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PubMed code 21950613

Compile data set for download or QSAR
Found 31 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50360256
PNG
(CHEMBL1928201)
Show SMILES CN(C)CCCNc1nc(NCCc2ccc(F)cc2)nc(NCCc2ccc(F)cc2)n1
Show InChI InChI=1S/C24H31F2N7/c1-33(2)17-3-14-27-22-30-23(28-15-12-18-4-8-20(25)9-5-18)32-24(31-22)29-16-13-19-6-10-21(26)11-7-19/h4-11H,3,12-17H2,1-2H3,(H3,27,28,29,30,31,32)
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n/an/a 50n/an/an/an/an/an/a



Institut de Qu£mica Avan£ada de Catalunya

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV1 expressed in Xenopus laevis oocytes assessed as blockage of capsaicin-induced current at holding potential -60 mV by...

J Med Chem 54: 7441-52 (2011)


Article DOI: 10.1021/jm200981s
BindingDB Entry DOI: 10.7270/Q2M32W6F
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50360257
PNG
(CHEMBL1928202)
Show SMILES CN(C)CCCCCNc1nc(NCCc2ccc(F)cc2)nc(NCCc2ccc(F)cc2)n1
Show InChI InChI=1S/C26H35F2N7/c1-35(2)19-5-3-4-16-29-24-32-25(30-17-14-20-6-10-22(27)11-7-20)34-26(33-24)31-18-15-21-8-12-23(28)13-9-21/h6-13H,3-5,14-19H2,1-2H3,(H3,29,30,31,32,33,34)
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n/an/a 100n/an/an/an/an/an/a



Institut de Qu£mica Avan£ada de Catalunya

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV1 expressed in Xenopus laevis oocytes assessed as blockage of capsaicin-induced current at holding potential -60 mV by...

J Med Chem 54: 7441-52 (2011)


Article DOI: 10.1021/jm200981s
BindingDB Entry DOI: 10.7270/Q2M32W6F
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50360242
PNG
(CHEMBL1928218)
Show SMILES CN(C)CCCNc1nc(NCCc2cccc(F)c2)nc(NCCc2cccc(F)c2)n1
Show InChI InChI=1S/C24H31F2N7/c1-33(2)15-5-12-27-22-30-23(28-13-10-18-6-3-8-20(25)16-18)32-24(31-22)29-14-11-19-7-4-9-21(26)17-19/h3-4,6-9,16-17H,5,10-15H2,1-2H3,(H3,27,28,29,30,31,32)
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n/an/a 300n/an/an/an/an/an/a



Institut de Qu£mica Avan£ada de Catalunya

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV1 expressed in Xenopus laevis oocytes assessed as blockage of capsaicin-induced current at holding potential -60 mV by...

J Med Chem 54: 7441-52 (2011)


Article DOI: 10.1021/jm200981s
BindingDB Entry DOI: 10.7270/Q2M32W6F
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50360241
PNG
(CHEMBL1928217)
Show SMILES CN(C)CCCNc1nc(NCCc2ccccc2F)nc(NCCc2ccccc2F)n1
Show InChI InChI=1S/C24H31F2N7/c1-33(2)17-7-14-27-22-30-23(28-15-12-18-8-3-5-10-20(18)25)32-24(31-22)29-16-13-19-9-4-6-11-21(19)26/h3-6,8-11H,7,12-17H2,1-2H3,(H3,27,28,29,30,31,32)
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n/an/a 450n/an/an/an/an/an/a



Institut de Qu£mica Avan£ada de Catalunya

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV1 expressed in Xenopus laevis oocytes assessed as blockage of capsaicin-induced current at holding potential -60 mV by...

J Med Chem 54: 7441-52 (2011)


Article DOI: 10.1021/jm200981s
BindingDB Entry DOI: 10.7270/Q2M32W6F
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50360263
PNG
(CHEMBL1928208)
Show SMILES CN(C)CCCNc1nc(NCCc2ccc(Cl)cc2)nc(NCCc2ccc(Cl)cc2)n1
Show InChI InChI=1S/C24H31Cl2N7/c1-33(2)17-3-14-27-22-30-23(28-15-12-18-4-8-20(25)9-5-18)32-24(31-22)29-16-13-19-6-10-21(26)11-7-19/h4-11H,3,12-17H2,1-2H3,(H3,27,28,29,30,31,32)
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n/an/a 500n/an/an/an/an/an/a



Institut de Qu£mica Avan£ada de Catalunya

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV1 expressed in Xenopus laevis oocytes assessed as blockage of capsaicin-induced current at holding potential -60 mV by...

J Med Chem 54: 7441-52 (2011)


Article DOI: 10.1021/jm200981s
BindingDB Entry DOI: 10.7270/Q2M32W6F
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50360260
PNG
(CHEMBL1928205)
Show SMILES [#7]\[#6](-[#7])=[#7]/[#6]-[#6]-[#6]-[#6]-[#7]-c1nc(-[#7]-[#6]-[#6]-c2ccc(F)cc2)nc(-[#7]-[#6]-[#6]-c2ccc(F)cc2)n1
Show InChI InChI=1S/C24H31F2N9/c25-19-7-3-17(4-8-19)11-15-31-23-33-22(30-14-2-1-13-29-21(27)28)34-24(35-23)32-16-12-18-5-9-20(26)10-6-18/h3-10H,1-2,11-16H2,(H4,27,28,29)(H3,30,31,32,33,34,35)
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Institut de Qu£mica Avan£ada de Catalunya

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV1 expressed in Xenopus laevis oocytes assessed as blockage of capsaicin-induced current at holding potential -60 mV by...

J Med Chem 54: 7441-52 (2011)


Article DOI: 10.1021/jm200981s
BindingDB Entry DOI: 10.7270/Q2M32W6F
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50360249
PNG
(CHEMBL1928343)
Show SMILES CN(C)CCCNc1nc(NCc2ccc(cc2)C(F)(F)F)nc(NCc2ccc(cc2)C(F)(F)F)n1
Show InChI InChI=1S/C24H27F6N7/c1-37(2)13-3-12-31-20-34-21(32-14-16-4-8-18(9-5-16)23(25,26)27)36-22(35-20)33-15-17-6-10-19(11-7-17)24(28,29)30/h4-11H,3,12-15H2,1-2H3,(H3,31,32,33,34,35,36)
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n/an/a 660n/an/an/an/an/an/a



Institut de Qu£mica Avan£ada de Catalunya

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV1 expressed in Xenopus laevis oocytes assessed as blockage of capsaicin-induced current at holding potential -60 mV by...

J Med Chem 54: 7441-52 (2011)


Article DOI: 10.1021/jm200981s
BindingDB Entry DOI: 10.7270/Q2M32W6F
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50360237
PNG
(CHEMBL1928213)
Show SMILES CN(C)CCCNc1nc(NCCc2ccccc2)nc(NCCc2ccccc2)n1
Show InChI InChI=1S/C24H33N7/c1-31(2)19-9-16-25-22-28-23(26-17-14-20-10-5-3-6-11-20)30-24(29-22)27-18-15-21-12-7-4-8-13-21/h3-8,10-13H,9,14-19H2,1-2H3,(H3,25,26,27,28,29,30)
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n/an/a 670n/an/an/an/an/an/a



Institut de Qu£mica Avan£ada de Catalunya

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV1 expressed in Xenopus laevis oocytes assessed as blockage of capsaicin-induced current at holding potential -60 mV by...

J Med Chem 54: 7441-52 (2011)


Article DOI: 10.1021/jm200981s
BindingDB Entry DOI: 10.7270/Q2M32W6F
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50360247
PNG
(CHEMBL1928341)
Show SMILES CN(C)CCCNc1nc(NCc2ccc(Cl)cc2Cl)nc(NCc2ccc(Cl)cc2Cl)n1
Show InChI InChI=1S/C22H25Cl4N7/c1-33(2)9-3-8-27-20-30-21(28-12-14-4-6-16(23)10-18(14)25)32-22(31-20)29-13-15-5-7-17(24)11-19(15)26/h4-7,10-11H,3,8-9,12-13H2,1-2H3,(H3,27,28,29,30,31,32)
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n/an/a 840n/an/an/an/an/an/a



Institut de Qu£mica Avan£ada de Catalunya

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV1 expressed in Xenopus laevis oocytes assessed as blockage of capsaicin-induced current at holding potential -60 mV by...

J Med Chem 54: 7441-52 (2011)


Article DOI: 10.1021/jm200981s
BindingDB Entry DOI: 10.7270/Q2M32W6F
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50360267
PNG
(CHEMBL1928212)
Show SMILES NCCN1CCN(CC1)c1nc(NCCc2ccc(Cl)cc2)nc(NCCc2ccc(Cl)cc2)n1
Show InChI InChI=1S/C25H32Cl2N8/c26-21-5-1-19(2-6-21)9-12-29-23-31-24(30-13-10-20-3-7-22(27)8-4-20)33-25(32-23)35-17-15-34(14-11-28)16-18-35/h1-8H,9-18,28H2,(H2,29,30,31,32,33)
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n/an/a 960n/an/an/an/an/an/a



Institut de Qu£mica Avan£ada de Catalunya

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV1 expressed in Xenopus laevis oocytes assessed as blockage of capsaicin-induced current at holding potential -60 mV by...

J Med Chem 54: 7441-52 (2011)


Article DOI: 10.1021/jm200981s
BindingDB Entry DOI: 10.7270/Q2M32W6F
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50360238
PNG
(CHEMBL1928214)
Show SMILES COc1ccc(CCNc2nc(NCCCN(C)C)nc(NCCc3ccc(OC)cc3)n2)cc1
Show InChI InChI=1S/C26H37N7O2/c1-33(2)19-5-16-27-24-30-25(28-17-14-20-6-10-22(34-3)11-7-20)32-26(31-24)29-18-15-21-8-12-23(35-4)13-9-21/h6-13H,5,14-19H2,1-4H3,(H3,27,28,29,30,31,32)
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n/an/a 970n/an/an/an/an/an/a



Institut de Qu£mica Avan£ada de Catalunya

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV1 expressed in Xenopus laevis oocytes assessed as blockage of capsaicin-induced current at holding potential -60 mV by...

J Med Chem 54: 7441-52 (2011)


Article DOI: 10.1021/jm200981s
BindingDB Entry DOI: 10.7270/Q2M32W6F
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50360264
PNG
(CHEMBL1928209)
Show SMILES CN1CCCC1CCNc1nc(NCCc2ccc(Cl)cc2)nc(NCCc2ccc(Cl)cc2)n1
Show InChI InChI=1S/C26H33Cl2N7/c1-35-18-2-3-23(35)14-17-31-26-33-24(29-15-12-19-4-8-21(27)9-5-19)32-25(34-26)30-16-13-20-6-10-22(28)11-7-20/h4-11,23H,2-3,12-18H2,1H3,(H3,29,30,31,32,33,34)
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n/an/a 1.20E+3n/an/an/an/an/an/a



Institut de Qu£mica Avan£ada de Catalunya

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV1 expressed in Xenopus laevis oocytes assessed as blockage of capsaicin-induced current at holding potential -60 mV by...

J Med Chem 54: 7441-52 (2011)


Article DOI: 10.1021/jm200981s
BindingDB Entry DOI: 10.7270/Q2M32W6F
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50360239
PNG
(CHEMBL1928215)
Show SMILES CN(C)CCCNc1nc(NCCc2ccc(Cl)cc2Cl)nc(NCCc2ccc(Cl)cc2Cl)n1
Show InChI InChI=1S/C24H29Cl4N7/c1-35(2)13-3-10-29-22-32-23(30-11-8-16-4-6-18(25)14-20(16)27)34-24(33-22)31-12-9-17-5-7-19(26)15-21(17)28/h4-7,14-15H,3,8-13H2,1-2H3,(H3,29,30,31,32,33,34)
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n/an/a 1.21E+3n/an/an/an/an/an/a



Institut de Qu£mica Avan£ada de Catalunya

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV1 expressed in Xenopus laevis oocytes assessed as blockage of capsaicin-induced current at holding potential -60 mV by...

J Med Chem 54: 7441-52 (2011)


Article DOI: 10.1021/jm200981s
BindingDB Entry DOI: 10.7270/Q2M32W6F
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50360240
PNG
(CHEMBL1928216)
Show SMILES CN(C)CCCNc1nc(NCCc2ccc(cc2)[N+]([O-])=O)nc(NCCc2ccc(cc2)[N+]([O-])=O)n1
Show InChI InChI=1S/C24H31N9O4/c1-31(2)17-3-14-25-22-28-23(26-15-12-18-4-8-20(9-5-18)32(34)35)30-24(29-22)27-16-13-19-6-10-21(11-7-19)33(36)37/h4-11H,3,12-17H2,1-2H3,(H3,25,26,27,28,29,30)
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n/an/a 1.63E+3n/an/an/an/an/an/a



Institut de Qu£mica Avan£ada de Catalunya

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV1 expressed in Xenopus laevis oocytes assessed as blockage of capsaicin-induced current at holding potential -60 mV by...

J Med Chem 54: 7441-52 (2011)


Article DOI: 10.1021/jm200981s
BindingDB Entry DOI: 10.7270/Q2M32W6F
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50360243
PNG
(CHEMBL1928219)
Show SMILES CN(C)CCCNc1nc(NCCc2c[nH]c3ccccc23)nc(NCCc2c[nH]c3ccccc23)n1
Show InChI InChI=1S/C28H35N9/c1-37(2)17-7-14-29-26-34-27(30-15-12-20-18-32-24-10-5-3-8-22(20)24)36-28(35-26)31-16-13-21-19-33-25-11-6-4-9-23(21)25/h3-6,8-11,18-19,32-33H,7,12-17H2,1-2H3,(H3,29,30,31,34,35,36)
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n/an/a 2.33E+3n/an/an/an/an/an/a



Institut de Qu£mica Avan£ada de Catalunya

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV1 expressed in Xenopus laevis oocytes assessed as blockage of capsaicin-induced current at holding potential -60 mV by...

J Med Chem 54: 7441-52 (2011)


Article DOI: 10.1021/jm200981s
BindingDB Entry DOI: 10.7270/Q2M32W6F
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50360245
PNG
(CHEMBL1928339)
Show SMILES CN(C)CCCNc1nc(NCc2ccc(Cl)cc2)nc(NCc2ccc(Cl)cc2)n1
Show InChI InChI=1S/C22H27Cl2N7/c1-31(2)13-3-12-25-20-28-21(26-14-16-4-8-18(23)9-5-16)30-22(29-20)27-15-17-6-10-19(24)11-7-17/h4-11H,3,12-15H2,1-2H3,(H3,25,26,27,28,29,30)
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n/an/a 2.62E+3n/an/an/an/an/an/a



Institut de Qu£mica Avan£ada de Catalunya

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV1 expressed in Xenopus laevis oocytes assessed as blockage of capsaicin-induced current at holding potential -60 mV by...

J Med Chem 54: 7441-52 (2011)


Article DOI: 10.1021/jm200981s
BindingDB Entry DOI: 10.7270/Q2M32W6F
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50360246
PNG
(CHEMBL1928340)
Show SMILES CN(C)CCCNc1nc(NCc2ccc(F)cc2)nc(NCc2ccc(F)cc2)n1
Show InChI InChI=1S/C22H27F2N7/c1-31(2)13-3-12-25-20-28-21(26-14-16-4-8-18(23)9-5-16)30-22(29-20)27-15-17-6-10-19(24)11-7-17/h4-11H,3,12-15H2,1-2H3,(H3,25,26,27,28,29,30)
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n/an/a 3.06E+3n/an/an/an/an/an/a



Institut de Qu£mica Avan£ada de Catalunya

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV1 expressed in Xenopus laevis oocytes assessed as blockage of capsaicin-induced current at holding potential -60 mV by...

J Med Chem 54: 7441-52 (2011)


Article DOI: 10.1021/jm200981s
BindingDB Entry DOI: 10.7270/Q2M32W6F
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50360248
PNG
(CHEMBL1928342)
Show SMILES CN(C)CCCNc1nc(NCc2ccc(F)cc2F)nc(NCc2ccc(F)cc2F)n1
Show InChI InChI=1S/C22H25F4N7/c1-33(2)9-3-8-27-20-30-21(28-12-14-4-6-16(23)10-18(14)25)32-22(31-20)29-13-15-5-7-17(24)11-19(15)26/h4-7,10-11H,3,8-9,12-13H2,1-2H3,(H3,27,28,29,30,31,32)
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n/an/a 3.30E+3n/an/an/an/an/an/a



Institut de Qu£mica Avan£ada de Catalunya

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV1 expressed in Xenopus laevis oocytes assessed as blockage of capsaicin-induced current at holding potential -60 mV by...

J Med Chem 54: 7441-52 (2011)


Article DOI: 10.1021/jm200981s
BindingDB Entry DOI: 10.7270/Q2M32W6F
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50360250
PNG
(CHEMBL1928344)
Show SMILES CN(C)CCCNc1nc(NCc2ccc3OCOc3c2)nc(NCc2ccc3OCOc3c2)n1
Show InChI InChI=1S/C24H29N7O4/c1-31(2)9-3-8-25-22-28-23(26-12-16-4-6-18-20(10-16)34-14-32-18)30-24(29-22)27-13-17-5-7-19-21(11-17)35-15-33-19/h4-7,10-11H,3,8-9,12-15H2,1-2H3,(H3,25,26,27,28,29,30)
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n/an/a 4.98E+3n/an/an/an/an/an/a



Institut de Qu£mica Avan£ada de Catalunya

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV1 expressed in Xenopus laevis oocytes assessed as blockage of capsaicin-induced current at holding potential -60 mV by...

J Med Chem 54: 7441-52 (2011)


Article DOI: 10.1021/jm200981s
BindingDB Entry DOI: 10.7270/Q2M32W6F
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50360258
PNG
(CHEMBL1928203)
Show SMILES CN(C)CCCOc1nc(NCCc2ccc(F)cc2)nc(NCCc2ccc(F)cc2)n1
Show InChI InChI=1S/C24H30F2N6O/c1-32(2)16-3-17-33-24-30-22(27-14-12-18-4-8-20(25)9-5-18)29-23(31-24)28-15-13-19-6-10-21(26)11-7-19/h4-11H,3,12-17H2,1-2H3,(H2,27,28,29,30,31)
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n/an/a 6.14E+3n/an/an/an/an/an/a



Institut de Qu£mica Avan£ada de Catalunya

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV1 expressed in Xenopus laevis oocytes assessed as blockage of capsaicin-induced current at holding potential -60 mV by...

J Med Chem 54: 7441-52 (2011)


Article DOI: 10.1021/jm200981s
BindingDB Entry DOI: 10.7270/Q2M32W6F
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50360266
PNG
(CHEMBL1928211)
Show SMILES CN1CCN(CC1)Nc1nc(NCCc2ccc(Cl)cc2)nc(NCCc2ccc(Cl)cc2)n1
Show InChI InChI=1S/C24H30Cl2N8/c1-33-14-16-34(17-15-33)32-24-30-22(27-12-10-18-2-6-20(25)7-3-18)29-23(31-24)28-13-11-19-4-8-21(26)9-5-19/h2-9H,10-17H2,1H3,(H3,27,28,29,30,31,32)
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n/an/a 6.40E+3n/an/an/an/an/an/a



Institut de Qu£mica Avan£ada de Catalunya

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV1 expressed in Xenopus laevis oocytes assessed as blockage of capsaicin-induced current at holding potential -60 mV by...

J Med Chem 54: 7441-52 (2011)


Article DOI: 10.1021/jm200981s
BindingDB Entry DOI: 10.7270/Q2M32W6F
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50360265
PNG
(CHEMBL1928210)
Show SMILES CN(C)CCNc1nc(NCCc2ccc(Cl)cc2)nc(NCCc2ccc(Cl)cc2)n1
Show InChI InChI=1S/C23H29Cl2N7/c1-32(2)16-15-28-23-30-21(26-13-11-17-3-7-19(24)8-4-17)29-22(31-23)27-14-12-18-5-9-20(25)10-6-18/h3-10H,11-16H2,1-2H3,(H3,26,27,28,29,30,31)
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n/an/a 6.70E+3n/an/an/an/an/an/a



Institut de Qu£mica Avan£ada de Catalunya

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV1 expressed in Xenopus laevis oocytes assessed as blockage of capsaicin-induced current at holding potential -60 mV by...

J Med Chem 54: 7441-52 (2011)


Article DOI: 10.1021/jm200981s
BindingDB Entry DOI: 10.7270/Q2M32W6F
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50360253
PNG
(CHEMBL1928347)
Show SMILES CN(C)CCCNc1nc(nc(n1)N1CCc2[nH]c3ccccc3c2C1)N1CCc2[nH]c3ccccc3c2C1
Show InChI InChI=1S/C30H35N9/c1-37(2)15-7-14-31-28-34-29(38-16-12-26-22(18-38)20-8-3-5-10-24(20)32-26)36-30(35-28)39-17-13-27-23(19-39)21-9-4-6-11-25(21)33-27/h3-6,8-11,32-33H,7,12-19H2,1-2H3,(H,31,34,35,36)
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n/an/a 7.00E+3n/an/an/an/an/an/a



Institut de Qu£mica Avan£ada de Catalunya

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV1 expressed in Xenopus laevis oocytes assessed as blockage of capsaicin-induced current at holding potential -60 mV by...

J Med Chem 54: 7441-52 (2011)


Article DOI: 10.1021/jm200981s
BindingDB Entry DOI: 10.7270/Q2M32W6F
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50360259
PNG
(CHEMBL1928204)
Show SMILES CN(C)CCOCCNc1nc(NCCc2ccc(F)cc2)nc(NCCc2ccc(F)cc2)n1
Show InChI InChI=1S/C25H33F2N7O/c1-34(2)16-18-35-17-15-30-25-32-23(28-13-11-19-3-7-21(26)8-4-19)31-24(33-25)29-14-12-20-5-9-22(27)10-6-20/h3-10H,11-18H2,1-2H3,(H3,28,29,30,31,32,33)
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n/an/a 7.05E+3n/an/an/an/an/an/a



Institut de Qu£mica Avan£ada de Catalunya

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV1 expressed in Xenopus laevis oocytes assessed as blockage of capsaicin-induced current at holding potential -60 mV by...

J Med Chem 54: 7441-52 (2011)


Article DOI: 10.1021/jm200981s
BindingDB Entry DOI: 10.7270/Q2M32W6F
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50360262
PNG
(CHEMBL1928207)
Show SMILES CN(C)CCN1CCN(CC1)c1nc(NCCc2ccc(F)cc2)nc(NCCc2ccc(F)cc2)n1
Show InChI InChI=1S/C27H36F2N8/c1-35(2)15-16-36-17-19-37(20-18-36)27-33-25(30-13-11-21-3-7-23(28)8-4-21)32-26(34-27)31-14-12-22-5-9-24(29)10-6-22/h3-10H,11-20H2,1-2H3,(H2,30,31,32,33,34)
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n/an/a 1.86E+4n/an/an/an/an/an/a



Institut de Qu£mica Avan£ada de Catalunya

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV1 expressed in Xenopus laevis oocytes assessed as blockage of capsaicin-induced current at holding potential -60 mV by...

J Med Chem 54: 7441-52 (2011)


Article DOI: 10.1021/jm200981s
BindingDB Entry DOI: 10.7270/Q2M32W6F
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50360252
PNG
(CHEMBL1928346)
Show SMILES CN(C)CCCNc1nc(nc(n1)N1CCN(CC1)C(c1ccc(F)cc1)c1ccc(F)cc1)N1CCN(CC1)C(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C42H47F4N9/c1-51(2)21-3-20-47-40-48-41(54-26-22-52(23-27-54)38(30-4-12-34(43)13-5-30)31-6-14-35(44)15-7-31)50-42(49-40)55-28-24-53(25-29-55)39(32-8-16-36(45)17-9-32)33-10-18-37(46)19-11-33/h4-19,38-39H,3,20-29H2,1-2H3,(H,47,48,49,50)
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n/an/a 5.64E+4n/an/an/an/an/an/a



Institut de Qu£mica Avan£ada de Catalunya

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV1 expressed in Xenopus laevis oocytes assessed as blockage of capsaicin-induced current at holding potential -60 mV by...

J Med Chem 54: 7441-52 (2011)


Article DOI: 10.1021/jm200981s
BindingDB Entry DOI: 10.7270/Q2M32W6F
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50360251
PNG
(CHEMBL1928345)
Show SMILES COC(=O)c1ccc(CNc2nc(NCCCN(C)C)nc(NCc3ccc(cc3)C(=O)OC)n2)cc1
Show InChI InChI=1S/C26H33N7O4/c1-33(2)15-5-14-27-24-30-25(28-16-18-6-10-20(11-7-18)22(34)36-3)32-26(31-24)29-17-19-8-12-21(13-9-19)23(35)37-4/h6-13H,5,14-17H2,1-4H3,(H3,27,28,29,30,31,32)
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n/an/a 6.91E+4n/an/an/an/an/an/a



Institut de Qu£mica Avan£ada de Catalunya

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV1 expressed in Xenopus laevis oocytes assessed as blockage of capsaicin-induced current at holding potential -60 mV by...

J Med Chem 54: 7441-52 (2011)


Article DOI: 10.1021/jm200981s
BindingDB Entry DOI: 10.7270/Q2M32W6F
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50360261
PNG
(CHEMBL1928206)
Show SMILES CN1CCC(CC1)N1CCN(CC1)c1nc(NCCc2ccc(F)cc2)nc(NCCc2ccc(F)cc2)n1
Show InChI InChI=1S/C29H38F2N8/c1-37-16-12-26(13-17-37)38-18-20-39(21-19-38)29-35-27(32-14-10-22-2-6-24(30)7-3-22)34-28(36-29)33-15-11-23-4-8-25(31)9-5-23/h2-9,26H,10-21H2,1H3,(H2,32,33,34,35,36)
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n/an/a 7.09E+4n/an/an/an/an/an/a



Institut de Qu£mica Avan£ada de Catalunya

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV1 expressed in Xenopus laevis oocytes assessed as blockage of capsaicin-induced current at holding potential -60 mV by...

J Med Chem 54: 7441-52 (2011)


Article DOI: 10.1021/jm200981s
BindingDB Entry DOI: 10.7270/Q2M32W6F
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50360254
PNG
(CHEMBL1928348)
Show SMILES CN(C)CCCNc1nc(NCc2ccc(cc2)C(O)=O)nc(NCc2ccc(cc2)C(O)=O)n1
Show InChI InChI=1S/C24H29N7O4/c1-31(2)13-3-12-25-22-28-23(26-14-16-4-8-18(9-5-16)20(32)33)30-24(29-22)27-15-17-6-10-19(11-7-17)21(34)35/h4-11H,3,12-15H2,1-2H3,(H,32,33)(H,34,35)(H3,25,26,27,28,29,30)
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n/an/a 1.78E+5n/an/an/an/an/an/a



Institut de Qu£mica Avan£ada de Catalunya

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV1 expressed in Xenopus laevis oocytes assessed as blockage of capsaicin-induced current at holding potential -60 mV by...

J Med Chem 54: 7441-52 (2011)


Article DOI: 10.1021/jm200981s
BindingDB Entry DOI: 10.7270/Q2M32W6F
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50360244
PNG
(CHEMBL1928338)
Show SMILES CN(C)CCCNc1nc(NCCC2=CCCCC2)nc(NCCC2=CCCCC2)n1 |t:13,25|
Show InChI InChI=1S/C24H41N7/c1-31(2)19-9-16-25-22-28-23(26-17-14-20-10-5-3-6-11-20)30-24(29-22)27-18-15-21-12-7-4-8-13-21/h10,12H,3-9,11,13-19H2,1-2H3,(H3,25,26,27,28,29,30)
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n/an/a 2.18E+5n/an/an/an/an/an/a



Institut de Qu£mica Avan£ada de Catalunya

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV1 expressed in Xenopus laevis oocytes assessed as blockage of capsaicin-induced current at holding potential -60 mV by...

J Med Chem 54: 7441-52 (2011)


Article DOI: 10.1021/jm200981s
BindingDB Entry DOI: 10.7270/Q2M32W6F
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50360255
PNG
(CHEMBL1928349)
Show SMILES CCCCNc1nc(NCc2ccc(cc2)C(O)=O)nc(NCc2ccc(cc2)C(O)=O)n1
Show InChI InChI=1S/C23H26N6O4/c1-2-3-12-24-21-27-22(25-13-15-4-8-17(9-5-15)19(30)31)29-23(28-21)26-14-16-6-10-18(11-7-16)20(32)33/h4-11H,2-3,12-14H2,1H3,(H,30,31)(H,32,33)(H3,24,25,26,27,28,29)
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n/an/a 2.29E+5n/an/an/an/an/an/a



Institut de Qu£mica Avan£ada de Catalunya

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV1 expressed in Xenopus laevis oocytes assessed as blockage of capsaicin-induced current at holding potential -60 mV by...

J Med Chem 54: 7441-52 (2011)


Article DOI: 10.1021/jm200981s
BindingDB Entry DOI: 10.7270/Q2M32W6F
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%