Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Prostaglandin G/H synthase 1 (Homo sapiens (Human)) | BDBM17638 (2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 34 | n/a | n/a | n/a | n/a | n/a | n/a |
RWTH Aachen University Curated by ChEMBL | Assay Description Inhibition of human platelets COX1 assessed as PGE2 production using arachidonic acid as substrate preincubated for 15 mins measured after 15 mins by... | Bioorg Med Chem Lett 21: 4888-90 (2011) Article DOI: 10.1016/j.bmcl.2011.06.029 BindingDB Entry DOI: 10.7270/Q2J38SX8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin G/H synthase 1 (Homo sapiens (Human)) | BDBM50350507 (CHEMBL1814813) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 42 | n/a | n/a | n/a | n/a | n/a | n/a |
RWTH Aachen University Curated by ChEMBL | Assay Description Inhibition of human platelets COX1 assessed as PGE2 production using arachidonic acid as substrate preincubated for 15 mins measured after 15 mins by... | Bioorg Med Chem Lett 21: 4888-90 (2011) Article DOI: 10.1016/j.bmcl.2011.06.029 BindingDB Entry DOI: 10.7270/Q2J38SX8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin G/H synthase 2 (Homo sapiens (Human)) | BDBM50350507 (CHEMBL1814813) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 156 | n/a | n/a | n/a | n/a | n/a | n/a |
RWTH Aachen University Curated by ChEMBL | Assay Description Inhibition of human recombinant COX2 expressed in Sf21 cells assessed as PGE2 production using arachidonic acid as substrate preincubated for 15 mins... | Bioorg Med Chem Lett 21: 4888-90 (2011) Article DOI: 10.1016/j.bmcl.2011.06.029 BindingDB Entry DOI: 10.7270/Q2J38SX8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin G/H synthase 2 (Homo sapiens (Human)) | BDBM22369 (4-(4-methanesulfonylphenyl)-3-phenyl-2,5-dihydrofu...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 156 | n/a | n/a | n/a | n/a | n/a | n/a |
RWTH Aachen University Curated by ChEMBL | Assay Description Inhibition of human recombinant COX2 expressed in Sf21 cells assessed as PGE2 production using arachidonic acid as substrate preincubated for 15 mins... | Bioorg Med Chem Lett 21: 4888-90 (2011) Article DOI: 10.1016/j.bmcl.2011.06.029 BindingDB Entry DOI: 10.7270/Q2J38SX8 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human)) | BDBM50350507 (CHEMBL1814813) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
RWTH Aachen University Curated by ChEMBL | Assay Description Inhibition of human ERG expressed in HEK293 cells assessed as inhibition of tail current at holding potential of -70 mV after 10 mins by whole-cell p... | Bioorg Med Chem Lett 21: 4888-90 (2011) Article DOI: 10.1016/j.bmcl.2011.06.029 BindingDB Entry DOI: 10.7270/Q2J38SX8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human)) | BDBM50419031 (CHEMBL2029168) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
RWTH Aachen University Curated by ChEMBL | Assay Description Inhibition of human ERG expressed in HEK293 cells assessed as inhibition of tail current at holding potential of -70 mV after 10 mins by whole-cell p... | Bioorg Med Chem Lett 21: 4888-90 (2011) Article DOI: 10.1016/j.bmcl.2011.06.029 BindingDB Entry DOI: 10.7270/Q2J38SX8 | |||||||||||
More data for this Ligand-Target Pair |