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PubMed code 21561768

Compile data set for download or QSAR
Found 12 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50344636
PNG
(CHEMBL1779065 | N'1,N'7-bis((6-nitrobenzo[d][1,3]d...)
Show SMILES [O-][N+](=O)c1cc2OCOc2cc1[CH+][N-]NC(=O)CCCCCC(=O)NN=Cc1cc2OCOc2cc1[N+]([O-])=O |w:25.26|
Show InChI InChI=1S/C23H22N6O10/c30-22(26-24-10-14-6-18-20(38-12-36-18)8-16(14)28(32)33)4-2-1-3-5-23(31)27-25-11-15-7-19-21(39-13-37-19)9-17(15)29(34)35/h6-11H,1-5,12-13H2,(H,26,30)(H,27,31)
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n/an/a 780n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of purified c-Met using poly(glu,tyr) as substrate after 60 mins by ELISA

Bioorg Med Chem Lett 21: 3749-54 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.064
BindingDB Entry DOI: 10.7270/Q2V1254B
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50344633
PNG
(3-methyl-N-(4-(2-(2-oxoindolin-3-ylidene)hydrazine...)
Show SMILES Cc1cccc(c1)C(=O)Nc1ccc(cc1)C(=O)N\N=C1/C(=O)Nc2ccccc12
Show InChI InChI=1S/C23H18N4O3/c1-14-5-4-6-16(13-14)21(28)24-17-11-9-15(10-12-17)22(29)27-26-20-18-7-2-3-8-19(18)25-23(20)30/h2-13H,1H3,(H,24,28)(H,27,29)(H,25,26,30)
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n/an/a 1.30E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of purified c-Met using poly(glu,tyr) as substrate after 60 mins by ELISA

Bioorg Med Chem Lett 21: 3749-54 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.064
BindingDB Entry DOI: 10.7270/Q2V1254B
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50344641
PNG
(CHEMBL1779090 | N'-(5-bromo-1-(morpholinomethyl)-2...)
Show SMILES COc1ccc(cc1)C(=O)NN=C1C(=O)N(CN2CCOCC2)c2ccc(Br)cc12 |w:11.11|
Show InChI InChI=1S/C21H21BrN4O4/c1-29-16-5-2-14(3-6-16)20(27)24-23-19-17-12-15(22)4-7-18(17)26(21(19)28)13-25-8-10-30-11-9-25/h2-7,12H,8-11,13H2,1H3,(H,24,27)
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n/an/a 2.20E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of purified c-Met using poly(glu,tyr) as substrate after 60 mins by ELISA

Bioorg Med Chem Lett 21: 3749-54 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.064
BindingDB Entry DOI: 10.7270/Q2V1254B
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50344635
PNG
(CHEMBL1779064 | N-((5-(4-chloro-3-nitrophenyl)fura...)
Show SMILES [O-][N+](=O)c1cc(ccc1Cl)-c1ccc([CH-]\N=[NH+]\c2nncn2\N=C/c2ccc(o2)-c2ccc(Cl)c(c2)[N+]([O-])=O)o1
Show InChI InChI=1S/C24H13Cl2N8O6/c25-18-5-1-14(9-20(18)33(35)36)22-7-3-16(39-22)11-27-30-24-31-28-13-32(24)29-12-17-4-8-23(40-17)15-2-6-19(26)21(10-15)34(37)38/h1-13H/q-1/p+1/b29-12-,30-27+
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n/an/a 3.30E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of purified c-Met using poly(glu,tyr) as substrate after 60 mins by ELISA

Bioorg Med Chem Lett 21: 3749-54 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.064
BindingDB Entry DOI: 10.7270/Q2V1254B
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50344640
PNG
(CHEMBL1779089 | N'-(5-bromo-1-(morpholinomethyl)-2...)
Show SMILES Brc1ccc2N(CN3CCOCC3)C(=O)C(=NNC(=O)c3ccccc3)c2c1 |w:16.17|
Show InChI InChI=1S/C20H19BrN4O3/c21-15-6-7-17-16(12-15)18(22-23-19(26)14-4-2-1-3-5-14)20(27)25(17)13-24-8-10-28-11-9-24/h1-7,12H,8-11,13H2,(H,23,26)
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n/an/a 3.50E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of purified c-Met using poly(glu,tyr) as substrate after 60 mins by ELISA

Bioorg Med Chem Lett 21: 3749-54 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.064
BindingDB Entry DOI: 10.7270/Q2V1254B
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50344634
PNG
(2-(4-methoxyphenyl)-2-oxoethyl 2-(4-acetylphenyl)-...)
Show SMILES COc1ccc(cc1)C(=O)COC(=O)c1ccc2C(=O)N(C(=O)c2c1)c1ccc(cc1)C(C)=O
Show InChI InChI=1S/C26H19NO7/c1-15(28)16-3-8-19(9-4-16)27-24(30)21-12-7-18(13-22(21)25(27)31)26(32)34-14-23(29)17-5-10-20(33-2)11-6-17/h3-13H,14H2,1-2H3
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n/an/a 3.70E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of purified c-Met using poly(glu,tyr) as substrate after 60 mins by ELISA

Bioorg Med Chem Lett 21: 3749-54 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.064
BindingDB Entry DOI: 10.7270/Q2V1254B
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50344643
PNG
(3-hydroxy-N'-(2-oxoindolin-3-ylidene)-2-naphthohyd...)
Show SMILES Oc1cc2ccccc2cc1C(=O)NN=C1C(=O)Nc2ccccc12 |w:14.15|
Show InChI InChI=1S/C19H13N3O3/c23-16-10-12-6-2-1-5-11(12)9-14(16)18(24)22-21-17-13-7-3-4-8-15(13)20-19(17)25/h1-10,23H,(H,22,24)(H,20,21,25)
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n/an/a 4.30E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of purified c-Met using poly(glu,tyr) as substrate after 60 mins by ELISA

Bioorg Med Chem Lett 21: 3749-54 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.064
BindingDB Entry DOI: 10.7270/Q2V1254B
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50344638
PNG
(2-(3-(2-(5-bromo-2-hydroxybenzoyl)hydrazono)-2-oxo...)
Show SMILES Cc1ccc(NC(=O)CN2C(=O)C(=NNC(=O)c3cc(Br)ccc3O)c3ccccc23)cc1 |w:13.13|
Show InChI InChI=1S/C24H19BrN4O4/c1-14-6-9-16(10-7-14)26-21(31)13-29-19-5-3-2-4-17(19)22(24(29)33)27-28-23(32)18-12-15(25)8-11-20(18)30/h2-12,30H,13H2,1H3,(H,26,31)(H,28,32)
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n/an/a 8.10E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of purified c-Met using poly(glu,tyr) as substrate after 60 mins by ELISA

Bioorg Med Chem Lett 21: 3749-54 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.064
BindingDB Entry DOI: 10.7270/Q2V1254B
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50344632
PNG
(CHEMBL1779061 | N'1,N'3-bis(1-methyl-2-oxoindolin-...)
Show SMILES CN1C(=O)C(=NNC(=O)c2cccc(c2)C(=O)NN=C2C(=O)N(C)c3ccccc23)c2ccccc12 |w:18.18,5.5|
Show InChI InChI=1S/C26H20N6O4/c1-31-19-12-5-3-10-17(19)21(25(31)35)27-29-23(33)15-8-7-9-16(14-15)24(34)30-28-22-18-11-4-6-13-20(18)32(2)26(22)36/h3-14H,1-2H3,(H,29,33)(H,30,34)
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n/an/a 1.03E+4n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of purified c-Met using poly(glu,tyr) as substrate after 60 mins by ELISA

Bioorg Med Chem Lett 21: 3749-54 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.064
BindingDB Entry DOI: 10.7270/Q2V1254B
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50344637
PNG
(CHEMBL1779078 | N'-(1-methyl-2-oxoindolin-3-yliden...)
Show SMILES CN1C(=O)C(=NNC(=O)c2ccc(cc2)[N+]([O-])=O)c2ccccc12 |w:5.5|
Show InChI InChI=1S/C16H12N4O4/c1-19-13-5-3-2-4-12(13)14(16(19)22)17-18-15(21)10-6-8-11(9-7-10)20(23)24/h2-9H,1H3,(H,18,21)
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n/an/a 1.23E+4n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of purified c-Met using poly(glu,tyr) as substrate after 60 mins by ELISA

Bioorg Med Chem Lett 21: 3749-54 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.064
BindingDB Entry DOI: 10.7270/Q2V1254B
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50344639
PNG
(2-(3-(2-(4-aminobenzoyl)hydrazono)-2-oxoindolin-1-...)
Show SMILES Cc1ccc(NC(=O)CN2C(=O)C(=NNC(=O)c3ccc(N)cc3)c3ccccc23)cc1 |w:13.13|
Show InChI InChI=1S/C24H21N5O3/c1-15-6-12-18(13-7-15)26-21(30)14-29-20-5-3-2-4-19(20)22(24(29)32)27-28-23(31)16-8-10-17(25)11-9-16/h2-13H,14,25H2,1H3,(H,26,30)(H,28,31)
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n/an/a 1.58E+4n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of purified c-Met using poly(glu,tyr) as substrate after 60 mins by ELISA

Bioorg Med Chem Lett 21: 3749-54 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.064
BindingDB Entry DOI: 10.7270/Q2V1254B
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50344642
PNG
(4-nitro-N'-(2-oxoindolin-3-ylidene)benzohydrazide ...)
Show SMILES [O-][N+](=O)c1ccc(cc1)C(=O)NN=C1C(=O)Nc2ccccc12 |w:12.12|
Show InChI InChI=1S/C15H10N4O4/c20-14(9-5-7-10(8-6-9)19(22)23)18-17-13-11-3-1-2-4-12(11)16-15(13)21/h1-8H,(H,18,20)(H,16,17,21)
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n/an/a 2.83E+4n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of purified c-Met using poly(glu,tyr) as substrate after 60 mins by ELISA

Bioorg Med Chem Lett 21: 3749-54 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.064
BindingDB Entry DOI: 10.7270/Q2V1254B
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%