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PubMed code 22041058

Compile data set for download or QSAR
Found 44 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Coagulation factor X


(Homo sapiens (Human))
BDBM50358883
PNG
(CHEMBL1923468)
Show SMILES Clc1ccc2cc(ccc2c1)S(=O)(=O)N[C@H]1CCCN(CC(=O)N2C[C@@H]3C[C@H](C2)c2cccc(=O)n2C3)C1=O |r|
Show InChI InChI=1S/C28H29ClN4O5S/c29-22-8-6-20-13-23(9-7-19(20)12-22)39(37,38)30-24-3-2-10-31(28(24)36)17-27(35)32-14-18-11-21(16-32)25-4-1-5-26(34)33(25)15-18/h1,4-9,12-13,18,21,24,30H,2-3,10-11,14-17H2/t18-,21+,24-/m0/s1
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4.71n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Inhibition of human factor 10a by Michaelis Menten equation analysis


Bioorg Med Chem Lett 21: 7516-21 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.098
BindingDB Entry DOI: 10.7270/Q2MK6DBS
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tissue-type plasminogen activator


(Homo sapiens (Human))
BDBM50358883
PNG
(CHEMBL1923468)
Show SMILES Clc1ccc2cc(ccc2c1)S(=O)(=O)N[C@H]1CCCN(CC(=O)N2C[C@@H]3C[C@H](C2)c2cccc(=O)n2C3)C1=O |r|
Show InChI InChI=1S/C28H29ClN4O5S/c29-22-8-6-20-13-23(9-7-19(20)12-22)39(37,38)30-24-3-2-10-31(28(24)36)17-27(35)32-14-18-11-21(16-32)25-4-1-5-26(34)33(25)15-18/h1,4-9,12-13,18,21,24,30H,2-3,10-11,14-17H2/t18-,21+,24-/m0/s1
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1.28E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Inhibition of human TPA by Michaelis Menten equation analysis


Bioorg Med Chem Lett 21: 7516-21 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.098
BindingDB Entry DOI: 10.7270/Q2MK6DBS
More data for this
Ligand-Target Pair
Thrombin and coagulation factor X


(Homo sapiens (Human))
BDBM50358883
PNG
(CHEMBL1923468)
Show SMILES Clc1ccc2cc(ccc2c1)S(=O)(=O)N[C@H]1CCCN(CC(=O)N2C[C@@H]3C[C@H](C2)c2cccc(=O)n2C3)C1=O |r|
Show InChI InChI=1S/C28H29ClN4O5S/c29-22-8-6-20-13-23(9-7-19(20)12-22)39(37,38)30-24-3-2-10-31(28(24)36)17-27(35)32-14-18-11-21(16-32)25-4-1-5-26(34)33(25)15-18/h1,4-9,12-13,18,21,24,30H,2-3,10-11,14-17H2/t18-,21+,24-/m0/s1
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3.28E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Inhibition of human alpha-thrombin by Michaelis Menten equation analysis


Bioorg Med Chem Lett 21: 7516-21 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.098
BindingDB Entry DOI: 10.7270/Q2MK6DBS
More data for this
Ligand-Target Pair
Coagulation factor VII


(Homo sapiens (Human))
BDBM50358883
PNG
(CHEMBL1923468)
Show SMILES Clc1ccc2cc(ccc2c1)S(=O)(=O)N[C@H]1CCCN(CC(=O)N2C[C@@H]3C[C@H](C2)c2cccc(=O)n2C3)C1=O |r|
Show InChI InChI=1S/C28H29ClN4O5S/c29-22-8-6-20-13-23(9-7-19(20)12-22)39(37,38)30-24-3-2-10-31(28(24)36)17-27(35)32-14-18-11-21(16-32)25-4-1-5-26(34)33(25)15-18/h1,4-9,12-13,18,21,24,30H,2-3,10-11,14-17H2/t18-,21+,24-/m0/s1
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3.68E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Inhibition of human factor 7a by Michaelis Menten equation analysis


Bioorg Med Chem Lett 21: 7516-21 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.098
BindingDB Entry DOI: 10.7270/Q2MK6DBS
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))
BDBM50358883
PNG
(CHEMBL1923468)
Show SMILES Clc1ccc2cc(ccc2c1)S(=O)(=O)N[C@H]1CCCN(CC(=O)N2C[C@@H]3C[C@H](C2)c2cccc(=O)n2C3)C1=O |r|
Show InChI InChI=1S/C28H29ClN4O5S/c29-22-8-6-20-13-23(9-7-19(20)12-22)39(37,38)30-24-3-2-10-31(28(24)36)17-27(35)32-14-18-11-21(16-32)25-4-1-5-26(34)33(25)15-18/h1,4-9,12-13,18,21,24,30H,2-3,10-11,14-17H2/t18-,21+,24-/m0/s1
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1.33E+4n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Inhibition of human factor 11a by Michaelis Menten equation analysis


Bioorg Med Chem Lett 21: 7516-21 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.098
BindingDB Entry DOI: 10.7270/Q2MK6DBS
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50358883
PNG
(CHEMBL1923468)
Show SMILES Clc1ccc2cc(ccc2c1)S(=O)(=O)N[C@H]1CCCN(CC(=O)N2C[C@@H]3C[C@H](C2)c2cccc(=O)n2C3)C1=O |r|
Show InChI InChI=1S/C28H29ClN4O5S/c29-22-8-6-20-13-23(9-7-19(20)12-22)39(37,38)30-24-3-2-10-31(28(24)36)17-27(35)32-14-18-11-21(16-32)25-4-1-5-26(34)33(25)15-18/h1,4-9,12-13,18,21,24,30H,2-3,10-11,14-17H2/t18-,21+,24-/m0/s1
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1.51E+4n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Inhibition of human u-PA by Michaelis Menten equation analysis


Bioorg Med Chem Lett 21: 7516-21 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.098
BindingDB Entry DOI: 10.7270/Q2MK6DBS
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (Human))
BDBM50358883
PNG
(CHEMBL1923468)
Show SMILES Clc1ccc2cc(ccc2c1)S(=O)(=O)N[C@H]1CCCN(CC(=O)N2C[C@@H]3C[C@H](C2)c2cccc(=O)n2C3)C1=O |r|
Show InChI InChI=1S/C28H29ClN4O5S/c29-22-8-6-20-13-23(9-7-19(20)12-22)39(37,38)30-24-3-2-10-31(28(24)36)17-27(35)32-14-18-11-21(16-32)25-4-1-5-26(34)33(25)15-18/h1,4-9,12-13,18,21,24,30H,2-3,10-11,14-17H2/t18-,21+,24-/m0/s1
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1.58E+4n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Inhibition of human plasmin by Michaelis Menten equation analysis


Bioorg Med Chem Lett 21: 7516-21 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.098
BindingDB Entry DOI: 10.7270/Q2MK6DBS
More data for this
Ligand-Target Pair
Vitamin K-dependent protein C


(Homo sapiens (Human))
BDBM50358883
PNG
(CHEMBL1923468)
Show SMILES Clc1ccc2cc(ccc2c1)S(=O)(=O)N[C@H]1CCCN(CC(=O)N2C[C@@H]3C[C@H](C2)c2cccc(=O)n2C3)C1=O |r|
Show InChI InChI=1S/C28H29ClN4O5S/c29-22-8-6-20-13-23(9-7-19(20)12-22)39(37,38)30-24-3-2-10-31(28(24)36)17-27(35)32-14-18-11-21(16-32)25-4-1-5-26(34)33(25)15-18/h1,4-9,12-13,18,21,24,30H,2-3,10-11,14-17H2/t18-,21+,24-/m0/s1
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2.25E+4n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Inhibition of human activated protein C by Michaelis Menten equation analysis


Bioorg Med Chem Lett 21: 7516-21 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.098
BindingDB Entry DOI: 10.7270/Q2MK6DBS
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50328724
PNG
((S)-N2,N2-dimethyl-N5-((2-methylbenzofuran-5-ylami...)
Show SMILES CN(C)C(=O)c1ccc(cn1)C(=O)NC(Nc1ccc2oc(C)cc2c1)=N[C@H]1CCCCN(CC(=O)N2CCCC2)C1=O |r,w:14.14|
Show InChI InChI=1S/C31H37N7O5/c1-20-16-22-17-23(10-12-26(22)43-20)33-31(35-28(40)21-9-11-24(32-18-21)29(41)36(2)3)34-25-8-4-5-15-38(30(25)42)19-27(39)37-13-6-7-14-37/h9-12,16-18,25H,4-8,13-15,19H2,1-3H3,(H2,33,34,35,40)/t25-/m0/s1
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n/an/a 7n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Inhibition of human factor 10a using phenyl-Ile-Glu-Gly-Arg-pNA as substrate preincubated for 3 mins prior to substrate addition by spectrophotometry


Bioorg Med Chem Lett 21: 7516-21 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.098
BindingDB Entry DOI: 10.7270/Q2MK6DBS
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50358889
PNG
(CHEMBL1923563)
Show SMILES Nc1[nH]ncc1C(=O)N1CC2CC(CN(C2)C(=O)CN2CCC[C@H](NS(=O)(=O)c3ccc4cc(Cl)ccc4c3)C2=O)C1 |r|
Show InChI InChI=1S/C28H32ClN7O5S/c29-21-5-3-20-10-22(6-4-19(20)9-21)42(40,41)33-24-2-1-7-34(28(24)39)16-25(37)35-12-17-8-18(13-35)15-36(14-17)27(38)23-11-31-32-26(23)30/h3-6,9-11,17-18,24,33H,1-2,7-8,12-16H2,(H3,30,31,32)/t17?,18?,24-/m0/s1
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n/an/a 7n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Inhibition of human factor 10a using phenyl-Ile-Glu-Gly-Arg-pNA as substrate preincubated for 3 mins prior to substrate addition by spectrophotometry


Bioorg Med Chem Lett 21: 7516-21 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.098
BindingDB Entry DOI: 10.7270/Q2MK6DBS
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50358887
PNG
(CHEMBL1923561)
Show SMILES CS(=O)(=O)N1CC2CC(CN(C2)C(=O)CN2CCC[C@H](NS(=O)(=O)c3ccc4cc(Cl)ccc4c3)C2=O)C1 |r|
Show InChI InChI=1S/C25H31ClN4O6S2/c1-37(33,34)30-14-17-9-18(15-30)13-29(12-17)24(31)16-28-8-2-3-23(25(28)32)27-38(35,36)22-7-5-19-10-21(26)6-4-20(19)11-22/h4-7,10-11,17-18,23,27H,2-3,8-9,12-16H2,1H3/t17?,18?,23-/m0/s1
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n/an/a 10n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Inhibition of human factor 10a using phenyl-Ile-Glu-Gly-Arg-pNA as substrate preincubated for 3 mins prior to substrate addition by spectrophotometry


Bioorg Med Chem Lett 21: 7516-21 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.098
BindingDB Entry DOI: 10.7270/Q2MK6DBS
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50358884
PNG
(CHEMBL1923469)
Show SMILES CC(=O)N1CC2CC(C1)CN(C2)C(=O)CN1CCC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O |r|
Show InChI InChI=1S/C26H31ClN4O5S/c1-17(32)30-12-18-9-19(13-30)15-31(14-18)25(33)16-29-8-2-3-24(26(29)34)28-37(35,36)23-7-5-20-10-22(27)6-4-21(20)11-23/h4-7,10-11,18-19,24,28H,2-3,8-9,12-16H2,1H3/t18?,19?,24-/m0/s1
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n/an/a 11n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Inhibition of human factor 10a using phenyl-Ile-Glu-Gly-Arg-pNA as substrate preincubated for 3 mins prior to substrate addition by spectrophotometry


Bioorg Med Chem Lett 21: 7516-21 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.098
BindingDB Entry DOI: 10.7270/Q2MK6DBS
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50358883
PNG
(CHEMBL1923468)
Show SMILES Clc1ccc2cc(ccc2c1)S(=O)(=O)N[C@H]1CCCN(CC(=O)N2C[C@@H]3C[C@H](C2)c2cccc(=O)n2C3)C1=O |r|
Show InChI InChI=1S/C28H29ClN4O5S/c29-22-8-6-20-13-23(9-7-19(20)12-22)39(37,38)30-24-3-2-10-31(28(24)36)17-27(35)32-14-18-11-21(16-32)25-4-1-5-26(34)33(25)15-18/h1,4-9,12-13,18,21,24,30H,2-3,10-11,14-17H2/t18-,21+,24-/m0/s1
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n/an/a 13n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Inhibition of human factor 10a using phenyl-Ile-Glu-Gly-Arg-pNA as substrate preincubated for 3 mins prior to substrate addition by spectrophotometry


Bioorg Med Chem Lett 21: 7516-21 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.098
BindingDB Entry DOI: 10.7270/Q2MK6DBS
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Coagulation factor X


(Homo sapiens (Human))
BDBM50358888
PNG
(CHEMBL1923562)
Show SMILES Clc1ccc2cc(ccc2c1)S(=O)(=O)N[C@H]1CCCN(CC(=O)N2CC3CC(C2)CN(C3)C(=O)C2CCNCC2)C1=O |r|
Show InChI InChI=1S/C30H38ClN5O5S/c31-25-5-3-24-14-26(6-4-23(24)13-25)42(40,41)33-27-2-1-11-34(30(27)39)19-28(37)35-15-20-12-21(16-35)18-36(17-20)29(38)22-7-9-32-10-8-22/h3-6,13-14,20-22,27,32-33H,1-2,7-12,15-19H2/t20?,21?,27-/m0/s1
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n/an/a 13n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Inhibition of human factor 10a using phenyl-Ile-Glu-Gly-Arg-pNA as substrate preincubated for 3 mins prior to substrate addition by spectrophotometry


Bioorg Med Chem Lett 21: 7516-21 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.098
BindingDB Entry DOI: 10.7270/Q2MK6DBS
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50358885
PNG
(CHEMBL1923470)
Show SMILES NC(=O)N1CC2CC(C1)CN(C2)C(=O)CN1CCC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O |r|
Show InChI InChI=1S/C25H30ClN5O5S/c26-20-5-3-19-10-21(6-4-18(19)9-20)37(35,36)28-22-2-1-7-29(24(22)33)15-23(32)30-11-16-8-17(12-30)14-31(13-16)25(27)34/h3-6,9-10,16-17,22,28H,1-2,7-8,11-15H2,(H2,27,34)/t16?,17?,22-/m0/s1
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n/an/a 14n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Inhibition of human factor 10a using phenyl-Ile-Glu-Gly-Arg-pNA as substrate preincubated for 3 mins prior to substrate addition by spectrophotometry


Bioorg Med Chem Lett 21: 7516-21 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.098
BindingDB Entry DOI: 10.7270/Q2MK6DBS
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50358871
PNG
(CHEMBL1923457)
Show SMILES Clc1ccc2cc(sc2n1)S(=O)(=O)N[C@H]1CCCN(CC(=O)N2CCCC2)C1=O |r|
Show InChI InChI=1S/C18H21ClN4O4S2/c19-14-6-5-12-10-16(28-17(12)20-14)29(26,27)21-13-4-3-9-23(18(13)25)11-15(24)22-7-1-2-8-22/h5-6,10,13,21H,1-4,7-9,11H2/t13-/m0/s1
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n/an/a 14n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Inhibition of human factor 10a using phenyl-Ile-Glu-Gly-Arg-pNA as substrate preincubated for 3 mins prior to substrate addition by spectrophotometry


Bioorg Med Chem Lett 21: 7516-21 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.098
BindingDB Entry DOI: 10.7270/Q2MK6DBS
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50358869
PNG
(CHEMBL1923454)
Show SMILES Brc1ccc2cc(ccc2c1)S(=O)(=O)N[C@H]1CCCN(CC(=O)N2CCCC2)C1=O |r|
Show InChI InChI=1S/C21H24BrN3O4S/c22-17-7-5-16-13-18(8-6-15(16)12-17)30(28,29)23-19-4-3-11-25(21(19)27)14-20(26)24-9-1-2-10-24/h5-8,12-13,19,23H,1-4,9-11,14H2/t19-/m0/s1
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n/an/a 19n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Inhibition of human factor 10a using phenyl-Ile-Glu-Gly-Arg-pNA as substrate preincubated for 3 mins prior to substrate addition by spectrophotometry


Bioorg Med Chem Lett 21: 7516-21 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.098
BindingDB Entry DOI: 10.7270/Q2MK6DBS
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50358882
PNG
(CHEMBL1923467)
Show SMILES Clc1ccc2cc(ccc2c1)S(=O)(=O)N[C@H]1CCCN(CC(=O)N2CC3CNCC(C3)C2)C1=O |r|
Show InChI InChI=1S/C24H29ClN4O4S/c25-20-5-3-19-10-21(6-4-18(19)9-20)34(32,33)27-22-2-1-7-28(24(22)31)15-23(30)29-13-16-8-17(14-29)12-26-11-16/h3-6,9-10,16-17,22,26-27H,1-2,7-8,11-15H2/t16?,17?,22-/m0/s1
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n/an/a 22n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Inhibition of human factor 10a using phenyl-Ile-Glu-Gly-Arg-pNA as substrate preincubated for 3 mins prior to substrate addition by spectrophotometry


Bioorg Med Chem Lett 21: 7516-21 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.098
BindingDB Entry DOI: 10.7270/Q2MK6DBS
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM26351
PNG
(2-methylbenzofuran compound, 2 | 2-{[(2-methyl-1-b...)
Show SMILES Cc1cc2cc(ccc2o1)N=C(N[C@H]1CCCCN(CC(=O)N2CCCC2)C1=O)C(C#N)C#N |r,w:10.11|
Show InChI InChI=1S/C25H28N6O3/c1-17-12-18-13-20(7-8-22(18)34-17)28-24(19(14-26)15-27)29-21-6-2-3-11-31(25(21)33)16-23(32)30-9-4-5-10-30/h7-8,12-13,19,21H,2-6,9-11,16H2,1H3,(H,28,29)/t21-/m0/s1
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n/an/a 30n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Inhibition of human factor 10a using phenyl-Ile-Glu-Gly-Arg-pNA as substrate preincubated for 3 mins prior to substrate addition by spectrophotometry


Bioorg Med Chem Lett 21: 7516-21 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.098
BindingDB Entry DOI: 10.7270/Q2MK6DBS
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50358867
PNG
(CHEMBL1923453)
Show SMILES Clc1ccc2cc(ccc2c1)S(=O)(=O)N[C@H]1CCCN(CC(=O)N2CCCC2)C1=O |r|
Show InChI InChI=1S/C21H24ClN3O4S/c22-17-7-5-16-13-18(8-6-15(16)12-17)30(28,29)23-19-4-3-11-25(21(19)27)14-20(26)24-9-1-2-10-24/h5-8,12-13,19,23H,1-4,9-11,14H2/t19-/m0/s1
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n/an/a 32n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Inhibition of human factor 10a using phenyl-Ile-Glu-Gly-Arg-pNA as substrate preincubated for 3 mins prior to substrate addition by spectrophotometry


Bioorg Med Chem Lett 21: 7516-21 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.098
BindingDB Entry DOI: 10.7270/Q2MK6DBS
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50358886
PNG
(CHEMBL1923560)
Show SMILES NC(=O)C(=O)N1CC2CC(CN(C2)C(=O)CN2CCC[C@H](NS(=O)(=O)c3ccc4cc(Cl)ccc4c3)C2=O)C1 |r|
Show InChI InChI=1S/C26H30ClN5O6S/c27-20-5-3-19-10-21(6-4-18(19)9-20)39(37,38)29-22-2-1-7-30(25(22)35)15-23(33)31-11-16-8-17(12-31)14-32(13-16)26(36)24(28)34/h3-6,9-10,16-17,22,29H,1-2,7-8,11-15H2,(H2,28,34)/t16?,17?,22-/m0/s1
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n/an/a 32n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Inhibition of human factor 10a using phenyl-Ile-Glu-Gly-Arg-pNA as substrate preincubated for 3 mins prior to substrate addition by spectrophotometry


Bioorg Med Chem Lett 21: 7516-21 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.098
BindingDB Entry DOI: 10.7270/Q2MK6DBS
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50358870
PNG
(CHEMBL1923455)
Show SMILES Clc1ccc2nc([nH]c2c1)S(=O)(=O)N[C@H]1CCCN(CC(=O)N2CCCC2)C1=O |r|
Show InChI InChI=1S/C18H22ClN5O4S/c19-12-5-6-13-15(10-12)21-18(20-13)29(27,28)22-14-4-3-9-24(17(14)26)11-16(25)23-7-1-2-8-23/h5-6,10,14,22H,1-4,7-9,11H2,(H,20,21)/t14-/m0/s1
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n/an/a 32n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Inhibition of human factor 10a using phenyl-Ile-Glu-Gly-Arg-pNA as substrate preincubated for 3 mins prior to substrate addition by spectrophotometry


Bioorg Med Chem Lett 21: 7516-21 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.098
BindingDB Entry DOI: 10.7270/Q2MK6DBS
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50358872
PNG
(CHEMBL1923456)
Show SMILES Clc1ccc(s1)-c1ccc(s1)S(=O)(=O)N[C@H]1CCCN(CC(=O)N2CCCC2)C1=O |r|
Show InChI InChI=1S/C19H22ClN3O4S3/c20-16-7-5-14(28-16)15-6-8-18(29-15)30(26,27)21-13-4-3-11-23(19(13)25)12-17(24)22-9-1-2-10-22/h5-8,13,21H,1-4,9-12H2/t13-/m0/s1
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n/an/a 51n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Inhibition of human factor 10a using phenyl-Ile-Glu-Gly-Arg-pNA as substrate preincubated for 3 mins prior to substrate addition by spectrophotometry


Bioorg Med Chem Lett 21: 7516-21 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.098
BindingDB Entry DOI: 10.7270/Q2MK6DBS
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50358875
PNG
(CHEMBL1923461)
Show SMILES Clc1ccc2cc(ccc2c1)S(=O)(=O)N[C@H]1CCCN(CC(=O)N2CCSC2)C1=O |r|
Show InChI InChI=1S/C20H22ClN3O4S2/c21-16-5-3-15-11-17(6-4-14(15)10-16)30(27,28)22-18-2-1-7-23(20(18)26)12-19(25)24-8-9-29-13-24/h3-6,10-11,18,22H,1-2,7-9,12-13H2/t18-/m0/s1
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n/an/a 58n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Inhibition of human factor 10a using phenyl-Ile-Glu-Gly-Arg-pNA as substrate preincubated for 3 mins prior to substrate addition by spectrophotometry


Bioorg Med Chem Lett 21: 7516-21 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.098
BindingDB Entry DOI: 10.7270/Q2MK6DBS
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50358863
PNG
(CHEMBL1923448)
Show SMILES Clc1ccc2sc(cc2c1)S(=O)(=O)N[C@H]1CCCN(CC(=O)N2CCCC2)C1=O |r|
Show InChI InChI=1S/C19H22ClN3O4S2/c20-14-5-6-16-13(10-14)11-18(28-16)29(26,27)21-15-4-3-9-23(19(15)25)12-17(24)22-7-1-2-8-22/h5-6,10-11,15,21H,1-4,7-9,12H2/t15-/m0/s1
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n/an/a 60n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Inhibition of human factor 10a using phenyl-Ile-Glu-Gly-Arg-pNA as substrate preincubated for 3 mins prior to substrate addition by spectrophotometry


Bioorg Med Chem Lett 21: 7516-21 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.098
BindingDB Entry DOI: 10.7270/Q2MK6DBS
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50358859
PNG
(CHEMBL1923444)
Show SMILES Clc1ccc(\C=C\S(=O)(=O)N[C@H]2CCCN(CC(=O)N3CCCC3)C2=O)s1 |r|
Show InChI InChI=1S/C17H22ClN3O4S2/c18-15-6-5-13(26-15)7-11-27(24,25)19-14-4-3-10-21(17(14)23)12-16(22)20-8-1-2-9-20/h5-7,11,14,19H,1-4,8-10,12H2/b11-7+/t14-/m0/s1
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n/an/a 61n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Inhibition of human factor 10a using phenyl-Ile-Glu-Gly-Arg-pNA as substrate preincubated for 3 mins prior to substrate addition by spectrophotometry


Bioorg Med Chem Lett 21: 7516-21 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.098
BindingDB Entry DOI: 10.7270/Q2MK6DBS
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50358877
PNG
(CHEMBL1923462)
Show SMILES Clc1ccc2cc(ccc2c1)S(=O)(=O)N[C@H]1CCCN(CC(=O)N2CCCCC2)C1=O |r|
Show InChI InChI=1S/C22H26ClN3O4S/c23-18-8-6-17-14-19(9-7-16(17)13-18)31(29,30)24-20-5-4-12-26(22(20)28)15-21(27)25-10-2-1-3-11-25/h6-9,13-14,20,24H,1-5,10-12,15H2/t20-/m0/s1
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n/an/a 121n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Inhibition of human factor 10a using phenyl-Ile-Glu-Gly-Arg-pNA as substrate preincubated for 3 mins prior to substrate addition by spectrophotometry


Bioorg Med Chem Lett 21: 7516-21 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.098
BindingDB Entry DOI: 10.7270/Q2MK6DBS
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50358862
PNG
(CHEMBL1923447)
Show SMILES Clc1ccc2cc(sc2c1)S(=O)(=O)N[C@H]1CCCN(CC(=O)N2CCCC2)C1=O |r|
Show InChI InChI=1S/C19H22ClN3O4S2/c20-14-6-5-13-10-18(28-16(13)11-14)29(26,27)21-15-4-3-9-23(19(15)25)12-17(24)22-7-1-2-8-22/h5-6,10-11,15,21H,1-4,7-9,12H2/t15-/m0/s1
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n/an/a 122n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Inhibition of human factor 10a using phenyl-Ile-Glu-Gly-Arg-pNA as substrate preincubated for 3 mins prior to substrate addition by spectrophotometry


Bioorg Med Chem Lett 21: 7516-21 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.098
BindingDB Entry DOI: 10.7270/Q2MK6DBS
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50358874
PNG
(CHEMBL1923459)
Show SMILES Clc1ccc2cc(ccc2c1)S(=O)(=O)N[C@H]1CCCN(CC(=O)N2CCCC2c2cccnc2)C1=O |r|
Show InChI InChI=1S/C26H27ClN4O4S/c27-21-9-7-19-15-22(10-8-18(19)14-21)36(34,35)29-23-5-2-12-30(26(23)33)17-25(32)31-13-3-6-24(31)20-4-1-11-28-16-20/h1,4,7-11,14-16,23-24,29H,2-3,5-6,12-13,17H2/t23-,24?/m0/s1
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n/an/a 129n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Inhibition of human factor 10a using phenyl-Ile-Glu-Gly-Arg-pNA as substrate preincubated for 3 mins prior to substrate addition by spectrophotometry


Bioorg Med Chem Lett 21: 7516-21 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.098
BindingDB Entry DOI: 10.7270/Q2MK6DBS
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50358873
PNG
(CHEMBL1923458)
Show SMILES CC1CCCN1C(=O)CN1CCC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O |r|
Show InChI InChI=1S/C22H26ClN3O4S/c1-15-4-2-11-26(15)21(27)14-25-10-3-5-20(22(25)28)24-31(29,30)19-9-7-16-12-18(23)8-6-17(16)13-19/h6-9,12-13,15,20,24H,2-5,10-11,14H2,1H3/t15?,20-/m0/s1
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n/an/a 130n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Inhibition of human factor 10a using phenyl-Ile-Glu-Gly-Arg-pNA as substrate preincubated for 3 mins prior to substrate addition by spectrophotometry


Bioorg Med Chem Lett 21: 7516-21 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.098
BindingDB Entry DOI: 10.7270/Q2MK6DBS
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50358880
PNG
(CHEMBL1923465)
Show SMILES NCC1CCCN(C1)C(=O)CN1CCC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O |r|
Show InChI InChI=1S/C23H29ClN4O4S/c24-19-7-5-18-12-20(8-6-17(18)11-19)33(31,32)26-21-4-2-10-28(23(21)30)15-22(29)27-9-1-3-16(13-25)14-27/h5-8,11-12,16,21,26H,1-4,9-10,13-15,25H2/t16?,21-/m0/s1
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n/an/a 209n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Inhibition of human factor 10a using phenyl-Ile-Glu-Gly-Arg-pNA as substrate preincubated for 3 mins prior to substrate addition by spectrophotometry


Bioorg Med Chem Lett 21: 7516-21 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.098
BindingDB Entry DOI: 10.7270/Q2MK6DBS
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50358876
PNG
(CHEMBL1923460)
Show SMILES Clc1ccc2cc(ccc2c1)S(=O)(=O)N[C@H]1CCCN(CC(=O)N2CCC(C2)c2cccnc2)C1=O |r|
Show InChI InChI=1S/C26H27ClN4O4S/c27-22-7-5-19-14-23(8-6-18(19)13-22)36(34,35)29-24-4-2-11-31(26(24)33)17-25(32)30-12-9-21(16-30)20-3-1-10-28-15-20/h1,3,5-8,10,13-15,21,24,29H,2,4,9,11-12,16-17H2/t21?,24-/m0/s1
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n/an/a 337n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Inhibition of human factor 10a using phenyl-Ile-Glu-Gly-Arg-pNA as substrate preincubated for 3 mins prior to substrate addition by spectrophotometry


Bioorg Med Chem Lett 21: 7516-21 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.098
BindingDB Entry DOI: 10.7270/Q2MK6DBS
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50358878
PNG
(CHEMBL1923463)
Show SMILES Clc1ccc2cc(ccc2c1)S(=O)(=O)N[C@H]1CCCN(CC(=O)N2CCOCC2)C1=O |r|
Show InChI InChI=1S/C21H24ClN3O5S/c22-17-5-3-16-13-18(6-4-15(16)12-17)31(28,29)23-19-2-1-7-25(21(19)27)14-20(26)24-8-10-30-11-9-24/h3-6,12-13,19,23H,1-2,7-11,14H2/t19-/m0/s1
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n/an/a 674n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Inhibition of human factor 10a using phenyl-Ile-Glu-Gly-Arg-pNA as substrate preincubated for 3 mins prior to substrate addition by spectrophotometry


Bioorg Med Chem Lett 21: 7516-21 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.098
BindingDB Entry DOI: 10.7270/Q2MK6DBS
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50358868
PNG
(CHEMBL1923452)
Show SMILES Clc1ccc2ccc(cc2c1)S(=O)(=O)N[C@H]1CCCN(CC(=O)N2CCCC2)C1=O |r|
Show InChI InChI=1S/C21H24ClN3O4S/c22-17-7-5-15-6-8-18(13-16(15)12-17)30(28,29)23-19-4-3-11-25(21(19)27)14-20(26)24-9-1-2-10-24/h5-8,12-13,19,23H,1-4,9-11,14H2/t19-/m0/s1
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n/an/a 1.01E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Inhibition of human factor 10a using phenyl-Ile-Glu-Gly-Arg-pNA as substrate preincubated for 3 mins prior to substrate addition by spectrophotometry


Bioorg Med Chem Lett 21: 7516-21 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.098
BindingDB Entry DOI: 10.7270/Q2MK6DBS
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50358860
PNG
(CHEMBL1923445)
Show SMILES Cc1ccc(\C=C\S(=O)(=O)N[C@H]2CCCN(CC(=O)N3CCCC3)C2=O)s1 |r|
Show InChI InChI=1S/C18H25N3O4S2/c1-14-6-7-15(26-14)8-12-27(24,25)19-16-5-4-11-21(18(16)23)13-17(22)20-9-2-3-10-20/h6-8,12,16,19H,2-5,9-11,13H2,1H3/b12-8+/t16-/m0/s1
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n/an/a 1.02E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Inhibition of human factor 10a using phenyl-Ile-Glu-Gly-Arg-pNA as substrate preincubated for 3 mins prior to substrate addition by spectrophotometry


Bioorg Med Chem Lett 21: 7516-21 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.098
BindingDB Entry DOI: 10.7270/Q2MK6DBS
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50358856
PNG
(CHEMBL1923441)
Show SMILES Cc1cc2cc(ccc2o1)S(=O)(=O)N[C@H]1CCCN(CC(=O)N2CCCC2)C1=O |r|
Show InChI InChI=1S/C20H25N3O5S/c1-14-11-15-12-16(6-7-18(15)28-14)29(26,27)21-17-5-4-10-23(20(17)25)13-19(24)22-8-2-3-9-22/h6-7,11-12,17,21H,2-5,8-10,13H2,1H3/t17-/m0/s1
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n/an/a 1.11E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Inhibition of human factor 10a using phenyl-Ile-Glu-Gly-Arg-pNA as substrate preincubated for 3 mins prior to substrate addition by spectrophotometry


Bioorg Med Chem Lett 21: 7516-21 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.098
BindingDB Entry DOI: 10.7270/Q2MK6DBS
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50358881
PNG
(CHEMBL1923466)
Show SMILES NCC1CCN(CC1)C(=O)CN1CCC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O |r|
Show InChI InChI=1S/C23H29ClN4O4S/c24-19-5-3-18-13-20(6-4-17(18)12-19)33(31,32)26-21-2-1-9-28(23(21)30)15-22(29)27-10-7-16(14-25)8-11-27/h3-6,12-13,16,21,26H,1-2,7-11,14-15,25H2/t21-/m0/s1
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n/an/a 1.33E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Inhibition of human factor 10a using phenyl-Ile-Glu-Gly-Arg-pNA as substrate preincubated for 3 mins prior to substrate addition by spectrophotometry


Bioorg Med Chem Lett 21: 7516-21 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.098
BindingDB Entry DOI: 10.7270/Q2MK6DBS
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50358865
PNG
(CHEMBL1923450)
Show SMILES O=C(CN1CCC[C@H](NS(=O)(=O)c2ccc3ccccc3c2)C1=O)N1CCCC1 |r|
Show InChI InChI=1S/C21H25N3O4S/c25-20(23-11-3-4-12-23)15-24-13-5-8-19(21(24)26)22-29(27,28)18-10-9-16-6-1-2-7-17(16)14-18/h1-2,6-7,9-10,14,19,22H,3-5,8,11-13,15H2/t19-/m0/s1
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n/an/a 1.71E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Inhibition of human factor 10a using phenyl-Ile-Glu-Gly-Arg-pNA as substrate preincubated for 3 mins prior to substrate addition by spectrophotometry


Bioorg Med Chem Lett 21: 7516-21 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.098
BindingDB Entry DOI: 10.7270/Q2MK6DBS
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50358864
PNG
(CHEMBL1923449)
Show SMILES Cc1ccc2sc(cc2c1)S(=O)(=O)N[C@H]1CCCN(CC(=O)N2CCCC2)C1=O |r|
Show InChI InChI=1S/C20H25N3O4S2/c1-14-6-7-17-15(11-14)12-19(28-17)29(26,27)21-16-5-4-10-23(20(16)25)13-18(24)22-8-2-3-9-22/h6-7,11-12,16,21H,2-5,8-10,13H2,1H3/t16-/m0/s1
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n/an/a 1.95E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Inhibition of human factor 10a using phenyl-Ile-Glu-Gly-Arg-pNA as substrate preincubated for 3 mins prior to substrate addition by spectrophotometry


Bioorg Med Chem Lett 21: 7516-21 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.098
BindingDB Entry DOI: 10.7270/Q2MK6DBS
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50358879
PNG
(CHEMBL1923464)
Show SMILES CN1CCN(CC1)C(=O)CN1CCC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O |r|
Show InChI InChI=1S/C22H27ClN4O4S/c1-25-9-11-26(12-10-25)21(28)15-27-8-2-3-20(22(27)29)24-32(30,31)19-7-5-16-13-18(23)6-4-17(16)14-19/h4-7,13-14,20,24H,2-3,8-12,15H2,1H3/t20-/m0/s1
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n/an/a 1.96E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Inhibition of human factor 10a using phenyl-Ile-Glu-Gly-Arg-pNA as substrate preincubated for 3 mins prior to substrate addition by spectrophotometry


Bioorg Med Chem Lett 21: 7516-21 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.098
BindingDB Entry DOI: 10.7270/Q2MK6DBS
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50358866
PNG
(CHEMBL1923451)
Show SMILES Clc1cccc2cc(ccc12)S(=O)(=O)N[C@H]1CCCN(CC(=O)N2CCCC2)C1=O |r|
Show InChI InChI=1S/C21H24ClN3O4S/c22-18-6-3-5-15-13-16(8-9-17(15)18)30(28,29)23-19-7-4-12-25(21(19)27)14-20(26)24-10-1-2-11-24/h3,5-6,8-9,13,19,23H,1-2,4,7,10-12,14H2/t19-/m0/s1
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n/an/a 2.22E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Inhibition of human factor 10a using phenyl-Ile-Glu-Gly-Arg-pNA as substrate preincubated for 3 mins prior to substrate addition by spectrophotometry


Bioorg Med Chem Lett 21: 7516-21 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.098
BindingDB Entry DOI: 10.7270/Q2MK6DBS
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50358861
PNG
(CHEMBL1923446)
Show SMILES O=C(CN1CCC[C@H](NS(=O)(=O)c2cc3ccccc3s2)C1=O)N1CCCC1 |r|
Show InChI InChI=1S/C19H23N3O4S2/c23-17(21-9-3-4-10-21)13-22-11-5-7-15(19(22)24)20-28(25,26)18-12-14-6-1-2-8-16(14)27-18/h1-2,6,8,12,15,20H,3-5,7,9-11,13H2/t15-/m0/s1
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n/an/a 2.79E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Inhibition of human factor 10a using phenyl-Ile-Glu-Gly-Arg-pNA as substrate preincubated for 3 mins prior to substrate addition by spectrophotometry


Bioorg Med Chem Lett 21: 7516-21 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.098
BindingDB Entry DOI: 10.7270/Q2MK6DBS
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50358857
PNG
(CHEMBL1923442)
Show SMILES Brc1ccc(cc1)S(=O)(=O)N[C@H]1CCCN(CC(=O)N2CCCC2)C1=O |r|
Show InChI InChI=1S/C17H22BrN3O4S/c18-13-5-7-14(8-6-13)26(24,25)19-15-4-3-11-21(17(15)23)12-16(22)20-9-1-2-10-20/h5-8,15,19H,1-4,9-12H2/t15-/m0/s1
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n/an/a 9.75E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Inhibition of human factor 10a using phenyl-Ile-Glu-Gly-Arg-pNA as substrate preincubated for 3 mins prior to substrate addition by spectrophotometry


Bioorg Med Chem Lett 21: 7516-21 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.098
BindingDB Entry DOI: 10.7270/Q2MK6DBS
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50358858
PNG
(CHEMBL1923443)
Show SMILES Clc1ccc(s1)S(=O)(=O)N[C@H]1CCCN(CC(=O)N2CCCC2)C1=O |r|
Show InChI InChI=1S/C15H20ClN3O4S2/c16-12-5-6-14(24-12)25(22,23)17-11-4-3-9-19(15(11)21)10-13(20)18-7-1-2-8-18/h5-6,11,17H,1-4,7-10H2/t11-/m0/s1
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n/an/a 1.18E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Inhibition of human factor 10a using phenyl-Ile-Glu-Gly-Arg-pNA as substrate preincubated for 3 mins prior to substrate addition by spectrophotometry


Bioorg Med Chem Lett 21: 7516-21 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.098
BindingDB Entry DOI: 10.7270/Q2MK6DBS
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%