Found 21 hits of Enzyme Inhibition Constant Data Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Free fatty acid receptor 1
(Mus musculus) | BDBM50362690
(AMG-837 | CHEMBL1829173)Show SMILES CC#C[C@@H](CC(O)=O)c1ccc(OCc2cccc(c2)-c2ccc(cc2)C(F)(F)F)cc1 |r| Show InChI InChI=1S/C26H21F3O3/c1-2-4-21(16-25(30)31)20-9-13-24(14-10-20)32-17-18-5-3-6-22(15-18)19-7-11-23(12-8-19)26(27,28)29/h3,5-15,21H,16-17H2,1H3,(H,30,31)/t21-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 13 | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Agonist activity at mouse GPR40 |
Bioorg Med Chem Lett 22: 1267-70 (2012)
Article DOI: 10.1016/j.bmcl.2011.10.118 BindingDB Entry DOI: 10.7270/Q2MC90GP |
More data for this Ligand-Target Pair | |
Free fatty acid receptor 1
(Homo sapiens (Human)) | BDBM50362696
(CHEMBL1939642)Show SMILES [#6]-[#8]-c1ccc(-[#6]-[#8]-c2ccc(cc2)-[#6](\[#6]-[#6](-[#8])=O)=[#6](\[#6])-[#6])cc1 Show InChI InChI=1S/C20H22O4/c1-14(2)19(12-20(21)22)16-6-10-18(11-7-16)24-13-15-4-8-17(23-3)9-5-15/h4-11H,12-13H2,1-3H3,(H,21,22) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assay |
Bioorg Med Chem Lett 22: 1267-70 (2012)
Article DOI: 10.1016/j.bmcl.2011.10.118 BindingDB Entry DOI: 10.7270/Q2MC90GP |
More data for this Ligand-Target Pair | |
Free fatty acid receptor 1
(Homo sapiens (Human)) | BDBM50362705
(CHEMBL1939651)Show SMILES CC#CC(CC(O)=O)c1ccc(OCc2ccc(cc2)-c2ccccc2)cc1 Show InChI InChI=1S/C25H22O3/c1-2-6-23(17-25(26)27)22-13-15-24(16-14-22)28-18-19-9-11-21(12-10-19)20-7-4-3-5-8-20/h3-5,7-16,23H,17-18H2,1H3,(H,26,27) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assay |
Bioorg Med Chem Lett 22: 1267-70 (2012)
Article DOI: 10.1016/j.bmcl.2011.10.118 BindingDB Entry DOI: 10.7270/Q2MC90GP |
More data for this Ligand-Target Pair | |
Free fatty acid receptor 1
(Homo sapiens (Human)) | BDBM50362707
(CHEMBL1939653)Show SMILES CC#CC(CC(O)=O)c1ccc(OCc2cccc(c2)-c2ccccc2)cc1 Show InChI InChI=1S/C25H22O3/c1-2-7-22(17-25(26)27)21-12-14-24(15-13-21)28-18-19-8-6-11-23(16-19)20-9-4-3-5-10-20/h3-6,8-16,22H,17-18H2,1H3,(H,26,27) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 58 | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assay |
Bioorg Med Chem Lett 22: 1267-70 (2012)
Article DOI: 10.1016/j.bmcl.2011.10.118 BindingDB Entry DOI: 10.7270/Q2MC90GP |
More data for this Ligand-Target Pair | |
Free fatty acid receptor 1
(Homo sapiens (Human)) | BDBM50362691
(CHEMBL1939637)Show InChI InChI=1S/C17H18O4/c1-20-15-7-4-14(5-8-15)12-21-16-9-2-13(3-10-16)6-11-17(18)19/h2-5,7-10H,6,11-12H2,1H3,(H,18,19) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assay |
Bioorg Med Chem Lett 22: 1267-70 (2012)
Article DOI: 10.1016/j.bmcl.2011.10.118 BindingDB Entry DOI: 10.7270/Q2MC90GP |
More data for this Ligand-Target Pair | |
Free fatty acid receptor 1
(Homo sapiens (Human)) | BDBM50362692
(CHEMBL1939638)Show InChI InChI=1S/C19H22O4/c1-3-15(12-19(20)21)16-6-10-18(11-7-16)23-13-14-4-8-17(22-2)9-5-14/h4-11,15H,3,12-13H2,1-2H3,(H,20,21) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 3.20E+3 | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assay |
Bioorg Med Chem Lett 22: 1267-70 (2012)
Article DOI: 10.1016/j.bmcl.2011.10.118 BindingDB Entry DOI: 10.7270/Q2MC90GP |
More data for this Ligand-Target Pair | |
Free fatty acid receptor 1
(Homo sapiens (Human)) | BDBM50362700
(CHEMBL1939646)Show InChI InChI=1S/C19H18O3/c1-2-6-17(13-19(20)21)16-9-11-18(12-10-16)22-14-15-7-4-3-5-8-15/h3-5,7-12,17H,13-14H2,1H3,(H,20,21) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 620 | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assay |
Bioorg Med Chem Lett 22: 1267-70 (2012)
Article DOI: 10.1016/j.bmcl.2011.10.118 BindingDB Entry DOI: 10.7270/Q2MC90GP |
More data for this Ligand-Target Pair | |
Free fatty acid receptor 1
(Homo sapiens (Human)) | BDBM50362695
(CHEMBL1939641)Show SMILES [#6]-[#8]-c1ccc(-[#6]-[#8]-c2ccc(cc2)-[#6](-[#6]-[#6](-[#8])=O)\[#6]=[#6](\[#6])-[#6])cc1 Show InChI InChI=1S/C21H24O4/c1-15(2)12-18(13-21(22)23)17-6-10-20(11-7-17)25-14-16-4-8-19(24-3)9-5-16/h4-12,18H,13-14H2,1-3H3,(H,22,23) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 120 | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assay |
Bioorg Med Chem Lett 22: 1267-70 (2012)
Article DOI: 10.1016/j.bmcl.2011.10.118 BindingDB Entry DOI: 10.7270/Q2MC90GP |
More data for this Ligand-Target Pair | |
Free fatty acid receptor 1
(Homo sapiens (Human)) | BDBM50362702
(CHEMBL1939648)Show InChI InChI=1S/C20H20O3/c1-3-4-18(13-20(21)22)17-9-11-19(12-10-17)23-14-16-7-5-15(2)6-8-16/h5-12,18H,13-14H2,1-2H3,(H,21,22) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 180 | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assay |
Bioorg Med Chem Lett 22: 1267-70 (2012)
Article DOI: 10.1016/j.bmcl.2011.10.118 BindingDB Entry DOI: 10.7270/Q2MC90GP |
More data for this Ligand-Target Pair | |
Free fatty acid receptor 1
(Homo sapiens (Human)) | BDBM50362698
(CHEMBL1939644)Show SMILES COc1ccc(COc2ccc(cc2)[C@@H](CC(O)=O)C#CC)cc1 |r| Show InChI InChI=1S/C20H20O4/c1-3-4-17(13-20(21)22)16-7-11-19(12-8-16)24-14-15-5-9-18(23-2)10-6-15/h5-12,17H,13-14H2,1-2H3,(H,21,22)/t17-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 6.70E+3 | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assay |
Bioorg Med Chem Lett 22: 1267-70 (2012)
Article DOI: 10.1016/j.bmcl.2011.10.118 BindingDB Entry DOI: 10.7270/Q2MC90GP |
More data for this Ligand-Target Pair | |
Free fatty acid receptor 1
(Homo sapiens (Human)) | BDBM50362701
(CHEMBL1939647)Show InChI InChI=1S/C20H20O3/c1-2-6-18(15-20(21)22)17-9-11-19(12-10-17)23-14-13-16-7-4-3-5-8-16/h3-5,7-12,18H,13-15H2,1H3,(H,21,22) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | n/a | n/a | 6.20E+3 | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assay |
Bioorg Med Chem Lett 22: 1267-70 (2012)
Article DOI: 10.1016/j.bmcl.2011.10.118 BindingDB Entry DOI: 10.7270/Q2MC90GP |
More data for this Ligand-Target Pair | |
Free fatty acid receptor 1
(Homo sapiens (Human)) | BDBM50362703
(CHEMBL1939649)Show SMILES CC#CC(CC(O)=O)c1ccc(OCc2ccc(cc2)C(F)(F)F)cc1 Show InChI InChI=1S/C20H17F3O3/c1-2-3-16(12-19(24)25)15-6-10-18(11-7-15)26-13-14-4-8-17(9-5-14)20(21,22)23/h4-11,16H,12-13H2,1H3,(H,24,25) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 2.70E+4 | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assay |
Bioorg Med Chem Lett 22: 1267-70 (2012)
Article DOI: 10.1016/j.bmcl.2011.10.118 BindingDB Entry DOI: 10.7270/Q2MC90GP |
More data for this Ligand-Target Pair | |
Free fatty acid receptor 1
(Homo sapiens (Human)) | BDBM50362699
(CHEMBL1939645)Show SMILES COc1ccc(COc2ccc(cc2)[C@H](CC(O)=O)C#CC)cc1 |r| Show InChI InChI=1S/C20H20O4/c1-3-4-17(13-20(21)22)16-7-11-19(12-8-16)24-14-15-5-9-18(23-2)10-6-15/h5-12,17H,13-14H2,1-2H3,(H,21,22)/t17-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 64 | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assay |
Bioorg Med Chem Lett 22: 1267-70 (2012)
Article DOI: 10.1016/j.bmcl.2011.10.118 BindingDB Entry DOI: 10.7270/Q2MC90GP |
More data for this Ligand-Target Pair | |
Free fatty acid receptor 1
(Homo sapiens (Human)) | BDBM50362704
(CHEMBL1939650)Show InChI InChI=1S/C20H20O4/c1-3-5-17(13-20(21)22)16-8-10-18(11-9-16)24-14-15-6-4-7-19(12-15)23-2/h4,6-12,17H,13-14H2,1-2H3,(H,21,22) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 110 | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assay |
Bioorg Med Chem Lett 22: 1267-70 (2012)
Article DOI: 10.1016/j.bmcl.2011.10.118 BindingDB Entry DOI: 10.7270/Q2MC90GP |
More data for this Ligand-Target Pair | |
Free fatty acid receptor 1
(Homo sapiens (Human)) | BDBM50362694
(CHEMBL1939640)Show SMILES COc1ccc(COc2ccc(cc2)C(CC(O)=O)c2ccc(F)cc2)cc1 Show InChI InChI=1S/C23H21FO4/c1-27-20-10-2-16(3-11-20)15-28-21-12-6-18(7-13-21)22(14-23(25)26)17-4-8-19(24)9-5-17/h2-13,22H,14-15H2,1H3,(H,25,26) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | n/a | n/a | 580 | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assay |
Bioorg Med Chem Lett 22: 1267-70 (2012)
Article DOI: 10.1016/j.bmcl.2011.10.118 BindingDB Entry DOI: 10.7270/Q2MC90GP |
More data for this Ligand-Target Pair | |
Free fatty acid receptor 1
(Rattus norvegicus) | BDBM50362690
(AMG-837 | CHEMBL1829173)Show SMILES CC#C[C@@H](CC(O)=O)c1ccc(OCc2cccc(c2)-c2ccc(cc2)C(F)(F)F)cc1 |r| Show InChI InChI=1S/C26H21F3O3/c1-2-4-21(16-25(30)31)20-9-13-24(14-10-20)32-17-18-5-3-6-22(15-18)19-7-11-23(12-8-19)26(27,28)29/h3,5-15,21H,16-17H2,1H3,(H,30,31)/t21-/m0/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 23 | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Agonist activity at rat GPR40 |
Bioorg Med Chem Lett 22: 1267-70 (2012)
Article DOI: 10.1016/j.bmcl.2011.10.118 BindingDB Entry DOI: 10.7270/Q2MC90GP |
More data for this Ligand-Target Pair | |
Free fatty acid receptor 1
(Homo sapiens (Human)) | BDBM50362693
(CHEMBL1939639)Show InChI InChI=1S/C19H20O4/c1-3-15(12-19(20)21)16-6-10-18(11-7-16)23-13-14-4-8-17(22-2)9-5-14/h3-11,15H,1,12-13H2,2H3,(H,20,21) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 900 | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assay |
Bioorg Med Chem Lett 22: 1267-70 (2012)
Article DOI: 10.1016/j.bmcl.2011.10.118 BindingDB Entry DOI: 10.7270/Q2MC90GP |
More data for this Ligand-Target Pair | |
Free fatty acid receptor 1
(Homo sapiens (Human)) | BDBM50362706
(CHEMBL1939652)Show SMILES CC#CC(CC(O)=O)c1ccc(OCc2ccccc2-c2ccccc2)cc1 Show InChI InChI=1S/C25H22O3/c1-2-8-21(17-25(26)27)19-13-15-23(16-14-19)28-18-22-11-6-7-12-24(22)20-9-4-3-5-10-20/h3-7,9-16,21H,17-18H2,1H3,(H,26,27) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 240 | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assay |
Bioorg Med Chem Lett 22: 1267-70 (2012)
Article DOI: 10.1016/j.bmcl.2011.10.118 BindingDB Entry DOI: 10.7270/Q2MC90GP |
More data for this Ligand-Target Pair | |
Free fatty acid receptor 1
(Homo sapiens (Human)) | BDBM50362708
(CHEMBL1938409)Show SMILES CC#CC(CC(O)=O)c1ccc(Oc2cccc(c2)-c2ccccc2)cc1 Show InChI InChI=1S/C24H20O3/c1-2-7-20(17-24(25)26)19-12-14-22(15-13-19)27-23-11-6-10-21(16-23)18-8-4-3-5-9-18/h3-6,8-16,20H,17H2,1H3,(H,25,26) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 360 | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assay |
Bioorg Med Chem Lett 22: 1267-70 (2012)
Article DOI: 10.1016/j.bmcl.2011.10.118 BindingDB Entry DOI: 10.7270/Q2MC90GP |
More data for this Ligand-Target Pair | |
Free fatty acid receptor 1
(Homo sapiens (Human)) | BDBM50362690
(AMG-837 | CHEMBL1829173)Show SMILES CC#C[C@@H](CC(O)=O)c1ccc(OCc2cccc(c2)-c2ccc(cc2)C(F)(F)F)cc1 |r| Show InChI InChI=1S/C26H21F3O3/c1-2-4-21(16-25(30)31)20-9-13-24(14-10-20)32-17-18-5-3-6-22(15-18)19-7-11-23(12-8-19)26(27,28)29/h3,5-15,21H,16-17H2,1H3,(H,30,31)/t21-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 25 | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assay |
Bioorg Med Chem Lett 22: 1267-70 (2012)
Article DOI: 10.1016/j.bmcl.2011.10.118 BindingDB Entry DOI: 10.7270/Q2MC90GP |
More data for this Ligand-Target Pair | |
Free fatty acid receptor 1
(Homo sapiens (Human)) | BDBM50362697
(CHEMBL1939643)Show InChI InChI=1S/C20H20O4/c1-3-4-17(13-20(21)22)16-7-11-19(12-8-16)24-14-15-5-9-18(23-2)10-6-15/h5-12,17H,13-14H2,1-2H3,(H,21,22) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 260 | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assay |
Bioorg Med Chem Lett 22: 1267-70 (2012)
Article DOI: 10.1016/j.bmcl.2011.10.118 BindingDB Entry DOI: 10.7270/Q2MC90GP |
More data for this Ligand-Target Pair | |