Found 17 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Sphingosine 1-phosphate receptor 4
(Homo sapiens (Human)) | BDBM50352103
(CHEMBL1824254)Show InChI InChI=1S/C21H21NOS/c1-13-8-9-14(2)17(12-13)18-10-11-19(24-18)21(23)22-20-15(3)6-5-7-16(20)4/h5-12H,1-4H3,(H,22,23) | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 59 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute
Curated by ChEMBL
| Assay Description
Antagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16... |
Bioorg Med Chem Lett 21: 5470-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.132
BindingDB Entry DOI: 10.7270/Q2930TH3 |
More data for this
Ligand-Target Pair | |
Sphingosine 1-phosphate receptor 4
(Homo sapiens (Human)) | BDBM50344807
(5-(2,5-dimethylphenyl)-N-(2,6-dimethylphenyl)furan...)Show InChI InChI=1S/C21H21NO2/c1-13-8-9-14(2)17(12-13)18-10-11-19(24-18)21(23)22-20-15(3)6-5-7-16(20)4/h5-12H,1-4H3,(H,22,23) | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 64 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute
Curated by ChEMBL
| Assay Description
Antagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16... |
Bioorg Med Chem Lett 21: 5470-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.132
BindingDB Entry DOI: 10.7270/Q2930TH3 |
More data for this
Ligand-Target Pair | |
Sphingosine 1-phosphate receptor 4
(Homo sapiens (Human)) | BDBM50352108
(CHEMBL1824259)Show SMILES Cc1ccc(C)c(c1)-c1cccc(c1)C(=O)Nc1c(C)cccc1C Show InChI InChI=1S/C23H23NO/c1-15-11-12-16(2)21(13-15)19-9-6-10-20(14-19)23(25)24-22-17(3)7-5-8-18(22)4/h5-14H,1-4H3,(H,24,25) | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 75 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute
Curated by ChEMBL
| Assay Description
Antagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16... |
Bioorg Med Chem Lett 21: 5470-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.132
BindingDB Entry DOI: 10.7270/Q2930TH3 |
More data for this
Ligand-Target Pair | |
Sphingosine 1-phosphate receptor 4
(Homo sapiens (Human)) | BDBM62407
(5-(2,5-dichlorophenyl)-N-(2,6-dimethylphenyl)-2-fu...)Show InChI InChI=1S/C19H15Cl2NO2/c1-11-4-3-5-12(2)18(11)22-19(23)17-9-8-16(24-17)14-10-13(20)6-7-15(14)21/h3-10H,1-2H3,(H,22,23) | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 78 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute
Curated by ChEMBL
| Assay Description
Antagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16... |
Bioorg Med Chem Lett 21: 5470-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.132
BindingDB Entry DOI: 10.7270/Q2930TH3 |
More data for this
Ligand-Target Pair | |
Sphingosine 1-phosphate receptor 4
(Homo sapiens (Human)) | BDBM50352106
(CHEMBL1824257)Show InChI InChI=1S/C22H23NO2/c1-13-9-10-14(2)18(11-13)19-12-17(5)21(25-19)22(24)23-20-15(3)7-6-8-16(20)4/h6-12H,1-5H3,(H,23,24) | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 173 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute
Curated by ChEMBL
| Assay Description
Antagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16... |
Bioorg Med Chem Lett 21: 5470-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.132
BindingDB Entry DOI: 10.7270/Q2930TH3 |
More data for this
Ligand-Target Pair | |
Sphingosine 1-phosphate receptor 4
(Homo sapiens (Human)) | BDBM50352105
(CHEMBL1824256)Show InChI InChI=1S/C21H21NO2/c1-13-8-9-14(2)18(10-13)17-11-19(24-12-17)21(23)22-20-15(3)6-5-7-16(20)4/h5-12H,1-4H3,(H,22,23) | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 211 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute
Curated by ChEMBL
| Assay Description
Antagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16... |
Bioorg Med Chem Lett 21: 5470-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.132
BindingDB Entry DOI: 10.7270/Q2930TH3 |
More data for this
Ligand-Target Pair | |
Sphingosine 1-phosphate receptor 4
(Homo sapiens (Human)) | BDBM50352104
(CHEMBL1824255)Show InChI InChI=1S/C21H21NO2/c1-13-8-9-14(2)18(10-13)19-11-17(12-24-19)21(23)22-20-15(3)6-5-7-16(20)4/h5-12H,1-4H3,(H,22,23) | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 233 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute
Curated by ChEMBL
| Assay Description
Antagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16... |
Bioorg Med Chem Lett 21: 5470-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.132
BindingDB Entry DOI: 10.7270/Q2930TH3 |
More data for this
Ligand-Target Pair | |
Sphingosine 1-phosphate receptor 4
(Homo sapiens (Human)) | BDBM50352107
(CHEMBL1824258)Show InChI InChI=1S/C22H23NO2/c1-13-9-10-14(2)18(11-13)21-17(5)12-19(25-21)22(24)23-20-15(3)7-6-8-16(20)4/h6-12H,1-5H3,(H,23,24) | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 911 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute
Curated by ChEMBL
| Assay Description
Antagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16... |
Bioorg Med Chem Lett 21: 5470-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.132
BindingDB Entry DOI: 10.7270/Q2930TH3 |
More data for this
Ligand-Target Pair | |
Sphingosine 1-phosphate receptor 2
(Homo sapiens (Human)) | BDBM50352103
(CHEMBL1824254)Show InChI InChI=1S/C21H21NOS/c1-13-8-9-14(2)17(12-13)18-10-11-19(24-18)21(23)22-20-15(3)6-5-7-16(20)4/h5-12H,1-4H3,(H,22,23) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute
Curated by ChEMBL
| Assay Description
Antagonist activity at S1P2 receptor |
Bioorg Med Chem Lett 21: 5470-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.132
BindingDB Entry DOI: 10.7270/Q2930TH3 |
More data for this
Ligand-Target Pair | |
Sphingosine 1-phosphate receptor 4
(Homo sapiens (Human)) | BDBM50352109
(CHEMBL1824260)Show SMILES Cc1ccc(C)c(c1)-c1cc(ccc1C)C(=O)Nc1c(C)cccc1C Show InChI InChI=1S/C24H25NO/c1-15-9-10-16(2)21(13-15)22-14-20(12-11-17(22)3)24(26)25-23-18(4)7-6-8-19(23)5/h6-14H,1-5H3,(H,25,26) | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute
Curated by ChEMBL
| Assay Description
Antagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16... |
Bioorg Med Chem Lett 21: 5470-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.132
BindingDB Entry DOI: 10.7270/Q2930TH3 |
More data for this
Ligand-Target Pair | |
Sphingosine 1-phosphate receptor 4
(Homo sapiens (Human)) | BDBM50352102
(CHEMBL1824253)Show SMILES Cc1ccc(C)c(c1)-c1ccc(C(=O)Nc2c(C)cccc2C)n1C Show InChI InChI=1S/C22H24N2O/c1-14-9-10-15(2)18(13-14)19-11-12-20(24(19)5)22(25)23-21-16(3)7-6-8-17(21)4/h6-13H,1-5H3,(H,23,25) | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 6.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute
Curated by ChEMBL
| Assay Description
Antagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16... |
Bioorg Med Chem Lett 21: 5470-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.132
BindingDB Entry DOI: 10.7270/Q2930TH3 |
More data for this
Ligand-Target Pair | |
Sphingosine 1-phosphate receptor 5
(Homo sapiens (Human)) | BDBM62407
(5-(2,5-dichlorophenyl)-N-(2,6-dimethylphenyl)-2-fu...)Show InChI InChI=1S/C19H15Cl2NO2/c1-11-4-3-5-12(2)18(11)22-19(23)17-9-8-16(24-17)14-10-13(20)6-7-15(14)21/h3-10H,1-2H3,(H,22,23) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute
Curated by ChEMBL
| Assay Description
Antagonist activity at S1P5 receptor |
Bioorg Med Chem Lett 21: 5470-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.132
BindingDB Entry DOI: 10.7270/Q2930TH3 |
More data for this
Ligand-Target Pair | |
Sphingosine 1-phosphate receptor 1
(Homo sapiens (Human)) | BDBM50344807
(5-(2,5-dimethylphenyl)-N-(2,6-dimethylphenyl)furan...)Show InChI InChI=1S/C21H21NO2/c1-13-8-9-14(2)17(12-13)18-10-11-19(24-18)21(23)22-20-15(3)6-5-7-16(20)4/h5-12H,1-4H3,(H,22,23) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute
Curated by ChEMBL
| Assay Description
Antagonist activity at S1P1 receptor |
Bioorg Med Chem Lett 21: 5470-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.132
BindingDB Entry DOI: 10.7270/Q2930TH3 |
More data for this
Ligand-Target Pair | |
Sphingosine 1-phosphate receptor 3
(Homo sapiens (Human)) | BDBM62407
(5-(2,5-dichlorophenyl)-N-(2,6-dimethylphenyl)-2-fu...)Show InChI InChI=1S/C19H15Cl2NO2/c1-11-4-3-5-12(2)18(11)22-19(23)17-9-8-16(24-17)14-10-13(20)6-7-15(14)21/h3-10H,1-2H3,(H,22,23) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute
Curated by ChEMBL
| Assay Description
Antagonist activity at S1P3 receptor |
Bioorg Med Chem Lett 21: 5470-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.132
BindingDB Entry DOI: 10.7270/Q2930TH3 |
More data for this
Ligand-Target Pair | |
Sphingosine 1-phosphate receptor 1
(Homo sapiens (Human)) | BDBM62407
(5-(2,5-dichlorophenyl)-N-(2,6-dimethylphenyl)-2-fu...)Show InChI InChI=1S/C19H15Cl2NO2/c1-11-4-3-5-12(2)18(11)22-19(23)17-9-8-16(24-17)14-10-13(20)6-7-15(14)21/h3-10H,1-2H3,(H,22,23) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| Purchase
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute
Curated by ChEMBL
| Assay Description
Antagonist activity at S1P1 receptor |
Bioorg Med Chem Lett 21: 5470-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.132
BindingDB Entry DOI: 10.7270/Q2930TH3 |
More data for this
Ligand-Target Pair | |
Sphingosine 1-phosphate receptor 3
(Homo sapiens (Human)) | BDBM50344807
(5-(2,5-dimethylphenyl)-N-(2,6-dimethylphenyl)furan...)Show InChI InChI=1S/C21H21NO2/c1-13-8-9-14(2)17(12-13)18-10-11-19(24-18)21(23)22-20-15(3)6-5-7-16(20)4/h5-12H,1-4H3,(H,22,23) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute
Curated by ChEMBL
| Assay Description
Antagonist activity at S1P3 receptor |
Bioorg Med Chem Lett 21: 5470-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.132
BindingDB Entry DOI: 10.7270/Q2930TH3 |
More data for this
Ligand-Target Pair | |
Sphingosine 1-phosphate receptor 5
(Homo sapiens (Human)) | BDBM50344807
(5-(2,5-dimethylphenyl)-N-(2,6-dimethylphenyl)furan...)Show InChI InChI=1S/C21H21NO2/c1-13-8-9-14(2)17(12-13)18-10-11-19(24-18)21(23)22-20-15(3)6-5-7-16(20)4/h5-12H,1-4H3,(H,22,23) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute
Curated by ChEMBL
| Assay Description
Antagonist activity at S1P5 receptor |
Bioorg Med Chem Lett 21: 5470-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.132
BindingDB Entry DOI: 10.7270/Q2930TH3 |
More data for this
Ligand-Target Pair | |
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