Found 5 hits of Enzyme Inhibition Constant Data Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1
(Homo sapiens (Human)) | BDBM50356009
(CHEMBL1911368)Show SMILES COc1cc2c(CNS(=O)(=O)C(F)(F)F)cnc(C(=O)c3cccc(OC(C)C)c3)c2cc1OC Show InChI InChI=1S/C23H23F3N2O6S/c1-13(2)34-16-7-5-6-14(8-16)22(29)21-18-10-20(33-4)19(32-3)9-17(18)15(11-27-21)12-28-35(30,31)23(24,25)26/h5-11,13,28H,12H2,1-4H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| 300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc.
Curated by ChEMBL
| Assay Description Competitive inhibition of GFAT in presence of glutamine |
Bioorg Med Chem Lett 21: 6264-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.09.009 BindingDB Entry DOI: 10.7270/Q21J9B6P |
More data for this Ligand-Target Pair | |
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1
(Homo sapiens (Human)) | BDBM50356009
(CHEMBL1911368)Show SMILES COc1cc2c(CNS(=O)(=O)C(F)(F)F)cnc(C(=O)c3cccc(OC(C)C)c3)c2cc1OC Show InChI InChI=1S/C23H23F3N2O6S/c1-13(2)34-16-7-5-6-14(8-16)22(29)21-18-10-20(33-4)19(32-3)9-17(18)15(11-27-21)12-28-35(30,31)23(24,25)26/h5-11,13,28H,12H2,1-4H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| 300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc.
Curated by ChEMBL
| Assay Description Noncompetitive inhibition of GFAT in presence of fructose-6-phosphate |
Bioorg Med Chem Lett 21: 6264-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.09.009 BindingDB Entry DOI: 10.7270/Q21J9B6P |
More data for this Ligand-Target Pair | |
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1
(Homo sapiens (Human)) | BDBM50356010
(CHEMBL1911372)Show InChI InChI=1S/C5H9BrN2O3/c6-1-4(9)8-2-3(7)5(10)11/h3H,1-2,7H2,(H,8,9)(H,10,11)/t3-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc.
Curated by ChEMBL
| Assay Description Irreversible inhibition of GFAT |
Bioorg Med Chem Lett 21: 6264-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.09.009 BindingDB Entry DOI: 10.7270/Q21J9B6P |
More data for this Ligand-Target Pair | |
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1
(Homo sapiens (Human)) | BDBM50356011
(CHEMBL1911373)Show InChI InChI=1S/C8H12N2O5/c1-15-7(12)3-2-6(11)10-4-5(9)8(13)14/h2-3,5H,4,9H2,1H3,(H,10,11)(H,13,14)/b3-2+/t5-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc.
Curated by ChEMBL
| Assay Description Irreversible inhibition of GFAT |
Bioorg Med Chem Lett 21: 6264-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.09.009 BindingDB Entry DOI: 10.7270/Q21J9B6P |
More data for this Ligand-Target Pair | |
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1
(Homo sapiens (Human)) | BDBM50356012
(AAPTAMINE)Show InChI InChI=1S/C13H12N2O2/c1-16-10-7-8-3-5-14-9-4-6-15-12(11(8)9)13(10)17-2/h3-7,15H,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.20E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc.
Curated by ChEMBL
| Assay Description Inhibition of GFAT using N-acetylglucosamine 6-phosphate as substrate |
Bioorg Med Chem Lett 21: 6264-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.09.009 BindingDB Entry DOI: 10.7270/Q21J9B6P |
More data for this Ligand-Target Pair | |