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PubMed code 21835616

Compile data set for download or QSAR
Found 41 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50419102
PNG
(CHEMBL1824369)
Show SMILES Oc1cccc(NC(=O)c2ccc(OCCCN3CCCC3)cc2OCc2ccccc2C#N)c1
Show InChI InChI=1S/C28H29N3O4/c29-19-21-7-1-2-8-22(21)20-35-27-18-25(34-16-6-15-31-13-3-4-14-31)11-12-26(27)28(33)30-23-9-5-10-24(32)17-23/h1-2,5,7-12,17-18,32H,3-4,6,13-16,20H2,(H,30,33)
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n/an/a 17.4n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of recombinant GST-tagged wild type c-met kinase domain (residues 1056-1371) using biotin-poly EAY as substrate in the presence of ATP aft...

Bioorg Med Chem Lett 21: 5224-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.047
BindingDB Entry DOI: 10.7270/Q2K35VX8
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50419101
PNG
(CHEMBL1824368)
Show SMILES Oc1cccc(NC(=O)c2ccc(OCCCN3CCCC3)cc2OCc2ccccc2F)c1
Show InChI InChI=1S/C27H29FN2O4/c28-25-10-2-1-7-20(25)19-34-26-18-23(33-16-6-15-30-13-3-4-14-30)11-12-24(26)27(32)29-21-8-5-9-22(31)17-21/h1-2,5,7-12,17-18,31H,3-4,6,13-16,19H2,(H,29,32)
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n/an/a 40.7n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of recombinant GST-tagged wild type c-met kinase domain (residues 1056-1371) using biotin-poly EAY as substrate in the presence of ATP aft...

Bioorg Med Chem Lett 21: 5224-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.047
BindingDB Entry DOI: 10.7270/Q2K35VX8
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50419123
PNG
(CHEMBL1824371)
Show SMILES Oc1cccc(NC(=O)c2ccc(OCCCN3CCCC3)cc2OCc2cccc(F)c2)c1
Show InChI InChI=1S/C27H29FN2O4/c28-21-7-3-6-20(16-21)19-34-26-18-24(33-15-5-14-30-12-1-2-13-30)10-11-25(26)27(32)29-22-8-4-9-23(31)17-22/h3-4,6-11,16-18,31H,1-2,5,12-15,19H2,(H,29,32)
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n/an/a 55.0n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of recombinant GST-tagged wild type c-met kinase domain (residues 1056-1371) using biotin-poly EAY as substrate in the presence of ATP aft...

Bioorg Med Chem Lett 21: 5224-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.047
BindingDB Entry DOI: 10.7270/Q2K35VX8
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50419103
PNG
(CHEMBL1824370)
Show SMILES Oc1cccc(NC(=O)c2ccc(OCCCN3CCCC3)cc2OCc2c(F)cccc2F)c1
Show InChI InChI=1S/C27H28F2N2O4/c28-24-8-4-9-25(29)23(24)18-35-26-17-21(34-15-5-14-31-12-1-2-13-31)10-11-22(26)27(33)30-19-6-3-7-20(32)16-19/h3-4,6-11,16-17,32H,1-2,5,12-15,18H2,(H,30,33)
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n/an/a 69.2n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of recombinant GST-tagged wild type c-met kinase domain (residues 1056-1371) using biotin-poly EAY as substrate in the presence of ATP aft...

Bioorg Med Chem Lett 21: 5224-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.047
BindingDB Entry DOI: 10.7270/Q2K35VX8
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50419105
PNG
(CHEMBL1824373)
Show SMILES Oc1cccc(NC(=O)c2ccc(OCCCN3CCCC3)cc2OCc2cccc(c2)C#N)c1
Show InChI InChI=1S/C28H29N3O4/c29-19-21-6-3-7-22(16-21)20-35-27-18-25(34-15-5-14-31-12-1-2-13-31)10-11-26(27)28(33)30-23-8-4-9-24(32)17-23/h3-4,6-11,16-18,32H,1-2,5,12-15,20H2,(H,30,33)
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n/an/a 85.1n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of recombinant GST-tagged wild type c-met kinase domain (residues 1056-1371) using biotin-poly EAY as substrate in the presence of ATP aft...

Bioorg Med Chem Lett 21: 5224-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.047
BindingDB Entry DOI: 10.7270/Q2K35VX8
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50419104
PNG
(CHEMBL1824372)
Show SMILES Oc1cccc(NC(=O)c2ccc(OCCCN3CCCC3)cc2OCc2cccc(Cl)c2)c1
Show InChI InChI=1S/C27H29ClN2O4/c28-21-7-3-6-20(16-21)19-34-26-18-24(33-15-5-14-30-12-1-2-13-30)10-11-25(26)27(32)29-22-8-4-9-23(31)17-22/h3-4,6-11,16-18,31H,1-2,5,12-15,19H2,(H,29,32)
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n/an/a 97.7n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of recombinant GST-tagged wild type c-met kinase domain (residues 1056-1371) using biotin-poly EAY as substrate in the presence of ATP aft...

Bioorg Med Chem Lett 21: 5224-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.047
BindingDB Entry DOI: 10.7270/Q2K35VX8
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50419099
PNG
(CHEMBL1824364)
Show SMILES Oc1cccc(NC(=O)c2ccc(OCCCN3CCCC3)cc2OCc2ccc(F)cc2)c1
Show InChI InChI=1S/C27H29FN2O4/c28-21-9-7-20(8-10-21)19-34-26-18-24(33-16-4-15-30-13-1-2-14-30)11-12-25(26)27(32)29-22-5-3-6-23(31)17-22/h3,5-12,17-18,31H,1-2,4,13-16,19H2,(H,29,32)
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n/an/a 110n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of recombinant GST-tagged wild type c-met kinase domain (residues 1056-1371) using biotin-poly EAY as substrate in the presence of ATP aft...

Bioorg Med Chem Lett 21: 5224-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.047
BindingDB Entry DOI: 10.7270/Q2K35VX8
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50419117
PNG
(CHEMBL1824374)
Show SMILES Oc1cccc(NC(=O)c2ccc(OCCCN3CCCC3)cc2OCc2cccc(c2)[N+]([O-])=O)c1
Show InChI InChI=1S/C27H29N3O6/c31-23-9-4-7-21(17-23)28-27(32)25-11-10-24(35-15-5-14-29-12-1-2-13-29)18-26(25)36-19-20-6-3-8-22(16-20)30(33)34/h3-4,6-11,16-18,31H,1-2,5,12-15,19H2,(H,28,32)
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n/an/a 126n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of recombinant GST-tagged wild type c-met kinase domain (residues 1056-1371) using biotin-poly EAY as substrate in the presence of ATP aft...

Bioorg Med Chem Lett 21: 5224-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.047
BindingDB Entry DOI: 10.7270/Q2K35VX8
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50419100
PNG
(CHEMBL1824367)
Show SMILES Cc1ccccc1COc1cc(OCCCN2CCCC2)ccc1C(=O)Nc1cccc(O)c1
Show InChI InChI=1S/C28H32N2O4/c1-21-8-2-3-9-22(21)20-34-27-19-25(33-17-7-16-30-14-4-5-15-30)12-13-26(27)28(32)29-23-10-6-11-24(31)18-23/h2-3,6,8-13,18-19,31H,4-5,7,14-17,20H2,1H3,(H,29,32)
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n/an/a 126n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of recombinant GST-tagged wild type c-met kinase domain (residues 1056-1371) using biotin-poly EAY as substrate in the presence of ATP aft...

Bioorg Med Chem Lett 21: 5224-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.047
BindingDB Entry DOI: 10.7270/Q2K35VX8
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50419114
PNG
(CHEMBL1824363)
Show SMILES Oc1cccc(NC(=O)c2ccc(OCCCN3CCCC3)cc2OCc2ccccc2)c1
Show InChI InChI=1S/C27H30N2O4/c30-23-11-6-10-22(18-23)28-27(31)25-13-12-24(32-17-7-16-29-14-4-5-15-29)19-26(25)33-20-21-8-2-1-3-9-21/h1-3,6,8-13,18-19,30H,4-5,7,14-17,20H2,(H,28,31)
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n/an/a 155n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of recombinant GST-tagged wild type c-met kinase domain (residues 1056-1371) using biotin-poly EAY as substrate in the presence of ATP aft...

Bioorg Med Chem Lett 21: 5224-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.047
BindingDB Entry DOI: 10.7270/Q2K35VX8
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50419111
PNG
(CHEMBL1824382)
Show SMILES O=C(Nc1ccccc1)c1ccc(OCCCN2CCCC2)cc1OCc1ccccc1
Show InChI InChI=1S/C27H30N2O3/c30-27(28-23-12-5-2-6-13-23)25-15-14-24(31-19-9-18-29-16-7-8-17-29)20-26(25)32-21-22-10-3-1-4-11-22/h1-6,10-15,20H,7-9,16-19,21H2,(H,28,30)
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n/an/a 339n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of recombinant GST-tagged wild type c-met kinase domain (residues 1056-1371) using biotin-poly EAY as substrate in the presence of ATP aft...

Bioorg Med Chem Lett 21: 5224-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.047
BindingDB Entry DOI: 10.7270/Q2K35VX8
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50419110
PNG
(CHEMBL1824381)
Show SMILES Oc1cccc(NC(=O)c2ccc(OCCCN3CCCC3)cc2OC2CCCC2)c1
Show InChI InChI=1S/C25H32N2O4/c28-20-8-5-7-19(17-20)26-25(29)23-12-11-22(18-24(23)31-21-9-1-2-10-21)30-16-6-15-27-13-3-4-14-27/h5,7-8,11-12,17-18,21,28H,1-4,6,9-10,13-16H2,(H,26,29)
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n/an/a 398n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of recombinant GST-tagged wild type c-met kinase domain (residues 1056-1371) using biotin-poly EAY as substrate in the presence of ATP aft...

Bioorg Med Chem Lett 21: 5224-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.047
BindingDB Entry DOI: 10.7270/Q2K35VX8
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50419106
PNG
(CHEMBL1824375)
Show SMILES Oc1cccc(NC(=O)c2ccc(OCCCN3CCCC3)cc2OCc2cccnc2)c1
Show InChI InChI=1S/C26H29N3O4/c30-22-8-3-7-21(16-22)28-26(31)24-10-9-23(32-15-5-14-29-12-1-2-13-29)17-25(24)33-19-20-6-4-11-27-18-20/h3-4,6-11,16-18,30H,1-2,5,12-15,19H2,(H,28,31)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of recombinant GST-tagged wild type c-met kinase domain (residues 1056-1371) using biotin-poly EAY as substrate in the presence of ATP aft...

Bioorg Med Chem Lett 21: 5224-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.047
BindingDB Entry DOI: 10.7270/Q2K35VX8
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50419116
PNG
(CHEMBL1824608)
Show SMILES Fc1cccc(COc2cc(OCCCN3CCCC3)ccc2C(=O)Nc2ccccc2)c1
Show InChI InChI=1S/C27H29FN2O3/c28-22-9-6-8-21(18-22)20-33-26-19-24(32-17-7-16-30-14-4-5-15-30)12-13-25(26)27(31)29-23-10-2-1-3-11-23/h1-3,6,8-13,18-19H,4-5,7,14-17,20H2,(H,29,31)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of recombinant GST-tagged wild type c-met kinase domain (residues 1056-1371) using biotin-poly EAY as substrate in the presence of ATP aft...

Bioorg Med Chem Lett 21: 5224-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.047
BindingDB Entry DOI: 10.7270/Q2K35VX8
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50419097
PNG
(CHEMBL1824606)
Show SMILES Fc1ccccc1COc1cc(OCCCN2CCCC2)ccc1C(=O)Nc1ccccc1
Show InChI InChI=1S/C27H29FN2O3/c28-25-12-5-4-9-21(25)20-33-26-19-23(32-18-8-17-30-15-6-7-16-30)13-14-24(26)27(31)29-22-10-2-1-3-11-22/h1-5,9-14,19H,6-8,15-18,20H2,(H,29,31)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of recombinant GST-tagged wild type c-met kinase domain (residues 1056-1371) using biotin-poly EAY as substrate in the presence of ATP aft...

Bioorg Med Chem Lett 21: 5224-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.047
BindingDB Entry DOI: 10.7270/Q2K35VX8
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50419121
PNG
(CHEMBL1824605)
Show SMILES O=C(Nc1ccccc1)c1ccc(OCCCN2CCCC2)cc1OCc1ccccc1C#N
Show InChI InChI=1S/C28H29N3O3/c29-20-22-9-4-5-10-23(22)21-34-27-19-25(33-18-8-17-31-15-6-7-16-31)13-14-26(27)28(32)30-24-11-2-1-3-12-24/h1-5,9-14,19H,6-8,15-18,21H2,(H,30,32)
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n/an/a 562n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of recombinant GST-tagged wild type c-met kinase domain (residues 1056-1371) using biotin-poly EAY as substrate in the presence of ATP aft...

Bioorg Med Chem Lett 21: 5224-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.047
BindingDB Entry DOI: 10.7270/Q2K35VX8
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50419107
PNG
(CHEMBL1824376)
Show SMILES Oc1cccc(NC(=O)c2ccc(OCCCN3CCCC3)cc2OCc2ccccn2)c1
Show InChI InChI=1S/C26H29N3O4/c30-22-9-5-8-20(17-22)28-26(31)24-11-10-23(32-16-6-15-29-13-3-4-14-29)18-25(24)33-19-21-7-1-2-12-27-21/h1-2,5,7-12,17-18,30H,3-4,6,13-16,19H2,(H,28,31)
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n/an/a 562n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of recombinant GST-tagged wild type c-met kinase domain (residues 1056-1371) using biotin-poly EAY as substrate in the presence of ATP aft...

Bioorg Med Chem Lett 21: 5224-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.047
BindingDB Entry DOI: 10.7270/Q2K35VX8
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50419119
PNG
(CHEMBL1824607)
Show SMILES O=C(Nc1ccccc1)c1ccc(OCCCN2CCCC2)cc1OCc1cccc(c1)C#N
Show InChI InChI=1S/C28H29N3O3/c29-20-22-8-6-9-23(18-22)21-34-27-19-25(33-17-7-16-31-14-4-5-15-31)12-13-26(27)28(32)30-24-10-2-1-3-11-24/h1-3,6,8-13,18-19H,4-5,7,14-17,21H2,(H,30,32)
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n/an/a 617n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of recombinant GST-tagged wild type c-met kinase domain (residues 1056-1371) using biotin-poly EAY as substrate in the presence of ATP aft...

Bioorg Med Chem Lett 21: 5224-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.047
BindingDB Entry DOI: 10.7270/Q2K35VX8
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50419124
PNG
(CHEMBL1824377)
Show SMILES Oc1cccc(NC(=O)c2ccc(OCCCN3CCCC3)cc2OCc2cscn2)c1
Show InChI InChI=1S/C24H27N3O4S/c28-20-6-3-5-18(13-20)26-24(29)22-8-7-21(30-12-4-11-27-9-1-2-10-27)14-23(22)31-15-19-16-32-17-25-19/h3,5-8,13-14,16-17,28H,1-2,4,9-12,15H2,(H,26,29)
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n/an/a 646n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of recombinant GST-tagged wild type c-met kinase domain (residues 1056-1371) using biotin-poly EAY as substrate in the presence of ATP aft...

Bioorg Med Chem Lett 21: 5224-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.047
BindingDB Entry DOI: 10.7270/Q2K35VX8
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50419120
PNG
(CHEMBL1824379)
Show SMILES CCCOc1cc(OCCCN2CCCC2)ccc1C(=O)Nc1cccc(O)c1
Show InChI InChI=1S/C23H30N2O4/c1-2-14-29-22-17-20(28-15-6-13-25-11-3-4-12-25)9-10-21(22)23(27)24-18-7-5-8-19(26)16-18/h5,7-10,16-17,26H,2-4,6,11-15H2,1H3,(H,24,27)
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n/an/a 646n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of recombinant GST-tagged wild type c-met kinase domain (residues 1056-1371) using biotin-poly EAY as substrate in the presence of ATP aft...

Bioorg Med Chem Lett 21: 5224-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.047
BindingDB Entry DOI: 10.7270/Q2K35VX8
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50419122
PNG
(CHEMBL1824365)
Show SMILES Oc1cccc(NC(=O)c2ccc(OCCCN3CCCC3)cc2OCc2ccc(Cl)cc2)c1
Show InChI InChI=1S/C27H29ClN2O4/c28-21-9-7-20(8-10-21)19-34-26-18-24(33-16-4-15-30-13-1-2-14-30)11-12-25(26)27(32)29-22-5-3-6-23(31)17-22/h3,5-12,17-18,31H,1-2,4,13-16,19H2,(H,29,32)
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n/an/a 851n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of recombinant GST-tagged wild type c-met kinase domain (residues 1056-1371) using biotin-poly EAY as substrate in the presence of ATP aft...

Bioorg Med Chem Lett 21: 5224-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.047
BindingDB Entry DOI: 10.7270/Q2K35VX8
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50419109
PNG
(CHEMBL1824380)
Show SMILES CCC(C)COc1cc(OCCCN2CCCC2)ccc1C(=O)Nc1cccc(O)c1
Show InChI InChI=1S/C25H34N2O4/c1-3-19(2)18-31-24-17-22(30-15-7-14-27-12-4-5-13-27)10-11-23(24)25(29)26-20-8-6-9-21(28)16-20/h6,8-11,16-17,19,28H,3-5,7,12-15,18H2,1-2H3,(H,26,29)
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n/an/a 912n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of recombinant GST-tagged wild type c-met kinase domain (residues 1056-1371) using biotin-poly EAY as substrate in the presence of ATP aft...

Bioorg Med Chem Lett 21: 5224-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.047
BindingDB Entry DOI: 10.7270/Q2K35VX8
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50419115
PNG
(CHEMBL1824383)
Show SMILES Fc1cccc(NC(=O)c2ccc(OCCCN3CCCC3)cc2OCc2ccccc2)c1
Show InChI InChI=1S/C27H29FN2O3/c28-22-10-6-11-23(18-22)29-27(31)25-13-12-24(32-17-7-16-30-14-4-5-15-30)19-26(25)33-20-21-8-2-1-3-9-21/h1-3,6,8-13,18-19H,4-5,7,14-17,20H2,(H,29,31)
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n/an/a 1.07E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of recombinant GST-tagged wild type c-met kinase domain (residues 1056-1371) using biotin-poly EAY as substrate in the presence of ATP aft...

Bioorg Med Chem Lett 21: 5224-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.047
BindingDB Entry DOI: 10.7270/Q2K35VX8
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50419091
PNG
(CHEMBL1824598)
Show SMILES CNC(=O)c1cccc(NC(=O)c2ccc(OCCCN3CCCC3)cc2OCc2ccccc2)c1
Show InChI InChI=1S/C29H33N3O4/c1-30-28(33)23-11-7-12-24(19-23)31-29(34)26-14-13-25(35-18-8-17-32-15-5-6-16-32)20-27(26)36-21-22-9-3-2-4-10-22/h2-4,7,9-14,19-20H,5-6,8,15-18,21H2,1H3,(H,30,33)(H,31,34)
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n/an/a 1.15E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of recombinant GST-tagged wild type c-met kinase domain (residues 1056-1371) using biotin-poly EAY as substrate in the presence of ATP aft...

Bioorg Med Chem Lett 21: 5224-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.047
BindingDB Entry DOI: 10.7270/Q2K35VX8
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50419090
PNG
(CHEMBL1821756)
Show SMILES NC(=O)c1cccc(NC(=O)c2ccc(OCCCN3CCCC3)cc2OCc2ccccc2)c1
Show InChI InChI=1S/C28H31N3O4/c29-27(32)22-10-6-11-23(18-22)30-28(33)25-13-12-24(34-17-7-16-31-14-4-5-15-31)19-26(25)35-20-21-8-2-1-3-9-21/h1-3,6,8-13,18-19H,4-5,7,14-17,20H2,(H2,29,32)(H,30,33)
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n/an/a 1.23E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of recombinant GST-tagged wild type c-met kinase domain (residues 1056-1371) using biotin-poly EAY as substrate in the presence of ATP aft...

Bioorg Med Chem Lett 21: 5224-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.047
BindingDB Entry DOI: 10.7270/Q2K35VX8
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50419113
PNG
(CHEMBL1824386)
Show SMILES Cc1ccc(NC(=O)c2ccc(OCCCN3CCCC3)cc2OCc2ccccc2)cc1O
Show InChI InChI=1S/C28H32N2O4/c1-21-10-11-23(18-26(21)31)29-28(32)25-13-12-24(33-17-7-16-30-14-5-6-15-30)19-27(25)34-20-22-8-3-2-4-9-22/h2-4,8-13,18-19,31H,5-7,14-17,20H2,1H3,(H,29,32)
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n/an/a 1.35E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of recombinant GST-tagged wild type c-met kinase domain (residues 1056-1371) using biotin-poly EAY as substrate in the presence of ATP aft...

Bioorg Med Chem Lett 21: 5224-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.047
BindingDB Entry DOI: 10.7270/Q2K35VX8
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50419126
PNG
(CHEMBL1824390)
Show SMILES O=C(Nc1cccc(c1)C#N)c1ccc(OCCCN2CCCC2)cc1OCc1ccccc1
Show InChI InChI=1S/C28H29N3O3/c29-20-23-10-6-11-24(18-23)30-28(32)26-13-12-25(33-17-7-16-31-14-4-5-15-31)19-27(26)34-21-22-8-2-1-3-9-22/h1-3,6,8-13,18-19H,4-5,7,14-17,21H2,(H,30,32)
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n/an/a 1.55E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of recombinant GST-tagged wild type c-met kinase domain (residues 1056-1371) using biotin-poly EAY as substrate in the presence of ATP aft...

Bioorg Med Chem Lett 21: 5224-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.047
BindingDB Entry DOI: 10.7270/Q2K35VX8
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50419093
PNG
(CHEMBL1824600)
Show SMILES Nc1cccc(NC(=O)c2ccc(OCCCN3CCCC3)cc2OCc2ccccc2)c1
Show InChI InChI=1S/C27H31N3O3/c28-22-10-6-11-23(18-22)29-27(31)25-13-12-24(32-17-7-16-30-14-4-5-15-30)19-26(25)33-20-21-8-2-1-3-9-21/h1-3,6,8-13,18-19H,4-5,7,14-17,20,28H2,(H,29,31)
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n/an/a 1.62E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of recombinant GST-tagged wild type c-met kinase domain (residues 1056-1371) using biotin-poly EAY as substrate in the presence of ATP aft...

Bioorg Med Chem Lett 21: 5224-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.047
BindingDB Entry DOI: 10.7270/Q2K35VX8
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50419112
PNG
(CHEMBL1824385)
Show SMILES Brc1cccc(NC(=O)c2ccc(OCCCN3CCCC3)cc2OCc2ccccc2)c1
Show InChI InChI=1S/C27H29BrN2O3/c28-22-10-6-11-23(18-22)29-27(31)25-13-12-24(32-17-7-16-30-14-4-5-15-30)19-26(25)33-20-21-8-2-1-3-9-21/h1-3,6,8-13,18-19H,4-5,7,14-17,20H2,(H,29,31)
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n/an/a 2.40E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of recombinant GST-tagged wild type c-met kinase domain (residues 1056-1371) using biotin-poly EAY as substrate in the presence of ATP aft...

Bioorg Med Chem Lett 21: 5224-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.047
BindingDB Entry DOI: 10.7270/Q2K35VX8
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50419088
PNG
(CHEMBL1824387)
Show SMILES COc1cccc(NC(=O)c2ccc(OCCCN3CCCC3)cc2OCc2ccccc2)c1
Show InChI InChI=1S/C28H32N2O4/c1-32-24-12-7-11-23(19-24)29-28(31)26-14-13-25(33-18-8-17-30-15-5-6-16-30)20-27(26)34-21-22-9-3-2-4-10-22/h2-4,7,9-14,19-20H,5-6,8,15-18,21H2,1H3,(H,29,31)
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n/an/a 2.45E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of recombinant GST-tagged wild type c-met kinase domain (residues 1056-1371) using biotin-poly EAY as substrate in the presence of ATP aft...

Bioorg Med Chem Lett 21: 5224-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.047
BindingDB Entry DOI: 10.7270/Q2K35VX8
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50419127
PNG
(CHEMBL1824601)
Show SMILES O=C(Nc1ccc2CCNc2c1)c1ccc(OCCCN2CCCC2)cc1OCc1ccccc1
Show InChI InChI=1S/C29H33N3O3/c33-29(31-24-10-9-23-13-14-30-27(23)19-24)26-12-11-25(34-18-6-17-32-15-4-5-16-32)20-28(26)35-21-22-7-2-1-3-8-22/h1-3,7-12,19-20,30H,4-6,13-18,21H2,(H,31,33)
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n/an/a 2.88E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of recombinant GST-tagged wild type c-met kinase domain (residues 1056-1371) using biotin-poly EAY as substrate in the presence of ATP aft...

Bioorg Med Chem Lett 21: 5224-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.047
BindingDB Entry DOI: 10.7270/Q2K35VX8
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50419118
PNG
(CHEMBL1824388)
Show SMILES O=C(Nc1cccnc1)c1ccc(OCCCN2CCCC2)cc1OCc1ccccc1
Show InChI InChI=1S/C26H29N3O3/c30-26(28-22-10-6-13-27-19-22)24-12-11-23(31-17-7-16-29-14-4-5-15-29)18-25(24)32-20-21-8-2-1-3-9-21/h1-3,6,8-13,18-19H,4-5,7,14-17,20H2,(H,28,30)
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n/an/a 3.24E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of recombinant GST-tagged wild type c-met kinase domain (residues 1056-1371) using biotin-poly EAY as substrate in the presence of ATP aft...

Bioorg Med Chem Lett 21: 5224-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.047
BindingDB Entry DOI: 10.7270/Q2K35VX8
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50419108
PNG
(CHEMBL1824378)
Show SMILES CCOc1cc(OCCCN2CCCC2)ccc1C(=O)Nc1cccc(O)c1
Show InChI InChI=1S/C22H28N2O4/c1-2-27-21-16-19(28-14-6-13-24-11-3-4-12-24)9-10-20(21)22(26)23-17-7-5-8-18(25)15-17/h5,7-10,15-16,25H,2-4,6,11-14H2,1H3,(H,23,26)
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n/an/a 3.55E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of recombinant GST-tagged wild type c-met kinase domain (residues 1056-1371) using biotin-poly EAY as substrate in the presence of ATP aft...

Bioorg Med Chem Lett 21: 5224-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.047
BindingDB Entry DOI: 10.7270/Q2K35VX8
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50419128
PNG
(CHEMBL1824609)
Show SMILES O=C(Nc1ccccc1)c1ccc(OCCCN2CCCC2)cc1OCc1cccnc1
Show InChI InChI=1S/C26H29N3O3/c30-26(28-22-9-2-1-3-10-22)24-12-11-23(31-17-7-16-29-14-4-5-15-29)18-25(24)32-20-21-8-6-13-27-19-21/h1-3,6,8-13,18-19H,4-5,7,14-17,20H2,(H,28,30)
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n/an/a 3.89E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of recombinant GST-tagged wild type c-met kinase domain (residues 1056-1371) using biotin-poly EAY as substrate in the presence of ATP aft...

Bioorg Med Chem Lett 21: 5224-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.047
BindingDB Entry DOI: 10.7270/Q2K35VX8
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50419094
PNG
(CHEMBL1824602)
Show SMILES O=C(Nc1ccc2cn[nH]c2c1)c1ccc(OCCCN2CCCC2)cc1OCc1ccccc1
Show InChI InChI=1S/C28H30N4O3/c33-28(30-23-10-9-22-19-29-31-26(22)17-23)25-12-11-24(34-16-6-15-32-13-4-5-14-32)18-27(25)35-20-21-7-2-1-3-8-21/h1-3,7-12,17-19H,4-6,13-16,20H2,(H,29,31)(H,30,33)
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n/an/a 5.50E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of recombinant GST-tagged wild type c-met kinase domain (residues 1056-1371) using biotin-poly EAY as substrate in the presence of ATP aft...

Bioorg Med Chem Lett 21: 5224-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.047
BindingDB Entry DOI: 10.7270/Q2K35VX8
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50419095
PNG
(CHEMBL1824603)
Show SMILES CS(=O)(=O)Nc1cccc(NC(=O)c2ccc(OCCCN3CCCC3)cc2OCc2ccccc2)c1
Show InChI InChI=1S/C28H33N3O5S/c1-37(33,34)30-24-12-7-11-23(19-24)29-28(32)26-14-13-25(35-18-8-17-31-15-5-6-16-31)20-27(26)36-21-22-9-3-2-4-10-22/h2-4,7,9-14,19-20,30H,5-6,8,15-18,21H2,1H3,(H,29,32)
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n/an/a 6.17E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of recombinant GST-tagged wild type c-met kinase domain (residues 1056-1371) using biotin-poly EAY as substrate in the presence of ATP aft...

Bioorg Med Chem Lett 21: 5224-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.047
BindingDB Entry DOI: 10.7270/Q2K35VX8
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50419089
PNG
(CHEMBL1824389)
Show SMILES O=C(Nc1ccccn1)c1ccc(OCCCN2CCCC2)cc1OCc1ccccc1
Show InChI InChI=1S/C26H29N3O3/c30-26(28-25-11-4-5-14-27-25)23-13-12-22(31-18-8-17-29-15-6-7-16-29)19-24(23)32-20-21-9-2-1-3-10-21/h1-5,9-14,19H,6-8,15-18,20H2,(H,27,28,30)
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n/an/a 7.94E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of recombinant GST-tagged wild type c-met kinase domain (residues 1056-1371) using biotin-poly EAY as substrate in the presence of ATP aft...

Bioorg Med Chem Lett 21: 5224-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.047
BindingDB Entry DOI: 10.7270/Q2K35VX8
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50419125
PNG
(CHEMBL1824384)
Show SMILES Clc1cccc(NC(=O)c2ccc(OCCCN3CCCC3)cc2OCc2ccccc2)c1
Show InChI InChI=1S/C27H29ClN2O3/c28-22-10-6-11-23(18-22)29-27(31)25-13-12-24(32-17-7-16-30-14-4-5-15-30)19-26(25)33-20-21-8-2-1-3-9-21/h1-3,6,8-13,18-19H,4-5,7,14-17,20H2,(H,29,31)
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n/an/a 9.55E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of recombinant GST-tagged wild type c-met kinase domain (residues 1056-1371) using biotin-poly EAY as substrate in the presence of ATP aft...

Bioorg Med Chem Lett 21: 5224-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.047
BindingDB Entry DOI: 10.7270/Q2K35VX8
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50419098
PNG
(CHEMBL1824610)
Show SMILES O=C(Nc1ccccc1)c1ccc(OCCCN2CCCC2)cc1OCc1ccccn1
Show InChI InChI=1S/C26H29N3O3/c30-26(28-21-9-2-1-3-10-21)24-13-12-23(31-18-8-17-29-15-6-7-16-29)19-25(24)32-20-22-11-4-5-14-27-22/h1-5,9-14,19H,6-8,15-18,20H2,(H,28,30)
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n/an/a 9.55E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of recombinant GST-tagged wild type c-met kinase domain (residues 1056-1371) using biotin-poly EAY as substrate in the presence of ATP aft...

Bioorg Med Chem Lett 21: 5224-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.047
BindingDB Entry DOI: 10.7270/Q2K35VX8
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50419096
PNG
(CHEMBL1824604)
Show SMILES Oc1cccc(NC(=O)c2ccc(OCCCN3CCCC3)cc2O)c1
Show InChI InChI=1S/C20H24N2O4/c23-16-6-3-5-15(13-16)21-20(25)18-8-7-17(14-19(18)24)26-12-4-11-22-9-1-2-10-22/h3,5-8,13-14,23-24H,1-2,4,9-12H2,(H,21,25)
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n/an/a 1.38E+4n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of recombinant GST-tagged wild type c-met kinase domain (residues 1056-1371) using biotin-poly EAY as substrate in the presence of ATP aft...

Bioorg Med Chem Lett 21: 5224-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.047
BindingDB Entry DOI: 10.7270/Q2K35VX8
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50419092
PNG
(CHEMBL1824599)
Show SMILES CN(C)C(=O)c1cccc(NC(=O)c2ccc(OCCCN3CCCC3)cc2OCc2ccccc2)c1
Show InChI InChI=1S/C30H35N3O4/c1-32(2)30(35)24-12-8-13-25(20-24)31-29(34)27-15-14-26(36-19-9-18-33-16-6-7-17-33)21-28(27)37-22-23-10-4-3-5-11-23/h3-5,8,10-15,20-21H,6-7,9,16-19,22H2,1-2H3,(H,31,34)
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n/an/a>1.00E+5n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of recombinant GST-tagged wild type c-met kinase domain (residues 1056-1371) using biotin-poly EAY as substrate in the presence of ATP aft...

Bioorg Med Chem Lett 21: 5224-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.047
BindingDB Entry DOI: 10.7270/Q2K35VX8
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%