Found 38 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50362567
(CHEMBL1313991)Show InChI InChI=1S/C15H19N3OS/c1-15(2,3)11-6-4-10(5-7-11)9-20-14-17-12(16)8-13(19)18-14/h4-8H,9H2,1-3H3,(H3,16,17,18,19) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| >1.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Displacement of dofetilide from human ERG |
Bioorg Med Chem Lett 22: 1055-60 (2012)
Article DOI: 10.1016/j.bmcl.2011.11.111
BindingDB Entry DOI: 10.7270/Q2CV4J7X |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50362580
(CHEMBL1938867)Show InChI InChI=1S/C16H21N3OS/c1-16(2,3)12-7-5-11(6-8-12)10-21-15-18-13(17)9-14(20)19(15)4/h5-9H,10,17H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >1.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Displacement of dofetilide from human ERG |
Bioorg Med Chem Lett 22: 1055-60 (2012)
Article DOI: 10.1016/j.bmcl.2011.11.111
BindingDB Entry DOI: 10.7270/Q2CV4J7X |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50362558
(CHEMBL1425238)Show InChI InChI=1S/C11H19N3OS/c1-2-3-4-5-6-7-16-11-13-9(12)8-10(15)14-11/h8H,2-7H2,1H3,(H3,12,13,14,15) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >1.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Displacement of dofetilide from human ERG |
Bioorg Med Chem Lett 22: 1055-60 (2012)
Article DOI: 10.1016/j.bmcl.2011.11.111
BindingDB Entry DOI: 10.7270/Q2CV4J7X |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50362580
(CHEMBL1938867)Show InChI InChI=1S/C16H21N3OS/c1-16(2,3)12-7-5-11(6-8-12)10-21-15-18-13(17)9-14(20)19(15)4/h5-9H,10,17H2,1-4H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at 20% inactivated human sodium channel Nav1.7 expressed in human HEK293 cells by manual patch-clamp electrophysiological assay |
Bioorg Med Chem Lett 22: 1055-60 (2012)
Article DOI: 10.1016/j.bmcl.2011.11.111
BindingDB Entry DOI: 10.7270/Q2CV4J7X |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 5 subunit alpha
(Homo sapiens (Human)) | BDBM50362580
(CHEMBL1938867)Show InChI InChI=1S/C16H21N3OS/c1-16(2,3)12-7-5-11(6-8-12)10-21-15-18-13(17)9-14(20)19(15)4/h5-9H,10,17H2,1-4H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at partially inactivated human sodium channel Nav1.5 expressed in human HEK293 cells by patch-clamp electrophysiological assay |
Bioorg Med Chem Lett 22: 1055-60 (2012)
Article DOI: 10.1016/j.bmcl.2011.11.111
BindingDB Entry DOI: 10.7270/Q2CV4J7X |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 5 subunit alpha
(Homo sapiens (Human)) | BDBM50362567
(CHEMBL1313991)Show InChI InChI=1S/C15H19N3OS/c1-15(2,3)11-6-4-10(5-7-11)9-20-14-17-12(16)8-13(19)18-14/h4-8H,9H2,1-3H3,(H3,16,17,18,19) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at partially inactivated human sodium channel Nav1.5 expressed in human HEK293 cells by patch-clamp electrophysiological assay |
Bioorg Med Chem Lett 22: 1055-60 (2012)
Article DOI: 10.1016/j.bmcl.2011.11.111
BindingDB Entry DOI: 10.7270/Q2CV4J7X |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50362567
(CHEMBL1313991)Show InChI InChI=1S/C15H19N3OS/c1-15(2,3)11-6-4-10(5-7-11)9-20-14-17-12(16)8-13(19)18-14/h4-8H,9H2,1-3H3,(H3,16,17,18,19) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 340 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at 20% inactivated human sodium channel Nav1.7 expressed in human HEK293 cells by manual patch-clamp electrophysiological assay |
Bioorg Med Chem Lett 22: 1055-60 (2012)
Article DOI: 10.1016/j.bmcl.2011.11.111
BindingDB Entry DOI: 10.7270/Q2CV4J7X |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50362558
(CHEMBL1425238)Show InChI InChI=1S/C11H19N3OS/c1-2-3-4-5-6-7-16-11-13-9(12)8-10(15)14-11/h8H,2-7H2,1H3,(H3,12,13,14,15) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at 20% inactivated human sodium channel Nav1.7 expressed in human HEK293 cells by manual patch-clamp electrophysiological assay |
Bioorg Med Chem Lett 22: 1055-60 (2012)
Article DOI: 10.1016/j.bmcl.2011.11.111
BindingDB Entry DOI: 10.7270/Q2CV4J7X |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50362580
(CHEMBL1938867)Show InChI InChI=1S/C16H21N3OS/c1-16(2,3)12-7-5-11(6-8-12)10-21-15-18-13(17)9-14(20)19(15)4/h5-9H,10,17H2,1-4H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 420 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at 20% inactivated human sodium channel Nav1.7 expressed in human HEK293 cells by patch-clamp electrophysiological assay |
Bioorg Med Chem Lett 22: 1055-60 (2012)
Article DOI: 10.1016/j.bmcl.2011.11.111
BindingDB Entry DOI: 10.7270/Q2CV4J7X |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50362580
(CHEMBL1938867)Show InChI InChI=1S/C16H21N3OS/c1-16(2,3)12-7-5-11(6-8-12)10-21-15-18-13(17)9-14(20)19(15)4/h5-9H,10,17H2,1-4H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at non-inactivated human sodium channel Nav1.7 expressed in human HEK293 cells by manual patch-clamp electrophysiological assay |
Bioorg Med Chem Lett 22: 1055-60 (2012)
Article DOI: 10.1016/j.bmcl.2011.11.111
BindingDB Entry DOI: 10.7270/Q2CV4J7X |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50362567
(CHEMBL1313991)Show InChI InChI=1S/C15H19N3OS/c1-15(2,3)11-6-4-10(5-7-11)9-20-14-17-12(16)8-13(19)18-14/h4-8H,9H2,1-3H3,(H3,16,17,18,19) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 680 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at 20% inactivated human sodium channel Nav1.7 expressed in human HEK293 cells by patch-clamp electrophysiological assay |
Bioorg Med Chem Lett 22: 1055-60 (2012)
Article DOI: 10.1016/j.bmcl.2011.11.111
BindingDB Entry DOI: 10.7270/Q2CV4J7X |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50362558
(CHEMBL1425238)Show InChI InChI=1S/C11H19N3OS/c1-2-3-4-5-6-7-16-11-13-9(12)8-10(15)14-11/h8H,2-7H2,1H3,(H3,12,13,14,15) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 940 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at 20% inactivated human sodium channel Nav1.7 expressed in human HEK293 cells by patch-clamp electrophysiological assay |
Bioorg Med Chem Lett 22: 1055-60 (2012)
Article DOI: 10.1016/j.bmcl.2011.11.111
BindingDB Entry DOI: 10.7270/Q2CV4J7X |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 5 subunit alpha
(Homo sapiens (Human)) | BDBM50362558
(CHEMBL1425238)Show InChI InChI=1S/C11H19N3OS/c1-2-3-4-5-6-7-16-11-13-9(12)8-10(15)14-11/h8H,2-7H2,1H3,(H3,12,13,14,15) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at partially inactivated human sodium channel Nav1.5 expressed in human HEK293 cells by patch-clamp electrophysiological assay |
Bioorg Med Chem Lett 22: 1055-60 (2012)
Article DOI: 10.1016/j.bmcl.2011.11.111
BindingDB Entry DOI: 10.7270/Q2CV4J7X |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50362573
(CHEMBL1938861)Show SMILES CC(=O)Nc1cc(=O)[nH]c(SCc2ccc(cc2)C(C)(C)C)n1 Show InChI InChI=1S/C17H21N3O2S/c1-11(21)18-14-9-15(22)20-16(19-14)23-10-12-5-7-13(8-6-12)17(2,3)4/h5-9H,10H2,1-4H3,(H2,18,19,20,21,22) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at 20% inactivated human sodium channel Nav1.7 expressed in human HEK293 cells by patch-clamp electrophysiological assay |
Bioorg Med Chem Lett 22: 1055-60 (2012)
Article DOI: 10.1016/j.bmcl.2011.11.111
BindingDB Entry DOI: 10.7270/Q2CV4J7X |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50362559
(CHEMBL82804)Show InChI InChI=1S/C10H17N3OS/c1-2-3-4-5-6-15-10-12-8(11)7-9(14)13-10/h7H,2-6H2,1H3,(H3,11,12,13,14) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at 20% inactivated human sodium channel Nav1.7 expressed in human HEK293 cells by patch-clamp electrophysiological assay |
Bioorg Med Chem Lett 22: 1055-60 (2012)
Article DOI: 10.1016/j.bmcl.2011.11.111
BindingDB Entry DOI: 10.7270/Q2CV4J7X |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50362558
(CHEMBL1425238)Show InChI InChI=1S/C11H19N3OS/c1-2-3-4-5-6-7-16-11-13-9(12)8-10(15)14-11/h8H,2-7H2,1H3,(H3,12,13,14,15) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at non-inactivated human sodium channel Nav1.7 expressed in human HEK293 cells by manual patch-clamp electrophysiological assay |
Bioorg Med Chem Lett 22: 1055-60 (2012)
Article DOI: 10.1016/j.bmcl.2011.11.111
BindingDB Entry DOI: 10.7270/Q2CV4J7X |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50362567
(CHEMBL1313991)Show InChI InChI=1S/C15H19N3OS/c1-15(2,3)11-6-4-10(5-7-11)9-20-14-17-12(16)8-13(19)18-14/h4-8H,9H2,1-3H3,(H3,16,17,18,19) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at non-inactivated human sodium channel Nav1.7 expressed in human HEK293 cells by manual patch-clamp electrophysiological assay |
Bioorg Med Chem Lett 22: 1055-60 (2012)
Article DOI: 10.1016/j.bmcl.2011.11.111
BindingDB Entry DOI: 10.7270/Q2CV4J7X |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50362566
(CHEMBL1938856)Show InChI InChI=1S/C12H10F3N3O2S/c13-12(14,15)20-8-3-1-7(2-4-8)6-21-11-17-9(16)5-10(19)18-11/h1-5H,6H2,(H3,16,17,18,19) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at 20% inactivated human sodium channel Nav1.7 expressed in human HEK293 cells by patch-clamp electrophysiological assay |
Bioorg Med Chem Lett 22: 1055-60 (2012)
Article DOI: 10.1016/j.bmcl.2011.11.111
BindingDB Entry DOI: 10.7270/Q2CV4J7X |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50362574
(CHEMBL1938401)Show SMILES CC(C)(C)c1ccc(CSc2nc(NC(=O)C3CC3)cc(=O)[nH]2)cc1 Show InChI InChI=1S/C19H23N3O2S/c1-19(2,3)14-8-4-12(5-9-14)11-25-18-21-15(10-16(23)22-18)20-17(24)13-6-7-13/h4-5,8-10,13H,6-7,11H2,1-3H3,(H2,20,21,22,23,24) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at 20% inactivated human sodium channel Nav1.7 expressed in human HEK293 cells by patch-clamp electrophysiological assay |
Bioorg Med Chem Lett 22: 1055-60 (2012)
Article DOI: 10.1016/j.bmcl.2011.11.111
BindingDB Entry DOI: 10.7270/Q2CV4J7X |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50362565
(CHEMBL1938855)Show InChI InChI=1S/C12H10F3N3OS/c13-12(14,15)8-3-1-7(2-4-8)6-20-11-17-9(16)5-10(19)18-11/h1-5H,6H2,(H3,16,17,18,19) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at 20% inactivated human sodium channel Nav1.7 expressed in human HEK293 cells by patch-clamp electrophysiological assay |
Bioorg Med Chem Lett 22: 1055-60 (2012)
Article DOI: 10.1016/j.bmcl.2011.11.111
BindingDB Entry DOI: 10.7270/Q2CV4J7X |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50362577
(CHEMBL1938864)Show InChI InChI=1S/C15H18ClN3OS/c1-15(2,3)10-6-4-9(5-7-10)8-21-14-18-12(17)11(16)13(20)19-14/h4-7H,8H2,1-3H3,(H3,17,18,19,20) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at 20% inactivated human sodium channel Nav1.7 expressed in human HEK293 cells by patch-clamp electrophysiological assay |
Bioorg Med Chem Lett 22: 1055-60 (2012)
Article DOI: 10.1016/j.bmcl.2011.11.111
BindingDB Entry DOI: 10.7270/Q2CV4J7X |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50362563
(CHEMBL1346856)Show InChI InChI=1S/C11H10ClN3OS/c12-8-3-1-7(2-4-8)6-17-11-14-9(13)5-10(16)15-11/h1-5H,6H2,(H3,13,14,15,16) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at 20% inactivated human sodium channel Nav1.7 expressed in human HEK293 cells by patch-clamp electrophysiological assay |
Bioorg Med Chem Lett 22: 1055-60 (2012)
Article DOI: 10.1016/j.bmcl.2011.11.111
BindingDB Entry DOI: 10.7270/Q2CV4J7X |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50362564
(CHEMBL1479024)Show InChI InChI=1S/C12H13N3OS/c1-8-2-4-9(5-3-8)7-17-12-14-10(13)6-11(16)15-12/h2-6H,7H2,1H3,(H3,13,14,15,16) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 5.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at 20% inactivated human sodium channel Nav1.7 expressed in human HEK293 cells by patch-clamp electrophysiological assay |
Bioorg Med Chem Lett 22: 1055-60 (2012)
Article DOI: 10.1016/j.bmcl.2011.11.111
BindingDB Entry DOI: 10.7270/Q2CV4J7X |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50362575
(CHEMBL1938862)Show SMILES CC(C)(C)OC(=O)Nc1cc(=O)[nH]c(SCc2ccc(cc2)C(C)(C)C)n1 Show InChI InChI=1S/C20H27N3O3S/c1-19(2,3)14-9-7-13(8-10-14)12-27-17-21-15(11-16(24)23-17)22-18(25)26-20(4,5)6/h7-11H,12H2,1-6H3,(H2,21,22,23,24,25) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 7.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at 20% inactivated human sodium channel Nav1.7 expressed in human HEK293 cells by patch-clamp electrophysiological assay |
Bioorg Med Chem Lett 22: 1055-60 (2012)
Article DOI: 10.1016/j.bmcl.2011.11.111
BindingDB Entry DOI: 10.7270/Q2CV4J7X |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50362561
(CHEMBL1938853)Show InChI InChI=1S/C11H11N3OS/c12-9-6-10(15)14-11(13-9)16-7-8-4-2-1-3-5-8/h1-6H,7H2,(H3,12,13,14,15) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at 20% inactivated human sodium channel Nav1.7 expressed in human HEK293 cells by patch-clamp electrophysiological assay |
Bioorg Med Chem Lett 22: 1055-60 (2012)
Article DOI: 10.1016/j.bmcl.2011.11.111
BindingDB Entry DOI: 10.7270/Q2CV4J7X |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50362572
(CHEMBL1938860)Show InChI InChI=1S/C15H18N2O2S/c1-15(2,3)11-6-4-10(5-7-11)9-20-14-16-12(18)8-13(19)17-14/h4-8H,9H2,1-3H3,(H2,16,17,18,19) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at 20% inactivated human sodium channel Nav1.7 expressed in human HEK293 cells by patch-clamp electrophysiological assay |
Bioorg Med Chem Lett 22: 1055-60 (2012)
Article DOI: 10.1016/j.bmcl.2011.11.111
BindingDB Entry DOI: 10.7270/Q2CV4J7X |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50362570
(CHEMBL1702732)Show InChI InChI=1S/C12H10N4OS/c13-6-8-1-3-9(4-2-8)7-18-12-15-10(14)5-11(17)16-12/h1-5H,7H2,(H3,14,15,16,17) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at 20% inactivated human sodium channel Nav1.7 expressed in human HEK293 cells by patch-clamp electrophysiological assay |
Bioorg Med Chem Lett 22: 1055-60 (2012)
Article DOI: 10.1016/j.bmcl.2011.11.111
BindingDB Entry DOI: 10.7270/Q2CV4J7X |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50362582
(CHEMBL1938869)Show InChI InChI=1S/C16H21N3OS/c1-16(2,3)12-7-5-11(6-8-12)10-21-15-18-14(20)9-13(17)19(15)4/h5-9H,10,17H2,1-4H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at 20% inactivated human sodium channel Nav1.7 expressed in human HEK293 cells by patch-clamp electrophysiological assay |
Bioorg Med Chem Lett 22: 1055-60 (2012)
Article DOI: 10.1016/j.bmcl.2011.11.111
BindingDB Entry DOI: 10.7270/Q2CV4J7X |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50362579
(CHEMBL1938866)Show SMILES CC(C)(C)c1ccc(CSc2nc3nc[nH]c3c(=O)[nH]2)cc1 Show InChI InChI=1S/C16H18N4OS/c1-16(2,3)11-6-4-10(5-7-11)8-22-15-19-13-12(14(21)20-15)17-9-18-13/h4-7,9H,8H2,1-3H3,(H2,17,18,19,20,21) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at 20% inactivated human sodium channel Nav1.7 expressed in human HEK293 cells by patch-clamp electrophysiological assay |
Bioorg Med Chem Lett 22: 1055-60 (2012)
Article DOI: 10.1016/j.bmcl.2011.11.111
BindingDB Entry DOI: 10.7270/Q2CV4J7X |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50362576
(CHEMBL1938863)Show SMILES CC(C)(C)c1ccc(CSc2nc(NS(C)(=O)=O)cc(=O)[nH]2)cc1 Show InChI InChI=1S/C16H21N3O3S2/c1-16(2,3)12-7-5-11(6-8-12)10-23-15-17-13(9-14(20)18-15)19-24(4,21)22/h5-9H,10H2,1-4H3,(H2,17,18,19,20) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at 20% inactivated human sodium channel Nav1.7 expressed in human HEK293 cells by patch-clamp electrophysiological assay |
Bioorg Med Chem Lett 22: 1055-60 (2012)
Article DOI: 10.1016/j.bmcl.2011.11.111
BindingDB Entry DOI: 10.7270/Q2CV4J7X |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50362568
(CHEMBL1938857)Show InChI InChI=1S/C17H15N3OS/c18-15-10-16(21)20-17(19-15)22-11-12-6-8-14(9-7-12)13-4-2-1-3-5-13/h1-10H,11H2,(H3,18,19,20,21) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at 20% inactivated human sodium channel Nav1.7 expressed in human HEK293 cells by patch-clamp electrophysiological assay |
Bioorg Med Chem Lett 22: 1055-60 (2012)
Article DOI: 10.1016/j.bmcl.2011.11.111
BindingDB Entry DOI: 10.7270/Q2CV4J7X |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50362581
(CHEMBL1938868)Show InChI InChI=1S/C16H21N3OS/c1-16(2,3)12-7-5-11(6-8-12)10-21-15-18-13(17)9-14(19-15)20-4/h5-9H,10H2,1-4H3,(H2,17,18,19) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at 20% inactivated human sodium channel Nav1.7 expressed in human HEK293 cells by patch-clamp electrophysiological assay |
Bioorg Med Chem Lett 22: 1055-60 (2012)
Article DOI: 10.1016/j.bmcl.2011.11.111
BindingDB Entry DOI: 10.7270/Q2CV4J7X |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50362571
(CHEMBL1938859)Show InChI InChI=1S/C15H18N2OS/c1-15(2,3)12-6-4-11(5-7-12)10-19-14-16-9-8-13(18)17-14/h4-9H,10H2,1-3H3,(H,16,17,18) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at 20% inactivated human sodium channel Nav1.7 expressed in human HEK293 cells by patch-clamp electrophysiological assay |
Bioorg Med Chem Lett 22: 1055-60 (2012)
Article DOI: 10.1016/j.bmcl.2011.11.111
BindingDB Entry DOI: 10.7270/Q2CV4J7X |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50362578
(CHEMBL1938865)Show InChI InChI=1S/C15H20N4OS/c1-15(2,3)10-6-4-9(5-7-10)8-21-14-18-12(17)11(16)13(20)19-14/h4-7H,8,16H2,1-3H3,(H3,17,18,19,20) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at 20% inactivated human sodium channel Nav1.7 expressed in human HEK293 cells by patch-clamp electrophysiological assay |
Bioorg Med Chem Lett 22: 1055-60 (2012)
Article DOI: 10.1016/j.bmcl.2011.11.111
BindingDB Entry DOI: 10.7270/Q2CV4J7X |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50362560
(CHEMBL1938852)Show InChI InChI=1S/C8H13N3OS/c1-5(2)4-13-8-10-6(9)3-7(12)11-8/h3,5H,4H2,1-2H3,(H3,9,10,11,12) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at 20% inactivated human sodium channel Nav1.7 expressed in human HEK293 cells by patch-clamp electrophysiological assay |
Bioorg Med Chem Lett 22: 1055-60 (2012)
Article DOI: 10.1016/j.bmcl.2011.11.111
BindingDB Entry DOI: 10.7270/Q2CV4J7X |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50362569
(CHEMBL1938858)Show InChI InChI=1S/C12H13N3O3S2/c1-20(17,18)9-4-2-8(3-5-9)7-19-12-14-10(13)6-11(16)15-12/h2-6H,7H2,1H3,(H3,13,14,15,16) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at 20% inactivated human sodium channel Nav1.7 expressed in human HEK293 cells by patch-clamp electrophysiological assay |
Bioorg Med Chem Lett 22: 1055-60 (2012)
Article DOI: 10.1016/j.bmcl.2011.11.111
BindingDB Entry DOI: 10.7270/Q2CV4J7X |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50362562
(CHEMBL1938854)Show InChI InChI=1S/C11H10FN3OS/c12-8-3-1-7(2-4-8)6-17-11-14-9(13)5-10(16)15-11/h1-5H,6H2,(H3,13,14,15,16) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at 20% inactivated human sodium channel Nav1.7 expressed in human HEK293 cells by patch-clamp electrophysiological assay |
Bioorg Med Chem Lett 22: 1055-60 (2012)
Article DOI: 10.1016/j.bmcl.2011.11.111
BindingDB Entry DOI: 10.7270/Q2CV4J7X |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50117271
(1-(2,6-dimethylphenoxy)-2-propanolamine | 1-(2,6-d...)Show InChI InChI=1S/C11H17NO/c1-8-5-4-6-9(2)11(8)13-7-10(3)12/h4-6,10H,7,12H2,1-3H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
KEGG
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 5.60E+7 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at 20% inactivated human sodium channel Nav1.7 expressed in human HEK293 cells by patch-clamp electrophysiological assay |
Bioorg Med Chem Lett 22: 1055-60 (2012)
Article DOI: 10.1016/j.bmcl.2011.11.111
BindingDB Entry DOI: 10.7270/Q2CV4J7X |
More data for this
Ligand-Target Pair | |
Search and Browse
