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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Aurora kinase A (Homo sapiens (Human)) | BDBM87054 (Bisanilinopyrimidine inhibitor, 8 | Bisanilinopyri...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet  | PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 2.10 | 13 | n/a | n/a | n/a | 7.4 | 25 |
Moffitt Cancer Center and Research Institute | Assay Description The formation of ADP from ATP was quantified using a coupled enzyme assay (DiscoverX) in with a fluorescent resorufin dye is generated from the inter... | ACS Chem Biol 7: 698-706 (2012) Article DOI: 10.1021/cb200508b BindingDB Entry DOI: 10.7270/Q2PK0DRH | |||||||||||
| More data for this Ligand-Target Pair |  3D Structure (crystal) | ||||||||||||
| Aurora kinase A (Homo sapiens (Human)) | BDBM87053 (Bisanilinopyrimidine inhibitor, 7 | Bisanilinopyri...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 2.5 | 15 | n/a | n/a | n/a | 7.4 | 25 |
Moffitt Cancer Center and Research Institute | Assay Description The formation of ADP from ATP was quantified using a coupled enzyme assay (DiscoverX) in with a fluorescent resorufin dye is generated from the inter... | ACS Chem Biol 7: 698-706 (2012) Article DOI: 10.1021/cb200508b BindingDB Entry DOI: 10.7270/Q2PK0DRH | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Aurora kinase A (Homo sapiens (Human)) | BDBM13534 (CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 2.80 | 17 | n/a | n/a | n/a | 7.4 | 25 |
Moffitt Cancer Center and Research Institute | Assay Description The formation of ADP from ATP was quantified using a coupled enzyme assay (DiscoverX) in with a fluorescent resorufin dye is generated from the inter... | ACS Chem Biol 7: 698-706 (2012) Article DOI: 10.1021/cb200508b BindingDB Entry DOI: 10.7270/Q2PK0DRH | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Aurora kinase A (Homo sapiens (Human)) | BDBM87052 (Bisanilinopyrimidine inhibitor, 6 | Bisanilinopyri...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 3.70 | 16 | n/a | n/a | n/a | 7.4 | 25 |
Moffitt Cancer Center and Research Institute | Assay Description The formation of ADP from ATP was quantified using a coupled enzyme assay (DiscoverX) in with a fluorescent resorufin dye is generated from the inter... | ACS Chem Biol 7: 698-706 (2012) Article DOI: 10.1021/cb200508b BindingDB Entry DOI: 10.7270/Q2PK0DRH | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Aurora kinase A (Homo sapiens (Human)) | BDBM87048 (Bisanilinopyrimidine inhibitor, 2 | Bisanilinopyri...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 6.10 | 34 | n/a | n/a | n/a | 7.4 | 25 |
Moffitt Cancer Center and Research Institute | Assay Description The formation of ADP from ATP was quantified using a coupled enzyme assay (DiscoverX) in with a fluorescent resorufin dye is generated from the inter... | ACS Chem Biol 7: 698-706 (2012) Article DOI: 10.1021/cb200508b BindingDB Entry DOI: 10.7270/Q2PK0DRH | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Aurora kinase A (Homo sapiens (Human)) | BDBM87047 (Bisanilinopyrimidine inhibitor, 1 | Bisanilinopyri...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 10 | 39 | n/a | n/a | n/a | 7.4 | 25 |
Moffitt Cancer Center and Research Institute | Assay Description The formation of ADP from ATP was quantified using a coupled enzyme assay (DiscoverX) in with a fluorescent resorufin dye is generated from the inter... | ACS Chem Biol 7: 698-706 (2012) Article DOI: 10.1021/cb200508b BindingDB Entry DOI: 10.7270/Q2PK0DRH | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Aurora kinase A (Homo sapiens (Human)) | BDBM87051 (Bisanilinopyrimidine inhibitor, 5 | Bisanilinopyri...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 28 | 40 | n/a | n/a | n/a | 7.4 | 25 |
Moffitt Cancer Center and Research Institute | Assay Description The formation of ADP from ATP was quantified using a coupled enzyme assay (DiscoverX) in with a fluorescent resorufin dye is generated from the inter... | ACS Chem Biol 7: 698-706 (2012) Article DOI: 10.1021/cb200508b BindingDB Entry DOI: 10.7270/Q2PK0DRH | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Aurora kinase A (Homo sapiens (Human)) | BDBM87050 (Bisanilinopyrimidine inhibitor, 4 | Bisanilinopyri...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 35 | 49 | n/a | n/a | n/a | 7.4 | 25 |
Moffitt Cancer Center and Research Institute | Assay Description The formation of ADP from ATP was quantified using a coupled enzyme assay (DiscoverX) in with a fluorescent resorufin dye is generated from the inter... | ACS Chem Biol 7: 698-706 (2012) Article DOI: 10.1021/cb200508b BindingDB Entry DOI: 10.7270/Q2PK0DRH | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Aurora kinase A (Homo sapiens (Human)) | BDBM87055 (Bisanilinopyrimidine inhibitor, 9 | Bisanilinopyri...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 43 | 51 | n/a | n/a | n/a | 7.4 | 25 |
Moffitt Cancer Center and Research Institute | Assay Description The formation of ADP from ATP was quantified using a coupled enzyme assay (DiscoverX) in with a fluorescent resorufin dye is generated from the inter... | ACS Chem Biol 7: 698-706 (2012) Article DOI: 10.1021/cb200508b BindingDB Entry DOI: 10.7270/Q2PK0DRH | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Aurora kinase A (Homo sapiens (Human)) | BDBM87049 (Bisanilinopyrimidine inhibitor, 3) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 149 | 299 | n/a | n/a | n/a | 7.4 | 25 |
Moffitt Cancer Center and Research Institute | Assay Description The formation of ADP from ATP was quantified using a coupled enzyme assay (DiscoverX) in with a fluorescent resorufin dye is generated from the inter... | ACS Chem Biol 7: 698-706 (2012) Article DOI: 10.1021/cb200508b BindingDB Entry DOI: 10.7270/Q2PK0DRH | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cell (A) | Syringe (B) | Cell Links | Syringe Links | Cell + Syr Links | ΔG° kJ/mole | -TΔS° kJ/mole | ΔH° kJ/mole | log K | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|
| Serine/threonine-protein kinase Aurora-A (Homo sapiens (Human)) | BDBM87047 (Bisanilinopyrimidine inhibitor, 1 | Bisanilinopyri...) | DrugBank GoogleScholar KEGG PDB | PC cid PC sid PDB | n/a | -16.1 | -59 | n/a | 7.40 | 25 | |
Moffitt Cancer Center and Research Institute | ACS Chem Biol 7: 698-706 (2012) | |||||||||
| Serine/threonine-protein kinase Aurora-A (Homo sapiens (Human)) | BDBM87048 (Bisanilinopyrimidine inhibitor, 2 | Bisanilinopyri...) | DrugBank GoogleScholar KEGG PDB | PC cid PC sid PDB | n/a | -14.0 | -59 | n/a | 7.40 | 25 | |
Moffitt Cancer Center and Research Institute | ACS Chem Biol 7: 698-706 (2012) | |||||||||
| Serine/threonine-protein kinase Aurora-A (Homo sapiens (Human)) | BDBM87049 (Bisanilinopyrimidine inhibitor, 3) | DrugBank GoogleScholar KEGG PDB | PC cid PC sid | n/a | 23.0 | -13 | n/a | 7.40 | 25 | |
Moffitt Cancer Center and Research Institute | ACS Chem Biol 7: 698-706 (2012) | |||||||||
| Serine/threonine-protein kinase Aurora-A (Homo sapiens (Human)) | BDBM87050 (Bisanilinopyrimidine inhibitor, 4 | Bisanilinopyri...) | DrugBank GoogleScholar KEGG PDB | PC cid PC sid PDB | n/a | -17.9 | -59 | n/a | 7.40 | 25 | |
Moffitt Cancer Center and Research Institute | ACS Chem Biol 7: 698-706 (2012) | |||||||||
| Serine/threonine-protein kinase Aurora-A (Homo sapiens (Human)) | BDBM87056 (VX680) | DrugBank GoogleScholar KEGG PDB | PC cid PC sid | n/a | -8.94 | -50 | n/a | 7.40 | 25 | |
Moffitt Cancer Center and Research Institute | ACS Chem Biol 7: 698-706 (2012) | |||||||||
| Serine/threonine-protein kinase Aurora-A (Homo sapiens (Human)) | BDBM87052 (Bisanilinopyrimidine inhibitor, 6 | Bisanilinopyri...) | DrugBank GoogleScholar KEGG PDB | PC cid PC sid PDB | n/a | -25.9 | -71 | n/a | 7.40 | 25 | |
Moffitt Cancer Center and Research Institute | ACS Chem Biol 7: 698-706 (2012) | |||||||||
| Serine/threonine-protein kinase Aurora-A (Homo sapiens (Human)) | BDBM87053 (Bisanilinopyrimidine inhibitor, 7 | Bisanilinopyri...) | DrugBank GoogleScholar KEGG PDB | PC cid PC sid PDB | n/a | -25.9 | -71 | n/a | 7.40 | 25 | |
Moffitt Cancer Center and Research Institute | ACS Chem Biol 7: 698-706 (2012) | |||||||||
| Serine/threonine-protein kinase Aurora-A (Homo sapiens (Human)) | BDBM87054 (Bisanilinopyrimidine inhibitor, 8 | Bisanilinopyri...) | DrugBank GoogleScholar KEGG PDB | PC cid PC sid PDB | n/a | -17.0 | -63 | n/a | 7.40 | 25 | |
Moffitt Cancer Center and Research Institute | ACS Chem Biol 7: 698-706 (2012) | |||||||||
| Serine/threonine-protein kinase Aurora-A (Homo sapiens (Human)) | BDBM87055 (Bisanilinopyrimidine inhibitor, 9 | Bisanilinopyri...) | DrugBank GoogleScholar KEGG PDB | PC cid PC sid PDB | n/a | -25.9 | -67 | n/a | 7.40 | 25 | |
Moffitt Cancer Center and Research Institute | ACS Chem Biol 7: 698-706 (2012) | |||||||||
| Serine/threonine-protein kinase Aurora-A (Homo sapiens (Human)) | BDBM87051 (Bisanilinopyrimidine inhibitor, 5 | Bisanilinopyri...) | DrugBank GoogleScholar KEGG PDB | PC cid PC sid PDB | n/a | -5.07 | -46 | n/a | 7.40 | 25 | |
Moffitt Cancer Center and Research Institute | ACS Chem Biol 7: 698-706 (2012) | |||||||||
