6-16(18)7-10-20)21(12-15-8-11-24-14-15)17-4-2-1-3-5-17/h1-5,8,11,14,16,18H,6-7,9-10,12-13H2/t18-/m0/s1
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n/an/a 0.400n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50344270
PNG
((R)-quinuclidin-3-yl phenyl(thiophen-2-ylmethyl)ca...)
Show SMILES O=C(O[C@H]1CN2CCC1CC2)N(Cc1cccs1)c1ccccc1 |r,wD:3.2,(-3.52,-8.18,;-3.52,-9.72,;-2.19,-10.49,;-.85,-9.72,;.48,-10.5,;1.81,-9.74,;1.82,-8.2,;.48,-7.42,;-.86,-8.19,;-.1,-9.51,;1.03,-8.39,;-4.85,-10.49,;-4.85,-12.03,;-6.19,-12.8,;-7.6,-12.18,;-8.63,-13.33,;-7.86,-14.66,;-6.36,-14.34,;-6.19,-9.72,;-6.19,-8.18,;-7.52,-7.41,;-8.85,-8.18,;-8.85,-9.73,;-7.52,-10.49,)|
Show InChI InChI=1S/C19H22N2O2S/c22-19(23-18-14-20-10-8-15(18)9-11-20)21(13-17-7-4-12-24-17)16-5-2-1-3-6-16/h1-7,12,15,18H,8-11,13-14H2/t18-/m0/s1
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n/an/a 0.400n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50344294
PNG
((R)-1-(2-phenoxyethyl)-3-(phenyl(thiophen-3-ylmeth...)
Show SMILES O=C(O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)N(Cc1ccsc1)c1ccccc1 |r,wD:3.2,(.53,-12.66,;.53,-14.2,;1.87,-14.97,;3.2,-14.2,;4.53,-14.98,;5.86,-14.22,;7.19,-14.98,;8.52,-14.21,;9.85,-14.98,;11.19,-14.21,;12.51,-14.98,;13.85,-14.21,;13.85,-12.67,;12.5,-11.9,;11.18,-12.68,;5.87,-12.68,;4.54,-11.9,;3.19,-12.67,;3.95,-13.99,;5.08,-12.87,;-.8,-14.97,;-.8,-16.51,;-2.13,-17.28,;-3.54,-16.66,;-4.57,-17.8,;-3.8,-19.14,;-2.29,-18.82,;-2.13,-14.2,;-2.13,-12.66,;-3.46,-11.89,;-4.79,-12.66,;-4.79,-14.21,;-3.46,-14.97,)|
Show InChI InChI=1S/C27H31N2O3S/c30-27(28(19-22-13-18-33-21-22)24-7-3-1-4-8-24)32-26-20-29(14-11-23(26)12-15-29)16-17-31-25-9-5-2-6-10-25/h1-10,13,18,21,23,26H,11-12,14-17,19-20H2/q+1/t23?,26-,29?/m0/s1
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n/an/a 0.400n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))		BDBM50344291
PNG
((R)-3-(phenyl(thiophen-2-ylmethyl)carbamoyloxy)-1-...)
Show SMILES O=C(O[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)N(Cc1cccs1)c1ccccc1 |r,wD:3.2,(21.03,-39.07,;21.03,-40.61,;22.36,-41.38,;23.69,-40.61,;25.03,-41.38,;26.36,-40.62,;27.68,-41.39,;29.01,-40.61,;30.35,-41.38,;31.68,-40.61,;31.84,-39.07,;33.35,-38.75,;34.12,-40.09,;33.09,-41.23,;26.36,-39.08,;25.03,-38.31,;23.69,-39.07,;24.45,-40.4,;25.57,-39.28,;19.69,-41.38,;19.69,-42.92,;18.36,-43.69,;16.95,-43.07,;15.92,-44.21,;16.69,-45.55,;18.19,-45.23,;18.36,-40.61,;18.37,-39.07,;17.04,-38.3,;15.7,-39.07,;15.71,-40.61,;17.04,-41.38,)|
Show InChI InChI=1S/C26H31N2O2S2/c29-26(27(19-24-11-6-18-32-24)22-7-2-1-3-8-22)30-25-20-28(15-12-21(25)13-16-28)14-4-9-23-10-5-17-31-23/h1-3,5-8,10-11,17-18,21,25H,4,9,12-16,19-20H2/q+1/t21?,25-,28?/m0/s1
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n/an/a 0.5n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))		BDBM50344293
PNG
((R)-3-(phenyl(thiophen-3-ylmethyl)carbamoyloxy)-1-...)
Show SMILES O=C(O[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)N(Cc1ccsc1)c1ccccc1 |r,wD:3.2,(21.62,.98,;21.62,-.56,;22.95,-1.33,;24.29,-.56,;25.62,-1.34,;26.95,-.57,;28.27,-1.34,;29.61,-.57,;30.94,-1.34,;32.27,-.57,;32.43,.97,;33.93,1.29,;34.71,-.05,;33.68,-1.19,;26.95,.97,;25.62,1.74,;24.28,.97,;25.04,-.35,;26.16,.77,;20.28,-1.33,;20.28,-2.87,;18.95,-3.64,;17.55,-3.02,;16.52,-4.16,;17.29,-5.49,;18.79,-5.17,;18.95,-.56,;18.96,.98,;17.63,1.75,;16.29,.98,;16.3,-.57,;17.63,-1.33,)|
Show InChI InChI=1S/C26H31N2O2S2/c29-26(27(18-21-12-17-31-20-21)23-6-2-1-3-7-23)30-25-19-28(14-10-22(25)11-15-28)13-4-8-24-9-5-16-32-24/h1-3,5-7,9,12,16-17,20,22,25H,4,8,10-11,13-15,18-19H2/q+1/t22?,25-,28?/m0/s1
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n/an/a 0.600n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))		BDBM50344288
PNG
((R)-3-(benzyl(phenyl)carbamoyloxy)-1-(3-(thiophen-...)
Show SMILES O=C(O[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)N(Cc1ccccc1)c1ccccc1 |r,wD:3.2,(.46,-25.61,;.46,-27.15,;1.8,-27.92,;3.13,-27.15,;4.46,-27.93,;5.79,-27.17,;7.12,-27.93,;8.45,-27.16,;9.78,-27.93,;11.12,-27.16,;11.28,-25.62,;12.78,-25.3,;13.55,-26.63,;12.52,-27.78,;5.8,-25.63,;4.47,-24.85,;3.12,-25.62,;3.88,-26.94,;5.01,-25.82,;-.87,-27.92,;-.87,-29.46,;-2.2,-30.23,;-3.54,-29.45,;-4.87,-30.22,;-4.87,-31.76,;-3.53,-32.53,;-2.2,-31.76,;-2.2,-27.15,;-2.2,-25.61,;-3.53,-24.84,;-4.86,-25.61,;-4.86,-27.16,;-3.53,-27.92,)|
Show InChI InChI=1S/C28H33N2O2S/c31-28(29(25-11-5-2-6-12-25)21-23-9-3-1-4-10-23)32-27-22-30(18-15-24(27)16-19-30)17-7-13-26-14-8-20-33-26/h1-6,8-12,14,20,24,27H,7,13,15-19,21-22H2/q+1/t24?,27-,30?/m0/s1
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n/an/a 0.600n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))		BDBM50344297
PNG
((R)-3-(butyl(phenyl)carbamoyloxy)-1-(3-(thiophen-2...)
Show SMILES CCCCN(C(=O)O[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)c1ccccc1 |r,wD:8.7,(18.41,-29.52,;19.75,-28.75,;21.08,-29.52,;22.42,-28.75,;22.42,-27.21,;23.75,-26.44,;23.75,-24.9,;25.08,-27.21,;26.42,-26.44,;27.75,-27.21,;29.08,-26.45,;30.4,-27.21,;31.74,-26.44,;33.07,-27.21,;34.4,-26.44,;34.56,-24.9,;36.07,-24.58,;36.84,-25.91,;35.81,-27.06,;29.09,-24.91,;27.75,-24.14,;26.41,-24.9,;27.17,-26.23,;28.3,-25.11,;21.08,-26.44,;21.09,-24.89,;19.76,-24.12,;18.42,-24.89,;18.43,-26.44,;19.76,-27.21,)|
Show InChI InChI=1S/C25H35N2O2S/c1-2-3-15-26(22-9-5-4-6-10-22)25(28)29-24-20-27(17-13-21(24)14-18-27)16-7-11-23-12-8-19-30-23/h4-6,8-10,12,19,21,24H,2-3,7,11,13-18,20H2,1H3/q+1/t21?,24-,27?/m0/s1
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n/an/a 0.600n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))		BDBM50344270
PNG
((R)-quinuclidin-3-yl phenyl(thiophen-2-ylmethyl)ca...)
Show SMILES O=C(O[C@H]1CN2CCC1CC2)N(Cc1cccs1)c1ccccc1 |r,wD:3.2,(-3.52,-8.18,;-3.52,-9.72,;-2.19,-10.49,;-.85,-9.72,;.48,-10.5,;1.81,-9.74,;1.82,-8.2,;.48,-7.42,;-.86,-8.19,;-.1,-9.51,;1.03,-8.39,;-4.85,-10.49,;-4.85,-12.03,;-6.19,-12.8,;-7.6,-12.18,;-8.63,-13.33,;-7.86,-14.66,;-6.36,-14.34,;-6.19,-9.72,;-6.19,-8.18,;-7.52,-7.41,;-8.85,-8.18,;-8.85,-9.73,;-7.52,-10.49,)|
Show InChI InChI=1S/C19H22N2O2S/c22-19(23-18-14-20-10-8-15(18)9-11-20)21(13-17-7-4-12-24-17)16-5-2-1-3-6-16/h1-7,12,15,18H,8-11,13-14H2/t18-/m0/s1
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n/an/a 0.600n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))		BDBM50344301
PNG
((R)-3-((3-fluorophenyl)(3,4,5-trifluorobenzyl)carb...)
Show SMILES Fc1cccc(c1)N(Cc1cc(F)c(F)c(F)c1)C(=O)O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2 |r,wD:21.22,(-3.92,-9.63,;-3.92,-11.17,;-5.25,-11.94,;-5.25,-13.49,;-3.91,-14.25,;-2.59,-13.48,;-2.58,-11.94,;-1.26,-14.25,;-1.26,-15.79,;-2.59,-16.56,;-3.92,-15.78,;-5.26,-16.55,;-6.59,-15.78,;-5.26,-18.09,;-6.59,-18.86,;-3.91,-18.86,;-3.91,-20.4,;-2.59,-18.09,;.07,-13.48,;.07,-11.94,;1.41,-14.25,;2.74,-13.48,;4.07,-14.26,;5.4,-13.49,;6.73,-14.26,;8.06,-13.49,;9.4,-14.25,;10.73,-13.48,;12.06,-14.26,;13.39,-13.49,;13.39,-11.95,;12.04,-11.18,;10.72,-11.95,;5.41,-11.95,;4.08,-11.18,;2.74,-11.94,;3.49,-13.27,;4.62,-12.15,)|
Show InChI InChI=1S/C29H29F4N2O3/c30-22-5-4-6-23(17-22)34(18-20-15-25(31)28(33)26(32)16-20)29(36)38-27-19-35(11-9-21(27)10-12-35)13-14-37-24-7-2-1-3-8-24/h1-8,15-17,21,27H,9-14,18-19H2/q+1/t21?,27-,35?/m0/s1
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n/an/a 0.600n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))		BDBM50344296
PNG
((R)-3-(butyl(phenyl)carbamoyloxy)-1-(3-phenylpropy...)
Show SMILES CCCCN(C(=O)O[C@H]1C[N+]2(CCCc3ccccc3)CCC1CC2)c1ccccc1 |r,wD:8.7,(-3.06,-29.35,;-1.73,-28.58,;-.39,-29.35,;.94,-28.58,;.94,-27.04,;2.27,-26.27,;2.27,-24.73,;3.61,-27.04,;4.94,-26.27,;6.27,-27.05,;7.6,-26.29,;8.93,-27.05,;10.26,-26.28,;11.6,-27.05,;12.93,-26.28,;14.26,-27.05,;15.59,-26.28,;15.59,-24.74,;14.25,-23.97,;12.92,-24.75,;7.61,-24.75,;6.28,-23.97,;4.94,-24.74,;5.69,-26.06,;6.82,-24.94,;-.39,-26.27,;-.38,-24.73,;-1.72,-23.96,;-3.05,-24.73,;-3.05,-26.28,;-1.71,-27.04,)|
Show InChI InChI=1S/C27H37N2O2/c1-2-3-18-28(25-14-8-5-9-15-25)27(30)31-26-22-29(20-16-24(26)17-21-29)19-10-13-23-11-6-4-7-12-23/h4-9,11-12,14-15,24,26H,2-3,10,13,16-22H2,1H3/q+1/t24?,26-,29?/m0/s1
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n/an/a 0.800n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50344274
PNG
((R)-quinuclidin-3-yl pentyl(phenyl)carbamate | CHE...)
Show SMILES CCCCCN(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1 |r,wD:9.8,(12.29,-26.84,;12.29,-25.3,;10.95,-24.53,;10.95,-22.99,;9.62,-22.22,;9.62,-20.68,;10.95,-19.91,;10.95,-18.37,;12.29,-20.68,;13.62,-19.91,;14.95,-20.69,;16.28,-19.92,;16.29,-18.38,;14.96,-17.61,;13.62,-18.38,;14.37,-19.7,;15.5,-18.58,;8.29,-19.91,;8.3,-18.37,;6.96,-17.6,;5.63,-18.37,;5.63,-19.92,;6.97,-20.68,)|
Show InChI InChI=1S/C19H28N2O2/c1-2-3-7-12-21(17-8-5-4-6-9-17)19(22)23-18-15-20-13-10-16(18)11-14-20/h4-6,8-9,16,18H,2-3,7,10-15H2,1H3/t18-/m0/s1
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n/an/a 0.800n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50344278
PNG
((R)-quinuclidin-3-yl butyl(thiophen-2-ylmethyl)car...)
Show SMILES CCCCN(Cc1cccs1)C(=O)O[C@H]1CN2CCC1CC2 |r,wD:14.14,(21.3,-35.16,;22.63,-34.39,;23.97,-35.16,;25.3,-34.39,;25.3,-32.85,;23.97,-32.08,;23.97,-30.54,;25.2,-29.63,;24.73,-28.16,;23.19,-28.16,;22.71,-29.63,;26.63,-32.08,;26.63,-30.54,;27.97,-32.85,;29.3,-32.08,;30.63,-32.85,;31.96,-32.09,;31.97,-30.55,;30.64,-29.77,;29.3,-30.54,;30.05,-31.87,;31.18,-30.75,)|
Show InChI InChI=1S/C17H26N2O2S/c1-2-3-8-19(12-15-5-4-11-22-15)17(20)21-16-13-18-9-6-14(16)7-10-18/h4-5,11,14,16H,2-3,6-10,12-13H2,1H3/t16-/m0/s1
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n/an/a 0.800n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))		BDBM50344298
PNG
((R)-3-(butyl(phenyl)carbamoyloxy)-1-(2-phenoxyethy...)
Show SMILES CCCCN(C(=O)O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)c1ccccc1 |r,wD:8.7,(-5.8,-41.35,;-4.46,-40.58,;-3.13,-41.35,;-1.8,-40.58,;-1.8,-39.04,;-.46,-38.27,;-.46,-36.73,;.87,-39.04,;2.2,-38.27,;3.54,-39.05,;4.87,-38.29,;6.19,-39.05,;7.52,-38.28,;8.86,-39.05,;10.19,-38.28,;11.52,-39.05,;12.85,-38.28,;12.85,-36.74,;11.51,-35.97,;10.18,-36.75,;4.87,-36.75,;3.54,-35.97,;2.2,-36.74,;2.96,-38.06,;4.08,-36.94,;-3.13,-38.27,;-3.12,-36.73,;-4.45,-35.96,;-5.79,-36.73,;-5.78,-38.28,;-4.45,-39.04,)|
Show InChI InChI=1S/C26H35N2O3/c1-2-3-16-27(23-10-6-4-7-11-23)26(29)31-25-21-28(17-14-22(25)15-18-28)19-20-30-24-12-8-5-9-13-24/h4-13,22,25H,2-3,14-21H2,1H3/q+1/t22?,25-,28?/m0/s1
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n/an/a 0.800n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50344283
PNG
((R)-quinuclidin-3-yl 3-fluorophenyl(3,4,5-trifluor...)
Show SMILES Fc1cccc(c1)N(Cc1cc(F)c(F)c(F)c1)C(=O)O[C@H]1CN2CCC1CC2 |r,wD:21.22,(13.85,4.33,;13.85,2.79,;12.51,2.02,;12.52,.47,;13.85,-.29,;15.18,.47,;15.18,2.02,;16.51,-.3,;16.51,-1.84,;15.18,-2.61,;13.84,-1.83,;12.51,-2.6,;11.18,-1.83,;12.51,-4.14,;11.18,-4.92,;13.85,-4.91,;13.86,-6.45,;15.18,-4.14,;17.85,.47,;17.85,2.01,;19.18,-.3,;20.51,.47,;21.84,-.3,;23.17,.46,;23.18,2,;21.85,2.78,;20.51,2.01,;21.26,.68,;22.39,1.8,)|
Show InChI InChI=1S/C21H20F4N2O2/c22-15-2-1-3-16(10-15)27(11-13-8-17(23)20(25)18(24)9-13)21(28)29-19-12-26-6-4-14(19)5-7-26/h1-3,8-10,14,19H,4-7,11-12H2/t19-/m0/s1
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n/an/a 0.900n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))		BDBM50344299
PNG
((R)-1-(3-phenylpropyl)-3-(m-tolyl(2,4,5-trifluorob...)
Show SMILES Cc1cccc(c1)N(Cc1cc(F)c(F)cc1F)C(=O)O[C@H]1C[N+]2(CCCc3ccccc3)CCC1CC2 |r,wD:21.22,(-4.97,4.35,;-4.97,2.81,;-6.31,2.04,;-6.3,.49,;-4.97,-.27,;-3.65,.5,;-3.64,2.04,;-2.32,-.27,;-2.32,-1.81,;-3.65,-2.58,;-4.98,-1.8,;-6.31,-2.57,;-7.65,-1.8,;-6.32,-4.11,;-7.65,-4.89,;-4.97,-4.88,;-3.65,-4.11,;-2.31,-4.87,;-.98,.5,;-.98,2.04,;.35,-.27,;1.68,.5,;3.01,-.28,;4.34,.48,;5.67,-.28,;7,.49,;8.34,-.28,;9.67,.49,;11,-.28,;12.33,.49,;12.33,2.03,;10.99,2.8,;9.66,2.02,;4.35,2.02,;3.02,2.8,;1.68,2.03,;2.43,.71,;3.56,1.83,)|
Show InChI InChI=1S/C31H34F3N2O2/c1-22-7-5-11-26(17-22)35(20-25-18-28(33)29(34)19-27(25)32)31(37)38-30-21-36(15-12-24(30)13-16-36)14-6-10-23-8-3-2-4-9-23/h2-5,7-9,11,17-19,24,30H,6,10,12-16,20-21H2,1H3/q+1/t24?,30-,36?/m0/s1
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n/an/a 0.900n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))		BDBM50344271
PNG
((R)-quinuclidin-3-yl phenyl(thiophen-3-ylmethyl)ca...)
Show SMILES O=C(O[C@H]1CN2CCC1CC2)N(Cc1ccsc1)c1ccccc1 |r,wD:3.2,(10.43,-7.93,;10.43,-9.47,;11.77,-10.24,;13.1,-9.47,;14.43,-10.25,;15.76,-9.49,;15.77,-7.95,;14.44,-7.17,;13.1,-7.94,;13.85,-9.26,;14.98,-8.14,;9.1,-10.24,;9.1,-11.78,;7.77,-12.55,;6.36,-11.94,;5.33,-13.08,;6.1,-14.41,;7.61,-14.09,;7.77,-9.47,;7.78,-7.93,;6.44,-7.16,;5.11,-7.93,;5.11,-9.48,;6.45,-10.24,)|
Show InChI InChI=1S/C19H22N2O2S/c22-19(23-18-13-20-9-6-16(18)7-10-20)21(12-15-8-11-24-14-15)17-4-2-1-3-5-17/h1-5,8,11,14,16,18H,6-7,9-10,12-13H2/t18-/m0/s1
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n/an/a 1n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50344282
PNG
((R)-quinuclidin-3-yl m-tolyl(2,4,5-trifluorobenzyl...)
Show SMILES Cc1cccc(c1)N(Cc1cc(F)c(F)cc1F)C(=O)O[C@H]1CN2CCC1CC2 |r,wD:21.22,(-3.76,3.63,;-3.76,2.09,;-5.1,1.32,;-5.09,-.22,;-3.76,-.99,;-2.43,-.22,;-2.43,1.32,;-1.1,-.99,;-1.1,-2.53,;-2.43,-3.3,;-3.77,-2.53,;-5.1,-3.29,;-6.43,-2.52,;-5.1,-4.84,;-6.43,-5.61,;-3.76,-5.61,;-2.43,-4.83,;-1.09,-5.6,;.24,-.22,;.24,1.32,;1.57,-.99,;2.9,-.22,;4.24,-.99,;5.57,-.23,;5.57,1.31,;4.24,2.08,;2.9,1.32,;3.66,-.01,;4.78,1.11,)|
Show InChI InChI=1S/C22H23F3N2O2/c1-14-3-2-4-17(9-14)27(12-16-10-19(24)20(25)11-18(16)23)22(28)29-21-13-26-7-5-15(21)6-8-26/h2-4,9-11,15,21H,5-8,12-13H2,1H3/t21-/m0/s1
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n/an/a 1n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50344269
PNG
((R)-quinuclidin-3-yl phenethyl(phenyl)carbamate | ...)
Show SMILES O=C(O[C@H]1CN2CCC1CC2)N(CCc1ccccc1)c1ccccc1 |r,wD:3.2,(25.48,4.31,;25.48,2.77,;26.82,2,;28.15,2.77,;29.48,1.99,;30.81,2.76,;30.82,4.3,;29.49,5.07,;28.15,4.3,;28.9,2.98,;30.03,4.1,;24.15,2,;24.15,.46,;22.82,-.31,;22.82,-1.85,;21.48,-2.61,;21.48,-4.15,;22.81,-4.92,;24.15,-4.15,;24.14,-2.61,;22.82,2.77,;22.83,4.31,;21.49,5.08,;20.16,4.31,;20.16,2.76,;21.5,2,)|
Show InChI InChI=1S/C22H26N2O2/c25-22(26-21-17-23-14-12-19(21)13-15-23)24(20-9-5-2-6-10-20)16-11-18-7-3-1-4-8-18/h1-10,19,21H,11-17H2/t21-/m0/s1
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n/an/a 1n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))		BDBM50344289
PNG
((R)-3-(benzyl(phenyl)carbamoyloxy)-1-(2-phenoxyeth...)
Show SMILES O=C(O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)N(Cc1ccccc1)c1ccccc1 |r,wD:3.2,(22.07,-23.51,;22.07,-25.05,;23.4,-25.82,;24.74,-25.05,;26.07,-25.83,;27.4,-25.07,;28.72,-25.83,;30.06,-25.06,;31.39,-25.83,;32.72,-25.06,;34.05,-25.83,;35.38,-25.06,;35.38,-23.52,;34.04,-22.75,;32.71,-23.53,;27.41,-23.53,;26.07,-22.75,;24.73,-23.52,;25.49,-24.84,;26.62,-23.72,;20.74,-25.82,;20.74,-27.36,;19.4,-28.13,;18.07,-27.35,;16.74,-28.12,;16.74,-29.66,;18.08,-30.43,;19.41,-29.66,;19.4,-25.05,;19.41,-23.51,;18.08,-22.74,;16.74,-23.51,;16.75,-25.06,;18.08,-25.82,)|
Show InChI InChI=1S/C29H33N2O3/c32-29(30(26-12-6-2-7-13-26)22-24-10-4-1-5-11-24)34-28-23-31(18-16-25(28)17-19-31)20-21-33-27-14-8-3-9-15-27/h1-15,25,28H,16-23H2/q+1/t25?,28-,31?/m0/s1
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n/an/a 1n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50344273
PNG
((R)-quinuclidin-3-yl butyl(phenyl)carbamate | CHEM...)
Show SMILES CCCCN(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1 |r,wD:8.7,(-8.01,-25.61,;-6.68,-24.84,;-6.68,-23.3,;-5.34,-22.53,;-5.34,-20.99,;-4.01,-20.22,;-4.01,-18.68,;-2.68,-20.99,;-1.34,-20.22,;-.01,-21,;1.32,-20.24,;1.33,-18.7,;-.01,-17.92,;-1.35,-18.69,;-.59,-20.01,;.54,-18.89,;-6.68,-20.22,;-6.67,-18.68,;-8,-17.91,;-9.34,-18.68,;-9.33,-20.23,;-8,-20.99,)|
Show InChI InChI=1S/C18H26N2O2/c1-2-3-11-20(16-7-5-4-6-8-16)18(21)22-17-14-19-12-9-15(17)10-13-19/h4-8,15,17H,2-3,9-14H2,1H3/t17-/m0/s1
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n/an/a 1.10n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50344301
PNG
((R)-3-((3-fluorophenyl)(3,4,5-trifluorobenzyl)carb...)
Show SMILES Fc1cccc(c1)N(Cc1cc(F)c(F)c(F)c1)C(=O)O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2 |r,wD:21.22,(-3.92,-9.63,;-3.92,-11.17,;-5.25,-11.94,;-5.25,-13.49,;-3.91,-14.25,;-2.59,-13.48,;-2.58,-11.94,;-1.26,-14.25,;-1.26,-15.79,;-2.59,-16.56,;-3.92,-15.78,;-5.26,-16.55,;-6.59,-15.78,;-5.26,-18.09,;-6.59,-18.86,;-3.91,-18.86,;-3.91,-20.4,;-2.59,-18.09,;.07,-13.48,;.07,-11.94,;1.41,-14.25,;2.74,-13.48,;4.07,-14.26,;5.4,-13.49,;6.73,-14.26,;8.06,-13.49,;9.4,-14.25,;10.73,-13.48,;12.06,-14.26,;13.39,-13.49,;13.39,-11.95,;12.04,-11.18,;10.72,-11.95,;5.41,-11.95,;4.08,-11.18,;2.74,-11.94,;3.49,-13.27,;4.62,-12.15,)|
Show InChI InChI=1S/C29H29F4N2O3/c30-22-5-4-6-23(17-22)34(18-20-15-25(31)28(33)26(32)16-20)29(36)38-27-19-35(11-9-21(27)10-12-35)13-14-37-24-7-2-1-3-8-24/h1-8,15-17,21,27H,9-14,18-19H2/q+1/t21?,27-,35?/m0/s1
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n/an/a 1.10n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50344292
PNG
((R)-1-(2-phenoxyethyl)-3-(phenyl(thiophen-2-ylmeth...)
Show SMILES O=C(O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)N(Cc1cccs1)c1ccccc1 |r,wD:3.2,(-.81,1.63,;-.81,.09,;.52,-.68,;1.85,.09,;3.19,-.68,;4.52,.08,;5.84,-.68,;7.17,.09,;8.51,-.68,;9.84,.09,;11.17,-.69,;12.5,.08,;12.5,1.63,;11.16,2.39,;9.83,1.62,;4.52,1.62,;3.19,2.39,;1.85,1.63,;2.61,.3,;3.73,1.42,;-2.15,-.68,;-2.15,-2.22,;-3.48,-2.99,;-4.89,-2.37,;-5.92,-3.51,;-5.15,-4.84,;-3.65,-4.52,;-3.48,.09,;-3.47,1.64,;-4.8,2.41,;-6.14,1.64,;-6.13,.09,;-4.8,-.68,)|
Show InChI InChI=1S/C27H31N2O3S/c30-27(28(20-25-12-7-19-33-25)23-8-3-1-4-9-23)32-26-21-29(15-13-22(26)14-16-29)17-18-31-24-10-5-2-6-11-24/h1-12,19,22,26H,13-18,20-21H2/q+1/t22?,26-,29?/m0/s1
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n/an/a 1.10n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))		BDBM50344303
PNG
((R)-quinuclidin-3-yl benzyl(phenyl)carbamate | CHE...)
Show SMILES O=C(O[C@H]1CN2CCC1CC2)N(Cc1ccccc1)c1ccccc1 |r,wD:3.2,(10.51,3.48,;10.51,1.94,;11.85,1.17,;13.18,1.94,;14.51,1.17,;15.84,1.93,;15.85,3.47,;14.51,4.25,;13.17,3.48,;13.93,2.15,;15.06,3.27,;9.18,1.17,;9.18,-.37,;7.84,-1.14,;6.51,-.36,;5.18,-1.13,;5.18,-2.67,;6.52,-3.44,;7.85,-2.66,;7.84,1.94,;7.85,3.49,;6.52,4.26,;5.19,3.49,;5.19,1.94,;6.52,1.18,)|
Show InChI InChI=1S/C21H24N2O2/c24-21(25-20-16-22-13-11-18(20)12-14-22)23(19-9-5-2-6-10-19)15-17-7-3-1-4-8-17/h1-10,18,20H,11-16H2/t20-/m0/s1
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n/an/a 1.20n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))		BDBM50344300
PNG
((R)-1-(2-phenoxyethyl)-3-(m-tolyl(2,4,5-trifluorob...)
Show SMILES Cc1cccc(c1)N(Cc1cc(F)c(F)cc1F)C(=O)O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2 |r,wD:21.22,(19.44,3.82,;19.44,2.28,;18.1,1.51,;18.11,-.04,;19.44,-.8,;20.76,-.03,;20.77,1.51,;22.1,-.8,;22.1,-2.34,;20.76,-3.11,;19.43,-2.33,;18.1,-3.1,;16.77,-2.33,;18.1,-4.64,;16.77,-5.41,;19.44,-5.41,;20.77,-4.64,;22.11,-5.4,;23.43,-.03,;23.43,1.51,;24.76,-.8,;26.1,-.03,;27.43,-.81,;28.76,-.04,;30.08,-.81,;31.42,-.04,;32.75,-.81,;34.08,-.04,;35.41,-.81,;36.74,-.04,;36.74,1.5,;35.4,2.27,;34.07,1.5,;28.77,1.5,;27.43,2.27,;26.09,1.5,;26.85,.18,;27.98,1.3,)|
Show InChI InChI=1S/C30H32F3N2O3/c1-21-6-5-7-24(16-21)34(19-23-17-27(32)28(33)18-26(23)31)30(36)38-29-20-35(12-10-22(29)11-13-35)14-15-37-25-8-3-2-4-9-25/h2-9,16-18,22,29H,10-15,19-20H2,1H3/q+1/t22?,29-,35?/m0/s1
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n/an/a 1.20n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50344288
PNG
((R)-3-(benzyl(phenyl)carbamoyloxy)-1-(3-(thiophen-...)
Show SMILES O=C(O[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)N(Cc1ccccc1)c1ccccc1 |r,wD:3.2,(.46,-25.61,;.46,-27.15,;1.8,-27.92,;3.13,-27.15,;4.46,-27.93,;5.79,-27.17,;7.12,-27.93,;8.45,-27.16,;9.78,-27.93,;11.12,-27.16,;11.28,-25.62,;12.78,-25.3,;13.55,-26.63,;12.52,-27.78,;5.8,-25.63,;4.47,-24.85,;3.12,-25.62,;3.88,-26.94,;5.01,-25.82,;-.87,-27.92,;-.87,-29.46,;-2.2,-30.23,;-3.54,-29.45,;-4.87,-30.22,;-4.87,-31.76,;-3.53,-32.53,;-2.2,-31.76,;-2.2,-27.15,;-2.2,-25.61,;-3.53,-24.84,;-4.86,-25.61,;-4.86,-27.16,;-3.53,-27.92,)|
Show InChI InChI=1S/C28H33N2O2S/c31-28(29(25-11-5-2-6-12-25)21-23-9-3-1-4-10-23)32-27-22-30(18-15-24(27)16-19-30)17-7-13-26-14-8-20-33-26/h1-6,8-12,14,20,24,27H,7,13,15-19,21-22H2/q+1/t24?,27-,30?/m0/s1
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n/an/a 1.40n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50344298
PNG
((R)-3-(butyl(phenyl)carbamoyloxy)-1-(2-phenoxyethy...)
Show SMILES CCCCN(C(=O)O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)c1ccccc1 |r,wD:8.7,(-5.8,-41.35,;-4.46,-40.58,;-3.13,-41.35,;-1.8,-40.58,;-1.8,-39.04,;-.46,-38.27,;-.46,-36.73,;.87,-39.04,;2.2,-38.27,;3.54,-39.05,;4.87,-38.29,;6.19,-39.05,;7.52,-38.28,;8.86,-39.05,;10.19,-38.28,;11.52,-39.05,;12.85,-38.28,;12.85,-36.74,;11.51,-35.97,;10.18,-36.75,;4.87,-36.75,;3.54,-35.97,;2.2,-36.74,;2.96,-38.06,;4.08,-36.94,;-3.13,-38.27,;-3.12,-36.73,;-4.45,-35.96,;-5.79,-36.73,;-5.78,-38.28,;-4.45,-39.04,)|
Show InChI InChI=1S/C26H35N2O3/c1-2-3-16-27(23-10-6-4-7-11-23)26(29)31-25-21-28(17-14-22(25)15-18-28)19-20-30-24-12-8-5-9-13-24/h4-13,22,25H,2-3,14-21H2,1H3/q+1/t22?,25-,28?/m0/s1
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n/an/a 1.40n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))		BDBM50344282
PNG
((R)-quinuclidin-3-yl m-tolyl(2,4,5-trifluorobenzyl...)
Show SMILES Cc1cccc(c1)N(Cc1cc(F)c(F)cc1F)C(=O)O[C@H]1CN2CCC1CC2 |r,wD:21.22,(-3.76,3.63,;-3.76,2.09,;-5.1,1.32,;-5.09,-.22,;-3.76,-.99,;-2.43,-.22,;-2.43,1.32,;-1.1,-.99,;-1.1,-2.53,;-2.43,-3.3,;-3.77,-2.53,;-5.1,-3.29,;-6.43,-2.52,;-5.1,-4.84,;-6.43,-5.61,;-3.76,-5.61,;-2.43,-4.83,;-1.09,-5.6,;.24,-.22,;.24,1.32,;1.57,-.99,;2.9,-.22,;4.24,-.99,;5.57,-.23,;5.57,1.31,;4.24,2.08,;2.9,1.32,;3.66,-.01,;4.78,1.11,)|
Show InChI InChI=1S/C22H23F3N2O2/c1-14-3-2-4-17(9-14)27(12-16-10-19(24)20(25)11-18(16)23)22(28)29-21-13-26-7-5-15(21)6-8-26/h2-4,9-11,15,21H,5-8,12-13H2,1H3/t21-/m0/s1
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n/an/a 1.40n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))		BDBM50344283
PNG
((R)-quinuclidin-3-yl 3-fluorophenyl(3,4,5-trifluor...)
Show SMILES Fc1cccc(c1)N(Cc1cc(F)c(F)c(F)c1)C(=O)O[C@H]1CN2CCC1CC2 |r,wD:21.22,(13.85,4.33,;13.85,2.79,;12.51,2.02,;12.52,.47,;13.85,-.29,;15.18,.47,;15.18,2.02,;16.51,-.3,;16.51,-1.84,;15.18,-2.61,;13.84,-1.83,;12.51,-2.6,;11.18,-1.83,;12.51,-4.14,;11.18,-4.92,;13.85,-4.91,;13.86,-6.45,;15.18,-4.14,;17.85,.47,;17.85,2.01,;19.18,-.3,;20.51,.47,;21.84,-.3,;23.17,.46,;23.18,2,;21.85,2.78,;20.51,2.01,;21.26,.68,;22.39,1.8,)|
Show InChI InChI=1S/C21H20F4N2O2/c22-15-2-1-3-16(10-15)27(11-13-8-17(23)20(25)18(24)9-13)21(28)29-19-12-26-6-4-14(19)5-7-26/h1-3,8-10,14,19H,4-7,11-12H2/t19-/m0/s1
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n/an/a 1.5n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50344281
PNG
((R)-quinuclidin-3-yl 3-fluorobenzyl(3-fluorophenyl...)
Show SMILES Fc1cccc(CN(C(=O)O[C@H]2CN3CCC2CC3)c2cccc(F)c2)c1 |r,wD:11.10,(23.52,-50.24,;23.52,-48.7,;22.17,-47.93,;22.18,-46.38,;23.51,-45.62,;24.84,-46.39,;26.17,-45.62,;26.17,-44.08,;27.51,-43.31,;27.51,-41.77,;28.84,-44.08,;30.17,-43.31,;31.5,-44.09,;32.83,-43.33,;32.84,-41.79,;31.51,-41.01,;30.17,-41.78,;30.92,-43.1,;32.05,-41.98,;24.84,-43.31,;23.52,-44.08,;22.19,-43.32,;22.18,-41.77,;23.52,-41,;23.52,-39.46,;24.85,-41.77,;24.84,-47.92,)|
Show InChI InChI=1S/C21H22F2N2O2/c22-17-4-1-3-15(11-17)13-25(19-6-2-5-18(23)12-19)21(26)27-20-14-24-9-7-16(20)8-10-24/h1-6,11-12,16,20H,7-10,13-14H2/t20-/m0/s1
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n/an/a 1.5n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50344287
PNG
((R)-3-(benzyl(phenyl)carbamoyloxy)-1-(3-phenylprop...)
Show SMILES O=C(O[C@H]1C[N+]2(CCCc3ccccc3)CCC1CC2)N(Cc1ccccc1)c1ccccc1 |r,wD:3.2,(20.32,-12.49,;20.32,-14.03,;21.65,-14.8,;22.99,-14.03,;24.32,-14.81,;25.65,-14.04,;26.97,-14.81,;28.31,-14.04,;29.64,-14.81,;30.97,-14.04,;32.3,-14.81,;33.63,-14.04,;33.63,-12.5,;32.29,-11.73,;30.96,-12.5,;25.66,-12.5,;24.32,-11.73,;22.98,-12.5,;23.74,-13.82,;24.87,-12.7,;18.99,-14.8,;18.99,-16.34,;17.65,-17.11,;16.32,-16.33,;14.99,-17.1,;14.99,-18.64,;16.33,-19.41,;17.66,-18.64,;17.65,-14.03,;17.66,-12.49,;16.33,-11.72,;14.99,-12.49,;15,-14.04,;16.33,-14.8,)|
Show InChI InChI=1S/C30H35N2O2/c33-30(31(28-16-8-3-9-17-28)23-26-13-6-2-7-14-26)34-29-24-32(21-18-27(29)19-22-32)20-10-15-25-11-4-1-5-12-25/h1-9,11-14,16-17,27,29H,10,15,18-24H2/q+1/t27?,29-,32?/m0/s1
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n/an/a 1.5n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50344294
PNG
((R)-1-(2-phenoxyethyl)-3-(phenyl(thiophen-3-ylmeth...)
Show SMILES O=C(O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)N(Cc1ccsc1)c1ccccc1 |r,wD:3.2,(.53,-12.66,;.53,-14.2,;1.87,-14.97,;3.2,-14.2,;4.53,-14.98,;5.86,-14.22,;7.19,-14.98,;8.52,-14.21,;9.85,-14.98,;11.19,-14.21,;12.51,-14.98,;13.85,-14.21,;13.85,-12.67,;12.5,-11.9,;11.18,-12.68,;5.87,-12.68,;4.54,-11.9,;3.19,-12.67,;3.95,-13.99,;5.08,-12.87,;-.8,-14.97,;-.8,-16.51,;-2.13,-17.28,;-3.54,-16.66,;-4.57,-17.8,;-3.8,-19.14,;-2.29,-18.82,;-2.13,-14.2,;-2.13,-12.66,;-3.46,-11.89,;-4.79,-12.66,;-4.79,-14.21,;-3.46,-14.97,)|
Show InChI InChI=1S/C27H31N2O3S/c30-27(28(19-22-13-18-33-21-22)24-7-3-1-4-8-24)32-26-20-29(14-11-23(26)12-15-29)16-17-31-25-9-5-2-6-10-25/h1-10,13,18,21,23,26H,11-12,14-17,19-20H2/q+1/t23?,26-,29?/m0/s1
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n/an/a 1.60n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50344291
PNG
((R)-3-(phenyl(thiophen-2-ylmethyl)carbamoyloxy)-1-...)
Show SMILES O=C(O[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)N(Cc1cccs1)c1ccccc1 |r,wD:3.2,(21.03,-39.07,;21.03,-40.61,;22.36,-41.38,;23.69,-40.61,;25.03,-41.38,;26.36,-40.62,;27.68,-41.39,;29.01,-40.61,;30.35,-41.38,;31.68,-40.61,;31.84,-39.07,;33.35,-38.75,;34.12,-40.09,;33.09,-41.23,;26.36,-39.08,;25.03,-38.31,;23.69,-39.07,;24.45,-40.4,;25.57,-39.28,;19.69,-41.38,;19.69,-42.92,;18.36,-43.69,;16.95,-43.07,;15.92,-44.21,;16.69,-45.55,;18.19,-45.23,;18.36,-40.61,;18.37,-39.07,;17.04,-38.3,;15.7,-39.07,;15.71,-40.61,;17.04,-41.38,)|
Show InChI InChI=1S/C26H31N2O2S2/c29-26(27(19-24-11-6-18-32-24)22-7-2-1-3-8-22)30-25-20-28(15-12-21(25)13-16-28)14-4-9-23-10-5-17-31-23/h1-3,5-8,10-11,17-18,21,25H,4,9,12-16,19-20H2/q+1/t21?,25-,28?/m0/s1
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n/an/a 1.60n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))		BDBM50344274
PNG
((R)-quinuclidin-3-yl pentyl(phenyl)carbamate | CHE...)
Show SMILES CCCCCN(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1 |r,wD:9.8,(12.29,-26.84,;12.29,-25.3,;10.95,-24.53,;10.95,-22.99,;9.62,-22.22,;9.62,-20.68,;10.95,-19.91,;10.95,-18.37,;12.29,-20.68,;13.62,-19.91,;14.95,-20.69,;16.28,-19.92,;16.29,-18.38,;14.96,-17.61,;13.62,-18.38,;14.37,-19.7,;15.5,-18.58,;8.29,-19.91,;8.3,-18.37,;6.96,-17.6,;5.63,-18.37,;5.63,-19.92,;6.97,-20.68,)|
Show InChI InChI=1S/C19H28N2O2/c1-2-3-7-12-21(17-8-5-4-6-9-17)19(22)23-18-15-20-13-10-16(18)11-14-20/h4-6,8-9,16,18H,2-3,7,10-15H2,1H3/t18-/m0/s1
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n/an/a 1.70n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50344289
PNG
((R)-3-(benzyl(phenyl)carbamoyloxy)-1-(2-phenoxyeth...)
Show SMILES O=C(O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)N(Cc1ccccc1)c1ccccc1 |r,wD:3.2,(22.07,-23.51,;22.07,-25.05,;23.4,-25.82,;24.74,-25.05,;26.07,-25.83,;27.4,-25.07,;28.72,-25.83,;30.06,-25.06,;31.39,-25.83,;32.72,-25.06,;34.05,-25.83,;35.38,-25.06,;35.38,-23.52,;34.04,-22.75,;32.71,-23.53,;27.41,-23.53,;26.07,-22.75,;24.73,-23.52,;25.49,-24.84,;26.62,-23.72,;20.74,-25.82,;20.74,-27.36,;19.4,-28.13,;18.07,-27.35,;16.74,-28.12,;16.74,-29.66,;18.08,-30.43,;19.41,-29.66,;19.4,-25.05,;19.41,-23.51,;18.08,-22.74,;16.74,-23.51,;16.75,-25.06,;18.08,-25.82,)|
Show InChI InChI=1S/C29H33N2O3/c32-29(30(26-12-6-2-7-13-26)22-24-10-4-1-5-11-24)34-28-23-31(18-16-25(28)17-19-31)20-21-33-27-14-8-3-9-15-27/h1-15,25,28H,16-23H2/q+1/t25?,28-,31?/m0/s1
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n/an/a 1.70n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50344270
PNG
((R)-quinuclidin-3-yl phenyl(thiophen-2-ylmethyl)ca...)
Show SMILES O=C(O[C@H]1CN2CCC1CC2)N(Cc1cccs1)c1ccccc1 |r,wD:3.2,(-3.52,-8.18,;-3.52,-9.72,;-2.19,-10.49,;-.85,-9.72,;.48,-10.5,;1.81,-9.74,;1.82,-8.2,;.48,-7.42,;-.86,-8.19,;-.1,-9.51,;1.03,-8.39,;-4.85,-10.49,;-4.85,-12.03,;-6.19,-12.8,;-7.6,-12.18,;-8.63,-13.33,;-7.86,-14.66,;-6.36,-14.34,;-6.19,-9.72,;-6.19,-8.18,;-7.52,-7.41,;-8.85,-8.18,;-8.85,-9.73,;-7.52,-10.49,)|
Show InChI InChI=1S/C19H22N2O2S/c22-19(23-18-14-20-10-8-15(18)9-11-20)21(13-17-7-4-12-24-17)16-5-2-1-3-6-16/h1-7,12,15,18H,8-11,13-14H2/t18-/m0/s1
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n/an/a 1.80n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50344293
PNG
((R)-3-(phenyl(thiophen-3-ylmethyl)carbamoyloxy)-1-...)
Show SMILES O=C(O[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)N(Cc1ccsc1)c1ccccc1 |r,wD:3.2,(21.62,.98,;21.62,-.56,;22.95,-1.33,;24.29,-.56,;25.62,-1.34,;26.95,-.57,;28.27,-1.34,;29.61,-.57,;30.94,-1.34,;32.27,-.57,;32.43,.97,;33.93,1.29,;34.71,-.05,;33.68,-1.19,;26.95,.97,;25.62,1.74,;24.28,.97,;25.04,-.35,;26.16,.77,;20.28,-1.33,;20.28,-2.87,;18.95,-3.64,;17.55,-3.02,;16.52,-4.16,;17.29,-5.49,;18.79,-5.17,;18.95,-.56,;18.96,.98,;17.63,1.75,;16.29,.98,;16.3,-.57,;17.63,-1.33,)|
Show InChI InChI=1S/C26H31N2O2S2/c29-26(27(18-21-12-17-31-20-21)23-6-2-1-3-7-23)30-25-19-28(14-10-22(25)11-15-28)13-4-8-24-9-5-16-32-24/h1-3,5-7,9,12,16-17,20,22,25H,4,8,10-11,13-15,18-19H2/q+1/t22?,25-,28?/m0/s1
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n/an/a 2n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50344297
PNG
((R)-3-(butyl(phenyl)carbamoyloxy)-1-(3-(thiophen-2...)
Show SMILES CCCCN(C(=O)O[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)c1ccccc1 |r,wD:8.7,(18.41,-29.52,;19.75,-28.75,;21.08,-29.52,;22.42,-28.75,;22.42,-27.21,;23.75,-26.44,;23.75,-24.9,;25.08,-27.21,;26.42,-26.44,;27.75,-27.21,;29.08,-26.45,;30.4,-27.21,;31.74,-26.44,;33.07,-27.21,;34.4,-26.44,;34.56,-24.9,;36.07,-24.58,;36.84,-25.91,;35.81,-27.06,;29.09,-24.91,;27.75,-24.14,;26.41,-24.9,;27.17,-26.23,;28.3,-25.11,;21.08,-26.44,;21.09,-24.89,;19.76,-24.12,;18.42,-24.89,;18.43,-26.44,;19.76,-27.21,)|
Show InChI InChI=1S/C25H35N2O2S/c1-2-3-15-26(22-9-5-4-6-10-22)25(28)29-24-20-27(17-13-21(24)14-18-27)16-7-11-23-12-8-19-30-23/h4-6,8-10,12,19,21,24H,2-3,7,11,13-18,20H2,1H3/q+1/t21?,24-,27?/m0/s1
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n/an/a 2n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50344300
PNG
((R)-1-(2-phenoxyethyl)-3-(m-tolyl(2,4,5-trifluorob...)
Show SMILES Cc1cccc(c1)N(Cc1cc(F)c(F)cc1F)C(=O)O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2 |r,wD:21.22,(19.44,3.82,;19.44,2.28,;18.1,1.51,;18.11,-.04,;19.44,-.8,;20.76,-.03,;20.77,1.51,;22.1,-.8,;22.1,-2.34,;20.76,-3.11,;19.43,-2.33,;18.1,-3.1,;16.77,-2.33,;18.1,-4.64,;16.77,-5.41,;19.44,-5.41,;20.77,-4.64,;22.11,-5.4,;23.43,-.03,;23.43,1.51,;24.76,-.8,;26.1,-.03,;27.43,-.81,;28.76,-.04,;30.08,-.81,;31.42,-.04,;32.75,-.81,;34.08,-.04,;35.41,-.81,;36.74,-.04,;36.74,1.5,;35.4,2.27,;34.07,1.5,;28.77,1.5,;27.43,2.27,;26.09,1.5,;26.85,.18,;27.98,1.3,)|
Show InChI InChI=1S/C30H32F3N2O3/c1-21-6-5-7-24(16-21)34(19-23-17-27(32)28(33)18-26(23)31)30(36)38-29-20-35(12-10-22(29)11-13-35)14-15-37-25-8-3-2-4-9-25/h2-9,16-18,22,29H,10-15,19-20H2,1H3/q+1/t22?,29-,35?/m0/s1
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n/an/a 2.40n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50344277
PNG
((R)-quinuclidin-3-yl bis(thiophen-2-ylmethyl)carba...)
Show SMILES O=C(O[C@H]1CN2CCC1CC2)N(Cc1cccs1)Cc1cccs1 |r,wD:3.2,(10.96,-30.88,;10.96,-32.42,;12.3,-33.19,;13.63,-32.42,;14.96,-33.19,;16.29,-32.43,;16.3,-30.89,;14.97,-30.12,;13.62,-30.88,;14.38,-32.21,;15.51,-31.09,;9.63,-33.19,;8.3,-32.42,;8.3,-30.88,;9.53,-29.97,;9.06,-28.5,;7.52,-28.5,;7.04,-29.97,;9.63,-34.73,;8.3,-35.5,;6.89,-34.88,;5.86,-36.03,;6.63,-37.36,;8.13,-37.04,)|
Show InChI InChI=1S/C18H22N2O2S2/c21-18(22-17-13-19-7-5-14(17)6-8-19)20(11-15-3-1-9-23-15)12-16-4-2-10-24-16/h1-4,9-10,14,17H,5-8,11-13H2/t17-/m0/s1
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n/an/a 2.40n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))		BDBM50344281
PNG
((R)-quinuclidin-3-yl 3-fluorobenzyl(3-fluorophenyl...)
Show SMILES Fc1cccc(CN(C(=O)O[C@H]2CN3CCC2CC3)c2cccc(F)c2)c1 |r,wD:11.10,(23.52,-50.24,;23.52,-48.7,;22.17,-47.93,;22.18,-46.38,;23.51,-45.62,;24.84,-46.39,;26.17,-45.62,;26.17,-44.08,;27.51,-43.31,;27.51,-41.77,;28.84,-44.08,;30.17,-43.31,;31.5,-44.09,;32.83,-43.33,;32.84,-41.79,;31.51,-41.01,;30.17,-41.78,;30.92,-43.1,;32.05,-41.98,;24.84,-43.31,;23.52,-44.08,;22.19,-43.32,;22.18,-41.77,;23.52,-41,;23.52,-39.46,;24.85,-41.77,;24.84,-47.92,)|
Show InChI InChI=1S/C21H22F2N2O2/c22-17-4-1-3-15(11-17)13-25(19-6-2-5-18(23)12-19)21(26)27-20-14-24-9-7-16(20)8-10-24/h1-6,11-12,16,20H,7-10,13-14H2/t20-/m0/s1
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n/an/a 2.40n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50344296
PNG
((R)-3-(butyl(phenyl)carbamoyloxy)-1-(3-phenylpropy...)
Show SMILES CCCCN(C(=O)O[C@H]1C[N+]2(CCCc3ccccc3)CCC1CC2)c1ccccc1 |r,wD:8.7,(-3.06,-29.35,;-1.73,-28.58,;-.39,-29.35,;.94,-28.58,;.94,-27.04,;2.27,-26.27,;2.27,-24.73,;3.61,-27.04,;4.94,-26.27,;6.27,-27.05,;7.6,-26.29,;8.93,-27.05,;10.26,-26.28,;11.6,-27.05,;12.93,-26.28,;14.26,-27.05,;15.59,-26.28,;15.59,-24.74,;14.25,-23.97,;12.92,-24.75,;7.61,-24.75,;6.28,-23.97,;4.94,-24.74,;5.69,-26.06,;6.82,-24.94,;-.39,-26.27,;-.38,-24.73,;-1.72,-23.96,;-3.05,-24.73,;-3.05,-26.28,;-1.71,-27.04,)|
Show InChI InChI=1S/C27H37N2O2/c1-2-3-18-28(25-14-8-5-9-15-25)27(30)31-26-22-29(20-16-24(26)17-21-29)19-10-13-23-11-6-4-7-12-23/h4-9,11-12,14-15,24,26H,2-3,10,13,16-22H2,1H3/q+1/t24?,26-,29?/m0/s1
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n/an/a 2.5n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50344285
PNG
(CHEMBL1779047 | quinuclidin-4-yl biphenyl-2-ylcarb...)
Show SMILES O=C(Nc1ccccc1-c1ccccc1)OC12CCN(CC1)CC2
Show InChI InChI=1S/C20H22N2O2/c23-19(24-20-10-13-22(14-11-20)15-12-20)21-18-9-5-4-8-17(18)16-6-2-1-3-7-16/h1-9H,10-15H2,(H,21,23)
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n/an/a 3n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50344299
PNG
((R)-1-(3-phenylpropyl)-3-(m-tolyl(2,4,5-trifluorob...)
Show SMILES Cc1cccc(c1)N(Cc1cc(F)c(F)cc1F)C(=O)O[C@H]1C[N+]2(CCCc3ccccc3)CCC1CC2 |r,wD:21.22,(-4.97,4.35,;-4.97,2.81,;-6.31,2.04,;-6.3,.49,;-4.97,-.27,;-3.65,.5,;-3.64,2.04,;-2.32,-.27,;-2.32,-1.81,;-3.65,-2.58,;-4.98,-1.8,;-6.31,-2.57,;-7.65,-1.8,;-6.32,-4.11,;-7.65,-4.89,;-4.97,-4.88,;-3.65,-4.11,;-2.31,-4.87,;-.98,.5,;-.98,2.04,;.35,-.27,;1.68,.5,;3.01,-.28,;4.34,.48,;5.67,-.28,;7,.49,;8.34,-.28,;9.67,.49,;11,-.28,;12.33,.49,;12.33,2.03,;10.99,2.8,;9.66,2.02,;4.35,2.02,;3.02,2.8,;1.68,2.03,;2.43,.71,;3.56,1.83,)|
Show InChI InChI=1S/C31H34F3N2O2/c1-22-7-5-11-26(17-22)35(20-25-18-28(33)29(34)19-27(25)32)31(37)38-30-21-36(15-12-24(30)13-16-36)14-6-10-23-8-3-2-4-9-23/h2-5,7-9,11,17-19,24,30H,6,10,12-16,20-21H2,1H3/q+1/t24?,30-,36?/m0/s1
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n/an/a 3n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50344291
PNG
((R)-3-(phenyl(thiophen-2-ylmethyl)carbamoyloxy)-1-...)
Show SMILES O=C(O[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)N(Cc1cccs1)c1ccccc1 |r,wD:3.2,(21.03,-39.07,;21.03,-40.61,;22.36,-41.38,;23.69,-40.61,;25.03,-41.38,;26.36,-40.62,;27.68,-41.39,;29.01,-40.61,;30.35,-41.38,;31.68,-40.61,;31.84,-39.07,;33.35,-38.75,;34.12,-40.09,;33.09,-41.23,;26.36,-39.08,;25.03,-38.31,;23.69,-39.07,;24.45,-40.4,;25.57,-39.28,;19.69,-41.38,;19.69,-42.92,;18.36,-43.69,;16.95,-43.07,;15.92,-44.21,;16.69,-45.55,;18.19,-45.23,;18.36,-40.61,;18.37,-39.07,;17.04,-38.3,;15.7,-39.07,;15.71,-40.61,;17.04,-41.38,)|
Show InChI InChI=1S/C26H31N2O2S2/c29-26(27(19-24-11-6-18-32-24)22-7-2-1-3-8-22)30-25-20-28(15-12-21(25)13-16-28)14-4-9-23-10-5-17-31-23/h1-3,5-8,10-11,17-18,21,25H,4,9,12-16,19-20H2/q+1/t21?,25-,28?/m0/s1
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n/an/a 3.20n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))		BDBM50344269
PNG
((R)-quinuclidin-3-yl phenethyl(phenyl)carbamate | ...)
Show SMILES O=C(O[C@H]1CN2CCC1CC2)N(CCc1ccccc1)c1ccccc1 |r,wD:3.2,(25.48,4.31,;25.48,2.77,;26.82,2,;28.15,2.77,;29.48,1.99,;30.81,2.76,;30.82,4.3,;29.49,5.07,;28.15,4.3,;28.9,2.98,;30.03,4.1,;24.15,2,;24.15,.46,;22.82,-.31,;22.82,-1.85,;21.48,-2.61,;21.48,-4.15,;22.81,-4.92,;24.15,-4.15,;24.14,-2.61,;22.82,2.77,;22.83,4.31,;21.49,5.08,;20.16,4.31,;20.16,2.76,;21.5,2,)|
Show InChI InChI=1S/C22H26N2O2/c25-22(26-21-17-23-14-12-19(21)13-15-23)24(20-9-5-2-6-10-20)16-11-18-7-3-1-4-8-18/h1-10,19,21H,11-17H2/t21-/m0/s1
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n/an/a 3.60n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50344303
PNG
((R)-quinuclidin-3-yl benzyl(phenyl)carbamate | CHE...)
Show SMILES O=C(O[C@H]1CN2CCC1CC2)N(Cc1ccccc1)c1ccccc1 |r,wD:3.2,(10.51,3.48,;10.51,1.94,;11.85,1.17,;13.18,1.94,;14.51,1.17,;15.84,1.93,;15.85,3.47,;14.51,4.25,;13.17,3.48,;13.93,2.15,;15.06,3.27,;9.18,1.17,;9.18,-.37,;7.84,-1.14,;6.51,-.36,;5.18,-1.13,;5.18,-2.67,;6.52,-3.44,;7.85,-2.66,;7.84,1.94,;7.85,3.49,;6.52,4.26,;5.19,3.49,;5.19,1.94,;6.52,1.18,)|
Show InChI InChI=1S/C21H24N2O2/c24-21(25-20-16-22-13-11-18(20)12-14-22)23(19-9-5-2-6-10-19)15-17-7-3-1-4-8-17/h1-10,18,20H,11-16H2/t20-/m0/s1
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n/an/a 3.70n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50344289
PNG
((R)-3-(benzyl(phenyl)carbamoyloxy)-1-(2-phenoxyeth...)
Show SMILES O=C(O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)N(Cc1ccccc1)c1ccccc1 |r,wD:3.2,(22.07,-23.51,;22.07,-25.05,;23.4,-25.82,;24.74,-25.05,;26.07,-25.83,;27.4,-25.07,;28.72,-25.83,;30.06,-25.06,;31.39,-25.83,;32.72,-25.06,;34.05,-25.83,;35.38,-25.06,;35.38,-23.52,;34.04,-22.75,;32.71,-23.53,;27.41,-23.53,;26.07,-22.75,;24.73,-23.52,;25.49,-24.84,;26.62,-23.72,;20.74,-25.82,;20.74,-27.36,;19.4,-28.13,;18.07,-27.35,;16.74,-28.12,;16.74,-29.66,;18.08,-30.43,;19.41,-29.66,;19.4,-25.05,;19.41,-23.51,;18.08,-22.74,;16.74,-23.51,;16.75,-25.06,;18.08,-25.82,)|
Show InChI InChI=1S/C29H33N2O3/c32-29(30(26-12-6-2-7-13-26)22-24-10-4-1-5-11-24)34-28-23-31(18-16-25(28)17-19-31)20-21-33-27-14-8-3-9-15-27/h1-15,25,28H,16-23H2/q+1/t25?,28-,31?/m0/s1
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n/an/a 3.90n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50344287
PNG
((R)-3-(benzyl(phenyl)carbamoyloxy)-1-(3-phenylprop...)
Show SMILES O=C(O[C@H]1C[N+]2(CCCc3ccccc3)CCC1CC2)N(Cc1ccccc1)c1ccccc1 |r,wD:3.2,(20.32,-12.49,;20.32,-14.03,;21.65,-14.8,;22.99,-14.03,;24.32,-14.81,;25.65,-14.04,;26.97,-14.81,;28.31,-14.04,;29.64,-14.81,;30.97,-14.04,;32.3,-14.81,;33.63,-14.04,;33.63,-12.5,;32.29,-11.73,;30.96,-12.5,;25.66,-12.5,;24.32,-11.73,;22.98,-12.5,;23.74,-13.82,;24.87,-12.7,;18.99,-14.8,;18.99,-16.34,;17.65,-17.11,;16.32,-16.33,;14.99,-17.1,;14.99,-18.64,;16.33,-19.41,;17.66,-18.64,;17.65,-14.03,;17.66,-12.49,;16.33,-11.72,;14.99,-12.49,;15,-14.04,;16.33,-14.8,)|
Show InChI InChI=1S/C30H35N2O2/c33-30(31(28-16-8-3-9-17-28)23-26-13-6-2-7-14-26)34-29-24-32(21-18-27(29)19-22-32)20-10-15-25-11-4-1-5-12-25/h1-9,11-14,16-17,27,29H,10,15,18-24H2/q+1/t27?,29-,32?/m0/s1
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n/an/a 4n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))		BDBM50344273
PNG
((R)-quinuclidin-3-yl butyl(phenyl)carbamate | CHEM...)
Show SMILES CCCCN(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1 |r,wD:8.7,(-8.01,-25.61,;-6.68,-24.84,;-6.68,-23.3,;-5.34,-22.53,;-5.34,-20.99,;-4.01,-20.22,;-4.01,-18.68,;-2.68,-20.99,;-1.34,-20.22,;-.01,-21,;1.32,-20.24,;1.33,-18.7,;-.01,-17.92,;-1.35,-18.69,;-.59,-20.01,;.54,-18.89,;-6.68,-20.22,;-6.67,-18.68,;-8,-17.91,;-9.34,-18.68,;-9.33,-20.23,;-8,-20.99,)|
Show InChI InChI=1S/C18H26N2O2/c1-2-3-11-20(16-7-5-4-6-8-16)18(21)22-17-14-19-12-9-15(17)10-13-19/h4-8,15,17H,2-3,9-14H2,1H3/t17-/m0/s1
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n/an/a 4.30n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50344271
PNG
((R)-quinuclidin-3-yl phenyl(thiophen-3-ylmethyl)ca...)
Show SMILES O=C(O[C@H]1CN2CCC1CC2)N(Cc1ccsc1)c1ccccc1 |r,wD:3.2,(10.43,-7.93,;10.43,-9.47,;11.77,-10.24,;13.1,-9.47,;14.43,-10.25,;15.76,-9.49,;15.77,-7.95,;14.44,-7.17,;13.1,-7.94,;13.85,-9.26,;14.98,-8.14,;9.1,-10.24,;9.1,-11.78,;7.77,-12.55,;6.36,-11.94,;5.33,-13.08,;6.1,-14.41,;7.61,-14.09,;7.77,-9.47,;7.78,-7.93,;6.44,-7.16,;5.11,-7.93,;5.11,-9.48,;6.45,-10.24,)|
Show InChI InChI=1S/C19H22N2O2S/c22-19(23-18-13-20-9-6-16(18)7-10-20)21(12-15-8-11-24-14-15)17-4-2-1-3-5-17/h1-5,8,11,14,16,18H,6-7,9-10,12-13H2/t18-/m0/s1
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n/an/a 4.70n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))		BDBM50344277
PNG
((R)-quinuclidin-3-yl bis(thiophen-2-ylmethyl)carba...)
Show SMILES O=C(O[C@H]1CN2CCC1CC2)N(Cc1cccs1)Cc1cccs1 |r,wD:3.2,(10.96,-30.88,;10.96,-32.42,;12.3,-33.19,;13.63,-32.42,;14.96,-33.19,;16.29,-32.43,;16.3,-30.89,;14.97,-30.12,;13.62,-30.88,;14.38,-32.21,;15.51,-31.09,;9.63,-33.19,;8.3,-32.42,;8.3,-30.88,;9.53,-29.97,;9.06,-28.5,;7.52,-28.5,;7.04,-29.97,;9.63,-34.73,;8.3,-35.5,;6.89,-34.88,;5.86,-36.03,;6.63,-37.36,;8.13,-37.04,)|
Show InChI InChI=1S/C18H22N2O2S2/c21-18(22-17-13-19-7-5-14(17)6-8-19)20(11-15-3-1-9-23-15)12-16-4-2-10-24-16/h1-4,9-10,14,17H,5-8,11-13H2/t17-/m0/s1
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n/an/a 5.90n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))		BDBM50344285
PNG
(CHEMBL1779047 | quinuclidin-4-yl biphenyl-2-ylcarb...)
Show SMILES O=C(Nc1ccccc1-c1ccccc1)OC12CCN(CC1)CC2
Show InChI InChI=1S/C20H22N2O2/c23-19(24-20-10-13-22(14-11-20)15-12-20)21-18-9-5-4-8-17(18)16-6-2-1-3-7-16/h1-9H,10-15H2,(H,21,23)
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n/an/a 6n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50344288
PNG
((R)-3-(benzyl(phenyl)carbamoyloxy)-1-(3-(thiophen-...)
Show SMILES O=C(O[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)N(Cc1ccccc1)c1ccccc1 |r,wD:3.2,(.46,-25.61,;.46,-27.15,;1.8,-27.92,;3.13,-27.15,;4.46,-27.93,;5.79,-27.17,;7.12,-27.93,;8.45,-27.16,;9.78,-27.93,;11.12,-27.16,;11.28,-25.62,;12.78,-25.3,;13.55,-26.63,;12.52,-27.78,;5.8,-25.63,;4.47,-24.85,;3.12,-25.62,;3.88,-26.94,;5.01,-25.82,;-.87,-27.92,;-.87,-29.46,;-2.2,-30.23,;-3.54,-29.45,;-4.87,-30.22,;-4.87,-31.76,;-3.53,-32.53,;-2.2,-31.76,;-2.2,-27.15,;-2.2,-25.61,;-3.53,-24.84,;-4.86,-25.61,;-4.86,-27.16,;-3.53,-27.92,)|
Show InChI InChI=1S/C28H33N2O2S/c31-28(29(25-11-5-2-6-12-25)21-23-9-3-1-4-10-23)32-27-22-30(18-15-24(27)16-19-30)17-7-13-26-14-8-20-33-26/h1-6,8-12,14,20,24,27H,7,13,15-19,21-22H2/q+1/t24?,27-,30?/m0/s1
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n/an/a 7.60n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50344280
PNG
((R)-quinuclidin-3-yl benzyl(4-fluorophenyl)carbama...)
Show SMILES Fc1ccc(cc1)N(Cc1ccccc1)C(=O)O[C@H]1CN2CCC1CC2 |r,wD:18.19,(3.95,-40.95,;5.29,-41.72,;6.62,-40.95,;7.95,-41.72,;7.95,-43.26,;6.62,-44.03,;5.29,-43.27,;9.28,-44.03,;9.28,-45.57,;7.95,-46.34,;6.61,-45.56,;5.28,-46.33,;5.28,-47.87,;6.62,-48.64,;7.95,-47.87,;10.61,-43.26,;10.61,-41.72,;11.95,-44.03,;13.28,-43.26,;14.61,-44.04,;15.94,-43.27,;15.95,-41.73,;14.62,-40.96,;13.27,-41.73,;14.03,-43.05,;15.16,-41.93,)|
Show InChI InChI=1S/C21H23FN2O2/c22-18-6-8-19(9-7-18)24(14-16-4-2-1-3-5-16)21(25)26-20-15-23-12-10-17(20)11-13-23/h1-9,17,20H,10-15H2/t20-/m0/s1
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n/an/a 8.30n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50344293
PNG
((R)-3-(phenyl(thiophen-3-ylmethyl)carbamoyloxy)-1-...)
Show SMILES O=C(O[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)N(Cc1ccsc1)c1ccccc1 |r,wD:3.2,(21.62,.98,;21.62,-.56,;22.95,-1.33,;24.29,-.56,;25.62,-1.34,;26.95,-.57,;28.27,-1.34,;29.61,-.57,;30.94,-1.34,;32.27,-.57,;32.43,.97,;33.93,1.29,;34.71,-.05,;33.68,-1.19,;26.95,.97,;25.62,1.74,;24.28,.97,;25.04,-.35,;26.16,.77,;20.28,-1.33,;20.28,-2.87,;18.95,-3.64,;17.55,-3.02,;16.52,-4.16,;17.29,-5.49,;18.79,-5.17,;18.95,-.56,;18.96,.98,;17.63,1.75,;16.29,.98,;16.3,-.57,;17.63,-1.33,)|
Show InChI InChI=1S/C26H31N2O2S2/c29-26(27(18-21-12-17-31-20-21)23-6-2-1-3-7-23)30-25-19-28(14-10-22(25)11-15-28)13-4-8-24-9-5-16-32-24/h1-3,5-7,9,12,16-17,20,22,25H,4,8,10-11,13-15,18-19H2/q+1/t22?,25-,28?/m0/s1
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n/an/a 8.40n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50344276
PNG
((R)-quinuclidin-3-yl benzyl(thiophen-2-ylmethyl)ca...)
Show SMILES O=C(O[C@H]1CN2CCC1CC2)N(Cc1cccs1)Cc1ccccc1 |r,wD:3.2,(-3.57,-30.09,;-3.57,-31.63,;-2.23,-32.4,;-.9,-31.63,;.43,-32.41,;1.76,-31.65,;1.77,-30.11,;.44,-29.33,;-.9,-30.1,;-.15,-31.42,;.98,-30.3,;-4.9,-32.4,;-6.23,-31.63,;-7.57,-32.4,;-8.99,-31.78,;-10.02,-32.92,;-9.25,-34.26,;-7.74,-33.94,;-4.9,-33.94,;-3.57,-34.71,;-3.58,-36.25,;-2.24,-37.02,;-.91,-36.25,;-.91,-34.71,;-2.25,-33.94,)|
Show InChI InChI=1S/C20H24N2O2S/c23-20(24-19-15-21-10-8-17(19)9-11-21)22(14-18-7-4-12-25-18)13-16-5-2-1-3-6-16/h1-7,12,17,19H,8-11,13-15H2/t19-/m0/s1
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n/an/a 8.80n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50344298
PNG
((R)-3-(butyl(phenyl)carbamoyloxy)-1-(2-phenoxyethy...)
Show SMILES CCCCN(C(=O)O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)c1ccccc1 |r,wD:8.7,(-5.8,-41.35,;-4.46,-40.58,;-3.13,-41.35,;-1.8,-40.58,;-1.8,-39.04,;-.46,-38.27,;-.46,-36.73,;.87,-39.04,;2.2,-38.27,;3.54,-39.05,;4.87,-38.29,;6.19,-39.05,;7.52,-38.28,;8.86,-39.05,;10.19,-38.28,;11.52,-39.05,;12.85,-38.28,;12.85,-36.74,;11.51,-35.97,;10.18,-36.75,;4.87,-36.75,;3.54,-35.97,;2.2,-36.74,;2.96,-38.06,;4.08,-36.94,;-3.13,-38.27,;-3.12,-36.73,;-4.45,-35.96,;-5.79,-36.73,;-5.78,-38.28,;-4.45,-39.04,)|
Show InChI InChI=1S/C26H35N2O3/c1-2-3-16-27(23-10-6-4-7-11-23)26(29)31-25-21-28(17-14-22(25)15-18-28)19-20-30-24-12-8-5-9-13-24/h4-13,22,25H,2-3,14-21H2,1H3/q+1/t22?,25-,28?/m0/s1
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n/an/a 8.90n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50344290
PNG
((R)-1-methyl-3-(phenyl(thiophen-2-ylmethyl)carbamo...)
Show SMILES C[N+]12CCC(CC1)[C@H](C2)OC(=O)N(Cc1cccs1)c1ccccc1 |r|
Show InChI InChI=1S/C20H25N2O2S.BrH/c1-22-11-9-16(10-12-22)19(15-22)24-20(23)21(14-18-8-5-13-25-18)17-6-3-2-4-7-17;/h2-8,13,16,19H,9-12,14-15H2,1H3;1H/q+1;/p-1/t16?,19-,22?;/m0./s1
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n/an/a 9.20n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50344297
PNG
((R)-3-(butyl(phenyl)carbamoyloxy)-1-(3-(thiophen-2...)
Show SMILES CCCCN(C(=O)O[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)c1ccccc1 |r,wD:8.7,(18.41,-29.52,;19.75,-28.75,;21.08,-29.52,;22.42,-28.75,;22.42,-27.21,;23.75,-26.44,;23.75,-24.9,;25.08,-27.21,;26.42,-26.44,;27.75,-27.21,;29.08,-26.45,;30.4,-27.21,;31.74,-26.44,;33.07,-27.21,;34.4,-26.44,;34.56,-24.9,;36.07,-24.58,;36.84,-25.91,;35.81,-27.06,;29.09,-24.91,;27.75,-24.14,;26.41,-24.9,;27.17,-26.23,;28.3,-25.11,;21.08,-26.44,;21.09,-24.89,;19.76,-24.12,;18.42,-24.89,;18.43,-26.44,;19.76,-27.21,)|
Show InChI InChI=1S/C25H35N2O2S/c1-2-3-15-26(22-9-5-4-6-10-22)25(28)29-24-20-27(17-13-21(24)14-18-27)16-7-11-23-12-8-19-30-23/h4-6,8-10,12,19,21,24H,2-3,7,11,13-18,20H2,1H3/q+1/t21?,24-,27?/m0/s1
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n/an/a 10.9n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50344274
PNG
((R)-quinuclidin-3-yl pentyl(phenyl)carbamate | CHE...)
Show SMILES CCCCCN(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1 |r,wD:9.8,(12.29,-26.84,;12.29,-25.3,;10.95,-24.53,;10.95,-22.99,;9.62,-22.22,;9.62,-20.68,;10.95,-19.91,;10.95,-18.37,;12.29,-20.68,;13.62,-19.91,;14.95,-20.69,;16.28,-19.92,;16.29,-18.38,;14.96,-17.61,;13.62,-18.38,;14.37,-19.7,;15.5,-18.58,;8.29,-19.91,;8.3,-18.37,;6.96,-17.6,;5.63,-18.37,;5.63,-19.92,;6.97,-20.68,)|
Show InChI InChI=1S/C19H28N2O2/c1-2-3-7-12-21(17-8-5-4-6-9-17)19(22)23-18-15-20-13-10-16(18)11-14-20/h4-6,8-9,16,18H,2-3,7,10-15H2,1H3/t18-/m0/s1
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n/an/a 13.6n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50344301
PNG
((R)-3-((3-fluorophenyl)(3,4,5-trifluorobenzyl)carb...)
Show SMILES Fc1cccc(c1)N(Cc1cc(F)c(F)c(F)c1)C(=O)O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2 |r,wD:21.22,(-3.92,-9.63,;-3.92,-11.17,;-5.25,-11.94,;-5.25,-13.49,;-3.91,-14.25,;-2.59,-13.48,;-2.58,-11.94,;-1.26,-14.25,;-1.26,-15.79,;-2.59,-16.56,;-3.92,-15.78,;-5.26,-16.55,;-6.59,-15.78,;-5.26,-18.09,;-6.59,-18.86,;-3.91,-18.86,;-3.91,-20.4,;-2.59,-18.09,;.07,-13.48,;.07,-11.94,;1.41,-14.25,;2.74,-13.48,;4.07,-14.26,;5.4,-13.49,;6.73,-14.26,;8.06,-13.49,;9.4,-14.25,;10.73,-13.48,;12.06,-14.26,;13.39,-13.49,;13.39,-11.95,;12.04,-11.18,;10.72,-11.95,;5.41,-11.95,;4.08,-11.18,;2.74,-11.94,;3.49,-13.27,;4.62,-12.15,)|
Show InChI InChI=1S/C29H29F4N2O3/c30-22-5-4-6-23(17-22)34(18-20-15-25(31)28(33)26(32)16-20)29(36)38-27-19-35(11-9-21(27)10-12-35)13-14-37-24-7-2-1-3-8-24/h1-8,15-17,21,27H,9-14,18-19H2/q+1/t21?,27-,35?/m0/s1
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n/an/a 14.4n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50344285
PNG
(CHEMBL1779047 | quinuclidin-4-yl biphenyl-2-ylcarb...)
Show SMILES O=C(Nc1ccccc1-c1ccccc1)OC12CCN(CC1)CC2
Show InChI InChI=1S/C20H22N2O2/c23-19(24-20-10-13-22(14-11-20)15-12-20)21-18-9-5-4-8-17(18)16-6-2-1-3-7-16/h1-9H,10-15H2,(H,21,23)
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n/an/a 14.5n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))		BDBM50344280
PNG
((R)-quinuclidin-3-yl benzyl(4-fluorophenyl)carbama...)
Show SMILES Fc1ccc(cc1)N(Cc1ccccc1)C(=O)O[C@H]1CN2CCC1CC2 |r,wD:18.19,(3.95,-40.95,;5.29,-41.72,;6.62,-40.95,;7.95,-41.72,;7.95,-43.26,;6.62,-44.03,;5.29,-43.27,;9.28,-44.03,;9.28,-45.57,;7.95,-46.34,;6.61,-45.56,;5.28,-46.33,;5.28,-47.87,;6.62,-48.64,;7.95,-47.87,;10.61,-43.26,;10.61,-41.72,;11.95,-44.03,;13.28,-43.26,;14.61,-44.04,;15.94,-43.27,;15.95,-41.73,;14.62,-40.96,;13.27,-41.73,;14.03,-43.05,;15.16,-41.93,)|
Show InChI InChI=1S/C21H23FN2O2/c22-18-6-8-19(9-7-18)24(14-16-4-2-1-3-5-16)21(25)26-20-15-23-12-10-17(20)11-13-23/h1-9,17,20H,10-15H2/t20-/m0/s1
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n/an/a 15n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50344286
PNG
((R)-3-(benzyl(phenyl)carbamoyloxy)-1-phenethyl-1-a...)
Show SMILES O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)N(Cc1ccccc1)c1ccccc1 |r,wD:3.2,(-.95,-13.02,;-.95,-14.56,;.39,-15.33,;1.72,-14.56,;3.05,-15.34,;4.38,-14.57,;5.71,-15.34,;7.04,-14.57,;8.38,-15.34,;8.37,-16.87,;9.71,-17.64,;11.04,-16.87,;11.03,-15.32,;9.7,-14.56,;4.39,-13.03,;3.06,-12.26,;1.72,-13.03,;2.47,-14.35,;3.6,-13.23,;-2.28,-15.33,;-2.28,-16.87,;-3.61,-17.64,;-4.94,-16.86,;-6.28,-17.63,;-6.28,-19.17,;-4.93,-19.94,;-3.61,-19.17,;-3.61,-14.56,;-3.6,-13.02,;-4.94,-12.25,;-6.27,-13.02,;-6.27,-14.57,;-4.93,-15.33,)|
Show InChI InChI=1S/C29H33N2O2/c32-29(30(27-14-8-3-9-15-27)22-25-12-6-2-7-13-25)33-28-23-31(20-17-26(28)18-21-31)19-16-24-10-4-1-5-11-24/h1-15,26,28H,16-23H2/q+1/t26?,28-,31?/m0/s1
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n/an/a 15.1n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50344296
PNG
((R)-3-(butyl(phenyl)carbamoyloxy)-1-(3-phenylpropy...)
Show SMILES CCCCN(C(=O)O[C@H]1C[N+]2(CCCc3ccccc3)CCC1CC2)c1ccccc1 |r,wD:8.7,(-3.06,-29.35,;-1.73,-28.58,;-.39,-29.35,;.94,-28.58,;.94,-27.04,;2.27,-26.27,;2.27,-24.73,;3.61,-27.04,;4.94,-26.27,;6.27,-27.05,;7.6,-26.29,;8.93,-27.05,;10.26,-26.28,;11.6,-27.05,;12.93,-26.28,;14.26,-27.05,;15.59,-26.28,;15.59,-24.74,;14.25,-23.97,;12.92,-24.75,;7.61,-24.75,;6.28,-23.97,;4.94,-24.74,;5.69,-26.06,;6.82,-24.94,;-.39,-26.27,;-.38,-24.73,;-1.72,-23.96,;-3.05,-24.73,;-3.05,-26.28,;-1.71,-27.04,)|
Show InChI InChI=1S/C27H37N2O2/c1-2-3-18-28(25-14-8-5-9-15-25)27(30)31-26-22-29(20-16-24(26)17-21-29)19-10-13-23-11-6-4-7-12-23/h4-9,11-12,14-15,24,26H,2-3,10,13,16-22H2,1H3/q+1/t24?,26-,29?/m0/s1
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n/an/a 17.7n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))		BDBM50344278
PNG
((R)-quinuclidin-3-yl butyl(thiophen-2-ylmethyl)car...)
Show SMILES CCCCN(Cc1cccs1)C(=O)O[C@H]1CN2CCC1CC2 |r,wD:14.14,(21.3,-35.16,;22.63,-34.39,;23.97,-35.16,;25.3,-34.39,;25.3,-32.85,;23.97,-32.08,;23.97,-30.54,;25.2,-29.63,;24.73,-28.16,;23.19,-28.16,;22.71,-29.63,;26.63,-32.08,;26.63,-30.54,;27.97,-32.85,;29.3,-32.08,;30.63,-32.85,;31.96,-32.09,;31.97,-30.55,;30.64,-29.77,;29.3,-30.54,;30.05,-31.87,;31.18,-30.75,)|
Show InChI InChI=1S/C17H26N2O2S/c1-2-3-8-19(12-15-5-4-11-22-15)17(20)21-16-13-18-9-6-14(16)7-10-18/h4-5,11,14,16H,2-3,6-10,12-13H2,1H3/t16-/m0/s1
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n/an/a 17.7n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))		BDBM50344286
PNG
((R)-3-(benzyl(phenyl)carbamoyloxy)-1-phenethyl-1-a...)
Show SMILES O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)N(Cc1ccccc1)c1ccccc1 |r,wD:3.2,(-.95,-13.02,;-.95,-14.56,;.39,-15.33,;1.72,-14.56,;3.05,-15.34,;4.38,-14.57,;5.71,-15.34,;7.04,-14.57,;8.38,-15.34,;8.37,-16.87,;9.71,-17.64,;11.04,-16.87,;11.03,-15.32,;9.7,-14.56,;4.39,-13.03,;3.06,-12.26,;1.72,-13.03,;2.47,-14.35,;3.6,-13.23,;-2.28,-15.33,;-2.28,-16.87,;-3.61,-17.64,;-4.94,-16.86,;-6.28,-17.63,;-6.28,-19.17,;-4.93,-19.94,;-3.61,-19.17,;-3.61,-14.56,;-3.6,-13.02,;-4.94,-12.25,;-6.27,-13.02,;-6.27,-14.57,;-4.93,-15.33,)|
Show InChI InChI=1S/C29H33N2O2/c32-29(30(27-14-8-3-9-15-27)22-25-12-6-2-7-13-25)33-28-23-31(20-17-26(28)18-21-31)19-16-24-10-4-1-5-11-24/h1-15,26,28H,16-23H2/q+1/t26?,28-,31?/m0/s1
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n/an/a 17.7n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))		BDBM50344290
PNG
((R)-1-methyl-3-(phenyl(thiophen-2-ylmethyl)carbamo...)
Show SMILES C[N+]12CCC(CC1)[C@H](C2)OC(=O)N(Cc1cccs1)c1ccccc1 |r|
Show InChI InChI=1S/C20H25N2O2S.BrH/c1-22-11-9-16(10-12-22)19(15-22)24-20(23)21(14-18-8-5-13-25-18)17-6-3-2-4-7-17;/h2-8,13,16,19H,9-12,14-15H2,1H3;1H/q+1;/p-1/t16?,19-,22?;/m0./s1
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n/an/a 18.6n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))		BDBM50344295
PNG
((R)-3-(butyl(phenyl)carbamoyloxy)-1-phenethyl-1-az...)
Show SMILES CCCCN(C(=O)O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)c1ccccc1 |r,wD:8.7,(18.9,-16.34,;20.24,-15.57,;21.57,-16.34,;22.91,-15.57,;22.91,-14.03,;24.24,-13.26,;24.24,-11.72,;25.57,-14.03,;26.91,-13.26,;28.24,-14.04,;29.57,-13.27,;30.89,-14.04,;32.23,-13.27,;33.56,-14.04,;33.56,-15.57,;34.89,-16.34,;36.22,-15.57,;36.22,-14.02,;34.88,-13.26,;29.58,-11.73,;28.24,-10.96,;26.9,-11.73,;27.66,-13.05,;28.79,-11.93,;21.57,-13.26,;21.58,-11.72,;20.25,-10.95,;18.91,-11.72,;18.92,-13.27,;20.25,-14.03,)|
Show InChI InChI=1S/C26H35N2O2/c1-2-3-17-27(24-12-8-5-9-13-24)26(29)30-25-21-28(19-15-23(25)16-20-28)18-14-22-10-6-4-7-11-22/h4-13,23,25H,2-3,14-21H2,1H3/q+1/t23?,25-,28?/m0/s1
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n/an/a 19n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))		BDBM50344276
PNG
((R)-quinuclidin-3-yl benzyl(thiophen-2-ylmethyl)ca...)
Show SMILES O=C(O[C@H]1CN2CCC1CC2)N(Cc1cccs1)Cc1ccccc1 |r,wD:3.2,(-3.57,-30.09,;-3.57,-31.63,;-2.23,-32.4,;-.9,-31.63,;.43,-32.41,;1.76,-31.65,;1.77,-30.11,;.44,-29.33,;-.9,-30.1,;-.15,-31.42,;.98,-30.3,;-4.9,-32.4,;-6.23,-31.63,;-7.57,-32.4,;-8.99,-31.78,;-10.02,-32.92,;-9.25,-34.26,;-7.74,-33.94,;-4.9,-33.94,;-3.57,-34.71,;-3.58,-36.25,;-2.24,-37.02,;-.91,-36.25,;-.91,-34.71,;-2.25,-33.94,)|
Show InChI InChI=1S/C20H24N2O2S/c23-20(24-19-15-21-10-8-17(19)9-11-21)22(14-18-7-4-12-25-18)13-16-5-2-1-3-6-16/h1-7,12,17,19H,8-11,13-15H2/t19-/m0/s1
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n/an/a 22.5n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50344277
PNG
((R)-quinuclidin-3-yl bis(thiophen-2-ylmethyl)carba...)
Show SMILES O=C(O[C@H]1CN2CCC1CC2)N(Cc1cccs1)Cc1cccs1 |r,wD:3.2,(10.96,-30.88,;10.96,-32.42,;12.3,-33.19,;13.63,-32.42,;14.96,-33.19,;16.29,-32.43,;16.3,-30.89,;14.97,-30.12,;13.62,-30.88,;14.38,-32.21,;15.51,-31.09,;9.63,-33.19,;8.3,-32.42,;8.3,-30.88,;9.53,-29.97,;9.06,-28.5,;7.52,-28.5,;7.04,-29.97,;9.63,-34.73,;8.3,-35.5,;6.89,-34.88,;5.86,-36.03,;6.63,-37.36,;8.13,-37.04,)|
Show InChI InChI=1S/C18H22N2O2S2/c21-18(22-17-13-19-7-5-14(17)6-8-19)20(11-15-3-1-9-23-15)12-16-4-2-10-24-16/h1-4,9-10,14,17H,5-8,11-13H2/t17-/m0/s1
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n/an/a 22.7n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50344273
PNG
((R)-quinuclidin-3-yl butyl(phenyl)carbamate | CHEM...)
Show SMILES CCCCN(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1 |r,wD:8.7,(-8.01,-25.61,;-6.68,-24.84,;-6.68,-23.3,;-5.34,-22.53,;-5.34,-20.99,;-4.01,-20.22,;-4.01,-18.68,;-2.68,-20.99,;-1.34,-20.22,;-.01,-21,;1.32,-20.24,;1.33,-18.7,;-.01,-17.92,;-1.35,-18.69,;-.59,-20.01,;.54,-18.89,;-6.68,-20.22,;-6.67,-18.68,;-8,-17.91,;-9.34,-18.68,;-9.33,-20.23,;-8,-20.99,)|
Show InChI InChI=1S/C18H26N2O2/c1-2-3-11-20(16-7-5-4-6-8-16)18(21)22-17-14-19-12-9-15(17)10-13-19/h4-8,15,17H,2-3,9-14H2,1H3/t17-/m0/s1
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n/an/a 22.9n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50344272
PNG
((R)-quinuclidin-3-yl phenyl(propyl)carbamate | CHE...)
Show SMILES CCCN(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1 |r,wD:7.6,(23.62,-14.44,;23.62,-12.9,;24.95,-12.13,;24.95,-10.59,;26.28,-9.82,;26.28,-8.28,;27.62,-10.59,;28.95,-9.82,;30.28,-10.59,;31.61,-9.83,;31.62,-8.29,;30.29,-7.51,;28.95,-8.28,;29.7,-9.61,;30.83,-8.49,;23.62,-9.82,;23.63,-8.27,;22.29,-7.5,;20.96,-8.27,;20.96,-9.82,;22.3,-10.58,)|
Show InChI InChI=1S/C17H24N2O2/c1-2-10-19(15-6-4-3-5-7-15)17(20)21-16-13-18-11-8-14(16)9-12-18/h3-7,14,16H,2,8-13H2,1H3/t16-/m0/s1
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n/an/a 26.7n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50344281
PNG
((R)-quinuclidin-3-yl 3-fluorobenzyl(3-fluorophenyl...)
Show SMILES Fc1cccc(CN(C(=O)O[C@H]2CN3CCC2CC3)c2cccc(F)c2)c1 |r,wD:11.10,(23.52,-50.24,;23.52,-48.7,;22.17,-47.93,;22.18,-46.38,;23.51,-45.62,;24.84,-46.39,;26.17,-45.62,;26.17,-44.08,;27.51,-43.31,;27.51,-41.77,;28.84,-44.08,;30.17,-43.31,;31.5,-44.09,;32.83,-43.33,;32.84,-41.79,;31.51,-41.01,;30.17,-41.78,;30.92,-43.1,;32.05,-41.98,;24.84,-43.31,;23.52,-44.08,;22.19,-43.32,;22.18,-41.77,;23.52,-41,;23.52,-39.46,;24.85,-41.77,;24.84,-47.92,)|
Show InChI InChI=1S/C21H22F2N2O2/c22-17-4-1-3-15(11-17)13-25(19-6-2-5-18(23)12-19)21(26)27-20-14-24-9-7-16(20)8-10-24/h1-6,11-12,16,20H,7-10,13-14H2/t20-/m0/s1
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n/an/a 26.8n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50344300
PNG
((R)-1-(2-phenoxyethyl)-3-(m-tolyl(2,4,5-trifluorob...)
Show SMILES Cc1cccc(c1)N(Cc1cc(F)c(F)cc1F)C(=O)O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2 |r,wD:21.22,(19.44,3.82,;19.44,2.28,;18.1,1.51,;18.11,-.04,;19.44,-.8,;20.76,-.03,;20.77,1.51,;22.1,-.8,;22.1,-2.34,;20.76,-3.11,;19.43,-2.33,;18.1,-3.1,;16.77,-2.33,;18.1,-4.64,;16.77,-5.41,;19.44,-5.41,;20.77,-4.64,;22.11,-5.4,;23.43,-.03,;23.43,1.51,;24.76,-.8,;26.1,-.03,;27.43,-.81,;28.76,-.04,;30.08,-.81,;31.42,-.04,;32.75,-.81,;34.08,-.04,;35.41,-.81,;36.74,-.04,;36.74,1.5,;35.4,2.27,;34.07,1.5,;28.77,1.5,;27.43,2.27,;26.09,1.5,;26.85,.18,;27.98,1.3,)|
Show InChI InChI=1S/C30H32F3N2O3/c1-21-6-5-7-24(16-21)34(19-23-17-27(32)28(33)18-26(23)31)30(36)38-29-20-35(12-10-22(29)11-13-35)14-15-37-25-8-3-2-4-9-25/h2-9,16-18,22,29H,10-15,19-20H2,1H3/q+1/t22?,29-,35?/m0/s1
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n/an/a 28n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50344299
PNG
((R)-1-(3-phenylpropyl)-3-(m-tolyl(2,4,5-trifluorob...)
Show SMILES Cc1cccc(c1)N(Cc1cc(F)c(F)cc1F)C(=O)O[C@H]1C[N+]2(CCCc3ccccc3)CCC1CC2 |r,wD:21.22,(-4.97,4.35,;-4.97,2.81,;-6.31,2.04,;-6.3,.49,;-4.97,-.27,;-3.65,.5,;-3.64,2.04,;-2.32,-.27,;-2.32,-1.81,;-3.65,-2.58,;-4.98,-1.8,;-6.31,-2.57,;-7.65,-1.8,;-6.32,-4.11,;-7.65,-4.89,;-4.97,-4.88,;-3.65,-4.11,;-2.31,-4.87,;-.98,.5,;-.98,2.04,;.35,-.27,;1.68,.5,;3.01,-.28,;4.34,.48,;5.67,-.28,;7,.49,;8.34,-.28,;9.67,.49,;11,-.28,;12.33,.49,;12.33,2.03,;10.99,2.8,;9.66,2.02,;4.35,2.02,;3.02,2.8,;1.68,2.03,;2.43,.71,;3.56,1.83,)|
Show InChI InChI=1S/C31H34F3N2O2/c1-22-7-5-11-26(17-22)35(20-25-18-28(33)29(34)19-27(25)32)31(37)38-30-21-36(15-12-24(30)13-16-36)14-6-10-23-8-3-2-4-9-23/h2-5,7-9,11,17-19,24,30H,6,10,12-16,20-21H2,1H3/q+1/t24?,30-,36?/m0/s1
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n/an/a 29.8n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50344290
PNG
((R)-1-methyl-3-(phenyl(thiophen-2-ylmethyl)carbamo...)
Show SMILES C[N+]12CCC(CC1)[C@H](C2)OC(=O)N(Cc1cccs1)c1ccccc1 |r|
Show InChI InChI=1S/C20H25N2O2S.BrH/c1-22-11-9-16(10-12-22)19(15-22)24-20(23)21(14-18-8-5-13-25-18)17-6-3-2-4-7-17;/h2-8,13,16,19H,9-12,14-15H2,1H3;1H/q+1;/p-1/t16?,19-,22?;/m0./s1
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n/an/a 33.1n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50344295
PNG
((R)-3-(butyl(phenyl)carbamoyloxy)-1-phenethyl-1-az...)
Show SMILES CCCCN(C(=O)O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)c1ccccc1 |r,wD:8.7,(18.9,-16.34,;20.24,-15.57,;21.57,-16.34,;22.91,-15.57,;22.91,-14.03,;24.24,-13.26,;24.24,-11.72,;25.57,-14.03,;26.91,-13.26,;28.24,-14.04,;29.57,-13.27,;30.89,-14.04,;32.23,-13.27,;33.56,-14.04,;33.56,-15.57,;34.89,-16.34,;36.22,-15.57,;36.22,-14.02,;34.88,-13.26,;29.58,-11.73,;28.24,-10.96,;26.9,-11.73,;27.66,-13.05,;28.79,-11.93,;21.57,-13.26,;21.58,-11.72,;20.25,-10.95,;18.91,-11.72,;18.92,-13.27,;20.25,-14.03,)|
Show InChI InChI=1S/C26H35N2O2/c1-2-3-17-27(24-12-8-5-9-13-24)26(29)30-25-21-28(19-15-23(25)16-20-28)18-14-22-10-6-4-7-11-22/h4-13,23,25H,2-3,14-21H2,1H3/q+1/t23?,25-,28?/m0/s1
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n/an/a 33.3n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50344279
PNG
((R)-quinuclidin-3-yl benzyl(p-tolyl)carbamate | CH...)
Show SMILES Cc1ccc(cc1)N(Cc1ccccc1)C(=O)O[C@H]1CN2CCC1CC2 |r,wD:18.19,(-10.57,-40.15,;-9.24,-40.92,;-9.23,-42.47,;-7.9,-43.23,;-6.58,-42.46,;-6.57,-40.92,;-7.91,-40.15,;-5.25,-43.23,;-5.25,-44.77,;-3.92,-45.54,;-3.92,-47.08,;-2.59,-47.85,;-1.26,-47.08,;-1.26,-45.53,;-2.59,-44.77,;-3.92,-42.46,;-3.92,-40.92,;-2.58,-43.23,;-1.25,-42.46,;.08,-43.24,;1.41,-42.47,;1.42,-40.93,;.09,-40.16,;-1.25,-40.93,;-.5,-42.25,;.63,-41.13,)|
Show InChI InChI=1S/C22H26N2O2/c1-17-7-9-20(10-8-17)24(15-18-5-3-2-4-6-18)22(25)26-21-16-23-13-11-19(21)12-14-23/h2-10,19,21H,11-16H2,1H3/t21-/m0/s1
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n/an/a 39.7n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50344269
PNG
((R)-quinuclidin-3-yl phenethyl(phenyl)carbamate | ...)
Show SMILES O=C(O[C@H]1CN2CCC1CC2)N(CCc1ccccc1)c1ccccc1 |r,wD:3.2,(25.48,4.31,;25.48,2.77,;26.82,2,;28.15,2.77,;29.48,1.99,;30.81,2.76,;30.82,4.3,;29.49,5.07,;28.15,4.3,;28.9,2.98,;30.03,4.1,;24.15,2,;24.15,.46,;22.82,-.31,;22.82,-1.85,;21.48,-2.61,;21.48,-4.15,;22.81,-4.92,;24.15,-4.15,;24.14,-2.61,;22.82,2.77,;22.83,4.31,;21.49,5.08,;20.16,4.31,;20.16,2.76,;21.5,2,)|
Show InChI InChI=1S/C22H26N2O2/c25-22(26-21-17-23-14-12-19(21)13-15-23)24(20-9-5-2-6-10-20)16-11-18-7-3-1-4-8-18/h1-10,19,21H,11-17H2/t21-/m0/s1
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n/an/a 42.1n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50344282
PNG
((R)-quinuclidin-3-yl m-tolyl(2,4,5-trifluorobenzyl...)
Show SMILES Cc1cccc(c1)N(Cc1cc(F)c(F)cc1F)C(=O)O[C@H]1CN2CCC1CC2 |r,wD:21.22,(-3.76,3.63,;-3.76,2.09,;-5.1,1.32,;-5.09,-.22,;-3.76,-.99,;-2.43,-.22,;-2.43,1.32,;-1.1,-.99,;-1.1,-2.53,;-2.43,-3.3,;-3.77,-2.53,;-5.1,-3.29,;-6.43,-2.52,;-5.1,-4.84,;-6.43,-5.61,;-3.76,-5.61,;-2.43,-4.83,;-1.09,-5.6,;.24,-.22,;.24,1.32,;1.57,-.99,;2.9,-.22,;4.24,-.99,;5.57,-.23,;5.57,1.31,;4.24,2.08,;2.9,1.32,;3.66,-.01,;4.78,1.11,)|
Show InChI InChI=1S/C22H23F3N2O2/c1-14-3-2-4-17(9-14)27(12-16-10-19(24)20(25)11-18(16)23)22(28)29-21-13-26-7-5-15(21)6-8-26/h2-4,9-11,15,21H,5-8,12-13H2,1H3/t21-/m0/s1
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n/an/a 45.8n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50344286
PNG
((R)-3-(benzyl(phenyl)carbamoyloxy)-1-phenethyl-1-a...)
Show SMILES O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)N(Cc1ccccc1)c1ccccc1 |r,wD:3.2,(-.95,-13.02,;-.95,-14.56,;.39,-15.33,;1.72,-14.56,;3.05,-15.34,;4.38,-14.57,;5.71,-15.34,;7.04,-14.57,;8.38,-15.34,;8.37,-16.87,;9.71,-17.64,;11.04,-16.87,;11.03,-15.32,;9.7,-14.56,;4.39,-13.03,;3.06,-12.26,;1.72,-13.03,;2.47,-14.35,;3.6,-13.23,;-2.28,-15.33,;-2.28,-16.87,;-3.61,-17.64,;-4.94,-16.86,;-6.28,-17.63,;-6.28,-19.17,;-4.93,-19.94,;-3.61,-19.17,;-3.61,-14.56,;-3.6,-13.02,;-4.94,-12.25,;-6.27,-13.02,;-6.27,-14.57,;-4.93,-15.33,)|
Show InChI InChI=1S/C29H33N2O2/c32-29(30(27-14-8-3-9-15-27)22-25-12-6-2-7-13-25)33-28-23-31(20-17-26(28)18-21-31)19-16-24-10-4-1-5-11-24/h1-15,26,28H,16-23H2/q+1/t26?,28-,31?/m0/s1
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n/an/a 50.9n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50344284
PNG
(CHEMBL1200803 | Solifenacin | Solifenacin succinat...)
Show SMILES O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2[C@@H]1c1ccccc1 |r,wD:3.2,20.24,THB:2:3:9.10:7.6,(12.11,-12.08,;13.44,-12.86,;14.78,-12.1,;14.78,-10.57,;14.5,-9.18,;13.16,-8.57,;13.23,-6.92,;13.67,-8.04,;13.42,-9.94,;11.89,-10.59,;11.69,-9.21,;13.43,-14.39,;14.77,-15.19,;14.73,-16.74,;13.38,-17.48,;13.37,-19.02,;12.02,-19.77,;10.7,-18.97,;10.72,-17.43,;12.06,-16.69,;12.08,-15.14,;10.76,-14.35,;9.42,-15.1,;8.1,-14.31,;8.13,-12.76,;9.47,-12.02,;10.79,-12.81,)|
Show InChI InChI=1S/C23H26N2O2/c26-23(27-21-16-24-13-10-18(21)11-14-24)25-15-12-17-6-4-5-9-20(17)22(25)19-7-2-1-3-8-19/h1-9,18,21-22H,10-16H2/t21-,22-/m0/s1
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n/an/a 63.5n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))		BDBM50344272
PNG
((R)-quinuclidin-3-yl phenyl(propyl)carbamate | CHE...)
Show SMILES CCCN(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1 |r,wD:7.6,(23.62,-14.44,;23.62,-12.9,;24.95,-12.13,;24.95,-10.59,;26.28,-9.82,;26.28,-8.28,;27.62,-10.59,;28.95,-9.82,;30.28,-10.59,;31.61,-9.83,;31.62,-8.29,;30.29,-7.51,;28.95,-8.28,;29.7,-9.61,;30.83,-8.49,;23.62,-9.82,;23.63,-8.27,;22.29,-7.5,;20.96,-8.27,;20.96,-9.82,;22.3,-10.58,)|
Show InChI InChI=1S/C17H24N2O2/c1-2-10-19(15-6-4-3-5-7-15)17(20)21-16-13-18-11-8-14(16)9-12-18/h3-7,14,16H,2,8-13H2,1H3/t16-/m0/s1
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n/an/a 71.1n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))		BDBM50344279
PNG
((R)-quinuclidin-3-yl benzyl(p-tolyl)carbamate | CH...)
Show SMILES Cc1ccc(cc1)N(Cc1ccccc1)C(=O)O[C@H]1CN2CCC1CC2 |r,wD:18.19,(-10.57,-40.15,;-9.24,-40.92,;-9.23,-42.47,;-7.9,-43.23,;-6.58,-42.46,;-6.57,-40.92,;-7.91,-40.15,;-5.25,-43.23,;-5.25,-44.77,;-3.92,-45.54,;-3.92,-47.08,;-2.59,-47.85,;-1.26,-47.08,;-1.26,-45.53,;-2.59,-44.77,;-3.92,-42.46,;-3.92,-40.92,;-2.58,-43.23,;-1.25,-42.46,;.08,-43.24,;1.41,-42.47,;1.42,-40.93,;.09,-40.16,;-1.25,-40.93,;-.5,-42.25,;.63,-41.13,)|
Show InChI InChI=1S/C22H26N2O2/c1-17-7-9-20(10-8-17)24(15-18-5-3-2-4-6-18)22(25)26-21-16-23-13-11-19(21)12-14-23/h2-10,19,21H,11-16H2,1H3/t21-/m0/s1
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n/an/a 74.7n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50344278
PNG
((R)-quinuclidin-3-yl butyl(thiophen-2-ylmethyl)car...)
Show SMILES CCCCN(Cc1cccs1)C(=O)O[C@H]1CN2CCC1CC2 |r,wD:14.14,(21.3,-35.16,;22.63,-34.39,;23.97,-35.16,;25.3,-34.39,;25.3,-32.85,;23.97,-32.08,;23.97,-30.54,;25.2,-29.63,;24.73,-28.16,;23.19,-28.16,;22.71,-29.63,;26.63,-32.08,;26.63,-30.54,;27.97,-32.85,;29.3,-32.08,;30.63,-32.85,;31.96,-32.09,;31.97,-30.55,;30.64,-29.77,;29.3,-30.54,;30.05,-31.87,;31.18,-30.75,)|
Show InChI InChI=1S/C17H26N2O2S/c1-2-3-8-19(12-15-5-4-11-22-15)17(20)21-16-13-18-9-6-14(16)7-10-18/h4-5,11,14,16H,2-3,6-10,12-13H2,1H3/t16-/m0/s1
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n/an/a 76.2n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50344276
PNG
((R)-quinuclidin-3-yl benzyl(thiophen-2-ylmethyl)ca...)
Show SMILES O=C(O[C@H]1CN2CCC1CC2)N(Cc1cccs1)Cc1ccccc1 |r,wD:3.2,(-3.57,-30.09,;-3.57,-31.63,;-2.23,-32.4,;-.9,-31.63,;.43,-32.41,;1.76,-31.65,;1.77,-30.11,;.44,-29.33,;-.9,-30.1,;-.15,-31.42,;.98,-30.3,;-4.9,-32.4,;-6.23,-31.63,;-7.57,-32.4,;-8.99,-31.78,;-10.02,-32.92,;-9.25,-34.26,;-7.74,-33.94,;-4.9,-33.94,;-3.57,-34.71,;-3.58,-36.25,;-2.24,-37.02,;-.91,-36.25,;-.91,-34.71,;-2.25,-33.94,)|
Show InChI InChI=1S/C20H24N2O2S/c23-20(24-19-15-21-10-8-17(19)9-11-21)22(14-18-7-4-12-25-18)13-16-5-2-1-3-6-16/h1-7,12,17,19H,8-11,13-15H2/t19-/m0/s1
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n/an/a 88.9n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50344283
PNG
((R)-quinuclidin-3-yl 3-fluorophenyl(3,4,5-trifluor...)
Show SMILES Fc1cccc(c1)N(Cc1cc(F)c(F)c(F)c1)C(=O)O[C@H]1CN2CCC1CC2 |r,wD:21.22,(13.85,4.33,;13.85,2.79,;12.51,2.02,;12.52,.47,;13.85,-.29,;15.18,.47,;15.18,2.02,;16.51,-.3,;16.51,-1.84,;15.18,-2.61,;13.84,-1.83,;12.51,-2.6,;11.18,-1.83,;12.51,-4.14,;11.18,-4.92,;13.85,-4.91,;13.86,-6.45,;15.18,-4.14,;17.85,.47,;17.85,2.01,;19.18,-.3,;20.51,.47,;21.84,-.3,;23.17,.46,;23.18,2,;21.85,2.78,;20.51,2.01,;21.26,.68,;22.39,1.8,)|
Show InChI InChI=1S/C21H20F4N2O2/c22-15-2-1-3-16(10-15)27(11-13-8-17(23)20(25)18(24)9-13)21(28)29-19-12-26-6-4-14(19)5-7-26/h1-3,8-10,14,19H,4-7,11-12H2/t19-/m0/s1
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n/an/a 97.3n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50344280
PNG
((R)-quinuclidin-3-yl benzyl(4-fluorophenyl)carbama...)
Show SMILES Fc1ccc(cc1)N(Cc1ccccc1)C(=O)O[C@H]1CN2CCC1CC2 |r,wD:18.19,(3.95,-40.95,;5.29,-41.72,;6.62,-40.95,;7.95,-41.72,;7.95,-43.26,;6.62,-44.03,;5.29,-43.27,;9.28,-44.03,;9.28,-45.57,;7.95,-46.34,;6.61,-45.56,;5.28,-46.33,;5.28,-47.87,;6.62,-48.64,;7.95,-47.87,;10.61,-43.26,;10.61,-41.72,;11.95,-44.03,;13.28,-43.26,;14.61,-44.04,;15.94,-43.27,;15.95,-41.73,;14.62,-40.96,;13.27,-41.73,;14.03,-43.05,;15.16,-41.93,)|
Show InChI InChI=1S/C21H23FN2O2/c22-18-6-8-19(9-7-18)24(14-16-4-2-1-3-5-16)21(25)26-20-15-23-12-10-17(20)11-13-23/h1-9,17,20H,10-15H2/t20-/m0/s1
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n/an/a 116n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50344295
PNG
((R)-3-(butyl(phenyl)carbamoyloxy)-1-phenethyl-1-az...)
Show SMILES CCCCN(C(=O)O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)c1ccccc1 |r,wD:8.7,(18.9,-16.34,;20.24,-15.57,;21.57,-16.34,;22.91,-15.57,;22.91,-14.03,;24.24,-13.26,;24.24,-11.72,;25.57,-14.03,;26.91,-13.26,;28.24,-14.04,;29.57,-13.27,;30.89,-14.04,;32.23,-13.27,;33.56,-14.04,;33.56,-15.57,;34.89,-16.34,;36.22,-15.57,;36.22,-14.02,;34.88,-13.26,;29.58,-11.73,;28.24,-10.96,;26.9,-11.73,;27.66,-13.05,;28.79,-11.93,;21.57,-13.26,;21.58,-11.72,;20.25,-10.95,;18.91,-11.72,;18.92,-13.27,;20.25,-14.03,)|
Show InChI InChI=1S/C26H35N2O2/c1-2-3-17-27(24-12-8-5-9-13-24)26(29)30-25-21-28(19-15-23(25)16-20-28)18-14-22-10-6-4-7-11-22/h4-13,23,25H,2-3,14-21H2,1H3/q+1/t23?,25-,28?/m0/s1
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n/an/a 121n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))		BDBM50344284
PNG
(CHEMBL1200803 | Solifenacin | Solifenacin succinat...)
Show SMILES O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2[C@@H]1c1ccccc1 |r,wD:3.2,20.24,THB:2:3:9.10:7.6,(12.11,-12.08,;13.44,-12.86,;14.78,-12.1,;14.78,-10.57,;14.5,-9.18,;13.16,-8.57,;13.23,-6.92,;13.67,-8.04,;13.42,-9.94,;11.89,-10.59,;11.69,-9.21,;13.43,-14.39,;14.77,-15.19,;14.73,-16.74,;13.38,-17.48,;13.37,-19.02,;12.02,-19.77,;10.7,-18.97,;10.72,-17.43,;12.06,-16.69,;12.08,-15.14,;10.76,-14.35,;9.42,-15.1,;8.1,-14.31,;8.13,-12.76,;9.47,-12.02,;10.79,-12.81,)|
Show InChI InChI=1S/C23H26N2O2/c26-23(27-21-16-24-13-10-18(21)11-14-24)25-15-12-17-6-4-5-9-20(17)22(25)19-7-2-1-3-8-19/h1-9,18,21-22H,10-16H2/t21-,22-/m0/s1
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n/an/a 131n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50344279
PNG
((R)-quinuclidin-3-yl benzyl(p-tolyl)carbamate | CH...)
Show SMILES Cc1ccc(cc1)N(Cc1ccccc1)C(=O)O[C@H]1CN2CCC1CC2 |r,wD:18.19,(-10.57,-40.15,;-9.24,-40.92,;-9.23,-42.47,;-7.9,-43.23,;-6.58,-42.46,;-6.57,-40.92,;-7.91,-40.15,;-5.25,-43.23,;-5.25,-44.77,;-3.92,-45.54,;-3.92,-47.08,;-2.59,-47.85,;-1.26,-47.08,;-1.26,-45.53,;-2.59,-44.77,;-3.92,-42.46,;-3.92,-40.92,;-2.58,-43.23,;-1.25,-42.46,;.08,-43.24,;1.41,-42.47,;1.42,-40.93,;.09,-40.16,;-1.25,-40.93,;-.5,-42.25,;.63,-41.13,)|
Show InChI InChI=1S/C22H26N2O2/c1-17-7-9-20(10-8-17)24(15-18-5-3-2-4-6-18)22(25)26-21-16-23-13-11-19(21)12-14-23/h2-10,19,21H,11-16H2,1H3/t21-/m0/s1
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n/an/a 196n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50344302
PNG
((R)-quinuclidin-3-yl diphenylcarbamate | CHEMBL177...)
Show SMILES O=C(O[C@H]1CN2CCC1CC2)N(c1ccccc1)c1ccccc1 |r,wD:3.2,(-4.13,3.23,;-4.13,1.69,;-2.8,.92,;-1.47,1.69,;-.13,.92,;1.19,1.68,;1.2,3.22,;-.13,3.99,;-1.47,3.23,;-.71,1.9,;.41,3.02,;-5.46,.92,;-5.46,-.61,;-6.8,-1.38,;-6.8,-2.92,;-5.47,-3.69,;-4.13,-2.91,;-4.14,-1.38,;-6.79,1.69,;-6.79,3.23,;-8.12,4,;-9.46,3.23,;-9.45,1.69,;-8.12,.93,)|
Show InChI InChI=1S/C20H22N2O2/c23-20(24-19-15-21-13-11-16(19)12-14-21)22(17-7-3-1-4-8-17)18-9-5-2-6-10-18/h1-10,16,19H,11-15H2/t19-/m0/s1
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n/an/a 319n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50344272
PNG
((R)-quinuclidin-3-yl phenyl(propyl)carbamate | CHE...)
Show SMILES CCCN(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1 |r,wD:7.6,(23.62,-14.44,;23.62,-12.9,;24.95,-12.13,;24.95,-10.59,;26.28,-9.82,;26.28,-8.28,;27.62,-10.59,;28.95,-9.82,;30.28,-10.59,;31.61,-9.83,;31.62,-8.29,;30.29,-7.51,;28.95,-8.28,;29.7,-9.61,;30.83,-8.49,;23.62,-9.82,;23.63,-8.27,;22.29,-7.5,;20.96,-8.27,;20.96,-9.82,;22.3,-10.58,)|
Show InChI InChI=1S/C17H24N2O2/c1-2-10-19(15-6-4-3-5-7-15)17(20)21-16-13-18-11-8-14(16)9-12-18/h3-7,14,16H,2,8-13H2,1H3/t16-/m0/s1
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n/an/a 349n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))		BDBM50344275
PNG
((R)-quinuclidin-3-yl isopropyl(phenyl)carbamate | ...)
Show SMILES CC(C)N(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1 |r,wD:7.6,(26.28,-23.64,;24.94,-22.87,;23.61,-23.64,;24.94,-21.33,;26.28,-20.56,;26.28,-19.02,;27.61,-21.33,;28.94,-20.56,;30.28,-21.34,;31.61,-20.58,;31.61,-19.04,;30.28,-18.26,;28.94,-19.03,;29.7,-20.35,;30.82,-19.23,;23.61,-20.56,;23.62,-19.02,;22.29,-18.25,;20.95,-19.02,;20.96,-20.57,;22.29,-21.33,)|
Show InChI InChI=1S/C17H24N2O2/c1-13(2)19(15-6-4-3-5-7-15)17(20)21-16-12-18-10-8-14(16)9-11-18/h3-7,13-14,16H,8-12H2,1-2H3/t16-/m0/s1
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n/an/a 428n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50344284
PNG
(CHEMBL1200803 | Solifenacin | Solifenacin succinat...)
Show SMILES O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2[C@@H]1c1ccccc1 |r,wD:3.2,20.24,THB:2:3:9.10:7.6,(12.11,-12.08,;13.44,-12.86,;14.78,-12.1,;14.78,-10.57,;14.5,-9.18,;13.16,-8.57,;13.23,-6.92,;13.67,-8.04,;13.42,-9.94,;11.89,-10.59,;11.69,-9.21,;13.43,-14.39,;14.77,-15.19,;14.73,-16.74,;13.38,-17.48,;13.37,-19.02,;12.02,-19.77,;10.7,-18.97,;10.72,-17.43,;12.06,-16.69,;12.08,-15.14,;10.76,-14.35,;9.42,-15.1,;8.1,-14.31,;8.13,-12.76,;9.47,-12.02,;10.79,-12.81,)|
Show InChI InChI=1S/C23H26N2O2/c26-23(27-21-16-24-13-10-18(21)11-14-24)25-15-12-17-6-4-5-9-20(17)22(25)19-7-2-1-3-8-19/h1-9,18,21-22H,10-16H2/t21-,22-/m0/s1
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n/an/a 574n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))		BDBM50344275
PNG
((R)-quinuclidin-3-yl isopropyl(phenyl)carbamate | ...)
Show SMILES CC(C)N(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1 |r,wD:7.6,(26.28,-23.64,;24.94,-22.87,;23.61,-23.64,;24.94,-21.33,;26.28,-20.56,;26.28,-19.02,;27.61,-21.33,;28.94,-20.56,;30.28,-21.34,;31.61,-20.58,;31.61,-19.04,;30.28,-18.26,;28.94,-19.03,;29.7,-20.35,;30.82,-19.23,;23.61,-20.56,;23.62,-19.02,;22.29,-18.25,;20.95,-19.02,;20.96,-20.57,;22.29,-21.33,)|
Show InChI InChI=1S/C17H24N2O2/c1-13(2)19(15-6-4-3-5-7-15)17(20)21-16-12-18-10-8-14(16)9-11-18/h3-7,13-14,16H,8-12H2,1-2H3/t16-/m0/s1
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n/an/a 659n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))		BDBM50344302
PNG
((R)-quinuclidin-3-yl diphenylcarbamate | CHEMBL177...)
Show SMILES O=C(O[C@H]1CN2CCC1CC2)N(c1ccccc1)c1ccccc1 |r,wD:3.2,(-4.13,3.23,;-4.13,1.69,;-2.8,.92,;-1.47,1.69,;-.13,.92,;1.19,1.68,;1.2,3.22,;-.13,3.99,;-1.47,3.23,;-.71,1.9,;.41,3.02,;-5.46,.92,;-5.46,-.61,;-6.8,-1.38,;-6.8,-2.92,;-5.47,-3.69,;-4.13,-2.91,;-4.14,-1.38,;-6.79,1.69,;-6.79,3.23,;-8.12,4,;-9.46,3.23,;-9.45,1.69,;-8.12,.93,)|
Show InChI InChI=1S/C20H22N2O2/c23-20(24-19-15-21-13-11-16(19)12-14-21)22(17-7-3-1-4-8-17)18-9-5-2-6-10-18/h1-10,16,19H,11-15H2/t19-/m0/s1
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n/an/a 797n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50344275
PNG
((R)-quinuclidin-3-yl isopropyl(phenyl)carbamate | ...)
Show SMILES CC(C)N(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1 |r,wD:7.6,(26.28,-23.64,;24.94,-22.87,;23.61,-23.64,;24.94,-21.33,;26.28,-20.56,;26.28,-19.02,;27.61,-21.33,;28.94,-20.56,;30.28,-21.34,;31.61,-20.58,;31.61,-19.04,;30.28,-18.26,;28.94,-19.03,;29.7,-20.35,;30.82,-19.23,;23.61,-20.56,;23.62,-19.02,;22.29,-18.25,;20.95,-19.02,;20.96,-20.57,;22.29,-21.33,)|
Show InChI InChI=1S/C17H24N2O2/c1-13(2)19(15-6-4-3-5-7-15)17(20)21-16-12-18-10-8-14(16)9-11-18/h3-7,13-14,16H,8-12H2,1-2H3/t16-/m0/s1
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n/an/a 1.36E+3n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))		BDBM50344302
PNG
((R)-quinuclidin-3-yl diphenylcarbamate | CHEMBL177...)
Show SMILES O=C(O[C@H]1CN2CCC1CC2)N(c1ccccc1)c1ccccc1 |r,wD:3.2,(-4.13,3.23,;-4.13,1.69,;-2.8,.92,;-1.47,1.69,;-.13,.92,;1.19,1.68,;1.2,3.22,;-.13,3.99,;-1.47,3.23,;-.71,1.9,;.41,3.02,;-5.46,.92,;-5.46,-.61,;-6.8,-1.38,;-6.8,-2.92,;-5.47,-3.69,;-4.13,-2.91,;-4.14,-1.38,;-6.79,1.69,;-6.79,3.23,;-8.12,4,;-9.46,3.23,;-9.45,1.69,;-8.12,.93,)|
Show InChI InChI=1S/C20H22N2O2/c23-20(24-19-15-21-13-11-16(19)12-14-21)22(17-7-3-1-4-8-17)18-9-5-2-6-10-18/h1-10,16,19H,11-15H2/t19-/m0/s1
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n/an/a 2.78E+3n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting

Bioorg Med Chem Lett 21: 3457-61 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.096
BindingDB Entry DOI: 10.7270/Q25H7GMV
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%