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PubMed code 22269278

Compile data set for download or QSAR
Found 50 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Ephrin type-A receptor 2


(Homo sapiens (Human))
BDBM50364832
PNG
(CHEMBL1949788)
Show SMILES COc1ccc(cc1\C=C\c1ccc(Cl)cc1)C(=O)NC[C@@H](O)CO |r|
Show InChI InChI=1S/C19H20ClNO4/c1-25-18-9-6-15(19(24)21-11-17(23)12-22)10-14(18)5-2-13-3-7-16(20)8-4-13/h2-10,17,22-23H,11-12H2,1H3,(H,21,24)/b5-2+/t17-/m1/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of EPHA2


Bioorg Med Chem 20: 1442-60 (2012)


Article DOI: 10.1016/j.bmc.2011.12.058
BindingDB Entry DOI: 10.7270/Q2SB466W
More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM50364832
PNG
(CHEMBL1949788)
Show SMILES COc1ccc(cc1\C=C\c1ccc(Cl)cc1)C(=O)NC[C@@H](O)CO |r|
Show InChI InChI=1S/C19H20ClNO4/c1-25-18-9-6-15(19(24)21-11-17(23)12-22)10-14(18)5-2-13-3-7-16(20)8-4-13/h2-10,17,22-23H,11-12H2,1H3,(H,21,24)/b5-2+/t17-/m1/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of RON


Bioorg Med Chem 20: 1442-60 (2012)


Article DOI: 10.1016/j.bmc.2011.12.058
BindingDB Entry DOI: 10.7270/Q2SB466W
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50364832
PNG
(CHEMBL1949788)
Show SMILES COc1ccc(cc1\C=C\c1ccc(Cl)cc1)C(=O)NC[C@@H](O)CO |r|
Show InChI InChI=1S/C19H20ClNO4/c1-25-18-9-6-15(19(24)21-11-17(23)12-22)10-14(18)5-2-13-3-7-16(20)8-4-13/h2-10,17,22-23H,11-12H2,1H3,(H,21,24)/b5-2+/t17-/m1/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of FLT3


Bioorg Med Chem 20: 1442-60 (2012)


Article DOI: 10.1016/j.bmc.2011.12.058
BindingDB Entry DOI: 10.7270/Q2SB466W
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM50364832
PNG
(CHEMBL1949788)
Show SMILES COc1ccc(cc1\C=C\c1ccc(Cl)cc1)C(=O)NC[C@@H](O)CO |r|
Show InChI InChI=1S/C19H20ClNO4/c1-25-18-9-6-15(19(24)21-11-17(23)12-22)10-14(18)5-2-13-3-7-16(20)8-4-13/h2-10,17,22-23H,11-12H2,1H3,(H,21,24)/b5-2+/t17-/m1/s1
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Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of DDR1


Bioorg Med Chem 20: 1442-60 (2012)


Article DOI: 10.1016/j.bmc.2011.12.058
BindingDB Entry DOI: 10.7270/Q2SB466W
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Yes


(Homo sapiens (Human))
BDBM50364833
PNG
(CHEMBL1949789)
Show SMILES COc1ccc(cc1\C=C\c1ccc(Cl)cc1)C(=O)NC[C@H](O)CO |r|
Show InChI InChI=1S/C19H20ClNO4/c1-25-18-9-6-15(19(24)21-11-17(23)12-22)10-14(18)5-2-13-3-7-16(20)8-4-13/h2-10,17,22-23H,11-12H2,1H3,(H,21,24)/b5-2+/t17-/m0/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of YES


Bioorg Med Chem 20: 1442-60 (2012)


Article DOI: 10.1016/j.bmc.2011.12.058
BindingDB Entry DOI: 10.7270/Q2SB466W
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50364833
PNG
(CHEMBL1949789)
Show SMILES COc1ccc(cc1\C=C\c1ccc(Cl)cc1)C(=O)NC[C@H](O)CO |r|
Show InChI InChI=1S/C19H20ClNO4/c1-25-18-9-6-15(19(24)21-11-17(23)12-22)10-14(18)5-2-13-3-7-16(20)8-4-13/h2-10,17,22-23H,11-12H2,1H3,(H,21,24)/b5-2+/t17-/m0/s1
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Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of LCK


Bioorg Med Chem 20: 1442-60 (2012)


Article DOI: 10.1016/j.bmc.2011.12.058
BindingDB Entry DOI: 10.7270/Q2SB466W
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lyn


(Homo sapiens (Human))
BDBM50364833
PNG
(CHEMBL1949789)
Show SMILES COc1ccc(cc1\C=C\c1ccc(Cl)cc1)C(=O)NC[C@H](O)CO |r|
Show InChI InChI=1S/C19H20ClNO4/c1-25-18-9-6-15(19(24)21-11-17(23)12-22)10-14(18)5-2-13-3-7-16(20)8-4-13/h2-10,17,22-23H,11-12H2,1H3,(H,21,24)/b5-2+/t17-/m0/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of Lyn


Bioorg Med Chem 20: 1442-60 (2012)


Article DOI: 10.1016/j.bmc.2011.12.058
BindingDB Entry DOI: 10.7270/Q2SB466W
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))
BDBM50364832
PNG
(CHEMBL1949788)
Show SMILES COc1ccc(cc1\C=C\c1ccc(Cl)cc1)C(=O)NC[C@@H](O)CO |r|
Show InChI InChI=1S/C19H20ClNO4/c1-25-18-9-6-15(19(24)21-11-17(23)12-22)10-14(18)5-2-13-3-7-16(20)8-4-13/h2-10,17,22-23H,11-12H2,1H3,(H,21,24)/b5-2+/t17-/m1/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of ABL


Bioorg Med Chem 20: 1442-60 (2012)


Article DOI: 10.1016/j.bmc.2011.12.058
BindingDB Entry DOI: 10.7270/Q2SB466W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50364833
PNG
(CHEMBL1949789)
Show SMILES COc1ccc(cc1\C=C\c1ccc(Cl)cc1)C(=O)NC[C@H](O)CO |r|
Show InChI InChI=1S/C19H20ClNO4/c1-25-18-9-6-15(19(24)21-11-17(23)12-22)10-14(18)5-2-13-3-7-16(20)8-4-13/h2-10,17,22-23H,11-12H2,1H3,(H,21,24)/b5-2+/t17-/m0/s1
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Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem 20: 1442-60 (2012)


Article DOI: 10.1016/j.bmc.2011.12.058
BindingDB Entry DOI: 10.7270/Q2SB466W
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM50364832
PNG
(CHEMBL1949788)
Show SMILES COc1ccc(cc1\C=C\c1ccc(Cl)cc1)C(=O)NC[C@@H](O)CO |r|
Show InChI InChI=1S/C19H20ClNO4/c1-25-18-9-6-15(19(24)21-11-17(23)12-22)10-14(18)5-2-13-3-7-16(20)8-4-13/h2-10,17,22-23H,11-12H2,1H3,(H,21,24)/b5-2+/t17-/m1/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of CDK2


Bioorg Med Chem 20: 1442-60 (2012)


Article DOI: 10.1016/j.bmc.2011.12.058
BindingDB Entry DOI: 10.7270/Q2SB466W
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (Human))
BDBM50364833
PNG
(CHEMBL1949789)
Show SMILES COc1ccc(cc1\C=C\c1ccc(Cl)cc1)C(=O)NC[C@H](O)CO |r|
Show InChI InChI=1S/C19H20ClNO4/c1-25-18-9-6-15(19(24)21-11-17(23)12-22)10-14(18)5-2-13-3-7-16(20)8-4-13/h2-10,17,22-23H,11-12H2,1H3,(H,21,24)/b5-2+/t17-/m0/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of INSR


Bioorg Med Chem 20: 1442-60 (2012)


Article DOI: 10.1016/j.bmc.2011.12.058
BindingDB Entry DOI: 10.7270/Q2SB466W
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 1


(Homo sapiens (Human))
BDBM50364833
PNG
(CHEMBL1949789)
Show SMILES COc1ccc(cc1\C=C\c1ccc(Cl)cc1)C(=O)NC[C@H](O)CO |r|
Show InChI InChI=1S/C19H20ClNO4/c1-25-18-9-6-15(19(24)21-11-17(23)12-22)10-14(18)5-2-13-3-7-16(20)8-4-13/h2-10,17,22-23H,11-12H2,1H3,(H,21,24)/b5-2+/t17-/m0/s1
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Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of CDK1


Bioorg Med Chem 20: 1442-60 (2012)


Article DOI: 10.1016/j.bmc.2011.12.058
BindingDB Entry DOI: 10.7270/Q2SB466W
More data for this
Ligand-Target Pair
Leukocyte tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50364832
PNG
(CHEMBL1949788)
Show SMILES COc1ccc(cc1\C=C\c1ccc(Cl)cc1)C(=O)NC[C@@H](O)CO |r|
Show InChI InChI=1S/C19H20ClNO4/c1-25-18-9-6-15(19(24)21-11-17(23)12-22)10-14(18)5-2-13-3-7-16(20)8-4-13/h2-10,17,22-23H,11-12H2,1H3,(H,21,24)/b5-2+/t17-/m1/s1
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Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of LTK


Bioorg Med Chem 20: 1442-60 (2012)


Article DOI: 10.1016/j.bmc.2011.12.058
BindingDB Entry DOI: 10.7270/Q2SB466W
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50364833
PNG
(CHEMBL1949789)
Show SMILES COc1ccc(cc1\C=C\c1ccc(Cl)cc1)C(=O)NC[C@H](O)CO |r|
Show InChI InChI=1S/C19H20ClNO4/c1-25-18-9-6-15(19(24)21-11-17(23)12-22)10-14(18)5-2-13-3-7-16(20)8-4-13/h2-10,17,22-23H,11-12H2,1H3,(H,21,24)/b5-2+/t17-/m0/s1
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Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of MET


Bioorg Med Chem 20: 1442-60 (2012)


Article DOI: 10.1016/j.bmc.2011.12.058
BindingDB Entry DOI: 10.7270/Q2SB466W
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Yes


(Homo sapiens (Human))
BDBM50364832
PNG
(CHEMBL1949788)
Show SMILES COc1ccc(cc1\C=C\c1ccc(Cl)cc1)C(=O)NC[C@@H](O)CO |r|
Show InChI InChI=1S/C19H20ClNO4/c1-25-18-9-6-15(19(24)21-11-17(23)12-22)10-14(18)5-2-13-3-7-16(20)8-4-13/h2-10,17,22-23H,11-12H2,1H3,(H,21,24)/b5-2+/t17-/m1/s1
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Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of YES


Bioorg Med Chem 20: 1442-60 (2012)


Article DOI: 10.1016/j.bmc.2011.12.058
BindingDB Entry DOI: 10.7270/Q2SB466W
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50364833
PNG
(CHEMBL1949789)
Show SMILES COc1ccc(cc1\C=C\c1ccc(Cl)cc1)C(=O)NC[C@H](O)CO |r|
Show InChI InChI=1S/C19H20ClNO4/c1-25-18-9-6-15(19(24)21-11-17(23)12-22)10-14(18)5-2-13-3-7-16(20)8-4-13/h2-10,17,22-23H,11-12H2,1H3,(H,21,24)/b5-2+/t17-/m0/s1
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Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of Src


Bioorg Med Chem 20: 1442-60 (2012)


Article DOI: 10.1016/j.bmc.2011.12.058
BindingDB Entry DOI: 10.7270/Q2SB466W
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BRK


(Homo sapiens (Human))
BDBM50364833
PNG
(CHEMBL1949789)
Show SMILES COc1ccc(cc1\C=C\c1ccc(Cl)cc1)C(=O)NC[C@H](O)CO |r|
Show InChI InChI=1S/C19H20ClNO4/c1-25-18-9-6-15(19(24)21-11-17(23)12-22)10-14(18)5-2-13-3-7-16(20)8-4-13/h2-10,17,22-23H,11-12H2,1H3,(H,21,24)/b5-2+/t17-/m0/s1
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Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of BRK


Bioorg Med Chem 20: 1442-60 (2012)


Article DOI: 10.1016/j.bmc.2011.12.058
BindingDB Entry DOI: 10.7270/Q2SB466W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50364832
PNG
(CHEMBL1949788)
Show SMILES COc1ccc(cc1\C=C\c1ccc(Cl)cc1)C(=O)NC[C@@H](O)CO |r|
Show InChI InChI=1S/C19H20ClNO4/c1-25-18-9-6-15(19(24)21-11-17(23)12-22)10-14(18)5-2-13-3-7-16(20)8-4-13/h2-10,17,22-23H,11-12H2,1H3,(H,21,24)/b5-2+/t17-/m1/s1
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Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem 20: 1442-60 (2012)


Article DOI: 10.1016/j.bmc.2011.12.058
BindingDB Entry DOI: 10.7270/Q2SB466W
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50364832
PNG
(CHEMBL1949788)
Show SMILES COc1ccc(cc1\C=C\c1ccc(Cl)cc1)C(=O)NC[C@@H](O)CO |r|
Show InChI InChI=1S/C19H20ClNO4/c1-25-18-9-6-15(19(24)21-11-17(23)12-22)10-14(18)5-2-13-3-7-16(20)8-4-13/h2-10,17,22-23H,11-12H2,1H3,(H,21,24)/b5-2+/t17-/m1/s1
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Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of Src


Bioorg Med Chem 20: 1442-60 (2012)


Article DOI: 10.1016/j.bmc.2011.12.058
BindingDB Entry DOI: 10.7270/Q2SB466W
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lyn


(Homo sapiens (Human))
BDBM50364832
PNG
(CHEMBL1949788)
Show SMILES COc1ccc(cc1\C=C\c1ccc(Cl)cc1)C(=O)NC[C@@H](O)CO |r|
Show InChI InChI=1S/C19H20ClNO4/c1-25-18-9-6-15(19(24)21-11-17(23)12-22)10-14(18)5-2-13-3-7-16(20)8-4-13/h2-10,17,22-23H,11-12H2,1H3,(H,21,24)/b5-2+/t17-/m1/s1
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Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of Lyn


Bioorg Med Chem 20: 1442-60 (2012)


Article DOI: 10.1016/j.bmc.2011.12.058
BindingDB Entry DOI: 10.7270/Q2SB466W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50364834
PNG
(CHEMBL1340723)
Show SMILES COc1ccc(cc1COc1ccc(Cl)c(C)c1)C(C)=O
Show InChI InChI=1S/C17H17ClO3/c1-11-8-15(5-6-16(11)18)21-10-14-9-13(12(2)19)4-7-17(14)20-3/h4-9H,10H2,1-3H3
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Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem 20: 1442-60 (2012)


Article DOI: 10.1016/j.bmc.2011.12.058
BindingDB Entry DOI: 10.7270/Q2SB466W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50364837
PNG
(CHEMBL1952362)
Show SMILES COc1ccc(cc1\C=C\c1ccc(Cl)cc1)C(N)=O
Show InChI InChI=1S/C16H14ClNO2/c1-20-15-9-6-13(16(18)19)10-12(15)5-2-11-3-7-14(17)8-4-11/h2-10H,1H3,(H2,18,19)/b5-2+
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Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem 20: 1442-60 (2012)


Article DOI: 10.1016/j.bmc.2011.12.058
BindingDB Entry DOI: 10.7270/Q2SB466W
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 1


(Homo sapiens (Human))
BDBM50364832
PNG
(CHEMBL1949788)
Show SMILES COc1ccc(cc1\C=C\c1ccc(Cl)cc1)C(=O)NC[C@@H](O)CO |r|
Show InChI InChI=1S/C19H20ClNO4/c1-25-18-9-6-15(19(24)21-11-17(23)12-22)10-14(18)5-2-13-3-7-16(20)8-4-13/h2-10,17,22-23H,11-12H2,1H3,(H,21,24)/b5-2+/t17-/m1/s1
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Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of CDK1


Bioorg Med Chem 20: 1442-60 (2012)


Article DOI: 10.1016/j.bmc.2011.12.058
BindingDB Entry DOI: 10.7270/Q2SB466W
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50364832
PNG
(CHEMBL1949788)
Show SMILES COc1ccc(cc1\C=C\c1ccc(Cl)cc1)C(=O)NC[C@@H](O)CO |r|
Show InChI InChI=1S/C19H20ClNO4/c1-25-18-9-6-15(19(24)21-11-17(23)12-22)10-14(18)5-2-13-3-7-16(20)8-4-13/h2-10,17,22-23H,11-12H2,1H3,(H,21,24)/b5-2+/t17-/m1/s1
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Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of MET


Bioorg Med Chem 20: 1442-60 (2012)


Article DOI: 10.1016/j.bmc.2011.12.058
BindingDB Entry DOI: 10.7270/Q2SB466W
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50364833
PNG
(CHEMBL1949789)
Show SMILES COc1ccc(cc1\C=C\c1ccc(Cl)cc1)C(=O)NC[C@H](O)CO |r|
Show InChI InChI=1S/C19H20ClNO4/c1-25-18-9-6-15(19(24)21-11-17(23)12-22)10-14(18)5-2-13-3-7-16(20)8-4-13/h2-10,17,22-23H,11-12H2,1H3,(H,21,24)/b5-2+/t17-/m0/s1
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Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of FLT3


Bioorg Med Chem 20: 1442-60 (2012)


Article DOI: 10.1016/j.bmc.2011.12.058
BindingDB Entry DOI: 10.7270/Q2SB466W
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM50364832
PNG
(CHEMBL1949788)
Show SMILES COc1ccc(cc1\C=C\c1ccc(Cl)cc1)C(=O)NC[C@@H](O)CO |r|
Show InChI InChI=1S/C19H20ClNO4/c1-25-18-9-6-15(19(24)21-11-17(23)12-22)10-14(18)5-2-13-3-7-16(20)8-4-13/h2-10,17,22-23H,11-12H2,1H3,(H,21,24)/b5-2+/t17-/m1/s1
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Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of AXL


Bioorg Med Chem 20: 1442-60 (2012)


Article DOI: 10.1016/j.bmc.2011.12.058
BindingDB Entry DOI: 10.7270/Q2SB466W
More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM50364833
PNG
(CHEMBL1949789)
Show SMILES COc1ccc(cc1\C=C\c1ccc(Cl)cc1)C(=O)NC[C@H](O)CO |r|
Show InChI InChI=1S/C19H20ClNO4/c1-25-18-9-6-15(19(24)21-11-17(23)12-22)10-14(18)5-2-13-3-7-16(20)8-4-13/h2-10,17,22-23H,11-12H2,1H3,(H,21,24)/b5-2+/t17-/m0/s1
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Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of RON


Bioorg Med Chem 20: 1442-60 (2012)


Article DOI: 10.1016/j.bmc.2011.12.058
BindingDB Entry DOI: 10.7270/Q2SB466W
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50364833
PNG
(CHEMBL1949789)
Show SMILES COc1ccc(cc1\C=C\c1ccc(Cl)cc1)C(=O)NC[C@H](O)CO |r|
Show InChI InChI=1S/C19H20ClNO4/c1-25-18-9-6-15(19(24)21-11-17(23)12-22)10-14(18)5-2-13-3-7-16(20)8-4-13/h2-10,17,22-23H,11-12H2,1H3,(H,21,24)/b5-2+/t17-/m0/s1
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Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of IGF1R


Bioorg Med Chem 20: 1442-60 (2012)


Article DOI: 10.1016/j.bmc.2011.12.058
BindingDB Entry DOI: 10.7270/Q2SB466W
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Fyn


(Homo sapiens (Human))
BDBM50364832
PNG
(CHEMBL1949788)
Show SMILES COc1ccc(cc1\C=C\c1ccc(Cl)cc1)C(=O)NC[C@@H](O)CO |r|
Show InChI InChI=1S/C19H20ClNO4/c1-25-18-9-6-15(19(24)21-11-17(23)12-22)10-14(18)5-2-13-3-7-16(20)8-4-13/h2-10,17,22-23H,11-12H2,1H3,(H,21,24)/b5-2+/t17-/m1/s1
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Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of Fyn


Bioorg Med Chem 20: 1442-60 (2012)


Article DOI: 10.1016/j.bmc.2011.12.058
BindingDB Entry DOI: 10.7270/Q2SB466W
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50364832
PNG
(CHEMBL1949788)
Show SMILES COc1ccc(cc1\C=C\c1ccc(Cl)cc1)C(=O)NC[C@@H](O)CO |r|
Show InChI InChI=1S/C19H20ClNO4/c1-25-18-9-6-15(19(24)21-11-17(23)12-22)10-14(18)5-2-13-3-7-16(20)8-4-13/h2-10,17,22-23H,11-12H2,1H3,(H,21,24)/b5-2+/t17-/m1/s1
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Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of LCK


Bioorg Med Chem 20: 1442-60 (2012)


Article DOI: 10.1016/j.bmc.2011.12.058
BindingDB Entry DOI: 10.7270/Q2SB466W
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM50364833
PNG
(CHEMBL1949789)
Show SMILES COc1ccc(cc1\C=C\c1ccc(Cl)cc1)C(=O)NC[C@H](O)CO |r|
Show InChI InChI=1S/C19H20ClNO4/c1-25-18-9-6-15(19(24)21-11-17(23)12-22)10-14(18)5-2-13-3-7-16(20)8-4-13/h2-10,17,22-23H,11-12H2,1H3,(H,21,24)/b5-2+/t17-/m0/s1
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Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of GSK3-beta


Bioorg Med Chem 20: 1442-60 (2012)


Article DOI: 10.1016/j.bmc.2011.12.058
BindingDB Entry DOI: 10.7270/Q2SB466W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50364836
PNG
(CHEMBL1952358)
Show SMILES COc1ccc(cc1COc1ccc(Cl)cc1)C(N)=O
Show InChI InChI=1S/C15H14ClNO3/c1-19-14-7-2-10(15(17)18)8-11(14)9-20-13-5-3-12(16)4-6-13/h2-8H,9H2,1H3,(H2,17,18)
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Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem 20: 1442-60 (2012)


Article DOI: 10.1016/j.bmc.2011.12.058
BindingDB Entry DOI: 10.7270/Q2SB466W
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM50364833
PNG
(CHEMBL1949789)
Show SMILES COc1ccc(cc1\C=C\c1ccc(Cl)cc1)C(=O)NC[C@H](O)CO |r|
Show InChI InChI=1S/C19H20ClNO4/c1-25-18-9-6-15(19(24)21-11-17(23)12-22)10-14(18)5-2-13-3-7-16(20)8-4-13/h2-10,17,22-23H,11-12H2,1H3,(H,21,24)/b5-2+/t17-/m0/s1
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Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of CDK2


Bioorg Med Chem 20: 1442-60 (2012)


Article DOI: 10.1016/j.bmc.2011.12.058
BindingDB Entry DOI: 10.7270/Q2SB466W
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM50364832
PNG
(CHEMBL1949788)
Show SMILES COc1ccc(cc1\C=C\c1ccc(Cl)cc1)C(=O)NC[C@@H](O)CO |r|
Show InChI InChI=1S/C19H20ClNO4/c1-25-18-9-6-15(19(24)21-11-17(23)12-22)10-14(18)5-2-13-3-7-16(20)8-4-13/h2-10,17,22-23H,11-12H2,1H3,(H,21,24)/b5-2+/t17-/m1/s1
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Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of FGFR2


Bioorg Med Chem 20: 1442-60 (2012)


Article DOI: 10.1016/j.bmc.2011.12.058
BindingDB Entry DOI: 10.7270/Q2SB466W
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM50364833
PNG
(CHEMBL1949789)
Show SMILES COc1ccc(cc1\C=C\c1ccc(Cl)cc1)C(=O)NC[C@H](O)CO |r|
Show InChI InChI=1S/C19H20ClNO4/c1-25-18-9-6-15(19(24)21-11-17(23)12-22)10-14(18)5-2-13-3-7-16(20)8-4-13/h2-10,17,22-23H,11-12H2,1H3,(H,21,24)/b5-2+/t17-/m0/s1
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Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of FGFR2


Bioorg Med Chem 20: 1442-60 (2012)


Article DOI: 10.1016/j.bmc.2011.12.058
BindingDB Entry DOI: 10.7270/Q2SB466W
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50364832
PNG
(CHEMBL1949788)
Show SMILES COc1ccc(cc1\C=C\c1ccc(Cl)cc1)C(=O)NC[C@@H](O)CO |r|
Show InChI InChI=1S/C19H20ClNO4/c1-25-18-9-6-15(19(24)21-11-17(23)12-22)10-14(18)5-2-13-3-7-16(20)8-4-13/h2-10,17,22-23H,11-12H2,1H3,(H,21,24)/b5-2+/t17-/m1/s1
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Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of EGFR


Bioorg Med Chem 20: 1442-60 (2012)


Article DOI: 10.1016/j.bmc.2011.12.058
BindingDB Entry DOI: 10.7270/Q2SB466W
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))
BDBM50364833
PNG
(CHEMBL1949789)
Show SMILES COc1ccc(cc1\C=C\c1ccc(Cl)cc1)C(=O)NC[C@H](O)CO |r|
Show InChI InChI=1S/C19H20ClNO4/c1-25-18-9-6-15(19(24)21-11-17(23)12-22)10-14(18)5-2-13-3-7-16(20)8-4-13/h2-10,17,22-23H,11-12H2,1H3,(H,21,24)/b5-2+/t17-/m0/s1
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Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of DDR1


Bioorg Med Chem 20: 1442-60 (2012)


Article DOI: 10.1016/j.bmc.2011.12.058
BindingDB Entry DOI: 10.7270/Q2SB466W
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Fyn


(Homo sapiens (Human))
BDBM50364833
PNG
(CHEMBL1949789)
Show SMILES COc1ccc(cc1\C=C\c1ccc(Cl)cc1)C(=O)NC[C@H](O)CO |r|
Show InChI InChI=1S/C19H20ClNO4/c1-25-18-9-6-15(19(24)21-11-17(23)12-22)10-14(18)5-2-13-3-7-16(20)8-4-13/h2-10,17,22-23H,11-12H2,1H3,(H,21,24)/b5-2+/t17-/m0/s1
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Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of Fyn


Bioorg Med Chem 20: 1442-60 (2012)


Article DOI: 10.1016/j.bmc.2011.12.058
BindingDB Entry DOI: 10.7270/Q2SB466W
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))
BDBM50364833
PNG
(CHEMBL1949789)
Show SMILES COc1ccc(cc1\C=C\c1ccc(Cl)cc1)C(=O)NC[C@H](O)CO |r|
Show InChI InChI=1S/C19H20ClNO4/c1-25-18-9-6-15(19(24)21-11-17(23)12-22)10-14(18)5-2-13-3-7-16(20)8-4-13/h2-10,17,22-23H,11-12H2,1H3,(H,21,24)/b5-2+/t17-/m0/s1
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Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of ABL


Bioorg Med Chem 20: 1442-60 (2012)


Article DOI: 10.1016/j.bmc.2011.12.058
BindingDB Entry DOI: 10.7270/Q2SB466W
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BRK


(Homo sapiens (Human))
BDBM50364832
PNG
(CHEMBL1949788)
Show SMILES COc1ccc(cc1\C=C\c1ccc(Cl)cc1)C(=O)NC[C@@H](O)CO |r|
Show InChI InChI=1S/C19H20ClNO4/c1-25-18-9-6-15(19(24)21-11-17(23)12-22)10-14(18)5-2-13-3-7-16(20)8-4-13/h2-10,17,22-23H,11-12H2,1H3,(H,21,24)/b5-2+/t17-/m1/s1
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Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of BRK


Bioorg Med Chem 20: 1442-60 (2012)


Article DOI: 10.1016/j.bmc.2011.12.058
BindingDB Entry DOI: 10.7270/Q2SB466W
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM50364832
PNG
(CHEMBL1949788)
Show SMILES COc1ccc(cc1\C=C\c1ccc(Cl)cc1)C(=O)NC[C@@H](O)CO |r|
Show InChI InChI=1S/C19H20ClNO4/c1-25-18-9-6-15(19(24)21-11-17(23)12-22)10-14(18)5-2-13-3-7-16(20)8-4-13/h2-10,17,22-23H,11-12H2,1H3,(H,21,24)/b5-2+/t17-/m1/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of GSK3-beta


Bioorg Med Chem 20: 1442-60 (2012)


Article DOI: 10.1016/j.bmc.2011.12.058
BindingDB Entry DOI: 10.7270/Q2SB466W
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM50364833
PNG
(CHEMBL1949789)
Show SMILES COc1ccc(cc1\C=C\c1ccc(Cl)cc1)C(=O)NC[C@H](O)CO |r|
Show InChI InChI=1S/C19H20ClNO4/c1-25-18-9-6-15(19(24)21-11-17(23)12-22)10-14(18)5-2-13-3-7-16(20)8-4-13/h2-10,17,22-23H,11-12H2,1H3,(H,21,24)/b5-2+/t17-/m0/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of AXL


Bioorg Med Chem 20: 1442-60 (2012)


Article DOI: 10.1016/j.bmc.2011.12.058
BindingDB Entry DOI: 10.7270/Q2SB466W
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (Human))
BDBM50364832
PNG
(CHEMBL1949788)
Show SMILES COc1ccc(cc1\C=C\c1ccc(Cl)cc1)C(=O)NC[C@@H](O)CO |r|
Show InChI InChI=1S/C19H20ClNO4/c1-25-18-9-6-15(19(24)21-11-17(23)12-22)10-14(18)5-2-13-3-7-16(20)8-4-13/h2-10,17,22-23H,11-12H2,1H3,(H,21,24)/b5-2+/t17-/m1/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of INSR


Bioorg Med Chem 20: 1442-60 (2012)


Article DOI: 10.1016/j.bmc.2011.12.058
BindingDB Entry DOI: 10.7270/Q2SB466W
More data for this
Ligand-Target Pair
Leukocyte tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50364833
PNG
(CHEMBL1949789)
Show SMILES COc1ccc(cc1\C=C\c1ccc(Cl)cc1)C(=O)NC[C@H](O)CO |r|
Show InChI InChI=1S/C19H20ClNO4/c1-25-18-9-6-15(19(24)21-11-17(23)12-22)10-14(18)5-2-13-3-7-16(20)8-4-13/h2-10,17,22-23H,11-12H2,1H3,(H,21,24)/b5-2+/t17-/m0/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of LTK


Bioorg Med Chem 20: 1442-60 (2012)


Article DOI: 10.1016/j.bmc.2011.12.058
BindingDB Entry DOI: 10.7270/Q2SB466W
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50364833
PNG
(CHEMBL1949789)
Show SMILES COc1ccc(cc1\C=C\c1ccc(Cl)cc1)C(=O)NC[C@H](O)CO |r|
Show InChI InChI=1S/C19H20ClNO4/c1-25-18-9-6-15(19(24)21-11-17(23)12-22)10-14(18)5-2-13-3-7-16(20)8-4-13/h2-10,17,22-23H,11-12H2,1H3,(H,21,24)/b5-2+/t17-/m0/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of EGFR


Bioorg Med Chem 20: 1442-60 (2012)


Article DOI: 10.1016/j.bmc.2011.12.058
BindingDB Entry DOI: 10.7270/Q2SB466W
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50364832
PNG
(CHEMBL1949788)
Show SMILES COc1ccc(cc1\C=C\c1ccc(Cl)cc1)C(=O)NC[C@@H](O)CO |r|
Show InChI InChI=1S/C19H20ClNO4/c1-25-18-9-6-15(19(24)21-11-17(23)12-22)10-14(18)5-2-13-3-7-16(20)8-4-13/h2-10,17,22-23H,11-12H2,1H3,(H,21,24)/b5-2+/t17-/m1/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of IGF1R


Bioorg Med Chem 20: 1442-60 (2012)


Article DOI: 10.1016/j.bmc.2011.12.058
BindingDB Entry DOI: 10.7270/Q2SB466W
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))
BDBM50364832
PNG
(CHEMBL1949788)
Show SMILES COc1ccc(cc1\C=C\c1ccc(Cl)cc1)C(=O)NC[C@@H](O)CO |r|
Show InChI InChI=1S/C19H20ClNO4/c1-25-18-9-6-15(19(24)21-11-17(23)12-22)10-14(18)5-2-13-3-7-16(20)8-4-13/h2-10,17,22-23H,11-12H2,1H3,(H,21,24)/b5-2+/t17-/m1/s1
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Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of FAK


Bioorg Med Chem 20: 1442-60 (2012)


Article DOI: 10.1016/j.bmc.2011.12.058
BindingDB Entry DOI: 10.7270/Q2SB466W
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))
BDBM50364833
PNG
(CHEMBL1949789)
Show SMILES COc1ccc(cc1\C=C\c1ccc(Cl)cc1)C(=O)NC[C@H](O)CO |r|
Show InChI InChI=1S/C19H20ClNO4/c1-25-18-9-6-15(19(24)21-11-17(23)12-22)10-14(18)5-2-13-3-7-16(20)8-4-13/h2-10,17,22-23H,11-12H2,1H3,(H,21,24)/b5-2+/t17-/m0/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of FAK


Bioorg Med Chem 20: 1442-60 (2012)


Article DOI: 10.1016/j.bmc.2011.12.058
BindingDB Entry DOI: 10.7270/Q2SB466W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50364835
PNG
(CHEMBL1952357)
Show SMILES COc1ccc(cc1COc1ccc(Cl)c(C)c1)C(N)=O
Show InChI InChI=1S/C16H16ClNO3/c1-10-7-13(4-5-14(10)17)21-9-12-8-11(16(18)19)3-6-15(12)20-2/h3-8H,9H2,1-2H3,(H2,18,19)
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Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem 20: 1442-60 (2012)


Article DOI: 10.1016/j.bmc.2011.12.058
BindingDB Entry DOI: 10.7270/Q2SB466W
More data for this
Ligand-Target Pair
Ephrin type-A receptor 2


(Homo sapiens (Human))
BDBM50364833
PNG
(CHEMBL1949789)
Show SMILES COc1ccc(cc1\C=C\c1ccc(Cl)cc1)C(=O)NC[C@H](O)CO |r|
Show InChI InChI=1S/C19H20ClNO4/c1-25-18-9-6-15(19(24)21-11-17(23)12-22)10-14(18)5-2-13-3-7-16(20)8-4-13/h2-10,17,22-23H,11-12H2,1H3,(H,21,24)/b5-2+/t17-/m0/s1
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Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of EPHA2


Bioorg Med Chem 20: 1442-60 (2012)


Article DOI: 10.1016/j.bmc.2011.12.058
BindingDB Entry DOI: 10.7270/Q2SB466W
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%