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PubMed code 21764590

Compile data set for download or QSAR
Found 98 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
72 kDa type IV collagenase


(Homo sapiens (Human))		BDBM50350604
PNG
(CHEMBL1812922)
Show SMILES O=C1NC(=O)C(N2CCCN(CC3CC3)CC2)(C(=O)N1)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C25H28N4O4/c30-22-25(23(31)27-24(32)26-22,29-14-4-13-28(15-16-29)17-18-7-8-18)19-9-11-21(12-10-19)33-20-5-2-1-3-6-20/h1-3,5-6,9-12,18H,4,7-8,13-17H2,(H2,26,27,30,31,32)
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n/an/a 1.10n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP2 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50350604
PNG
(CHEMBL1812922)
Show SMILES O=C1NC(=O)C(N2CCCN(CC3CC3)CC2)(C(=O)N1)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C25H28N4O4/c30-22-25(23(31)27-24(32)26-22,29-14-4-13-28(15-16-29)17-18-7-8-18)19-9-11-21(12-10-19)33-20-5-2-1-3-6-20/h1-3,5-6,9-12,18H,4,7-8,13-17H2,(H2,26,27,30,31,32)
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n/an/a 1.10n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP9 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50350606
PNG
(CHEMBL1812924)
Show SMILES CC(=O)N1CCCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C23H24N4O5/c1-16(28)26-12-5-13-27(15-14-26)23(20(29)24-22(31)25-21(23)30)17-8-10-19(11-9-17)32-18-6-3-2-4-7-18/h2-4,6-11H,5,12-15H2,1H3,(H2,24,25,29,30,31)
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n/an/a 1.5n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP9 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50350607
PNG
(CHEMBL1812925)
Show SMILES CN1CCCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C22H24N4O4/c1-25-12-5-13-26(15-14-25)22(19(27)23-21(29)24-20(22)28)16-8-10-18(11-9-16)30-17-6-3-2-4-7-17/h2-4,6-11H,5,12-15H2,1H3,(H2,23,24,27,28,29)
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n/an/a 1.90n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP9 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
72 kDa type IV collagenase


(Homo sapiens (Human))		BDBM50350623
PNG
(CHEMBL1812941)
Show SMILES Cc1c(oc2ccccc12)C(=O)N1CCCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C31H28N4O6/c1-20-24-10-5-6-11-25(24)41-26(20)27(36)34-16-7-17-35(19-18-34)31(28(37)32-30(39)33-29(31)38)21-12-14-23(15-13-21)40-22-8-3-2-4-9-22/h2-6,8-15H,7,16-19H2,1H3,(H2,32,33,37,38,39)
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n/an/a 2.60n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP2 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50350623
PNG
(CHEMBL1812941)
Show SMILES Cc1c(oc2ccccc12)C(=O)N1CCCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C31H28N4O6/c1-20-24-10-5-6-11-25(24)41-26(20)27(36)34-16-7-17-35(19-18-34)31(28(37)32-30(39)33-29(31)38)21-12-14-23(15-13-21)40-22-8-3-2-4-9-22/h2-6,8-15H,7,16-19H2,1H3,(H2,32,33,37,38,39)
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n/an/a 2.90n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP9 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
72 kDa type IV collagenase


(Homo sapiens (Human))		BDBM50350606
PNG
(CHEMBL1812924)
Show SMILES CC(=O)N1CCCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C23H24N4O5/c1-16(28)26-12-5-13-27(15-14-26)23(20(29)24-22(31)25-21(23)30)17-8-10-19(11-9-17)32-18-6-3-2-4-7-18/h2-4,6-11H,5,12-15H2,1H3,(H2,24,25,29,30,31)
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n/an/a 2.90n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP2 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50350599
PNG
(CHEMBL1812914)
Show SMILES O=C1NC(=O)C(N2CCN(CC3CC3)CC2)(C(=O)N1)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C24H26N4O4/c29-21-24(22(30)26-23(31)25-21,28-14-12-27(13-15-28)16-17-6-7-17)18-8-10-20(11-9-18)32-19-4-2-1-3-5-19/h1-5,8-11,17H,6-7,12-16H2,(H2,25,26,29,30,31)
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n/an/a 5.20n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP9 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
72 kDa type IV collagenase


(Homo sapiens (Human))		BDBM50350607
PNG
(CHEMBL1812925)
Show SMILES CN1CCCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C22H24N4O4/c1-25-12-5-13-26(15-14-25)22(19(27)23-21(29)24-20(22)28)16-8-10-18(11-9-16)30-17-6-3-2-4-7-17/h2-4,6-11H,5,12-15H2,1H3,(H2,23,24,27,28,29)
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n/an/a 7.5n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP2 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
72 kDa type IV collagenase


(Homo sapiens (Human))		BDBM50350603
PNG
(CHEMBL1812921)
Show SMILES CN1CCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C21H22N4O4/c1-24-11-13-25(14-12-24)21(18(26)22-20(28)23-19(21)27)15-7-9-17(10-8-15)29-16-5-3-2-4-6-16/h2-10H,11-14H2,1H3,(H2,22,23,26,27,28)
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n/an/a 9.40n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP2 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
72 kDa type IV collagenase


(Homo sapiens (Human))		BDBM50350613
PNG
(CHEMBL1812931)
Show SMILES O=C(N1CCCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1)c1ccc(cc1)C#N
Show InChI InChI=1S/C29H25N5O5/c30-19-20-7-9-21(10-8-20)25(35)33-15-4-16-34(18-17-33)29(26(36)31-28(38)32-27(29)37)22-11-13-24(14-12-22)39-23-5-2-1-3-6-23/h1-3,5-14H,4,15-18H2,(H2,31,32,36,37,38)
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n/an/a 9.80n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP2 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
72 kDa type IV collagenase


(Homo sapiens (Human))		BDBM50350599
PNG
(CHEMBL1812914)
Show SMILES O=C1NC(=O)C(N2CCN(CC3CC3)CC2)(C(=O)N1)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C24H26N4O4/c29-21-24(22(30)26-23(31)25-21,28-14-12-27(13-15-28)16-17-6-7-17)18-8-10-20(11-9-18)32-19-4-2-1-3-5-19/h1-5,8-11,17H,6-7,12-16H2,(H2,25,26,29,30,31)
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n/an/a 10n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP2 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
72 kDa type IV collagenase


(Homo sapiens (Human))		BDBM50350611
PNG
(CHEMBL1812929)
Show SMILES O=C(C1CC1)N1CCCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C25H26N4O5/c30-21(17-7-8-17)28-13-4-14-29(16-15-28)25(22(31)26-24(33)27-23(25)32)18-9-11-20(12-10-18)34-19-5-2-1-3-6-19/h1-3,5-6,9-12,17H,4,7-8,13-16H2,(H2,26,27,31,32,33)
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n/an/a 13n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP2 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
72 kDa type IV collagenase


(Homo sapiens (Human))		BDBM50350615
PNG
(CHEMBL1812933)
Show SMILES O=C(C1CCC1)N1CCCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C26H28N4O5/c31-22(18-6-4-7-18)29-14-5-15-30(17-16-29)26(23(32)27-25(34)28-24(26)33)19-10-12-21(13-11-19)35-20-8-2-1-3-9-20/h1-3,8-13,18H,4-7,14-17H2,(H2,27,28,32,33,34)
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n/an/a 13n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP2 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50350611
PNG
(CHEMBL1812929)
Show SMILES O=C(C1CC1)N1CCCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C25H26N4O5/c30-21(17-7-8-17)28-13-4-14-29(16-15-28)25(22(31)26-24(33)27-23(25)32)18-9-11-20(12-10-18)34-19-5-2-1-3-6-19/h1-3,5-6,9-12,17H,4,7-8,13-16H2,(H2,26,27,31,32,33)
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n/an/a 13n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP9 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50350602
PNG
(CHEMBL1812920)
Show SMILES CC(=O)N1CCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C22H22N4O5/c1-15(27)25-11-13-26(14-12-25)22(19(28)23-21(30)24-20(22)29)16-7-9-18(10-8-16)31-17-5-3-2-4-6-17/h2-10H,11-14H2,1H3,(H2,23,24,28,29,30)
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n/an/a 14n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP9 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50350615
PNG
(CHEMBL1812933)
Show SMILES O=C(C1CCC1)N1CCCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C26H28N4O5/c31-22(18-6-4-7-18)29-14-5-15-30(17-16-29)26(23(32)27-25(34)28-24(26)33)19-10-12-21(13-11-19)35-20-8-2-1-3-9-20/h1-3,8-13,18H,4-7,14-17H2,(H2,27,28,32,33,34)
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n/an/a 14n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP9 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
72 kDa type IV collagenase


(Homo sapiens (Human))		BDBM50350600
PNG
(CHEMBL1812915)
Show SMILES O=C(C1CC1)N1CCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C24H24N4O5/c29-20(16-6-7-16)27-12-14-28(15-13-27)24(21(30)25-23(32)26-22(24)31)17-8-10-19(11-9-17)33-18-4-2-1-3-5-18/h1-5,8-11,16H,6-7,12-15H2,(H2,25,26,30,31,32)
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n/an/a 15n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP2 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50350594
PNG
(CHEMBL1812961)
Show SMILES Cc1cc(NS(=O)(=O)c2cccc(c2)C(=O)N2CCCN(CC2)C2(C(=O)NC(=O)NC2=O)c2ccc(Oc3ccccc3)cc2)no1
Show InChI InChI=1S/C32H30N6O8S/c1-21-19-27(35-46-21)36-47(43,44)26-10-5-7-22(20-26)28(39)37-15-6-16-38(18-17-37)32(29(40)33-31(42)34-30(32)41)23-11-13-25(14-12-23)45-24-8-3-2-4-9-24/h2-5,7-14,19-20H,6,15-18H2,1H3,(H,35,36)(H2,33,34,40,41,42)
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n/an/a 15n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP9 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
72 kDa type IV collagenase


(Homo sapiens (Human))		BDBM50350602
PNG
(CHEMBL1812920)
Show SMILES CC(=O)N1CCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C22H22N4O5/c1-15(27)25-11-13-26(14-12-25)22(19(28)23-21(30)24-20(22)29)16-7-9-18(10-8-16)31-17-5-3-2-4-6-17/h2-10H,11-14H2,1H3,(H2,23,24,28,29,30)
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n/an/a 16n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP2 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
72 kDa type IV collagenase


(Homo sapiens (Human))		BDBM50350612
PNG
(CHEMBL1812930)
Show SMILES O=C(N1CCCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1)c1cccs1
Show InChI InChI=1S/C26H24N4O5S/c31-22(21-8-4-17-36-21)29-13-5-14-30(16-15-29)26(23(32)27-25(34)28-24(26)33)18-9-11-20(12-10-18)35-19-6-2-1-3-7-19/h1-4,6-12,17H,5,13-16H2,(H2,27,28,32,33,34)
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n/an/a 16n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP2 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50350603
PNG
(CHEMBL1812921)
Show SMILES CN1CCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C21H22N4O4/c1-24-11-13-25(14-12-24)21(18(26)22-20(28)23-19(21)27)15-7-9-17(10-8-15)29-16-5-3-2-4-6-16/h2-10H,11-14H2,1H3,(H2,22,23,26,27,28)
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n/an/a 16n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP9 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50350612
PNG
(CHEMBL1812930)
Show SMILES O=C(N1CCCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1)c1cccs1
Show InChI InChI=1S/C26H24N4O5S/c31-22(21-8-4-17-36-21)29-13-5-14-30(16-15-29)26(23(32)27-25(34)28-24(26)33)18-9-11-20(12-10-18)35-19-6-2-1-3-7-19/h1-4,6-12,17H,5,13-16H2,(H2,27,28,32,33,34)
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n/an/a 19n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP9 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
72 kDa type IV collagenase


(Homo sapiens (Human))		BDBM50350594
PNG
(CHEMBL1812961)
Show SMILES Cc1cc(NS(=O)(=O)c2cccc(c2)C(=O)N2CCCN(CC2)C2(C(=O)NC(=O)NC2=O)c2ccc(Oc3ccccc3)cc2)no1
Show InChI InChI=1S/C32H30N6O8S/c1-21-19-27(35-46-21)36-47(43,44)26-10-5-7-22(20-26)28(39)37-15-6-16-38(18-17-37)32(29(40)33-31(42)34-30(32)41)23-11-13-25(14-12-23)45-24-8-3-2-4-9-24/h2-5,7-14,19-20H,6,15-18H2,1H3,(H,35,36)(H2,33,34,40,41,42)
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n/an/a 20n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP2 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
72 kDa type IV collagenase


(Homo sapiens (Human))		BDBM50350605
PNG
(CHEMBL1812923)
Show SMILES O=C1NC(=O)C(N2CCCN(Cc3ccccc3)CC2)(C(=O)N1)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C28H28N4O4/c33-25-28(26(34)30-27(35)29-25,22-12-14-24(15-13-22)36-23-10-5-2-6-11-23)32-17-7-16-31(18-19-32)20-21-8-3-1-4-9-21/h1-6,8-15H,7,16-20H2,(H2,29,30,33,34,35)
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n/an/a 22n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP2 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
72 kDa type IV collagenase


(Homo sapiens (Human))		BDBM50350632
PNG
(CHEMBL1812950)
Show SMILES Clc1cccc(Cl)c1C(=O)N1CCCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C28H24Cl2N4O5/c29-21-8-4-9-22(30)23(21)24(35)33-14-5-15-34(17-16-33)28(25(36)31-27(38)32-26(28)37)18-10-12-20(13-11-18)39-19-6-2-1-3-7-19/h1-4,6-13H,5,14-17H2,(H2,31,32,36,37,38)
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n/an/a 23n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP2 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
72 kDa type IV collagenase


(Homo sapiens (Human))		BDBM50350591
PNG
(CHEMBL1812958)
Show SMILES Cn1nc(C(=O)N2CCCN(CC2)C2(C(=O)NC(=O)NC2=O)c2ccc(Oc3ccccc3)cc2)c2ccccc12
Show InChI InChI=1S/C30H28N6O5/c1-34-24-11-6-5-10-23(24)25(33-34)26(37)35-16-7-17-36(19-18-35)30(27(38)31-29(40)32-28(30)39)20-12-14-22(15-13-20)41-21-8-3-2-4-9-21/h2-6,8-15H,7,16-19H2,1H3,(H2,31,32,38,39,40)
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n/an/a 24n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP2 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
72 kDa type IV collagenase


(Homo sapiens (Human))		BDBM50350625
PNG
(CHEMBL1812943)
Show SMILES Cc1cc(C(=O)N2CCCN(CC2)C2(C(=O)NC(=O)NC2=O)c2ccc(Oc3ccccc3)cc2)c(C)o1
Show InChI InChI=1S/C28H28N4O6/c1-18-17-23(19(2)37-18)24(33)31-13-6-14-32(16-15-31)28(25(34)29-27(36)30-26(28)35)20-9-11-22(12-10-20)38-21-7-4-3-5-8-21/h3-5,7-12,17H,6,13-16H2,1-2H3,(H2,29,30,34,35,36)
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n/an/a 24n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP2 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50350588
PNG
(CHEMBL1812955)
Show SMILES O=C(N1CCOCC1)N1CCCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C26H29N5O6/c32-22-26(23(33)28-24(34)27-22,19-7-9-21(10-8-19)37-20-5-2-1-3-6-20)31-12-4-11-29(13-14-31)25(35)30-15-17-36-18-16-30/h1-3,5-10H,4,11-18H2,(H2,27,28,32,33,34)
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n/an/a 24n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP9 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
72 kDa type IV collagenase


(Homo sapiens (Human))		BDBM50350588
PNG
(CHEMBL1812955)
Show SMILES O=C(N1CCOCC1)N1CCCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C26H29N5O6/c32-22-26(23(33)28-24(34)27-22,19-7-9-21(10-8-19)37-20-5-2-1-3-6-20)31-12-4-11-29(13-14-31)25(35)30-15-17-36-18-16-30/h1-3,5-10H,4,11-18H2,(H2,27,28,32,33,34)
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n/an/a 25n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP2 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50350625
PNG
(CHEMBL1812943)
Show SMILES Cc1cc(C(=O)N2CCCN(CC2)C2(C(=O)NC(=O)NC2=O)c2ccc(Oc3ccccc3)cc2)c(C)o1
Show InChI InChI=1S/C28H28N4O6/c1-18-17-23(19(2)37-18)24(33)31-13-6-14-32(16-15-31)28(25(34)29-27(36)30-26(28)35)20-9-11-22(12-10-20)38-21-7-4-3-5-8-21/h3-5,7-12,17H,6,13-16H2,1-2H3,(H2,29,30,34,35,36)
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n/an/a 25n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP9 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
72 kDa type IV collagenase


(Homo sapiens (Human))		BDBM50350587
PNG
(CHEMBL1812954)
Show SMILES Fc1cc(C(=O)N2CCCN(CC2)C2(C(=O)NC(=O)NC2=O)c2ccc(Oc3ccccc3)cc2)c(Cl)nc1Cl
Show InChI InChI=1S/C27H22Cl2FN5O5/c28-21-19(15-20(30)22(29)31-21)23(36)34-11-4-12-35(14-13-34)27(24(37)32-26(39)33-25(27)38)16-7-9-18(10-8-16)40-17-5-2-1-3-6-17/h1-3,5-10,15H,4,11-14H2,(H2,32,33,37,38,39)
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n/an/a 25n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP2 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50350605
PNG
(CHEMBL1812923)
Show SMILES O=C1NC(=O)C(N2CCCN(Cc3ccccc3)CC2)(C(=O)N1)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C28H28N4O4/c33-25-28(26(34)30-27(35)29-25,22-12-14-24(15-13-22)36-23-10-5-2-6-11-23)32-17-7-16-31(18-19-32)20-21-8-3-1-4-9-21/h1-6,8-15H,7,16-20H2,(H2,29,30,33,34,35)
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n/an/a 26n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP9 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50350600
PNG
(CHEMBL1812915)
Show SMILES O=C(C1CC1)N1CCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C24H24N4O5/c29-20(16-6-7-16)27-12-14-28(15-13-27)24(21(30)25-23(32)26-22(24)31)17-8-10-19(11-9-17)33-18-4-2-1-3-5-18/h1-5,8-11,16H,6-7,12-15H2,(H2,25,26,30,31,32)
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n/an/a 27n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP9 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50350613
PNG
(CHEMBL1812931)
Show SMILES O=C(N1CCCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1)c1ccc(cc1)C#N
Show InChI InChI=1S/C29H25N5O5/c30-19-20-7-9-21(10-8-20)25(35)33-15-4-16-34(18-17-33)29(26(36)31-28(38)32-27(29)37)22-11-13-24(14-12-22)39-23-5-2-1-3-6-23/h1-3,5-14H,4,15-18H2,(H2,31,32,36,37,38)
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n/an/a 28n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP9 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50350621
PNG
(CHEMBL1812939)
Show SMILES Cc1cc(cc(Cl)n1)C(=O)N1CCCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C28H26ClN5O5/c1-18-16-19(17-23(29)30-18)24(35)33-12-5-13-34(15-14-33)28(25(36)31-27(38)32-26(28)37)20-8-10-22(11-9-20)39-21-6-3-2-4-7-21/h2-4,6-11,16-17H,5,12-15H2,1H3,(H2,31,32,36,37,38)
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n/an/a 28n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP9 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50350596
PNG
(CHEMBL1812963)
Show SMILES COc1ccc(NS(=O)(=O)c2cc(ccc2C)C(=O)N2CCCN(CC2)C2(C(=O)NC(=O)NC2=O)c2ccc(Oc3ccccc3)cc2)cc1
Show InChI InChI=1S/C36H35N5O8S/c1-24-9-10-25(23-31(24)50(46,47)39-27-13-17-28(48-2)18-14-27)32(42)40-19-6-20-41(22-21-40)36(33(43)37-35(45)38-34(36)44)26-11-15-30(16-12-26)49-29-7-4-3-5-8-29/h3-5,7-18,23,39H,6,19-22H2,1-2H3,(H2,37,38,43,44,45)
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n/an/a 28n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP9 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
72 kDa type IV collagenase


(Homo sapiens (Human))		BDBM50350616
PNG
(CHEMBL1812934)
Show SMILES O=C(CSc1ccccc1)N1CCCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C29H28N4O5S/c34-25(20-39-24-10-5-2-6-11-24)32-16-7-17-33(19-18-32)29(26(35)30-28(37)31-27(29)36)21-12-14-23(15-13-21)38-22-8-3-1-4-9-22/h1-6,8-15H,7,16-20H2,(H2,30,31,35,36,37)
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n/an/a 29n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP2 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
72 kDa type IV collagenase


(Homo sapiens (Human))		BDBM50350626
PNG
(CHEMBL1812944)
Show SMILES O=C(N1CCCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1)c1cnc2ccccc2n1
Show InChI InChI=1S/C30H26N6O5/c37-26(25-19-31-23-9-4-5-10-24(23)32-25)35-15-6-16-36(18-17-35)30(27(38)33-29(40)34-28(30)39)20-11-13-22(14-12-20)41-21-7-2-1-3-8-21/h1-5,7-14,19H,6,15-18H2,(H2,33,34,38,39,40)
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n/an/a 30n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP2 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
72 kDa type IV collagenase


(Homo sapiens (Human))		BDBM50350633
PNG
(CHEMBL1812951)
Show SMILES O=C(CCc1ccccc1)N1CCCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C30H30N4O5/c35-26(17-12-22-8-3-1-4-9-22)33-18-7-19-34(21-20-33)30(27(36)31-29(38)32-28(30)37)23-13-15-25(16-14-23)39-24-10-5-2-6-11-24/h1-6,8-11,13-16H,7,12,17-21H2,(H2,31,32,36,37,38)
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n/an/a 31n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP2 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50350626
PNG
(CHEMBL1812944)
Show SMILES O=C(N1CCCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1)c1cnc2ccccc2n1
Show InChI InChI=1S/C30H26N6O5/c37-26(25-19-31-23-9-4-5-10-24(23)32-25)35-15-6-16-36(18-17-35)30(27(38)33-29(40)34-28(30)39)20-11-13-22(14-12-20)41-21-7-2-1-3-8-21/h1-5,7-14,19H,6,15-18H2,(H2,33,34,38,39,40)
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n/an/a 34n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP9 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50350616
PNG
(CHEMBL1812934)
Show SMILES O=C(CSc1ccccc1)N1CCCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C29H28N4O5S/c34-25(20-39-24-10-5-2-6-11-24)32-16-7-17-33(19-18-32)29(26(35)30-28(37)31-27(29)36)21-12-14-23(15-13-21)38-22-8-3-1-4-9-22/h1-6,8-15H,7,16-20H2,(H2,30,31,35,36,37)
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n/an/a 36n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP9 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50350608
PNG
(CHEMBL1812926)
Show SMILES O=C(N1CCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1)c1cccs1
Show InChI InChI=1S/C25H22N4O5S/c30-21(20-7-4-16-35-20)28-12-14-29(15-13-28)25(22(31)26-24(33)27-23(25)32)17-8-10-19(11-9-17)34-18-5-2-1-3-6-18/h1-11,16H,12-15H2,(H2,26,27,31,32,33)
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n/an/a 43n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP9 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50350609
PNG
(CHEMBL1812927)
Show SMILES O=C(N1CCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1)c1ccc(cc1)C#N
Show InChI InChI=1S/C28H23N5O5/c29-18-19-6-8-20(9-7-19)24(34)32-14-16-33(17-15-32)28(25(35)30-27(37)31-26(28)36)21-10-12-23(13-11-21)38-22-4-2-1-3-5-22/h1-13H,14-17H2,(H2,30,31,35,36,37)
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n/an/a 43n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP9 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50350630
PNG
(CHEMBL1812948)
Show SMILES Cc1ccc(cc1)C(=O)N1CCCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C29H28N4O5/c1-20-8-10-21(11-9-20)25(34)32-16-5-17-33(19-18-32)29(26(35)30-28(37)31-27(29)36)22-12-14-24(15-13-22)38-23-6-3-2-4-7-23/h2-4,6-15H,5,16-19H2,1H3,(H2,30,31,35,36,37)
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n/an/a 44n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP9 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
72 kDa type IV collagenase


(Homo sapiens (Human))		BDBM50350609
PNG
(CHEMBL1812927)
Show SMILES O=C(N1CCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1)c1ccc(cc1)C#N
Show InChI InChI=1S/C28H23N5O5/c29-18-19-6-8-20(9-7-19)24(34)32-14-16-33(17-15-32)28(25(35)30-27(37)31-26(28)36)21-10-12-23(13-11-21)38-22-4-2-1-3-5-22/h1-13H,14-17H2,(H2,30,31,35,36,37)
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n/an/a 45n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP2 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50350610
PNG
(CHEMBL1812928)
Show SMILES Clc1ccc(cn1)C(=O)N1CCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C26H22ClN5O5/c27-21-11-6-17(16-28-21)22(33)31-12-14-32(15-13-31)26(23(34)29-25(36)30-24(26)35)18-7-9-20(10-8-18)37-19-4-2-1-3-5-19/h1-11,16H,12-15H2,(H2,29,30,34,35,36)
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n/an/a 45n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP9 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
72 kDa type IV collagenase


(Homo sapiens (Human))		BDBM50350627
PNG
(CHEMBL1812945)
Show SMILES O=C(Cc1cccs1)N1CCCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C27H26N4O5S/c32-23(18-22-8-4-17-37-22)30-13-5-14-31(16-15-30)27(24(33)28-26(35)29-25(27)34)19-9-11-21(12-10-19)36-20-6-2-1-3-7-20/h1-4,6-12,17H,5,13-16,18H2,(H2,28,29,33,34,35)
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n/an/a 47n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP2 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
72 kDa type IV collagenase


(Homo sapiens (Human))		BDBM50350619
PNG
(CHEMBL1812937)
Show SMILES O=C(CCC1CCCC1)N1CCCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C29H34N4O5/c34-25(16-11-21-7-4-5-8-21)32-17-6-18-33(20-19-32)29(26(35)30-28(37)31-27(29)36)22-12-14-24(15-13-22)38-23-9-2-1-3-10-23/h1-3,9-10,12-15,21H,4-8,11,16-20H2,(H2,30,31,35,36,37)
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n/an/a 50n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP2 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50350627
PNG
(CHEMBL1812945)
Show SMILES O=C(Cc1cccs1)N1CCCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C27H26N4O5S/c32-23(18-22-8-4-17-37-22)30-13-5-14-31(16-15-30)27(24(33)28-26(35)29-25(27)34)19-9-11-21(12-10-19)36-20-6-2-1-3-7-20/h1-4,6-12,17H,5,13-16,18H2,(H2,28,29,33,34,35)
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n/an/a 51n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP9 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
72 kDa type IV collagenase


(Homo sapiens (Human))		BDBM50350610
PNG
(CHEMBL1812928)
Show SMILES Clc1ccc(cn1)C(=O)N1CCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C26H22ClN5O5/c27-21-11-6-17(16-28-21)22(33)31-12-14-32(15-13-31)26(23(34)29-25(36)30-24(26)35)18-7-9-20(10-8-18)37-19-4-2-1-3-5-19/h1-11,16H,12-15H2,(H2,29,30,34,35,36)
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n/an/a 54n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP2 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
72 kDa type IV collagenase


(Homo sapiens (Human))		BDBM50350596
PNG
(CHEMBL1812963)
Show SMILES COc1ccc(NS(=O)(=O)c2cc(ccc2C)C(=O)N2CCCN(CC2)C2(C(=O)NC(=O)NC2=O)c2ccc(Oc3ccccc3)cc2)cc1
Show InChI InChI=1S/C36H35N5O8S/c1-24-9-10-25(23-31(24)50(46,47)39-27-13-17-28(48-2)18-14-27)32(42)40-19-6-20-41(22-21-40)36(33(43)37-35(45)38-34(36)44)26-11-15-30(16-12-26)49-29-7-4-3-5-8-29/h3-5,7-18,23,39H,6,19-22H2,1-2H3,(H2,37,38,43,44,45)
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n/an/a 54n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP2 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50350595
PNG
(CHEMBL1812962)
Show SMILES CS(=O)(=O)Nc1ccc(F)cc1C(=O)N1CCCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C29H28FN5O7S/c1-43(40,41)33-24-13-10-20(30)18-23(24)25(36)34-14-5-15-35(17-16-34)29(26(37)31-28(39)32-27(29)38)19-8-11-22(12-9-19)42-21-6-3-2-4-7-21/h2-4,6-13,18,33H,5,14-17H2,1H3,(H2,31,32,37,38,39)
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n/an/a 57n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP9 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
72 kDa type IV collagenase


(Homo sapiens (Human))		BDBM50350618
PNG
(CHEMBL1812936)
Show SMILES FC(F)(F)Oc1ccc(cc1)C(=O)N1CCCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C29H25F3N4O6/c30-29(31,32)42-23-11-7-19(8-12-23)24(37)35-15-4-16-36(18-17-35)28(25(38)33-27(40)34-26(28)39)20-9-13-22(14-10-20)41-21-5-2-1-3-6-21/h1-3,5-14H,4,15-18H2,(H2,33,34,38,39,40)
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n/an/a 60n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP2 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50350633
PNG
(CHEMBL1812951)
Show SMILES O=C(CCc1ccccc1)N1CCCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C30H30N4O5/c35-26(17-12-22-8-3-1-4-9-22)33-18-7-19-34(21-20-33)30(27(36)31-29(38)32-28(30)37)23-13-15-25(16-14-23)39-24-10-5-2-6-11-24/h1-6,8-11,13-16H,7,12,17-21H2,(H2,31,32,36,37,38)
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n/an/a 62n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP9 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50350618
PNG
(CHEMBL1812936)
Show SMILES FC(F)(F)Oc1ccc(cc1)C(=O)N1CCCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C29H25F3N4O6/c30-29(31,32)42-23-11-7-19(8-12-23)24(37)35-15-4-16-36(18-17-35)28(25(38)33-27(40)34-26(28)39)20-9-13-22(14-10-20)41-21-5-2-1-3-6-21/h1-3,5-14H,4,15-18H2,(H2,33,34,38,39,40)
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n/an/a 70n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP9 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
72 kDa type IV collagenase


(Homo sapiens (Human))		BDBM50350608
PNG
(CHEMBL1812926)
Show SMILES O=C(N1CCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1)c1cccs1
Show InChI InChI=1S/C25H22N4O5S/c30-21(20-7-4-16-35-20)28-12-14-29(15-13-28)25(22(31)26-24(33)27-23(25)32)17-8-10-19(11-9-17)34-18-5-2-1-3-6-18/h1-11,16H,12-15H2,(H2,26,27,31,32,33)
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n/an/a 73n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP2 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50350589
PNG
(CHEMBL1812956)
Show SMILES CN(C)c1cccc2c(cccc12)S(=O)(=O)N1CCCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C33H33N5O6S/c1-36(2)28-13-6-12-27-26(28)11-7-14-29(27)45(42,43)38-20-8-19-37(21-22-38)33(30(39)34-32(41)35-31(33)40)23-15-17-25(18-16-23)44-24-9-4-3-5-10-24/h3-7,9-18H,8,19-22H2,1-2H3,(H2,34,35,39,40,41)
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n/an/a 74n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP9 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50350598
PNG
(CHEMBL1812965)
Show SMILES Oc1nc(Nc2ccccc2)sc1CC(=O)N1CCCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C32H30N6O6S/c39-26(20-25-27(40)34-31(45-25)33-22-8-3-1-4-9-22)37-16-7-17-38(19-18-37)32(28(41)35-30(43)36-29(32)42)21-12-14-24(15-13-21)44-23-10-5-2-6-11-23/h1-6,8-15,40H,7,16-20H2,(H,33,34)(H2,35,36,41,42,43)
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n/an/a 76n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP9 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50350586
PNG
(CHEMBL1812953)
Show SMILES O=C(CC1CCCCC1)N1CCCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C29H34N4O5/c34-25(20-21-8-3-1-4-9-21)32-16-7-17-33(19-18-32)29(26(35)30-28(37)31-27(29)36)22-12-14-24(15-13-22)38-23-10-5-2-6-11-23/h2,5-6,10-15,21H,1,3-4,7-9,16-20H2,(H2,30,31,35,36,37)
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n/an/a 77n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP9 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50350597
PNG
(CHEMBL1812964)
Show SMILES Cc1ccc(C(=O)N2CCCN(CC2)C2(C(=O)NC(=O)NC2=O)c2ccc(Oc3ccccc3)cc2)c(NS(C)(=O)=O)c1
Show InChI InChI=1S/C30H31N5O7S/c1-20-9-14-24(25(19-20)33-43(2,40)41)26(36)34-15-6-16-35(18-17-34)30(27(37)31-29(39)32-28(30)38)21-10-12-23(13-11-21)42-22-7-4-3-5-8-22/h3-5,7-14,19,33H,6,15-18H2,1-2H3,(H2,31,32,37,38,39)
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n/an/a 80n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP9 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
72 kDa type IV collagenase


(Homo sapiens (Human))		BDBM50350630
PNG
(CHEMBL1812948)
Show SMILES Cc1ccc(cc1)C(=O)N1CCCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C29H28N4O5/c1-20-8-10-21(11-9-20)25(34)32-16-5-17-33(19-18-32)29(26(35)30-28(37)31-27(29)36)22-12-14-24(15-13-22)38-23-6-3-2-4-7-23/h2-4,6-15H,5,16-19H2,1H3,(H2,30,31,35,36,37)
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n/an/a 80n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP2 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50350587
PNG
(CHEMBL1812954)
Show SMILES Fc1cc(C(=O)N2CCCN(CC2)C2(C(=O)NC(=O)NC2=O)c2ccc(Oc3ccccc3)cc2)c(Cl)nc1Cl
Show InChI InChI=1S/C27H22Cl2FN5O5/c28-21-19(15-20(30)22(29)31-21)23(36)34-11-4-12-35(14-13-34)27(24(37)32-26(39)33-25(27)38)16-7-9-18(10-8-16)40-17-5-2-1-3-6-17/h1-3,5-10,15H,4,11-14H2,(H2,32,33,37,38,39)
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n/an/a 81n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP9 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
72 kDa type IV collagenase


(Homo sapiens (Human))		BDBM50350595
PNG
(CHEMBL1812962)
Show SMILES CS(=O)(=O)Nc1ccc(F)cc1C(=O)N1CCCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C29H28FN5O7S/c1-43(40,41)33-24-13-10-20(30)18-23(24)25(36)34-14-5-15-35(17-16-34)29(26(37)31-28(39)32-27(29)38)19-8-11-22(12-9-19)42-21-6-3-2-4-7-21/h2-4,6-13,18,33H,5,14-17H2,1H3,(H2,31,32,37,38,39)
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n/an/a 83n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP2 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
72 kDa type IV collagenase


(Homo sapiens (Human))		BDBM50350601
PNG
(CHEMBL1812918)
Show SMILES O=C1NC(=O)C(N2CCN(Cc3ccccc3)CC2)(C(=O)N1)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C27H26N4O4/c32-24-27(25(33)29-26(34)28-24,21-11-13-23(14-12-21)35-22-9-5-2-6-10-22)31-17-15-30(16-18-31)19-20-7-3-1-4-8-20/h1-14H,15-19H2,(H2,28,29,32,33,34)
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n/an/a 86n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP2 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
72 kDa type IV collagenase


(Homo sapiens (Human))		BDBM50350621
PNG
(CHEMBL1812939)
Show SMILES Cc1cc(cc(Cl)n1)C(=O)N1CCCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C28H26ClN5O5/c1-18-16-19(17-23(29)30-18)24(35)33-12-5-13-34(15-14-33)28(25(36)31-27(38)32-26(28)37)20-8-10-22(11-9-20)39-21-6-3-2-4-7-21/h2-4,6-11,16-17H,5,12-15H2,1H3,(H2,31,32,36,37,38)
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n/an/a 86n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP2 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50350632
PNG
(CHEMBL1812950)
Show SMILES Clc1cccc(Cl)c1C(=O)N1CCCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C28H24Cl2N4O5/c29-21-8-4-9-22(30)23(21)24(35)33-14-5-15-34(17-16-33)28(25(36)31-27(38)32-26(28)37)18-10-12-20(13-11-18)39-19-6-2-1-3-7-19/h1-4,6-13H,5,14-17H2,(H2,31,32,36,37,38)
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n/an/a 87n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP9 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50350590
PNG
(CHEMBL1812957)
Show SMILES CSc1ccc(cc1)C(=O)N1CCCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C29H28N4O5S/c1-39-24-14-8-20(9-15-24)25(34)32-16-5-17-33(19-18-32)29(26(35)30-28(37)31-27(29)36)21-10-12-23(13-11-21)38-22-6-3-2-4-7-22/h2-4,6-15H,5,16-19H2,1H3,(H2,30,31,35,36,37)
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n/an/a 93n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP9 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
72 kDa type IV collagenase


(Homo sapiens (Human))		BDBM50350585
PNG
(CHEMBL1812952)
Show SMILES Clc1ccc(CC(=O)N2CCCN(CC2)C2(C(=O)NC(=O)NC2=O)c2ccc(Oc3ccccc3)cc2)cc1
Show InChI InChI=1S/C29H27ClN4O5/c30-22-11-7-20(8-12-22)19-25(35)33-15-4-16-34(18-17-33)29(26(36)31-28(38)32-27(29)37)21-9-13-24(14-10-21)39-23-5-2-1-3-6-23/h1-3,5-14H,4,15-19H2,(H2,31,32,36,37,38)
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n/an/a 95n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP2 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
72 kDa type IV collagenase


(Homo sapiens (Human))		BDBM50350586
PNG
(CHEMBL1812953)
Show SMILES O=C(CC1CCCCC1)N1CCCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C29H34N4O5/c34-25(20-21-8-3-1-4-9-21)32-16-7-17-33(19-18-32)29(26(35)30-28(37)31-27(29)36)22-12-14-24(15-13-22)38-23-10-5-2-6-11-23/h2,5-6,10-15,21H,1,3-4,7-9,16-20H2,(H2,30,31,35,36,37)
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n/an/a 100n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP2 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
72 kDa type IV collagenase


(Homo sapiens (Human))		BDBM50350614
PNG
(CHEMBL1812932)
Show SMILES Clc1ccc(cn1)C(=O)N1CCCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C27H24ClN5O5/c28-22-12-7-18(17-29-22)23(34)32-13-4-14-33(16-15-32)27(24(35)30-26(37)31-25(27)36)19-8-10-21(11-9-19)38-20-5-2-1-3-6-20/h1-3,5-12,17H,4,13-16H2,(H2,30,31,35,36,37)
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n/an/a 104n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP2 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
72 kDa type IV collagenase


(Homo sapiens (Human))		BDBM50350628
PNG
(CHEMBL1812946)
Show SMILES O=C(OCc1ccccc1C(=O)N1CCCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1)c1ccccc1
Show InChI InChI=1S/C36H32N4O7/c41-31(30-15-8-7-12-26(30)24-46-32(42)25-10-3-1-4-11-25)39-20-9-21-40(23-22-39)36(33(43)37-35(45)38-34(36)44)27-16-18-29(19-17-27)47-28-13-5-2-6-14-28/h1-8,10-19H,9,20-24H2,(H2,37,38,43,44,45)
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n/an/a 106n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP2 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50350614
PNG
(CHEMBL1812932)
Show SMILES Clc1ccc(cn1)C(=O)N1CCCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C27H24ClN5O5/c28-22-12-7-18(17-29-22)23(34)32-13-4-14-33(16-15-32)27(24(35)30-26(37)31-25(27)36)19-8-10-21(11-9-19)38-20-5-2-1-3-6-20/h1-3,5-12,17H,4,13-16H2,(H2,30,31,35,36,37)
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n/an/a 110n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP9 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50350628
PNG
(CHEMBL1812946)
Show SMILES O=C(OCc1ccccc1C(=O)N1CCCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1)c1ccccc1
Show InChI InChI=1S/C36H32N4O7/c41-31(30-15-8-7-12-26(30)24-46-32(42)25-10-3-1-4-11-25)39-20-9-21-40(23-22-39)36(33(43)37-35(45)38-34(36)44)27-16-18-29(19-17-27)47-28-13-5-2-6-14-28/h1-8,10-19H,9,20-24H2,(H2,37,38,43,44,45)
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n/an/a 120n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP9 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50350601
PNG
(CHEMBL1812918)
Show SMILES O=C1NC(=O)C(N2CCN(Cc3ccccc3)CC2)(C(=O)N1)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C27H26N4O4/c32-24-27(25(33)29-26(34)28-24,21-11-13-23(14-12-21)35-22-9-5-2-6-10-22)31-17-15-30(16-18-31)19-20-7-3-1-4-8-20/h1-14H,15-19H2,(H2,28,29,32,33,34)
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n/an/a 131n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP9 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
72 kDa type IV collagenase


(Homo sapiens (Human))		BDBM50350597
PNG
(CHEMBL1812964)
Show SMILES Cc1ccc(C(=O)N2CCCN(CC2)C2(C(=O)NC(=O)NC2=O)c2ccc(Oc3ccccc3)cc2)c(NS(C)(=O)=O)c1
Show InChI InChI=1S/C30H31N5O7S/c1-20-9-14-24(25(19-20)33-43(2,40)41)26(36)34-15-6-16-35(18-17-34)30(27(37)31-29(39)32-28(30)38)21-10-12-23(13-11-21)42-22-7-4-3-5-8-22/h3-5,7-14,19,33H,6,15-18H2,1-2H3,(H2,31,32,37,38,39)
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n/an/a 142n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP2 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50350619
PNG
(CHEMBL1812937)
Show SMILES O=C(CCC1CCCC1)N1CCCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C29H34N4O5/c34-25(16-11-21-7-4-5-8-21)32-17-6-18-33(20-19-32)29(26(35)30-28(37)31-27(29)36)22-12-14-24(15-13-22)38-23-9-2-1-3-10-23/h1-3,9-10,12-15,21H,4-8,11,16-20H2,(H2,30,31,35,36,37)
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n/an/a 155n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP9 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50350585
PNG
(CHEMBL1812952)
Show SMILES Clc1ccc(CC(=O)N2CCCN(CC2)C2(C(=O)NC(=O)NC2=O)c2ccc(Oc3ccccc3)cc2)cc1
Show InChI InChI=1S/C29H27ClN4O5/c30-22-11-7-20(8-12-22)19-25(35)33-15-4-16-34(18-17-33)29(26(36)31-28(38)32-27(29)37)21-9-13-24(14-10-21)39-23-5-2-1-3-6-23/h1-3,5-14H,4,15-19H2,(H2,31,32,36,37,38)
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n/an/a 173n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP9 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
72 kDa type IV collagenase


(Homo sapiens (Human))		BDBM50350598
PNG
(CHEMBL1812965)
Show SMILES Oc1nc(Nc2ccccc2)sc1CC(=O)N1CCCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C32H30N6O6S/c39-26(20-25-27(40)34-31(45-25)33-22-8-3-1-4-9-22)37-16-7-17-38(19-18-37)32(28(41)35-30(43)36-29(32)42)21-12-14-24(15-13-21)44-23-10-5-2-6-11-23/h1-6,8-15,40H,7,16-20H2,(H,33,34)(H2,35,36,41,42,43)
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n/an/a 184n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP2 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50350622
PNG
(CHEMBL1812940)
Show SMILES O=C(N1CCNC1=O)N1CCCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C25H26N6O6/c32-20-25(21(33)28-22(34)27-20,17-7-9-19(10-8-17)37-18-5-2-1-3-6-18)30-13-4-12-29(15-16-30)24(36)31-14-11-26-23(31)35/h1-3,5-10H,4,11-16H2,(H,26,35)(H2,27,28,32,33,34)
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n/an/a 191n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP9 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50350629
PNG
(CHEMBL1812947)
Show SMILES FC(F)(F)c1ccc(cn1)C(=O)N1CCCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C28H24F3N5O5/c29-28(30,31)22-12-7-18(17-32-22)23(37)35-13-4-14-36(16-15-35)27(24(38)33-26(40)34-25(27)39)19-8-10-21(11-9-19)41-20-5-2-1-3-6-20/h1-3,5-12,17H,4,13-16H2,(H2,33,34,38,39,40)
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n/an/a 198n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP9 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50350591
PNG
(CHEMBL1812958)
Show SMILES Cn1nc(C(=O)N2CCCN(CC2)C2(C(=O)NC(=O)NC2=O)c2ccc(Oc3ccccc3)cc2)c2ccccc12
Show InChI InChI=1S/C30H28N6O5/c1-34-24-11-6-5-10-23(24)25(33-34)26(37)35-16-7-17-36(19-18-35)30(27(38)31-29(40)32-28(30)39)20-12-14-22(15-13-20)41-21-8-3-2-4-9-21/h2-6,8-15H,7,16-19H2,1H3,(H2,31,32,38,39,40)
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Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP9 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50350624
PNG
(CHEMBL1812942)
Show SMILES Fc1ccc2c(Cl)c(sc2c1)C(=O)N1CCCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C30H24ClFN4O5S/c31-24-22-12-9-19(32)17-23(22)42-25(24)26(37)35-13-4-14-36(16-15-35)30(27(38)33-29(40)34-28(30)39)18-7-10-21(11-8-18)41-20-5-2-1-3-6-20/h1-3,5-12,17H,4,13-16H2,(H2,33,34,38,39,40)
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n/an/a 215n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP9 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
72 kDa type IV collagenase


(Homo sapiens (Human))		BDBM50350629
PNG
(CHEMBL1812947)
Show SMILES FC(F)(F)c1ccc(cn1)C(=O)N1CCCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C28H24F3N5O5/c29-28(30,31)22-12-7-18(17-32-22)23(37)35-13-4-14-36(16-15-35)27(24(38)33-26(40)34-25(27)39)19-8-10-21(11-9-19)41-20-5-2-1-3-6-20/h1-3,5-12,17H,4,13-16H2,(H2,33,34,38,39,40)
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n/an/a 264n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP2 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
72 kDa type IV collagenase


(Homo sapiens (Human))		BDBM50350622
PNG
(CHEMBL1812940)
Show SMILES O=C(N1CCNC1=O)N1CCCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C25H26N6O6/c32-20-25(21(33)28-22(34)27-20,17-7-9-19(10-8-17)37-18-5-2-1-3-6-18)30-13-4-12-29(15-16-30)24(36)31-14-11-26-23(31)35/h1-3,5-10H,4,11-16H2,(H,26,35)(H2,27,28,32,33,34)
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n/an/a 264n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP2 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
72 kDa type IV collagenase


(Homo sapiens (Human))		BDBM50350631
PNG
(CHEMBL1812949)
Show SMILES Brc1ccc(cc1)C(=O)N1CCCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C28H25BrN4O5/c29-21-11-7-19(8-12-21)24(34)32-15-4-16-33(18-17-32)28(25(35)30-27(37)31-26(28)36)20-9-13-23(14-10-20)38-22-5-2-1-3-6-22/h1-3,5-14H,4,15-18H2,(H2,30,31,35,36,37)
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n/an/a 268n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP2 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
72 kDa type IV collagenase


(Homo sapiens (Human))		BDBM50350617
PNG
(CHEMBL1812935)
Show SMILES CCOc1cc(OCC)cc(c1)C(=O)N1CCCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C32H34N4O7/c1-3-41-26-19-22(20-27(21-26)42-4-2)28(37)35-15-8-16-36(18-17-35)32(29(38)33-31(40)34-30(32)39)23-11-13-25(14-12-23)43-24-9-6-5-7-10-24/h5-7,9-14,19-21H,3-4,8,15-18H2,1-2H3,(H2,33,34,38,39,40)
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n/an/a 269n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP2 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50350631
PNG
(CHEMBL1812949)
Show SMILES Brc1ccc(cc1)C(=O)N1CCCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C28H25BrN4O5/c29-21-11-7-19(8-12-21)24(34)32-15-4-16-33(18-17-32)28(25(35)30-27(37)31-26(28)36)20-9-13-23(14-10-20)38-22-5-2-1-3-6-22/h1-3,5-14H,4,15-18H2,(H2,30,31,35,36,37)
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n/an/a 282n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP9 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
72 kDa type IV collagenase


(Homo sapiens (Human))		BDBM50350624
PNG
(CHEMBL1812942)
Show SMILES Fc1ccc2c(Cl)c(sc2c1)C(=O)N1CCCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C30H24ClFN4O5S/c31-24-22-12-9-19(32)17-23(22)42-25(24)26(37)35-13-4-14-36(16-15-35)30(27(38)33-29(40)34-28(30)39)18-7-10-21(11-8-18)41-20-5-2-1-3-6-20/h1-3,5-12,17H,4,13-16H2,(H2,33,34,38,39,40)
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n/an/a 308n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP2 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
72 kDa type IV collagenase


(Homo sapiens (Human))		BDBM50350589
PNG
(CHEMBL1812956)
Show SMILES CN(C)c1cccc2c(cccc12)S(=O)(=O)N1CCCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C33H33N5O6S/c1-36(2)28-13-6-12-27-26(28)11-7-14-29(27)45(42,43)38-20-8-19-37(21-22-38)33(30(39)34-32(41)35-31(33)40)23-15-17-25(18-16-23)44-24-9-4-3-5-10-24/h3-7,9-18H,8,19-22H2,1-2H3,(H2,34,35,39,40,41)
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n/an/a 311n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP2 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
72 kDa type IV collagenase


(Homo sapiens (Human))		BDBM50350620
PNG
(CHEMBL1812938)
Show SMILES CCOc1ccc(OCC)c(c1)C(=O)N1CCCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C32H34N4O7/c1-3-41-25-15-16-27(42-4-2)26(21-25)28(37)35-17-8-18-36(20-19-35)32(29(38)33-31(40)34-30(32)39)22-11-13-24(14-12-22)43-23-9-6-5-7-10-23/h5-7,9-16,21H,3-4,8,17-20H2,1-2H3,(H2,33,34,38,39,40)
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n/an/a 329n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP2 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50350620
PNG
(CHEMBL1812938)
Show SMILES CCOc1ccc(OCC)c(c1)C(=O)N1CCCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C32H34N4O7/c1-3-41-25-15-16-27(42-4-2)26(21-25)28(37)35-17-8-18-36(20-19-35)32(29(38)33-31(40)34-30(32)39)22-11-13-24(14-12-22)43-23-9-6-5-7-10-23/h5-7,9-16,21H,3-4,8,17-20H2,1-2H3,(H2,33,34,38,39,40)
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n/an/a 376n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP9 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
72 kDa type IV collagenase


(Homo sapiens (Human))		BDBM50350590
PNG
(CHEMBL1812957)
Show SMILES CSc1ccc(cc1)C(=O)N1CCCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C29H28N4O5S/c1-39-24-14-8-20(9-15-24)25(34)32-16-5-17-33(19-18-32)29(26(35)30-28(37)31-27(29)36)21-10-12-23(13-11-21)38-22-6-3-2-4-7-22/h2-4,6-15H,5,16-19H2,1H3,(H2,30,31,35,36,37)
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n/an/a 411n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP2 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
72 kDa type IV collagenase


(Homo sapiens (Human))		BDBM50350593
PNG
(CHEMBL1812960)
Show SMILES CC(Cc1nc2ccccc2s1)(C(=O)N1CCCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1)c1ccccc1
Show InChI InChI=1S/C38H35N5O5S/c1-37(26-11-4-2-5-12-26,25-32-39-30-15-8-9-16-31(30)49-32)35(46)42-21-10-22-43(24-23-42)38(33(44)40-36(47)41-34(38)45)27-17-19-29(20-18-27)48-28-13-6-3-7-14-28/h2-9,11-20H,10,21-25H2,1H3,(H2,40,41,44,45,47)
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n/an/a 681n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP2 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50350592
PNG
(CHEMBL1812959)
Show SMILES CC(C)C(NS(=O)(=O)c1ccc2OCCOc2c1)C(=O)N1CCCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C34H37N5O9S/c1-22(2)29(37-49(44,45)26-13-14-27-28(21-26)47-20-19-46-27)30(40)38-15-6-16-39(18-17-38)34(31(41)35-33(43)36-32(34)42)23-9-11-25(12-10-23)48-24-7-4-3-5-8-24/h3-5,7-14,21-22,29,37H,6,15-20H2,1-2H3,(H2,35,36,41,42,43)
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n/an/a 698n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP9 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
72 kDa type IV collagenase


(Homo sapiens (Human))		BDBM50350592
PNG
(CHEMBL1812959)
Show SMILES CC(C)C(NS(=O)(=O)c1ccc2OCCOc2c1)C(=O)N1CCCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C34H37N5O9S/c1-22(2)29(37-49(44,45)26-13-14-27-28(21-26)47-20-19-46-27)30(40)38-15-6-16-39(18-17-38)34(31(41)35-33(43)36-32(34)42)23-9-11-25(12-10-23)48-24-7-4-3-5-8-24/h3-5,7-14,21-22,29,37H,6,15-20H2,1-2H3,(H2,35,36,41,42,43)
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n/an/a 706n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP2 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50350593
PNG
(CHEMBL1812960)
Show SMILES CC(Cc1nc2ccccc2s1)(C(=O)N1CCCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1)c1ccccc1
Show InChI InChI=1S/C38H35N5O5S/c1-37(26-11-4-2-5-12-26,25-32-39-30-15-8-9-16-31(30)49-32)35(46)42-21-10-22-43(24-23-42)38(33(44)40-36(47)41-34(38)45)27-17-19-29(20-18-27)48-28-13-6-3-7-14-28/h2-9,11-20H,10,21-25H2,1H3,(H2,40,41,44,45,47)
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n/an/a 978n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP9 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50350617
PNG
(CHEMBL1812935)
Show SMILES CCOc1cc(OCC)cc(c1)C(=O)N1CCCN(CC1)C1(C(=O)NC(=O)NC1=O)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C32H34N4O7/c1-3-41-26-19-22(20-27(21-26)42-4-2)28(37)35-15-8-16-36(18-17-35)32(29(38)33-31(40)34-30(32)39)23-11-13-25(14-12-23)43-24-9-6-5-7-10-24/h5-7,9-14,19-21H,3-4,8,15-18H2,1-2H3,(H2,33,34,38,39,40)
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n/an/a 1.19E+3n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of AMPA-activated human recombinant MMP9 using fluorogenic substrate (7-methoxycoumarin-4-yl)-acetyl-pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl...

Bioorg Med Chem 19: 4985-99 (2011)


Article DOI: 10.1016/j.bmc.2011.06.055
BindingDB Entry DOI: 10.7270/Q2RJ4JV9
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%