Found 9 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Ribosyldihydronicotinamide dehydrogenase [quinone]
(Homo sapiens (Human)) | BDBM92771
(Indolequinone, compd 5)Show SMILES CN(C)CCC=Nc1cc(O)c2n(C)c(C)c(COc3c(F)cc(F)cc3F)c2c1O |w:6.6| Show InChI InChI=1S/C22H24F3N3O3/c1-12-14(11-31-22-15(24)8-13(23)9-16(22)25)19-20(28(12)4)18(29)10-17(21(19)30)26-6-5-7-27(2)3/h6,8-10,29-30H,5,7,11H2,1-4H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Colorado Denver
| Assay Description
Cell assay using human leukemia cell line K562. |
Biochemistry 50: 6678-88 (2011)
Article DOI: 10.1021/bi2002967
BindingDB Entry DOI: 10.7270/Q2H130MT |
More data for this
Ligand-Target Pair | |
Ribosyldihydronicotinamide dehydrogenase [quinone]
(Homo sapiens (Human)) | BDBM92774
(Indolequinone, compd 8)Show SMILES CN(C)CCC=Nc1cc(O)c2n(C)c(C)c(COc3ccccc3)c2c1O |w:6.6| Show InChI InChI=1S/C22H27N3O3/c1-15-17(14-28-16-9-6-5-7-10-16)20-21(25(15)4)19(26)13-18(22(20)27)23-11-8-12-24(2)3/h5-7,9-11,13,26-27H,8,12,14H2,1-4H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Colorado Denver
| Assay Description
Cell assay using human leukemia cell line K562. |
Biochemistry 50: 6678-88 (2011)
Article DOI: 10.1021/bi2002967
BindingDB Entry DOI: 10.7270/Q2H130MT |
More data for this
Ligand-Target Pair | |
Ribosyldihydronicotinamide dehydrogenase [quinone]
(Homo sapiens (Human)) | BDBM92772
(Indolequinone, compd 6)Show SMILES CN(C)CCC=Nc1cc(O)c2c(COc3c(F)cc(F)cc3F)c(C)n(C)c2c1O |w:6.6| Show InChI InChI=1S/C22H24F3N3O3/c1-12-14(11-31-22-15(24)8-13(23)9-16(22)25)19-18(29)10-17(21(30)20(19)28(12)4)26-6-5-7-27(2)3/h6,8-10,29-30H,5,7,11H2,1-4H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Colorado Denver
| Assay Description
Cell assay using human leukemia cell line K562. |
Biochemistry 50: 6678-88 (2011)
Article DOI: 10.1021/bi2002967
BindingDB Entry DOI: 10.7270/Q2H130MT |
More data for this
Ligand-Target Pair | |
Ribosyldihydronicotinamide dehydrogenase [quinone]
(Homo sapiens (Human)) | BDBM92767
(Indolequinone, compd 1)Show SMILES Cc1c(COc2ccc(cc2)N(=O)=O)c2c(O)c(cc(O)c2n1C)N=CCCCN |w:24.26| Show InChI InChI=1S/C21H24N4O5/c1-13-16(12-30-15-7-5-14(6-8-15)25(28)29)19-20(24(13)2)18(26)11-17(21(19)27)23-10-4-3-9-22/h5-8,10-11,26-27H,3-4,9,12,22H2,1-2H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| KEGG
MMDB
PC cid
PC sid
UniChem
Similars
| MMDB
Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Colorado Denver
| Assay Description
Cell assay using human leukemia cell line K562. |
Biochemistry 50: 6678-88 (2011)
Article DOI: 10.1021/bi2002967
BindingDB Entry DOI: 10.7270/Q2H130MT |
More data for this
Ligand-Target Pair | |
Ribosyldihydronicotinamide dehydrogenase [quinone]
(Homo sapiens (Human)) | BDBM92775
(Indolequinone, compd 9)Show SMILES CN(C)CCC=Nc1cc(O)c2n(C)c(C)c(CO)c2c1O |w:6.6| Show InChI InChI=1S/C16H23N3O3/c1-10-11(9-20)14-15(19(10)4)13(21)8-12(16(14)22)17-6-5-7-18(2)3/h6,8,20-22H,5,7,9H2,1-4H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Colorado Denver
| Assay Description
Cell assay using human leukemia cell line K562. |
Biochemistry 50: 6678-88 (2011)
Article DOI: 10.1021/bi2002967
BindingDB Entry DOI: 10.7270/Q2H130MT |
More data for this
Ligand-Target Pair | |
Ribosyldihydronicotinamide dehydrogenase [quinone]
(Homo sapiens (Human)) | BDBM92769
(Indolequinone, compd 3)Show SMILES Cc1c(COc2c(F)cc(F)cc2F)c2c(O)cc(N=CCCCN)c(O)c2n1C |w:19.19| Show InChI InChI=1S/C21H22F3N3O3/c1-11-13(10-30-21-14(23)7-12(22)8-15(21)24)18-17(28)9-16(26-6-4-3-5-25)20(29)19(18)27(11)2/h6-9,28-29H,3-5,10,25H2,1-2H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Colorado Denver
| Assay Description
Cell assay using human leukemia cell line K562. |
Biochemistry 50: 6678-88 (2011)
Article DOI: 10.1021/bi2002967
BindingDB Entry DOI: 10.7270/Q2H130MT |
More data for this
Ligand-Target Pair | |
Ribosyldihydronicotinamide dehydrogenase [quinone]
(Homo sapiens (Human)) | BDBM92770
(Indolequinone, compd 4)Show SMILES Cc1c(COc2c(F)cc(F)cc2F)c2c(O)c(cc(O)c2n1C)N=CCCN |w:24.26| Show InChI InChI=1S/C20H20F3N3O3/c1-10-12(9-29-20-13(22)6-11(21)7-14(20)23)17-18(26(10)2)16(27)8-15(19(17)28)25-5-3-4-24/h5-8,27-28H,3-4,9,24H2,1-2H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Colorado Denver
| Assay Description
Cell assay using human leukemia cell line K562. |
Biochemistry 50: 6678-88 (2011)
Article DOI: 10.1021/bi2002967
BindingDB Entry DOI: 10.7270/Q2H130MT |
More data for this
Ligand-Target Pair | |
Ribosyldihydronicotinamide dehydrogenase [quinone]
(Homo sapiens (Human)) | BDBM92773
(Indolequinone, compd 7)Show SMILES CN(C)CCCN(C)C1=CC(=O)c2c(c(COc3c(F)cc(F)cc3F)c(C)n2C)C1=O |t:8| Show InChI InChI=1S/C23H26F3N3O3/c1-13-15(12-32-23-16(25)9-14(24)10-17(23)26)20-21(29(13)5)19(30)11-18(22(20)31)28(4)8-6-7-27(2)3/h9-11H,6-8,12H2,1-5H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Colorado Denver
| Assay Description
Cell assay using human leukemia cell line K562. |
Biochemistry 50: 6678-88 (2011)
Article DOI: 10.1021/bi2002967
BindingDB Entry DOI: 10.7270/Q2H130MT |
More data for this
Ligand-Target Pair | |
Ribosyldihydronicotinamide dehydrogenase [quinone]
(Homo sapiens (Human)) | BDBM92768
(Indolequinone, compd 2)Show SMILES Cc1c(COc2c(F)cc(F)cc2F)c2c(O)c(cc(O)c2n1C)N=CCCCN |w:24.26| Show InChI InChI=1S/C21H22F3N3O3/c1-11-13(10-30-21-14(23)7-12(22)8-15(21)24)18-19(27(11)2)17(28)9-16(20(18)29)26-6-4-3-5-25/h6-9,28-29H,3-5,10,25H2,1-2H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Colorado Denver
| Assay Description
Cell assay using human leukemia cell line K562. |
Biochemistry 50: 6678-88 (2011)
Article DOI: 10.1021/bi2002967
BindingDB Entry DOI: 10.7270/Q2H130MT |
More data for this
Ligand-Target Pair | |
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