Affinity Data by PubMed id=22122563

PubMed code 22122563

Found 34 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Estrogen receptor beta (Rattus norvegicus)	BDBM50364076 (CHEMBL198159) Show SMILES Oc1ccc(C[C@@H](C#N)c2ccc(O)cc2)cc1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	0.270	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois Curated by ChEMBL					Assay Description Displacement of [3H]E2 from rat ERbeta1 after 90 mins				J Med Chem 55: 528-37 (2012) Article DOI: 10.1021/jm201436k BindingDB Entry DOI: 10.7270/Q2PN963M
University of Illinois Curated by ChEMBL					More data for this Ligand-Target Pair
Estrogen receptor beta (Rattus norvegicus)	BDBM50364075 (CHEMBL1950809) Show SMILES Oc1ccc(C[C@H](C#N)c2ccc(O)cc2)cc1 \|r\| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	1.82	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois Curated by ChEMBL					Assay Description Displacement of [3H]E2 from rat ERbeta1 after 90 mins				J Med Chem 55: 528-37 (2012) Article DOI: 10.1021/jm201436k BindingDB Entry DOI: 10.7270/Q2PN963M
University of Illinois Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Estrogen receptor (Homo sapiens (Human))	BDBM50364075 (CHEMBL1950809) Show SMILES Oc1ccc(C[C@H](C#N)c2ccc(O)cc2)cc1 \|r\| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a
University of Illinois Curated by ChEMBL					Assay Description Agonist activity at human N-His6-tagged terbium-labelled ERalpha ligand binding domain expressed in Escherichia coli BL21 cells assessed as recruitme...				J Med Chem 55: 528-37 (2012) Article DOI: 10.1021/jm201436k BindingDB Entry DOI: 10.7270/Q2PN963M
University of Illinois Curated by ChEMBL					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM50364076 (CHEMBL198159) Show SMILES Oc1ccc(C[C@@H](C#N)c2ccc(O)cc2)cc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	205	n/a	n/a	n/a	n/a
University of Illinois Curated by ChEMBL					Assay Description Agonist activity at human ERalpha expressed in U2OS cells coexpressing pCMX-hSRC3 assessed as luciferase activity after 24 hrs by reporter gene assay				J Med Chem 55: 528-37 (2012) Article DOI: 10.1021/jm201436k BindingDB Entry DOI: 10.7270/Q2PN963M
University of Illinois Curated by ChEMBL					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM17292 ((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	0.150	n/a	n/a	n/a	n/a
University of Illinois Curated by ChEMBL					Assay Description Agonist activity at human ERalpha expressed in U2OS cells coexpressing pCMX-hSRC3 assessed as luciferase activity after 24 hrs by reporter gene assay				J Med Chem 55: 528-37 (2012) Article DOI: 10.1021/jm201436k BindingDB Entry DOI: 10.7270/Q2PN963M
University of Illinois Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Estrogen receptor beta (Homo sapiens (Human))	BDBM17292 ((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	0.400	n/a	n/a	n/a	n/a
University of Illinois Curated by ChEMBL					Assay Description Agonist activity at human ERbeta expressed in U2OS cells coexpressing pCMX-hSRC3 assessed as luciferase activity after 24 hrs by reporter gene assay				J Med Chem 55: 528-37 (2012) Article DOI: 10.1021/jm201436k BindingDB Entry DOI: 10.7270/Q2PN963M
University of Illinois Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Estrogen receptor beta (Homo sapiens (Human))	BDBM50106635 ((+/-)-2,3-bis(4-hydroxyphenyl)propanenitrile \| 2,3...) Show SMILES Oc1ccc(CC(C#N)c2ccc(O)cc2)cc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	3.30	n/a	n/a	n/a	n/a
University of Illinois Curated by ChEMBL					Assay Description Agonist activity at human ERbeta expressed in HEC-1 cells coexpressing beta-gal assessed as luciferase activity after 24 hrs by reporter gene assay				J Med Chem 55: 528-37 (2012) Article DOI: 10.1021/jm201436k BindingDB Entry DOI: 10.7270/Q2PN963M
University of Illinois Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Estrogen receptor (Homo sapiens (Human))	BDBM50364076 (CHEMBL198159) Show SMILES Oc1ccc(C[C@@H](C#N)c2ccc(O)cc2)cc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.90	n/a	n/a	n/a	n/a
University of Illinois Curated by ChEMBL					Assay Description Agonist activity at human N-His6-tagged terbium-labelled NRID-SRC3 of ERalpha ligand binding domain expressed in Escherichia coli BL21 cells after 1 ...				J Med Chem 55: 528-37 (2012) Article DOI: 10.1021/jm201436k BindingDB Entry DOI: 10.7270/Q2PN963M
University of Illinois Curated by ChEMBL					More data for this Ligand-Target Pair
Estrogen receptor beta (Homo sapiens (Human))	BDBM50106635 ((+/-)-2,3-bis(4-hydroxyphenyl)propanenitrile \| 2,3...) Show SMILES Oc1ccc(CC(C#N)c2ccc(O)cc2)cc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	0.710	n/a	n/a	n/a	n/a
University of Illinois Curated by ChEMBL					Assay Description Agonist activity at human N-His6-tagged terbium-labelled NRID-SRC3 of ERbeta ligand binding domain expressed in Escherichia coli BL21 cells after 1 h...				J Med Chem 55: 528-37 (2012) Article DOI: 10.1021/jm201436k BindingDB Entry DOI: 10.7270/Q2PN963M
University of Illinois Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Estrogen receptor beta (Homo sapiens (Human))	BDBM17292 ((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	0.900	n/a	n/a	n/a	n/a
University of Illinois Curated by ChEMBL					Assay Description Agonist activity at human N-His6-tagged terbium-labelled NRID-SRC3 of ERbeta ligand binding domain expressed in Escherichia coli BL21 cells after 1 h...				J Med Chem 55: 528-37 (2012) Article DOI: 10.1021/jm201436k BindingDB Entry DOI: 10.7270/Q2PN963M
University of Illinois Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Estrogen receptor (Homo sapiens (Human))	BDBM50364076 (CHEMBL198159) Show SMILES Oc1ccc(C[C@@H](C#N)c2ccc(O)cc2)cc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	286	n/a	n/a	n/a	n/a
University of Illinois Curated by ChEMBL					Assay Description Agonist activity at human ERalpha expressed in HEC-1 cells coexpressing beta-gal assessed as luciferase activity after 24 hrs by reporter gene assay				J Med Chem 55: 528-37 (2012) Article DOI: 10.1021/jm201436k BindingDB Entry DOI: 10.7270/Q2PN963M
University of Illinois Curated by ChEMBL					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM50364076 (CHEMBL198159) Show SMILES Oc1ccc(C[C@@H](C#N)c2ccc(O)cc2)cc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	637	n/a	n/a	n/a	n/a
University of Illinois Curated by ChEMBL					Assay Description Agonist activity at human N-His6-tagged terbium-labelled ERalpha ligand binding domain expressed in Escherichia coli BL21 cells assessed as recruitme...				J Med Chem 55: 528-37 (2012) Article DOI: 10.1021/jm201436k BindingDB Entry DOI: 10.7270/Q2PN963M
University of Illinois Curated by ChEMBL					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM50106635 ((+/-)-2,3-bis(4-hydroxyphenyl)propanenitrile \| 2,3...) Show SMILES Oc1ccc(CC(C#N)c2ccc(O)cc2)cc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3.40	n/a	n/a	n/a	n/a
University of Illinois Curated by ChEMBL					Assay Description Agonist activity at human N-His6-tagged terbium-labelled NRID-SRC3 of ERalpha ligand binding domain expressed in Escherichia coli BL21 cells after 1 ...				J Med Chem 55: 528-37 (2012) Article DOI: 10.1021/jm201436k BindingDB Entry DOI: 10.7270/Q2PN963M
University of Illinois Curated by ChEMBL					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM50106635 ((+/-)-2,3-bis(4-hydroxyphenyl)propanenitrile \| 2,3...) Show SMILES Oc1ccc(CC(C#N)c2ccc(O)cc2)cc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	304	n/a	n/a	n/a	n/a
University of Illinois Curated by ChEMBL					Assay Description Agonist activity at human ERalpha expressed in HEC-1 cells coexpressing beta-gal assessed as luciferase activity after 24 hrs by reporter gene assay				J Med Chem 55: 528-37 (2012) Article DOI: 10.1021/jm201436k BindingDB Entry DOI: 10.7270/Q2PN963M
University of Illinois Curated by ChEMBL					More data for this Ligand-Target Pair
Estrogen receptor beta (Homo sapiens (Human))	BDBM50364076 (CHEMBL198159) Show SMILES Oc1ccc(C[C@@H](C#N)c2ccc(O)cc2)cc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	10.7	n/a	n/a	n/a	n/a
University of Illinois Curated by ChEMBL					Assay Description Agonist activity at human N-His6-tagged terbium-labelled ERbeta ligand binding domain expressed in Escherichia coli BL21 cells assessed as recruitmen...				J Med Chem 55: 528-37 (2012) Article DOI: 10.1021/jm201436k BindingDB Entry DOI: 10.7270/Q2PN963M
University of Illinois Curated by ChEMBL					More data for this Ligand-Target Pair
Estrogen receptor beta (Homo sapiens (Human))	BDBM17292 ((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	1.5	n/a	n/a	n/a	n/a
University of Illinois Curated by ChEMBL					Assay Description Agonist activity at human N-His6-tagged terbium-labelled ERbeta ligand binding domain expressed in Escherichia coli BL21 cells assessed as recruitmen...				J Med Chem 55: 528-37 (2012) Article DOI: 10.1021/jm201436k BindingDB Entry DOI: 10.7270/Q2PN963M
University of Illinois Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Estrogen receptor beta (Homo sapiens (Human))	BDBM50364075 (CHEMBL1950809) Show SMILES Oc1ccc(C[C@H](C#N)c2ccc(O)cc2)cc1 \|r\| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	0.760	n/a	n/a	n/a	n/a
University of Illinois Curated by ChEMBL					Assay Description Agonist activity at human N-His6-tagged terbium-labelled NRID-SRC3 of ERbeta ligand binding domain expressed in Escherichia coli BL21 cells after 1 h...				J Med Chem 55: 528-37 (2012) Article DOI: 10.1021/jm201436k BindingDB Entry DOI: 10.7270/Q2PN963M
University of Illinois Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Estrogen receptor beta (Homo sapiens (Human))	BDBM50364076 (CHEMBL198159) Show SMILES Oc1ccc(C[C@@H](C#N)c2ccc(O)cc2)cc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.800	n/a	n/a	n/a	n/a
University of Illinois Curated by ChEMBL					Assay Description Agonist activity at human N-His6-tagged terbium-labelled NRID-SRC3 of ERbeta ligand binding domain expressed in Escherichia coli BL21 cells after 1 h...				J Med Chem 55: 528-37 (2012) Article DOI: 10.1021/jm201436k BindingDB Entry DOI: 10.7270/Q2PN963M
University of Illinois Curated by ChEMBL					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM17292 ((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	0.123	n/a	n/a	n/a	n/a
University of Illinois Curated by ChEMBL					Assay Description Agonist activity at human ERalpha expressed in HEC-1 cells coexpressing beta-gal assessed as luciferase activity after 24 hrs by reporter gene assay				J Med Chem 55: 528-37 (2012) Article DOI: 10.1021/jm201436k BindingDB Entry DOI: 10.7270/Q2PN963M
University of Illinois Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Estrogen receptor beta (Homo sapiens (Human))	BDBM50364075 (CHEMBL1950809) Show SMILES Oc1ccc(C[C@H](C#N)c2ccc(O)cc2)cc1 \|r\| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	32.3	n/a	n/a	n/a	n/a
University of Illinois Curated by ChEMBL					Assay Description Agonist activity at human N-His6-tagged terbium-labelled ERbeta ligand binding domain expressed in Escherichia coli BL21 cells assessed as recruitmen...				J Med Chem 55: 528-37 (2012) Article DOI: 10.1021/jm201436k BindingDB Entry DOI: 10.7270/Q2PN963M
University of Illinois Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Estrogen receptor (Homo sapiens (Human))	BDBM50364075 (CHEMBL1950809) Show SMILES Oc1ccc(C[C@H](C#N)c2ccc(O)cc2)cc1 \|r\| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	6.20	n/a	n/a	n/a	n/a
University of Illinois Curated by ChEMBL					Assay Description Agonist activity at human N-His6-tagged terbium-labelled NRID-SRC3 of ERalpha ligand binding domain expressed in Escherichia coli BL21 cells after 1 ...				J Med Chem 55: 528-37 (2012) Article DOI: 10.1021/jm201436k BindingDB Entry DOI: 10.7270/Q2PN963M
University of Illinois Curated by ChEMBL					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM50106635 ((+/-)-2,3-bis(4-hydroxyphenyl)propanenitrile \| 2,3...) Show SMILES Oc1ccc(CC(C#N)c2ccc(O)cc2)cc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	208	n/a	n/a	n/a	n/a
University of Illinois Curated by ChEMBL					Assay Description Agonist activity at human ERalpha expressed in U2OS cells coexpressing pCMX-hSRC3 assessed as luciferase activity after 24 hrs by reporter gene assay				J Med Chem 55: 528-37 (2012) Article DOI: 10.1021/jm201436k BindingDB Entry DOI: 10.7270/Q2PN963M
University of Illinois Curated by ChEMBL					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM50364075 (CHEMBL1950809) Show SMILES Oc1ccc(C[C@H](C#N)c2ccc(O)cc2)cc1 \|r\| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	317	n/a	n/a	n/a	n/a
University of Illinois Curated by ChEMBL					Assay Description Agonist activity at human ERalpha expressed in HEC-1 cells coexpressing beta-gal assessed as luciferase activity after 24 hrs by reporter gene assay				J Med Chem 55: 528-37 (2012) Article DOI: 10.1021/jm201436k BindingDB Entry DOI: 10.7270/Q2PN963M
University of Illinois Curated by ChEMBL					More data for this Ligand-Target Pair
Estrogen receptor beta (Homo sapiens (Human))	BDBM50106635 ((+/-)-2,3-bis(4-hydroxyphenyl)propanenitrile \| 2,3...) Show SMILES Oc1ccc(CC(C#N)c2ccc(O)cc2)cc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	16.7	n/a	n/a	n/a	n/a
University of Illinois Curated by ChEMBL					Assay Description Agonist activity at human N-His6-tagged terbium-labelled ERbeta ligand binding domain expressed in Escherichia coli BL21 cells assessed as recruitmen...				J Med Chem 55: 528-37 (2012) Article DOI: 10.1021/jm201436k BindingDB Entry DOI: 10.7270/Q2PN963M
University of Illinois Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Estrogen receptor beta (Homo sapiens (Human))	BDBM50364076 (CHEMBL198159) Show SMILES Oc1ccc(C[C@@H](C#N)c2ccc(O)cc2)cc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3.40	n/a	n/a	n/a	n/a
University of Illinois Curated by ChEMBL					Assay Description Agonist activity at human ERbeta expressed in U2OS cells coexpressing pCMX-hSRC3 assessed as luciferase activity after 24 hrs by reporter gene assay				J Med Chem 55: 528-37 (2012) Article DOI: 10.1021/jm201436k BindingDB Entry DOI: 10.7270/Q2PN963M
University of Illinois Curated by ChEMBL					More data for this Ligand-Target Pair
Estrogen receptor beta (Homo sapiens (Human))	BDBM50106635 ((+/-)-2,3-bis(4-hydroxyphenyl)propanenitrile \| 2,3...) Show SMILES Oc1ccc(CC(C#N)c2ccc(O)cc2)cc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	3.70	n/a	n/a	n/a	n/a
University of Illinois Curated by ChEMBL					Assay Description Agonist activity at human ERbeta expressed in U2OS cells coexpressing pCMX-hSRC3 assessed as luciferase activity after 24 hrs by reporter gene assay				J Med Chem 55: 528-37 (2012) Article DOI: 10.1021/jm201436k BindingDB Entry DOI: 10.7270/Q2PN963M
University of Illinois Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Estrogen receptor (Homo sapiens (Human))	BDBM50106635 ((+/-)-2,3-bis(4-hydroxyphenyl)propanenitrile \| 2,3...) Show SMILES Oc1ccc(CC(C#N)c2ccc(O)cc2)cc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	876	n/a	n/a	n/a	n/a
University of Illinois Curated by ChEMBL					Assay Description Agonist activity at human N-His6-tagged terbium-labelled ERalpha ligand binding domain expressed in Escherichia coli BL21 cells assessed as recruitme...				J Med Chem 55: 528-37 (2012) Article DOI: 10.1021/jm201436k BindingDB Entry DOI: 10.7270/Q2PN963M
University of Illinois Curated by ChEMBL					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM17292 ((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	3	n/a	n/a	n/a	n/a
University of Illinois Curated by ChEMBL					Assay Description Agonist activity at human N-His6-tagged terbium-labelled ERalpha ligand binding domain expressed in Escherichia coli BL21 cells assessed as recruitme...				J Med Chem 55: 528-37 (2012) Article DOI: 10.1021/jm201436k BindingDB Entry DOI: 10.7270/Q2PN963M
University of Illinois Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Estrogen receptor (Homo sapiens (Human))	BDBM17292 ((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	0.560	n/a	n/a	n/a	n/a
University of Illinois Curated by ChEMBL					Assay Description Agonist activity at human N-His6-tagged terbium-labelled NRID-SRC3 of ERalpha ligand binding domain expressed in Escherichia coli BL21 cells after 1 ...				J Med Chem 55: 528-37 (2012) Article DOI: 10.1021/jm201436k BindingDB Entry DOI: 10.7270/Q2PN963M
University of Illinois Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Estrogen receptor beta (Homo sapiens (Human))	BDBM50364075 (CHEMBL1950809) Show SMILES Oc1ccc(C[C@H](C#N)c2ccc(O)cc2)cc1 \|r\| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	3.80	n/a	n/a	n/a	n/a
University of Illinois Curated by ChEMBL					Assay Description Agonist activity at human ERbeta expressed in U2OS cells coexpressing pCMX-hSRC3 assessed as luciferase activity after 24 hrs by reporter gene assay				J Med Chem 55: 528-37 (2012) Article DOI: 10.1021/jm201436k BindingDB Entry DOI: 10.7270/Q2PN963M
University of Illinois Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Estrogen receptor beta (Homo sapiens (Human))	BDBM50364075 (CHEMBL1950809) Show SMILES Oc1ccc(C[C@H](C#N)c2ccc(O)cc2)cc1 \|r\| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	3	n/a	n/a	n/a	n/a
University of Illinois Curated by ChEMBL					Assay Description Agonist activity at human ERbeta expressed in HEC-1 cells coexpressing beta-gal assessed as luciferase activity after 24 hrs by reporter gene assay				J Med Chem 55: 528-37 (2012) Article DOI: 10.1021/jm201436k BindingDB Entry DOI: 10.7270/Q2PN963M
University of Illinois Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Estrogen receptor (Homo sapiens (Human))	BDBM50364075 (CHEMBL1950809) Show SMILES Oc1ccc(C[C@H](C#N)c2ccc(O)cc2)cc1 \|r\| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	212	n/a	n/a	n/a	n/a
University of Illinois Curated by ChEMBL					Assay Description Agonist activity at human ERalpha expressed in U2OS cells coexpressing pCMX-hSRC3 assessed as luciferase activity after 24 hrs by reporter gene assay				J Med Chem 55: 528-37 (2012) Article DOI: 10.1021/jm201436k BindingDB Entry DOI: 10.7270/Q2PN963M
University of Illinois Curated by ChEMBL					More data for this Ligand-Target Pair
Estrogen receptor beta (Homo sapiens (Human))	BDBM50364076 (CHEMBL198159) Show SMILES Oc1ccc(C[C@@H](C#N)c2ccc(O)cc2)cc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3.20	n/a	n/a	n/a	n/a
University of Illinois Curated by ChEMBL					Assay Description Agonist activity at human ERbeta expressed in HEC-1 cells coexpressing beta-gal assessed as luciferase activity after 24 hrs by reporter gene assay				J Med Chem 55: 528-37 (2012) Article DOI: 10.1021/jm201436k BindingDB Entry DOI: 10.7270/Q2PN963M
University of Illinois Curated by ChEMBL					More data for this Ligand-Target Pair
Estrogen receptor beta (Homo sapiens (Human))	BDBM17292 ((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	0.200	n/a	n/a	n/a	n/a
University of Illinois Curated by ChEMBL					Assay Description Agonist activity at human ERbeta expressed in HEC-1 cells coexpressing beta-gal assessed as luciferase activity after 24 hrs by reporter gene assay				J Med Chem 55: 528-37 (2012) Article DOI: 10.1021/jm201436k BindingDB Entry DOI: 10.7270/Q2PN963M
University of Illinois Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)

* indicates data uncertainty>20%