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PubMed code 21608528

Compile data set for download or QSAR
Found 166 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347672
PNG
(CHEMBL1802904)
Show SMILES CCN1CCC(CC1)n1cc(cn1)-c1cnc2ccc3ccc(NS(=O)(=O)N(C)C)cc3c(=O)c2c1
Show InChI InChI=1S/C26H30N6O3S/c1-4-31-11-9-22(10-12-31)32-17-20(16-28-32)19-13-24-25(27-15-19)8-6-18-5-7-21(14-23(18)26(24)33)29-36(34,35)30(2)3/h5-8,13-17,22,29H,4,9-12H2,1-3H3
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n/an/a 0.200n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluorescence reson...


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347697
PNG
(CHEMBL1802603)
Show SMILES Cn1cc(cn1)-c1cnc2ccc3ccc(N)cc3c(=O)c2c1
Show InChI InChI=1S/C18H14N4O/c1-22-10-13(9-21-22)12-6-16-17(20-8-12)5-3-11-2-4-14(19)7-15(11)18(16)23/h2-10H,19H2,1H3
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n/an/a 0.700n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluorescence reson...


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347675
PNG
(CHEMBL1802835)
Show SMILES CN(C)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(CC(F)CO)c1
Show InChI InChI=1S/C22H22FN5O4S/c1-27(2)33(31,32)26-18-5-3-14-4-6-21-20(22(30)19(14)8-18)7-15(9-24-21)16-10-25-28(11-16)12-17(23)13-29/h3-11,17,26,29H,12-13H2,1-2H3
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n/an/a 1n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluorescence reson...


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347667
PNG
(CHEMBL1802909)
Show SMILES CN(Cc1cnccn1)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1
Show InChI InChI=1S/C24H21N7O3S/c1-30-14-18(12-28-30)17-9-22-23(27-11-17)6-4-16-3-5-19(10-21(16)24(22)32)29-35(33,34)31(2)15-20-13-25-7-8-26-20/h3-14,29H,15H2,1-2H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluorescence reson...


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347669
PNG
(CHEMBL1802907)
Show SMILES CNS(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1
Show InChI InChI=1S/C19H17N5O3S/c1-20-28(26,27)23-15-5-3-12-4-6-18-17(19(25)16(12)8-15)7-13(9-21-18)14-10-22-24(2)11-14/h3-11,20,23H,1-2H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluorescence reson...


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347659
PNG
(CHEMBL1802916 | MK-2461)
Show SMILES CN(C[C@@H]1COCCO1)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1 |r|
Show InChI InChI=1S/C24H25N5O5S/c1-28-13-18(12-26-28)17-9-22-23(25-11-17)6-4-16-3-5-19(10-21(16)24(22)30)27-35(31,32)29(2)14-20-15-33-7-8-34-20/h3-6,9-13,20,27H,7-8,14-15H2,1-2H3/t20-/m1/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluorescence reson...


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347680
PNG
(CHEMBL1802830)
Show SMILES CCCn1cc(cn1)-c1cnc2ccc3ccc(NS(=O)(=O)N(C)C)cc3c(=O)c2c1
Show InChI InChI=1S/C22H23N5O3S/c1-4-9-27-14-17(13-24-27)16-10-20-21(23-12-16)8-6-15-5-7-18(11-19(15)22(20)28)25-31(29,30)26(2)3/h5-8,10-14,25H,4,9H2,1-3H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluorescence reson...


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347661
PNG
(CHEMBL1802914)
Show SMILES CN([C@H]1CCOC1)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1 |r|
Show InChI InChI=1S/C23H23N5O4S/c1-27-13-17(12-25-27)16-9-21-22(24-11-16)6-4-15-3-5-18(10-20(15)23(21)29)26-33(30,31)28(2)19-7-8-32-14-19/h3-6,9-13,19,26H,7-8,14H2,1-2H3/t19-/m0/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluorescence reson...


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347673
PNG
(CHEMBL1802903)
Show SMILES CN(C)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(CC(F)CN2CCCC2)c1
Show InChI InChI=1S/C26H29FN6O3S/c1-31(2)37(35,36)30-22-7-5-18-6-8-25-24(26(34)23(18)12-22)11-19(13-28-25)20-14-29-33(15-20)17-21(27)16-32-9-3-4-10-32/h5-8,11-15,21,30H,3-4,9-10,16-17H2,1-2H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluorescence reson...


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347679
PNG
(CHEMBL1802831)
Show SMILES CN(C)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(CC(=O)N2CCOCC2)c1
Show InChI InChI=1S/C25H26N6O5S/c1-29(2)37(34,35)28-20-5-3-17-4-6-23-22(25(33)21(17)12-20)11-18(13-26-23)19-14-27-31(15-19)16-24(32)30-7-9-36-10-8-30/h3-6,11-15,28H,7-10,16H2,1-2H3
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n/an/a 2n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluorescence reson...


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347658
PNG
(CHEMBL1802917)
Show SMILES CN(C[C@@H]1COCCO1)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(c1)C1CCNCC1 |r|
Show InChI InChI=1S/C28H32N6O5S/c1-33(17-24-18-38-10-11-39-24)40(36,37)32-22-4-2-19-3-5-27-26(28(35)25(19)13-22)12-20(14-30-27)21-15-31-34(16-21)23-6-8-29-9-7-23/h2-5,12-16,23-24,29,32H,6-11,17-18H2,1H3/t24-/m1/s1
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n/an/a 2.60n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluorescence reson...


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347677
PNG
(CHEMBL1802833)
Show SMILES CN(C)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(CCCO)c1
Show InChI InChI=1S/C22H23N5O4S/c1-26(2)32(30,31)25-18-6-4-15-5-7-21-20(22(29)19(15)11-18)10-16(12-23-21)17-13-24-27(14-17)8-3-9-28/h4-7,10-14,25,28H,3,8-9H2,1-2H3
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n/an/a 3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluorescence reson...


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347674
PNG
(CHEMBL1802836)
Show SMILES COCC(F)Cn1cc(cn1)-c1cnc2ccc3ccc(NS(=O)(=O)N(C)C)cc3c(=O)c2c1
Show InChI InChI=1S/C23H24FN5O4S/c1-28(2)34(31,32)27-19-6-4-15-5-7-22-21(23(30)20(15)9-19)8-16(10-25-22)17-11-26-29(12-17)13-18(24)14-33-3/h4-12,18,27H,13-14H2,1-3H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluorescence reson...


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347662
PNG
(CHEMBL1802913)
Show SMILES COCCCN(C)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1
Show InChI InChI=1S/C23H25N5O4S/c1-27-15-18(14-25-27)17-11-21-22(24-13-17)8-6-16-5-7-19(12-20(16)23(21)29)26-33(30,31)28(2)9-4-10-32-3/h5-8,11-15,26H,4,9-10H2,1-3H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluorescence reson...


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347676
PNG
(CHEMBL1802834)
Show SMILES CN(C)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(CCF)c1
Show InChI InChI=1S/C21H20FN5O3S/c1-26(2)31(29,30)25-17-5-3-14-4-6-20-19(21(28)18(14)10-17)9-15(11-23-20)16-12-24-27(13-16)8-7-22/h3-6,9-13,25H,7-8H2,1-2H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluorescence reson...


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347670
PNG
(CHEMBL1802906)
Show SMILES Cn1cc(cn1)-c1cnc2ccc3ccc(NS(N)(=O)=O)cc3c(=O)c2c1
Show InChI InChI=1S/C18H15N5O3S/c1-23-10-13(9-21-23)12-6-16-17(20-8-12)5-3-11-2-4-14(22-27(19,25)26)7-15(11)18(16)24/h2-10,22H,1H3,(H2,19,25,26)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluorescence reson...


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347681
PNG
(CHEMBL1802829)
Show SMILES CN(C)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1
Show InChI InChI=1S/C20H19N5O3S/c1-24(2)29(27,28)23-16-6-4-13-5-7-19-18(20(26)17(13)9-16)8-14(10-21-19)15-11-22-25(3)12-15/h4-12,23H,1-3H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluorescence reson...


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347686
PNG
(CHEMBL1802602)
Show SMILES Cn1cc(cn1)-c1cnc2ccc3ccc(NS(C)(=O)=O)cc3c(=O)c2c1
Show InChI InChI=1S/C19H16N4O3S/c1-23-11-14(10-21-23)13-7-17-18(20-9-13)6-4-12-3-5-15(22-27(2,25)26)8-16(12)19(17)24/h3-11,22H,1-2H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluorescence reson...


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347668
PNG
(CHEMBL1802908)
Show SMILES CCN(CC)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1
Show InChI InChI=1S/C22H23N5O3S/c1-4-27(5-2)31(29,30)25-18-8-6-15-7-9-21-20(22(28)19(15)11-18)10-16(12-23-21)17-13-24-26(3)14-17/h6-14,25H,4-5H2,1-3H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluorescence reson...


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347678
PNG
(CHEMBL1802832)
Show SMILES CN(C)CCCn1cc(cn1)-c1cnc2ccc3ccc(NS(=O)(=O)N(C)C)cc3c(=O)c2c1
Show InChI InChI=1S/C24H28N6O3S/c1-28(2)10-5-11-30-16-19(15-26-30)18-12-22-23(25-14-18)9-7-17-6-8-20(13-21(17)24(22)31)27-34(32,33)29(3)4/h6-9,12-16,27H,5,10-11H2,1-4H3
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n/an/a 4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluorescence reson...


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347663
PNG
(CHEMBL1802912)
Show SMILES Cn1cc(cn1)-c1cnc2ccc3ccc(NS(=O)(=O)N4CC(F)C4)cc3c(=O)c2c1
Show InChI InChI=1S/C21H18FN5O3S/c1-26-10-15(9-24-26)14-6-19-20(23-8-14)5-3-13-2-4-17(7-18(13)21(19)28)25-31(29,30)27-11-16(22)12-27/h2-10,16,25H,11-12H2,1H3
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n/an/a 5n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluorescence reson...


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347695
PNG
(CHEMBL1802605)
Show SMILES CNc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1
Show InChI InChI=1S/C19H16N4O/c1-20-15-5-3-12-4-6-18-17(19(24)16(12)8-15)7-13(9-21-18)14-10-22-23(2)11-14/h3-11,20H,1-2H3
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n/an/a 5n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluorescence reson...


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM50347659
PNG
(CHEMBL1802916 | MK-2461)
Show SMILES CN(C[C@@H]1COCCO1)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1 |r|
Show InChI InChI=1S/C24H25N5O5S/c1-28-13-18(12-26-28)17-9-22-23(25-11-17)6-4-16-3-5-19(10-21(16)24(22)30)27-35(31,32)29(2)14-20-15-33-7-8-34-20/h3-6,9-13,20,27H,7-8,14-15H2,1-2H3/t20-/m1/s1
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n/an/a 7n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human Ron


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347664
PNG
(CHEMBL1802911)
Show SMILES Cn1cc(cn1)-c1cnc2ccc3ccc(NS(=O)(=O)N4CCC4)cc3c(=O)c2c1
Show InChI InChI=1S/C21H19N5O3S/c1-25-13-16(12-23-25)15-9-19-20(22-11-15)6-4-14-3-5-17(10-18(14)21(19)27)24-30(28,29)26-7-2-8-26/h3-6,9-13,24H,2,7-8H2,1H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluorescence reson...


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50347659
PNG
(CHEMBL1802916 | MK-2461)
Show SMILES CN(C[C@@H]1COCCO1)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1 |r|
Show InChI InChI=1S/C24H25N5O5S/c1-28-13-18(12-26-28)17-9-22-23(25-11-17)6-4-16-3-5-19(10-21(16)24(22)30)27-35(31,32)29(2)14-20-15-33-7-8-34-20/h3-6,9-13,20,27H,7-8,14-15H2,1-2H3/t20-/m1/s1
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n/an/a 10n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human Flt1


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347700
PNG
(CHEMBL1802599)
Show SMILES CS(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1ccsc1
Show InChI InChI=1S/C19H14N2O3S2/c1-26(23,24)21-15-4-2-12-3-5-18-17(19(22)16(12)9-15)8-14(10-20-18)13-6-7-25-11-13/h2-11,21H,1H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluorescence reson...


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347694
PNG
(CHEMBL1802606)
Show SMILES Cn1cc(cn1)-c1cnc2ccc3ccc(O)cc3c(=O)c2c1
Show InChI InChI=1S/C18H13N3O2/c1-21-10-13(9-20-21)12-6-16-17(19-8-12)5-3-11-2-4-14(22)7-15(11)18(16)23/h2-10,22H,1H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluorescence reson...


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347686
PNG
(CHEMBL1802602)
Show SMILES Cn1cc(cn1)-c1cnc2ccc3ccc(NS(C)(=O)=O)cc3c(=O)c2c1
Show InChI InChI=1S/C19H16N4O3S/c1-23-11-14(10-21-23)13-7-17-18(20-9-13)6-4-12-3-5-15(22-27(2,25)26)8-16(12)19(17)24/h3-11,22H,1-2H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-MET overexpressed in human GTL-16 cells assessed as phosphorylation at C-terminal Y1349 after 2 hrs by Western blot analysis


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347670
PNG
(CHEMBL1802906)
Show SMILES Cn1cc(cn1)-c1cnc2ccc3ccc(NS(N)(=O)=O)cc3c(=O)c2c1
Show InChI InChI=1S/C18H15N5O3S/c1-23-10-13(9-21-23)12-6-16-17(20-8-12)5-3-11-2-4-14(22-27(19,25)26)7-15(11)18(16)24/h2-10,22H,1H3,(H2,19,25,26)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-MET overexpressed in human GTL-16 cells assessed as phosphorylation at C-terminal Y1349 after 2 hrs by Western blot analysis


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347673
PNG
(CHEMBL1802903)
Show SMILES CN(C)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(CC(F)CN2CCCC2)c1
Show InChI InChI=1S/C26H29FN6O3S/c1-31(2)37(35,36)30-22-7-5-18-6-8-25-24(26(34)23(18)12-22)11-19(13-28-25)20-14-29-33(15-20)17-21(27)16-32-9-3-4-10-32/h5-8,11-15,21,30H,3-4,9-10,16-17H2,1-2H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-MET overexpressed in human GTL-16 cells assessed as phosphorylation at C-terminal Y1349 after 2 hrs by Western blot analysis


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347669
PNG
(CHEMBL1802907)
Show SMILES CNS(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1
Show InChI InChI=1S/C19H17N5O3S/c1-20-28(26,27)23-15-5-3-12-4-6-18-17(19(25)16(12)8-15)7-13(9-21-18)14-10-22-24(2)11-14/h3-11,20,23H,1-2H3
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n/an/a 12n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-MET overexpressed in human GTL-16 cells assessed as phosphorylation at C-terminal Y1349 after 2 hrs by Western blot analysis


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347687
PNG
(CHEMBL1802828)
Show SMILES Cn1cc(cn1)-c1cnc2ccc3ccc(NS(=O)(=O)CCn4ccnc4)cc3c(=O)c2c1
Show InChI InChI=1S/C23H20N6O3S/c1-28-14-18(13-26-28)17-10-21-22(25-12-17)5-3-16-2-4-19(11-20(16)23(21)30)27-33(31,32)9-8-29-7-6-24-15-29/h2-7,10-15,27H,8-9H2,1H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluorescence reson...


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347699
PNG
(CHEMBL1802600)
Show SMILES CS(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnsc1
Show InChI InChI=1S/C18H13N3O3S2/c1-26(23,24)21-14-4-2-11-3-5-17-16(18(22)15(11)7-14)6-12(8-19-17)13-9-20-25-10-13/h2-10,21H,1H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluorescence reson...


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347660
PNG
(CHEMBL1802915)
Show SMILES CN(C[C@H]1COCCO1)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1 |r|
Show InChI InChI=1S/C24H25N5O5S/c1-28-13-18(12-26-28)17-9-22-23(25-11-17)6-4-16-3-5-19(10-21(16)24(22)30)27-35(31,32)29(2)14-20-15-33-7-8-34-20/h3-6,9-13,20,27H,7-8,14-15H2,1-2H3/t20-/m0/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluorescence reson...


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347650
PNG
(CHEMBL1802591)
Show SMILES CS(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)N1CCN(CC1)c1cccnc1
Show InChI InChI=1S/C24H23N5O3S/c1-33(31,32)27-18-6-4-17-5-7-23-22(24(30)21(17)13-18)14-20(16-26-23)29-11-9-28(10-12-29)19-3-2-8-25-15-19/h2-8,13-16,27H,9-12H2,1H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluorescence reson...


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347696
PNG
(CHEMBL1802604)
Show SMILES Cn1cc(cn1)-c1cnc2ccc3ccc(N)c(Cl)c3c(=O)c2c1
Show InChI InChI=1S/C18H13ClN4O/c1-23-9-12(8-22-23)11-6-13-15(21-7-11)5-3-10-2-4-14(20)17(19)16(10)18(13)24/h2-9H,20H2,1H3
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n/an/a 19n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluorescence reson...


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347674
PNG
(CHEMBL1802836)
Show SMILES COCC(F)Cn1cc(cn1)-c1cnc2ccc3ccc(NS(=O)(=O)N(C)C)cc3c(=O)c2c1
Show InChI InChI=1S/C23H24FN5O4S/c1-28(2)34(31,32)27-19-6-4-15-5-7-22-21(23(30)20(15)9-19)8-16(10-25-22)17-11-26-29(12-17)13-18(24)14-33-3/h4-12,18,27H,13-14H2,1-3H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-MET overexpressed in human GTL-16 cells assessed as phosphorylation at C-terminal Y1349 after 2 hrs by Western blot analysis


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50347659
PNG
(CHEMBL1802916 | MK-2461)
Show SMILES CN(C[C@@H]1COCCO1)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1 |r|
Show InChI InChI=1S/C24H25N5O5S/c1-28-13-18(12-26-28)17-9-22-23(25-11-17)6-4-16-3-5-19(10-21(16)24(22)30)27-35(31,32)29(2)14-20-15-33-7-8-34-20/h3-6,9-13,20,27H,7-8,14-15H2,1-2H3/t20-/m1/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human Flt3


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347651
PNG
(CHEMBL1802590)
Show SMILES CS(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)N1CCC2(CC1)OCCO2
Show InChI InChI=1S/C22H23N3O5S/c1-31(27,28)24-16-4-2-15-3-5-20-19(21(26)18(15)12-16)13-17(14-23-20)25-8-6-22(7-9-25)29-10-11-30-22/h2-5,12-14,24H,6-11H2,1H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluorescence reson...


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM50347659
PNG
(CHEMBL1802916 | MK-2461)
Show SMILES CN(C[C@@H]1COCCO1)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1 |r|
Show InChI InChI=1S/C24H25N5O5S/c1-28-13-18(12-26-28)17-9-22-23(25-11-17)6-4-16-3-5-19(10-21(16)24(22)30)27-35(31,32)29(2)14-20-15-33-7-8-34-20/h3-6,9-13,20,27H,7-8,14-15H2,1-2H3/t20-/m1/s1
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n/an/a 24n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human Mer


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347659
PNG
(CHEMBL1802916 | MK-2461)
Show SMILES CN(C[C@@H]1COCCO1)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1 |r|
Show InChI InChI=1S/C24H25N5O5S/c1-28-13-18(12-26-28)17-9-22-23(25-11-17)6-4-16-3-5-19(10-21(16)24(22)30)27-35(31,32)29(2)14-20-15-33-7-8-34-20/h3-6,9-13,20,27H,7-8,14-15H2,1-2H3/t20-/m1/s1
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n/an/a 26n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of recombinant human c-MET phosphorylation at C-terminal Y1365


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347693
PNG
(CHEMBL1802822)
Show SMILES CCS(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1ccccc1
Show InChI InChI=1S/C22H18N2O3S/c1-2-28(26,27)24-18-10-8-16-9-11-21-20(22(25)19(16)13-18)12-17(14-23-21)15-6-4-3-5-7-15/h3-14,24H,2H2,1H3
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n/an/a 27n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluorescence reson...


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347677
PNG
(CHEMBL1802833)
Show SMILES CN(C)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(CCCO)c1
Show InChI InChI=1S/C22H23N5O4S/c1-26(2)32(30,31)25-18-6-4-15-5-7-21-20(22(29)19(15)11-18)10-16(12-23-21)17-13-24-27(14-17)8-3-9-28/h4-7,10-14,25,28H,3,8-9H2,1-2H3
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n/an/a 27n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-MET overexpressed in human GTL-16 cells assessed as phosphorylation at C-terminal Y1349 after 2 hrs by Western blot analysis


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347663
PNG
(CHEMBL1802912)
Show SMILES Cn1cc(cn1)-c1cnc2ccc3ccc(NS(=O)(=O)N4CC(F)C4)cc3c(=O)c2c1
Show InChI InChI=1S/C21H18FN5O3S/c1-26-10-15(9-24-26)14-6-19-20(23-8-14)5-3-13-2-4-17(7-18(13)21(19)28)25-31(29,30)27-11-16(22)12-27/h2-10,16,25H,11-12H2,1H3
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n/an/a 28n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-MET overexpressed in human GTL-16 cells assessed as phosphorylation at C-terminal Y1349 after 2 hrs by Western blot analysis


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347657
PNG
(CHEMBL1615181)
Show SMILES O=C(CCc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(c1)C1CCNCC1)NCc1ccccn1
Show InChI InChI=1S/C31H30N6O2/c38-30(35-19-25-3-1-2-12-33-25)9-5-21-4-6-22-7-8-29-28(31(39)27(22)15-21)16-23(17-34-29)24-18-36-37(20-24)26-10-13-32-14-11-26/h1-4,6-8,12,15-18,20,26,32H,5,9-11,13-14,19H2,(H,35,38)
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n/an/a 28n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluorescence reson...


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347646
PNG
(CHEMBL1802595)
Show SMILES CS(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1ccncc1
Show InChI InChI=1S/C20H15N3O3S/c1-27(25,26)23-16-4-2-14-3-5-19-18(20(24)17(14)11-16)10-15(12-22-19)13-6-8-21-9-7-13/h2-12,23H,1H3
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n/an/a 30n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluorescence reson...


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347666
PNG
(CHEMBL1802910)
Show SMILES CN(Cc1ccccc1)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1
Show InChI InChI=1S/C26H23N5O3S/c1-30-17-21(15-28-30)20-12-24-25(27-14-20)11-9-19-8-10-22(13-23(19)26(24)32)29-35(33,34)31(2)16-18-6-4-3-5-7-18/h3-15,17,29H,16H2,1-2H3
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n/an/a 30n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluorescence reson...


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347689
PNG
(CHEMBL1802826)
Show SMILES Cn1cc(cn1)-c1cnc2ccc3ccc(NS(=O)(=O)C(C)(C)C)cc3c(=O)c2c1
Show InChI InChI=1S/C22H22N4O3S/c1-22(2,3)30(28,29)25-17-7-5-14-6-8-20-19(21(27)18(14)10-17)9-15(11-23-20)16-12-24-26(4)13-16/h5-13,25H,1-4H3
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n/an/a 31n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluorescence reson...


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347656
PNG
(CHEMBL1803004)
Show SMILES CS(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1ccccc1
Show InChI InChI=1S/C21H16N2O3S/c1-27(25,26)23-17-9-7-15-8-10-20-19(21(24)18(15)12-17)11-16(13-22-20)14-5-3-2-4-6-14/h2-13,23H,1H3
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n/an/a 31n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluore...


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347656
PNG
(CHEMBL1803004)
Show SMILES CS(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1ccccc1
Show InChI InChI=1S/C21H16N2O3S/c1-27(25,26)23-17-9-7-15-8-10-20-19(21(24)18(15)12-17)11-16(13-22-20)14-5-3-2-4-6-14/h2-13,23H,1H3
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n/an/a 31n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluorescence reson...


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347652
PNG
(CHEMBL1802589)
Show SMILES CC(C)N1CCN(CC1)c1cnc2ccc3ccc(NS(C)(=O)=O)cc3c(=O)c2c1
Show InChI InChI=1S/C22H26N4O3S/c1-15(2)25-8-10-26(11-9-25)18-13-20-21(23-14-18)7-5-16-4-6-17(24-30(3,28)29)12-19(16)22(20)27/h4-7,12-15,24H,8-11H2,1-3H3
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n/an/a 32n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluorescence reson...


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM50347659
PNG
(CHEMBL1802916 | MK-2461)
Show SMILES CN(C[C@@H]1COCCO1)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1 |r|
Show InChI InChI=1S/C24H25N5O5S/c1-28-13-18(12-26-28)17-9-22-23(25-11-17)6-4-16-3-5-19(10-21(16)24(22)30)27-35(31,32)29(2)14-20-15-33-7-8-34-20/h3-6,9-13,20,27H,7-8,14-15H2,1-2H3/t20-/m1/s1
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n/an/a 39n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human FGFR2


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347676
PNG
(CHEMBL1802834)
Show SMILES CN(C)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(CCF)c1
Show InChI InChI=1S/C21H20FN5O3S/c1-26(2)31(29,30)25-17-5-3-14-4-6-20-19(21(28)18(14)10-17)9-15(11-23-20)16-12-24-27(13-16)8-7-22/h3-6,9-13,25H,7-8H2,1-2H3
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n/an/a 40n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-MET overexpressed in human GTL-16 cells assessed as phosphorylation at C-terminal Y1349 after 2 hrs by Western blot analysis


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50347659
PNG
(CHEMBL1802916 | MK-2461)
Show SMILES CN(C[C@@H]1COCCO1)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1 |r|
Show InChI InChI=1S/C24H25N5O5S/c1-28-13-18(12-26-28)17-9-22-23(25-11-17)6-4-16-3-5-19(10-21(16)24(22)30)27-35(31,32)29(2)14-20-15-33-7-8-34-20/h3-6,9-13,20,27H,7-8,14-15H2,1-2H3/t20-/m1/s1
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n/an/a 44n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human KDR


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347648
PNG
(CHEMBL1802593)
Show SMILES CS(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cccc(Cl)c1
Show InChI InChI=1S/C21H15ClN2O3S/c1-28(26,27)24-17-7-5-13-6-8-20-19(21(25)18(13)11-17)10-15(12-23-20)14-3-2-4-16(22)9-14/h2-12,24H,1H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluorescence reson...


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347647
PNG
(CHEMBL1802594)
Show SMILES CS(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C21H15ClN2O3S/c1-28(26,27)24-17-8-4-14-5-9-20-19(21(25)18(14)11-17)10-15(12-23-20)13-2-6-16(22)7-3-13/h2-12,24H,1H3
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n/an/a 46n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluorescence reson...


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM50347659
PNG
(CHEMBL1802916 | MK-2461)
Show SMILES CN(C[C@@H]1COCCO1)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1 |r|
Show InChI InChI=1S/C24H25N5O5S/c1-28-13-18(12-26-28)17-9-22-23(25-11-17)6-4-16-3-5-19(10-21(16)24(22)30)27-35(31,32)29(2)14-20-15-33-7-8-34-20/h3-6,9-13,20,27H,7-8,14-15H2,1-2H3/t20-/m1/s1
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n/an/a 46n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human TrkA


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347655
PNG
(CHEMBL1802586)
Show SMILES CS(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)N1CCOCC1
Show InChI InChI=1S/C19H19N3O4S/c1-27(24,25)21-14-4-2-13-3-5-18-17(19(23)16(13)10-14)11-15(12-20-18)22-6-8-26-9-7-22/h2-5,10-12,21H,6-9H2,1H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluorescence reson...


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347659
PNG
(CHEMBL1802916 | MK-2461)
Show SMILES CN(C[C@@H]1COCCO1)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1 |r|
Show InChI InChI=1S/C24H25N5O5S/c1-28-13-18(12-26-28)17-9-22-23(25-11-17)6-4-16-3-5-19(10-21(16)24(22)30)27-35(31,32)29(2)14-20-15-33-7-8-34-20/h3-6,9-13,20,27H,7-8,14-15H2,1-2H3/t20-/m1/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-MET overexpressed in human GTL-16 cells assessed as phosphorylation at C-terminal Y1365 after 2 hrs by Western blot analysis


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM50347659
PNG
(CHEMBL1802916 | MK-2461)
Show SMILES CN(C[C@@H]1COCCO1)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1 |r|
Show InChI InChI=1S/C24H25N5O5S/c1-28-13-18(12-26-28)17-9-22-23(25-11-17)6-4-16-3-5-19(10-21(16)24(22)30)27-35(31,32)29(2)14-20-15-33-7-8-34-20/h3-6,9-13,20,27H,7-8,14-15H2,1-2H3/t20-/m1/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human FGFR3


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347661
PNG
(CHEMBL1802914)
Show SMILES CN([C@H]1CCOC1)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1 |r|
Show InChI InChI=1S/C23H23N5O4S/c1-27-13-17(12-25-27)16-9-21-22(24-11-16)6-4-15-3-5-18(10-20(15)23(21)29)26-33(30,31)28(2)19-7-8-32-14-19/h3-6,9-13,19,26H,7-8,14H2,1-2H3/t19-/m0/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-MET overexpressed in human GTL-16 cells assessed as phosphorylation at C-terminal Y1349 after 2 hrs by Western blot analysis


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347659
PNG
(CHEMBL1802916 | MK-2461)
Show SMILES CN(C[C@@H]1COCCO1)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1 |r|
Show InChI InChI=1S/C24H25N5O5S/c1-28-13-18(12-26-28)17-9-22-23(25-11-17)6-4-16-3-5-19(10-21(16)24(22)30)27-35(31,32)29(2)14-20-15-33-7-8-34-20/h3-6,9-13,20,27H,7-8,14-15H2,1-2H3/t20-/m1/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-MET overexpressed in human GTL-16 cells assessed as phosphorylation at C-terminal Y1349 after 2 hrs by Western blot analysis


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347665
PNG
(CHEMBL1800104)
Show SMILES Cn1cc(cn1)-c1cnc2ccc3ccc(NS(=O)(=O)N4CCOCC4)cc3c(=O)c2c1
Show InChI InChI=1S/C22H21N5O4S/c1-26-14-17(13-24-26)16-10-20-21(23-12-16)5-3-15-2-4-18(11-19(15)22(20)28)25-32(29,30)27-6-8-31-9-7-27/h2-5,10-14,25H,6-9H2,1H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluorescence reson...


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347662
PNG
(CHEMBL1802913)
Show SMILES COCCCN(C)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1
Show InChI InChI=1S/C23H25N5O4S/c1-27-15-18(14-25-27)17-11-21-22(24-13-17)8-6-16-5-7-19(12-20(16)23(21)29)26-33(30,31)28(2)9-4-10-32-3/h5-8,11-15,26H,4,9-10H2,1-3H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-MET overexpressed in human GTL-16 cells assessed as phosphorylation at C-terminal Y1349 after 2 hrs by Western blot analysis


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor


(Homo sapiens (Human))
BDBM50347659
PNG
(CHEMBL1802916 | MK-2461)
Show SMILES CN(C[C@@H]1COCCO1)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1 |r|
Show InChI InChI=1S/C24H25N5O5S/c1-28-13-18(12-26-28)17-9-22-23(25-11-17)6-4-16-3-5-19(10-21(16)24(22)30)27-35(31,32)29(2)14-20-15-33-7-8-34-20/h3-6,9-13,20,27H,7-8,14-15H2,1-2H3/t20-/m1/s1
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n/an/a 61n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human TrkB


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347701
PNG
(CHEMBL1802598)
Show SMILES CS(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1ccoc1
Show InChI InChI=1S/C19H14N2O4S/c1-26(23,24)21-15-4-2-12-3-5-18-17(19(22)16(12)9-15)8-14(10-20-18)13-6-7-25-11-13/h2-11,21H,1H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluorescence reson...


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50347659
PNG
(CHEMBL1802916 | MK-2461)
Show SMILES CN(C[C@@H]1COCCO1)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1 |r|
Show InChI InChI=1S/C24H25N5O5S/c1-28-13-18(12-26-28)17-9-22-23(25-11-17)6-4-16-3-5-19(10-21(16)24(22)30)27-35(31,32)29(2)14-20-15-33-7-8-34-20/h3-6,9-13,20,27H,7-8,14-15H2,1-2H3/t20-/m1/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human FGFR1


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347664
PNG
(CHEMBL1802911)
Show SMILES Cn1cc(cn1)-c1cnc2ccc3ccc(NS(=O)(=O)N4CCC4)cc3c(=O)c2c1
Show InChI InChI=1S/C21H19N5O3S/c1-25-13-16(12-23-25)15-9-19-20(22-11-15)6-4-14-3-5-17(10-18(14)21(19)27)24-30(28,29)26-7-2-8-26/h3-6,9-13,24H,2,7-8H2,1H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-MET overexpressed in human GTL-16 cells assessed as phosphorylation at C-terminal Y1349 after 2 hrs by Western blot analysis


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347645
PNG
(CHEMBL1802596)
Show SMILES CS(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cccnc1
Show InChI InChI=1S/C20H15N3O3S/c1-27(25,26)23-16-6-4-13-5-7-19-18(20(24)17(13)10-16)9-15(12-22-19)14-3-2-8-21-11-14/h2-12,23H,1H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluorescence reson...


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347672
PNG
(CHEMBL1802904)
Show SMILES CCN1CCC(CC1)n1cc(cn1)-c1cnc2ccc3ccc(NS(=O)(=O)N(C)C)cc3c(=O)c2c1
Show InChI InChI=1S/C26H30N6O3S/c1-4-31-11-9-22(10-12-31)32-17-20(16-28-32)19-13-24-25(27-15-19)8-6-18-5-7-21(14-23(18)26(24)33)29-36(34,35)30(2)3/h5-8,13-17,22,29H,4,9-12H2,1-3H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-MET overexpressed in human GTL-16 cells assessed as phosphorylation at C-terminal Y1349 after 2 hrs by Western blot analysis


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347667
PNG
(CHEMBL1802909)
Show SMILES CN(Cc1cnccn1)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1
Show InChI InChI=1S/C24H21N7O3S/c1-30-14-18(12-28-30)17-9-22-23(27-11-17)6-4-16-3-5-19(10-21(16)24(22)32)29-35(33,34)31(2)15-20-13-25-7-8-26-20/h3-14,29H,15H2,1-2H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-MET overexpressed in human GTL-16 cells assessed as phosphorylation at C-terminal Y1349 after 2 hrs by Western blot analysis


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM50347659
PNG
(CHEMBL1802916 | MK-2461)
Show SMILES CN(C[C@@H]1COCCO1)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1 |r|
Show InChI InChI=1S/C24H25N5O5S/c1-28-13-18(12-26-28)17-9-22-23(25-11-17)6-4-16-3-5-19(10-21(16)24(22)30)27-35(31,32)29(2)14-20-15-33-7-8-34-20/h3-6,9-13,20,27H,7-8,14-15H2,1-2H3/t20-/m1/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human Flt4


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347681
PNG
(CHEMBL1802829)
Show SMILES CN(C)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1
Show InChI InChI=1S/C20H19N5O3S/c1-24(2)29(27,28)23-16-6-4-13-5-7-19-18(20(26)17(13)9-16)8-14(10-21-19)15-11-22-25(3)12-15/h4-12,23H,1-3H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-MET overexpressed in human GTL-16 cells assessed as phosphorylation at C-terminal Y1349 after 2 hrs by Western blot analysis


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347695
PNG
(CHEMBL1802605)
Show SMILES CNc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1
Show InChI InChI=1S/C19H16N4O/c1-20-15-5-3-12-4-6-18-17(19(24)16(12)8-15)7-13(9-21-18)14-10-22-23(2)11-14/h3-11,20H,1-2H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-MET overexpressed in human GTL-16 cells assessed as phosphorylation at C-terminal Y1349 after 2 hrs by Western blot analysis


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347675
PNG
(CHEMBL1802835)
Show SMILES CN(C)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(CC(F)CO)c1
Show InChI InChI=1S/C22H22FN5O4S/c1-27(2)33(31,32)26-18-5-3-14-4-6-21-20(22(30)19(14)8-18)7-15(9-24-21)16-10-25-28(11-16)12-17(23)13-29/h3-11,17,26,29H,12-13H2,1-2H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-MET overexpressed in human GTL-16 cells assessed as phosphorylation at C-terminal Y1349 after 2 hrs by Western blot analysis


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347653
PNG
(CHEMBL1802588)
Show SMILES CS(=O)(=O)Nc1ccc2ccc3ncc(NCC4CC4)cc3c(=O)c2c1
Show InChI InChI=1S/C19H19N3O3S/c1-26(24,25)22-14-6-4-13-5-7-18-17(19(23)16(13)8-14)9-15(11-21-18)20-10-12-2-3-12/h4-9,11-12,20,22H,2-3,10H2,1H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluorescence reson...


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347636
PNG
(CHEMBL1802585)
Show SMILES CS(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)N1CCCCC1
Show InChI InChI=1S/C20H21N3O3S/c1-27(25,26)22-15-7-5-14-6-8-19-18(20(24)17(14)11-15)12-16(13-21-19)23-9-3-2-4-10-23/h5-8,11-13,22H,2-4,9-10H2,1H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluorescence reson...


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347678
PNG
(CHEMBL1802832)
Show SMILES CN(C)CCCn1cc(cn1)-c1cnc2ccc3ccc(NS(=O)(=O)N(C)C)cc3c(=O)c2c1
Show InChI InChI=1S/C24H28N6O3S/c1-28(2)10-5-11-30-16-19(15-26-30)18-12-22-23(25-14-18)9-7-17-6-8-20(13-21(17)24(22)31)27-34(32,33)29(3)4/h6-9,12-16,27H,5,10-11H2,1-4H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-MET overexpressed in human GTL-16 cells assessed as phosphorylation at C-terminal Y1349 after 2 hrs by Western blot analysis


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347659
PNG
(CHEMBL1802916 | MK-2461)
Show SMILES CN(C[C@@H]1COCCO1)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1 |r|
Show InChI InChI=1S/C24H25N5O5S/c1-28-13-18(12-26-28)17-9-22-23(25-11-17)6-4-16-3-5-19(10-21(16)24(22)30)27-35(31,32)29(2)14-20-15-33-7-8-34-20/h3-6,9-13,20,27H,7-8,14-15H2,1-2H3/t20-/m1/s1
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n/an/a 100n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of recombinant human c-MET phosphorylation at C-terminal Y1349


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347690
PNG
(CHEMBL1802825)
Show SMILES Cn1cnc(c1)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1
Show InChI InChI=1S/C22H18N6O3S/c1-27-12-21(24-13-27)32(30,31)26-17-5-3-14-4-6-20-19(22(29)18(14)8-17)7-15(9-23-20)16-10-25-28(2)11-16/h3-13,26H,1-2H3
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n/an/a 100n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluorescence reson...


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347668
PNG
(CHEMBL1802908)
Show SMILES CCN(CC)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1
Show InChI InChI=1S/C22H23N5O3S/c1-4-27(5-2)31(29,30)25-18-8-6-15-7-9-21-20(22(28)19(15)11-18)10-16(12-23-21)17-13-24-26(3)14-17/h6-14,25H,4-5H2,1-3H3
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n/an/a 110n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-MET overexpressed in human GTL-16 cells assessed as phosphorylation at C-terminal Y1349 after 2 hrs by Western blot analysis


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347697
PNG
(CHEMBL1802603)
Show SMILES Cn1cc(cn1)-c1cnc2ccc3ccc(N)cc3c(=O)c2c1
Show InChI InChI=1S/C18H14N4O/c1-22-10-13(9-21-22)12-6-16-17(20-8-12)5-3-11-2-4-14(19)7-15(11)18(16)23/h2-10H,19H2,1H3
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n/an/a 110n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-MET overexpressed in human GTL-16 cells assessed as phosphorylation at C-terminal Y1349 after 2 hrs by Western blot analysis


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347692
PNG
(CHEMBL1802823)
Show SMILES C=CS(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1ccccc1
Show InChI InChI=1S/C22H16N2O3S/c1-2-28(26,27)24-18-10-8-16-9-11-21-20(22(25)19(16)13-18)12-17(14-23-21)15-6-4-3-5-7-15/h2-14,24H,1H2
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n/an/a 130n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluorescence reson...


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347671
PNG
(CHEMBL1802905)
Show SMILES CN(C)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(c1)-c1ccccn1
Show InChI InChI=1S/C24H20N6O3S/c1-29(2)34(32,33)28-19-8-6-16-7-9-22-21(24(31)20(16)12-19)11-17(13-26-22)18-14-27-30(15-18)23-5-3-4-10-25-23/h3-15,28H,1-2H3
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n/an/a 130n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluorescence reson...


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347652
PNG
(CHEMBL1802589)
Show SMILES CC(C)N1CCN(CC1)c1cnc2ccc3ccc(NS(C)(=O)=O)cc3c(=O)c2c1
Show InChI InChI=1S/C22H26N4O3S/c1-15(2)25-8-10-26(11-9-25)18-13-20-21(23-14-18)7-5-16-4-6-17(24-30(3,28)29)12-19(16)22(20)27/h4-7,12-15,24H,8-11H2,1-3H3
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n/an/a 140n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-MET overexpressed in human GTL-16 cells assessed as phosphorylation at C-terminal Y1349 after 2 hrs by Western blot analysis


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347698
PNG
(CHEMBL1802601)
Show SMILES CS(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cn[nH]c1
Show InChI InChI=1S/C18H14N4O3S/c1-26(24,25)22-14-4-2-11-3-5-17-16(18(23)15(11)7-14)6-12(8-19-17)13-9-20-21-10-13/h2-10,22H,1H3,(H,20,21)
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n/an/a 170n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluorescence reson...


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347702
PNG
(CHEMBL1802597)
Show SMILES CS(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cncnc1
Show InChI InChI=1S/C19H14N4O3S/c1-27(25,26)23-15-4-2-12-3-5-18-17(19(24)16(12)7-15)6-13(10-22-18)14-8-20-11-21-9-14/h2-11,23H,1H3
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n/an/a 180n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluorescence reson...


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347660
PNG
(CHEMBL1802915)
Show SMILES CN(C[C@H]1COCCO1)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1 |r|
Show InChI InChI=1S/C24H25N5O5S/c1-28-13-18(12-26-28)17-9-22-23(25-11-17)6-4-16-3-5-19(10-21(16)24(22)30)27-35(31,32)29(2)14-20-15-33-7-8-34-20/h3-6,9-13,20,27H,7-8,14-15H2,1-2H3/t20-/m0/s1
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n/an/a 210n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-MET overexpressed in human GTL-16 cells assessed as phosphorylation at C-terminal Y1349 after 2 hrs by Western blot analysis


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347699
PNG
(CHEMBL1802600)
Show SMILES CS(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnsc1
Show InChI InChI=1S/C18H13N3O3S2/c1-26(23,24)21-14-4-2-11-3-5-17-16(18(22)15(11)7-14)6-12(8-19-17)13-9-20-25-10-13/h2-10,21H,1H3
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n/an/a 210n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-MET overexpressed in human GTL-16 cells assessed as phosphorylation at C-terminal Y1349 after 2 hrs by Western blot analysis


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347656
PNG
(CHEMBL1803004)
Show SMILES CS(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1ccccc1
Show InChI InChI=1S/C21H16N2O3S/c1-27(25,26)23-17-9-7-15-8-10-20-19(21(24)18(15)12-17)11-16(13-22-20)14-5-3-2-4-6-14/h2-13,23H,1H3
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n/an/a 220n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluore...


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50347659
PNG
(CHEMBL1802916 | MK-2461)
Show SMILES CN(C[C@@H]1COCCO1)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1 |r|
Show InChI InChI=1S/C24H25N5O5S/c1-28-13-18(12-26-28)17-9-22-23(25-11-17)6-4-16-3-5-19(10-21(16)24(22)30)27-35(31,32)29(2)14-20-15-33-7-8-34-20/h3-6,9-13,20,27H,7-8,14-15H2,1-2H3/t20-/m1/s1
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n/an/a 230n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human JAK2


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347649
PNG
(CHEMBL1802592)
Show SMILES CS(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1ccccc1Cl
Show InChI InChI=1S/C21H15ClN2O3S/c1-28(26,27)24-15-8-6-13-7-9-20-18(21(25)17(13)11-15)10-14(12-23-20)16-4-2-3-5-19(16)22/h2-12,24H,1H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluorescence reson...


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347679
PNG
(CHEMBL1802831)
Show SMILES CN(C)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(CC(=O)N2CCOCC2)c1
Show InChI InChI=1S/C25H26N6O5S/c1-29(2)37(34,35)28-20-5-3-17-4-6-23-22(25(33)21(17)12-20)11-18(13-26-23)19-14-27-31(15-19)16-24(32)30-7-9-36-10-8-30/h3-6,11-15,28H,7-10,16H2,1-2H3
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n/an/a 290n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-MET overexpressed in human GTL-16 cells assessed as phosphorylation at C-terminal Y1349 after 2 hrs by Western blot analysis


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM50347659
PNG
(CHEMBL1802916 | MK-2461)
Show SMILES CN(C[C@@H]1COCCO1)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1 |r|
Show InChI InChI=1S/C24H25N5O5S/c1-28-13-18(12-26-28)17-9-22-23(25-11-17)6-4-16-3-5-19(10-21(16)24(22)30)27-35(31,32)29(2)14-20-15-33-7-8-34-20/h3-6,9-13,20,27H,7-8,14-15H2,1-2H3/t20-/m1/s1
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n/an/a 290n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human Aurora A


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50347656
PNG
(CHEMBL1803004)
Show SMILES CS(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1ccccc1
Show InChI InChI=1S/C21H16N2O3S/c1-27(25,26)23-17-9-7-15-8-10-20-19(21(24)18(15)12-17)11-16(13-22-20)14-5-3-2-4-6-14/h2-13,23H,1H3
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n/an/a 290n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Kv11.1 channel


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347696
PNG
(CHEMBL1802604)
Show SMILES Cn1cc(cn1)-c1cnc2ccc3ccc(N)c(Cl)c3c(=O)c2c1
Show InChI InChI=1S/C18H13ClN4O/c1-23-9-12(8-22-23)11-6-13-15(21-7-11)5-3-10-2-4-14(20)17(19)16(10)18(13)24/h2-9H,20H2,1H3
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n/an/a 360n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-MET overexpressed in human GTL-16 cells assessed as phosphorylation at C-terminal Y1349 after 2 hrs by Western blot analysis


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347694
PNG
(CHEMBL1802606)
Show SMILES Cn1cc(cn1)-c1cnc2ccc3ccc(O)cc3c(=O)c2c1
Show InChI InChI=1S/C18H13N3O2/c1-21-10-13(9-20-21)12-6-16-17(19-8-12)5-3-11-2-4-14(22)7-15(11)18(16)23/h2-10,22H,1H3
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n/an/a 370n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-MET overexpressed in human GTL-16 cells assessed as phosphorylation at C-terminal Y1349 after 2 hrs by Western blot analysis


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347641
PNG
(CHEMBL1803011)
Show SMILES CS(=O)(=O)Nc1ccc2ccc3ncc(Cl)cc3c(=O)c2c1
Show InChI InChI=1S/C15H11ClN2O3S/c1-22(20,21)18-11-4-2-9-3-5-14-13(6-10(16)8-17-14)15(19)12(9)7-11/h2-8,18H,1H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluorescence reson...


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347691
PNG
(CHEMBL1802824)
Show SMILES O=c1c2cc(NS(=O)(=O)c3ccccc3)ccc2ccc2ncc(cc12)-c1ccccc1
Show InChI InChI=1S/C26H18N2O3S/c29-26-23-16-21(28-32(30,31)22-9-5-2-6-10-22)13-11-19(23)12-14-25-24(26)15-20(17-27-25)18-7-3-1-4-8-18/h1-17,28H
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluorescence reson...


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347654
PNG
(CHEMBL1802587)
Show SMILES CCCCN(C)c1cnc2ccc3ccc(NS(C)(=O)=O)cc3c(=O)c2c1
Show InChI InChI=1S/C20H23N3O3S/c1-4-5-10-23(2)16-12-18-19(21-13-16)9-7-14-6-8-15(22-27(3,25)26)11-17(14)20(18)24/h6-9,11-13,22H,4-5,10H2,1-3H3
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n/an/a 440n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluorescence reson...


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347689
PNG
(CHEMBL1802826)
Show SMILES Cn1cc(cn1)-c1cnc2ccc3ccc(NS(=O)(=O)C(C)(C)C)cc3c(=O)c2c1
Show InChI InChI=1S/C22H22N4O3S/c1-22(2,3)30(28,29)25-17-7-5-14-6-8-20-19(21(27)18(14)10-17)9-15(11-23-20)16-12-24-26(4)13-16/h5-13,25H,1-4H3
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n/an/a 580n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-MET overexpressed in human GTL-16 cells assessed as phosphorylation at C-terminal Y1349 after 2 hrs by Western blot analysis


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM50347659
PNG
(CHEMBL1802916 | MK-2461)
Show SMILES CN(C[C@@H]1COCCO1)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1 |r|
Show InChI InChI=1S/C24H25N5O5S/c1-28-13-18(12-26-28)17-9-22-23(25-11-17)6-4-16-3-5-19(10-21(16)24(22)30)27-35(31,32)29(2)14-20-15-33-7-8-34-20/h3-6,9-13,20,27H,7-8,14-15H2,1-2H3/t20-/m1/s1
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n/an/a 640n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human Ret


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347671
PNG
(CHEMBL1802905)
Show SMILES CN(C)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(c1)-c1ccccn1
Show InChI InChI=1S/C24H20N6O3S/c1-29(2)34(32,33)28-19-8-6-16-7-9-22-21(24(31)20(16)12-19)11-17(13-26-22)18-14-27-30(15-18)23-5-3-4-10-25-23/h3-15,28H,1-2H3
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n/an/a 750n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-MET overexpressed in human GTL-16 cells assessed as phosphorylation at C-terminal Y1349 after 2 hrs by Western blot analysis


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347646
PNG
(CHEMBL1802595)
Show SMILES CS(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1ccncc1
Show InChI InChI=1S/C20H15N3O3S/c1-27(25,26)23-16-4-2-14-3-5-19-18(20(24)17(14)11-16)10-15(12-22-19)13-6-8-21-9-7-13/h2-12,23H,1H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-MET overexpressed in human GTL-16 cells assessed as phosphorylation at C-terminal Y1349 after 2 hrs by Western blot analysis


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347653
PNG
(CHEMBL1802588)
Show SMILES CS(=O)(=O)Nc1ccc2ccc3ncc(NCC4CC4)cc3c(=O)c2c1
Show InChI InChI=1S/C19H19N3O3S/c1-26(24,25)22-14-6-4-13-5-7-18-17(19(23)16(13)8-14)9-15(11-21-18)20-10-12-2-3-12/h4-9,11-12,20,22H,2-3,10H2,1H3
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n/an/a 760n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-MET overexpressed in human GTL-16 cells assessed as phosphorylation at C-terminal Y1349 after 2 hrs by Western blot analysis


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347682
PNG
(CHEMBL1803008)
Show SMILES CS(=O)(=O)Nc1ccc2C=Cc3ncc(cc3C(N3CCCC3)c2c1)-c1ccccc1 |c:9|
Show InChI InChI=1S/C25H25N3O2S/c1-31(29,30)27-21-11-9-19-10-12-24-23(25(22(19)16-21)28-13-5-6-14-28)15-20(17-26-24)18-7-3-2-4-8-18/h2-4,7-12,15-17,25,27H,5-6,13-14H2,1H3
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n/an/a 770n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluorescence reson...


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347642
PNG
(CHEMBL1803010)
Show SMILES CN(c1ccc2ccc3ncc(cc3c(=O)c2c1)-c1ccccc1)S(C)(=O)=O
Show InChI InChI=1S/C22H18N2O3S/c1-24(28(2,26)27)18-10-8-16-9-11-21-20(22(25)19(16)13-18)12-17(14-23-21)15-6-4-3-5-7-15/h3-14H,1-2H3
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n/an/a 780n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluorescence reson...


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347651
PNG
(CHEMBL1802590)
Show SMILES CS(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)N1CCC2(CC1)OCCO2
Show InChI InChI=1S/C22H23N3O5S/c1-31(27,28)24-16-4-2-15-3-5-20-19(21(26)18(15)12-16)13-17(14-23-20)25-8-6-22(7-9-25)29-10-11-30-22/h2-5,12-14,24H,6-11H2,1H3
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n/an/a 790n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-MET overexpressed in human GTL-16 cells assessed as phosphorylation at C-terminal Y1349 after 2 hrs by Western blot analysis


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347659
PNG
(CHEMBL1802916 | MK-2461)
Show SMILES CN(C[C@@H]1COCCO1)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1 |r|
Show InChI InChI=1S/C24H25N5O5S/c1-28-13-18(12-26-28)17-9-22-23(25-11-17)6-4-16-3-5-19(10-21(16)24(22)30)27-35(31,32)29(2)14-20-15-33-7-8-34-20/h3-6,9-13,20,27H,7-8,14-15H2,1-2H3/t20-/m1/s1
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n/an/a 900n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of recombinant human c-MET phosphorylation at C-terminal Y1230


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347659
PNG
(CHEMBL1802916 | MK-2461)
Show SMILES CN(C[C@@H]1COCCO1)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1 |r|
Show InChI InChI=1S/C24H25N5O5S/c1-28-13-18(12-26-28)17-9-22-23(25-11-17)6-4-16-3-5-19(10-21(16)24(22)30)27-35(31,32)29(2)14-20-15-33-7-8-34-20/h3-6,9-13,20,27H,7-8,14-15H2,1-2H3/t20-/m1/s1
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n/an/a 900n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of recombinant human c-MET phosphorylation at C-terminal Y1235


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347659
PNG
(CHEMBL1802916 | MK-2461)
Show SMILES CN(C[C@@H]1COCCO1)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1 |r|
Show InChI InChI=1S/C24H25N5O5S/c1-28-13-18(12-26-28)17-9-22-23(25-11-17)6-4-16-3-5-19(10-21(16)24(22)30)27-35(31,32)29(2)14-20-15-33-7-8-34-20/h3-6,9-13,20,27H,7-8,14-15H2,1-2H3/t20-/m1/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of recombinant human c-MET phosphorylation at C-terminal Y1234


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347665
PNG
(CHEMBL1800104)
Show SMILES Cn1cc(cn1)-c1cnc2ccc3ccc(NS(=O)(=O)N4CCOCC4)cc3c(=O)c2c1
Show InChI InChI=1S/C22H21N5O4S/c1-26-14-17(13-24-26)16-10-20-21(23-12-16)5-3-15-2-4-18(11-19(15)22(20)28)25-32(29,30)27-6-8-31-9-7-27/h2-5,10-14,25H,6-9H2,1H3
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n/an/a 1.00E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-MET overexpressed in human GTL-16 cells assessed as phosphorylation at C-terminal Y1349 after 2 hrs by Western blot analysis


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347644
PNG
(CHEMBL1803009)
Show SMILES Nc1cccc2ccc3ncc(cc3c(=O)c12)-c1ccccc1
Show InChI InChI=1S/C20H14N2O/c21-17-8-4-7-14-9-10-18-16(20(23)19(14)17)11-15(12-22-18)13-5-2-1-3-6-13/h1-12H,21H2
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n/an/a 1.10E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluorescence reson...


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347639
PNG
(CHEMBL1803013)
Show SMILES CS(=O)(=O)Nc1ccc2ccc3ncccc3c(=O)c2c1
Show InChI InChI=1S/C15H12N2O3S/c1-21(19,20)17-11-6-4-10-5-7-14-12(3-2-8-16-14)15(18)13(10)9-11/h2-9,17H,1H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluorescence reson...


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347636
PNG
(CHEMBL1802585)
Show SMILES CS(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)N1CCCCC1
Show InChI InChI=1S/C20H21N3O3S/c1-27(25,26)22-15-7-5-14-6-8-19-18(20(24)17(14)11-15)12-16(13-21-19)23-9-3-2-4-10-23/h5-8,11-13,22H,2-4,9-10H2,1H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-MET overexpressed in human GTL-16 cells assessed as phosphorylation at C-terminal Y1349 after 2 hrs by Western blot analysis


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Cytochrome P450 2C9


(Homo sapiens (Human))
BDBM50347659
PNG
(CHEMBL1802916 | MK-2461)
Show SMILES CN(C[C@@H]1COCCO1)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1 |r|
Show InChI InChI=1S/C24H25N5O5S/c1-28-13-18(12-26-28)17-9-22-23(25-11-17)6-4-16-3-5-19(10-21(16)24(22)30)27-35(31,32)29(2)14-20-15-33-7-8-34-20/h3-6,9-13,20,27H,7-8,14-15H2,1-2H3/t20-/m1/s1
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n/an/a 1.20E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of CYP2C9


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347666
PNG
(CHEMBL1802910)
Show SMILES CN(Cc1ccccc1)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1
Show InChI InChI=1S/C26H23N5O3S/c1-30-17-21(15-28-30)20-12-24-25(27-14-20)11-9-19-8-10-22(13-23(19)26(24)32)29-35(33,34)31(2)16-18-6-4-3-5-7-18/h3-15,17,29H,16H2,1-2H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-MET overexpressed in human GTL-16 cells assessed as phosphorylation at C-terminal Y1349 after 2 hrs by Western blot analysis


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347698
PNG
(CHEMBL1802601)
Show SMILES CS(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cn[nH]c1
Show InChI InChI=1S/C18H14N4O3S/c1-26(24,25)22-14-4-2-11-3-5-17-16(18(23)15(11)7-14)6-12(8-19-17)13-9-20-21-10-13/h2-10,22H,1H3,(H,20,21)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-MET overexpressed in human GTL-16 cells assessed as phosphorylation at C-terminal Y1349 after 2 hrs by Western blot analysis


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347693
PNG
(CHEMBL1802822)
Show SMILES CCS(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1ccccc1
Show InChI InChI=1S/C22H18N2O3S/c1-2-28(26,27)24-18-10-8-16-9-11-21-20(22(25)19(16)13-18)12-17(14-23-21)15-6-4-3-5-7-15/h3-14,24H,2H2,1H3
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n/an/a 1.50E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-MET overexpressed in human GTL-16 cells assessed as phosphorylation at C-terminal Y1349 after 2 hrs by Western blot analysis


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347700
PNG
(CHEMBL1802599)
Show SMILES CS(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1ccsc1
Show InChI InChI=1S/C19H14N2O3S2/c1-26(23,24)21-15-4-2-12-3-5-18-17(19(22)16(12)9-15)8-14(10-20-18)13-6-7-25-11-13/h2-11,21H,1H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-MET overexpressed in human GTL-16 cells assessed as phosphorylation at C-terminal Y1349 after 2 hrs by Western blot analysis


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347655
PNG
(CHEMBL1802586)
Show SMILES CS(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)N1CCOCC1
Show InChI InChI=1S/C19H19N3O4S/c1-27(24,25)21-14-4-2-13-3-5-18-17(19(23)16(13)10-14)11-15(12-20-18)22-6-8-26-9-7-22/h2-5,10-12,21H,6-9H2,1H3
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n/an/a 2.00E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-MET overexpressed in human GTL-16 cells assessed as phosphorylation at C-terminal Y1349 after 2 hrs by Western blot analysis


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347650
PNG
(CHEMBL1802591)
Show SMILES CS(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)N1CCN(CC1)c1cccnc1
Show InChI InChI=1S/C24H23N5O3S/c1-33(31,32)27-18-6-4-17-5-7-23-22(24(30)21(17)13-18)14-20(16-26-23)29-11-9-28(10-12-29)19-3-2-8-25-15-19/h2-8,13-16,27H,9-12H2,1H3
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n/an/a 2.00E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-MET overexpressed in human GTL-16 cells assessed as phosphorylation at C-terminal Y1349 after 2 hrs by Western blot analysis


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347685
PNG
(CHEMBL1803005)
Show SMILES CS(=O)(=O)Nc1ccc2CCc3ncc(cc3C(=O)c2c1)-c1ccccc1
Show InChI InChI=1S/C21H18N2O3S/c1-27(25,26)23-17-9-7-15-8-10-20-19(21(24)18(15)12-17)11-16(13-22-20)14-5-3-2-4-6-14/h2-7,9,11-13,23H,8,10H2,1H3
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n/an/a 2.30E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluorescence reson...


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347690
PNG
(CHEMBL1802825)
Show SMILES Cn1cnc(c1)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1
Show InChI InChI=1S/C22H18N6O3S/c1-27-12-21(24-13-27)32(30,31)26-17-5-3-14-4-6-20-19(22(29)18(14)8-17)7-15(9-23-20)16-10-25-28(2)11-16/h3-13,26H,1-2H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-MET overexpressed in human GTL-16 cells assessed as phosphorylation at C-terminal Y1349 after 2 hrs by Western blot analysis


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347645
PNG
(CHEMBL1802596)
Show SMILES CS(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cccnc1
Show InChI InChI=1S/C20H15N3O3S/c1-27(25,26)23-16-6-4-13-5-7-19-18(20(24)17(13)10-16)9-15(12-22-19)14-3-2-8-21-11-14/h2-12,23H,1H3
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n/an/a 2.50E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-MET overexpressed in human GTL-16 cells assessed as phosphorylation at C-terminal Y1349 after 2 hrs by Western blot analysis


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347659
PNG
(CHEMBL1802916 | MK-2461)
Show SMILES CN(C[C@@H]1COCCO1)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1 |r|
Show InChI InChI=1S/C24H25N5O5S/c1-28-13-18(12-26-28)17-9-22-23(25-11-17)6-4-16-3-5-19(10-21(16)24(22)30)27-35(31,32)29(2)14-20-15-33-7-8-34-20/h3-6,9-13,20,27H,7-8,14-15H2,1-2H3/t20-/m1/s1
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n/an/a>2.50E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-MET overexpressed in human GTL-16 cells assessed as phosphorylation at C-terminal Y1235 after 2 hrs by Western blot analysis


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347656
PNG
(CHEMBL1803004)
Show SMILES CS(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1ccccc1
Show InChI InChI=1S/C21H16N2O3S/c1-27(25,26)23-17-9-7-15-8-10-20-19(21(24)18(15)12-17)11-16(13-22-20)14-5-3-2-4-6-14/h2-13,23H,1H3
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n/an/a 2.50E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-MET overexpressed in human GTL-16 cells assessed as phosphorylation at C-terminal Y1349 after 2 hrs by Western blot analysis


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347659
PNG
(CHEMBL1802916 | MK-2461)
Show SMILES CN(C[C@@H]1COCCO1)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1 |r|
Show InChI InChI=1S/C24H25N5O5S/c1-28-13-18(12-26-28)17-9-22-23(25-11-17)6-4-16-3-5-19(10-21(16)24(22)30)27-35(31,32)29(2)14-20-15-33-7-8-34-20/h3-6,9-13,20,27H,7-8,14-15H2,1-2H3/t20-/m1/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-MET overexpressed in human GTL-16 cells assessed as phosphorylation at C-terminal Y1234 after 2 hrs by Western blot analysis


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347688
PNG
(CHEMBL1802827)
Show SMILES Cn1cc(cn1)-c1cnc2ccc3ccc(NS(=O)(=O)C(F)(F)F)cc3c(=O)c2c1
Show InChI InChI=1S/C19H13F3N4O3S/c1-26-10-13(9-24-26)12-6-16-17(23-8-12)5-3-11-2-4-14(7-15(11)18(16)27)25-30(28,29)19(20,21)22/h2-10,25H,1H3
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n/an/a 2.60E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluorescence reson...


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347683
PNG
(CHEMBL1803007)
Show SMILES CS(=O)(=O)Nc1ccc2C=Cc3ncc(cc3Cc2c1)-c1ccccc1 |c:9|
Show InChI InChI=1S/C21H18N2O2S/c1-26(24,25)23-20-9-7-16-8-10-21-18(11-17(16)13-20)12-19(14-22-21)15-5-3-2-4-6-15/h2-10,12-14,23H,11H2,1H3
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n/an/a 2.80E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluorescence reson...


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347637
PNG
(CHEMBL1803015)
Show SMILES CS(=O)(=O)Nc1ccc2ccc3[n+]([O-])cc(cc3c(=O)c2c1)-c1ccccc1
Show InChI InChI=1S/C21H16N2O4S/c1-28(26,27)22-17-9-7-15-8-10-20-19(21(24)18(15)12-17)11-16(13-23(20)25)14-5-3-2-4-6-14/h2-13,22H,1H3
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n/an/a 3.00E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluorescence reson...


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50347670
PNG
(CHEMBL1802906)
Show SMILES Cn1cc(cn1)-c1cnc2ccc3ccc(NS(N)(=O)=O)cc3c(=O)c2c1
Show InChI InChI=1S/C18H15N5O3S/c1-23-10-13(9-21-23)12-6-16-17(20-8-12)5-3-11-2-4-14(22-27(19,25)26)7-15(11)18(16)24/h2-10,22H,1H3,(H2,19,25,26)
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n/an/a 4.30E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Kv11.1 channel


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347648
PNG
(CHEMBL1802593)
Show SMILES CS(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cccc(Cl)c1
Show InChI InChI=1S/C21H15ClN2O3S/c1-28(26,27)24-17-7-5-13-6-8-20-19(21(25)18(13)11-17)10-15(12-23-20)14-3-2-4-16(22)9-14/h2-12,24H,1H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-MET overexpressed in human GTL-16 cells assessed as phosphorylation at C-terminal Y1349 after 2 hrs by Western blot analysis


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347647
PNG
(CHEMBL1802594)
Show SMILES CS(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C21H15ClN2O3S/c1-28(26,27)24-17-8-4-14-5-9-20-19(21(25)18(14)11-17)10-15(12-23-20)13-2-6-16(22)7-3-13/h2-12,24H,1H3
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n/an/a 5.40E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-MET overexpressed in human GTL-16 cells assessed as phosphorylation at C-terminal Y1349 after 2 hrs by Western blot analysis


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347688
PNG
(CHEMBL1802827)
Show SMILES Cn1cc(cn1)-c1cnc2ccc3ccc(NS(=O)(=O)C(F)(F)F)cc3c(=O)c2c1
Show InChI InChI=1S/C19H13F3N4O3S/c1-26-10-13(9-24-26)12-6-16-17(23-8-12)5-3-11-2-4-14(7-15(11)18(16)27)25-30(28,29)19(20,21)22/h2-10,25H,1H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-MET overexpressed in human GTL-16 cells assessed as phosphorylation at C-terminal Y1349 after 2 hrs by Western blot analysis


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347701
PNG
(CHEMBL1802598)
Show SMILES CS(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1ccoc1
Show InChI InChI=1S/C19H14N2O4S/c1-26(23,24)21-15-4-2-12-3-5-18-17(19(22)16(12)9-15)8-14(10-20-18)13-6-7-25-11-13/h2-11,21H,1H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-MET overexpressed in human GTL-16 cells assessed as phosphorylation at C-terminal Y1349 after 2 hrs by Western blot analysis


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347638
PNG
(CHEMBL1803014)
Show SMILES CS(=O)(=O)Nc1ccc2ccc3nc(N)c(cc3c(=O)c2c1)-c1ccccc1
Show InChI InChI=1S/C21H17N3O3S/c1-28(26,27)24-15-9-7-14-8-10-19-18(20(25)16(14)11-15)12-17(21(22)23-19)13-5-3-2-4-6-13/h2-12,24H,1H3,(H2,22,23)
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n/an/a 6.10E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluorescence reson...


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Cytochrome P450 3A


(Homo sapiens (Human))
BDBM50347659
PNG
(CHEMBL1802916 | MK-2461)
Show SMILES CN(C[C@@H]1COCCO1)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1 |r|
Show InChI InChI=1S/C24H25N5O5S/c1-28-13-18(12-26-28)17-9-22-23(25-11-17)6-4-16-3-5-19(10-21(16)24(22)30)27-35(31,32)29(2)14-20-15-33-7-8-34-20/h3-6,9-13,20,27H,7-8,14-15H2,1-2H3/t20-/m1/s1
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n/an/a 7.10E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of CYP3A4


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50347667
PNG
(CHEMBL1802909)
Show SMILES CN(Cc1cnccn1)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1
Show InChI InChI=1S/C24H21N7O3S/c1-30-14-18(12-28-30)17-9-22-23(27-11-17)6-4-16-3-5-19(10-21(16)24(22)32)29-35(33,34)31(2)15-20-13-25-7-8-26-20/h3-14,29H,15H2,1-2H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Kv11.1 channel


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347687
PNG
(CHEMBL1802828)
Show SMILES Cn1cc(cn1)-c1cnc2ccc3ccc(NS(=O)(=O)CCn4ccnc4)cc3c(=O)c2c1
Show InChI InChI=1S/C23H20N6O3S/c1-28-14-18(13-26-28)17-10-21-22(25-12-17)5-3-16-2-4-19(11-20(16)23(21)30)27-33(31,32)9-8-29-7-6-24-15-29/h2-7,10-15,27H,8-9H2,1H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-MET overexpressed in human GTL-16 cells assessed as phosphorylation at C-terminal Y1349 after 2 hrs by Western blot analysis


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))
BDBM50347659
PNG
(CHEMBL1802916 | MK-2461)
Show SMILES CN(C[C@@H]1COCCO1)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1 |r|
Show InChI InChI=1S/C24H25N5O5S/c1-28-13-18(12-26-28)17-9-22-23(25-11-17)6-4-16-3-5-19(10-21(16)24(22)30)27-35(31,32)29(2)14-20-15-33-7-8-34-20/h3-6,9-13,20,27H,7-8,14-15H2,1-2H3/t20-/m1/s1
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n/an/a 7.80E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human Abl


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347654
PNG
(CHEMBL1802587)
Show SMILES CCCCN(C)c1cnc2ccc3ccc(NS(C)(=O)=O)cc3c(=O)c2c1
Show InChI InChI=1S/C20H23N3O3S/c1-4-5-10-23(2)16-12-18-19(21-13-16)9-7-14-6-8-15(22-27(3,25)26)11-17(14)20(18)24/h6-9,11-13,22H,4-5,10H2,1-3H3
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n/an/a 8.00E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-MET overexpressed in human GTL-16 cells assessed as phosphorylation at C-terminal Y1349 after 2 hrs by Western blot analysis


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347691
PNG
(CHEMBL1802824)
Show SMILES O=c1c2cc(NS(=O)(=O)c3ccccc3)ccc2ccc2ncc(cc12)-c1ccccc1
Show InChI InChI=1S/C26H18N2O3S/c29-26-23-16-21(28-32(30,31)22-9-5-2-6-10-22)13-11-19(23)12-14-25-24(26)15-20(17-27-25)18-7-3-1-4-8-18/h1-17,28H
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n/an/a 9.00E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-MET overexpressed in human GTL-16 cells assessed as phosphorylation at C-terminal Y1349 after 2 hrs by Western blot analysis


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347649
PNG
(CHEMBL1802592)
Show SMILES CS(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1ccccc1Cl
Show InChI InChI=1S/C21H15ClN2O3S/c1-28(26,27)24-15-8-6-13-7-9-20-18(21(25)17(13)11-15)10-14(12-23-20)16-4-2-3-5-19(16)22/h2-12,24H,1H3
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n/an/a 9.00E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-MET overexpressed in human GTL-16 cells assessed as phosphorylation at C-terminal Y1349 after 2 hrs by Western blot analysis


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347702
PNG
(CHEMBL1802597)
Show SMILES CS(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cncnc1
Show InChI InChI=1S/C19H14N4O3S/c1-27(25,26)23-15-4-2-12-3-5-18-17(19(24)16(12)7-15)6-13(10-22-18)14-8-20-11-21-9-14/h2-11,23H,1H3
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n/an/a 9.00E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-MET overexpressed in human GTL-16 cells assessed as phosphorylation at C-terminal Y1349 after 2 hrs by Western blot analysis


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347692
PNG
(CHEMBL1802823)
Show SMILES C=CS(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1ccccc1
Show InChI InChI=1S/C22H16N2O3S/c1-2-28(26,27)24-18-10-8-16-9-11-21-20(22(25)19(16)13-18)12-17(14-23-21)15-6-4-3-5-7-15/h2-14,24H,1H2
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-MET overexpressed in human GTL-16 cells assessed as phosphorylation at C-terminal Y1349 after 2 hrs by Western blot analysis


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347640
PNG
(CHEMBL1803012)
Show SMILES CS(=O)(=O)Nc1ccc2ccc3nccc(Cl)c3c(=O)c2c1
Show InChI InChI=1S/C15H11ClN2O3S/c1-22(20,21)18-10-4-2-9-3-5-13-14(12(16)6-7-17-13)15(19)11(9)8-10/h2-8,18H,1H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluorescence reson...


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347684
PNG
(CHEMBL1803006)
Show SMILES CS(=O)(=O)Nc1ccc2C=Cc3ncc(cc3C(O)c2c1)-c1ccccc1 |c:9|
Show InChI InChI=1S/C21H18N2O3S/c1-27(25,26)23-17-9-7-15-8-10-20-19(21(24)18(15)12-17)11-16(13-22-20)14-5-3-2-4-6-14/h2-13,21,23-24H,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluorescence reson...


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347643
PNG
(CHEMBL1800105)
Show SMILES CS(=O)(=O)Nc1ccc2c(c1)ccc1ncc(cc1c2=O)-c1ccccc1
Show InChI InChI=1S/C21H16N2O3S/c1-27(25,26)23-17-8-9-18-15(11-17)7-10-20-19(21(18)24)12-16(13-22-20)14-5-3-2-4-6-14/h2-13,23H,1H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluorescence reson...


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50347686
PNG
(CHEMBL1802602)
Show SMILES Cn1cc(cn1)-c1cnc2ccc3ccc(NS(C)(=O)=O)cc3c(=O)c2c1
Show InChI InChI=1S/C19H16N4O3S/c1-23-11-14(10-21-23)13-7-17-18(20-9-13)6-4-12-3-5-15(22-27(2,25)26)8-16(12)19(17)24/h3-11,22H,1-2H3
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n/an/a 1.01E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Kv11.1 channel


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50347660
PNG
(CHEMBL1802915)
Show SMILES CN(C[C@H]1COCCO1)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1 |r|
Show InChI InChI=1S/C24H25N5O5S/c1-28-13-18(12-26-28)17-9-22-23(25-11-17)6-4-16-3-5-19(10-21(16)24(22)30)27-35(31,32)29(2)14-20-15-33-7-8-34-20/h3-6,9-13,20,27H,7-8,14-15H2,1-2H3/t20-/m0/s1
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n/an/a>3.00E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Kv11.1 channel


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50347659
PNG
(CHEMBL1802916 | MK-2461)
Show SMILES CN(C[C@@H]1COCCO1)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1 |r|
Show InChI InChI=1S/C24H25N5O5S/c1-28-13-18(12-26-28)17-9-22-23(25-11-17)6-4-16-3-5-19(10-21(16)24(22)30)27-35(31,32)29(2)14-20-15-33-7-8-34-20/h3-6,9-13,20,27H,7-8,14-15H2,1-2H3/t20-/m1/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Kv11.1 channel


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50347664
PNG
(CHEMBL1802911)
Show SMILES Cn1cc(cn1)-c1cnc2ccc3ccc(NS(=O)(=O)N4CCC4)cc3c(=O)c2c1
Show InChI InChI=1S/C21H19N5O3S/c1-25-13-16(12-23-25)15-9-19-20(22-11-15)6-4-14-3-5-17(10-18(14)21(19)27)24-30(28,29)26-7-2-8-26/h3-6,9-13,24H,2,7-8H2,1H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Kv11.1 channel


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50347663
PNG
(CHEMBL1802912)
Show SMILES Cn1cc(cn1)-c1cnc2ccc3ccc(NS(=O)(=O)N4CC(F)C4)cc3c(=O)c2c1
Show InChI InChI=1S/C21H18FN5O3S/c1-26-10-15(9-24-26)14-6-19-20(23-8-14)5-3-13-2-4-17(7-18(13)21(19)28)25-31(29,30)27-11-16(22)12-27/h2-10,16,25H,11-12H2,1H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Kv11.1 channel


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50347666
PNG
(CHEMBL1802910)
Show SMILES CN(Cc1ccccc1)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1
Show InChI InChI=1S/C26H23N5O3S/c1-30-17-21(15-28-30)20-12-24-25(27-14-20)11-9-19-8-10-22(13-23(19)26(24)32)29-35(33,34)31(2)16-18-6-4-3-5-7-18/h3-15,17,29H,16H2,1-2H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Kv11.1 channel


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50347669
PNG
(CHEMBL1802907)
Show SMILES CNS(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1
Show InChI InChI=1S/C19H17N5O3S/c1-20-28(26,27)23-15-5-3-12-4-6-18-17(19(25)16(12)8-15)7-13(9-21-18)14-10-22-24(2)11-14/h3-11,20,23H,1-2H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Kv11.1 channel


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50347661
PNG
(CHEMBL1802914)
Show SMILES CN([C@H]1CCOC1)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1 |r|
Show InChI InChI=1S/C23H23N5O4S/c1-27-13-17(12-25-27)16-9-21-22(24-11-16)6-4-15-3-5-18(10-20(15)23(21)29)26-33(30,31)28(2)19-7-8-32-14-19/h3-6,9-13,19,26H,7-8,14H2,1-2H3/t19-/m0/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Kv11.1 channel


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50347681
PNG
(CHEMBL1802829)
Show SMILES CN(C)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1
Show InChI InChI=1S/C20H19N5O3S/c1-24(2)29(27,28)23-16-6-4-13-5-7-19-18(20(26)17(13)9-16)8-14(10-21-19)15-11-22-25(3)12-15/h4-12,23H,1-3H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Kv11.1 channel


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50347668
PNG
(CHEMBL1802908)
Show SMILES CCN(CC)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1
Show InChI InChI=1S/C22H23N5O3S/c1-4-27(5-2)31(29,30)25-18-8-6-15-7-9-21-20(22(28)19(15)11-18)10-16(12-23-21)17-13-24-26(3)14-17/h6-14,25H,4-5H2,1-3H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Kv11.1 channel


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50347662
PNG
(CHEMBL1802913)
Show SMILES COCCCN(C)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1
Show InChI InChI=1S/C23H25N5O4S/c1-27-15-18(14-25-27)17-11-21-22(24-13-17)8-6-16-5-7-19(12-20(16)23(21)29)26-33(30,31)28(2)9-4-10-32-3/h5-8,11-15,26H,4,9-10H2,1-3H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Kv11.1 channel


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Cytochrome P450 2D6 (2D6)


(Homo sapiens (Human))
BDBM50347656
PNG
(CHEMBL1803004)
Show SMILES CS(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1ccccc1
Show InChI InChI=1S/C21H16N2O3S/c1-27(25,26)23-17-9-7-15-8-10-20-19(21(24)18(15)12-17)11-16(13-22-20)14-5-3-2-4-6-14/h2-13,23H,1H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of CYP2D6


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Cytochrome P450 3A


(Homo sapiens (Human))
BDBM50347656
PNG
(CHEMBL1803004)
Show SMILES CS(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1ccccc1
Show InChI InChI=1S/C21H16N2O3S/c1-27(25,26)23-17-9-7-15-8-10-20-19(21(24)18(15)12-17)11-16(13-22-20)14-5-3-2-4-6-14/h2-13,23H,1H3
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n/an/a>5.00E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of CYP3A4


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Cytochrome P450 2C9


(Homo sapiens (Human))
BDBM50347656
PNG
(CHEMBL1803004)
Show SMILES CS(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1ccccc1
Show InChI InChI=1S/C21H16N2O3S/c1-27(25,26)23-17-9-7-15-8-10-20-19(21(24)18(15)12-17)11-16(13-22-20)14-5-3-2-4-6-14/h2-13,23H,1H3
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n/an/a>5.00E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of CYP2C9


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Cytochrome P450 2D6 (2D6)


(Homo sapiens (Human))
BDBM50347659
PNG
(CHEMBL1802916 | MK-2461)
Show SMILES CN(C[C@@H]1COCCO1)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1 |r|
Show InChI InChI=1S/C24H25N5O5S/c1-28-13-18(12-26-28)17-9-22-23(25-11-17)6-4-16-3-5-19(10-21(16)24(22)30)27-35(31,32)29(2)14-20-15-33-7-8-34-20/h3-6,9-13,20,27H,7-8,14-15H2,1-2H3/t20-/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of CYP2D6


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347659
PNG
(CHEMBL1802916 | MK-2461)
Show SMILES CN(C[C@@H]1COCCO1)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1 |r|
Show InChI InChI=1S/C24H25N5O5S/c1-28-13-18(12-26-28)17-9-22-23(25-11-17)6-4-16-3-5-19(10-21(16)24(22)30)27-35(31,32)29(2)14-20-15-33-7-8-34-20/h3-6,9-13,20,27H,7-8,14-15H2,1-2H3/t20-/m1/s1
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n/an/an/a 4n/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to human recombinant His6-tagged phosphorylated c-Met cytosolic domain


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50347659
PNG
(CHEMBL1802916 | MK-2461)
Show SMILES CN(C[C@@H]1COCCO1)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1 |r|
Show InChI InChI=1S/C24H25N5O5S/c1-28-13-18(12-26-28)17-9-22-23(25-11-17)6-4-16-3-5-19(10-21(16)24(22)30)27-35(31,32)29(2)14-20-15-33-7-8-34-20/h3-6,9-13,20,27H,7-8,14-15H2,1-2H3/t20-/m1/s1
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n/an/an/a 25n/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to human recombinant His6-tagged unphosphorylated c-Met cytosolic domain


J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%