Affinity Data by PubMed id=21705115

PubMed code 21705115

Found 37 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat))	BDBM31592 (PF-2545920 \| US9138494, MP-10 \| substituted pyraz...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase DrugBank MCE MMDB PC cid PC sid PDB UniChem Similars	MMDB PDB Article PubMed	n/a	n/a	0.180	n/a	n/a	n/a	n/a	n/a	n/a
Washington University Curated by ChEMBL					Assay Description Inhibition of rat PDE10A				Eur J Med Chem 46: 3986-95 (2011) Article DOI: 10.1016/j.ejmech.2011.05.072 BindingDB Entry DOI: 10.7270/Q279452C
Washington University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat))	BDBM31596 (substituted pyrazole, 13) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Washington University Curated by ChEMBL					Assay Description Inhibition of rat PDE10A				Eur J Med Chem 46: 3986-95 (2011) Article DOI: 10.1016/j.ejmech.2011.05.072 BindingDB Entry DOI: 10.7270/Q279452C
Washington University Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat))	BDBM50351893 (CHEMBL1825071) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Washington University Curated by ChEMBL					Assay Description Inhibition of rat PDE10A				Eur J Med Chem 46: 3986-95 (2011) Article DOI: 10.1016/j.ejmech.2011.05.072 BindingDB Entry DOI: 10.7270/Q279452C
Washington University Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM14754 (1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-isoq...) Show SMILES COc1ccc(Cc2nccc3cc(OC)c(OC)cc23)cc1OC Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Washington University Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE10A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assay				Eur J Med Chem 46: 3986-95 (2011) Article DOI: 10.1016/j.ejmech.2011.05.072 BindingDB Entry DOI: 10.7270/Q279452C
Washington University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50351891 (CHEMBL1821790) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
Washington University Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE10A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assay				Eur J Med Chem 46: 3986-95 (2011) Article DOI: 10.1016/j.ejmech.2011.05.072 BindingDB Entry DOI: 10.7270/Q279452C
Washington University Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat))	BDBM14754 (1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-isoq...) Show SMILES COc1ccc(Cc2nccc3cc(OC)c(OC)cc23)cc1OC Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
Washington University Curated by ChEMBL					Assay Description Inhibition of rat PDE10A				Eur J Med Chem 46: 3986-95 (2011) Article DOI: 10.1016/j.ejmech.2011.05.072 BindingDB Entry DOI: 10.7270/Q279452C
Washington University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50351892 (CHEMBL1821791) Show SMILES COc1ccc(Cc2nccc3cc(OC)c(OC)cc23)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	48.8	n/a	n/a	n/a	n/a	n/a	n/a
Washington University Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE10A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assay				Eur J Med Chem 46: 3986-95 (2011) Article DOI: 10.1016/j.ejmech.2011.05.072 BindingDB Entry DOI: 10.7270/Q279452C
Washington University Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50351908 (CHEMBL1821774) Show SMILES COc1ccc(Cc2nccc3cc(OCCF)c(OC)cc23)cc1F Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	49	n/a	n/a	n/a	n/a	n/a	n/a
Washington University Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE10A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assay				Eur J Med Chem 46: 3986-95 (2011) Article DOI: 10.1016/j.ejmech.2011.05.072 BindingDB Entry DOI: 10.7270/Q279452C
Washington University Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50351890 (CHEMBL1821787) Show SMILES COc1ccc(Cc2nccc3cc(OC)c(OC)cc23)cc1OCCF Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Washington University Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE10A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assay				Eur J Med Chem 46: 3986-95 (2011) Article DOI: 10.1016/j.ejmech.2011.05.072 BindingDB Entry DOI: 10.7270/Q279452C
Washington University Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50351894 (CHEMBL1821789) Show SMILES COc1cc(Cc2nccc3cc(OC)c(OC)cc23)ccc1OCCF Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Washington University Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE10A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assay				Eur J Med Chem 46: 3986-95 (2011) Article DOI: 10.1016/j.ejmech.2011.05.072 BindingDB Entry DOI: 10.7270/Q279452C
Washington University Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50351895 (CHEMBL1821775) Show SMILES COc1ccc(Cc2nccc3cc(OCCF)c(OC)cc23)cc1C Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	58.5	n/a	n/a	n/a	n/a	n/a	n/a
Washington University Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE10A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assay				Eur J Med Chem 46: 3986-95 (2011) Article DOI: 10.1016/j.ejmech.2011.05.072 BindingDB Entry DOI: 10.7270/Q279452C
Washington University Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50351896 (CHEMBL1821776) Show SMILES COc1cc2c(Cc3ccc(SC)cc3)nccc2cc1OCCF Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	112	n/a	n/a	n/a	n/a	n/a	n/a
Washington University Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE10A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assay				Eur J Med Chem 46: 3986-95 (2011) Article DOI: 10.1016/j.ejmech.2011.05.072 BindingDB Entry DOI: 10.7270/Q279452C
Washington University Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50351897 (CHEMBL1821777) Show SMILES COc1ccc(Cc2nccc3cc(OC)c(OCCF)cc23)cc1F Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	198	n/a	n/a	n/a	n/a	n/a	n/a
Washington University Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE10A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assay				Eur J Med Chem 46: 3986-95 (2011) Article DOI: 10.1016/j.ejmech.2011.05.072 BindingDB Entry DOI: 10.7270/Q279452C
Washington University Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50351898 (CHEMBL1821784) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Washington University Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE10A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assay				Eur J Med Chem 46: 3986-95 (2011) Article DOI: 10.1016/j.ejmech.2011.05.072 BindingDB Entry DOI: 10.7270/Q279452C
Washington University Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50351899 (CHEMBL1821779) Show SMILES COc1cc2ccnc(Cc3ccc(SC)cc3)c2cc1OCCF Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	237	n/a	n/a	n/a	n/a	n/a	n/a
Washington University Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE10A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assay				Eur J Med Chem 46: 3986-95 (2011) Article DOI: 10.1016/j.ejmech.2011.05.072 BindingDB Entry DOI: 10.7270/Q279452C
Washington University Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50351900 (CHEMBL1821778) Show SMILES COc1ccc(Cc2nccc3cc(OC)c(OCCF)cc23)cc1C Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	244	n/a	n/a	n/a	n/a	n/a	n/a
Washington University Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE10A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assay				Eur J Med Chem 46: 3986-95 (2011) Article DOI: 10.1016/j.ejmech.2011.05.072 BindingDB Entry DOI: 10.7270/Q279452C
Washington University Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50351901 (CHEMBL1821788) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	246	n/a	n/a	n/a	n/a	n/a	n/a
Washington University Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE10A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assay				Eur J Med Chem 46: 3986-95 (2011) Article DOI: 10.1016/j.ejmech.2011.05.072 BindingDB Entry DOI: 10.7270/Q279452C
Washington University Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50351902 (CHEMBL1821782) Show SMILES COc1ccc(Cc2nccc3cc(OC)c(OCCF)cc23)cc1Br Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	248	n/a	n/a	n/a	n/a	n/a	n/a
Washington University Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE10A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assay				Eur J Med Chem 46: 3986-95 (2011) Article DOI: 10.1016/j.ejmech.2011.05.072 BindingDB Entry DOI: 10.7270/Q279452C
Washington University Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50351903 (CHEMBL1821785) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	262	n/a	n/a	n/a	n/a	n/a	n/a
Washington University Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE10A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assay				Eur J Med Chem 46: 3986-95 (2011) Article DOI: 10.1016/j.ejmech.2011.05.072 BindingDB Entry DOI: 10.7270/Q279452C
Washington University Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50351904 (CHEMBL1821786) Show SMILES COc1cc(Cc2nccc3cc(OC)c(OCCF)cc23)ccc1F Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	303	n/a	n/a	n/a	n/a	n/a	n/a
Washington University Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE10A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assay				Eur J Med Chem 46: 3986-95 (2011) Article DOI: 10.1016/j.ejmech.2011.05.072 BindingDB Entry DOI: 10.7270/Q279452C
Washington University Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50351905 (CHEMBL1821783) Show SMILES COc1cc2ccnc(Cc3cccc(F)c3)c2cc1OCCF Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	469	n/a	n/a	n/a	n/a	n/a	n/a
Washington University Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE10A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assay				Eur J Med Chem 46: 3986-95 (2011) Article DOI: 10.1016/j.ejmech.2011.05.072 BindingDB Entry DOI: 10.7270/Q279452C
Washington University Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50351906 (CHEMBL1821780) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
Washington University Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE10A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assay				Eur J Med Chem 46: 3986-95 (2011) Article DOI: 10.1016/j.ejmech.2011.05.072 BindingDB Entry DOI: 10.7270/Q279452C
Washington University Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50351907 (CHEMBL1821781) Show SMILES COc1ccc(Br)cc1Cc1nccc2cc(OC)c(OCCF)cc12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	872	n/a	n/a	n/a	n/a	n/a	n/a
Washington University Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE10A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assay				Eur J Med Chem 46: 3986-95 (2011) Article DOI: 10.1016/j.ejmech.2011.05.072 BindingDB Entry DOI: 10.7270/Q279452C
Washington University Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (Homo sapiens (Human))	BDBM14754 (1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-isoq...) Show SMILES COc1ccc(Cc2nccc3cc(OC)c(OC)cc23)cc1OC Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	917	n/a	n/a	n/a	n/a	n/a	n/a
Washington University Curated by ChEMBL					Assay Description Inhibition of PDE3A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assay				Eur J Med Chem 46: 3986-95 (2011) Article DOI: 10.1016/j.ejmech.2011.05.072 BindingDB Entry DOI: 10.7270/Q279452C
Washington University Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B (Homo sapiens (Human))	BDBM14754 (1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-isoq...) Show SMILES COc1ccc(Cc2nccc3cc(OC)c(OC)cc23)cc1OC Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.03E+3	n/a	n/a	n/a	n/a	n/a	n/a
Washington University Curated by ChEMBL					Assay Description Inhibition of PDE3B assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assay				Eur J Med Chem 46: 3986-95 (2011) Article DOI: 10.1016/j.ejmech.2011.05.072 BindingDB Entry DOI: 10.7270/Q279452C
Washington University Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (Homo sapiens (Human))	BDBM50351895 (CHEMBL1821775) Show SMILES COc1ccc(Cc2nccc3cc(OCCF)c(OC)cc23)cc1C Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.19E+3	n/a	n/a	n/a	n/a	n/a	n/a
Washington University Curated by ChEMBL					Assay Description Inhibition of PDE3A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assay				Eur J Med Chem 46: 3986-95 (2011) Article DOI: 10.1016/j.ejmech.2011.05.072 BindingDB Entry DOI: 10.7270/Q279452C
Washington University Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B (Homo sapiens (Human))	BDBM50351908 (CHEMBL1821774) Show SMILES COc1ccc(Cc2nccc3cc(OCCF)c(OC)cc23)cc1F Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.25E+3	n/a	n/a	n/a	n/a	n/a	n/a
Washington University Curated by ChEMBL					Assay Description Inhibition of PDE3B assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assay				Eur J Med Chem 46: 3986-95 (2011) Article DOI: 10.1016/j.ejmech.2011.05.072 BindingDB Entry DOI: 10.7270/Q279452C
Washington University Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (Homo sapiens (Human))	BDBM50351908 (CHEMBL1821774) Show SMILES COc1ccc(Cc2nccc3cc(OCCF)c(OC)cc23)cc1F Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.29E+3	n/a	n/a	n/a	n/a	n/a	n/a
Washington University Curated by ChEMBL					Assay Description Inhibition of PDE3A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assay				Eur J Med Chem 46: 3986-95 (2011) Article DOI: 10.1016/j.ejmech.2011.05.072 BindingDB Entry DOI: 10.7270/Q279452C
Washington University Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B (Homo sapiens (Human))	BDBM50351895 (CHEMBL1821775) Show SMILES COc1ccc(Cc2nccc3cc(OCCF)c(OC)cc23)cc1C Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.67E+3	n/a	n/a	n/a	n/a	n/a	n/a
Washington University Curated by ChEMBL					Assay Description Inhibition of PDE3B assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assay				Eur J Med Chem 46: 3986-95 (2011) Article DOI: 10.1016/j.ejmech.2011.05.072 BindingDB Entry DOI: 10.7270/Q279452C
Washington University Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (Homo sapiens (Human))	BDBM50351894 (CHEMBL1821789) Show SMILES COc1cc(Cc2nccc3cc(OC)c(OC)cc23)ccc1OCCF Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.74E+3	n/a	n/a	n/a	n/a	n/a	n/a
Washington University Curated by ChEMBL					Assay Description Inhibition of PDE3A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assay				Eur J Med Chem 46: 3986-95 (2011) Article DOI: 10.1016/j.ejmech.2011.05.072 BindingDB Entry DOI: 10.7270/Q279452C
Washington University Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (Homo sapiens (Human))	BDBM50351890 (CHEMBL1821787) Show SMILES COc1ccc(Cc2nccc3cc(OC)c(OC)cc23)cc1OCCF Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.94E+3	n/a	n/a	n/a	n/a	n/a	n/a
Washington University Curated by ChEMBL					Assay Description Inhibition of PDE3A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assay				Eur J Med Chem 46: 3986-95 (2011) Article DOI: 10.1016/j.ejmech.2011.05.072 BindingDB Entry DOI: 10.7270/Q279452C
Washington University Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B (Homo sapiens (Human))	BDBM50351894 (CHEMBL1821789) Show SMILES COc1cc(Cc2nccc3cc(OC)c(OC)cc23)ccc1OCCF Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.17E+3	n/a	n/a	n/a	n/a	n/a	n/a
Washington University Curated by ChEMBL					Assay Description Inhibition of PDE3B assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assay				Eur J Med Chem 46: 3986-95 (2011) Article DOI: 10.1016/j.ejmech.2011.05.072 BindingDB Entry DOI: 10.7270/Q279452C
Washington University Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (Homo sapiens (Human))	BDBM50351891 (CHEMBL1821790) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Washington University Curated by ChEMBL					Assay Description Inhibition of PDE3A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assay				Eur J Med Chem 46: 3986-95 (2011) Article DOI: 10.1016/j.ejmech.2011.05.072 BindingDB Entry DOI: 10.7270/Q279452C
Washington University Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B (Homo sapiens (Human))	BDBM50351890 (CHEMBL1821787) Show SMILES COc1ccc(Cc2nccc3cc(OC)c(OC)cc23)cc1OCCF Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.51E+3	n/a	n/a	n/a	n/a	n/a	n/a
Washington University Curated by ChEMBL					Assay Description Inhibition of PDE3B assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assay				Eur J Med Chem 46: 3986-95 (2011) Article DOI: 10.1016/j.ejmech.2011.05.072 BindingDB Entry DOI: 10.7270/Q279452C
Washington University Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B (Homo sapiens (Human))	BDBM50351891 (CHEMBL1821790) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.52E+3	n/a	n/a	n/a	n/a	n/a	n/a
Washington University Curated by ChEMBL					Assay Description Inhibition of PDE3B assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assay				Eur J Med Chem 46: 3986-95 (2011) Article DOI: 10.1016/j.ejmech.2011.05.072 BindingDB Entry DOI: 10.7270/Q279452C
Washington University Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B (Homo sapiens (Human))	BDBM50351892 (CHEMBL1821791) Show SMILES COc1ccc(Cc2nccc3cc(OC)c(OC)cc23)cc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Washington University Curated by ChEMBL					Assay Description Inhibition of PDE3B assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assay				Eur J Med Chem 46: 3986-95 (2011) Article DOI: 10.1016/j.ejmech.2011.05.072 BindingDB Entry DOI: 10.7270/Q279452C
Washington University Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (Homo sapiens (Human))	BDBM50351892 (CHEMBL1821791) Show SMILES COc1ccc(Cc2nccc3cc(OC)c(OC)cc23)cc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.98E+3	n/a	n/a	n/a	n/a	n/a	n/a
Washington University Curated by ChEMBL					Assay Description Inhibition of PDE3A assessed as reduction in hydrolysis of [3H]cAMP by scintillation proximity assay				Eur J Med Chem 46: 3986-95 (2011) Article DOI: 10.1016/j.ejmech.2011.05.072 BindingDB Entry DOI: 10.7270/Q279452C
Washington University Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%