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PubMed code 22078216

Compile data set for download or QSAR
Found 146 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein kinase C eta type


(Homo sapiens (Human))
BDBM50391897
PNG
(CHEMBL2147537)
Show SMILES C[C@H](N)CNc1nc(cc2cnccc12)-c1ccncc1 |r|
Show InChI InChI=1S/C16H17N5/c1-11(17)9-20-16-14-4-7-19-10-13(14)8-15(21-16)12-2-5-18-6-3-12/h2-8,10-11H,9,17H2,1H3,(H,20,21)/t11-/m0/s1
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n/an/a 2n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCeta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity ass...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C eta type


(Homo sapiens (Human))
BDBM50391902
PNG
(CHEMBL2147542)
Show SMILES C1CNCCN(C1)c1nc(cc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C18H19N5/c1-5-19-9-11-23(10-1)18-16-4-8-21-13-15(16)12-17(22-18)14-2-6-20-7-3-14/h2-4,6-8,12-13,19H,1,5,9-11H2
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n/an/a 4n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCeta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity ass...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C epsilon type


(Homo sapiens (Human))
BDBM50391897
PNG
(CHEMBL2147537)
Show SMILES C[C@H](N)CNc1nc(cc2cnccc12)-c1ccncc1 |r|
Show InChI InChI=1S/C16H17N5/c1-11(17)9-20-16-14-4-7-19-10-13(14)8-15(21-16)12-2-5-18-6-3-12/h2-8,10-11H,9,17H2,1H3,(H,20,21)/t11-/m0/s1
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n/an/a 5n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCepsilon assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C eta type


(Homo sapiens (Human))
BDBM50324316
PNG
(CHEMBL1214929 | N*1*-(3-Pyridin-4-yl[2,6]naphthyri...)
Show SMILES NCCNc1nc(cc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C15H15N5/c16-4-8-19-15-13-3-7-18-10-12(13)9-14(20-15)11-1-5-17-6-2-11/h1-3,5-7,9-10H,4,8,16H2,(H,19,20)
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n/an/a 5n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCeta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity ass...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C epsilon type


(Homo sapiens (Human))
BDBM50324316
PNG
(CHEMBL1214929 | N*1*-(3-Pyridin-4-yl[2,6]naphthyri...)
Show SMILES NCCNc1nc(cc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C15H15N5/c16-4-8-19-15-13-3-7-18-10-12(13)9-14(20-15)11-1-5-17-6-2-11/h1-3,5-7,9-10H,4,8,16H2,(H,19,20)
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n/an/a 5n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCepsilon assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C eta type


(Homo sapiens (Human))
BDBM50324319
PNG
(1-Piperazin-1-yl-3-pyridin-4-yl[2,6]naphthyridine ...)
Show SMILES C1CN(CCN1)c1nc(cc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C17H17N5/c1-4-18-5-2-13(1)16-11-14-12-20-6-3-15(14)17(21-16)22-9-7-19-8-10-22/h1-6,11-12,19H,7-10H2
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n/an/a 6n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCeta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity ass...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C epsilon type


(Homo sapiens (Human))
BDBM50391902
PNG
(CHEMBL2147542)
Show SMILES C1CNCCN(C1)c1nc(cc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C18H19N5/c1-5-19-9-11-23(10-1)18-16-4-8-21-13-15(16)12-17(22-18)14-2-6-20-7-3-14/h2-4,6-8,12-13,19H,1,5,9-11H2
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n/an/a 7n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCepsilon assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C epsilon type


(Homo sapiens (Human))
BDBM50324319
PNG
(1-Piperazin-1-yl-3-pyridin-4-yl[2,6]naphthyridine ...)
Show SMILES C1CN(CCN1)c1nc(cc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C17H17N5/c1-4-18-5-2-13(1)16-11-14-12-20-6-3-15(14)17(21-16)22-9-7-19-8-10-22/h1-6,11-12,19H,7-10H2
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n/an/a 8n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCepsilon assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C epsilon type


(Homo sapiens (Human))
BDBM50391903
PNG
(CHEMBL2147543)
Show SMILES NC1CCCN(C1)c1nc(cc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C18H19N5/c19-15-2-1-9-23(12-15)18-16-5-8-21-11-14(16)10-17(22-18)13-3-6-20-7-4-13/h3-8,10-11,15H,1-2,9,12,19H2
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n/an/a 8n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCepsilon assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM50391897
PNG
(CHEMBL2147537)
Show SMILES C[C@H](N)CNc1nc(cc2cnccc12)-c1ccncc1 |r|
Show InChI InChI=1S/C16H17N5/c1-11(17)9-20-16-14-4-7-19-10-13(14)8-15(21-16)12-2-5-18-6-3-12/h2-8,10-11H,9,17H2,1H3,(H,20,21)/t11-/m0/s1
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n/an/a 8n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCdelta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C eta type


(Homo sapiens (Human))
BDBM50391898
PNG
(CHEMBL2147538)
Show SMILES CC(C)(N)CNc1nc(cc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C17H19N5/c1-17(2,18)11-21-16-14-5-8-20-10-13(14)9-15(22-16)12-3-6-19-7-4-12/h3-10H,11,18H2,1-2H3,(H,21,22)
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n/an/a 9n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCeta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity ass...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Protein kinase C eta type


(Homo sapiens (Human))
BDBM50391904
PNG
(CHEMBL2147544)
Show SMILES NCCCNc1nc(cc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C16H17N5/c17-5-1-6-20-16-14-4-9-19-11-13(14)10-15(21-16)12-2-7-18-8-3-12/h2-4,7-11H,1,5-6,17H2,(H,20,21)
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n/an/a 10n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCeta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity ass...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C eta type


(Homo sapiens (Human))
BDBM50391903
PNG
(CHEMBL2147543)
Show SMILES NC1CCCN(C1)c1nc(cc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C18H19N5/c19-15-2-1-9-23(12-15)18-16-5-8-21-11-14(16)10-17(22-18)13-3-6-20-7-4-13/h3-8,10-11,15H,1-2,9,12,19H2
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n/an/a 13n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCeta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity ass...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C epsilon type


(Homo sapiens (Human))
BDBM50391904
PNG
(CHEMBL2147544)
Show SMILES NCCCNc1nc(cc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C16H17N5/c17-5-1-6-20-16-14-4-9-19-11-13(14)10-15(21-16)12-2-7-18-8-3-12/h2-4,7-11H,1,5-6,17H2,(H,20,21)
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n/an/a 13n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCepsilon assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C eta type


(Homo sapiens (Human))
BDBM50391911
PNG
(CHEMBL2147551)
Show SMILES CC(C)(N)CNc1nc(cc2cnccc12)-c1ccncc1Cl
Show InChI InChI=1S/C17H18ClN5/c1-17(2,19)10-22-16-12-3-5-20-8-11(12)7-15(23-16)13-4-6-21-9-14(13)18/h3-9H,10,19H2,1-2H3,(H,22,23)
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n/an/a 15n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCeta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity ass...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C epsilon type


(Homo sapiens (Human))
BDBM50391898
PNG
(CHEMBL2147538)
Show SMILES CC(C)(N)CNc1nc(cc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C17H19N5/c1-17(2,18)11-21-16-14-5-8-20-10-13(14)9-15(22-16)12-3-6-19-7-4-12/h3-10H,11,18H2,1-2H3,(H,21,22)
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n/an/a 18n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCepsilon assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C eta type


(Homo sapiens (Human))
BDBM50391910
PNG
(CHEMBL2147550)
Show SMILES CC(C)(N)CNc1nc(cc2cnccc12)-c1ccncc1F
Show InChI InChI=1S/C17H18FN5/c1-17(2,19)10-22-16-12-3-5-20-8-11(12)7-15(23-16)13-4-6-21-9-14(13)18/h3-9H,10,19H2,1-2H3,(H,22,23)
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n/an/a 18n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCeta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity ass...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM50324316
PNG
(CHEMBL1214929 | N*1*-(3-Pyridin-4-yl[2,6]naphthyri...)
Show SMILES NCCNc1nc(cc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C15H15N5/c16-4-8-19-15-13-3-7-18-10-12(13)9-14(20-15)11-1-5-17-6-2-11/h1-3,5-7,9-10H,4,8,16H2,(H,19,20)
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n/an/a 20n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCdelta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C epsilon type


(Homo sapiens (Human))
BDBM50391900
PNG
(CHEMBL2147540)
Show SMILES CN(CCN)c1nc(cc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C16H17N5/c1-21(9-5-17)16-14-4-8-19-11-13(14)10-15(20-16)12-2-6-18-7-3-12/h2-4,6-8,10-11H,5,9,17H2,1H3
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n/an/a 24n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCepsilon assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C eta type


(Homo sapiens (Human))
BDBM50391895
PNG
(CHEMBL2147535 | US11458138, Example 313)
Show SMILES NCCNc1nc(nc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C14H14N6/c15-4-8-18-14-11-3-7-17-9-12(11)19-13(20-14)10-1-5-16-6-2-10/h1-3,5-7,9H,4,8,15H2,(H,18,19,20)
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n/an/a 27n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCeta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity ass...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM50324319
PNG
(1-Piperazin-1-yl-3-pyridin-4-yl[2,6]naphthyridine ...)
Show SMILES C1CN(CCN1)c1nc(cc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C17H17N5/c1-4-18-5-2-13(1)16-11-14-12-20-6-3-15(14)17(21-16)22-9-7-19-8-10-22/h1-6,11-12,19H,7-10H2
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n/an/a 31n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCdelta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C eta type


(Homo sapiens (Human))
BDBM50391900
PNG
(CHEMBL2147540)
Show SMILES CN(CCN)c1nc(cc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C16H17N5/c1-21(9-5-17)16-14-4-8-19-11-13(14)10-15(20-16)12-2-6-18-7-3-12/h2-4,6-8,10-11H,5,9,17H2,1H3
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n/an/a 34n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCeta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity ass...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C epsilon type


(Homo sapiens (Human))
BDBM50391895
PNG
(CHEMBL2147535 | US11458138, Example 313)
Show SMILES NCCNc1nc(nc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C14H14N6/c15-4-8-18-14-11-3-7-17-9-12(11)19-13(20-14)10-1-5-16-6-2-10/h1-3,5-7,9H,4,8,15H2,(H,18,19,20)
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n/an/a 38n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCepsilon assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM50391898
PNG
(CHEMBL2147538)
Show SMILES CC(C)(N)CNc1nc(cc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C17H19N5/c1-17(2,18)11-21-16-14-5-8-20-10-13(14)9-15(22-16)12-3-6-19-7-4-12/h3-10H,11,18H2,1-2H3,(H,21,22)
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n/an/a 44n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCdelta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C epsilon type


(Homo sapiens (Human))
BDBM50391894
PNG
(CHEMBL2147534)
Show SMILES NCCNc1cc(cc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C16H16N4/c17-4-8-20-16-10-13(12-1-5-18-6-2-12)9-14-11-19-7-3-15(14)16/h1-3,5-7,9-11,20H,4,8,17H2
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n/an/a 44n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCepsilon assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C epsilon type


(Homo sapiens (Human))
BDBM50391911
PNG
(CHEMBL2147551)
Show SMILES CC(C)(N)CNc1nc(cc2cnccc12)-c1ccncc1Cl
Show InChI InChI=1S/C17H18ClN5/c1-17(2,19)10-22-16-12-3-5-20-8-11(12)7-15(23-16)13-4-6-21-9-14(13)18/h3-9H,10,19H2,1-2H3,(H,22,23)
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n/an/a 47n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCepsilon assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C eta type


(Homo sapiens (Human))
BDBM50391912
PNG
(CHEMBL2147552)
Show SMILES Cc1cnccc1-c1cc2cnccc2c(NCC(C)(C)N)n1
Show InChI InChI=1S/C18H21N5/c1-12-9-20-6-4-14(12)16-8-13-10-21-7-5-15(13)17(23-16)22-11-18(2,3)19/h4-10H,11,19H2,1-3H3,(H,22,23)
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n/an/a 52n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCeta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity ass...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM50391904
PNG
(CHEMBL2147544)
Show SMILES NCCCNc1nc(cc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C16H17N5/c17-5-1-6-20-16-14-4-9-19-11-13(14)10-15(21-16)12-2-7-18-8-3-12/h2-4,7-11H,1,5-6,17H2,(H,20,21)
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n/an/a 53n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCdelta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C eta type


(Homo sapiens (Human))
BDBM50391894
PNG
(CHEMBL2147534)
Show SMILES NCCNc1cc(cc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C16H16N4/c17-4-8-20-16-10-13(12-1-5-18-6-2-12)9-14-11-19-7-3-15(14)16/h1-3,5-7,9-11,20H,4,8,17H2
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n/an/a 54n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCeta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity ass...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50391897
PNG
(CHEMBL2147537)
Show SMILES C[C@H](N)CNc1nc(cc2cnccc12)-c1ccncc1 |r|
Show InChI InChI=1S/C16H17N5/c1-11(17)9-20-16-14-4-7-19-10-13(14)8-15(21-16)12-2-5-18-6-3-12/h2-8,10-11H,9,17H2,1H3,(H,20,21)/t11-/m0/s1
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n/an/a 55n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCtheta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C eta type


(Homo sapiens (Human))
BDBM50391908
PNG
(CHEMBL2147548)
Show SMILES CC(C)(N)CNc1nc(cc2cnccc12)-c1ccnc(N)c1
Show InChI InChI=1S/C17H20N6/c1-17(2,19)10-22-16-13-4-5-20-9-12(13)7-14(23-16)11-3-6-21-15(18)8-11/h3-9H,10,19H2,1-2H3,(H2,18,21)(H,22,23)
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n/an/a 60n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCeta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity ass...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C epsilon type


(Homo sapiens (Human))
BDBM50391910
PNG
(CHEMBL2147550)
Show SMILES CC(C)(N)CNc1nc(cc2cnccc12)-c1ccncc1F
Show InChI InChI=1S/C17H18FN5/c1-17(2,19)10-22-16-12-3-5-20-8-11(12)7-15(23-16)13-4-6-21-9-14(13)18/h3-9H,10,19H2,1-2H3,(H,22,23)
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n/an/a 62n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCepsilon assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM50391902
PNG
(CHEMBL2147542)
Show SMILES C1CNCCN(C1)c1nc(cc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C18H19N5/c1-5-19-9-11-23(10-1)18-16-4-8-21-13-15(16)12-17(22-18)14-2-6-20-7-3-14/h2-4,6-8,12-13,19H,1,5,9-11H2
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n/an/a 63n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCdelta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50324316
PNG
(CHEMBL1214929 | N*1*-(3-Pyridin-4-yl[2,6]naphthyri...)
Show SMILES NCCNc1nc(cc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C15H15N5/c16-4-8-19-15-13-3-7-18-10-12(13)9-14(20-15)11-1-5-17-6-2-11/h1-3,5-7,9-10H,4,8,16H2,(H,19,20)
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n/an/a 77n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCtheta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50391902
PNG
(CHEMBL2147542)
Show SMILES C1CNCCN(C1)c1nc(cc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C18H19N5/c1-5-19-9-11-23(10-1)18-16-4-8-21-13-15(16)12-17(22-18)14-2-6-20-7-3-14/h2-4,6-8,12-13,19H,1,5,9-11H2
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n/an/a 77n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCtheta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C epsilon type


(Homo sapiens (Human))
BDBM50391901
PNG
(CHEMBL2147541)
Show SMILES CNCCNc1nc(cc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C16H17N5/c1-17-8-9-20-16-14-4-7-19-11-13(14)10-15(21-16)12-2-5-18-6-3-12/h2-7,10-11,17H,8-9H2,1H3,(H,20,21)
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n/an/a 79n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCepsilon assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C epsilon type


(Homo sapiens (Human))
BDBM50391905
PNG
(CHEMBL2147545)
Show SMILES OCCNc1nc(cc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C15H14N4O/c20-8-7-18-15-13-3-6-17-10-12(13)9-14(19-15)11-1-4-16-5-2-11/h1-6,9-10,20H,7-8H2,(H,18,19)
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n/an/a 81n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCepsilon assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C eta type


(Homo sapiens (Human))
BDBM50391896
PNG
(CHEMBL2147536)
Show SMILES NCCOc1nc(cc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C15H14N4O/c16-4-8-20-15-13-3-7-18-10-12(13)9-14(19-15)11-1-5-17-6-2-11/h1-3,5-7,9-10H,4,8,16H2
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n/an/a 82n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCeta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity ass...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C eta type


(Homo sapiens (Human))
BDBM50391901
PNG
(CHEMBL2147541)
Show SMILES CNCCNc1nc(cc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C16H17N5/c1-17-8-9-20-16-14-4-7-19-11-13(14)10-15(21-16)12-2-5-18-6-3-12/h2-7,10-11,17H,8-9H2,1H3,(H,20,21)
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n/an/a 93n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCeta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity ass...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50391911
PNG
(CHEMBL2147551)
Show SMILES CC(C)(N)CNc1nc(cc2cnccc12)-c1ccncc1Cl
Show InChI InChI=1S/C17H18ClN5/c1-17(2,19)10-22-16-12-3-5-20-8-11(12)7-15(23-16)13-4-6-21-9-14(13)18/h3-9H,10,19H2,1-2H3,(H,22,23)
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n/an/a 93n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCtheta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50391904
PNG
(CHEMBL2147544)
Show SMILES NCCCNc1nc(cc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C16H17N5/c17-5-1-6-20-16-14-4-9-19-11-13(14)10-15(21-16)12-2-7-18-8-3-12/h2-4,7-11H,1,5-6,17H2,(H,20,21)
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n/an/a 97n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCtheta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM50391895
PNG
(CHEMBL2147535 | US11458138, Example 313)
Show SMILES NCCNc1nc(nc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C14H14N6/c15-4-8-18-14-11-3-7-17-9-12(11)19-13(20-14)10-1-5-16-6-2-10/h1-3,5-7,9H,4,8,15H2,(H,18,19,20)
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n/an/a 102n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCdelta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50324319
PNG
(1-Piperazin-1-yl-3-pyridin-4-yl[2,6]naphthyridine ...)
Show SMILES C1CN(CCN1)c1nc(cc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C17H17N5/c1-4-18-5-2-13(1)16-11-14-12-20-6-3-15(14)17(21-16)22-9-7-19-8-10-22/h1-6,11-12,19H,7-10H2
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n/an/a 109n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCtheta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C epsilon type


(Homo sapiens (Human))
BDBM50391896
PNG
(CHEMBL2147536)
Show SMILES NCCOc1nc(cc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C15H14N4O/c16-4-8-20-15-13-3-7-18-10-12(13)9-14(19-15)11-1-5-17-6-2-11/h1-3,5-7,9-10H,4,8,16H2
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n/an/a 120n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCepsilon assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM50391910
PNG
(CHEMBL2147550)
Show SMILES CC(C)(N)CNc1nc(cc2cnccc12)-c1ccncc1F
Show InChI InChI=1S/C17H18FN5/c1-17(2,19)10-22-16-12-3-5-20-8-11(12)7-15(23-16)13-4-6-21-9-14(13)18/h3-9H,10,19H2,1-2H3,(H,22,23)
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n/an/a 124n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCdelta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50391903
PNG
(CHEMBL2147543)
Show SMILES NC1CCCN(C1)c1nc(cc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C18H19N5/c19-15-2-1-9-23(12-15)18-16-5-8-21-11-14(16)10-17(22-18)13-3-6-20-7-4-13/h3-8,10-11,15H,1-2,9,12,19H2
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n/an/a 132n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCtheta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C epsilon type


(Homo sapiens (Human))
BDBM50391912
PNG
(CHEMBL2147552)
Show SMILES Cc1cnccc1-c1cc2cnccc2c(NCC(C)(C)N)n1
Show InChI InChI=1S/C18H21N5/c1-12-9-20-6-4-14(12)16-8-13-10-21-7-5-15(13)17(23-16)22-11-18(2,3)19/h4-10H,11,19H2,1-3H3,(H,22,23)
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n/an/a 133n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCepsilon assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50391910
PNG
(CHEMBL2147550)
Show SMILES CC(C)(N)CNc1nc(cc2cnccc12)-c1ccncc1F
Show InChI InChI=1S/C17H18FN5/c1-17(2,19)10-22-16-12-3-5-20-8-11(12)7-15(23-16)13-4-6-21-9-14(13)18/h3-9H,10,19H2,1-2H3,(H,22,23)
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n/an/a 140n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCtheta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50391898
PNG
(CHEMBL2147538)
Show SMILES CC(C)(N)CNc1nc(cc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C17H19N5/c1-17(2,18)11-21-16-14-5-8-20-10-13(14)9-15(22-16)12-3-6-19-7-4-12/h3-10H,11,18H2,1-2H3,(H,21,22)
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n/an/a 141n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCtheta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C epsilon type


(Homo sapiens (Human))
BDBM50391908
PNG
(CHEMBL2147548)
Show SMILES CC(C)(N)CNc1nc(cc2cnccc12)-c1ccnc(N)c1
Show InChI InChI=1S/C17H20N6/c1-17(2,19)10-22-16-13-4-5-20-9-12(13)7-14(23-16)11-3-6-21-15(18)8-11/h3-9H,10,19H2,1-2H3,(H2,18,21)(H,22,23)
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n/an/a 147n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCepsilon assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM50391894
PNG
(CHEMBL2147534)
Show SMILES NCCNc1cc(cc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C16H16N4/c17-4-8-20-16-10-13(12-1-5-18-6-2-12)9-14-11-19-7-3-15(14)16/h1-3,5-7,9-11,20H,4,8,17H2
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n/an/a 157n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCdelta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C eta type


(Homo sapiens (Human))
BDBM50391905
PNG
(CHEMBL2147545)
Show SMILES OCCNc1nc(cc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C15H14N4O/c20-8-7-18-15-13-3-6-17-10-12(13)9-14(19-15)11-1-4-16-5-2-11/h1-6,9-10,20H,7-8H2,(H,18,19)
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n/an/a 188n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCeta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity ass...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM50391903
PNG
(CHEMBL2147543)
Show SMILES NC1CCCN(C1)c1nc(cc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C18H19N5/c19-15-2-1-9-23(12-15)18-16-5-8-21-11-14(16)10-17(22-18)13-3-6-20-7-4-13/h3-8,10-11,15H,1-2,9,12,19H2
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n/an/a 214n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCdelta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM50391911
PNG
(CHEMBL2147551)
Show SMILES CC(C)(N)CNc1nc(cc2cnccc12)-c1ccncc1Cl
Show InChI InChI=1S/C17H18ClN5/c1-17(2,19)10-22-16-12-3-5-20-8-11(12)7-15(23-16)13-4-6-21-9-14(13)18/h3-9H,10,19H2,1-2H3,(H,22,23)
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n/an/a 221n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCdelta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM50391901
PNG
(CHEMBL2147541)
Show SMILES CNCCNc1nc(cc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C16H17N5/c1-17-8-9-20-16-14-4-7-19-11-13(14)10-15(21-16)12-2-5-18-6-3-12/h2-7,10-11,17H,8-9H2,1H3,(H,20,21)
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n/an/a 254n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCdelta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM50391908
PNG
(CHEMBL2147548)
Show SMILES CC(C)(N)CNc1nc(cc2cnccc12)-c1ccnc(N)c1
Show InChI InChI=1S/C17H20N6/c1-17(2,19)10-22-16-13-4-5-20-9-12(13)7-14(23-16)11-3-6-21-15(18)8-11/h3-9H,10,19H2,1-2H3,(H2,18,21)(H,22,23)
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n/an/a 294n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCdelta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50391900
PNG
(CHEMBL2147540)
Show SMILES CN(CCN)c1nc(cc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C16H17N5/c1-21(9-5-17)16-14-4-8-19-11-13(14)10-15(20-16)12-2-6-18-7-3-12/h2-4,6-8,10-11H,5,9,17H2,1H3
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n/an/a 350n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCtheta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50391894
PNG
(CHEMBL2147534)
Show SMILES NCCNc1cc(cc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C16H16N4/c17-4-8-20-16-10-13(12-1-5-18-6-2-12)9-14-11-19-7-3-15(14)16/h1-3,5-7,9-11,20H,4,8,17H2
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n/an/a 355n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCtheta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM50391900
PNG
(CHEMBL2147540)
Show SMILES CN(CCN)c1nc(cc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C16H17N5/c1-21(9-5-17)16-14-4-8-19-11-13(14)10-15(20-16)12-2-6-18-7-3-12/h2-4,6-8,10-11H,5,9,17H2,1H3
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n/an/a 371n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCdelta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM50391908
PNG
(CHEMBL2147548)
Show SMILES CC(C)(N)CNc1nc(cc2cnccc12)-c1ccnc(N)c1
Show InChI InChI=1S/C17H20N6/c1-17(2,19)10-22-16-13-4-5-20-9-12(13)7-14(23-16)11-3-6-21-15(18)8-11/h3-9H,10,19H2,1-2H3,(H2,18,21)(H,22,23)
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n/an/a 378n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCalpha assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM50391897
PNG
(CHEMBL2147537)
Show SMILES C[C@H](N)CNc1nc(cc2cnccc12)-c1ccncc1 |r|
Show InChI InChI=1S/C16H17N5/c1-11(17)9-20-16-14-4-7-19-10-13(14)8-15(21-16)12-2-5-18-6-3-12/h2-8,10-11H,9,17H2,1H3,(H,20,21)/t11-/m0/s1
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n/an/a 378n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCbeta1 assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM50391912
PNG
(CHEMBL2147552)
Show SMILES Cc1cnccc1-c1cc2cnccc2c(NCC(C)(C)N)n1
Show InChI InChI=1S/C18H21N5/c1-12-9-20-6-4-14(12)16-8-13-10-21-7-5-15(13)17(23-16)22-11-18(2,3)19/h4-10H,11,19H2,1-3H3,(H,22,23)
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n/an/a 386n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCdelta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C eta type


(Homo sapiens (Human))
BDBM50391893
PNG
(CHEMBL2147532)
Show SMILES NCCNc1nc(cc2ncccc12)-c1ccncc1
Show InChI InChI=1S/C15H15N5/c16-5-9-19-15-12-2-1-6-18-14(12)10-13(20-15)11-3-7-17-8-4-11/h1-4,6-8,10H,5,9,16H2,(H,19,20)
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n/an/a 401n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCeta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity ass...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C epsilon type


(Homo sapiens (Human))
BDBM50391899
PNG
(CHEMBL2147539)
Show SMILES NC(CNc1nc(cc2cnccc12)-c1ccncc1)Cc1ccccc1
Show InChI InChI=1S/C22H21N5/c23-19(12-16-4-2-1-3-5-16)15-26-22-20-8-11-25-14-18(20)13-21(27-22)17-6-9-24-10-7-17/h1-11,13-14,19H,12,15,23H2,(H,26,27)
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n/an/a 403n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCepsilon assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM50391902
PNG
(CHEMBL2147542)
Show SMILES C1CNCCN(C1)c1nc(cc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C18H19N5/c1-5-19-9-11-23(10-1)18-16-4-8-21-13-15(16)12-17(22-18)14-2-6-20-7-3-14/h2-4,6-8,12-13,19H,1,5,9-11H2
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n/an/a 433n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCalpha assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C eta type


(Homo sapiens (Human))
BDBM50391899
PNG
(CHEMBL2147539)
Show SMILES NC(CNc1nc(cc2cnccc12)-c1ccncc1)Cc1ccccc1
Show InChI InChI=1S/C22H21N5/c23-19(12-16-4-2-1-3-5-16)15-26-22-20-8-11-25-14-18(20)13-21(27-22)17-6-9-24-10-7-17/h1-11,13-14,19H,12,15,23H2,(H,26,27)
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n/an/a 452n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCeta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity ass...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50391908
PNG
(CHEMBL2147548)
Show SMILES CC(C)(N)CNc1nc(cc2cnccc12)-c1ccnc(N)c1
Show InChI InChI=1S/C17H20N6/c1-17(2,19)10-22-16-13-4-5-20-9-12(13)7-14(23-16)11-3-6-21-15(18)8-11/h3-9H,10,19H2,1-2H3,(H2,18,21)(H,22,23)
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n/an/a 496n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCtheta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM50391905
PNG
(CHEMBL2147545)
Show SMILES OCCNc1nc(cc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C15H14N4O/c20-8-7-18-15-13-3-6-17-10-12(13)9-14(19-15)11-1-4-16-5-2-11/h1-6,9-10,20H,7-8H2,(H,18,19)
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n/an/a 635n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCdelta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM50391902
PNG
(CHEMBL2147542)
Show SMILES C1CNCCN(C1)c1nc(cc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C18H19N5/c1-5-19-9-11-23(10-1)18-16-4-8-21-13-15(16)12-17(22-18)14-2-6-20-7-3-14/h2-4,6-8,12-13,19H,1,5,9-11H2
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n/an/a 661n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCbeta1 assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM50391904
PNG
(CHEMBL2147544)
Show SMILES NCCCNc1nc(cc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C16H17N5/c17-5-1-6-20-16-14-4-9-19-11-13(14)10-15(21-16)12-2-7-18-8-3-12/h2-4,7-11H,1,5-6,17H2,(H,20,21)
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n/an/a 676n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCalpha assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM50391896
PNG
(CHEMBL2147536)
Show SMILES NCCOc1nc(cc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C15H14N4O/c16-4-8-20-15-13-3-7-18-10-12(13)9-14(19-15)11-1-5-17-6-2-11/h1-3,5-7,9-10H,4,8,16H2
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n/an/a 703n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCdelta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C eta type


(Homo sapiens (Human))
BDBM50391906
PNG
(CHEMBL2147546)
Show SMILES O=C1CN(CCN1)c1nc(cc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C17H15N5O/c23-16-11-22(8-7-20-16)17-14-3-6-19-10-13(14)9-15(21-17)12-1-4-18-5-2-12/h1-6,9-10H,7-8,11H2,(H,20,23)
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n/an/a 735n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCeta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity ass...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50391912
PNG
(CHEMBL2147552)
Show SMILES Cc1cnccc1-c1cc2cnccc2c(NCC(C)(C)N)n1
Show InChI InChI=1S/C18H21N5/c1-12-9-20-6-4-14(12)16-8-13-10-21-7-5-15(13)17(23-16)22-11-18(2,3)19/h4-10H,11,19H2,1-3H3,(H,22,23)
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n/an/a 738n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCtheta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50391905
PNG
(CHEMBL2147545)
Show SMILES OCCNc1nc(cc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C15H14N4O/c20-8-7-18-15-13-3-6-17-10-12(13)9-14(19-15)11-1-4-16-5-2-11/h1-6,9-10,20H,7-8H2,(H,18,19)
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n/an/a 743n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCtheta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C eta type


(Homo sapiens (Human))
BDBM50391892
PNG
(CHEMBL2147531)
Show SMILES NCCNc1nc(cc2ccccc12)-c1ccncc1
Show InChI InChI=1S/C16H16N4/c17-7-10-19-16-14-4-2-1-3-13(14)11-15(20-16)12-5-8-18-9-6-12/h1-6,8-9,11H,7,10,17H2,(H,19,20)
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n/an/a 743n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCeta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity ass...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM50391903
PNG
(CHEMBL2147543)
Show SMILES NC1CCCN(C1)c1nc(cc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C18H19N5/c19-15-2-1-9-23(12-15)18-16-5-8-21-11-14(16)10-17(22-18)13-3-6-20-7-4-13/h3-8,10-11,15H,1-2,9,12,19H2
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n/an/a 771n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCalpha assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM50391904
PNG
(CHEMBL2147544)
Show SMILES NCCCNc1nc(cc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C16H17N5/c17-5-1-6-20-16-14-4-9-19-11-13(14)10-15(21-16)12-2-7-18-8-3-12/h2-4,7-11H,1,5-6,17H2,(H,20,21)
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n/an/a 779n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCbeta1 assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C epsilon type


(Homo sapiens (Human))
BDBM50391906
PNG
(CHEMBL2147546)
Show SMILES O=C1CN(CCN1)c1nc(cc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C17H15N5O/c23-16-11-22(8-7-20-16)17-14-3-6-19-10-13(14)9-15(21-17)12-1-4-18-5-2-12/h1-6,9-10H,7-8,11H2,(H,20,23)
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n/an/a 802n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCepsilon assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM50391899
PNG
(CHEMBL2147539)
Show SMILES NC(CNc1nc(cc2cnccc12)-c1ccncc1)Cc1ccccc1
Show InChI InChI=1S/C22H21N5/c23-19(12-16-4-2-1-3-5-16)15-26-22-20-8-11-25-14-18(20)13-21(27-22)17-6-9-24-10-7-17/h1-11,13-14,19H,12,15,23H2,(H,26,27)
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n/an/a 818n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCalpha assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM50324319
PNG
(1-Piperazin-1-yl-3-pyridin-4-yl[2,6]naphthyridine ...)
Show SMILES C1CN(CCN1)c1nc(cc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C17H17N5/c1-4-18-5-2-13(1)16-11-14-12-20-6-3-15(14)17(21-16)22-9-7-19-8-10-22/h1-6,11-12,19H,7-10H2
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n/an/a 823n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCbeta1 assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM50391897
PNG
(CHEMBL2147537)
Show SMILES C[C@H](N)CNc1nc(cc2cnccc12)-c1ccncc1 |r|
Show InChI InChI=1S/C16H17N5/c1-11(17)9-20-16-14-4-7-19-10-13(14)8-15(21-16)12-2-5-18-6-3-12/h2-8,10-11H,9,17H2,1H3,(H,20,21)/t11-/m0/s1
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n/an/a 829n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCalpha assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM50324316
PNG
(CHEMBL1214929 | N*1*-(3-Pyridin-4-yl[2,6]naphthyri...)
Show SMILES NCCNc1nc(cc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C15H15N5/c16-4-8-19-15-13-3-7-18-10-12(13)9-14(20-15)11-1-5-17-6-2-11/h1-3,5-7,9-10H,4,8,16H2,(H,19,20)
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n/an/a 859n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCbeta1 assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C eta type


(Homo sapiens (Human))
BDBM50391909
PNG
(CHEMBL2147549)
Show SMILES CC(C)Nc1cc(ccn1)-c1cc2cnccc2c(NCC(C)(C)N)n1
Show InChI InChI=1S/C20H26N6/c1-13(2)25-18-10-14(5-8-23-18)17-9-15-11-22-7-6-16(15)19(26-17)24-12-20(3,4)21/h5-11,13H,12,21H2,1-4H3,(H,23,25)(H,24,26)
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n/an/a 862n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCeta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity ass...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM50391903
PNG
(CHEMBL2147543)
Show SMILES NC1CCCN(C1)c1nc(cc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C18H19N5/c19-15-2-1-9-23(12-15)18-16-5-8-21-11-14(16)10-17(22-18)13-3-6-20-7-4-13/h3-8,10-11,15H,1-2,9,12,19H2
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n/an/a 865n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCbeta1 assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C epsilon type


(Homo sapiens (Human))
BDBM50391892
PNG
(CHEMBL2147531)
Show SMILES NCCNc1nc(cc2ccccc12)-c1ccncc1
Show InChI InChI=1S/C16H16N4/c17-7-10-19-16-14-4-2-1-3-13(14)11-15(20-16)12-5-8-18-9-6-12/h1-6,8-9,11H,7,10,17H2,(H,19,20)
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n/an/a 877n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCepsilon assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM50324316
PNG
(CHEMBL1214929 | N*1*-(3-Pyridin-4-yl[2,6]naphthyri...)
Show SMILES NCCNc1nc(cc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C15H15N5/c16-4-8-19-15-13-3-7-18-10-12(13)9-14(20-15)11-1-5-17-6-2-11/h1-3,5-7,9-10H,4,8,16H2,(H,19,20)
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n/an/a 900n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCalpha assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C epsilon type


(Homo sapiens (Human))
BDBM50391893
PNG
(CHEMBL2147532)
Show SMILES NCCNc1nc(cc2ncccc12)-c1ccncc1
Show InChI InChI=1S/C15H15N5/c16-5-9-19-15-12-2-1-6-18-14(12)10-13(20-15)11-3-7-17-8-4-11/h1-4,6-8,10H,5,9,16H2,(H,19,20)
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n/an/a 929n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCepsilon assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM50391899
PNG
(CHEMBL2147539)
Show SMILES NC(CNc1nc(cc2cnccc12)-c1ccncc1)Cc1ccccc1
Show InChI InChI=1S/C22H21N5/c23-19(12-16-4-2-1-3-5-16)15-26-22-20-8-11-25-14-18(20)13-21(27-22)17-6-9-24-10-7-17/h1-11,13-14,19H,12,15,23H2,(H,26,27)
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n/an/a 932n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCdelta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM50391898
PNG
(CHEMBL2147538)
Show SMILES CC(C)(N)CNc1nc(cc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C17H19N5/c1-17(2,18)11-21-16-14-5-8-20-10-13(14)9-15(22-16)12-3-6-19-7-4-12/h3-10H,11,18H2,1-2H3,(H,21,22)
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n/an/a 942n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCbeta1 assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50391896
PNG
(CHEMBL2147536)
Show SMILES NCCOc1nc(cc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C15H14N4O/c16-4-8-20-15-13-3-7-18-10-12(13)9-14(19-15)11-1-5-17-6-2-11/h1-3,5-7,9-10H,4,8,16H2
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n/an/a 948n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCtheta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM50391910
PNG
(CHEMBL2147550)
Show SMILES CC(C)(N)CNc1nc(cc2cnccc12)-c1ccncc1F
Show InChI InChI=1S/C17H18FN5/c1-17(2,19)10-22-16-12-3-5-20-8-11(12)7-15(23-16)13-4-6-21-9-14(13)18/h3-9H,10,19H2,1-2H3,(H,22,23)
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n/an/a 961n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCbeta1 assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM50391898
PNG
(CHEMBL2147538)
Show SMILES CC(C)(N)CNc1nc(cc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C17H19N5/c1-17(2,18)11-21-16-14-5-8-20-10-13(14)9-15(22-16)12-3-6-19-7-4-12/h3-10H,11,18H2,1-2H3,(H,21,22)
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n/an/a 967n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCalpha assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50391901
PNG
(CHEMBL2147541)
Show SMILES CNCCNc1nc(cc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C16H17N5/c1-17-8-9-20-16-14-4-7-19-11-13(14)10-15(21-16)12-2-5-18-6-3-12/h2-7,10-11,17H,8-9H2,1H3,(H,20,21)
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n/an/a 997n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCtheta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50391891
PNG
(CHEMBL2147533)
Show SMILES NCCNc1nc(cc2ccncc12)-c1ccncc1
Show InChI InChI=1S/C15H15N5/c16-4-8-19-15-13-10-18-7-3-12(13)9-14(20-15)11-1-5-17-6-2-11/h1-3,5-7,9-10H,4,8,16H2,(H,19,20)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCtheta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50391899
PNG
(CHEMBL2147539)
Show SMILES NC(CNc1nc(cc2cnccc12)-c1ccncc1)Cc1ccccc1
Show InChI InChI=1S/C22H21N5/c23-19(12-16-4-2-1-3-5-16)15-26-22-20-8-11-25-14-18(20)13-21(27-22)17-6-9-24-10-7-17/h1-11,13-14,19H,12,15,23H2,(H,26,27)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCtheta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM50391911
PNG
(CHEMBL2147551)
Show SMILES CC(C)(N)CNc1nc(cc2cnccc12)-c1ccncc1Cl
Show InChI InChI=1S/C17H18ClN5/c1-17(2,19)10-22-16-12-3-5-20-8-11(12)7-15(23-16)13-4-6-21-9-14(13)18/h3-9H,10,19H2,1-2H3,(H,22,23)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCalpha assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM50391896
PNG
(CHEMBL2147536)
Show SMILES NCCOc1nc(cc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C15H14N4O/c16-4-8-20-15-13-3-7-18-10-12(13)9-14(19-15)11-1-5-17-6-2-11/h1-3,5-7,9-10H,4,8,16H2
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n/an/a>1.00E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCalpha assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C epsilon type


(Homo sapiens (Human))
BDBM50391909
PNG
(CHEMBL2147549)
Show SMILES CC(C)Nc1cc(ccn1)-c1cc2cnccc2c(NCC(C)(C)N)n1
Show InChI InChI=1S/C20H26N6/c1-13(2)25-18-10-14(5-8-23-18)17-9-15-11-22-7-6-16(15)19(26-17)24-12-20(3,4)21/h5-11,13H,12,21H2,1-4H3,(H,23,25)(H,24,26)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCepsilon assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM50391912
PNG
(CHEMBL2147552)
Show SMILES Cc1cnccc1-c1cc2cnccc2c(NCC(C)(C)N)n1
Show InChI InChI=1S/C18H21N5/c1-12-9-20-6-4-14(12)16-8-13-10-21-7-5-15(13)17(23-16)22-11-18(2,3)19/h4-10H,11,19H2,1-3H3,(H,22,23)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCalpha assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM50391895
PNG
(CHEMBL2147535 | US11458138, Example 313)
Show SMILES NCCNc1nc(nc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C14H14N6/c15-4-8-18-14-11-3-7-17-9-12(11)19-13(20-14)10-1-5-16-6-2-10/h1-3,5-7,9H,4,8,15H2,(H,18,19,20)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCbeta1 assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM50391908
PNG
(CHEMBL2147548)
Show SMILES CC(C)(N)CNc1nc(cc2cnccc12)-c1ccnc(N)c1
Show InChI InChI=1S/C17H20N6/c1-17(2,19)10-22-16-13-4-5-20-9-12(13)7-14(23-16)11-3-6-21-15(18)8-11/h3-9H,10,19H2,1-2H3,(H2,18,21)(H,22,23)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCbeta1 assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM50391906
PNG
(CHEMBL2147546)
Show SMILES O=C1CN(CCN1)c1nc(cc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C17H15N5O/c23-16-11-22(8-7-20-16)17-14-3-6-19-10-13(14)9-15(21-17)12-1-4-18-5-2-12/h1-6,9-10H,7-8,11H2,(H,20,23)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCdelta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM50391907
PNG
(CHEMBL2147547)
Show SMILES CC(C)(N)CNc1nc(cc2cnccc12)-c1cccnc1
Show InChI InChI=1S/C17H19N5/c1-17(2,18)11-21-16-14-5-7-20-10-13(14)8-15(22-16)12-4-3-6-19-9-12/h3-10H,11,18H2,1-2H3,(H,21,22)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCdelta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C epsilon type


(Homo sapiens (Human))
BDBM50391907
PNG
(CHEMBL2147547)
Show SMILES CC(C)(N)CNc1nc(cc2cnccc12)-c1cccnc1
Show InChI InChI=1S/C17H19N5/c1-17(2,18)11-21-16-14-5-7-20-10-13(14)8-15(22-16)12-4-3-6-19-9-12/h3-10H,11,18H2,1-2H3,(H,21,22)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCepsilon assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50391895
PNG
(CHEMBL2147535 | US11458138, Example 313)
Show SMILES NCCNc1nc(nc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C14H14N6/c15-4-8-18-14-11-3-7-17-9-12(11)19-13(20-14)10-1-5-16-6-2-10/h1-3,5-7,9H,4,8,15H2,(H,18,19,20)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCtheta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM50391893
PNG
(CHEMBL2147532)
Show SMILES NCCNc1nc(cc2ncccc12)-c1ccncc1
Show InChI InChI=1S/C15H15N5/c16-5-9-19-15-12-2-1-6-18-14(12)10-13(20-15)11-3-7-17-8-4-11/h1-4,6-8,10H,5,9,16H2,(H,19,20)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCalpha assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM50391905
PNG
(CHEMBL2147545)
Show SMILES OCCNc1nc(cc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C15H14N4O/c20-8-7-18-15-13-3-6-17-10-12(13)9-14(19-15)11-1-4-16-5-2-11/h1-6,9-10,20H,7-8H2,(H,18,19)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCbeta1 assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM50391912
PNG
(CHEMBL2147552)
Show SMILES Cc1cnccc1-c1cc2cnccc2c(NCC(C)(C)N)n1
Show InChI InChI=1S/C18H21N5/c1-12-9-20-6-4-14(12)16-8-13-10-21-7-5-15(13)17(23-16)22-11-18(2,3)19/h4-10H,11,19H2,1-3H3,(H,22,23)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCbeta1 assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM50391893
PNG
(CHEMBL2147532)
Show SMILES NCCNc1nc(cc2ncccc12)-c1ccncc1
Show InChI InChI=1S/C15H15N5/c16-5-9-19-15-12-2-1-6-18-14(12)10-13(20-15)11-3-7-17-8-4-11/h1-4,6-8,10H,5,9,16H2,(H,19,20)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCbeta1 assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM50391901
PNG
(CHEMBL2147541)
Show SMILES CNCCNc1nc(cc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C16H17N5/c1-17-8-9-20-16-14-4-7-19-11-13(14)10-15(21-16)12-2-5-18-6-3-12/h2-7,10-11,17H,8-9H2,1H3,(H,20,21)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCalpha assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM50391891
PNG
(CHEMBL2147533)
Show SMILES NCCNc1nc(cc2ccncc12)-c1ccncc1
Show InChI InChI=1S/C15H15N5/c16-4-8-19-15-13-10-18-7-3-12(13)9-14(20-15)11-1-5-17-6-2-11/h1-3,5-7,9-10H,4,8,16H2,(H,19,20)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCalpha assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM50324319
PNG
(1-Piperazin-1-yl-3-pyridin-4-yl[2,6]naphthyridine ...)
Show SMILES C1CN(CCN1)c1nc(cc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C17H17N5/c1-4-18-5-2-13(1)16-11-14-12-20-6-3-15(14)17(21-16)22-9-7-19-8-10-22/h1-6,11-12,19H,7-10H2
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n/an/a>1.00E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCalpha assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM50391910
PNG
(CHEMBL2147550)
Show SMILES CC(C)(N)CNc1nc(cc2cnccc12)-c1ccncc1F
Show InChI InChI=1S/C17H18FN5/c1-17(2,19)10-22-16-12-3-5-20-8-11(12)7-15(23-16)13-4-6-21-9-14(13)18/h3-9H,10,19H2,1-2H3,(H,22,23)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCalpha assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM50391900
PNG
(CHEMBL2147540)
Show SMILES CN(CCN)c1nc(cc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C16H17N5/c1-21(9-5-17)16-14-4-8-19-11-13(14)10-15(20-16)12-2-6-18-7-3-12/h2-4,6-8,10-11H,5,9,17H2,1H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCbeta1 assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM50391907
PNG
(CHEMBL2147547)
Show SMILES CC(C)(N)CNc1nc(cc2cnccc12)-c1cccnc1
Show InChI InChI=1S/C17H19N5/c1-17(2,18)11-21-16-14-5-7-20-10-13(14)8-15(22-16)12-4-3-6-19-9-12/h3-10H,11,18H2,1-2H3,(H,21,22)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCbeta1 assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM50391909
PNG
(CHEMBL2147549)
Show SMILES CC(C)Nc1cc(ccn1)-c1cc2cnccc2c(NCC(C)(C)N)n1
Show InChI InChI=1S/C20H26N6/c1-13(2)25-18-10-14(5-8-23-18)17-9-15-11-22-7-6-16(15)19(26-17)24-12-20(3,4)21/h5-11,13H,12,21H2,1-4H3,(H,23,25)(H,24,26)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCdelta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50391893
PNG
(CHEMBL2147532)
Show SMILES NCCNc1nc(cc2ncccc12)-c1ccncc1
Show InChI InChI=1S/C15H15N5/c16-5-9-19-15-12-2-1-6-18-14(12)10-13(20-15)11-3-7-17-8-4-11/h1-4,6-8,10H,5,9,16H2,(H,19,20)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCtheta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM50391892
PNG
(CHEMBL2147531)
Show SMILES NCCNc1nc(cc2ccccc12)-c1ccncc1
Show InChI InChI=1S/C16H16N4/c17-7-10-19-16-14-4-2-1-3-13(14)11-15(20-16)12-5-8-18-9-6-12/h1-6,8-9,11H,7,10,17H2,(H,19,20)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCbeta1 assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM50391907
PNG
(CHEMBL2147547)
Show SMILES CC(C)(N)CNc1nc(cc2cnccc12)-c1cccnc1
Show InChI InChI=1S/C17H19N5/c1-17(2,18)11-21-16-14-5-7-20-10-13(14)8-15(22-16)12-4-3-6-19-9-12/h3-10H,11,18H2,1-2H3,(H,21,22)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCalpha assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM50391909
PNG
(CHEMBL2147549)
Show SMILES CC(C)Nc1cc(ccn1)-c1cc2cnccc2c(NCC(C)(C)N)n1
Show InChI InChI=1S/C20H26N6/c1-13(2)25-18-10-14(5-8-23-18)17-9-15-11-22-7-6-16(15)19(26-17)24-12-20(3,4)21/h5-11,13H,12,21H2,1-4H3,(H,23,25)(H,24,26)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCalpha assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM50391892
PNG
(CHEMBL2147531)
Show SMILES NCCNc1nc(cc2ccccc12)-c1ccncc1
Show InChI InChI=1S/C16H16N4/c17-7-10-19-16-14-4-2-1-3-13(14)11-15(20-16)12-5-8-18-9-6-12/h1-6,8-9,11H,7,10,17H2,(H,19,20)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCalpha assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM50391893
PNG
(CHEMBL2147532)
Show SMILES NCCNc1nc(cc2ncccc12)-c1ccncc1
Show InChI InChI=1S/C15H15N5/c16-5-9-19-15-12-2-1-6-18-14(12)10-13(20-15)11-3-7-17-8-4-11/h1-4,6-8,10H,5,9,16H2,(H,19,20)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCdelta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C epsilon type


(Homo sapiens (Human))
BDBM50391891
PNG
(CHEMBL2147533)
Show SMILES NCCNc1nc(cc2ccncc12)-c1ccncc1
Show InChI InChI=1S/C15H15N5/c16-4-8-19-15-13-10-18-7-3-12(13)9-14(20-15)11-1-5-17-6-2-11/h1-3,5-7,9-10H,4,8,16H2,(H,19,20)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCepsilon assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50391907
PNG
(CHEMBL2147547)
Show SMILES CC(C)(N)CNc1nc(cc2cnccc12)-c1cccnc1
Show InChI InChI=1S/C17H19N5/c1-17(2,18)11-21-16-14-5-7-20-10-13(14)8-15(22-16)12-4-3-6-19-9-12/h3-10H,11,18H2,1-2H3,(H,21,22)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCtheta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50391909
PNG
(CHEMBL2147549)
Show SMILES CC(C)Nc1cc(ccn1)-c1cc2cnccc2c(NCC(C)(C)N)n1
Show InChI InChI=1S/C20H26N6/c1-13(2)25-18-10-14(5-8-23-18)17-9-15-11-22-7-6-16(15)19(26-17)24-12-20(3,4)21/h5-11,13H,12,21H2,1-4H3,(H,23,25)(H,24,26)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCtheta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM50391900
PNG
(CHEMBL2147540)
Show SMILES CN(CCN)c1nc(cc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C16H17N5/c1-21(9-5-17)16-14-4-8-19-11-13(14)10-15(20-16)12-2-6-18-7-3-12/h2-4,6-8,10-11H,5,9,17H2,1H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCalpha assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C eta type


(Homo sapiens (Human))
BDBM50391891
PNG
(CHEMBL2147533)
Show SMILES NCCNc1nc(cc2ccncc12)-c1ccncc1
Show InChI InChI=1S/C15H15N5/c16-4-8-19-15-13-10-18-7-3-12(13)9-14(20-15)11-1-5-17-6-2-11/h1-3,5-7,9-10H,4,8,16H2,(H,19,20)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCeta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity ass...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM50391899
PNG
(CHEMBL2147539)
Show SMILES NC(CNc1nc(cc2cnccc12)-c1ccncc1)Cc1ccccc1
Show InChI InChI=1S/C22H21N5/c23-19(12-16-4-2-1-3-5-16)15-26-22-20-8-11-25-14-18(20)13-21(27-22)17-6-9-24-10-7-17/h1-11,13-14,19H,12,15,23H2,(H,26,27)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCbeta1 assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM50391901
PNG
(CHEMBL2147541)
Show SMILES CNCCNc1nc(cc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C16H17N5/c1-17-8-9-20-16-14-4-7-19-11-13(14)10-15(21-16)12-2-5-18-6-3-12/h2-7,10-11,17H,8-9H2,1H3,(H,20,21)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCbeta1 assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM50391892
PNG
(CHEMBL2147531)
Show SMILES NCCNc1nc(cc2ccccc12)-c1ccncc1
Show InChI InChI=1S/C16H16N4/c17-7-10-19-16-14-4-2-1-3-13(14)11-15(20-16)12-5-8-18-9-6-12/h1-6,8-9,11H,7,10,17H2,(H,19,20)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCdelta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM50391891
PNG
(CHEMBL2147533)
Show SMILES NCCNc1nc(cc2ccncc12)-c1ccncc1
Show InChI InChI=1S/C15H15N5/c16-4-8-19-15-13-10-18-7-3-12(13)9-14(20-15)11-1-5-17-6-2-11/h1-3,5-7,9-10H,4,8,16H2,(H,19,20)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCdelta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50391892
PNG
(CHEMBL2147531)
Show SMILES NCCNc1nc(cc2ccccc12)-c1ccncc1
Show InChI InChI=1S/C16H16N4/c17-7-10-19-16-14-4-2-1-3-13(14)11-15(20-16)12-5-8-18-9-6-12/h1-6,8-9,11H,7,10,17H2,(H,19,20)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCtheta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM50391891
PNG
(CHEMBL2147533)
Show SMILES NCCNc1nc(cc2ccncc12)-c1ccncc1
Show InChI InChI=1S/C15H15N5/c16-4-8-19-15-13-10-18-7-3-12(13)9-14(20-15)11-1-5-17-6-2-11/h1-3,5-7,9-10H,4,8,16H2,(H,19,20)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCbeta1 assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM50391905
PNG
(CHEMBL2147545)
Show SMILES OCCNc1nc(cc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C15H14N4O/c20-8-7-18-15-13-3-6-17-10-12(13)9-14(19-15)11-1-4-16-5-2-11/h1-6,9-10,20H,7-8H2,(H,18,19)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCalpha assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C eta type


(Homo sapiens (Human))
BDBM50391907
PNG
(CHEMBL2147547)
Show SMILES CC(C)(N)CNc1nc(cc2cnccc12)-c1cccnc1
Show InChI InChI=1S/C17H19N5/c1-17(2,18)11-21-16-14-5-7-20-10-13(14)8-15(22-16)12-4-3-6-19-9-12/h3-10H,11,18H2,1-2H3,(H,21,22)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCeta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity ass...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM50391895
PNG
(CHEMBL2147535 | US11458138, Example 313)
Show SMILES NCCNc1nc(nc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C14H14N6/c15-4-8-18-14-11-3-7-17-9-12(11)19-13(20-14)10-1-5-16-6-2-10/h1-3,5-7,9H,4,8,15H2,(H,18,19,20)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCalpha assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM50391894
PNG
(CHEMBL2147534)
Show SMILES NCCNc1cc(cc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C16H16N4/c17-4-8-20-16-10-13(12-1-5-18-6-2-12)9-14-11-19-7-3-15(14)16/h1-3,5-7,9-11,20H,4,8,17H2
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n/an/a>1.00E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCbeta1 assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM50391909
PNG
(CHEMBL2147549)
Show SMILES CC(C)Nc1cc(ccn1)-c1cc2cnccc2c(NCC(C)(C)N)n1
Show InChI InChI=1S/C20H26N6/c1-13(2)25-18-10-14(5-8-23-18)17-9-15-11-22-7-6-16(15)19(26-17)24-12-20(3,4)21/h5-11,13H,12,21H2,1-4H3,(H,23,25)(H,24,26)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCbeta1 assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50391906
PNG
(CHEMBL2147546)
Show SMILES O=C1CN(CCN1)c1nc(cc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C17H15N5O/c23-16-11-22(8-7-20-16)17-14-3-6-19-10-13(14)9-15(21-17)12-1-4-18-5-2-12/h1-6,9-10H,7-8,11H2,(H,20,23)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCtheta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM50391906
PNG
(CHEMBL2147546)
Show SMILES O=C1CN(CCN1)c1nc(cc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C17H15N5O/c23-16-11-22(8-7-20-16)17-14-3-6-19-10-13(14)9-15(21-17)12-1-4-18-5-2-12/h1-6,9-10H,7-8,11H2,(H,20,23)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCalpha assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM50391894
PNG
(CHEMBL2147534)
Show SMILES NCCNc1cc(cc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C16H16N4/c17-4-8-20-16-10-13(12-1-5-18-6-2-12)9-14-11-19-7-3-15(14)16/h1-3,5-7,9-11,20H,4,8,17H2
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n/an/a>1.00E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCalpha assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM50391896
PNG
(CHEMBL2147536)
Show SMILES NCCOc1nc(cc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C15H14N4O/c16-4-8-20-15-13-3-7-18-10-12(13)9-14(19-15)11-1-5-17-6-2-11/h1-3,5-7,9-10H,4,8,16H2
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n/an/a>1.00E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCbeta1 assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM50391906
PNG
(CHEMBL2147546)
Show SMILES O=C1CN(CCN1)c1nc(cc2cnccc12)-c1ccncc1
Show InChI InChI=1S/C17H15N5O/c23-16-11-22(8-7-20-16)17-14-3-6-19-10-13(14)9-15(21-17)12-1-4-18-5-2-12/h1-6,9-10H,7-8,11H2,(H,20,23)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCbeta1 assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Protein kinase C beta type


(Homo sapiens (Human))
BDBM50391911
PNG
(CHEMBL2147551)
Show SMILES CC(C)(N)CNc1nc(cc2cnccc12)-c1ccncc1Cl
Show InChI InChI=1S/C17H18ClN5/c1-17(2,19)10-22-16-12-3-5-20-8-11(12)7-15(23-16)13-4-6-21-9-14(13)18/h3-9H,10,19H2,1-2H3,(H,22,23)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKCbeta1 assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Cytochrome P450 1A2


(Homo sapiens (Human))
BDBM50391897
PNG
(CHEMBL2147537)
Show SMILES C[C@H](N)CNc1nc(cc2cnccc12)-c1ccncc1 |r|
Show InChI InChI=1S/C16H17N5/c1-11(17)9-20-16-14-4-7-19-10-13(14)8-15(21-16)12-2-5-18-6-3-12/h2-8,10-11H,9,17H2,1H3,(H,20,21)/t11-/m0/s1
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n/an/a 2.40E+3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of CYP1A2


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50391897
PNG
(CHEMBL2147537)
Show SMILES C[C@H](N)CNc1nc(cc2cnccc12)-c1ccncc1 |r|
Show InChI InChI=1S/C16H17N5/c1-11(17)9-20-16-14-4-7-19-10-13(14)8-15(21-16)12-2-5-18-6-3-12/h2-8,10-11H,9,17H2,1H3,(H,20,21)/t11-/m0/s1
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n/an/a>3.00E+4n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Displacement of [3H]dofetilide from human ERG expressed in HEK293 cells


Bioorg Med Chem Lett 21: 7367-72 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.025
BindingDB Entry DOI: 10.7270/Q22J6CZ4
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%