Found 30 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50359779
(CHEMBL1928271)Show SMILES CCN1CCN(CC1)S(=O)(=O)c1cnc(OCC2CC2)c(c1)-c1nc2c(CC)n(CCN3CCOCC3)nc2c(=O)[nH]1 Show InChI InChI=1S/C28H40N8O5S/c1-3-23-24-25(32-36(23)12-9-34-13-15-40-16-14-34)27(37)31-26(30-24)22-17-21(18-29-28(22)41-19-20-5-6-20)42(38,39)35-10-7-33(4-2)8-11-35/h17-18,20H,3-16,19H2,1-2H3,(H,30,31,37) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.260 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting method |
Bioorg Med Chem 20: 498-509 (2011)
Article DOI: 10.1016/j.bmc.2011.10.022
BindingDB Entry DOI: 10.7270/Q2M9094T |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50359773
(CHEMBL1928265)Show SMILES CCCCOc1ncc(cc1-c1nc2c(CC)n(nc2c(=O)[nH]1)C1CCN(CC1)S(C)(=O)=O)S(=O)(=O)N1CCN(CC)CC1 Show InChI InChI=1S/C28H42N8O6S2/c1-5-8-17-42-28-22(18-21(19-29-28)44(40,41)35-15-13-33(7-3)14-16-35)26-30-24-23(6-2)36(32-25(24)27(37)31-26)20-9-11-34(12-10-20)43(4,38)39/h18-20H,5-17H2,1-4H3,(H,30,31,37) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 0.310 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting method |
Bioorg Med Chem 20: 498-509 (2011)
Article DOI: 10.1016/j.bmc.2011.10.022
BindingDB Entry DOI: 10.7270/Q2M9094T |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50359795
(CHEMBL1928258)Show SMILES CCCOc1ncc(cc1-c1nc2c(CC)n(CCOC)nc2c(=O)[nH]1)S(=O)(=O)N1CCN(CC)CC1 Show InChI InChI=1S/C24H35N7O5S/c1-5-13-36-24-18(15-17(16-25-24)37(33,34)30-10-8-29(7-3)9-11-30)22-26-20-19(6-2)31(12-14-35-4)28-21(20)23(32)27-22/h15-16H,5-14H2,1-4H3,(H,26,27,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.690 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting method |
Bioorg Med Chem 20: 498-509 (2011)
Article DOI: 10.1016/j.bmc.2011.10.022
BindingDB Entry DOI: 10.7270/Q2M9094T |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50359767
(CHEMBL1928259)Show SMILES CCN1CCN(CC1)S(=O)(=O)c1cnc(OCC(C)C)c(c1)-c1nc2c(CC)n(CCOC)nc2c(=O)[nH]1 Show InChI InChI=1S/C25H37N7O5S/c1-6-20-21-22(29-32(20)12-13-36-5)24(33)28-23(27-21)19-14-18(15-26-25(19)37-16-17(3)4)38(34,35)31-10-8-30(7-2)9-11-31/h14-15,17H,6-13,16H2,1-5H3,(H,27,28,33) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.690 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting method |
Bioorg Med Chem 20: 498-509 (2011)
Article DOI: 10.1016/j.bmc.2011.10.022
BindingDB Entry DOI: 10.7270/Q2M9094T |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50359774
(CHEMBL1928266)Show SMILES CCCCOc1ncc(cc1-c1nc2c(CC)n(nc2c(=O)[nH]1)C1CCN(C)CC1)S(=O)(=O)N1CCN(CC)CC1 Show InChI InChI=1S/C28H42N8O4S/c1-5-8-17-40-28-22(18-21(19-29-28)41(38,39)35-15-13-34(7-3)14-16-35)26-30-24-23(6-2)36(32-25(24)27(37)31-26)20-9-11-33(4)12-10-20/h18-20H,5-17H2,1-4H3,(H,30,31,37) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.740 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting method |
Bioorg Med Chem 20: 498-509 (2011)
Article DOI: 10.1016/j.bmc.2011.10.022
BindingDB Entry DOI: 10.7270/Q2M9094T |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50359768
(CHEMBL1928260)Show SMILES CCN1CCN(CC1)S(=O)(=O)c1cnc(OCc2ccccn2)c(c1)-c1nc2c(CC)n(CCOC)nc2c(=O)[nH]1 Show InChI InChI=1S/C27H34N8O5S/c1-4-22-23-24(32-35(22)14-15-39-3)26(36)31-25(30-23)21-16-20(41(37,38)34-12-10-33(5-2)11-13-34)17-29-27(21)40-18-19-8-6-7-9-28-19/h6-9,16-17H,4-5,10-15,18H2,1-3H3,(H,30,31,36) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.75 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting method |
Bioorg Med Chem 20: 498-509 (2011)
Article DOI: 10.1016/j.bmc.2011.10.022
BindingDB Entry DOI: 10.7270/Q2M9094T |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50359777
(CHEMBL1928269)Show SMILES CCCCOc1ncc(cc1-c1nc2c(CC)n(nc2c(=O)[nH]1)C1CN(C)C1)S(=O)(=O)N1CCN(CC)CC1 Show InChI InChI=1S/C26H38N8O4S/c1-5-8-13-38-26-20(14-19(15-27-26)39(36,37)33-11-9-32(7-3)10-12-33)24-28-22-21(6-2)34(18-16-31(4)17-18)30-23(22)25(35)29-24/h14-15,18H,5-13,16-17H2,1-4H3,(H,28,29,35) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.780 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting method |
Bioorg Med Chem 20: 498-509 (2011)
Article DOI: 10.1016/j.bmc.2011.10.022
BindingDB Entry DOI: 10.7270/Q2M9094T |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50359778
(CHEMBL1928270)Show SMILES CCOc1ncc(cc1-c1nc2c(CC)n(CCN3CCOCC3)nc2c(=O)[nH]1)S(=O)(=O)N1CCN(CC)CC1 Show InChI InChI=1S/C26H38N8O5S/c1-4-21-22-23(30-34(21)12-9-32-13-15-38-16-14-32)25(35)29-24(28-22)20-17-19(18-27-26(20)39-6-3)40(36,37)33-10-7-31(5-2)8-11-33/h17-18H,4-16H2,1-3H3,(H,28,29,35) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.860 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting method |
Bioorg Med Chem 20: 498-509 (2011)
Article DOI: 10.1016/j.bmc.2011.10.022
BindingDB Entry DOI: 10.7270/Q2M9094T |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50359789
(CHEMBL1928252)Show SMILES CCN1CCN(CC1)S(=O)(=O)c1cnc(OCCOC)c(c1)-c1nc2c(CC)n(CC(C)C)nc2c(=O)[nH]1 Show InChI InChI=1S/C25H37N7O5S/c1-6-20-21-22(29-32(20)16-17(3)4)24(33)28-23(27-21)19-14-18(15-26-25(19)37-13-12-36-5)38(34,35)31-10-8-30(7-2)9-11-31/h14-15,17H,6-13,16H2,1-5H3,(H,27,28,33) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting method |
Bioorg Med Chem 20: 498-509 (2011)
Article DOI: 10.1016/j.bmc.2011.10.022
BindingDB Entry DOI: 10.7270/Q2M9094T |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50359771
(CHEMBL1928263)Show SMILES CCCCOc1ncc(cc1-c1nc2c(CC)n(CCN(C)C)nc2c(=O)[nH]1)S(=O)(=O)N1CCN(CC)CC1 Show InChI InChI=1S/C26H40N8O4S/c1-6-9-16-38-26-20(17-19(18-27-26)39(36,37)33-13-11-32(8-3)12-14-33)24-28-22-21(7-2)34(15-10-31(4)5)30-23(22)25(35)29-24/h17-18H,6-16H2,1-5H3,(H,28,29,35) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting method |
Bioorg Med Chem 20: 498-509 (2011)
Article DOI: 10.1016/j.bmc.2011.10.022
BindingDB Entry DOI: 10.7270/Q2M9094T |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50359790
(CHEMBL1928253)Show SMILES CCN1CCN(CC1)S(=O)(=O)c1cnc(OCCOC)c(c1)-c1nc2c(CC)n(CC3CC3)nc2c(=O)[nH]1 Show InChI InChI=1S/C25H35N7O5S/c1-4-20-21-22(29-32(20)16-17-6-7-17)24(33)28-23(27-21)19-14-18(15-26-25(19)37-13-12-36-3)38(34,35)31-10-8-30(5-2)9-11-31/h14-15,17H,4-13,16H2,1-3H3,(H,27,28,33) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting method |
Bioorg Med Chem 20: 498-509 (2011)
Article DOI: 10.1016/j.bmc.2011.10.022
BindingDB Entry DOI: 10.7270/Q2M9094T |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50246483
(3-ethyl-5-(5-(4-ethylpiperazin-1-ylsulfonyl)-2-pro...)Show SMILES CCCOc1ncc(cc1-c1nc2c(CC)n(Cc3ccccn3)nc2c(=O)[nH]1)S(=O)(=O)N1CCN(CC)CC1 Show InChI InChI=1S/C27H34N8O4S/c1-4-15-39-27-21(16-20(17-29-27)40(37,38)34-13-11-33(6-3)12-14-34)25-30-23-22(5-2)35(32-24(23)26(36)31-25)18-19-9-7-8-10-28-19/h7-10,16-17H,4-6,11-15,18H2,1-3H3,(H,30,31,36) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting method |
Bioorg Med Chem 20: 498-509 (2011)
Article DOI: 10.1016/j.bmc.2011.10.022
BindingDB Entry DOI: 10.7270/Q2M9094T |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50359770
(CHEMBL1928262)Show SMILES CCOc1ncc(cc1-c1nc2c(CC)n(CCOC)nc2c(=O)[nH]1)S(=O)(=O)N1CCN(CC)CC1 Show InChI InChI=1S/C23H33N7O5S/c1-5-18-19-20(27-30(18)12-13-34-4)22(31)26-21(25-19)17-14-16(15-24-23(17)35-7-3)36(32,33)29-10-8-28(6-2)9-11-29/h14-15H,5-13H2,1-4H3,(H,25,26,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting method |
Bioorg Med Chem 20: 498-509 (2011)
Article DOI: 10.1016/j.bmc.2011.10.022
BindingDB Entry DOI: 10.7270/Q2M9094T |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50359780
(CHEMBL1928272)Show SMILES CCN1CCN(CC1)S(=O)(=O)c1cnc(OCCOC)c(c1)-c1nc2c(CC)n(CCN3CCOCC3)nc2c(=O)[nH]1 Show InChI InChI=1S/C27H40N8O6S/c1-4-22-23-24(31-35(22)11-8-33-12-14-40-15-13-33)26(36)30-25(29-23)21-18-20(19-28-27(21)41-17-16-39-3)42(37,38)34-9-6-32(5-2)7-10-34/h18-19H,4-17H2,1-3H3,(H,29,30,36) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting method |
Bioorg Med Chem 20: 498-509 (2011)
Article DOI: 10.1016/j.bmc.2011.10.022
BindingDB Entry DOI: 10.7270/Q2M9094T |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50359787
(CHEMBL1928250)Show SMILES CCN1CCN(CC1)S(=O)(=O)c1cnc(OCCOC)c(c1)-c1nc2c(CC)n(nc2c(=O)[nH]1)C(C)C Show InChI InChI=1S/C24H35N7O5S/c1-6-19-20-21(28-31(19)16(3)4)23(32)27-22(26-20)18-14-17(15-25-24(18)36-13-12-35-5)37(33,34)30-10-8-29(7-2)9-11-30/h14-16H,6-13H2,1-5H3,(H,26,27,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting method |
Bioorg Med Chem 20: 498-509 (2011)
Article DOI: 10.1016/j.bmc.2011.10.022
BindingDB Entry DOI: 10.7270/Q2M9094T |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50359769
(CHEMBL1928261)Show SMILES CCN1CCN(CC1)S(=O)(=O)c1cnc(OCCOC)c(c1)-c1nc2c(CC)n(CCOC)nc2c(=O)[nH]1 Show InChI InChI=1S/C24H35N7O6S/c1-5-19-20-21(28-31(19)11-12-35-3)23(32)27-22(26-20)18-15-17(16-25-24(18)37-14-13-36-4)38(33,34)30-9-7-29(6-2)8-10-30/h15-16H,5-14H2,1-4H3,(H,26,27,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting method |
Bioorg Med Chem 20: 498-509 (2011)
Article DOI: 10.1016/j.bmc.2011.10.022
BindingDB Entry DOI: 10.7270/Q2M9094T |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50359791
(CHEMBL1928254)Show SMILES CCN1CCN(CC1)S(=O)(=O)c1cnc(OCCOC)c(c1)-c1nc2c(CC)n(nc2c(=O)[nH]1)C1CCOCC1 Show InChI InChI=1S/C26H37N7O6S/c1-4-21-22-23(30-33(21)18-6-12-38-13-7-18)25(34)29-24(28-22)20-16-19(17-27-26(20)39-15-14-37-3)40(35,36)32-10-8-31(5-2)9-11-32/h16-18H,4-15H2,1-3H3,(H,28,29,34) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting method |
Bioorg Med Chem 20: 498-509 (2011)
Article DOI: 10.1016/j.bmc.2011.10.022
BindingDB Entry DOI: 10.7270/Q2M9094T |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50359786
(CHEMBL1928249)Show SMILES CCCn1nc2c(nc([nH]c2=O)-c2cc(cnc2OCCOC)S(=O)(=O)N2CCN(CC)CC2)c1CC Show InChI InChI=1S/C24H35N7O5S/c1-5-8-31-19(6-2)20-21(28-31)23(32)27-22(26-20)18-15-17(16-25-24(18)36-14-13-35-4)37(33,34)30-11-9-29(7-3)10-12-30/h15-16H,5-14H2,1-4H3,(H,26,27,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting method |
Bioorg Med Chem 20: 498-509 (2011)
Article DOI: 10.1016/j.bmc.2011.10.022
BindingDB Entry DOI: 10.7270/Q2M9094T |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50359788
(CHEMBL1928251)Show SMILES CCN1CCN(CC1)S(=O)(=O)c1cnc(OCCOC)c(c1)-c1nc2c(CC)n(nc2c(=O)[nH]1)C1CCC1 Show InChI InChI=1S/C25H35N7O5S/c1-4-20-21-22(29-32(20)17-7-6-8-17)24(33)28-23(27-21)19-15-18(16-26-25(19)37-14-13-36-3)38(34,35)31-11-9-30(5-2)10-12-31/h15-17H,4-14H2,1-3H3,(H,27,28,33) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting method |
Bioorg Med Chem 20: 498-509 (2011)
Article DOI: 10.1016/j.bmc.2011.10.022
BindingDB Entry DOI: 10.7270/Q2M9094T |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50359772
(CHEMBL1928264)Show SMILES CCN1CCN(CC1)S(=O)(=O)c1cnc(OCC(C)C)c(c1)-c1nc2c(CC)n(CCCN(C)C)nc2c(=O)[nH]1 Show InChI InChI=1S/C27H42N8O4S/c1-7-22-23-24(31-35(22)11-9-10-32(5)6)26(36)30-25(29-23)21-16-20(17-28-27(21)39-18-19(3)4)40(37,38)34-14-12-33(8-2)13-15-34/h16-17,19H,7-15,18H2,1-6H3,(H,29,30,36) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting method |
Bioorg Med Chem 20: 498-509 (2011)
Article DOI: 10.1016/j.bmc.2011.10.022
BindingDB Entry DOI: 10.7270/Q2M9094T |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50359782
(CHEMBL1928274)Show SMILES CCCOc1ncc(cc1-c1nc2c3CCCCn3nc2c(=O)[nH]1)S(=O)(=O)N1CCN(CC)CC1 Show InChI InChI=1S/C23H31N7O4S/c1-3-13-34-23-17(14-16(15-24-23)35(32,33)29-11-9-28(4-2)10-12-29)21-25-19-18-7-5-6-8-30(18)27-20(19)22(31)26-21/h14-15H,3-13H2,1-2H3,(H,25,26,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting method |
Bioorg Med Chem 20: 498-509 (2011)
Article DOI: 10.1016/j.bmc.2011.10.022
BindingDB Entry DOI: 10.7270/Q2M9094T |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50359785
(CHEMBL1928277)Show SMILES CCN1CCN(CC1)S(=O)(=O)c1cnc(OCCOC)c(c1)-c1nc2c3C(C)CCCn3nc2c(=O)[nH]1 Show InChI InChI=1S/C24H33N7O5S/c1-4-29-8-10-30(11-9-29)37(33,34)17-14-18(24(25-15-17)36-13-12-35-3)22-26-19-20(23(32)27-22)28-31-7-5-6-16(2)21(19)31/h14-16H,4-13H2,1-3H3,(H,26,27,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2.76 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting method |
Bioorg Med Chem 20: 498-509 (2011)
Article DOI: 10.1016/j.bmc.2011.10.022
BindingDB Entry DOI: 10.7270/Q2M9094T |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50359793
(CHEMBL1928256)Show SMILES CCc1n(CC(C)C)nc2c1nc([nH]c2=O)-c1cc(cnc1OCCOC)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C24H35N7O5S/c1-6-19-20-21(28-31(19)15-16(2)3)23(32)27-22(26-20)18-13-17(14-25-24(18)36-12-11-35-5)37(33,34)30-9-7-29(4)8-10-30/h13-14,16H,6-12,15H2,1-5H3,(H,26,27,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting method |
Bioorg Med Chem 20: 498-509 (2011)
Article DOI: 10.1016/j.bmc.2011.10.022
BindingDB Entry DOI: 10.7270/Q2M9094T |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM14390
(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)Show SMILES CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C22H30N6O4S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| MMDB
PDB
Article
PubMed
| n/a | n/a | 3.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting method |
Bioorg Med Chem 20: 498-509 (2011)
Article DOI: 10.1016/j.bmc.2011.10.022
BindingDB Entry DOI: 10.7270/Q2M9094T |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50359784
(CHEMBL1928276)Show SMILES CCOc1ncc(cc1-c1nc2c3C(C)CCCn3nc2c(=O)[nH]1)S(=O)(=O)N1CCN(CC)CC1 Show InChI InChI=1S/C23H31N7O4S/c1-4-28-9-11-29(12-10-28)35(32,33)16-13-17(23(24-14-16)34-5-2)21-25-18-19(22(31)26-21)27-30-8-6-7-15(3)20(18)30/h13-15H,4-12H2,1-3H3,(H,25,26,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 3.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting method |
Bioorg Med Chem 20: 498-509 (2011)
Article DOI: 10.1016/j.bmc.2011.10.022
BindingDB Entry DOI: 10.7270/Q2M9094T |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50359792
(CHEMBL1928255)Show SMILES CCCn1nc2c(nc([nH]c2=O)-c2cc(cnc2OCCOC)S(=O)(=O)N2CCN(C)CC2)c1CC Show InChI InChI=1S/C23H33N7O5S/c1-5-7-30-18(6-2)19-20(27-30)22(31)26-21(25-19)17-14-16(15-24-23(17)35-13-12-34-4)36(32,33)29-10-8-28(3)9-11-29/h14-15H,5-13H2,1-4H3,(H,25,26,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting method |
Bioorg Med Chem 20: 498-509 (2011)
Article DOI: 10.1016/j.bmc.2011.10.022
BindingDB Entry DOI: 10.7270/Q2M9094T |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50359776
(CHEMBL1928268)Show SMILES CCOc1ncc(cc1C(=O)Nc1c(CC)n(nc1C(N)=O)C1CN(C)C1)S(=O)(=O)N1CCN(CC)CC1 Show InChI InChI=1S/C24H36N8O5S/c1-5-19-20(21(22(25)33)28-32(19)16-14-29(4)15-16)27-23(34)18-12-17(13-26-24(18)37-7-3)38(35,36)31-10-8-30(6-2)9-11-31/h12-13,16H,5-11,14-15H2,1-4H3,(H2,25,33)(H,27,34) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 8.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting method |
Bioorg Med Chem 20: 498-509 (2011)
Article DOI: 10.1016/j.bmc.2011.10.022
BindingDB Entry DOI: 10.7270/Q2M9094T |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50359783
(CHEMBL1928275)Show SMILES CCN1CCN(CC1)S(=O)(=O)c1cnc(OCCOC)c(c1)-c1nc2c3CCCCn3nc2c(=O)[nH]1 Show InChI InChI=1S/C23H31N7O5S/c1-3-28-8-10-29(11-9-28)36(32,33)16-14-17(23(24-15-16)35-13-12-34-2)21-25-19-18-6-4-5-7-30(18)27-20(19)22(31)26-21/h14-15H,3-13H2,1-2H3,(H,25,26,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 8.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting method |
Bioorg Med Chem 20: 498-509 (2011)
Article DOI: 10.1016/j.bmc.2011.10.022
BindingDB Entry DOI: 10.7270/Q2M9094T |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50359781
(CHEMBL1928273)Show SMILES CCOc1ncc(cc1-c1nc2c3CCCCn3nc2c(=O)[nH]1)S(=O)(=O)N1CCN(CC)CC1 Show InChI InChI=1S/C22H29N7O4S/c1-3-27-9-11-28(12-10-27)34(31,32)15-13-16(22(23-14-15)33-4-2)20-24-18-17-7-5-6-8-29(17)26-19(18)21(30)25-20/h13-14H,3-12H2,1-2H3,(H,24,25,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting method |
Bioorg Med Chem 20: 498-509 (2011)
Article DOI: 10.1016/j.bmc.2011.10.022
BindingDB Entry DOI: 10.7270/Q2M9094T |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50359775
(CHEMBL1928267)Show SMILES CCOc1ncc(cc1C(=O)Nc1c(CC)n(nc1C(N)=O)C1CNC1)S(=O)(=O)N1CCN(CC)CC1 Show InChI InChI=1S/C23H34N8O5S/c1-4-18-19(20(21(24)32)28-31(18)15-12-25-13-15)27-22(33)17-11-16(14-26-23(17)36-6-3)37(34,35)30-9-7-29(5-2)8-10-30/h11,14-15,25H,4-10,12-13H2,1-3H3,(H2,24,32)(H,27,33) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting method |
Bioorg Med Chem 20: 498-509 (2011)
Article DOI: 10.1016/j.bmc.2011.10.022
BindingDB Entry DOI: 10.7270/Q2M9094T |
More data for this
Ligand-Target Pair | |
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