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PubMed code 2153820

Compile data set for download or QSAR
Found 86 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50228640
PNG
(CHEMBL1203556)
Show SMILES Cl.Cl.Fc1cccc2CN(CC3=NCCN3)CCc12 |t:9|
Show InChI InChI=1S/C13H16FN3/c14-12-3-1-2-10-8-17(7-4-11(10)12)9-13-15-5-6-16-13/h1-3H,4-9H2,(H,15,16)
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 4.10n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to the alpha-2 adrenergic receptor of rat cerebral cortex assayed using [3H]idazoxan as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50228625
PNG
(CHEMBL2448022)
Show SMILES Cl.Cl.Clc1cccc2CN(CC3=NCCN3)Cc12 |t:9|
Show InChI InChI=1S/C12H14ClN3/c13-11-3-1-2-9-6-16(7-10(9)11)8-12-14-4-5-15-12/h1-3H,4-8H2,(H,14,15)
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 4.20n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to the alpha-2 adrenergic receptor of rat cerebral cortex assayed using [3H]idazoxan as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50228639
PNG
(CHEMBL1203560)
Show SMILES Cl.Cl.Fc1cccc2CCN(CC3=NCCN3)Cc12 |t:10|
Show InChI InChI=1S/C13H16FN3/c14-12-3-1-2-10-4-7-17(8-11(10)12)9-13-15-5-6-16-13/h1-3H,4-9H2,(H,15,16)
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 5.40n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to the alpha-2 adrenergic receptor of rat cerebral cortex assayed using [3H]idazoxan as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50228635
PNG
(CHEMBL2448029)
Show SMILES Cl.Cl.Clc1cccc2CCN(CC3=NCCN3)Cc12 |t:10|
Show InChI InChI=1S/C13H16ClN3/c14-12-3-1-2-10-4-7-17(8-11(10)12)9-13-15-5-6-16-13/h1-3H,4-9H2,(H,15,16)
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 5.90n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity was determined against alpha-2 adrenergic receptor of rat cerebral cortex using [3H]idazoxan as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50026636
PNG
(17alpha-hydroxy-20alpha-yohimban-16beta-carboxylic...)
Show SMILES COC(=O)[C@@H]1[C@@H](O)CC[C@@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12 |r|
Show InChI InChI=1S/C21H26N2O3/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24/h2-5,12,15,17-19,22,24H,6-11H2,1H3/t12-,15+,17+,18+,19+/m1/s1
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 7.10n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor of rat cerebral cortex assayed using [3H]yohimbine as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50019848
PNG
(2-(2,3-dihydro-1,4-benzodioxin-2-yl)-4,5-dihydro-1...)
Show SMILES C1CN=C(N1)C1COc2ccccc2O1 |c:2|
Show InChI InChI=1S/C11H12N2O2/c1-2-4-9-8(3-1)14-7-10(15-9)11-12-5-6-13-11/h1-4,10H,5-7H2,(H,12,13)
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 7.60n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to the alpha-2 adrenergic receptor of rat cerebral cortex assayed using [3H]idazoxan as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50228638
PNG
(CHEMBL2448025)
Show SMILES Cl.Cl.Clc1ccc(Cl)c2CN(CC3=NCCN3)CCc12 |t:10|
Show InChI InChI=1S/C13H15Cl2N3/c14-11-1-2-12(15)10-7-18(6-3-9(10)11)8-13-16-4-5-17-13/h1-2H,3-8H2,(H,16,17)
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 7.60n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to the alpha-2 adrenergic receptor of rat cerebral cortex assayed using [3H]idazoxan as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50228629
PNG
(CHEMBL1203563)
Show SMILES Cl.Cl.C(N1Cc2ccccc2C1)C1=NCCN1 |t:12|
Show InChI InChI=1S/C12H15N3/c1-2-4-11-8-15(7-10(11)3-1)9-12-13-5-6-14-12/h1-4H,5-9H2,(H,13,14)
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 8.5n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity was determined against alpha-2 adrenergic receptor of rat cerebral cortex using [3H]idazoxan as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50228620
PNG
(CHEMBL1203559)
Show SMILES Cl.Cl.COc1cccc2CN(CC3=NCCN3)CCc12 |t:10|
Show InChI InChI=1S/C14H19N3O/c1-18-13-4-2-3-11-9-17(8-5-12(11)13)10-14-15-6-7-16-14/h2-4H,5-10H2,1H3,(H,15,16)
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 10n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to the alpha-2 adrenergic receptor of rat cerebral cortex assayed using [3H]idazoxan as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50019848
PNG
(2-(2,3-dihydro-1,4-benzodioxin-2-yl)-4,5-dihydro-1...)
Show SMILES C1CN=C(N1)C1COc2ccccc2O1 |c:2|
Show InChI InChI=1S/C11H12N2O2/c1-2-4-9-8(3-1)14-7-10(15-9)11-12-5-6-13-11/h1-4,10H,5-7H2,(H,12,13)
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 11n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor of rat cerebral cortex assayed using [3H]yohimbine as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50013515
PNG
((+)-yohimbine | (16alpha,17alpha)-17-hydroxyyohimb...)
Show SMILES COC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12 |r|
Show InChI InChI=1S/C21H26N2O3/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24/h2-5,12,15,17-19,22,24H,6-11H2,1H3/t12-,15-,17-,18-,19+/m0/s1
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 13n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor of rat cerebral cortex assayed using [3H]yohimbine as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50228636
PNG
(CHEMBL2448027)
Show SMILES Cl.Cl.Clc1cccc2CN(CC3=NCCN3)CCc12 |t:9|
Show InChI InChI=1S/C13H16ClN3/c14-12-3-1-2-10-8-17(7-4-11(10)12)9-13-15-5-6-16-13/h1-3H,4-9H2,(H,15,16)
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 16n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to the alpha-2 adrenergic receptor of rat cerebral cortex assayed using [3H]idazoxan as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50228630
PNG
(CHEMBL1203571)
Show SMILES Cl.Cl.COc1ccc(OC)c2CN(CC3=NCCN3)CCc12 |t:12|
Show InChI InChI=1S/C15H21N3O2/c1-19-13-3-4-14(20-2)12-9-18(8-5-11(12)13)10-15-16-6-7-17-15/h3-4H,5-10H2,1-2H3,(H,16,17)
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 16n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to the alpha-2 adrenergic receptor of rat cerebral cortex assayed using [3H]idazoxan as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50228631
PNG
(CHEMBL1203553)
Show SMILES Cl.Cl.C(N1CCc2ccccc2C1)C1=NCCN1 |t:13|
Show InChI InChI=1S/C13H17N3/c1-2-4-12-9-16(8-5-11(12)3-1)10-13-14-6-7-15-13/h1-4H,5-10H2,(H,14,15)
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 17n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to the alpha-2 adrenergic receptor of rat cerebral cortex assayed using [3H]idazoxan as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50228625
PNG
(CHEMBL2448022)
Show SMILES Cl.Cl.Clc1cccc2CN(CC3=NCCN3)Cc12 |t:9|
Show InChI InChI=1S/C12H14ClN3/c13-11-3-1-2-9-6-16(7-10(9)11)8-12-14-4-5-15-12/h1-3H,4-8H2,(H,14,15)
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 19n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor of rat cerebral cortex assayed using [3H]yohimbine as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50228627
PNG
(CHEMBL1203566)
Show SMILES Cl.Cl.COc1ccc(OC)c2C(C)N(CC3=NCCN3)CCc12 |t:13|
Show InChI InChI=1S/C16H23N3O2.2ClH/c1-11-16-12(13(20-2)4-5-14(16)21-3)6-9-19(11)10-15-17-7-8-18-15;;/h4-5,11H,6-10H2,1-3H3,(H,17,18);2*1H
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 19n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity was determined against alpha-2 adrenergic receptor of rat cerebral cortex using [3H]yohimbine as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50228621
PNG
(CHEMBL2448024)
Show SMILES Cl.Cl.Clc1ccc2CN(CC3=NCCN3)CCc2c1Cl |t:8|
Show InChI InChI=1S/C13H15Cl2N3/c14-11-2-1-9-7-18(6-3-10(9)13(11)15)8-12-16-4-5-17-12/h1-2H,3-8H2,(H,16,17)
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 21n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to the alpha-2 adrenergic receptor of rat cerebral cortex assayed using [3H]idazoxan as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50228618
PNG
(CHEMBL2448023)
Show SMILES Cl.Cl.Clc1ccc2CCN(CC3=NCCN3)Cc2c1Cl |t:9|
Show InChI InChI=1S/C13H15Cl2N3/c14-11-2-1-9-3-6-18(7-10(9)13(11)15)8-12-16-4-5-17-12/h1-2H,3-8H2,(H,16,17)
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 21n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to the alpha-2 adrenergic receptor of rat cerebral cortex assayed using [3H]idazoxan as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50228636
PNG
(CHEMBL2448027)
Show SMILES Cl.Cl.Clc1cccc2CN(CC3=NCCN3)CCc12 |t:9|
Show InChI InChI=1S/C13H16ClN3/c14-12-3-1-2-10-8-17(7-4-11(10)12)9-13-15-5-6-16-13/h1-3H,4-9H2,(H,15,16)
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 22n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor of rat cerebral cortex assayed using [3H]yohimbine as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50228634
PNG
(CHEMBL2448026)
Show SMILES Cl.Cl.CC1N(CC2=NCCN2)CCc2c(Cl)cccc12 |t:4|
Show InChI InChI=1S/C14H18ClN3.2ClH/c1-10-11-3-2-4-13(15)12(11)5-8-18(10)9-14-16-6-7-17-14;;/h2-4,10H,5-9H2,1H3,(H,16,17);2*1H
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 24n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to the alpha-2 adrenergic receptor of rat cerebral cortex assayed using [3H]idazoxan as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50228630
PNG
(CHEMBL1203571)
Show SMILES Cl.Cl.COc1ccc(OC)c2CN(CC3=NCCN3)CCc12 |t:12|
Show InChI InChI=1S/C15H21N3O2/c1-19-13-3-4-14(20-2)12-9-18(8-5-11(12)13)10-15-16-6-7-17-15/h3-4H,5-10H2,1-2H3,(H,16,17)
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 31n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor of rat cerebral cortex assayed using [3H]yohimbine as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50228640
PNG
(CHEMBL1203556)
Show SMILES Cl.Cl.Fc1cccc2CN(CC3=NCCN3)CCc12 |t:9|
Show InChI InChI=1S/C13H16FN3/c14-12-3-1-2-10-8-17(7-4-11(10)12)9-13-15-5-6-16-13/h1-3H,4-9H2,(H,15,16)
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 33n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor of rat cerebral cortex assayed using [3H]yohimbine as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50228623
PNG
(CHEMBL1203561)
Show SMILES Cl.Cl.Cc1cccc2CN(CC3=NCCN3)CCc12 |t:9|
Show InChI InChI=1S/C14H19N3/c1-11-3-2-4-12-9-17(8-5-13(11)12)10-14-15-6-7-16-14/h2-4H,5-10H2,1H3,(H,15,16)
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 42n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to the alpha-2 adrenergic receptor of rat cerebral cortex assayed using [3H]idazoxan as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50228637
PNG
(CHEMBL1203555)
Show SMILES Cl.Cl.CC1Cc2ccccc2CN1CC1=NCCN1 |t:14|
Show InChI InChI=1S/C14H19N3.2ClH/c1-11-8-12-4-2-3-5-13(12)9-17(11)10-14-15-6-7-16-14;;/h2-5,11H,6-10H2,1H3,(H,15,16);2*1H
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 42n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to the alpha-2 adrenergic receptor of rat cerebral cortex assayed using [3H]idazoxan as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50228624
PNG
(CHEMBL1203554)
Show SMILES Cl.Cl.CC1N(CC2=NCCN2)CCc2ccccc12 |t:4|
Show InChI InChI=1S/C14H19N3.2ClH/c1-11-13-5-3-2-4-12(13)6-9-17(11)10-14-15-7-8-16-14;;/h2-5,11H,6-10H2,1H3,(H,15,16);2*1H
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 48n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to the alpha-2 adrenergic receptor of rat cerebral cortex assayed using [3H]idazoxan as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50013515
PNG
((+)-yohimbine | (16alpha,17alpha)-17-hydroxyyohimb...)
Show SMILES COC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12 |r|
Show InChI InChI=1S/C21H26N2O3/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24/h2-5,12,15,17-19,22,24H,6-11H2,1H3/t12-,15-,17-,18-,19+/m0/s1
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 56n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to the alpha-2 adrenergic receptor of rat cerebral cortex assayed using [3H]idazoxan as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50228639
PNG
(CHEMBL1203560)
Show SMILES Cl.Cl.Fc1cccc2CCN(CC3=NCCN3)Cc12 |t:10|
Show InChI InChI=1S/C13H16FN3/c14-12-3-1-2-10-4-7-17(8-11(10)12)9-13-15-5-6-16-13/h1-3H,4-9H2,(H,15,16)
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 56n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor of rat cerebral cortex assayed using [3H]yohimbine as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50228632
PNG
(CHEMBL1203569)
Show SMILES Cl.Cl.COc1cc2CCN(CC3=NCCN3)Cc2c(OC)c1 |t:9|
Show InChI InChI=1S/C15H21N3O2/c1-19-12-7-11-3-6-18(10-15-16-4-5-17-15)9-13(11)14(8-12)20-2/h7-8H,3-6,9-10H2,1-2H3,(H,16,17)
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 63n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to the alpha-2 adrenergic receptor of rat cerebral cortex assayed using [3H]idazoxan as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50228624
PNG
(CHEMBL1203554)
Show SMILES Cl.Cl.CC1N(CC2=NCCN2)CCc2ccccc12 |t:4|
Show InChI InChI=1S/C14H19N3.2ClH/c1-11-13-5-3-2-4-12(13)6-9-17(11)10-14-15-7-8-16-14;;/h2-5,11H,6-10H2,1H3,(H,15,16);2*1H
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 65n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor of rat cerebral cortex assayed using [3H]yohimbine as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50228622
PNG
(CHEMBL1203558)
Show SMILES Cl.Cl.[O-][N+](=O)c1cccc2CN(CC3=NCCN3)CCc12 |t:11|
Show InChI InChI=1S/C13H16N4O2/c18-17(19)12-3-1-2-10-8-16(7-4-11(10)12)9-13-14-5-6-15-13/h1-3H,4-9H2,(H,14,15)
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 72n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to the alpha-2 adrenergic receptor of rat cerebral cortex assayed using [3H]idazoxan as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50228638
PNG
(CHEMBL2448025)
Show SMILES Cl.Cl.Clc1ccc(Cl)c2CN(CC3=NCCN3)CCc12 |t:10|
Show InChI InChI=1S/C13H15Cl2N3/c14-11-1-2-12(15)10-7-18(6-3-9(10)11)8-13-16-4-5-17-13/h1-2H,3-8H2,(H,16,17)
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 72n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor of rat cerebral cortex assayed using [3H]yohimbine as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50026636
PNG
(17alpha-hydroxy-20alpha-yohimban-16beta-carboxylic...)
Show SMILES COC(=O)[C@@H]1[C@@H](O)CC[C@@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12 |r|
Show InChI InChI=1S/C21H26N2O3/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24/h2-5,12,15,17-19,22,24H,6-11H2,1H3/t12-,15+,17+,18+,19+/m1/s1
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 81n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to the alpha-2 adrenergic receptor of rat cerebral cortex assayed using [3H]idazoxan as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50228620
PNG
(CHEMBL1203559)
Show SMILES Cl.Cl.COc1cccc2CN(CC3=NCCN3)CCc12 |t:10|
Show InChI InChI=1S/C14H19N3O/c1-18-13-4-2-3-11-9-17(8-5-12(11)13)10-14-15-6-7-16-14/h2-4H,5-10H2,1H3,(H,15,16)
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 85n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor of rat cerebral cortex assayed using [3H]yohimbine as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50228627
PNG
(CHEMBL1203566)
Show SMILES Cl.Cl.COc1ccc(OC)c2C(C)N(CC3=NCCN3)CCc12 |t:13|
Show InChI InChI=1S/C16H23N3O2.2ClH/c1-11-16-12(13(20-2)4-5-14(16)21-3)6-9-19(11)10-15-17-7-8-18-15;;/h4-5,11H,6-10H2,1-3H3,(H,17,18);2*1H
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 95n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity was determined against alpha-2 adrenergic receptor of rat cerebral cortex using [3H]idazoxan as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50228641
PNG
(CHEMBL1203557)
Show SMILES Cl.Nc1cccc2CN(CC3=NCCN3)CCc12 |t:9|
Show InChI InChI=1S/C13H18N4/c14-12-3-1-2-10-8-17(7-4-11(10)12)9-13-15-5-6-16-13/h1-3H,4-9,14H2,(H,15,16)
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 102n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to the alpha-2 adrenergic receptor of rat cerebral cortex assayed using [3H]idazoxan as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50228629
PNG
(CHEMBL1203563)
Show SMILES Cl.Cl.C(N1Cc2ccccc2C1)C1=NCCN1 |t:12|
Show InChI InChI=1S/C12H15N3/c1-2-4-11-8-15(7-10(11)3-1)9-12-13-5-6-14-12/h1-4H,5-9H2,(H,13,14)
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 123n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity was determined against alpha-2 adrenergic receptor of rat cerebral cortex using [3H]yohimbine as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50228637
PNG
(CHEMBL1203555)
Show SMILES Cl.Cl.CC1Cc2ccccc2CN1CC1=NCCN1 |t:14|
Show InChI InChI=1S/C14H19N3.2ClH/c1-11-8-12-4-2-3-5-13(12)9-17(11)10-14-15-6-7-16-14;;/h2-5,11H,6-10H2,1H3,(H,15,16);2*1H
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 126n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor of rat cerebral cortex assayed using [3H]yohimbine as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50228626
PNG
(CHEMBL2448028)
Show SMILES Cl.Cl.Clc1ccc2CN(CC3=NCCN3)CCc2c1 |t:8|
Show InChI InChI=1S/C13H16ClN3/c14-12-2-1-11-8-17(6-3-10(11)7-12)9-13-15-4-5-16-13/h1-2,7H,3-6,8-9H2,(H,15,16)
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 148n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity was determined against alpha-2 adrenergic receptor of rat cerebral cortex using [3H]idazoxan as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50228634
PNG
(CHEMBL2448026)
Show SMILES Cl.Cl.CC1N(CC2=NCCN2)CCc2c(Cl)cccc12 |t:4|
Show InChI InChI=1S/C14H18ClN3.2ClH/c1-10-11-3-2-4-13(15)12(11)5-8-18(10)9-14-16-6-7-17-14;;/h2-4,10H,5-9H2,1H3,(H,16,17);2*1H
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 182n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor of rat cerebral cortex assayed using [3H]yohimbine as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50228619
PNG
(CHEMBL1203562)
Show SMILES Cl.Cl.CC1(C)N(CC2=NCCN2)CCc2ccccc12 |t:5|
Show InChI InChI=1S/C15H21N3/c1-15(2)13-6-4-3-5-12(13)7-10-18(15)11-14-16-8-9-17-14/h3-6H,7-11H2,1-2H3,(H,16,17)
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 209n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to the alpha-2 adrenergic receptor of rat cerebral cortex assayed using [3H]idazoxan as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50228635
PNG
(CHEMBL2448029)
Show SMILES Cl.Cl.Clc1cccc2CCN(CC3=NCCN3)Cc12 |t:10|
Show InChI InChI=1S/C13H16ClN3/c14-12-3-1-2-10-4-7-17(8-11(10)12)9-13-15-5-6-16-13/h1-3H,4-9H2,(H,15,16)
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 214n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity was determined against alpha-2 adrenergic receptor of rat cerebral cortex using [3H]yohimbine as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50228623
PNG
(CHEMBL1203561)
Show SMILES Cl.Cl.Cc1cccc2CN(CC3=NCCN3)CCc12 |t:9|
Show InChI InChI=1S/C14H19N3/c1-11-3-2-4-12-9-17(8-5-13(11)12)10-14-15-6-7-16-14/h2-4H,5-10H2,1H3,(H,15,16)
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 269n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor of rat cerebral cortex assayed using [3H]yohimbine as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50228618
PNG
(CHEMBL2448023)
Show SMILES Cl.Cl.Clc1ccc2CCN(CC3=NCCN3)Cc2c1Cl |t:9|
Show InChI InChI=1S/C13H15Cl2N3/c14-11-2-1-9-3-6-18(7-10(9)13(11)15)8-12-16-4-5-17-12/h1-2H,3-8H2,(H,16,17)
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 302n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor of rat cerebral cortex assayed using [3H]yohimbine as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50228628
PNG
(CHEMBL1203565)
Show SMILES Cl.Cl.COc1ccc2CN(CC3=NCCN3)CCc2c1OC |t:9|
Show InChI InChI=1S/C15H21N3O2/c1-19-13-4-3-11-9-18(10-14-16-6-7-17-14)8-5-12(11)15(13)20-2/h3-4H,5-10H2,1-2H3,(H,16,17)
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 363n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity was determined against alpha-2 adrenergic receptor of rat cerebral cortex using [3H]yohimbine as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50228621
PNG
(CHEMBL2448024)
Show SMILES Cl.Cl.Clc1ccc2CN(CC3=NCCN3)CCc2c1Cl |t:8|
Show InChI InChI=1S/C13H15Cl2N3/c14-11-2-1-9-7-18(6-3-10(9)13(11)15)8-12-16-4-5-17-12/h1-2H,3-8H2,(H,16,17)
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 380n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor of rat cerebral cortex assayed using [3H]yohimbine as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50228617
PNG
(CHEMBL1203552)
Show SMILES Cl.Cl.C=CCC1N(CC2=NCCN2)CCc2ccccc12 |t:6|
Show InChI InChI=1S/C16H21N3.2ClH/c1-2-5-15-14-7-4-3-6-13(14)8-11-19(15)12-16-17-9-10-18-16;;/h2-4,6-7,15H,1,5,8-12H2,(H,17,18);2*1H
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 389n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to the alpha-2 adrenergic receptor of rat cerebral cortex assayed using [3H]idazoxan as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50013515
PNG
((+)-yohimbine | (16alpha,17alpha)-17-hydroxyyohimb...)
Show SMILES COC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12 |r|
Show InChI InChI=1S/C21H26N2O3/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24/h2-5,12,15,17-19,22,24H,6-11H2,1H3/t12-,15-,17-,18-,19+/m0/s1
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 398n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity determined to alpha-1 adrenergic receptor of rat cerebral cortex using [3H]prazosin as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50228631
PNG
(CHEMBL1203553)
Show SMILES Cl.Cl.C(N1CCc2ccccc2C1)C1=NCCN1 |t:13|
Show InChI InChI=1S/C13H17N3/c1-2-4-12-9-16(8-5-11(12)3-1)10-13-14-6-7-15-13/h1-4H,5-10H2,(H,14,15)
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 479n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor of rat cerebral cortex assayed using [3H]yohimbine as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50228616
PNG
(CHEMBL1203564)
Show SMILES Cl.Cl.CCC1N(CC2=NCCN2)CCc2ccccc12 |t:5|
Show InChI InChI=1S/C15H21N3.2ClH/c1-2-14-13-6-4-3-5-12(13)7-10-18(14)11-15-16-8-9-17-15;;/h3-6,14H,2,7-11H2,1H3,(H,16,17);2*1H
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 490n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to the alpha-2 adrenergic receptor of rat cerebral cortex assayed using [3H]idazoxan as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50228632
PNG
(CHEMBL1203569)
Show SMILES Cl.Cl.COc1cc2CCN(CC3=NCCN3)Cc2c(OC)c1 |t:9|
Show InChI InChI=1S/C15H21N3O2/c1-19-12-7-11-3-6-18(10-15-16-4-5-17-15)9-13(11)14(8-12)20-2/h7-8H,3-6,9-10H2,1-2H3,(H,16,17)
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 513n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor of rat cerebral cortex assayed using [3H]yohimbine as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50228628
PNG
(CHEMBL1203565)
Show SMILES Cl.Cl.COc1ccc2CN(CC3=NCCN3)CCc2c1OC |t:9|
Show InChI InChI=1S/C15H21N3O2/c1-19-13-4-3-11-9-18(10-14-16-6-7-17-14)8-5-12(11)15(13)20-2/h3-4H,5-10H2,1-2H3,(H,16,17)
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 575n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity was determined against alpha-2 adrenergic receptor of rat cerebral cortex using [3H]idazoxan as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50228626
PNG
(CHEMBL2448028)
Show SMILES Cl.Cl.Clc1ccc2CN(CC3=NCCN3)CCc2c1 |t:8|
Show InChI InChI=1S/C13H16ClN3/c14-12-2-1-11-8-17(6-3-10(11)7-12)9-13-15-4-5-16-13/h1-2,7H,3-6,8-9H2,(H,15,16)
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 661n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity was determined against alpha-2 adrenergic receptor of rat cerebral cortex using [3H]yohimbine as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50228641
PNG
(CHEMBL1203557)
Show SMILES Cl.Nc1cccc2CN(CC3=NCCN3)CCc12 |t:9|
Show InChI InChI=1S/C13H18N4/c14-12-3-1-2-10-8-17(7-4-11(10)12)9-13-15-5-6-16-13/h1-3H,4-9,14H2,(H,15,16)
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 676n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor of rat cerebral cortex assayed using [3H]yohimbine as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50228616
PNG
(CHEMBL1203564)
Show SMILES Cl.Cl.CCC1N(CC2=NCCN2)CCc2ccccc12 |t:5|
Show InChI InChI=1S/C15H21N3.2ClH/c1-2-14-13-6-4-3-5-12(13)7-10-18(14)11-15-16-8-9-17-15;;/h3-6,14H,2,7-11H2,1H3,(H,16,17);2*1H
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 692n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor of rat cerebral cortex assayed using [3H]yohimbine as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50228622
PNG
(CHEMBL1203558)
Show SMILES Cl.Cl.[O-][N+](=O)c1cccc2CN(CC3=NCCN3)CCc12 |t:11|
Show InChI InChI=1S/C13H16N4O2/c18-17(19)12-3-1-2-10-8-16(7-4-11(10)12)9-13-14-5-6-15-13/h1-3H,4-9H2,(H,14,15)
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 741n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor of rat cerebral cortex assayed using [3H]yohimbine as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50228633
PNG
(CHEMBL1203570)
Show SMILES Cl.Cl.COc1cc2CCN(CC3=NCCN3)Cc2cc1OC |t:9|
Show InChI InChI=1S/C15H21N3O2/c1-19-13-7-11-3-6-18(10-15-16-4-5-17-15)9-12(11)8-14(13)20-2/h7-8H,3-6,9-10H2,1-2H3,(H,16,17)
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 741n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to the alpha-2 adrenergic receptor of rat cerebral cortex assayed using [3H]idazoxan as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50019848
PNG
(2-(2,3-dihydro-1,4-benzodioxin-2-yl)-4,5-dihydro-1...)
Show SMILES C1CN=C(N1)C1COc2ccccc2O1 |c:2|
Show InChI InChI=1S/C11H12N2O2/c1-2-4-9-8(3-1)14-7-10(15-9)11-12-5-6-13-11/h1-4,10H,5-7H2,(H,12,13)
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 794n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity determined to alpha-1 adrenergic receptor of rat cerebral cortex using [3H]prazosin as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50228625
PNG
(CHEMBL2448022)
Show SMILES Cl.Cl.Clc1cccc2CN(CC3=NCCN3)Cc12 |t:9|
Show InChI InChI=1S/C12H14ClN3/c13-11-3-1-2-9-6-16(7-10(9)11)8-12-14-4-5-15-12/h1-3H,4-8H2,(H,14,15)
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 891n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity determined to alpha-1 adrenergic receptor of rat cerebral cortex using [3H]prazosin as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50228619
PNG
(CHEMBL1203562)
Show SMILES Cl.Cl.CC1(C)N(CC2=NCCN2)CCc2ccccc12 |t:5|
Show InChI InChI=1S/C15H21N3/c1-15(2)13-6-4-3-5-12(13)7-10-18(15)11-14-16-8-9-17-14/h3-6H,7-11H2,1-2H3,(H,16,17)
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 1.00E+3n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor of rat cerebral cortex assayed using [3H]yohimbine as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50228617
PNG
(CHEMBL1203552)
Show SMILES Cl.Cl.C=CCC1N(CC2=NCCN2)CCc2ccccc12 |t:6|
Show InChI InChI=1S/C16H21N3.2ClH/c1-2-5-15-14-7-4-3-6-13(14)8-11-19(15)12-16-17-9-10-18-16;;/h2-4,6-7,15H,1,5,8-12H2,(H,17,18);2*1H
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 1.07E+3n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor of rat cerebral cortex assayed using [3H]yohimbine as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50228633
PNG
(CHEMBL1203570)
Show SMILES Cl.Cl.COc1cc2CCN(CC3=NCCN3)Cc2cc1OC |t:9|
Show InChI InChI=1S/C15H21N3O2/c1-19-13-7-11-3-6-18(10-15-16-4-5-17-15)9-12(11)8-14(13)20-2/h7-8H,3-6,9-10H2,1-2H3,(H,16,17)
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 1.35E+3n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2 adrenergic receptor of rat cerebral cortex assayed using [3H]yohimbine as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50228635
PNG
(CHEMBL2448029)
Show SMILES Cl.Cl.Clc1cccc2CCN(CC3=NCCN3)Cc12 |t:10|
Show InChI InChI=1S/C13H16ClN3/c14-12-3-1-2-10-4-7-17(8-11(10)12)9-13-15-5-6-16-13/h1-3H,4-9H2,(H,15,16)
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 1.59E+3n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity determined to alpha-1 adrenergic receptor of rat cerebral cortex using [3H]prazosin as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50228636
PNG
(CHEMBL2448027)
Show SMILES Cl.Cl.Clc1cccc2CN(CC3=NCCN3)CCc12 |t:9|
Show InChI InChI=1S/C13H16ClN3/c14-12-3-1-2-10-8-17(7-4-11(10)12)9-13-15-5-6-16-13/h1-3H,4-9H2,(H,15,16)
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 2.09E+3n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity determined to alpha-1 adrenergic receptor of rat cerebral cortex using [3H]prazosin as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50228631
PNG
(CHEMBL1203553)
Show SMILES Cl.Cl.C(N1CCc2ccccc2C1)C1=NCCN1 |t:13|
Show InChI InChI=1S/C13H17N3/c1-2-4-12-9-16(8-5-11(12)3-1)10-13-14-6-7-15-13/h1-4H,5-10H2,(H,14,15)
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 2.14E+3n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity determined to alpha-1 adrenergic receptor of rat cerebral cortex using [3H]prazosin as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50228640
PNG
(CHEMBL1203556)
Show SMILES Cl.Cl.Fc1cccc2CN(CC3=NCCN3)CCc12 |t:9|
Show InChI InChI=1S/C13H16FN3/c14-12-3-1-2-10-8-17(7-4-11(10)12)9-13-15-5-6-16-13/h1-3H,4-9H2,(H,15,16)
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 2.82E+3n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity determined to alpha-1 adrenergic receptor of rat cerebral cortex using [3H]prazosin as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50228638
PNG
(CHEMBL2448025)
Show SMILES Cl.Cl.Clc1ccc(Cl)c2CN(CC3=NCCN3)CCc12 |t:10|
Show InChI InChI=1S/C13H15Cl2N3/c14-11-1-2-12(15)10-7-18(6-3-9(10)11)8-13-16-4-5-17-13/h1-2H,3-8H2,(H,16,17)
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 3.16E+3n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity determined to alpha-1 adrenergic receptor of rat cerebral cortex using [3H]prazosin as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50228639
PNG
(CHEMBL1203560)
Show SMILES Cl.Cl.Fc1cccc2CCN(CC3=NCCN3)Cc12 |t:10|
Show InChI InChI=1S/C13H16FN3/c14-12-3-1-2-10-4-7-17(8-11(10)12)9-13-15-5-6-16-13/h1-3H,4-9H2,(H,15,16)
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 3.16E+3n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity determined to alpha-1 adrenergic receptor of rat cerebral cortex using [3H]prazosin as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50228629
PNG
(CHEMBL1203563)
Show SMILES Cl.Cl.C(N1Cc2ccccc2C1)C1=NCCN1 |t:12|
Show InChI InChI=1S/C12H15N3/c1-2-4-11-8-15(7-10(11)3-1)9-12-13-5-6-14-12/h1-4H,5-9H2,(H,13,14)
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 3.72E+3n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity determined to alpha-1 adrenergic receptor of rat cerebral cortex using [3H]prazosin as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50228623
PNG
(CHEMBL1203561)
Show SMILES Cl.Cl.Cc1cccc2CN(CC3=NCCN3)CCc12 |t:9|
Show InChI InChI=1S/C14H19N3/c1-11-3-2-4-12-9-17(8-5-13(11)12)10-14-15-6-7-16-14/h2-4H,5-10H2,1H3,(H,15,16)
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 5.50E+3n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity determined to alpha-1 adrenergic receptor of rat cerebral cortex using [3H]prazosin as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50228634
PNG
(CHEMBL2448026)
Show SMILES Cl.Cl.CC1N(CC2=NCCN2)CCc2c(Cl)cccc12 |t:4|
Show InChI InChI=1S/C14H18ClN3.2ClH/c1-10-11-3-2-4-13(15)12(11)5-8-18(10)9-14-16-6-7-17-14;;/h2-4,10H,5-9H2,1H3,(H,16,17);2*1H
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 6.31E+3n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity determined to alpha-1 adrenergic receptor of rat cerebral cortex using [3H]prazosin as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50228627
PNG
(CHEMBL1203566)
Show SMILES Cl.Cl.COc1ccc(OC)c2C(C)N(CC3=NCCN3)CCc12 |t:13|
Show InChI InChI=1S/C16H23N3O2.2ClH/c1-11-16-12(13(20-2)4-5-14(16)21-3)6-9-19(11)10-15-17-7-8-18-15;;/h4-5,11H,6-10H2,1-3H3,(H,17,18);2*1H
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 6.46E+3n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity determined to alpha-1 adrenergic receptor of rat cerebral cortex using [3H]prazosin as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50228624
PNG
(CHEMBL1203554)
Show SMILES Cl.Cl.CC1N(CC2=NCCN2)CCc2ccccc12 |t:4|
Show InChI InChI=1S/C14H19N3.2ClH/c1-11-13-5-3-2-4-12(13)6-9-17(11)10-14-15-7-8-16-14;;/h2-5,11H,6-10H2,1H3,(H,15,16);2*1H
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 7.24E+3n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity determined to alpha-1 adrenergic receptor of rat cerebral cortex using [3H]prazosin as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50228633
PNG
(CHEMBL1203570)
Show SMILES Cl.Cl.COc1cc2CCN(CC3=NCCN3)Cc2cc1OC |t:9|
Show InChI InChI=1S/C15H21N3O2/c1-19-13-7-11-3-6-18(10-15-16-4-5-17-15)9-12(11)8-14(13)20-2/h7-8H,3-6,9-10H2,1-2H3,(H,16,17)
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<1.00E+4n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity determined to alpha-1 adrenergic receptor of rat cerebral cortex using [3H]prazosin as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50228641
PNG
(CHEMBL1203557)
Show SMILES Cl.Nc1cccc2CN(CC3=NCCN3)CCc12 |t:9|
Show InChI InChI=1S/C13H18N4/c14-12-3-1-2-10-8-17(7-4-11(10)12)9-13-15-5-6-16-13/h1-3H,4-9,14H2,(H,15,16)
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<1.00E+4n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity determined to alpha-1 adrenergic receptor of rat cerebral cortex using [3H]prazosin as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50228632
PNG
(CHEMBL1203569)
Show SMILES Cl.Cl.COc1cc2CCN(CC3=NCCN3)Cc2c(OC)c1 |t:9|
Show InChI InChI=1S/C15H21N3O2/c1-19-12-7-11-3-6-18(10-15-16-4-5-17-15)9-13(11)14(8-12)20-2/h7-8H,3-6,9-10H2,1-2H3,(H,16,17)
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<1.00E+4n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity determined to alpha-1 adrenergic receptor of rat cerebral cortex using [3H]prazosin as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50228622
PNG
(CHEMBL1203558)
Show SMILES Cl.Cl.[O-][N+](=O)c1cccc2CN(CC3=NCCN3)CCc12 |t:11|
Show InChI InChI=1S/C13H16N4O2/c18-17(19)12-3-1-2-10-8-16(7-4-11(10)12)9-13-14-5-6-15-13/h1-3H,4-9H2,(H,14,15)
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<1.00E+4n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity determined to alpha-1 adrenergic receptor of rat cerebral cortex using [3H]prazosin as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50228628
PNG
(CHEMBL1203565)
Show SMILES Cl.Cl.COc1ccc2CN(CC3=NCCN3)CCc2c1OC |t:9|
Show InChI InChI=1S/C15H21N3O2/c1-19-13-4-3-11-9-18(10-14-16-6-7-17-14)8-5-12(11)15(13)20-2/h3-4H,5-10H2,1-2H3,(H,16,17)
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<1.00E+4n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity determined to alpha-1 adrenergic receptor of rat cerebral cortex using [3H]prazosin as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50228621
PNG
(CHEMBL2448024)
Show SMILES Cl.Cl.Clc1ccc2CN(CC3=NCCN3)CCc2c1Cl |t:8|
Show InChI InChI=1S/C13H15Cl2N3/c14-11-2-1-9-7-18(6-3-10(9)13(11)15)8-12-16-4-5-17-12/h1-2H,3-8H2,(H,16,17)
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<1.00E+4n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity determined to alpha-1 adrenergic receptor of rat cerebral cortex using [3H]prazosin as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50228617
PNG
(CHEMBL1203552)
Show SMILES Cl.Cl.C=CCC1N(CC2=NCCN2)CCc2ccccc12 |t:6|
Show InChI InChI=1S/C16H21N3.2ClH/c1-2-5-15-14-7-4-3-6-13(14)8-11-19(15)12-16-17-9-10-18-16;;/h2-4,6-7,15H,1,5,8-12H2,(H,17,18);2*1H
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<1.00E+4n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity determined to alpha-1 adrenergic receptor of rat cerebral cortex using [3H]prazosin as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50228618
PNG
(CHEMBL2448023)
Show SMILES Cl.Cl.Clc1ccc2CCN(CC3=NCCN3)Cc2c1Cl |t:9|
Show InChI InChI=1S/C13H15Cl2N3/c14-11-2-1-9-3-6-18(7-10(9)13(11)15)8-12-16-4-5-17-12/h1-2H,3-8H2,(H,16,17)
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<1.00E+4n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity determined to alpha-1 adrenergic receptor of rat cerebral cortex using [3H]prazosin as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50228616
PNG
(CHEMBL1203564)
Show SMILES Cl.Cl.CCC1N(CC2=NCCN2)CCc2ccccc12 |t:5|
Show InChI InChI=1S/C15H21N3.2ClH/c1-2-14-13-6-4-3-5-12(13)7-10-18(14)11-15-16-8-9-17-15;;/h3-6,14H,2,7-11H2,1H3,(H,16,17);2*1H
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<1.00E+4n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity determined to alpha-1 adrenergic receptor of rat cerebral cortex using [3H]prazosin as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50228619
PNG
(CHEMBL1203562)
Show SMILES Cl.Cl.CC1(C)N(CC2=NCCN2)CCc2ccccc12 |t:5|
Show InChI InChI=1S/C15H21N3/c1-15(2)13-6-4-3-5-12(13)7-10-18(15)11-14-16-8-9-17-14/h3-6H,7-11H2,1-2H3,(H,16,17)
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<1.00E+4n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity determined to alpha-1 adrenergic receptor of rat cerebral cortex using [3H]prazosin as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50228626
PNG
(CHEMBL2448028)
Show SMILES Cl.Cl.Clc1ccc2CN(CC3=NCCN3)CCc2c1 |t:8|
Show InChI InChI=1S/C13H16ClN3/c14-12-2-1-11-8-17(6-3-10(11)7-12)9-13-15-4-5-16-13/h1-2,7H,3-6,8-9H2,(H,15,16)
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<1.00E+4n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity determined to alpha-1 adrenergic receptor of rat cerebral cortex using [3H]prazosin as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50228637
PNG
(CHEMBL1203555)
Show SMILES Cl.Cl.CC1Cc2ccccc2CN1CC1=NCCN1 |t:14|
Show InChI InChI=1S/C14H19N3.2ClH/c1-11-8-12-4-2-3-5-13(12)9-17(11)10-14-15-6-7-16-14;;/h2-5,11H,6-10H2,1H3,(H,15,16);2*1H
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<1.00E+4n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity determined to alpha-1 adrenergic receptor of rat cerebral cortex using [3H]prazosin as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50228630
PNG
(CHEMBL1203571)
Show SMILES Cl.Cl.COc1ccc(OC)c2CN(CC3=NCCN3)CCc12 |t:12|
Show InChI InChI=1S/C15H21N3O2/c1-19-13-3-4-14(20-2)12-9-18(8-5-11(12)13)10-15-16-6-7-17-15/h3-4H,5-10H2,1-2H3,(H,16,17)
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 1.58E+4n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity determined to alpha-1 adrenergic receptor of rat cerebral cortex using [3H]prazosin as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50228620
PNG
(CHEMBL1203559)
Show SMILES Cl.Cl.COc1cccc2CN(CC3=NCCN3)CCc12 |t:10|
Show InChI InChI=1S/C14H19N3O/c1-18-13-4-2-3-11-9-17(8-5-12(11)13)10-14-15-6-7-16-14/h2-4H,5-10H2,1H3,(H,15,16)
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 1.91E+4n/an/an/an/an/an/an/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Binding affinity determined to alpha-1 adrenergic receptor of rat cerebral cortex using [3H]prazosin as radioligand

J Med Chem 33: 596-600 (1990)


BindingDB Entry DOI: 10.7270/Q2BK1FKZ
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%