BindingDB logo
myBDB logout

PubMed code 22148323

Compile data set for download or QSAR
Found 53 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Acetyl-CoA carboxylase 2


(Homo sapiens (Human))		BDBM50365293
PNG
(CHEMBL1958374)
Show SMILES Cc1nc2c(C)cc(cc2[nH]1)C(=O)N1CCC2(CC1)CC(=O)c1nn(cc1O2)C(C)(C)C
Show InChI InChI=1S/C24H29N5O3/c1-14-10-16(11-17-20(14)26-15(2)25-17)22(31)28-8-6-24(7-9-28)12-18(30)21-19(32-24)13-29(27-21)23(3,4)5/h10-11,13H,6-9,12H2,1-5H3,(H,25,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 6.60n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human Acetyl-CoA carboxylase 2 expressed in CHO cells after 1 hr by fluorescence assay

J Med Chem 55: 935-42 (2012)


Article DOI: 10.1021/jm201503u
BindingDB Entry DOI: 10.7270/Q2CZ37MS
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2


(Homo sapiens (Human))		BDBM50365279
PNG
(CHEMBL1958360)
Show SMILES Cc1cc(cc2cn[nH]c12)C(=O)N1CCC2(CC1)CC(=O)c1nn(cc1O2)C(C)(C)C
Show InChI InChI=1S/C23H27N5O3/c1-14-9-15(10-16-12-24-25-19(14)16)21(30)27-7-5-23(6-8-27)11-17(29)20-18(31-23)13-28(26-20)22(2,3)4/h9-10,12-13H,5-8,11H2,1-4H3,(H,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 6.90n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human Acetyl-CoA carboxylase 2 expressed in CHO cells after 1 hr by fluorescence assay

J Med Chem 55: 935-42 (2012)


Article DOI: 10.1021/jm201503u
BindingDB Entry DOI: 10.7270/Q2CZ37MS
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1


(Rattus norvegicus (Rat))		BDBM50365279
PNG
(CHEMBL1958360)
Show SMILES Cc1cc(cc2cn[nH]c12)C(=O)N1CCC2(CC1)CC(=O)c1nn(cc1O2)C(C)(C)C
Show InChI InChI=1S/C23H27N5O3/c1-14-9-15(10-16-12-24-25-19(14)16)21(30)27-7-5-23(6-8-27)11-17(29)20-18(31-23)13-28(26-20)22(2,3)4/h9-10,12-13H,5-8,11H2,1-4H3,(H,24,25)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 7n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...

J Med Chem 55: 935-42 (2012)


Article DOI: 10.1021/jm201503u
BindingDB Entry DOI: 10.7270/Q2CZ37MS
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2


(Homo sapiens (Human))		BDBM50365292
PNG
(CHEMBL1958373)
Show SMILES Cc1cc(cc2[nH]cnc12)C(=O)N1CCC2(CC1)CC(=O)c1nn(cc1O2)C(C)(C)C
Show InChI InChI=1S/C23H27N5O3/c1-14-9-15(10-16-19(14)25-13-24-16)21(30)27-7-5-23(6-8-27)11-17(29)20-18(31-23)12-28(26-20)22(2,3)4/h9-10,12-13H,5-8,11H2,1-4H3,(H,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 7.40n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human Acetyl-CoA carboxylase 2 expressed in CHO cells after 1 hr by fluorescence assay

J Med Chem 55: 935-42 (2012)


Article DOI: 10.1021/jm201503u
BindingDB Entry DOI: 10.7270/Q2CZ37MS
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1


(Rattus norvegicus (Rat))		BDBM50365287
PNG
(CHEMBL1958368)
Show SMILES CCn1nc2c(OC3(CCN(CC3)C(=O)c3cc(C)c4[nH]cc(C)c4c3)CC2=O)c1C
Show InChI InChI=1S/C24H28N4O3/c1-5-28-16(4)22-21(26-28)19(29)12-24(31-22)6-8-27(9-7-24)23(30)17-10-14(2)20-18(11-17)15(3)13-25-20/h10-11,13,25H,5-9,12H2,1-4H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 9.10n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...

J Med Chem 55: 935-42 (2012)


Article DOI: 10.1021/jm201503u
BindingDB Entry DOI: 10.7270/Q2CZ37MS
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2


(Homo sapiens (Human))		BDBM50365277
PNG
(CHEMBL1958359)
Show SMILES Cc1cc(cc2cn[nH]c12)C(=O)N1CCC2(CC1)CC(=O)c1nn(cc1O2)C1CCCC1
Show InChI InChI=1S/C24H27N5O3/c1-15-10-16(11-17-13-25-26-21(15)17)23(31)28-8-6-24(7-9-28)12-19(30)22-20(32-24)14-29(27-22)18-4-2-3-5-18/h10-11,13-14,18H,2-9,12H2,1H3,(H,25,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 9.40n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human Acetyl-CoA carboxylase 2 expressed in CHO cells after 1 hr by fluorescence assay

J Med Chem 55: 935-42 (2012)


Article DOI: 10.1021/jm201503u
BindingDB Entry DOI: 10.7270/Q2CZ37MS
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1


(Rattus norvegicus (Rat))		BDBM50365292
PNG
(CHEMBL1958373)
Show SMILES Cc1cc(cc2[nH]cnc12)C(=O)N1CCC2(CC1)CC(=O)c1nn(cc1O2)C(C)(C)C
Show InChI InChI=1S/C23H27N5O3/c1-14-9-15(10-16-19(14)25-13-24-16)21(30)27-7-5-23(6-8-27)11-17(29)20-18(31-23)12-28(26-20)22(2,3)4/h9-10,12-13H,5-8,11H2,1-4H3,(H,24,25)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 9.60n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...

J Med Chem 55: 935-42 (2012)


Article DOI: 10.1021/jm201503u
BindingDB Entry DOI: 10.7270/Q2CZ37MS
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1


(Rattus norvegicus (Rat))		BDBM50365293
PNG
(CHEMBL1958374)
Show SMILES Cc1nc2c(C)cc(cc2[nH]1)C(=O)N1CCC2(CC1)CC(=O)c1nn(cc1O2)C(C)(C)C
Show InChI InChI=1S/C24H29N5O3/c1-14-10-16(11-17-20(14)26-15(2)25-17)22(31)28-8-6-24(7-9-28)12-18(30)21-19(32-24)13-29(27-21)23(3,4)5/h10-11,13H,6-9,12H2,1-5H3,(H,25,26)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 10n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...

J Med Chem 55: 935-42 (2012)


Article DOI: 10.1021/jm201503u
BindingDB Entry DOI: 10.7270/Q2CZ37MS
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2


(Homo sapiens (Human))		BDBM50365295
PNG
(CHEMBL1955896)
Show SMILES CC(C)(C)n1cc2OC3(CCN(CC3)C(=O)c3ccc4nc[nH]c4c3)CC(=O)c2n1
Show InChI InChI=1S/C22H25N5O3/c1-21(2,3)27-12-18-19(25-27)17(28)11-22(30-18)6-8-26(9-7-22)20(29)14-4-5-15-16(10-14)24-13-23-15/h4-5,10,12-13H,6-9,11H2,1-3H3,(H,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 11n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human Acetyl-CoA carboxylase 2 expressed in CHO cells after 1 hr by fluorescence assay

J Med Chem 55: 935-42 (2012)


Article DOI: 10.1021/jm201503u
BindingDB Entry DOI: 10.7270/Q2CZ37MS
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1


(Rattus norvegicus (Rat))		BDBM50365284
PNG
(CHEMBL1958365)
Show SMILES CCOc1cc(cc2c(C)n[nH]c12)C(=O)N1CCC2(CC1)CC(=O)c1nn(CC)c(C)c1O2
Show InChI InChI=1S/C24H29N5O4/c1-5-29-15(4)22-21(27-29)18(30)13-24(33-22)7-9-28(10-8-24)23(31)16-11-17-14(3)25-26-20(17)19(12-16)32-6-2/h11-12H,5-10,13H2,1-4H3,(H,25,26)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 11.5n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...

J Med Chem 55: 935-42 (2012)


Article DOI: 10.1021/jm201503u
BindingDB Entry DOI: 10.7270/Q2CZ37MS
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1


(Rattus norvegicus (Rat))		BDBM50365290
PNG
(CHEMBL1958371)
Show SMILES CC(C)n1cc2OC3(CCN(CC3)C(=O)c3cc(C)c4[nH]nc(C)c4c3)CC(=O)c2n1
Show InChI InChI=1S/C23H27N5O3/c1-13(2)28-12-19-21(26-28)18(29)11-23(31-19)5-7-27(8-6-23)22(30)16-9-14(3)20-17(10-16)15(4)24-25-20/h9-10,12-13H,5-8,11H2,1-4H3,(H,24,25)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 12n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...

J Med Chem 55: 935-42 (2012)


Article DOI: 10.1021/jm201503u
BindingDB Entry DOI: 10.7270/Q2CZ37MS
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1


(Rattus norvegicus (Rat))		BDBM50365281
PNG
(CHEMBL1958362)
Show SMILES CCn1nc2c(OC3(CCN(CC3)C(=O)c3cc(C)c4[nH]nc(C)c4c3)CC2=O)c1C
Show InChI InChI=1S/C23H27N5O3/c1-5-28-15(4)21-20(26-28)18(29)12-23(31-21)6-8-27(9-7-23)22(30)16-10-13(2)19-17(11-16)14(3)24-25-19/h10-11H,5-9,12H2,1-4H3,(H,24,25)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 12n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...

J Med Chem 55: 935-42 (2012)


Article DOI: 10.1021/jm201503u
BindingDB Entry DOI: 10.7270/Q2CZ37MS
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1


(Rattus norvegicus (Rat))		BDBM50365294
PNG
(CHEMBL1955895)
Show SMILES Cn1ncc2ccc(cc12)C(=O)N1CCC2(CC1)CC(=O)c1nn(cc1O2)C(C)(C)C
Show InChI InChI=1S/C23H27N5O3/c1-22(2,3)28-14-19-20(25-28)18(29)12-23(31-19)7-9-27(10-8-23)21(30)15-5-6-16-13-24-26(4)17(16)11-15/h5-6,11,13-14H,7-10,12H2,1-4H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 13n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...

J Med Chem 55: 935-42 (2012)


Article DOI: 10.1021/jm201503u
BindingDB Entry DOI: 10.7270/Q2CZ37MS
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2


(Homo sapiens (Human))		BDBM50365281
PNG
(CHEMBL1958362)
Show SMILES CCn1nc2c(OC3(CCN(CC3)C(=O)c3cc(C)c4[nH]nc(C)c4c3)CC2=O)c1C
Show InChI InChI=1S/C23H27N5O3/c1-5-28-15(4)21-20(26-28)18(29)12-23(31-21)6-8-27(9-7-23)22(30)16-10-13(2)19-17(11-16)14(3)24-25-19/h10-11H,5-9,12H2,1-4H3,(H,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 13n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human Acetyl-CoA carboxylase 2 expressed in CHO cells after 1 hr by fluorescence assay

J Med Chem 55: 935-42 (2012)


Article DOI: 10.1021/jm201503u
BindingDB Entry DOI: 10.7270/Q2CZ37MS
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1


(Rattus norvegicus (Rat))		BDBM50365285
PNG
(CHEMBL1958366)
Show SMILES CCOc1cc(cc2c(CC)n[nH]c12)C(=O)N1CCC2(CC1)CC(=O)c1nn(CC)c(C)c1O2
Show InChI InChI=1S/C25H31N5O4/c1-5-18-17-12-16(13-20(33-7-3)21(17)27-26-18)24(32)29-10-8-25(9-11-29)14-19(31)22-23(34-25)15(4)30(6-2)28-22/h12-13H,5-11,14H2,1-4H3,(H,26,27)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 13n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...

J Med Chem 55: 935-42 (2012)


Article DOI: 10.1021/jm201503u
BindingDB Entry DOI: 10.7270/Q2CZ37MS
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2


(Homo sapiens (Human))		BDBM50365290
PNG
(CHEMBL1958371)
Show SMILES CC(C)n1cc2OC3(CCN(CC3)C(=O)c3cc(C)c4[nH]nc(C)c4c3)CC(=O)c2n1
Show InChI InChI=1S/C23H27N5O3/c1-13(2)28-12-19-21(26-28)18(29)11-23(31-19)5-7-27(8-6-23)22(30)16-9-14(3)20-17(10-16)15(4)24-25-20/h9-10,12-13H,5-8,11H2,1-4H3,(H,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 14n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human Acetyl-CoA carboxylase 2 expressed in CHO cells after 1 hr by fluorescence assay

J Med Chem 55: 935-42 (2012)


Article DOI: 10.1021/jm201503u
BindingDB Entry DOI: 10.7270/Q2CZ37MS
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1


(Rattus norvegicus (Rat))		BDBM50365277
PNG
(CHEMBL1958359)
Show SMILES Cc1cc(cc2cn[nH]c12)C(=O)N1CCC2(CC1)CC(=O)c1nn(cc1O2)C1CCCC1
Show InChI InChI=1S/C24H27N5O3/c1-15-10-16(11-17-13-25-26-21(15)17)23(31)28-8-6-24(7-9-28)12-19(30)22-20(32-24)14-29(27-22)18-4-2-3-5-18/h10-11,13-14,18H,2-9,12H2,1H3,(H,25,26)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 14n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...

J Med Chem 55: 935-42 (2012)


Article DOI: 10.1021/jm201503u
BindingDB Entry DOI: 10.7270/Q2CZ37MS
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2


(Homo sapiens (Human))		BDBM50365276
PNG
(CHEMBL1958358)
Show SMILES Cc1cc(cc2cn[nH]c12)C(=O)N1CCC2(CC1)CC(=O)c1nn(cc1O2)C1CCC1
Show InChI InChI=1S/C23H25N5O3/c1-14-9-15(10-16-12-24-25-20(14)16)22(30)27-7-5-23(6-8-27)11-18(29)21-19(31-23)13-28(26-21)17-3-2-4-17/h9-10,12-13,17H,2-8,11H2,1H3,(H,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 14n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human Acetyl-CoA carboxylase 2 expressed in CHO cells after 1 hr by fluorescence assay

J Med Chem 55: 935-42 (2012)


Article DOI: 10.1021/jm201503u
BindingDB Entry DOI: 10.7270/Q2CZ37MS
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1


(Rattus norvegicus (Rat))		BDBM50365276
PNG
(CHEMBL1958358)
Show SMILES Cc1cc(cc2cn[nH]c12)C(=O)N1CCC2(CC1)CC(=O)c1nn(cc1O2)C1CCC1
Show InChI InChI=1S/C23H25N5O3/c1-14-9-15(10-16-12-24-25-20(14)16)22(30)27-7-5-23(6-8-27)11-18(29)21-19(31-23)13-28(26-21)17-3-2-4-17/h9-10,12-13,17H,2-8,11H2,1H3,(H,24,25)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 15n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...

J Med Chem 55: 935-42 (2012)


Article DOI: 10.1021/jm201503u
BindingDB Entry DOI: 10.7270/Q2CZ37MS
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1


(Rattus norvegicus (Rat))		BDBM50365295
PNG
(CHEMBL1955896)
Show SMILES CC(C)(C)n1cc2OC3(CCN(CC3)C(=O)c3ccc4nc[nH]c4c3)CC(=O)c2n1
Show InChI InChI=1S/C22H25N5O3/c1-21(2,3)27-12-18-19(25-27)17(28)11-22(30-18)6-8-26(9-7-22)20(29)14-4-5-15-16(10-14)24-13-23-15/h4-5,10,12-13H,6-9,11H2,1-3H3,(H,23,24)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 17n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...

J Med Chem 55: 935-42 (2012)


Article DOI: 10.1021/jm201503u
BindingDB Entry DOI: 10.7270/Q2CZ37MS
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2


(Homo sapiens (Human))		BDBM50365285
PNG
(CHEMBL1958366)
Show SMILES CCOc1cc(cc2c(CC)n[nH]c12)C(=O)N1CCC2(CC1)CC(=O)c1nn(CC)c(C)c1O2
Show InChI InChI=1S/C25H31N5O4/c1-5-18-17-12-16(13-20(33-7-3)21(17)27-26-18)24(32)29-10-8-25(9-11-29)14-19(31)22-23(34-25)15(4)30(6-2)28-22/h12-13H,5-11,14H2,1-4H3,(H,26,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 18n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human Acetyl-CoA carboxylase 2 expressed in CHO cells after 1 hr by fluorescence assay

J Med Chem 55: 935-42 (2012)


Article DOI: 10.1021/jm201503u
BindingDB Entry DOI: 10.7270/Q2CZ37MS
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2


(Homo sapiens (Human))		BDBM50365291
PNG
(CHEMBL1958372)
Show SMILES Cc1n[nH]c2c(C)cc(cc12)C(=O)N1CCC2(CC1)CC(=O)c1nn(C3CCOC3)c(C)c1O2
Show InChI InChI=1S/C25H29N5O4/c1-14-10-17(11-19-15(2)26-27-21(14)19)24(32)29-7-5-25(6-8-29)12-20(31)22-23(34-25)16(3)30(28-22)18-4-9-33-13-18/h10-11,18H,4-9,12-13H2,1-3H3,(H,26,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 20n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human Acetyl-CoA carboxylase 2 expressed in CHO cells after 1 hr by fluorescence assay

J Med Chem 55: 935-42 (2012)


Article DOI: 10.1021/jm201503u
BindingDB Entry DOI: 10.7270/Q2CZ37MS
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1


(Rattus norvegicus (Rat))		BDBM50365291
PNG
(CHEMBL1958372)
Show SMILES Cc1n[nH]c2c(C)cc(cc12)C(=O)N1CCC2(CC1)CC(=O)c1nn(C3CCOC3)c(C)c1O2
Show InChI InChI=1S/C25H29N5O4/c1-14-10-17(11-19-15(2)26-27-21(14)19)24(32)29-7-5-25(6-8-29)12-20(31)22-23(34-25)16(3)30(28-22)18-4-9-33-13-18/h10-11,18H,4-9,12-13H2,1-3H3,(H,26,27)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 21n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...

J Med Chem 55: 935-42 (2012)


Article DOI: 10.1021/jm201503u
BindingDB Entry DOI: 10.7270/Q2CZ37MS
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2


(Homo sapiens (Human))		BDBM50365294
PNG
(CHEMBL1955895)
Show SMILES Cn1ncc2ccc(cc12)C(=O)N1CCC2(CC1)CC(=O)c1nn(cc1O2)C(C)(C)C
Show InChI InChI=1S/C23H27N5O3/c1-22(2,3)28-14-19-20(25-28)18(29)12-23(31-19)7-9-27(10-8-23)21(30)15-5-6-16-13-24-26(4)17(16)11-15/h5-6,11,13-14H,7-10,12H2,1-4H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 21n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human Acetyl-CoA carboxylase 2 expressed in CHO cells after 1 hr by fluorescence assay

J Med Chem 55: 935-42 (2012)


Article DOI: 10.1021/jm201503u
BindingDB Entry DOI: 10.7270/Q2CZ37MS
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1


(Rattus norvegicus (Rat))		BDBM50365274
PNG
(CHEMBL1958356)
Show SMILES CC(C)n1cc2OC3(CCN(CC3)C(=O)c3cc(C)c4[nH]ncc4c3)CC(=O)c2n1
Show InChI InChI=1S/C22H25N5O3/c1-13(2)27-12-18-20(25-27)17(28)10-22(30-18)4-6-26(7-5-22)21(29)15-8-14(3)19-16(9-15)11-23-24-19/h8-9,11-13H,4-7,10H2,1-3H3,(H,23,24)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 22n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...

J Med Chem 55: 935-42 (2012)


Article DOI: 10.1021/jm201503u
BindingDB Entry DOI: 10.7270/Q2CZ37MS
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2


(Homo sapiens (Human))		BDBM50365274
PNG
(CHEMBL1958356)
Show SMILES CC(C)n1cc2OC3(CCN(CC3)C(=O)c3cc(C)c4[nH]ncc4c3)CC(=O)c2n1
Show InChI InChI=1S/C22H25N5O3/c1-13(2)27-12-18-20(25-27)17(28)10-22(30-18)4-6-26(7-5-22)21(29)15-8-14(3)19-16(9-15)11-23-24-19/h8-9,11-13H,4-7,10H2,1-3H3,(H,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 23n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human Acetyl-CoA carboxylase 2 expressed in CHO cells after 1 hr by fluorescence assay

J Med Chem 55: 935-42 (2012)


Article DOI: 10.1021/jm201503u
BindingDB Entry DOI: 10.7270/Q2CZ37MS
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2


(Homo sapiens (Human))		BDBM50365284
PNG
(CHEMBL1958365)
Show SMILES CCOc1cc(cc2c(C)n[nH]c12)C(=O)N1CCC2(CC1)CC(=O)c1nn(CC)c(C)c1O2
Show InChI InChI=1S/C24H29N5O4/c1-5-29-15(4)22-21(27-29)18(30)13-24(33-22)7-9-28(10-8-24)23(31)16-11-17-14(3)25-26-20(17)19(12-16)32-6-2/h11-12H,5-10,13H2,1-4H3,(H,25,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 27n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human Acetyl-CoA carboxylase 2 expressed in CHO cells after 1 hr by fluorescence assay

J Med Chem 55: 935-42 (2012)


Article DOI: 10.1021/jm201503u
BindingDB Entry DOI: 10.7270/Q2CZ37MS
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1


(Rattus norvegicus (Rat))		BDBM50365272
PNG
(CHEMBL1958354)
Show SMILES CCn1nc2c(OC3(CCN(CC3)C(=O)c3cc(C)c4[nH]ncc4c3)CC2=O)c1C
Show InChI InChI=1S/C22H25N5O3/c1-4-27-14(3)20-19(25-27)17(28)11-22(30-20)5-7-26(8-6-22)21(29)15-9-13(2)18-16(10-15)12-23-24-18/h9-10,12H,4-8,11H2,1-3H3,(H,23,24)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 28n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...

J Med Chem 55: 935-42 (2012)


Article DOI: 10.1021/jm201503u
BindingDB Entry DOI: 10.7270/Q2CZ37MS
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2


(Homo sapiens (Human))		BDBM50365287
PNG
(CHEMBL1958368)
Show SMILES CCn1nc2c(OC3(CCN(CC3)C(=O)c3cc(C)c4[nH]cc(C)c4c3)CC2=O)c1C
Show InChI InChI=1S/C24H28N4O3/c1-5-28-16(4)22-21(26-28)19(29)12-24(31-22)6-8-27(9-7-24)23(30)17-10-14(2)20-18(11-17)15(3)13-25-20/h10-11,13,25H,5-9,12H2,1-4H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 29n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human Acetyl-CoA carboxylase 2 expressed in CHO cells after 1 hr by fluorescence assay

J Med Chem 55: 935-42 (2012)


Article DOI: 10.1021/jm201503u
BindingDB Entry DOI: 10.7270/Q2CZ37MS
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1


(Rattus norvegicus (Rat))		BDBM50365280
PNG
(CHEMBL1958361)
Show SMILES CCn1nc2c(OC3(CCN(CC3)C(=O)c3ccc4[nH]nc(C)c4c3)CC2=O)c1C
Show InChI InChI=1S/C22H25N5O3/c1-4-27-14(3)20-19(25-27)18(28)12-22(30-20)7-9-26(10-8-22)21(29)15-5-6-17-16(11-15)13(2)23-24-17/h5-6,11H,4,7-10,12H2,1-3H3,(H,23,24)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 29n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...

J Med Chem 55: 935-42 (2012)


Article DOI: 10.1021/jm201503u
BindingDB Entry DOI: 10.7270/Q2CZ37MS
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1


(Rattus norvegicus (Rat))		BDBM50365283
PNG
(CHEMBL1958364)
Show SMILES CCc1cc(cc2cn[nH]c12)C(=O)N1CCC2(CC1)CC(=O)c1nn(CC)c(C)c1O2
Show InChI InChI=1S/C23H27N5O3/c1-4-15-10-16(11-17-13-24-25-19(15)17)22(30)27-8-6-23(7-9-27)12-18(29)20-21(31-23)14(3)28(5-2)26-20/h10-11,13H,4-9,12H2,1-3H3,(H,24,25)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 31n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...

J Med Chem 55: 935-42 (2012)


Article DOI: 10.1021/jm201503u
BindingDB Entry DOI: 10.7270/Q2CZ37MS
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1


(Rattus norvegicus (Rat))		BDBM50365289
PNG
(CHEMBL1958370)
Show SMILES CCn1nc2c(OC3(CCN(CC3)C(=O)c3cc(C)c4nc(C)[nH]c4c3)CC2=O)c1C
Show InChI InChI=1S/C23H27N5O3/c1-5-28-14(3)21-20(26-28)18(29)12-23(31-21)6-8-27(9-7-23)22(30)16-10-13(2)19-17(11-16)24-15(4)25-19/h10-11H,5-9,12H2,1-4H3,(H,24,25)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 34n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...

J Med Chem 55: 935-42 (2012)


Article DOI: 10.1021/jm201503u
BindingDB Entry DOI: 10.7270/Q2CZ37MS
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1


(Rattus norvegicus (Rat))		BDBM50365282
PNG
(CHEMBL1958363)
Show SMILES CCc1n[nH]c2ccc(cc12)C(=O)N1CCC2(CC1)CC(=O)c1nn(CC)c(C)c1O2
Show InChI InChI=1S/C23H27N5O3/c1-4-17-16-12-15(6-7-18(16)25-24-17)22(30)27-10-8-23(9-11-27)13-19(29)20-21(31-23)14(3)28(5-2)26-20/h6-7,12H,4-5,8-11,13H2,1-3H3,(H,24,25)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 36n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...

J Med Chem 55: 935-42 (2012)


Article DOI: 10.1021/jm201503u
BindingDB Entry DOI: 10.7270/Q2CZ37MS
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2


(Homo sapiens (Human))		BDBM50365272
PNG
(CHEMBL1958354)
Show SMILES CCn1nc2c(OC3(CCN(CC3)C(=O)c3cc(C)c4[nH]ncc4c3)CC2=O)c1C
Show InChI InChI=1S/C22H25N5O3/c1-4-27-14(3)20-19(25-27)17(28)11-22(30-20)5-7-26(8-6-22)21(29)15-9-13(2)18-16(10-15)12-23-24-18/h9-10,12H,4-8,11H2,1-3H3,(H,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 37n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human Acetyl-CoA carboxylase 2 expressed in CHO cells after 1 hr by fluorescence assay

J Med Chem 55: 935-42 (2012)


Article DOI: 10.1021/jm201503u
BindingDB Entry DOI: 10.7270/Q2CZ37MS
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2


(Homo sapiens (Human))		BDBM50365283
PNG
(CHEMBL1958364)
Show SMILES CCc1cc(cc2cn[nH]c12)C(=O)N1CCC2(CC1)CC(=O)c1nn(CC)c(C)c1O2
Show InChI InChI=1S/C23H27N5O3/c1-4-15-10-16(11-17-13-24-25-19(15)17)22(30)27-8-6-23(7-9-27)12-18(29)20-21(31-23)14(3)28(5-2)26-20/h10-11,13H,4-9,12H2,1-3H3,(H,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 37n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human Acetyl-CoA carboxylase 2 expressed in CHO cells after 1 hr by fluorescence assay

J Med Chem 55: 935-42 (2012)


Article DOI: 10.1021/jm201503u
BindingDB Entry DOI: 10.7270/Q2CZ37MS
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2


(Homo sapiens (Human))		BDBM50365280
PNG
(CHEMBL1958361)
Show SMILES CCn1nc2c(OC3(CCN(CC3)C(=O)c3ccc4[nH]nc(C)c4c3)CC2=O)c1C
Show InChI InChI=1S/C22H25N5O3/c1-4-27-14(3)20-19(25-27)18(28)12-22(30-20)7-9-26(10-8-22)21(29)15-5-6-17-16(11-15)13(2)23-24-17/h5-6,11H,4,7-10,12H2,1-3H3,(H,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 42n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human Acetyl-CoA carboxylase 2 expressed in CHO cells after 1 hr by fluorescence assay

J Med Chem 55: 935-42 (2012)


Article DOI: 10.1021/jm201503u
BindingDB Entry DOI: 10.7270/Q2CZ37MS
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2


(Homo sapiens (Human))		BDBM50365273
PNG
(CHEMBL1958355)
Show SMILES CCCn1cc2OC3(CCN(CC3)C(=O)c3cc(C)c4[nH]ncc4c3)CC(=O)c2n1
Show InChI InChI=1S/C22H25N5O3/c1-3-6-27-13-18-20(25-27)17(28)11-22(30-18)4-7-26(8-5-22)21(29)15-9-14(2)19-16(10-15)12-23-24-19/h9-10,12-13H,3-8,11H2,1-2H3,(H,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 45n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human Acetyl-CoA carboxylase 2 expressed in CHO cells after 1 hr by fluorescence assay

J Med Chem 55: 935-42 (2012)


Article DOI: 10.1021/jm201503u
BindingDB Entry DOI: 10.7270/Q2CZ37MS
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1


(Rattus norvegicus (Rat))		BDBM50365278
PNG
(CHEMBL1955891)
Show SMILES Cc1cc(cc2cn[nH]c12)C(=O)N1CCC2(CC1)CC(=O)c1nn(cc1O2)C1CCCCC1
Show InChI InChI=1S/C25H29N5O3/c1-16-11-17(12-18-14-26-27-22(16)18)24(32)29-9-7-25(8-10-29)13-20(31)23-21(33-25)15-30(28-23)19-5-3-2-4-6-19/h11-12,14-15,19H,2-10,13H2,1H3,(H,26,27)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 46n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...

J Med Chem 55: 935-42 (2012)


Article DOI: 10.1021/jm201503u
BindingDB Entry DOI: 10.7270/Q2CZ37MS
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2


(Homo sapiens (Human))		BDBM50314924
PNG
(6,7-dimethyl-1'-(7-methyl-1H-indazole-5-carbonyl)s...)
Show SMILES Cc1cc2OC3(CCN(CC3)C(=O)c3cc(C)c4[nH]ncc4c3)CC(=O)c2cc1C
Show InChI InChI=1S/C24H25N3O3/c1-14-9-19-20(28)12-24(30-21(19)10-15(14)2)4-6-27(7-5-24)23(29)17-8-16(3)22-18(11-17)13-25-26-22/h8-11,13H,4-7,12H2,1-3H3,(H,25,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
PDB
UniChem

Similars
Article
PubMed
n/an/a 48n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human Acetyl-CoA carboxylase 2 expressed in CHO cells after 1 hr by fluorescence assay

J Med Chem 55: 935-42 (2012)


Article DOI: 10.1021/jm201503u
BindingDB Entry DOI: 10.7270/Q2CZ37MS
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1


(Rattus norvegicus (Rat))		BDBM50365273
PNG
(CHEMBL1958355)
Show SMILES CCCn1cc2OC3(CCN(CC3)C(=O)c3cc(C)c4[nH]ncc4c3)CC(=O)c2n1
Show InChI InChI=1S/C22H25N5O3/c1-3-6-27-13-18-20(25-27)17(28)11-22(30-18)4-7-26(8-5-22)21(29)15-9-14(2)19-16(10-15)12-23-24-19/h9-10,12-13H,3-8,11H2,1-2H3,(H,23,24)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 48n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...

J Med Chem 55: 935-42 (2012)


Article DOI: 10.1021/jm201503u
BindingDB Entry DOI: 10.7270/Q2CZ37MS
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1


(Rattus norvegicus (Rat))		BDBM50365288
PNG
(CHEMBL1958369)
Show SMILES CCn1nc2c(OC3(CCN(CC3)C(=O)c3cc(C)c4nc[nH]c4c3)CC2=O)c1C
Show InChI InChI=1S/C22H25N5O3/c1-4-27-14(3)20-19(25-27)17(28)11-22(30-20)5-7-26(8-6-22)21(29)15-9-13(2)18-16(10-15)23-12-24-18/h9-10,12H,4-8,11H2,1-3H3,(H,23,24)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 49n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...

J Med Chem 55: 935-42 (2012)


Article DOI: 10.1021/jm201503u
BindingDB Entry DOI: 10.7270/Q2CZ37MS
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2


(Homo sapiens (Human))		BDBM50365289
PNG
(CHEMBL1958370)
Show SMILES CCn1nc2c(OC3(CCN(CC3)C(=O)c3cc(C)c4nc(C)[nH]c4c3)CC2=O)c1C
Show InChI InChI=1S/C23H27N5O3/c1-5-28-14(3)21-20(26-28)18(29)12-23(31-21)6-8-27(9-7-23)22(30)16-10-13(2)19-17(11-16)24-15(4)25-19/h10-11H,5-9,12H2,1-4H3,(H,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 56n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human Acetyl-CoA carboxylase 2 expressed in CHO cells after 1 hr by fluorescence assay

J Med Chem 55: 935-42 (2012)


Article DOI: 10.1021/jm201503u
BindingDB Entry DOI: 10.7270/Q2CZ37MS
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1


(Rattus norvegicus (Rat))		BDBM50365271
PNG
(CHEMBL1958353)
Show SMILES CCn1cc2OC3(CCN(CC3)C(=O)c3cc(C)c4[nH]ncc4c3)CC(=O)c2n1
Show InChI InChI=1S/C21H23N5O3/c1-3-26-12-17-19(24-26)16(27)10-21(29-17)4-6-25(7-5-21)20(28)14-8-13(2)18-15(9-14)11-22-23-18/h8-9,11-12H,3-7,10H2,1-2H3,(H,22,23)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 62n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...

J Med Chem 55: 935-42 (2012)


Article DOI: 10.1021/jm201503u
BindingDB Entry DOI: 10.7270/Q2CZ37MS
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2


(Homo sapiens (Human))		BDBM50365271
PNG
(CHEMBL1958353)
Show SMILES CCn1cc2OC3(CCN(CC3)C(=O)c3cc(C)c4[nH]ncc4c3)CC(=O)c2n1
Show InChI InChI=1S/C21H23N5O3/c1-3-26-12-17-19(24-26)16(27)10-21(29-17)4-6-25(7-5-21)20(28)14-8-13(2)18-15(9-14)11-22-23-18/h8-9,11-12H,3-7,10H2,1-2H3,(H,22,23)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 63n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human Acetyl-CoA carboxylase 2 expressed in CHO cells after 1 hr by fluorescence assay

J Med Chem 55: 935-42 (2012)


Article DOI: 10.1021/jm201503u
BindingDB Entry DOI: 10.7270/Q2CZ37MS
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2


(Homo sapiens (Human))		BDBM50365278
PNG
(CHEMBL1955891)
Show SMILES Cc1cc(cc2cn[nH]c12)C(=O)N1CCC2(CC1)CC(=O)c1nn(cc1O2)C1CCCCC1
Show InChI InChI=1S/C25H29N5O3/c1-16-11-17(12-18-14-26-27-22(16)18)24(32)29-9-7-25(8-10-29)13-20(31)23-21(33-25)15-30(28-23)19-5-3-2-4-6-19/h11-12,14-15,19H,2-10,13H2,1H3,(H,26,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 63n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human Acetyl-CoA carboxylase 2 expressed in CHO cells after 1 hr by fluorescence assay

J Med Chem 55: 935-42 (2012)


Article DOI: 10.1021/jm201503u
BindingDB Entry DOI: 10.7270/Q2CZ37MS
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2


(Homo sapiens (Human))		BDBM50365288
PNG
(CHEMBL1958369)
Show SMILES CCn1nc2c(OC3(CCN(CC3)C(=O)c3cc(C)c4nc[nH]c4c3)CC2=O)c1C
Show InChI InChI=1S/C22H25N5O3/c1-4-27-14(3)20-19(25-27)17(28)11-22(30-20)5-7-26(8-6-22)21(29)15-9-13(2)18-16(10-15)23-12-24-18/h9-10,12H,4-8,11H2,1-3H3,(H,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 80n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human Acetyl-CoA carboxylase 2 expressed in CHO cells after 1 hr by fluorescence assay

J Med Chem 55: 935-42 (2012)


Article DOI: 10.1021/jm201503u
BindingDB Entry DOI: 10.7270/Q2CZ37MS
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2


(Homo sapiens (Human))		BDBM50365286
PNG
(CHEMBL1958367)
Show SMILES CCn1nc2c(OC3(CCN(CC3)C(=O)c3ccc4[nH]ncc4c3)CC2=O)c1C
Show InChI InChI=1S/C21H23N5O3/c1-3-26-13(2)19-18(24-26)17(27)11-21(29-19)6-8-25(9-7-21)20(28)14-4-5-16-15(10-14)12-22-23-16/h4-5,10,12H,3,6-9,11H2,1-2H3,(H,22,23)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 92n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human Acetyl-CoA carboxylase 2 expressed in CHO cells after 1 hr by fluorescence assay

J Med Chem 55: 935-42 (2012)


Article DOI: 10.1021/jm201503u
BindingDB Entry DOI: 10.7270/Q2CZ37MS
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1


(Rattus norvegicus (Rat))		BDBM50365286
PNG
(CHEMBL1958367)
Show SMILES CCn1nc2c(OC3(CCN(CC3)C(=O)c3ccc4[nH]ncc4c3)CC2=O)c1C
Show InChI InChI=1S/C21H23N5O3/c1-3-26-13(2)19-18(24-26)17(27)11-21(29-19)6-8-25(9-7-21)20(28)14-4-5-16-15(10-14)12-22-23-16/h4-5,10,12H,3,6-9,11H2,1-2H3,(H,22,23)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 100n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...

J Med Chem 55: 935-42 (2012)


Article DOI: 10.1021/jm201503u
BindingDB Entry DOI: 10.7270/Q2CZ37MS
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1


(Rattus norvegicus (Rat))		BDBM50365275
PNG
(CHEMBL1958357)
Show SMILES Cc1cc(cc2cn[nH]c12)C(=O)N1CCC2(CC1)CC(=O)c1nn(Cc3ccccc3)cc1O2
Show InChI InChI=1S/C26H25N5O3/c1-17-11-19(12-20-14-27-28-23(17)20)25(33)30-9-7-26(8-10-30)13-21(32)24-22(34-26)16-31(29-24)15-18-5-3-2-4-6-18/h2-6,11-12,14,16H,7-10,13,15H2,1H3,(H,27,28)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 260n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...

J Med Chem 55: 935-42 (2012)


Article DOI: 10.1021/jm201503u
BindingDB Entry DOI: 10.7270/Q2CZ37MS
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1


(Rattus norvegicus (Rat))		BDBM50365270
PNG
(CHEMBL1958352)
Show SMILES Cc1c2OC3(CCN(CC3)C(=O)c3cc(C)c4[nH]ncc4c3)CC(=O)c2nn1C
Show InChI InChI=1S/C21H23N5O3/c1-12-8-14(9-15-11-22-23-17(12)15)20(28)26-6-4-21(5-7-26)10-16(27)18-19(29-21)13(2)25(3)24-18/h8-9,11H,4-7,10H2,1-3H3,(H,22,23)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 280n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...

J Med Chem 55: 935-42 (2012)


Article DOI: 10.1021/jm201503u
BindingDB Entry DOI: 10.7270/Q2CZ37MS
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1


(Rattus norvegicus (Rat))		BDBM50365269
PNG
(CHEMBL1958351)
Show SMILES Cc1cc(cc2cn[nH]c12)C(=O)N1CCC2(CC1)CC(=O)c1nn(C)cc1O2
Show InChI InChI=1S/C20H21N5O3/c1-12-7-13(8-14-10-21-22-17(12)14)19(27)25-5-3-20(4-6-25)9-15(26)18-16(28-20)11-24(2)23-18/h7-8,10-11H,3-6,9H2,1-2H3,(H,21,22)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 370n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...

J Med Chem 55: 935-42 (2012)


Article DOI: 10.1021/jm201503u
BindingDB Entry DOI: 10.7270/Q2CZ37MS
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2


(Homo sapiens (Human))		BDBM50365270
PNG
(CHEMBL1958352)
Show SMILES Cc1c2OC3(CCN(CC3)C(=O)c3cc(C)c4[nH]ncc4c3)CC(=O)c2nn1C
Show InChI InChI=1S/C21H23N5O3/c1-12-8-14(9-15-11-22-23-17(12)15)20(28)26-6-4-21(5-7-26)10-16(27)18-19(29-21)13(2)25(3)24-18/h8-9,11H,4-7,10H2,1-3H3,(H,22,23)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 470n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human Acetyl-CoA carboxylase 2 expressed in CHO cells after 1 hr by fluorescence assay

J Med Chem 55: 935-42 (2012)


Article DOI: 10.1021/jm201503u
BindingDB Entry DOI: 10.7270/Q2CZ37MS
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2


(Homo sapiens (Human))		BDBM50365269
PNG
(CHEMBL1958351)
Show SMILES Cc1cc(cc2cn[nH]c12)C(=O)N1CCC2(CC1)CC(=O)c1nn(C)cc1O2
Show InChI InChI=1S/C20H21N5O3/c1-12-7-13(8-14-10-21-22-17(12)14)19(27)25-5-3-20(4-6-25)9-15(26)18-16(28-20)11-24(2)23-18/h7-8,10-11H,3-6,9H2,1-2H3,(H,21,22)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 650n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human Acetyl-CoA carboxylase 2 expressed in CHO cells after 1 hr by fluorescence assay

J Med Chem 55: 935-42 (2012)


Article DOI: 10.1021/jm201503u
BindingDB Entry DOI: 10.7270/Q2CZ37MS
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%