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PubMed code 21741249

Compile data set for download or QSAR
Found 32 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM50350424
PNG
(CHEMBL454440)
Show SMILES Cc1c(O)c(O)cc2oc3cc(O)cc(O)c3c(=O)c12
Show InChI InChI=1S/C14H10O6/c1-5-11-10(4-8(17)13(5)18)20-9-3-6(15)2-7(16)12(9)14(11)19/h2-4,15-18H,1H3
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n/an/a 300n/an/an/an/an/an/a



Heinrich-Heine-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of recombinant PIM1 assessed as 33Pi incorporation after 60 mins by scintillation counting


Bioorg Med Chem 19: 4644-51 (2011)


Article DOI: 10.1016/j.bmc.2011.06.013
BindingDB Entry DOI: 10.7270/Q2X92BNH
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM50350423
PNG
(CHEMBL466154)
Show SMILES Cc1cc(O)cc2oc3cc(O)cc(O)c3c(=O)c12
Show InChI InChI=1S/C14H10O5/c1-6-2-7(15)4-10-12(6)14(18)13-9(17)3-8(16)5-11(13)19-10/h2-5,15-17H,1H3
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n/an/a 300n/an/an/an/an/an/a



Heinrich-Heine-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of recombinant PIM1 assessed as 33Pi incorporation after 60 mins by scintillation counting


Bioorg Med Chem 19: 4644-51 (2011)


Article DOI: 10.1016/j.bmc.2011.06.013
BindingDB Entry DOI: 10.7270/Q2X92BNH
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50350424
PNG
(CHEMBL454440)
Show SMILES Cc1c(O)c(O)cc2oc3cc(O)cc(O)c3c(=O)c12
Show InChI InChI=1S/C14H10O6/c1-5-11-10(4-8(17)13(5)18)20-9-3-6(15)2-7(16)12(9)14(11)19/h2-4,15-18H,1H3
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n/an/a 500n/an/an/an/an/an/a



Heinrich-Heine-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of recombinant Aurora-b assessed as 33Pi incorporation after 60 mins by scintillation counting


Bioorg Med Chem 19: 4644-51 (2011)


Article DOI: 10.1016/j.bmc.2011.06.013
BindingDB Entry DOI: 10.7270/Q2X92BNH
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50350424
PNG
(CHEMBL454440)
Show SMILES Cc1c(O)c(O)cc2oc3cc(O)cc(O)c3c(=O)c12
Show InChI InChI=1S/C14H10O6/c1-5-11-10(4-8(17)13(5)18)20-9-3-6(15)2-7(16)12(9)14(11)19/h2-4,15-18H,1H3
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n/an/a 800n/an/an/an/an/an/a



Heinrich-Heine-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of recombinant VEGF-R2 assessed as 33Pi incorporation after 60 mins by scintillation counting


Bioorg Med Chem 19: 4644-51 (2011)


Article DOI: 10.1016/j.bmc.2011.06.013
BindingDB Entry DOI: 10.7270/Q2X92BNH
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50350424
PNG
(CHEMBL454440)
Show SMILES Cc1c(O)c(O)cc2oc3cc(O)cc(O)c3c(=O)c12
Show InChI InChI=1S/C14H10O6/c1-5-11-10(4-8(17)13(5)18)20-9-3-6(15)2-7(16)12(9)14(11)19/h2-4,15-18H,1H3
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n/an/a 1.10E+3n/an/an/an/an/an/a



Heinrich-Heine-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of recombinant ALK assessed as 33Pi incorporation after 60 mins by scintillation counting


Bioorg Med Chem 19: 4644-51 (2011)


Article DOI: 10.1016/j.bmc.2011.06.013
BindingDB Entry DOI: 10.7270/Q2X92BNH
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50350423
PNG
(CHEMBL466154)
Show SMILES Cc1cc(O)cc2oc3cc(O)cc(O)c3c(=O)c12
Show InChI InChI=1S/C14H10O5/c1-6-2-7(15)4-10-12(6)14(18)13-9(17)3-8(16)5-11(13)19-10/h2-5,15-17H,1H3
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n/an/a 3.00E+3n/an/an/an/an/an/a



Heinrich-Heine-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of recombinant Aurora-b assessed as 33Pi incorporation after 60 mins by scintillation counting


Bioorg Med Chem 19: 4644-51 (2011)


Article DOI: 10.1016/j.bmc.2011.06.013
BindingDB Entry DOI: 10.7270/Q2X92BNH
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50350424
PNG
(CHEMBL454440)
Show SMILES Cc1c(O)c(O)cc2oc3cc(O)cc(O)c3c(=O)c12
Show InChI InChI=1S/C14H10O6/c1-5-11-10(4-8(17)13(5)18)20-9-3-6(15)2-7(16)12(9)14(11)19/h2-4,15-18H,1H3
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n/an/a 4.40E+3n/an/an/an/an/an/a



Heinrich-Heine-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of wild type MET assessed as 33Pi incorporation after 60 mins by scintillation counting


Bioorg Med Chem 19: 4644-51 (2011)


Article DOI: 10.1016/j.bmc.2011.06.013
BindingDB Entry DOI: 10.7270/Q2X92BNH
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM50350424
PNG
(CHEMBL454440)
Show SMILES Cc1c(O)c(O)cc2oc3cc(O)cc(O)c3c(=O)c12
Show InChI InChI=1S/C14H10O6/c1-5-11-10(4-8(17)13(5)18)20-9-3-6(15)2-7(16)12(9)14(11)19/h2-4,15-18H,1H3
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n/an/a 6.60E+3n/an/an/an/an/an/a



Heinrich-Heine-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of recombinant AXL assessed as 33Pi incorporation after 60 mins by scintillation counting


Bioorg Med Chem 19: 4644-51 (2011)


Article DOI: 10.1016/j.bmc.2011.06.013
BindingDB Entry DOI: 10.7270/Q2X92BNH
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50350424
PNG
(CHEMBL454440)
Show SMILES Cc1c(O)c(O)cc2oc3cc(O)cc(O)c3c(=O)c12
Show InChI InChI=1S/C14H10O6/c1-5-11-10(4-8(17)13(5)18)20-9-3-6(15)2-7(16)12(9)14(11)19/h2-4,15-18H,1H3
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n/an/a 8.60E+3n/an/an/an/an/an/a



Heinrich-Heine-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of recombinant IGF1-R assessed as 33Pi incorporation after 60 mins by scintillation counting


Bioorg Med Chem 19: 4644-51 (2011)


Article DOI: 10.1016/j.bmc.2011.06.013
BindingDB Entry DOI: 10.7270/Q2X92BNH
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))
BDBM50350424
PNG
(CHEMBL454440)
Show SMILES Cc1c(O)c(O)cc2oc3cc(O)cc(O)c3c(=O)c12
Show InChI InChI=1S/C14H10O6/c1-5-11-10(4-8(17)13(5)18)20-9-3-6(15)2-7(16)12(9)14(11)19/h2-4,15-18H,1H3
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n/an/a 8.80E+3n/an/an/an/an/an/a



Heinrich-Heine-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of recombinant PLK1 assessed as 33Pi incorporation after 60 mins by scintillation counting


Bioorg Med Chem 19: 4644-51 (2011)


Article DOI: 10.1016/j.bmc.2011.06.013
BindingDB Entry DOI: 10.7270/Q2X92BNH
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50350423
PNG
(CHEMBL466154)
Show SMILES Cc1cc(O)cc2oc3cc(O)cc(O)c3c(=O)c12
Show InChI InChI=1S/C14H10O5/c1-6-2-7(15)4-10-12(6)14(18)13-9(17)3-8(16)5-11(13)19-10/h2-5,15-17H,1H3
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n/an/a 1.17E+4n/an/an/an/an/an/a



Heinrich-Heine-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of recombinant VEGF-R2 assessed as 33Pi incorporation after 60 mins by scintillation counting


Bioorg Med Chem 19: 4644-51 (2011)


Article DOI: 10.1016/j.bmc.2011.06.013
BindingDB Entry DOI: 10.7270/Q2X92BNH
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50350424
PNG
(CHEMBL454440)
Show SMILES Cc1c(O)c(O)cc2oc3cc(O)cc(O)c3c(=O)c12
Show InChI InChI=1S/C14H10O6/c1-5-11-10(4-8(17)13(5)18)20-9-3-6(15)2-7(16)12(9)14(11)19/h2-4,15-18H,1H3
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n/an/a 1.29E+4n/an/an/an/an/an/a



Heinrich-Heine-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of recombinant SRC assessed as 33Pi incorporation after 60 mins by scintillation counting


Bioorg Med Chem 19: 4644-51 (2011)


Article DOI: 10.1016/j.bmc.2011.06.013
BindingDB Entry DOI: 10.7270/Q2X92BNH
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))
BDBM50350424
PNG
(CHEMBL454440)
Show SMILES Cc1c(O)c(O)cc2oc3cc(O)cc(O)c3c(=O)c12
Show InChI InChI=1S/C14H10O6/c1-5-11-10(4-8(17)13(5)18)20-9-3-6(15)2-7(16)12(9)14(11)19/h2-4,15-18H,1H3
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n/an/a 1.52E+4n/an/an/an/an/an/a



Heinrich-Heine-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of recombinant FAK assessed as 33Pi incorporation after 60 mins by scintillation counting


Bioorg Med Chem 19: 4644-51 (2011)


Article DOI: 10.1016/j.bmc.2011.06.013
BindingDB Entry DOI: 10.7270/Q2X92BNH
More data for this
Ligand-Target Pair
NUAK family SNF1-like kinase 1


(Homo sapiens (Human))
BDBM50350424
PNG
(CHEMBL454440)
Show SMILES Cc1c(O)c(O)cc2oc3cc(O)cc(O)c3c(=O)c12
Show InChI InChI=1S/C14H10O6/c1-5-11-10(4-8(17)13(5)18)20-9-3-6(15)2-7(16)12(9)14(11)19/h2-4,15-18H,1H3
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n/an/a 1.56E+4n/an/an/an/an/an/a



Heinrich-Heine-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of recombinant ARK5 assessed as 33Pi incorporation after 60 mins by scintillation counting


Bioorg Med Chem 19: 4644-51 (2011)


Article DOI: 10.1016/j.bmc.2011.06.013
BindingDB Entry DOI: 10.7270/Q2X92BNH
More data for this
Ligand-Target Pair
NUAK family SNF1-like kinase 1


(Homo sapiens (Human))
BDBM50350423
PNG
(CHEMBL466154)
Show SMILES Cc1cc(O)cc2oc3cc(O)cc(O)c3c(=O)c12
Show InChI InChI=1S/C14H10O5/c1-6-2-7(15)4-10-12(6)14(18)13-9(17)3-8(16)5-11(13)19-10/h2-5,15-17H,1H3
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n/an/a 3.30E+4n/an/an/an/an/an/a



Heinrich-Heine-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of recombinant ARK5 assessed as 33Pi incorporation after 60 mins by scintillation counting


Bioorg Med Chem 19: 4644-51 (2011)


Article DOI: 10.1016/j.bmc.2011.06.013
BindingDB Entry DOI: 10.7270/Q2X92BNH
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50350423
PNG
(CHEMBL466154)
Show SMILES Cc1cc(O)cc2oc3cc(O)cc(O)c3c(=O)c12
Show InChI InChI=1S/C14H10O5/c1-6-2-7(15)4-10-12(6)14(18)13-9(17)3-8(16)5-11(13)19-10/h2-5,15-17H,1H3
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n/an/a 3.33E+4n/an/an/an/an/an/a



Heinrich-Heine-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of recombinant IGF1-R assessed as 33Pi incorporation after 60 mins by scintillation counting


Bioorg Med Chem 19: 4644-51 (2011)


Article DOI: 10.1016/j.bmc.2011.06.013
BindingDB Entry DOI: 10.7270/Q2X92BNH
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50350423
PNG
(CHEMBL466154)
Show SMILES Cc1cc(O)cc2oc3cc(O)cc(O)c3c(=O)c12
Show InChI InChI=1S/C14H10O5/c1-6-2-7(15)4-10-12(6)14(18)13-9(17)3-8(16)5-11(13)19-10/h2-5,15-17H,1H3
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n/an/a 3.50E+4n/an/an/an/an/an/a



Heinrich-Heine-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of recombinant SRC assessed as 33Pi incorporation after 60 mins by scintillation counting


Bioorg Med Chem 19: 4644-51 (2011)


Article DOI: 10.1016/j.bmc.2011.06.013
BindingDB Entry DOI: 10.7270/Q2X92BNH
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50350423
PNG
(CHEMBL466154)
Show SMILES Cc1cc(O)cc2oc3cc(O)cc(O)c3c(=O)c12
Show InChI InChI=1S/C14H10O5/c1-6-2-7(15)4-10-12(6)14(18)13-9(17)3-8(16)5-11(13)19-10/h2-5,15-17H,1H3
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n/an/a 4.13E+4n/an/an/an/an/an/a



Heinrich-Heine-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of recombinant ALK assessed as 33Pi incorporation after 60 mins by scintillation counting


Bioorg Med Chem 19: 4644-51 (2011)


Article DOI: 10.1016/j.bmc.2011.06.013
BindingDB Entry DOI: 10.7270/Q2X92BNH
More data for this
Ligand-Target Pair
Protein kinase N1


(Homo sapiens (Human))
BDBM50350424
PNG
(CHEMBL454440)
Show SMILES Cc1c(O)c(O)cc2oc3cc(O)cc(O)c3c(=O)c12
Show InChI InChI=1S/C14H10O6/c1-5-11-10(4-8(17)13(5)18)20-9-3-6(15)2-7(16)12(9)14(11)19/h2-4,15-18H,1H3
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n/an/a 4.53E+4n/an/an/an/an/an/a



Heinrich-Heine-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of recombinant PRK1 assessed as 33Pi incorporation after 60 mins by scintillation counting


Bioorg Med Chem 19: 4644-51 (2011)


Article DOI: 10.1016/j.bmc.2011.06.013
BindingDB Entry DOI: 10.7270/Q2X92BNH
More data for this
Ligand-Target Pair
Protein kinase N1


(Homo sapiens (Human))
BDBM50350423
PNG
(CHEMBL466154)
Show SMILES Cc1cc(O)cc2oc3cc(O)cc(O)c3c(=O)c12
Show InChI InChI=1S/C14H10O5/c1-6-2-7(15)4-10-12(6)14(18)13-9(17)3-8(16)5-11(13)19-10/h2-5,15-17H,1H3
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n/an/a 5.49E+4n/an/an/an/an/an/a



Heinrich-Heine-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of recombinant PRK1 assessed as 33Pi incorporation after 60 mins by scintillation counting


Bioorg Med Chem 19: 4644-51 (2011)


Article DOI: 10.1016/j.bmc.2011.06.013
BindingDB Entry DOI: 10.7270/Q2X92BNH
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase NEK6


(Homo sapiens (Human))
BDBM50350424
PNG
(CHEMBL454440)
Show SMILES Cc1c(O)c(O)cc2oc3cc(O)cc(O)c3c(=O)c12
Show InChI InChI=1S/C14H10O6/c1-5-11-10(4-8(17)13(5)18)20-9-3-6(15)2-7(16)12(9)14(11)19/h2-4,15-18H,1H3
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n/an/a 6.78E+4n/an/an/an/an/an/a



Heinrich-Heine-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of recombinant NEK6 assessed as 33Pi incorporation after 60 mins by scintillation counting


Bioorg Med Chem 19: 4644-51 (2011)


Article DOI: 10.1016/j.bmc.2011.06.013
BindingDB Entry DOI: 10.7270/Q2X92BNH
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))
BDBM50350423
PNG
(CHEMBL466154)
Show SMILES Cc1cc(O)cc2oc3cc(O)cc(O)c3c(=O)c12
Show InChI InChI=1S/C14H10O5/c1-6-2-7(15)4-10-12(6)14(18)13-9(17)3-8(16)5-11(13)19-10/h2-5,15-17H,1H3
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n/an/a 7.57E+4n/an/an/an/an/an/a



Heinrich-Heine-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of recombinant PLK1 assessed as 33Pi incorporation after 60 mins by scintillation counting


Bioorg Med Chem 19: 4644-51 (2011)


Article DOI: 10.1016/j.bmc.2011.06.013
BindingDB Entry DOI: 10.7270/Q2X92BNH
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Nek2


(Homo sapiens (Human))
BDBM50350424
PNG
(CHEMBL454440)
Show SMILES Cc1c(O)c(O)cc2oc3cc(O)cc(O)c3c(=O)c12
Show InChI InChI=1S/C14H10O6/c1-5-11-10(4-8(17)13(5)18)20-9-3-6(15)2-7(16)12(9)14(11)19/h2-4,15-18H,1H3
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n/an/a 8.39E+4n/an/an/an/an/an/a



Heinrich-Heine-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of recombinant NEK2 assessed as 33Pi incorporation after 60 mins by scintillation counting


Bioorg Med Chem 19: 4644-51 (2011)


Article DOI: 10.1016/j.bmc.2011.06.013
BindingDB Entry DOI: 10.7270/Q2X92BNH
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Nek2


(Homo sapiens (Human))
BDBM50350423
PNG
(CHEMBL466154)
Show SMILES Cc1cc(O)cc2oc3cc(O)cc(O)c3c(=O)c12
Show InChI InChI=1S/C14H10O5/c1-6-2-7(15)4-10-12(6)14(18)13-9(17)3-8(16)5-11(13)19-10/h2-5,15-17H,1H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Heinrich-Heine-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of recombinant NEK2 assessed as 33Pi incorporation after 60 mins by scintillation counting


Bioorg Med Chem 19: 4644-51 (2011)


Article DOI: 10.1016/j.bmc.2011.06.013
BindingDB Entry DOI: 10.7270/Q2X92BNH
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))
BDBM50350423
PNG
(CHEMBL466154)
Show SMILES Cc1cc(O)cc2oc3cc(O)cc(O)c3c(=O)c12
Show InChI InChI=1S/C14H10O5/c1-6-2-7(15)4-10-12(6)14(18)13-9(17)3-8(16)5-11(13)19-10/h2-5,15-17H,1H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Heinrich-Heine-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of recombinant FAK assessed as 33Pi incorporation after 60 mins by scintillation counting


Bioorg Med Chem 19: 4644-51 (2011)


Article DOI: 10.1016/j.bmc.2011.06.013
BindingDB Entry DOI: 10.7270/Q2X92BNH
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase NEK6


(Homo sapiens (Human))
BDBM50350423
PNG
(CHEMBL466154)
Show SMILES Cc1cc(O)cc2oc3cc(O)cc(O)c3c(=O)c12
Show InChI InChI=1S/C14H10O5/c1-6-2-7(15)4-10-12(6)14(18)13-9(17)3-8(16)5-11(13)19-10/h2-5,15-17H,1H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Heinrich-Heine-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of recombinant NEK6 assessed as 33Pi incorporation after 60 mins by scintillation counting


Bioorg Med Chem 19: 4644-51 (2011)


Article DOI: 10.1016/j.bmc.2011.06.013
BindingDB Entry DOI: 10.7270/Q2X92BNH
More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1


(Homo sapiens (Human))
BDBM50350424
PNG
(CHEMBL454440)
Show SMILES Cc1c(O)c(O)cc2oc3cc(O)cc(O)c3c(=O)c12
Show InChI InChI=1S/C14H10O6/c1-5-11-10(4-8(17)13(5)18)20-9-3-6(15)2-7(16)12(9)14(11)19/h2-4,15-18H,1H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Heinrich-Heine-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of wild type MEK1 assessed as 33Pi incorporation after 60 mins by scintillation counting


Bioorg Med Chem 19: 4644-51 (2011)


Article DOI: 10.1016/j.bmc.2011.06.013
BindingDB Entry DOI: 10.7270/Q2X92BNH
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM50350423
PNG
(CHEMBL466154)
Show SMILES Cc1cc(O)cc2oc3cc(O)cc(O)c3c(=O)c12
Show InChI InChI=1S/C14H10O5/c1-6-2-7(15)4-10-12(6)14(18)13-9(17)3-8(16)5-11(13)19-10/h2-5,15-17H,1H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Heinrich-Heine-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of recombinant AXL assessed as 33Pi incorporation after 60 mins by scintillation counting


Bioorg Med Chem 19: 4644-51 (2011)


Article DOI: 10.1016/j.bmc.2011.06.013
BindingDB Entry DOI: 10.7270/Q2X92BNH
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM50350424
PNG
(CHEMBL454440)
Show SMILES Cc1c(O)c(O)cc2oc3cc(O)cc(O)c3c(=O)c12
Show InChI InChI=1S/C14H10O6/c1-5-11-10(4-8(17)13(5)18)20-9-3-6(15)2-7(16)12(9)14(11)19/h2-4,15-18H,1H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Heinrich-Heine-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of recombinant AKT1 assessed as 33Pi incorporation after 60 mins by scintillation counting


Bioorg Med Chem 19: 4644-51 (2011)


Article DOI: 10.1016/j.bmc.2011.06.013
BindingDB Entry DOI: 10.7270/Q2X92BNH
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM50350423
PNG
(CHEMBL466154)
Show SMILES Cc1cc(O)cc2oc3cc(O)cc(O)c3c(=O)c12
Show InChI InChI=1S/C14H10O5/c1-6-2-7(15)4-10-12(6)14(18)13-9(17)3-8(16)5-11(13)19-10/h2-5,15-17H,1H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Heinrich-Heine-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of recombinant AKT1 assessed as 33Pi incorporation after 60 mins by scintillation counting


Bioorg Med Chem 19: 4644-51 (2011)


Article DOI: 10.1016/j.bmc.2011.06.013
BindingDB Entry DOI: 10.7270/Q2X92BNH
More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1


(Homo sapiens (Human))
BDBM50350423
PNG
(CHEMBL466154)
Show SMILES Cc1cc(O)cc2oc3cc(O)cc(O)c3c(=O)c12
Show InChI InChI=1S/C14H10O5/c1-6-2-7(15)4-10-12(6)14(18)13-9(17)3-8(16)5-11(13)19-10/h2-5,15-17H,1H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Heinrich-Heine-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of wild type MEK1 assessed as 33Pi incorporation after 60 mins by scintillation counting


Bioorg Med Chem 19: 4644-51 (2011)


Article DOI: 10.1016/j.bmc.2011.06.013
BindingDB Entry DOI: 10.7270/Q2X92BNH
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50350423
PNG
(CHEMBL466154)
Show SMILES Cc1cc(O)cc2oc3cc(O)cc(O)c3c(=O)c12
Show InChI InChI=1S/C14H10O5/c1-6-2-7(15)4-10-12(6)14(18)13-9(17)3-8(16)5-11(13)19-10/h2-5,15-17H,1H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Heinrich-Heine-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of wild type MET assessed as 33Pi incorporation after 60 mins by scintillation counting


Bioorg Med Chem 19: 4644-51 (2011)


Article DOI: 10.1016/j.bmc.2011.06.013
BindingDB Entry DOI: 10.7270/Q2X92BNH
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%