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PubMed code 2167979

Compile data set for download or QSAR
Found 43 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50012477
PNG
(1-Phenethyl-4-(phenyl-propionyl-amino)-piperidine-...)
Show SMILES CCC(=O)N(c1ccccc1)C1(CCN(CCc2ccccc2)CC1)C(=O)OC
Show InChI InChI=1S/C24H30N2O3/c1-3-22(27)26(21-12-8-5-9-13-21)24(23(28)29-2)15-18-25(19-16-24)17-14-20-10-6-4-7-11-20/h4-13H,3,14-19H2,1-2H3
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 0.0900n/an/an/an/an/an/an/an/a



Universit£ Louis Pasteur

Curated by ChEMBL


Assay Description
Inhibition of [3H]DAGO binding to rat brain membrane Opioid receptor mu 1

J Med Chem 33: 2456-64 (1990)


BindingDB Entry DOI: 10.7270/Q21Z451M
More data for this
Ligand-Target Pair
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1


(Rattus norvegicus (rat)-RAT)		BDBM50012477
PNG
(1-Phenethyl-4-(phenyl-propionyl-amino)-piperidine-...)
Show SMILES CCC(=O)N(c1ccccc1)C1(CCN(CCc2ccccc2)CC1)C(=O)OC
Show InChI InChI=1S/C24H30N2O3/c1-3-22(27)26(21-12-8-5-9-13-21)24(23(28)29-2)15-18-25(19-16-24)17-14-20-10-6-4-7-11-20/h4-13H,3,14-19H2,1-2H3
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 0.25n/an/an/an/an/an/an/an/a



Universit£ Louis Pasteur

Curated by ChEMBL


Assay Description
Inhibition of [3H]diprenorphine binding to rat brain membrane opioid receptors;(T= total opioid receptor family)

J Med Chem 33: 2456-64 (1990)


BindingDB Entry DOI: 10.7270/Q21Z451M
More data for this
Ligand-Target Pair
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1


(Rattus norvegicus (rat)-RAT)		BDBM50013849
PNG
(14-[4-azido(methyl)anilino]-4-cyclopropylmethyl-12...)
Show SMILES CN(C1CCC2(O)C3Cc4ccc(O)c5OC1C2(CCN3CC1CC1)c45)c1ccc(cc1)N=[N+]=[N-] |TLB:14:25:5:20.18.19,10:9:5:20.18.19,THB:4:5:25.9.8:20.18.19|
Show InChI InChI=1S/C27H31N5O3/c1-31(19-7-5-18(6-8-19)29-30-28)20-10-11-27(34)22-14-17-4-9-21(33)24-23(17)26(27,25(20)35-24)12-13-32(22)15-16-2-3-16/h4-9,16,20,22,25,33-34H,2-3,10-15H2,1H3
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 0.5n/an/an/an/an/an/an/an/a



Universit£ Louis Pasteur

Curated by ChEMBL


Assay Description
Inhibition of [3H]diprenorphine binding to rat brain membrane opioid receptors;(T= total opioid receptor family)

J Med Chem 33: 2456-64 (1990)


BindingDB Entry DOI: 10.7270/Q21Z451M
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50013847
PNG
(CHEMBL312040 | Etonitazene | {2-[2-(4-Ethoxy-benzy...)
Show SMILES CCOc1ccc(Cc2nc3cc(ccc3n2CCN(CC)CC)[N+]([O-])=O)cc1
Show InChI InChI=1S/C22H28N4O3/c1-4-24(5-2)13-14-25-21-12-9-18(26(27)28)16-20(21)23-22(25)15-17-7-10-19(11-8-17)29-6-3/h7-12,16H,4-6,13-15H2,1-3H3
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 0.5n/an/an/an/an/an/an/an/a



Universit£ Louis Pasteur

Curated by ChEMBL


Assay Description
Inhibition of [3H]DAGO binding to rat brain membrane Opioid receptor mu 1

J Med Chem 33: 2456-64 (1990)


BindingDB Entry DOI: 10.7270/Q21Z451M
More data for this
Ligand-Target Pair
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1


(Rattus norvegicus (rat)-RAT)		BDBM60212
PNG
((4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-bis(o...)
Show SMILES Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O
Show InChI InChI=1S/C20H23NO4/c22-13-4-3-12-9-15-20(24)6-5-14(23)18-19(20,16(12)17(13)25-18)7-8-21(15)10-11-1-2-11/h3-4,11,15,18,22,24H,1-2,5-10H2/t15-,18+,19+,20-/m1/s1
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 0.550n/an/an/an/an/an/an/an/a



Universit£ Louis Pasteur

Curated by ChEMBL


Assay Description
Inhibition of [3H]diprenorphine binding to rat brain membrane opioid receptors;(T= total opioid receptor family)

J Med Chem 33: 2456-64 (1990)


BindingDB Entry DOI: 10.7270/Q21Z451M
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50013857
PNG
(14-[4-diazo(methyl)anilino]-4-cyclopropylmethyl-12...)
Show SMILES CN(C1CCC2(O)C3Cc4ccc(O)c5OC1C2(CCN3CC1CC1)c45)c1ccc(cc1)[N+]#N |TLB:14:25:5:20.18.19,10:9:5:20.18.19,THB:4:5:25.9.8:20.18.19|
Show InChI InChI=1S/C27H30N4O3/c1-30(19-7-5-18(29-28)6-8-19)20-10-11-27(33)22-14-17-4-9-21(32)24-23(17)26(27,25(20)34-24)12-13-31(22)15-16-2-3-16/h4-9,16,20,22,25,33H,2-3,10-15H2,1H3/p+1
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 0.600n/an/an/an/an/an/an/an/a



Universit£ Louis Pasteur

Curated by ChEMBL


Assay Description
Inhibition of [3H]DAGO binding to rat brain membrane Opioid receptor mu 1

J Med Chem 33: 2456-64 (1990)


BindingDB Entry DOI: 10.7270/Q21Z451M
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50013849
PNG
(14-[4-azido(methyl)anilino]-4-cyclopropylmethyl-12...)
Show SMILES CN(C1CCC2(O)C3Cc4ccc(O)c5OC1C2(CCN3CC1CC1)c45)c1ccc(cc1)N=[N+]=[N-] |TLB:14:25:5:20.18.19,10:9:5:20.18.19,THB:4:5:25.9.8:20.18.19|
Show InChI InChI=1S/C27H31N5O3/c1-31(19-7-5-18(6-8-19)29-30-28)20-10-11-27(34)22-14-17-4-9-21(33)24-23(17)26(27,25(20)35-24)12-13-32(22)15-16-2-3-16/h4-9,16,20,22,25,33-34H,2-3,10-15H2,1H3
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 0.600n/an/an/an/an/an/an/an/a



Universit£ Louis Pasteur

Curated by ChEMBL


Assay Description
Inhibition of [3H]DAGO binding to rat brain membrane Opioid receptor mu 1

J Med Chem 33: 2456-64 (1990)


BindingDB Entry DOI: 10.7270/Q21Z451M
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50013857
PNG
(14-[4-diazo(methyl)anilino]-4-cyclopropylmethyl-12...)
Show SMILES CN(C1CCC2(O)C3Cc4ccc(O)c5OC1C2(CCN3CC1CC1)c45)c1ccc(cc1)[N+]#N |TLB:14:25:5:20.18.19,10:9:5:20.18.19,THB:4:5:25.9.8:20.18.19|
Show InChI InChI=1S/C27H30N4O3/c1-30(19-7-5-18(29-28)6-8-19)20-10-11-27(33)22-14-17-4-9-21(32)24-23(17)26(27,25(20)34-24)12-13-31(22)15-16-2-3-16/h4-9,16,20,22,25,33H,2-3,10-15H2,1H3/p+1
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 0.600n/an/an/an/an/an/an/an/a



Universit£ Louis Pasteur

Curated by ChEMBL


Assay Description
Opioid receptor delta 1 apparent binding constant from rat brain membranes using [3H]DADLE binding assay

J Med Chem 33: 2456-64 (1990)


BindingDB Entry DOI: 10.7270/Q21Z451M
More data for this
Ligand-Target Pair
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1


(Rattus norvegicus (rat)-RAT)		BDBM50013847
PNG
(CHEMBL312040 | Etonitazene | {2-[2-(4-Ethoxy-benzy...)
Show SMILES CCOc1ccc(Cc2nc3cc(ccc3n2CCN(CC)CC)[N+]([O-])=O)cc1
Show InChI InChI=1S/C22H28N4O3/c1-4-24(5-2)13-14-25-21-12-9-18(26(27)28)16-20(21)23-22(25)15-17-7-10-19(11-8-17)29-6-3/h7-12,16H,4-6,13-15H2,1-3H3
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 0.600n/an/an/an/an/an/an/an/a



Universit£ Louis Pasteur

Curated by ChEMBL


Assay Description
Inhibition of [3H]diprenorphine binding to rat brain membrane opioid receptors;(T= total opioid receptor family)

J Med Chem 33: 2456-64 (1990)


BindingDB Entry DOI: 10.7270/Q21Z451M
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50013849
PNG
(14-[4-azido(methyl)anilino]-4-cyclopropylmethyl-12...)
Show SMILES CN(C1CCC2(O)C3Cc4ccc(O)c5OC1C2(CCN3CC1CC1)c45)c1ccc(cc1)N=[N+]=[N-] |TLB:14:25:5:20.18.19,10:9:5:20.18.19,THB:4:5:25.9.8:20.18.19|
Show InChI InChI=1S/C27H31N5O3/c1-31(19-7-5-18(6-8-19)29-30-28)20-10-11-27(34)22-14-17-4-9-21(33)24-23(17)26(27,25(20)35-24)12-13-32(22)15-16-2-3-16/h4-9,16,20,22,25,33-34H,2-3,10-15H2,1H3
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 0.700n/an/an/an/an/an/an/an/a



Universit£ Louis Pasteur

Curated by ChEMBL


Assay Description
Opioid receptor delta 1 apparent binding constant from rat brain membranes using [3H]DADLE binding assay

J Med Chem 33: 2456-64 (1990)


BindingDB Entry DOI: 10.7270/Q21Z451M
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50013849
PNG
(14-[4-azido(methyl)anilino]-4-cyclopropylmethyl-12...)
Show SMILES CN(C1CCC2(O)C3Cc4ccc(O)c5OC1C2(CCN3CC1CC1)c45)c1ccc(cc1)N=[N+]=[N-] |TLB:14:25:5:20.18.19,10:9:5:20.18.19,THB:4:5:25.9.8:20.18.19|
Show InChI InChI=1S/C27H31N5O3/c1-31(19-7-5-18(6-8-19)29-30-28)20-10-11-27(34)22-14-17-4-9-21(33)24-23(17)26(27,25(20)35-24)12-13-32(22)15-16-2-3-16/h4-9,16,20,22,25,33-34H,2-3,10-15H2,1H3
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 0.700n/an/an/an/an/an/an/an/a



Universit£ Louis Pasteur

Curated by ChEMBL


Assay Description
Opioid receptor kappa 1 apparent binding constant from guinea pig cerebellum using [3H]diprenorphine binding assay

J Med Chem 33: 2456-64 (1990)


BindingDB Entry DOI: 10.7270/Q21Z451M
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50013857
PNG
(14-[4-diazo(methyl)anilino]-4-cyclopropylmethyl-12...)
Show SMILES CN(C1CCC2(O)C3Cc4ccc(O)c5OC1C2(CCN3CC1CC1)c45)c1ccc(cc1)[N+]#N |TLB:14:25:5:20.18.19,10:9:5:20.18.19,THB:4:5:25.9.8:20.18.19|
Show InChI InChI=1S/C27H30N4O3/c1-30(19-7-5-18(29-28)6-8-19)20-10-11-27(33)22-14-17-4-9-21(32)24-23(17)26(27,25(20)34-24)12-13-31(22)15-16-2-3-16/h4-9,16,20,22,25,33H,2-3,10-15H2,1H3/p+1
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 1n/an/an/an/an/an/an/an/a



Universit£ Louis Pasteur

Curated by ChEMBL


Assay Description
Opioid receptor kappa 1 apparent binding constant from guinea pig cerebellum using [3H]diprenorphine binding assay

J Med Chem 33: 2456-64 (1990)


BindingDB Entry DOI: 10.7270/Q21Z451M
More data for this
Ligand-Target Pair
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1


(Rattus norvegicus (rat)-RAT)		BDBM50013857
PNG
(14-[4-diazo(methyl)anilino]-4-cyclopropylmethyl-12...)
Show SMILES CN(C1CCC2(O)C3Cc4ccc(O)c5OC1C2(CCN3CC1CC1)c45)c1ccc(cc1)[N+]#N |TLB:14:25:5:20.18.19,10:9:5:20.18.19,THB:4:5:25.9.8:20.18.19|
Show InChI InChI=1S/C27H30N4O3/c1-30(19-7-5-18(29-28)6-8-19)20-10-11-27(33)22-14-17-4-9-21(32)24-23(17)26(27,25(20)34-24)12-13-31(22)15-16-2-3-16/h4-9,16,20,22,25,33H,2-3,10-15H2,1H3/p+1
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 1.70n/an/an/an/an/an/an/an/a



Universit£ Louis Pasteur

Curated by ChEMBL


Assay Description
Inhibition of [3H]diprenorphine binding to rat brain membrane opioid receptors;(T= total opioid receptor family)

J Med Chem 33: 2456-64 (1990)


BindingDB Entry DOI: 10.7270/Q21Z451M
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM60212
PNG
((4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-bis(o...)
Show SMILES Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O
Show InChI InChI=1S/C20H23NO4/c22-13-4-3-12-9-15-20(24)6-5-14(23)18-19(20,16(12)17(13)25-18)7-8-21(15)10-11-1-2-11/h3-4,11,15,18,22,24H,1-2,5-10H2/t15-,18+,19+,20-/m1/s1
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 1.80n/an/an/an/an/an/an/an/a



Universit£ Louis Pasteur

Curated by ChEMBL


Assay Description
Inhibition of [3H]DAGO binding to rat brain membrane Opioid receptor mu 1

J Med Chem 33: 2456-64 (1990)


BindingDB Entry DOI: 10.7270/Q21Z451M
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50013854
PNG
(CHEMBL310829 | {2-[5-Azido-2-(4-ethoxy-benzyl)-ben...)
Show SMILES CCOc1ccc(Cc2nc3cc(ccc3n2CCN(CC)CC)N=[N+]=[N-])cc1
Show InChI InChI=1S/C22H28N6O/c1-4-27(5-2)13-14-28-21-12-9-18(25-26-23)16-20(21)24-22(28)15-17-7-10-19(11-8-17)29-6-3/h7-12,16H,4-6,13-15H2,1-3H3
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 2n/an/an/an/an/an/an/an/a



Universit£ Louis Pasteur

Curated by ChEMBL


Assay Description
Inhibition of [3H]DAGO binding to rat brain membrane Opioid receptor mu 1

J Med Chem 33: 2456-64 (1990)


BindingDB Entry DOI: 10.7270/Q21Z451M
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50013855
PNG
(1-(4-Azido-phenyl)-8-[1-(4-chloro-phenyl)-ethyl]-1...)
Show SMILES CC(N1CCC2(CC1)N(CNC2=O)c1ccc(cc1)N=[N+]=[N-])c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23ClN6O/c1-15(16-2-4-17(22)5-3-16)27-12-10-21(11-13-27)20(29)24-14-28(21)19-8-6-18(7-9-19)25-26-23/h2-9,15H,10-14H2,1H3,(H,24,29)
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 3n/an/an/an/an/an/an/an/a



Universit£ Louis Pasteur

Curated by ChEMBL


Assay Description
Inhibition of [3H]DAGO binding to rat brain membrane Opioid receptor mu 1

J Med Chem 33: 2456-64 (1990)


BindingDB Entry DOI: 10.7270/Q21Z451M
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50013848
PNG
(8-[1-(4-Chloro-phenyl)-ethyl]-1-phenyl-1,3,8-triaz...)
Show SMILES CC(N1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H24ClN3O/c1-16(17-7-9-18(22)10-8-17)24-13-11-21(12-14-24)20(26)23-15-25(21)19-5-3-2-4-6-19/h2-10,16H,11-15H2,1H3,(H,23,26)
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 4n/an/an/an/an/an/an/an/a



Universit£ Louis Pasteur

Curated by ChEMBL


Assay Description
Inhibition of [3H]DAGO binding to rat brain membrane Opioid receptor mu 1

J Med Chem 33: 2456-64 (1990)


BindingDB Entry DOI: 10.7270/Q21Z451M
More data for this
Ligand-Target Pair
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1


(Rattus norvegicus (rat)-RAT)		BDBM50013854
PNG
(CHEMBL310829 | {2-[5-Azido-2-(4-ethoxy-benzyl)-ben...)
Show SMILES CCOc1ccc(Cc2nc3cc(ccc3n2CCN(CC)CC)N=[N+]=[N-])cc1
Show InChI InChI=1S/C22H28N6O/c1-4-27(5-2)13-14-28-21-12-9-18(25-26-23)16-20(21)24-22(28)15-17-7-10-19(11-8-17)29-6-3/h7-12,16H,4-6,13-15H2,1-3H3
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 4n/an/an/an/an/an/an/an/a



Universit£ Louis Pasteur

Curated by ChEMBL


Assay Description
Inhibition of [3H]diprenorphine binding to rat brain membrane opioid receptors;(T= total opioid receptor family)

J Med Chem 33: 2456-64 (1990)


BindingDB Entry DOI: 10.7270/Q21Z451M
More data for this
Ligand-Target Pair
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1


(Rattus norvegicus (rat)-RAT)		BDBM50013855
PNG
(1-(4-Azido-phenyl)-8-[1-(4-chloro-phenyl)-ethyl]-1...)
Show SMILES CC(N1CCC2(CC1)N(CNC2=O)c1ccc(cc1)N=[N+]=[N-])c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23ClN6O/c1-15(16-2-4-17(22)5-3-16)27-12-10-21(11-13-27)20(29)24-14-28(21)19-8-6-18(7-9-19)25-26-23/h2-9,15H,10-14H2,1H3,(H,24,29)
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 5n/an/an/an/an/an/an/an/a



Universit£ Louis Pasteur

Curated by ChEMBL


Assay Description
Inhibition of [3H]diprenorphine binding to rat brain membrane opioid receptors;(T= total opioid receptor family)

J Med Chem 33: 2456-64 (1990)


BindingDB Entry DOI: 10.7270/Q21Z451M
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM60212
PNG
((4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-bis(o...)
Show SMILES Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O
Show InChI InChI=1S/C20H23NO4/c22-13-4-3-12-9-15-20(24)6-5-14(23)18-19(20,16(12)17(13)25-18)7-8-21(15)10-11-1-2-11/h3-4,11,15,18,22,24H,1-2,5-10H2/t15-,18+,19+,20-/m1/s1
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 6.70n/an/an/an/an/an/an/an/a



Universit£ Louis Pasteur

Curated by ChEMBL


Assay Description
Opioid receptor delta 1 apparent binding constant from rat brain membranes using [3H]DADLE binding assay

J Med Chem 33: 2456-64 (1990)


BindingDB Entry DOI: 10.7270/Q21Z451M
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50013853
PNG
(1-[2-(4-Azido-phenyl)-ethyl]-4-(phenyl-propionyl-a...)
Show SMILES CCC(=O)N(c1ccccc1)C1(CCN(CCc2ccc(cc2)N=[N+]=[N-])CC1)C(=O)OC
Show InChI InChI=1S/C24H29N5O3/c1-3-22(30)29(21-7-5-4-6-8-21)24(23(31)32-2)14-17-28(18-15-24)16-13-19-9-11-20(12-10-19)26-27-25/h4-12H,3,13-18H2,1-2H3
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 8n/an/an/an/an/an/an/an/a



Universit£ Louis Pasteur

Curated by ChEMBL


Assay Description
Inhibition of [3H]DAGO binding to rat brain membrane Opioid receptor mu 1

J Med Chem 33: 2456-64 (1990)


BindingDB Entry DOI: 10.7270/Q21Z451M
More data for this
Ligand-Target Pair
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1


(Rattus norvegicus (rat)-RAT)		BDBM50013853
PNG
(1-[2-(4-Azido-phenyl)-ethyl]-4-(phenyl-propionyl-a...)
Show SMILES CCC(=O)N(c1ccccc1)C1(CCN(CCc2ccc(cc2)N=[N+]=[N-])CC1)C(=O)OC
Show InChI InChI=1S/C24H29N5O3/c1-3-22(30)29(21-7-5-4-6-8-21)24(23(31)32-2)14-17-28(18-15-24)16-13-19-9-11-20(12-10-19)26-27-25/h4-12H,3,13-18H2,1-2H3
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 8n/an/an/an/an/an/an/an/a



Universit£ Louis Pasteur

Curated by ChEMBL


Assay Description
Inhibition of [3H]diprenorphine binding to rat brain membrane opioid receptors;(T= total opioid receptor family)

J Med Chem 33: 2456-64 (1990)


BindingDB Entry DOI: 10.7270/Q21Z451M
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM60212
PNG
((4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-bis(o...)
Show SMILES Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O
Show InChI InChI=1S/C20H23NO4/c22-13-4-3-12-9-15-20(24)6-5-14(23)18-19(20,16(12)17(13)25-18)7-8-21(15)10-11-1-2-11/h3-4,11,15,18,22,24H,1-2,5-10H2/t15-,18+,19+,20-/m1/s1
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 8.70n/an/an/an/an/an/an/an/a



Universit£ Louis Pasteur

Curated by ChEMBL


Assay Description
Opioid receptor kappa 1 apparent binding constant from guinea pig cerebellum using [3H]diprenorphine binding assay

J Med Chem 33: 2456-64 (1990)


BindingDB Entry DOI: 10.7270/Q21Z451M
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50012477
PNG
(1-Phenethyl-4-(phenyl-propionyl-amino)-piperidine-...)
Show SMILES CCC(=O)N(c1ccccc1)C1(CCN(CCc2ccccc2)CC1)C(=O)OC
Show InChI InChI=1S/C24H30N2O3/c1-3-22(27)26(21-12-8-5-9-13-21)24(23(28)29-2)15-18-25(19-16-24)17-14-20-10-6-4-7-11-20/h4-13H,3,14-19H2,1-2H3
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 9n/an/an/an/an/an/an/an/a



Universit£ Louis Pasteur

Curated by ChEMBL


Assay Description
Opioid receptor kappa 1 apparent binding constant from rat brain membranes using [3H]DADLE binding assay

J Med Chem 33: 2456-64 (1990)


BindingDB Entry DOI: 10.7270/Q21Z451M
More data for this
Ligand-Target Pair
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1


(Rattus norvegicus (rat)-RAT)		BDBM50013848
PNG
(8-[1-(4-Chloro-phenyl)-ethyl]-1-phenyl-1,3,8-triaz...)
Show SMILES CC(N1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H24ClN3O/c1-16(17-7-9-18(22)10-8-17)24-13-11-21(12-14-24)20(26)23-15-25(21)19-5-3-2-4-6-19/h2-10,16H,11-15H2,1H3,(H,23,26)
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 10n/an/an/an/an/an/an/an/a



Universit£ Louis Pasteur

Curated by ChEMBL


Assay Description
Inhibition of [3H]diprenorphine binding to rat brain membrane opioid receptors;(T= total opioid receptor family)

J Med Chem 33: 2456-64 (1990)


BindingDB Entry DOI: 10.7270/Q21Z451M
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50013852
PNG
(1-(2-Diethylamino-ethyl)-2-(4-ethoxy-benzyl)-1H-be...)
Show SMILES CCOc1ccc(Cc2nc3cc(ccc3n2CCN(CC)CC)[N+]#N)cc1
Show InChI InChI=1S/C22H28N5O/c1-4-26(5-2)13-14-27-21-12-9-18(25-23)16-20(21)24-22(27)15-17-7-10-19(11-8-17)28-6-3/h7-12,16H,4-6,13-15H2,1-3H3/q+1
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 11n/an/an/an/an/an/an/an/a



Universit£ Louis Pasteur

Curated by ChEMBL


Assay Description
Inhibition of [3H]DAGO binding to rat brain membrane Opioid receptor mu 1

J Med Chem 33: 2456-64 (1990)


BindingDB Entry DOI: 10.7270/Q21Z451M
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50013850
PNG
(4-{8-[1-(4-Chloro-phenyl)-ethyl]-4-oxo-1,3,8-triaz...)
Show SMILES CC(N1CCC2(CC1)N(CNC2=O)c1ccc(cc1)[N+]#N)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H22ClN5O/c1-15(16-2-4-17(22)5-3-16)26-12-10-21(11-13-26)20(28)24-14-27(21)19-8-6-18(25-23)7-9-19/h2-9,15H,10-14H2,1H3/p+1
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 11n/an/an/an/an/an/an/an/a



Universit£ Louis Pasteur

Curated by ChEMBL


Assay Description
Inhibition of [3H]DAGO binding to rat brain membrane Opioid receptor mu 1

J Med Chem 33: 2456-64 (1990)


BindingDB Entry DOI: 10.7270/Q21Z451M
More data for this
Ligand-Target Pair
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1


(Rattus norvegicus (rat)-RAT)		BDBM50013852
PNG
(1-(2-Diethylamino-ethyl)-2-(4-ethoxy-benzyl)-1H-be...)
Show SMILES CCOc1ccc(Cc2nc3cc(ccc3n2CCN(CC)CC)[N+]#N)cc1
Show InChI InChI=1S/C22H28N5O/c1-4-26(5-2)13-14-27-21-12-9-18(25-23)16-20(21)24-22(27)15-17-7-10-19(11-8-17)28-6-3/h7-12,16H,4-6,13-15H2,1-3H3/q+1
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 18n/an/an/an/an/an/an/an/a



Universit£ Louis Pasteur

Curated by ChEMBL


Assay Description
Inhibition of [3H]diprenorphine binding to rat brain membrane opioid receptors;(T= total opioid receptor family)

J Med Chem 33: 2456-64 (1990)


BindingDB Entry DOI: 10.7270/Q21Z451M
More data for this
Ligand-Target Pair
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1


(Rattus norvegicus (rat)-RAT)		BDBM50013856
PNG
(1-[2-(4-Azido-3-iodo-phenyl)-ethyl]-4-(phenyl-prop...)
Show SMILES CCC(=O)N(c1ccccc1)C1(CCN(CCc2ccc(N=[N+]=[N-])c(I)c2)CC1)C(=O)OC
Show InChI InChI=1S/C24H28IN5O3/c1-3-22(31)30(19-7-5-4-6-8-19)24(23(32)33-2)12-15-29(16-13-24)14-11-18-9-10-21(27-28-26)20(25)17-18/h4-10,17H,3,11-16H2,1-2H3
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 27n/an/an/an/an/an/an/an/a



Universit£ Louis Pasteur

Curated by ChEMBL


Assay Description
Inhibition of [3H]diprenorphine binding to rat brain membrane opioid receptors;(T= total opioid receptor family)

J Med Chem 33: 2456-64 (1990)


BindingDB Entry DOI: 10.7270/Q21Z451M
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50013856
PNG
(1-[2-(4-Azido-3-iodo-phenyl)-ethyl]-4-(phenyl-prop...)
Show SMILES CCC(=O)N(c1ccccc1)C1(CCN(CCc2ccc(N=[N+]=[N-])c(I)c2)CC1)C(=O)OC
Show InChI InChI=1S/C24H28IN5O3/c1-3-22(31)30(19-7-5-4-6-8-19)24(23(32)33-2)12-15-29(16-13-24)14-11-18-9-10-21(27-28-26)20(25)17-18/h4-10,17H,3,11-16H2,1-2H3
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 45n/an/an/an/an/an/an/an/a



Universit£ Louis Pasteur

Curated by ChEMBL


Assay Description
Inhibition of [3H]DAGO binding to rat brain membrane Opioid receptor mu 1

J Med Chem 33: 2456-64 (1990)


BindingDB Entry DOI: 10.7270/Q21Z451M
More data for this
Ligand-Target Pair
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1


(Rattus norvegicus (rat)-RAT)		BDBM50013850
PNG
(4-{8-[1-(4-Chloro-phenyl)-ethyl]-4-oxo-1,3,8-triaz...)
Show SMILES CC(N1CCC2(CC1)N(CNC2=O)c1ccc(cc1)[N+]#N)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H22ClN5O/c1-15(16-2-4-17(22)5-3-16)26-12-10-21(11-13-26)20(28)24-14-27(21)19-8-6-18(25-23)7-9-19/h2-9,15H,10-14H2,1H3/p+1
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 62n/an/an/an/an/an/an/an/a



Universit£ Louis Pasteur

Curated by ChEMBL


Assay Description
Inhibition of [3H]diprenorphine binding to rat brain membrane opioid receptors;(T= total opioid receptor family)

J Med Chem 33: 2456-64 (1990)


BindingDB Entry DOI: 10.7270/Q21Z451M
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50013848
PNG
(8-[1-(4-Chloro-phenyl)-ethyl]-1-phenyl-1,3,8-triaz...)
Show SMILES CC(N1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H24ClN3O/c1-16(17-7-9-18(22)10-8-17)24-13-11-21(12-14-24)20(26)23-15-25(21)19-5-3-2-4-6-19/h2-10,16H,11-15H2,1H3,(H,23,26)
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 75n/an/an/an/an/an/an/an/a



Universit£ Louis Pasteur

Curated by ChEMBL


Assay Description
Opioid receptor delta 1 apparent binding constant from rat brain membranes using [3H]DADLE binding assay

J Med Chem 33: 2456-64 (1990)


BindingDB Entry DOI: 10.7270/Q21Z451M
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50012477
PNG
(1-Phenethyl-4-(phenyl-propionyl-amino)-piperidine-...)
Show SMILES CCC(=O)N(c1ccccc1)C1(CCN(CCc2ccccc2)CC1)C(=O)OC
Show InChI InChI=1S/C24H30N2O3/c1-3-22(27)26(21-12-8-5-9-13-21)24(23(28)29-2)15-18-25(19-16-24)17-14-20-10-6-4-7-11-20/h4-13H,3,14-19H2,1-2H3
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 92n/an/an/an/an/an/an/an/a



Universit£ Louis Pasteur

Curated by ChEMBL


Assay Description
Opioid receptor kappa 1 apparent binding constant from guinea pig cerebellum using [3H]diprenorphine binding assay

J Med Chem 33: 2456-64 (1990)


BindingDB Entry DOI: 10.7270/Q21Z451M
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50013855
PNG
(1-(4-Azido-phenyl)-8-[1-(4-chloro-phenyl)-ethyl]-1...)
Show SMILES CC(N1CCC2(CC1)N(CNC2=O)c1ccc(cc1)N=[N+]=[N-])c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23ClN6O/c1-15(16-2-4-17(22)5-3-16)27-12-10-21(11-13-27)20(29)24-14-28(21)19-8-6-18(7-9-19)25-26-23/h2-9,15H,10-14H2,1H3,(H,24,29)
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 100n/an/an/an/an/an/an/an/a



Universit£ Louis Pasteur

Curated by ChEMBL


Assay Description
Opioid receptor delta 1 apparent binding constant from rat brain membranes using [3H]DADLE binding assay

J Med Chem 33: 2456-64 (1990)


BindingDB Entry DOI: 10.7270/Q21Z451M
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50013854
PNG
(CHEMBL310829 | {2-[5-Azido-2-(4-ethoxy-benzyl)-ben...)
Show SMILES CCOc1ccc(Cc2nc3cc(ccc3n2CCN(CC)CC)N=[N+]=[N-])cc1
Show InChI InChI=1S/C22H28N6O/c1-4-27(5-2)13-14-28-21-12-9-18(25-26-23)16-20(21)24-22(28)15-17-7-10-19(11-8-17)29-6-3/h7-12,16H,4-6,13-15H2,1-3H3
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 242n/an/an/an/an/an/an/an/a



Universit£ Louis Pasteur

Curated by ChEMBL


Assay Description
Opioid receptor kappa 1 apparent binding constant from guinea pig cerebellum using [3H]diprenorphine binding assay

J Med Chem 33: 2456-64 (1990)


BindingDB Entry DOI: 10.7270/Q21Z451M
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50013854
PNG
(CHEMBL310829 | {2-[5-Azido-2-(4-ethoxy-benzyl)-ben...)
Show SMILES CCOc1ccc(Cc2nc3cc(ccc3n2CCN(CC)CC)N=[N+]=[N-])cc1
Show InChI InChI=1S/C22H28N6O/c1-4-27(5-2)13-14-28-21-12-9-18(25-26-23)16-20(21)24-22(28)15-17-7-10-19(11-8-17)29-6-3/h7-12,16H,4-6,13-15H2,1-3H3
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 400n/an/an/an/an/an/an/an/a



Universit£ Louis Pasteur

Curated by ChEMBL


Assay Description
Opioid receptor delta 1 apparent binding constant from rat brain membranes using [3H]DADLE binding assay

J Med Chem 33: 2456-64 (1990)


BindingDB Entry DOI: 10.7270/Q21Z451M
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50013853
PNG
(1-[2-(4-Azido-phenyl)-ethyl]-4-(phenyl-propionyl-a...)
Show SMILES CCC(=O)N(c1ccccc1)C1(CCN(CCc2ccc(cc2)N=[N+]=[N-])CC1)C(=O)OC
Show InChI InChI=1S/C24H29N5O3/c1-3-22(30)29(21-7-5-4-6-8-21)24(23(31)32-2)14-17-28(18-15-24)16-13-19-9-11-20(12-10-19)26-27-25/h4-12H,3,13-18H2,1-2H3
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>1.00E+3n/an/an/an/an/an/an/an/a



Universit£ Louis Pasteur

Curated by ChEMBL


Assay Description
Opioid receptor delta 1 apparent binding constant from rat brain membranes using [3H]DADLE binding assay

J Med Chem 33: 2456-64 (1990)


BindingDB Entry DOI: 10.7270/Q21Z451M
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50013850
PNG
(4-{8-[1-(4-Chloro-phenyl)-ethyl]-4-oxo-1,3,8-triaz...)
Show SMILES CC(N1CCC2(CC1)N(CNC2=O)c1ccc(cc1)[N+]#N)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H22ClN5O/c1-15(16-2-4-17(22)5-3-16)26-12-10-21(11-13-26)20(28)24-14-27(21)19-8-6-18(25-23)7-9-19/h2-9,15H,10-14H2,1H3/p+1
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>1.00E+3n/an/an/an/an/an/an/an/a



Universit£ Louis Pasteur

Curated by ChEMBL


Assay Description
Opioid receptor delta 1 apparent binding constant from rat brain membranes using [3H]DADLE binding assay

J Med Chem 33: 2456-64 (1990)


BindingDB Entry DOI: 10.7270/Q21Z451M
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50013856
PNG
(1-[2-(4-Azido-3-iodo-phenyl)-ethyl]-4-(phenyl-prop...)
Show SMILES CCC(=O)N(c1ccccc1)C1(CCN(CCc2ccc(N=[N+]=[N-])c(I)c2)CC1)C(=O)OC
Show InChI InChI=1S/C24H28IN5O3/c1-3-22(31)30(19-7-5-4-6-8-19)24(23(32)33-2)12-15-29(16-13-24)14-11-18-9-10-21(27-28-26)20(25)17-18/h4-10,17H,3,11-16H2,1-2H3
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>1.00E+3n/an/an/an/an/an/an/an/a



Universit£ Louis Pasteur

Curated by ChEMBL


Assay Description
Opioid receptor delta 1 apparent binding constant from rat brain membranes using [3H]DADLE binding assay

J Med Chem 33: 2456-64 (1990)


BindingDB Entry DOI: 10.7270/Q21Z451M
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50013847
PNG
(CHEMBL312040 | Etonitazene | {2-[2-(4-Ethoxy-benzy...)
Show SMILES CCOc1ccc(Cc2nc3cc(ccc3n2CCN(CC)CC)[N+]([O-])=O)cc1
Show InChI InChI=1S/C22H28N4O3/c1-4-24(5-2)13-14-25-21-12-9-18(26(27)28)16-20(21)23-22(25)15-17-7-10-19(11-8-17)29-6-3/h7-12,16H,4-6,13-15H2,1-3H3
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>1.00E+3n/an/an/an/an/an/an/an/a



Universit£ Louis Pasteur

Curated by ChEMBL


Assay Description
Opioid receptor delta 1 apparent binding constant from rat brain membranes using [3H]DADLE binding assay

J Med Chem 33: 2456-64 (1990)


BindingDB Entry DOI: 10.7270/Q21Z451M
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50013853
PNG
(1-[2-(4-Azido-phenyl)-ethyl]-4-(phenyl-propionyl-a...)
Show SMILES CCC(=O)N(c1ccccc1)C1(CCN(CCc2ccc(cc2)N=[N+]=[N-])CC1)C(=O)OC
Show InChI InChI=1S/C24H29N5O3/c1-3-22(30)29(21-7-5-4-6-8-21)24(23(31)32-2)14-17-28(18-15-24)16-13-19-9-11-20(12-10-19)26-27-25/h4-12H,3,13-18H2,1-2H3
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Universit£ Louis Pasteur

Curated by ChEMBL


Assay Description
Opioid receptor kappa 1 apparent binding constant from guinea pig cerebellum using [3H]diprenorphine binding assay

J Med Chem 33: 2456-64 (1990)


BindingDB Entry DOI: 10.7270/Q21Z451M
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50013856
PNG
(1-[2-(4-Azido-3-iodo-phenyl)-ethyl]-4-(phenyl-prop...)
Show SMILES CCC(=O)N(c1ccccc1)C1(CCN(CCc2ccc(N=[N+]=[N-])c(I)c2)CC1)C(=O)OC
Show InChI InChI=1S/C24H28IN5O3/c1-3-22(31)30(19-7-5-4-6-8-19)24(23(32)33-2)12-15-29(16-13-24)14-11-18-9-10-21(27-28-26)20(25)17-18/h4-10,17H,3,11-16H2,1-2H3
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Universit£ Louis Pasteur

Curated by ChEMBL


Assay Description
Opioid receptor kappa 1 apparent binding constant from guinea pig cerebellum using [3H]diprenorphine binding assay

J Med Chem 33: 2456-64 (1990)


BindingDB Entry DOI: 10.7270/Q21Z451M
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50013852
PNG
(1-(2-Diethylamino-ethyl)-2-(4-ethoxy-benzyl)-1H-be...)
Show SMILES CCOc1ccc(Cc2nc3cc(ccc3n2CCN(CC)CC)[N+]#N)cc1
Show InChI InChI=1S/C22H28N5O/c1-4-26(5-2)13-14-27-21-12-9-18(25-23)16-20(21)24-22(27)15-17-7-10-19(11-8-17)28-6-3/h7-12,16H,4-6,13-15H2,1-3H3/q+1
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>1.00E+4n/an/an/an/an/an/an/an/a



Universit£ Louis Pasteur

Curated by ChEMBL


Assay Description
Opioid receptor delta 1 apparent binding constant from rat brain membranes using [3H]DADLE binding assay

J Med Chem 33: 2456-64 (1990)


BindingDB Entry DOI: 10.7270/Q21Z451M
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%