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PubMed code 2170651

Compile data set for download or QSAR
Found 13 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50013923
PNG
(3-(1-Butyl-4-methoxy-naphthalen-2-yl)-N-(1-methyl-...)
Show SMILES CCCCc1c(\C=C\C(=O)N[C@@H](C)CCCc2cccnc2)cc(OC)c2ccccc12
Show InChI InChI=1S/C28H34N2O2/c1-4-5-13-24-23(19-27(32-3)26-15-7-6-14-25(24)26)16-17-28(31)30-21(2)10-8-11-22-12-9-18-29-20-22/h6-7,9,12,14-21H,4-5,8,10-11,13H2,1-3H3,(H,30,31)/b17-16+/t21-/m0/s1
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n/an/a 1n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PAF binding to platelet activating factor receptor citrate-treated dog blood

J Med Chem 33: 2856-64 (1990)


BindingDB Entry DOI: 10.7270/Q21V5CZJ
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50013924
PNG
(3-(1-Butyl-4,7-dimethoxy-naphthalen-2-yl)-N-(1-met...)
Show SMILES CCCCc1c(\C=C\C(=O)N[C@@H](C)CCCc2cccnc2)cc(OC)c2ccc(OC)cc12
Show InChI InChI=1S/C29H36N2O3/c1-5-6-12-25-23(18-28(34-4)26-15-14-24(33-3)19-27(25)26)13-16-29(32)31-21(2)9-7-10-22-11-8-17-30-20-22/h8,11,13-21H,5-7,9-10,12H2,1-4H3,(H,31,32)/b16-13+/t21-/m0/s1
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n/an/a 3n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PAF binding to platelet activating factor receptor citrate-treated dog blood

J Med Chem 33: 2856-64 (1990)


BindingDB Entry DOI: 10.7270/Q21V5CZJ
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50013921
PNG
(3-(1-Butyl-5-methoxy-naphthalen-2-yl)-N-(1-methyl-...)
Show SMILES CCCCc1c(\C=C\C(=O)N[C@@H](C)CCCc2cccnc2)ccc2c(OC)cccc12
Show InChI InChI=1S/C28H34N2O2/c1-4-5-12-24-23(15-17-26-25(24)13-7-14-27(26)32-3)16-18-28(31)30-21(2)9-6-10-22-11-8-19-29-20-22/h7-8,11,13-21H,4-6,9-10,12H2,1-3H3,(H,30,31)/b18-16+/t21-/m0/s1
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n/an/a 6n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PAF binding to platelet activating factor receptor citrate-treated dog blood

J Med Chem 33: 2856-64 (1990)


BindingDB Entry DOI: 10.7270/Q21V5CZJ
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50013925
PNG
(3-(1-Butyl-6-methoxy-naphthalen-2-yl)-N-(1-methyl-...)
Show SMILES CCCCc1c(\C=C\C(=O)N[C@@H](C)CCCc2cccnc2)ccc2cc(OC)ccc12
Show InChI InChI=1S/C28H34N2O2/c1-4-5-11-26-23(12-13-24-19-25(32-3)15-16-27(24)26)14-17-28(31)30-21(2)8-6-9-22-10-7-18-29-20-22/h7,10,12-21H,4-6,8-9,11H2,1-3H3,(H,30,31)/b17-14+/t21-/m0/s1
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n/an/a 7n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PAF binding to platelet activating factor receptor citrate-treated dog blood

J Med Chem 33: 2856-64 (1990)


BindingDB Entry DOI: 10.7270/Q21V5CZJ
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50013922
PNG
(3-(1-Butyl-7-methoxy-naphthalen-2-yl)-N-(1-methyl-...)
Show SMILES CCCCc1c(\C=C\C(=O)N[C@@H](C)CCCc2cccnc2)ccc2ccc(OC)cc12
Show InChI InChI=1S/C28H34N2O2/c1-4-5-11-26-23(12-13-24-14-16-25(32-3)19-27(24)26)15-17-28(31)30-21(2)8-6-9-22-10-7-18-29-20-22/h7,10,12-21H,4-6,8-9,11H2,1-3H3,(H,30,31)/b17-15+/t21-/m0/s1
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n/an/a 15n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PAF binding to platelet activating factor receptor citrate-treated dog blood

J Med Chem 33: 2856-64 (1990)


BindingDB Entry DOI: 10.7270/Q21V5CZJ
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50013929
PNG
(3-(6-Methoxy-3-pentyl-benzo[b]thiophen-2-yl)-N-(1-...)
Show SMILES CCCCCc1c(\C=C\C(=O)N[C@@H](C)CCCc2cccnc2)sc2cc(OC)ccc12
Show InChI InChI=1S/C27H34N2O2S/c1-4-5-6-12-23-24-14-13-22(31-3)18-26(24)32-25(23)15-16-27(30)29-20(2)9-7-10-21-11-8-17-28-19-21/h8,11,13-20H,4-7,9-10,12H2,1-3H3,(H,29,30)/b16-15+/t20-/m0/s1
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n/an/a 24n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PAF binding to platelet activating factor receptor citrate-treated dog blood

J Med Chem 33: 2856-64 (1990)


BindingDB Entry DOI: 10.7270/Q21V5CZJ
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50013926
PNG
(CHEMBL319384 | N-(1-Ethyl-4-pyridin-3-yl-butyl)-3-...)
Show SMILES CCCCCc1c(\C=C\C(=O)N[C@@H](CC)CCCc2cccnc2)n(C)c2cc(OC)ccc12
Show InChI InChI=1S/C29H39N3O2/c1-5-7-8-14-25-26-16-15-24(34-4)20-28(26)32(3)27(25)17-18-29(33)31-23(6-2)13-9-11-22-12-10-19-30-21-22/h10,12,15-21,23H,5-9,11,13-14H2,1-4H3,(H,31,33)/b18-17+/t23-/m0/s1
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n/an/a 26n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PAF binding to platelet activating factor receptor citrate-treated dog blood

J Med Chem 33: 2856-64 (1990)


BindingDB Entry DOI: 10.7270/Q21V5CZJ
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50013933
PNG
(3-[6-Methoxy-1-(4-methoxy-phenyl)-3,4-dihydro-naph...)
Show SMILES COc1ccc(cc1)C1=C(CCc2cc(OC)ccc12)\C=C\C(=O)N[C@@H](C)CCCc1cccnc1 |t:9|
Show InChI InChI=1S/C31H34N2O3/c1-22(6-4-7-23-8-5-19-32-21-23)33-30(34)18-13-24-9-10-26-20-28(36-3)16-17-29(26)31(24)25-11-14-27(35-2)15-12-25/h5,8,11-22H,4,6-7,9-10H2,1-3H3,(H,33,34)/b18-13+/t22-/m0/s1
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n/an/a 30n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PAF binding to platelet activating factor receptor citrate-treated dog blood

J Med Chem 33: 2856-64 (1990)


BindingDB Entry DOI: 10.7270/Q21V5CZJ
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50013930
PNG
(3-(6-Methoxy-3-pentyl-1H-inden-2-yl)-N-(1-methyl-4...)
Show SMILES CCCCCC1=C(Cc2cc(OC)ccc12)\C=C\C(=O)N[C@@H](C)CCCc1cccnc1 |t:5|
Show InChI InChI=1S/C28H36N2O2/c1-4-5-6-12-26-23(18-24-19-25(32-3)14-15-27(24)26)13-16-28(31)30-21(2)9-7-10-22-11-8-17-29-20-22/h8,11,13-17,19-21H,4-7,9-10,12,18H2,1-3H3,(H,30,31)/b16-13+/t21-/m0/s1
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n/an/a 33n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PAF binding to platelet activating factor receptor citrate-treated dog blood

J Med Chem 33: 2856-64 (1990)


BindingDB Entry DOI: 10.7270/Q21V5CZJ
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50013927
PNG
(5-(4-Methoxy-phenyl)-deca-2,4-dienoic acid (1-meth...)
Show SMILES CCCCC\C(=C/C=C/C(=O)N[C@@H](C)CCCc1cccnc1)c1ccc(OC)cc1
Show InChI InChI=1S/C27H36N2O2/c1-4-5-6-13-24(25-16-18-26(31-3)19-17-25)14-8-15-27(30)29-22(2)10-7-11-23-12-9-20-28-21-23/h8-9,12,14-22H,4-7,10-11,13H2,1-3H3,(H,29,30)/b15-8+,24-14+/t22-/m0/s1
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n/an/a 40n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PAF binding to platelet activating factor receptor citrate-treated dog blood

J Med Chem 33: 2856-64 (1990)


BindingDB Entry DOI: 10.7270/Q21V5CZJ
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50013928
PNG
(3-(6-Methoxy-3-pentyl-benzofuran-2-yl)-N-(1-methyl...)
Show SMILES CCCCCc1c(\C=C\C(=O)N[C@@H](C)CCCc2cccnc2)oc2cc(OC)ccc12
Show InChI InChI=1S/C27H34N2O3/c1-4-5-6-12-23-24-14-13-22(31-3)18-26(24)32-25(23)15-16-27(30)29-20(2)9-7-10-21-11-8-17-28-19-21/h8,11,13-20H,4-7,9-10,12H2,1-3H3,(H,29,30)/b16-15+/t20-/m0/s1
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n/an/a 40n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PAF binding to platelet activating factor receptor citrate-treated dog blood

J Med Chem 33: 2856-64 (1990)


BindingDB Entry DOI: 10.7270/Q21V5CZJ
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50013931
PNG
(3-[6-Methoxy-1-(4-methoxy-phenyl)-naphthalen-2-yl]...)
Show SMILES COc1ccc(cc1)-c1c(\C=C\C(=O)N[C@@H](C)CCCc2cccnc2)ccc2cc(OC)ccc12
Show InChI InChI=1S/C31H32N2O3/c1-22(6-4-7-23-8-5-19-32-21-23)33-30(34)18-13-24-9-10-26-20-28(36-3)16-17-29(26)31(24)25-11-14-27(35-2)15-12-25/h5,8-22H,4,6-7H2,1-3H3,(H,33,34)/b18-13+/t22-/m0/s1
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n/an/a 55n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PAF binding to platelet activating factor receptor citrate-treated dog blood

J Med Chem 33: 2856-64 (1990)


BindingDB Entry DOI: 10.7270/Q21V5CZJ
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Homo sapiens (Human))		BDBM50013932
PNG
(3-(1-Butyl-6-methoxy-3,4-dihydro-naphthalen-2-yl)-...)
Show SMILES CCCCC1=C(CCc2cc(OC)ccc12)\C=C\C(=O)N[C@@H](C)CCCc1cccnc1 |t:4|
Show InChI InChI=1S/C28H36N2O2/c1-4-5-11-26-23(12-13-24-19-25(32-3)15-16-27(24)26)14-17-28(31)30-21(2)8-6-9-22-10-7-18-29-20-22/h7,10,14-21H,4-6,8-9,11-13H2,1-3H3,(H,30,31)/b17-14+/t21-/m0/s1
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n/an/a 90n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PAF binding to platelet activating factor receptor citrate-treated dog blood

J Med Chem 33: 2856-64 (1990)


BindingDB Entry DOI: 10.7270/Q21V5CZJ
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%