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PubMed code 22285569

Compile data set for download or QSAR
Found 107 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50110025
PNG
(CHEMBL158405 | N-(BENZYLSULFONYL)-D-SERYL-N-{4-[AM...)
Show SMILES C[C@H](NC(=O)[C@@H](CO)NS(=O)(=O)Cc1ccccc1)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C21H27N5O5S/c1-14(20(28)24-11-15-7-9-17(10-8-15)19(22)23)25-21(29)18(12-27)26-32(30,31)13-16-5-3-2-4-6-16/h2-10,14,18,26-27H,11-13H2,1H3,(H3,22,23)(H,24,28)(H,25,29)/t14-,18+/m0/s1
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 7.70n/an/an/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA using pyroGlu-Gly-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by spectrop...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50138662
PNG
(6-Carbamimidoyl-naphthalene-2-carboxylic acid (4-a...)
Show SMILES NCc1ccc(NC(=O)c2ccc3cc(ccc3c2)C(N)=N)cc1
Show InChI InChI=1S/C19H18N4O/c20-11-12-1-7-17(8-2-12)23-19(24)16-6-4-13-9-15(18(21)22)5-3-14(13)10-16/h1-10H,11,20H2,(H3,21,22)(H,23,24)
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 40n/an/an/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA using pyroGlu-Gly-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by spectrop...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Prothrombin


(Homo sapiens (Human))		BDBM50110025
PNG
(CHEMBL158405 | N-(BENZYLSULFONYL)-D-SERYL-N-{4-[AM...)
Show SMILES C[C@H](NC(=O)[C@@H](CO)NS(=O)(=O)Cc1ccccc1)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C21H27N5O5S/c1-14(20(28)24-11-15-7-9-17(10-8-15)19(22)23)25-21(29)18(12-27)26-32(30,31)13-16-5-3-2-4-6-16/h2-10,14,18,26-27H,11-13H2,1H3,(H3,22,23)(H,24,28)(H,25,29)/t14-,18+/m0/s1
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 100n/an/an/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human plasma thrombin using pyroGlu-Pro-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50138678
PNG
(6-Carbamimidoyl-naphthalene-2-carboxylic acid (3,5...)
Show SMILES COc1cc(NC(=O)c2ccc3cc(ccc3c2)C(N)=N)cc(OC)c1
Show InChI InChI=1S/C20H19N3O3/c1-25-17-9-16(10-18(11-17)26-2)23-20(24)15-6-4-12-7-14(19(21)22)5-3-13(12)8-15/h3-11H,1-2H3,(H3,21,22)(H,23,24)
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 139n/an/an/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA using pyroGlu-Gly-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by spectrop...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (Human))		BDBM23891
PNG
(3-amidinophenylalanine deriv., 35 | CHEMBL107955 |...)
Show SMILES CCOC(=O)N1CCN(CC1)C(=O)[C@H](Cc1cccc(c1)C(N)=N)NS(=O)(=O)c1c(cc(cc1C(C)C)C(C)C)C(C)C |r|
Show InChI InChI=1S/C32H47N5O5S/c1-8-42-32(39)37-14-12-36(13-15-37)31(38)28(17-23-10-9-11-24(16-23)30(33)34)35-43(40,41)29-26(21(4)5)18-25(20(2)3)19-27(29)22(6)7/h9-11,16,18-22,28,35H,8,12-15,17H2,1-7H3,(H3,33,34)/t28-/m0/s1
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 390n/an/an/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human plasma plasmin using pyroGlu-Pro-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins ...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM23891
PNG
(3-amidinophenylalanine deriv., 35 | CHEMBL107955 |...)
Show SMILES CCOC(=O)N1CCN(CC1)C(=O)[C@H](Cc1cccc(c1)C(N)=N)NS(=O)(=O)c1c(cc(cc1C(C)C)C(C)C)C(C)C |r|
Show InChI InChI=1S/C32H47N5O5S/c1-8-42-32(39)37-14-12-36(13-15-37)31(38)28(17-23-10-9-11-24(16-23)30(33)34)35-43(40,41)29-26(21(4)5)18-25(20(2)3)19-27(29)22(6)7/h9-11,16,18-22,28,35H,8,12-15,17H2,1-7H3,(H3,33,34)/t28-/m0/s1
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 410n/an/an/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA using pyroGlu-Gly-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by spectrop...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))		BDBM23891
PNG
(3-amidinophenylalanine deriv., 35 | CHEMBL107955 |...)
Show SMILES CCOC(=O)N1CCN(CC1)C(=O)[C@H](Cc1cccc(c1)C(N)=N)NS(=O)(=O)c1c(cc(cc1C(C)C)C(C)C)C(C)C |r|
Show InChI InChI=1S/C32H47N5O5S/c1-8-42-32(39)37-14-12-36(13-15-37)31(38)28(17-23-10-9-11-24(16-23)30(33)34)35-43(40,41)29-26(21(4)5)18-25(20(2)3)19-27(29)22(6)7/h9-11,16,18-22,28,35H,8,12-15,17H2,1-7H3,(H3,33,34)/t28-/m0/s1
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 490n/an/an/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human plasma thrombin using pyroGlu-Pro-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (Human))		BDBM50110025
PNG
(CHEMBL158405 | N-(BENZYLSULFONYL)-D-SERYL-N-{4-[AM...)
Show SMILES C[C@H](NC(=O)[C@@H](CO)NS(=O)(=O)Cc1ccccc1)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C21H27N5O5S/c1-14(20(28)24-11-15-7-9-17(10-8-15)19(22)23)25-21(29)18(12-27)26-32(30,31)13-16-5-3-2-4-6-16/h2-10,14,18,26-27H,11-13H2,1H3,(H3,22,23)(H,24,28)(H,25,29)/t14-,18+/m0/s1
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 540n/an/an/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human plasma plasmin using pyroGlu-Pro-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins ...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50138670
PNG
(6-Carbamimidoyl-naphthalene-2-carboxylic acid phen...)
Show SMILES NC(=N)c1ccc2cc(ccc2c1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C18H15N3O/c19-17(20)14-8-6-13-11-15(9-7-12(13)10-14)18(22)21-16-4-2-1-3-5-16/h1-11H,(H3,19,20)(H,21,22)
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 631n/an/an/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA using pyroGlu-Gly-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by spectrop...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50138670
PNG
(6-Carbamimidoyl-naphthalene-2-carboxylic acid phen...)
Show SMILES NC(=N)c1ccc2cc(ccc2c1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C18H15N3O/c19-17(20)14-8-6-13-11-15(9-7-12(13)10-14)18(22)21-16-4-2-1-3-5-16/h1-11H,(H3,19,20)(H,21,22)
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 1.90E+3n/an/an/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Competitive inhibition of human uPA using pyroGlu-Gly-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Plasminogen


(Homo sapiens (Human))		BDBM50138670
PNG
(6-Carbamimidoyl-naphthalene-2-carboxylic acid phen...)
Show SMILES NC(=N)c1ccc2cc(ccc2c1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C18H15N3O/c19-17(20)14-8-6-13-11-15(9-7-12(13)10-14)18(22)21-16-4-2-1-3-5-16/h1-11H,(H3,19,20)(H,21,22)
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 1.95E+3n/an/an/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human plasma plasmin using pyroGlu-Pro-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins ...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Tissue-type plasminogen activator


(Homo sapiens (Human))		BDBM23891
PNG
(3-amidinophenylalanine deriv., 35 | CHEMBL107955 |...)
Show SMILES CCOC(=O)N1CCN(CC1)C(=O)[C@H](Cc1cccc(c1)C(N)=N)NS(=O)(=O)c1c(cc(cc1C(C)C)C(C)C)C(C)C |r|
Show InChI InChI=1S/C32H47N5O5S/c1-8-42-32(39)37-14-12-36(13-15-37)31(38)28(17-23-10-9-11-24(16-23)30(33)34)35-43(40,41)29-26(21(4)5)18-25(20(2)3)19-27(29)22(6)7/h9-11,16,18-22,28,35H,8,12-15,17H2,1-7H3,(H3,33,34)/t28-/m0/s1
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 4.90E+3n/an/an/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of recombinant tPA using H-D-Ile-Pro-Arg-pNA.2HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by sp...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))		BDBM50138670
PNG
(6-Carbamimidoyl-naphthalene-2-carboxylic acid phen...)
Show SMILES NC(=N)c1ccc2cc(ccc2c1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C18H15N3O/c19-17(20)14-8-6-13-11-15(9-7-12(13)10-14)18(22)21-16-4-2-1-3-5-16/h1-11H,(H3,19,20)(H,21,22)
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 5.64E+3n/an/an/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human plasma thrombin using pyroGlu-Pro-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Tissue-type plasminogen activator


(Homo sapiens (Human))		BDBM50110025
PNG
(CHEMBL158405 | N-(BENZYLSULFONYL)-D-SERYL-N-{4-[AM...)
Show SMILES C[C@H](NC(=O)[C@@H](CO)NS(=O)(=O)Cc1ccccc1)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C21H27N5O5S/c1-14(20(28)24-11-15-7-9-17(10-8-15)19(22)23)25-21(29)18(12-27)26-32(30,31)13-16-5-3-2-4-6-16/h2-10,14,18,26-27H,11-13H2,1H3,(H3,22,23)(H,24,28)(H,25,29)/t14-,18+/m0/s1
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 7.40E+3n/an/an/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of recombinant tPA using H-D-Ile-Pro-Arg-pNA.2HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by sp...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (Human))		BDBM50138662
PNG
(6-Carbamimidoyl-naphthalene-2-carboxylic acid (4-a...)
Show SMILES NCc1ccc(NC(=O)c2ccc3cc(ccc3c2)C(N)=N)cc1
Show InChI InChI=1S/C19H18N4O/c20-11-12-1-7-17(8-2-12)23-19(24)16-6-4-13-9-15(18(21)22)5-3-14(13)10-16/h1-10H,11,20H2,(H3,21,22)(H,23,24)
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 1.60E+4n/an/an/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human plasma plasmin using pyroGlu-Pro-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins ...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Tissue-type plasminogen activator


(Homo sapiens (Human))		BDBM50138670
PNG
(6-Carbamimidoyl-naphthalene-2-carboxylic acid phen...)
Show SMILES NC(=N)c1ccc2cc(ccc2c1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C18H15N3O/c19-17(20)14-8-6-13-11-15(9-7-12(13)10-14)18(22)21-16-4-2-1-3-5-16/h1-11H,(H3,19,20)(H,21,22)
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 3.18E+4n/an/an/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of recombinant tPA using H-D-Ile-Pro-Arg-pNA.2HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by sp...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Tissue-type plasminogen activator


(Homo sapiens (Human))		BDBM50138662
PNG
(6-Carbamimidoyl-naphthalene-2-carboxylic acid (4-a...)
Show SMILES NCc1ccc(NC(=O)c2ccc3cc(ccc3c2)C(N)=N)cc1
Show InChI InChI=1S/C19H18N4O/c20-11-12-1-7-17(8-2-12)23-19(24)16-6-4-13-9-15(18(21)22)5-3-14(13)10-16/h1-10H,11,20H2,(H3,21,22)(H,23,24)
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 5.84E+4n/an/an/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of recombinant tPA using H-D-Ile-Pro-Arg-pNA.2HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by sp...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))		BDBM50138662
PNG
(6-Carbamimidoyl-naphthalene-2-carboxylic acid (4-a...)
Show SMILES NCc1ccc(NC(=O)c2ccc3cc(ccc3c2)C(N)=N)cc1
Show InChI InChI=1S/C19H18N4O/c20-11-12-1-7-17(8-2-12)23-19(24)16-6-4-13-9-15(18(21)22)5-3-14(13)10-16/h1-10H,11,20H2,(H3,21,22)(H,23,24)
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>1.00E+5n/an/an/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human plasma thrombin using pyroGlu-Pro-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50363655
PNG
(CHEMBL1945236)
Show SMILES NC(=N)c1ccc(\C=C2\N=C(OC2=O)c2ccccc2)cc1 |c:9|
Show InChI InChI=1S/C17H13N3O2/c18-15(19)12-8-6-11(7-9-12)10-14-17(21)22-16(20-14)13-4-2-1-3-5-13/h1-10H,(H3,18,19)/b14-10+
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n/an/a 200n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA using pyroGlu-Gly-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by spectrop...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50138662
PNG
(6-Carbamimidoyl-naphthalene-2-carboxylic acid (4-a...)
Show SMILES NCc1ccc(NC(=O)c2ccc3cc(ccc3c2)C(N)=N)cc1
Show InChI InChI=1S/C19H18N4O/c20-11-12-1-7-17(8-2-12)23-19(24)16-6-4-13-9-15(18(21)22)5-3-14(13)10-16/h1-10H,11,20H2,(H3,21,22)(H,23,24)
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n/an/a 1.20E+3n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA using pyroGlu-Gly-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by spectrop...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50363663
PNG
(CHEMBL1945767)
Show SMILES COc1ccc2cc(ccc2c1)C(=O)Nc1ccc(cc1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C25H18F3NO2/c1-31-23-12-9-18-13-20(6-5-19(18)15-23)24(30)29-22-10-7-16(8-11-22)17-3-2-4-21(14-17)25(26,27)28/h2-15H,1H3,(H,29,30)
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n/an/a 2.10E+3n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Non-competitive inhibition of human uPA using pyroGlu-Gly-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 ...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50363658
PNG
(CHEMBL1945757)
Show SMILES NC(=O)c1ccc2cc(ccc2c1)C(=O)Nc1ccc(cc1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C25H17F3N2O2/c26-25(27,28)21-3-1-2-16(14-21)15-8-10-22(11-9-15)30-24(32)20-7-5-17-12-19(23(29)31)6-4-18(17)13-20/h1-14H,(H2,29,31)(H,30,32)
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n/an/a 2.40E+3n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Non-competitive inhibition of human uPA using pyroGlu-Gly-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 ...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50363662
PNG
(CHEMBL1945766)
Show SMILES COc1ccc2cc(ccc2c1)C(=O)Nc1ccc(cc1)-c1cccc(c1)[N+]([O-])=O
Show InChI InChI=1S/C24H18N2O4/c1-30-23-12-9-18-13-20(6-5-19(18)15-23)24(27)25-21-10-7-16(8-11-21)17-3-2-4-22(14-17)26(28)29/h2-15H,1H3,(H,25,27)
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n/an/a 2.60E+3n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA using pyroGlu-Gly-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by spectrop...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50138678
PNG
(6-Carbamimidoyl-naphthalene-2-carboxylic acid (3,5...)
Show SMILES COc1cc(NC(=O)c2ccc3cc(ccc3c2)C(N)=N)cc(OC)c1
Show InChI InChI=1S/C20H19N3O3/c1-25-17-9-16(10-18(11-17)26-2)23-20(24)15-6-4-12-7-14(19(21)22)5-3-13(12)8-15/h3-11H,1-2H3,(H3,21,22)(H,23,24)
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n/an/a 2.60E+3n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA using pyroGlu-Gly-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by spectrop...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50363664
PNG
(CHEMBL1945918)
Show SMILES COC(=O)c1cccc(c1)-c1ccc(NS(=O)(=O)c2ccc3cc(OC)ccc3c2)cc1
Show InChI InChI=1S/C25H21NO5S/c1-30-23-12-8-20-16-24(13-9-19(20)15-23)32(28,29)26-22-10-6-17(7-11-22)18-4-3-5-21(14-18)25(27)31-2/h3-16,26H,1-2H3
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n/an/a 2.80E+3n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Non-competitive inhibition of human uPA using pyroGlu-Gly-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 ...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50363657
PNG
(CHEMBL1945756)
Show SMILES COc1cccc(c1)-c1ccc(NC(=O)c2ccc3cc(ccc3c2)C(N)=O)cc1
Show InChI InChI=1S/C25H20N2O3/c1-30-23-4-2-3-17(15-23)16-9-11-22(12-10-16)27-25(29)21-8-6-18-13-20(24(26)28)7-5-19(18)14-21/h2-15H,1H3,(H2,26,28)(H,27,29)
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n/an/a 2.90E+3n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA using pyroGlu-Gly-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by spectrop...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Tissue-type plasminogen activator


(Homo sapiens (Human))		BDBM50363658
PNG
(CHEMBL1945757)
Show SMILES NC(=O)c1ccc2cc(ccc2c1)C(=O)Nc1ccc(cc1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C25H17F3N2O2/c26-25(27,28)21-3-1-2-16(14-21)15-8-10-22(11-9-15)30-24(32)20-7-5-17-12-19(23(29)31)6-4-18(17)13-20/h1-14H,(H2,29,31)(H,30,32)
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n/an/a 3.40E+3n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of recombinant tPA using H-D-Ile-Pro-Arg-pNA.2HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by sp...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50363656
PNG
(CHEMBL1945669)
Show SMILES COC(=O)c1cccc(c1)-c1ccc(NC(=O)c2ccc3cc(ccc3c2)C(N)=O)cc1
Show InChI InChI=1S/C26H20N2O4/c1-32-26(31)22-4-2-3-17(15-22)16-9-11-23(12-10-16)28-25(30)21-8-6-18-13-20(24(27)29)7-5-19(18)14-21/h2-15H,1H3,(H2,27,29)(H,28,30)
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n/an/a 3.60E+3n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA using pyroGlu-Gly-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by spectrop...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50363660
PNG
(CHEMBL1945764)
Show SMILES COC(=O)c1cccc(c1)-c1ccc(NC(=O)c2ccc3cc(OC)ccc3c2)cc1
Show InChI InChI=1S/C26H21NO4/c1-30-24-13-10-19-14-21(7-6-20(19)16-24)25(28)27-23-11-8-17(9-12-23)18-4-3-5-22(15-18)26(29)31-2/h3-16H,1-2H3,(H,27,28)
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n/an/a 4.00E+3n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA using pyroGlu-Gly-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by spectrop...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50363661
PNG
(CHEMBL1945765)
Show SMILES COc1cccc(c1)-c1ccc(NC(=O)c2ccc3cc(OC)ccc3c2)cc1
Show InChI InChI=1S/C25H21NO3/c1-28-23-5-3-4-18(15-23)17-8-11-22(12-9-17)26-25(27)21-7-6-20-16-24(29-2)13-10-19(20)14-21/h3-16H,1-2H3,(H,26,27)
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n/an/a 4.00E+3n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA using pyroGlu-Gly-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by spectrop...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (Human))		BDBM50363660
PNG
(CHEMBL1945764)
Show SMILES COC(=O)c1cccc(c1)-c1ccc(NC(=O)c2ccc3cc(OC)ccc3c2)cc1
Show InChI InChI=1S/C26H21NO4/c1-30-24-13-10-19-14-21(7-6-20(19)16-24)25(28)27-23-11-8-17(9-12-23)18-4-3-5-22(15-18)26(29)31-2/h3-16H,1-2H3,(H,27,28)
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n/an/a 4.00E+3n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human plasma plasmin using pyroGlu-Pro-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins ...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50363665
PNG
(CHEMBL1944651)
Show SMILES COc1ccc2cc(ccc2c1)S(=O)(=O)Nc1ccc(cc1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H18F3NO3S/c1-31-22-11-7-19-15-23(12-8-18(19)14-22)32(29,30)28-21-9-5-16(6-10-21)17-3-2-4-20(13-17)24(25,26)27/h2-15,28H,1H3
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n/an/a 4.10E+3n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA using pyroGlu-Gly-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by spectrop...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Tissue-type plasminogen activator


(Homo sapiens (Human))		BDBM50363663
PNG
(CHEMBL1945767)
Show SMILES COc1ccc2cc(ccc2c1)C(=O)Nc1ccc(cc1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C25H18F3NO2/c1-31-23-12-9-18-13-20(6-5-19(18)15-23)24(30)29-22-10-7-16(8-11-22)17-3-2-4-21(14-17)25(26,27)28/h2-15H,1H3,(H,29,30)
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n/an/a 5.30E+3n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of recombinant tPA using H-D-Ile-Pro-Arg-pNA.2HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by sp...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Tissue-type plasminogen activator


(Homo sapiens (Human))		BDBM50363657
PNG
(CHEMBL1945756)
Show SMILES COc1cccc(c1)-c1ccc(NC(=O)c2ccc3cc(ccc3c2)C(N)=O)cc1
Show InChI InChI=1S/C25H20N2O3/c1-30-23-4-2-3-17(15-23)16-9-11-22(12-10-16)27-25(29)21-8-6-18-13-20(24(26)28)7-5-19(18)14-21/h2-15H,1H3,(H2,26,28)(H,27,29)
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n/an/a 5.70E+3n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of recombinant tPA using H-D-Ile-Pro-Arg-pNA.2HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by sp...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (Human))		BDBM50363658
PNG
(CHEMBL1945757)
Show SMILES NC(=O)c1ccc2cc(ccc2c1)C(=O)Nc1ccc(cc1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C25H17F3N2O2/c26-25(27,28)21-3-1-2-16(14-21)15-8-10-22(11-9-15)30-24(32)20-7-5-17-12-19(23(29)31)6-4-18(17)13-20/h1-14H,(H2,29,31)(H,30,32)
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n/an/a 6.30E+3n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human plasma plasmin using pyroGlu-Pro-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins ...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50363659
PNG
(CHEMBL1945759)
Show SMILES COc1ccc(cc1)-c1ccc(NC(=O)c2ccc3cc(ccc3c2)C(N)=O)cc1OC
Show InChI InChI=1S/C26H22N2O4/c1-31-22-10-7-16(8-11-22)23-12-9-21(15-24(23)32-2)28-26(30)20-6-4-17-13-19(25(27)29)5-3-18(17)14-20/h3-15H,1-2H3,(H2,27,29)(H,28,30)
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n/an/a 6.40E+3n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA using pyroGlu-Gly-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by spectrop...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (Human))		BDBM50363663
PNG
(CHEMBL1945767)
Show SMILES COc1ccc2cc(ccc2c1)C(=O)Nc1ccc(cc1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C25H18F3NO2/c1-31-23-12-9-18-13-20(6-5-19(18)15-23)24(30)29-22-10-7-16(8-11-22)17-3-2-4-21(14-17)25(26,27)28/h2-15H,1H3,(H,29,30)
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n/an/a 6.50E+3n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human plasma plasmin using pyroGlu-Pro-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins ...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50363697
PNG
(CHEMBL1945923)
Show SMILES COc1ccc2cc(ccc2c1)S(=O)(=O)Nc1ccc(cc1)-c1cccc(c1)[N+]([O-])=O
Show InChI InChI=1S/C23H18N2O5S/c1-30-22-11-7-19-15-23(12-8-18(19)14-22)31(28,29)24-20-9-5-16(6-10-20)17-3-2-4-21(13-17)25(26)27/h2-15,24H,1H3
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n/an/a 6.90E+3n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA using pyroGlu-Gly-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by spectrop...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50363686
PNG
(CHEMBL1945771)
Show SMILES COC(=O)c1cccc(c1)-c1ccc(NC(=O)c2ccc3cc(Cl)ccc3c2)cc1
Show InChI InChI=1S/C25H18ClNO3/c1-30-25(29)21-4-2-3-17(14-21)16-8-11-23(12-9-16)27-24(28)20-6-5-19-15-22(26)10-7-18(19)13-20/h2-15H,1H3,(H,27,28)
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n/an/a 7.00E+3n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA using pyroGlu-Gly-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by spectrop...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50363701
PNG
(CHEMBL1945927)
Show SMILES COc1ccc2cc(ccc2c1)S(=O)(=O)Nc1ccc(cc1)-c1ccc(OC)c(OC)c1
Show InChI InChI=1S/C25H23NO5S/c1-29-22-11-6-19-15-23(12-7-18(19)14-22)32(27,28)26-21-9-4-17(5-10-21)20-8-13-24(30-2)25(16-20)31-3/h4-16,26H,1-3H3
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n/an/a 8.00E+3n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA using pyroGlu-Gly-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by spectrop...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50363702
PNG
(CHEMBL1945928)
Show SMILES COc1ccc(cc1)-c1ccc(NS(=O)(=O)c2ccc3cc(OC)ccc3c2)cc1OC
Show InChI InChI=1S/C25H23NO5S/c1-29-21-9-4-17(5-10-21)24-13-8-20(16-25(24)31-3)26-32(27,28)23-12-7-18-14-22(30-2)11-6-19(18)15-23/h4-16,26H,1-3H3
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n/an/a 8.00E+3n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA using pyroGlu-Gly-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by spectrop...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50363678
PNG
(CHEMBL1945758)
Show SMILES NC(=O)c1ccc2cc(ccc2c1)C(=O)Nc1ccc(cc1)-c1cccc(Cl)c1
Show InChI InChI=1S/C24H17ClN2O2/c25-21-3-1-2-16(14-21)15-8-10-22(11-9-15)27-24(29)20-7-5-17-12-19(23(26)28)6-4-18(17)13-20/h1-14H,(H2,26,28)(H,27,29)
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n/an/a 8.10E+3n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA using pyroGlu-Gly-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by spectrop...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Tissue-type plasminogen activator


(Homo sapiens (Human))		BDBM50363660
PNG
(CHEMBL1945764)
Show SMILES COC(=O)c1cccc(c1)-c1ccc(NC(=O)c2ccc3cc(OC)ccc3c2)cc1
Show InChI InChI=1S/C26H21NO4/c1-30-24-13-10-19-14-21(7-6-20(19)16-24)25(28)27-23-11-8-17(9-12-23)18-4-3-5-22(15-18)26(29)31-2/h3-16H,1-2H3,(H,27,28)
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n/an/a 8.40E+3n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of recombinant tPA using H-D-Ile-Pro-Arg-pNA.2HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by sp...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Tissue-type plasminogen activator


(Homo sapiens (Human))		BDBM50363662
PNG
(CHEMBL1945766)
Show SMILES COc1ccc2cc(ccc2c1)C(=O)Nc1ccc(cc1)-c1cccc(c1)[N+]([O-])=O
Show InChI InChI=1S/C24H18N2O4/c1-30-23-12-9-18-13-20(6-5-19(18)15-23)24(27)25-21-10-7-16(8-11-21)17-3-2-4-22(14-17)26(28)29/h2-15H,1H3,(H,25,27)
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n/an/a 8.60E+3n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of recombinant tPA using H-D-Ile-Pro-Arg-pNA.2HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by sp...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50363681
PNG
(CHEMBL1945762)
Show SMILES COC(=O)c1cccc(c1)-c1ccc(NC(=O)c2ccc3cc(ccc3c2)C#N)cc1
Show InChI InChI=1S/C26H18N2O3/c1-31-26(30)23-4-2-3-19(15-23)18-9-11-24(12-10-18)28-25(29)22-8-7-20-13-17(16-27)5-6-21(20)14-22/h2-15H,1H3,(H,28,29)
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n/an/a 9.00E+3n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA using pyroGlu-Gly-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by spectrop...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Tissue-type plasminogen activator


(Homo sapiens (Human))		BDBM50363659
PNG
(CHEMBL1945759)
Show SMILES COc1ccc(cc1)-c1ccc(NC(=O)c2ccc3cc(ccc3c2)C(N)=O)cc1OC
Show InChI InChI=1S/C26H22N2O4/c1-31-22-10-7-16(8-11-22)23-12-9-21(15-24(23)32-2)28-26(30)20-6-4-17-13-19(25(27)29)5-3-18(17)14-20/h3-15H,1-2H3,(H2,27,29)(H,28,30)
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n/an/a 9.70E+3n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of recombinant tPA using H-D-Ile-Pro-Arg-pNA.2HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by sp...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50363677
PNG
(CHEMBL1945668)
Show SMILES COc1cccc(c1)-c1ccc(NC(=O)c2ccc3ccccc3c2)cc1
Show InChI InChI=1S/C24H19NO2/c1-27-23-8-4-7-20(16-23)18-11-13-22(14-12-18)25-24(26)21-10-9-17-5-2-3-6-19(17)15-21/h2-16H,1H3,(H,25,26)
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n/an/a 9.80E+3n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA using pyroGlu-Gly-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by spectrop...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50363690
PNG
(CHEMBL1945775)
Show SMILES COC(=O)c1ccc(cc1)-c1ccc(NS(=O)(=O)c2ccc3ccccc3c2)cc1
Show InChI InChI=1S/C24H19NO4S/c1-29-24(26)20-8-6-18(7-9-20)19-10-13-22(14-11-19)25-30(27,28)23-15-12-17-4-2-3-5-21(17)16-23/h2-16,25H,1H3
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n/an/a 9.80E+3n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA using pyroGlu-Gly-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by spectrop...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50363687
PNG
(CHEMBL1945772)
Show SMILES COC(=O)c1cccc(c1)-c1ccc(NC(=O)c2ccc3cc(Br)ccc3c2)cc1
Show InChI InChI=1S/C25H18BrNO3/c1-30-25(29)21-4-2-3-17(14-21)16-8-11-23(12-9-16)27-24(28)20-6-5-19-15-22(26)10-7-18(19)13-20/h2-15H,1H3,(H,27,28)
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n/an/a 1.10E+4n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA using pyroGlu-Gly-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by spectrop...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Tissue-type plasminogen activator


(Homo sapiens (Human))		BDBM50363656
PNG
(CHEMBL1945669)
Show SMILES COC(=O)c1cccc(c1)-c1ccc(NC(=O)c2ccc3cc(ccc3c2)C(N)=O)cc1
Show InChI InChI=1S/C26H20N2O4/c1-32-26(31)22-4-2-3-17(15-22)16-9-11-23(12-10-16)28-25(30)21-8-6-18-13-20(24(27)29)7-5-19(18)14-21/h2-15H,1H3,(H2,27,29)(H,28,30)
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n/an/a 1.10E+4n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of recombinant tPA using H-D-Ile-Pro-Arg-pNA.2HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by sp...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (Human))		BDBM50363657
PNG
(CHEMBL1945756)
Show SMILES COc1cccc(c1)-c1ccc(NC(=O)c2ccc3cc(ccc3c2)C(N)=O)cc1
Show InChI InChI=1S/C25H20N2O3/c1-30-23-4-2-3-17(15-23)16-9-11-22(12-10-16)27-25(29)21-8-6-18-13-20(24(26)28)7-5-19(18)14-21/h2-15H,1H3,(H2,26,28)(H,27,29)
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n/an/a 1.20E+4n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human plasma plasmin using pyroGlu-Pro-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins ...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50363683
PNG
(CHEMBL1945768)
Show SMILES COc1ccc(cc1)-c1ccc(NC(=O)c2ccc3cc(OC)ccc3c2)cc1
Show InChI InChI=1S/C25H21NO3/c1-28-23-12-7-18(8-13-23)17-5-10-22(11-6-17)26-25(27)21-4-3-20-16-24(29-2)14-9-19(20)15-21/h3-16H,1-2H3,(H,26,27)
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n/an/a 1.20E+4n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA using pyroGlu-Gly-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by spectrop...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50138670
PNG
(6-Carbamimidoyl-naphthalene-2-carboxylic acid phen...)
Show SMILES NC(=N)c1ccc2cc(ccc2c1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C18H15N3O/c19-17(20)14-8-6-13-11-15(9-7-12(13)10-14)18(22)21-16-4-2-1-3-5-16/h1-11H,(H3,19,20)(H,21,22)
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n/an/a 1.30E+4n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA using pyroGlu-Gly-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by spectrop...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Tissue-type plasminogen activator


(Homo sapiens (Human))		BDBM50363665
PNG
(CHEMBL1944651)
Show SMILES COc1ccc2cc(ccc2c1)S(=O)(=O)Nc1ccc(cc1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H18F3NO3S/c1-31-22-11-7-19-15-23(12-8-18(19)14-22)32(29,30)28-21-9-5-16(6-10-21)17-3-2-4-20(13-17)24(25,26)27/h2-15,28H,1H3
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n/an/a 1.30E+4n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of recombinant tPA using H-D-Ile-Pro-Arg-pNA.2HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by sp...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (Human))		BDBM50138678
PNG
(6-Carbamimidoyl-naphthalene-2-carboxylic acid (3,5...)
Show SMILES COc1cc(NC(=O)c2ccc3cc(ccc3c2)C(N)=N)cc(OC)c1
Show InChI InChI=1S/C20H19N3O3/c1-25-17-9-16(10-18(11-17)26-2)23-20(24)15-6-4-12-7-14(19(21)22)5-3-13(12)8-15/h3-11H,1-2H3,(H3,21,22)(H,23,24)
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n/an/a 1.30E+4n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human plasma plasmin using pyroGlu-Pro-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins ...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50363679
PNG
(CHEMBL1945760)
Show SMILES COC(=O)c1cccc(c1)-c1ccc(NC(=O)c2ccc3cc(ccc3c2)C(=O)OC)cc1
Show InChI InChI=1S/C27H21NO5/c1-32-26(30)22-5-3-4-18(15-22)17-10-12-24(13-11-17)28-25(29)21-8-6-20-16-23(27(31)33-2)9-7-19(20)14-21/h3-16H,1-2H3,(H,28,29)
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n/an/a 1.40E+4n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA using pyroGlu-Gly-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by spectrop...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50363666
PNG
(CHEMBL1945664)
Show SMILES NC(=O)c1ccc2cc(ccc2c1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C18H14N2O2/c19-17(21)14-8-6-13-11-15(9-7-12(13)10-14)18(22)20-16-4-2-1-3-5-16/h1-11H,(H2,19,21)(H,20,22)
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n/an/a 1.50E+4n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Non-competitive inhibition of human uPA using pyroGlu-Gly-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 ...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50363699
PNG
(CHEMBL1945925)
Show SMILES COC(=O)c1ccc(cc1)-c1ccc(NS(=O)(=O)c2ccc3cc(OC)ccc3c2)cc1
Show InChI InChI=1S/C25H21NO5S/c1-30-23-13-9-21-16-24(14-10-20(21)15-23)32(28,29)26-22-11-7-18(8-12-22)17-3-5-19(6-4-17)25(27)31-2/h3-16,26H,1-2H3
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n/an/a 1.60E+4n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA using pyroGlu-Gly-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by spectrop...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50363676
PNG
(CHEMBL1945667)
Show SMILES COC(=O)c1cccc(c1)-c1ccc(NC(=O)c2ccc3ccccc3c2)cc1
Show InChI InChI=1S/C25H19NO3/c1-29-25(28)22-8-4-7-20(16-22)18-11-13-23(14-12-18)26-24(27)21-10-9-17-5-2-3-6-19(17)15-21/h2-16H,1H3,(H,26,27)
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n/an/a 1.60E+4n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA using pyroGlu-Gly-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by spectrop...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50363689
PNG
(CHEMBL1945774)
Show SMILES COC(=O)c1cccc(c1)-c1ccc(NS(=O)(=O)c2ccc3ccccc3c2)cc1
Show InChI InChI=1S/C24H19NO4S/c1-29-24(26)21-8-4-7-19(15-21)18-9-12-22(13-10-18)25-30(27,28)23-14-11-17-5-2-3-6-20(17)16-23/h2-16,25H,1H3
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n/an/a 1.60E+4n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA using pyroGlu-Gly-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by spectrop...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50363696
PNG
(CHEMBL1945922)
Show SMILES COc1cccc(c1)-c1ccc(NS(=O)(=O)c2ccc3cc(OC)ccc3c2)cc1
Show InChI InChI=1S/C24H21NO4S/c1-28-22-5-3-4-18(14-22)17-6-10-21(11-7-17)25-30(26,27)24-13-9-19-15-23(29-2)12-8-20(19)16-24/h3-16,25H,1-2H3
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n/an/a 1.90E+4n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA using pyroGlu-Gly-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by spectrop...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (Human))		BDBM50363661
PNG
(CHEMBL1945765)
Show SMILES COc1cccc(c1)-c1ccc(NC(=O)c2ccc3cc(OC)ccc3c2)cc1
Show InChI InChI=1S/C25H21NO3/c1-28-23-5-3-4-18(15-23)17-8-11-22(12-9-17)26-25(27)21-7-6-20-16-24(29-2)13-10-19(20)14-21/h3-16H,1-2H3,(H,26,27)
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n/an/a 2.00E+4n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human plasma plasmin using pyroGlu-Pro-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins ...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50363680
PNG
(CHEMBL1945761)
Show SMILES COc1cccc(c1)-c1ccc(NC(=O)c2ccc3cc(ccc3c2)C#N)cc1
Show InChI InChI=1S/C25H18N2O2/c1-29-24-4-2-3-19(15-24)18-9-11-23(12-10-18)27-25(28)22-8-7-20-13-17(16-26)5-6-21(20)14-22/h2-15H,1H3,(H,27,28)
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n/an/a 2.00E+4n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA using pyroGlu-Gly-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by spectrop...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Tissue-type plasminogen activator


(Homo sapiens (Human))		BDBM50363661
PNG
(CHEMBL1945765)
Show SMILES COc1cccc(c1)-c1ccc(NC(=O)c2ccc3cc(OC)ccc3c2)cc1
Show InChI InChI=1S/C25H21NO3/c1-28-23-5-3-4-18(15-23)17-8-11-22(12-9-17)26-25(27)21-7-6-20-16-24(29-2)13-10-19(20)14-21/h3-16H,1-2H3,(H,26,27)
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n/an/a 2.10E+4n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of recombinant tPA using H-D-Ile-Pro-Arg-pNA.2HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by sp...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (Human))		BDBM50138670
PNG
(6-Carbamimidoyl-naphthalene-2-carboxylic acid phen...)
Show SMILES NC(=N)c1ccc2cc(ccc2c1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C18H15N3O/c19-17(20)14-8-6-13-11-15(9-7-12(13)10-14)18(22)21-16-4-2-1-3-5-16/h1-11H,(H3,19,20)(H,21,22)
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n/an/a 2.20E+4n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human plasma plasmin using pyroGlu-Pro-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins ...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50363700
PNG
(CHEMBL1945926)
Show SMILES COc1ccc(cc1)-c1ccc(NS(=O)(=O)c2ccc3cc(OC)ccc3c2)cc1
Show InChI InChI=1S/C24H21NO4S/c1-28-22-11-5-18(6-12-22)17-3-9-21(10-4-17)25-30(26,27)24-14-8-19-15-23(29-2)13-7-20(19)16-24/h3-16,25H,1-2H3
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n/an/a 2.30E+4n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA using pyroGlu-Gly-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by spectrop...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Tissue-type plasminogen activator


(Homo sapiens (Human))		BDBM50363664
PNG
(CHEMBL1945918)
Show SMILES COC(=O)c1cccc(c1)-c1ccc(NS(=O)(=O)c2ccc3cc(OC)ccc3c2)cc1
Show InChI InChI=1S/C25H21NO5S/c1-30-23-12-8-20-16-24(13-9-19(20)15-23)32(28,29)26-22-10-6-17(7-11-22)18-4-3-5-21(14-18)25(27)31-2/h3-16,26H,1-2H3
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n/an/a 2.60E+4n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of recombinant tPA using H-D-Ile-Pro-Arg-pNA.2HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by sp...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50363674
PNG
(CHEMBL1945665)
Show SMILES COc1cc(NC(=O)c2ccc3cc(ccc3c2)C(N)=O)cc(OC)c1
Show InChI InChI=1S/C20H18N2O4/c1-25-17-9-16(10-18(11-17)26-2)22-20(24)15-6-4-12-7-14(19(21)23)5-3-13(12)8-15/h3-11H,1-2H3,(H2,21,23)(H,22,24)
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n/an/a 3.00E+4n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA using pyroGlu-Gly-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by spectrop...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50363691
PNG
(CHEMBL1945776)
Show SMILES COc1cccc(c1)-c1ccc(NS(=O)(=O)c2ccc3ccccc3c2)cc1
Show InChI InChI=1S/C23H19NO3S/c1-27-22-8-4-7-19(15-22)18-9-12-21(13-10-18)24-28(25,26)23-14-11-17-5-2-3-6-20(17)16-23/h2-16,24H,1H3
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n/an/a 3.10E+4n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA using pyroGlu-Gly-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by spectrop...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50363688
PNG
(CHEMBL1945773)
Show SMILES COC(=O)c1cccc(c1)-c1ccc(NC(=O)c2ccc3cc(N)ccc3c2)cc1
Show InChI InChI=1S/C25H20N2O3/c1-30-25(29)21-4-2-3-17(14-21)16-8-11-23(12-9-16)27-24(28)20-6-5-19-15-22(26)10-7-18(19)13-20/h2-15H,26H2,1H3,(H,27,28)
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n/an/a 3.10E+4n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA using pyroGlu-Gly-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by spectrop...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (Human))		BDBM50363662
PNG
(CHEMBL1945766)
Show SMILES COc1ccc2cc(ccc2c1)C(=O)Nc1ccc(cc1)-c1cccc(c1)[N+]([O-])=O
Show InChI InChI=1S/C24H18N2O4/c1-30-23-12-9-18-13-20(6-5-19(18)15-23)24(27)25-21-10-7-16(8-11-21)17-3-2-4-22(14-17)26(28)29/h2-15H,1H3,(H,25,27)
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n/an/a 3.10E+4n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human plasma plasmin using pyroGlu-Pro-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins ...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50363692
PNG
(CHEMBL1945777)
Show SMILES COc1ccc2cc(ccc2c1)S(=O)(=O)Nc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C23H19NO3S/c1-27-22-13-9-20-16-23(14-10-19(20)15-22)28(25,26)24-21-11-7-18(8-12-21)17-5-3-2-4-6-17/h2-16,24H,1H3
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n/an/a 3.10E+4n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA using pyroGlu-Gly-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by spectrop...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50363685
PNG
(CHEMBL1945770)
Show SMILES COc1ccc(cc1)-c1ccc(NC(=O)c2ccc3cc(OC)ccc3c2)cc1OC
Show InChI InChI=1S/C26H23NO4/c1-29-22-10-6-17(7-11-22)24-13-9-21(16-25(24)31-3)27-26(28)20-5-4-19-15-23(30-2)12-8-18(19)14-20/h4-16H,1-3H3,(H,27,28)
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n/an/a>3.10E+4n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA using pyroGlu-Gly-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by spectrop...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50363684
PNG
(CHEMBL1945769)
Show SMILES COc1ccc2cc(ccc2c1)C(=O)Nc1ccc(cc1)-c1ccc(OC)c(OC)c1
Show InChI InChI=1S/C26H23NO4/c1-29-23-12-8-18-14-21(5-4-19(18)15-23)26(28)27-22-10-6-17(7-11-22)20-9-13-24(30-2)25(16-20)31-3/h4-16H,1-3H3,(H,27,28)
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n/an/a 3.10E+4n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA using pyroGlu-Gly-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by spectrop...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50363675
PNG
(CHEMBL1945666)
Show SMILES NCc1ccc(NC(=O)c2ccc3cc(ccc3c2)C(N)=O)cc1
Show InChI InChI=1S/C19H17N3O2/c20-11-12-1-7-17(8-2-12)22-19(24)16-6-4-13-9-15(18(21)23)5-3-14(13)10-16/h1-10H,11,20H2,(H2,21,23)(H,22,24)
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n/an/a 4.50E+4n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA using pyroGlu-Gly-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by spectrop...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))		BDBM50138670
PNG
(6-Carbamimidoyl-naphthalene-2-carboxylic acid phen...)
Show SMILES NC(=N)c1ccc2cc(ccc2c1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C18H15N3O/c19-17(20)14-8-6-13-11-15(9-7-12(13)10-14)18(22)21-16-4-2-1-3-5-16/h1-11H,(H3,19,20)(H,21,22)
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n/an/a 5.60E+4n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human plasma thrombin using pyroGlu-Pro-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))		BDBM50138662
PNG
(6-Carbamimidoyl-naphthalene-2-carboxylic acid (4-a...)
Show SMILES NCc1ccc(NC(=O)c2ccc3cc(ccc3c2)C(N)=N)cc1
Show InChI InChI=1S/C19H18N4O/c20-11-12-1-7-17(8-2-12)23-19(24)16-6-4-13-9-15(18(21)22)5-3-14(13)10-16/h1-10H,11,20H2,(H3,21,22)(H,23,24)
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n/an/a>6.20E+4n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human plasma thrombin using pyroGlu-Pro-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50363668
PNG
(CHEMBL1945238)
Show SMILES O=C(Nc1ccccc1)c1ccc2ccccc2c1
Show InChI InChI=1S/C17H13NO/c19-17(18-16-8-2-1-3-9-16)15-11-10-13-6-4-5-7-14(13)12-15/h1-12H,(H,18,19)
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n/an/a>6.20E+4n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA using pyroGlu-Gly-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by spectrop...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))		BDBM50363663
PNG
(CHEMBL1945767)
Show SMILES COc1ccc2cc(ccc2c1)C(=O)Nc1ccc(cc1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C25H18F3NO2/c1-31-23-12-9-18-13-20(6-5-19(18)15-23)24(30)29-22-10-7-16(8-11-22)17-3-2-4-21(14-17)25(26,27)28/h2-15H,1H3,(H,29,30)
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n/an/a>6.20E+4n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human plasma thrombin using pyroGlu-Pro-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (Human))		BDBM50363664
PNG
(CHEMBL1945918)
Show SMILES COC(=O)c1cccc(c1)-c1ccc(NS(=O)(=O)c2ccc3cc(OC)ccc3c2)cc1
Show InChI InChI=1S/C25H21NO5S/c1-30-23-12-8-20-16-24(13-9-19(20)15-23)32(28,29)26-22-10-6-17(7-11-22)18-4-3-5-21(14-18)25(27)31-2/h3-16,26H,1-2H3
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n/an/a>6.20E+4n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human plasma plasmin using pyroGlu-Pro-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins ...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))		BDBM50363664
PNG
(CHEMBL1945918)
Show SMILES COC(=O)c1cccc(c1)-c1ccc(NS(=O)(=O)c2ccc3cc(OC)ccc3c2)cc1
Show InChI InChI=1S/C25H21NO5S/c1-30-23-12-8-20-16-24(13-9-19(20)15-23)32(28,29)26-22-10-6-17(7-11-22)18-4-3-5-21(14-18)25(27)31-2/h3-16,26H,1-2H3
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n/an/a>6.20E+4n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human plasma thrombin using pyroGlu-Pro-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50363673
PNG
(CHEMBL1945663)
Show SMILES OC(=O)c1ccc2cc(ccc2c1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C18H13NO3/c20-17(19-16-4-2-1-3-5-16)14-8-6-13-11-15(18(21)22)9-7-12(13)10-14/h1-11H,(H,19,20)(H,21,22)
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n/an/a>6.20E+4n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA using pyroGlu-Gly-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by spectrop...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))		BDBM50138678
PNG
(6-Carbamimidoyl-naphthalene-2-carboxylic acid (3,5...)
Show SMILES COc1cc(NC(=O)c2ccc3cc(ccc3c2)C(N)=N)cc(OC)c1
Show InChI InChI=1S/C20H19N3O3/c1-25-17-9-16(10-18(11-17)26-2)23-20(24)15-6-4-12-7-14(19(21)22)5-3-13(12)8-15/h3-11H,1-2H3,(H3,21,22)(H,23,24)
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n/an/a>6.20E+4n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human plasma thrombin using pyroGlu-Pro-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50363667
PNG
(CHEMBL1945237)
Show SMILES O=C(Nc1ccccc1)c1ccc2cc(ccc2c1)C#N
Show InChI InChI=1S/C18H12N2O/c19-12-13-6-7-15-11-16(9-8-14(15)10-13)18(21)20-17-4-2-1-3-5-17/h1-11H,(H,20,21)
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n/an/a>6.20E+4n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA using pyroGlu-Gly-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by spectrop...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50363671
PNG
(CHEMBL1945241)
Show SMILES COc1ccc2cc(ccc2c1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C18H15NO2/c1-21-17-10-9-13-11-15(8-7-14(13)12-17)18(20)19-16-5-3-2-4-6-16/h2-12H,1H3,(H,19,20)
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n/an/a>6.20E+4n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA using pyroGlu-Gly-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by spectrop...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50363694
PNG
(CHEMBL1945920)
Show SMILES COc1ccc2cc(ccc2c1)S(=O)(=O)Nc1ccc(cc1)-c1cccc(F)c1
Show InChI InChI=1S/C23H18FNO3S/c1-28-22-11-7-19-15-23(12-8-18(19)14-22)29(26,27)25-21-9-5-16(6-10-21)17-3-2-4-20(24)13-17/h2-15,25H,1H3
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n/an/a>6.20E+4n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA using pyroGlu-Gly-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by spectrop...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (Human))		BDBM50138662
PNG
(6-Carbamimidoyl-naphthalene-2-carboxylic acid (4-a...)
Show SMILES NCc1ccc(NC(=O)c2ccc3cc(ccc3c2)C(N)=N)cc1
Show InChI InChI=1S/C19H18N4O/c20-11-12-1-7-17(8-2-12)23-19(24)16-6-4-13-9-15(18(21)22)5-3-14(13)10-16/h1-10H,11,20H2,(H3,21,22)(H,23,24)
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n/an/a>6.20E+4n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human plasma plasmin using pyroGlu-Pro-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins ...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50363698
PNG
(CHEMBL1945924)
Show SMILES COc1ccc2cc(ccc2c1)S(=O)(=O)Nc1ccc(cc1)-c1cccc(N)c1
Show InChI InChI=1S/C23H20N2O3S/c1-28-22-11-7-19-15-23(12-8-18(19)14-22)29(26,27)25-21-9-5-16(6-10-21)17-3-2-4-20(24)13-17/h2-15,25H,24H2,1H3
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n/an/a 6.20E+4n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA using pyroGlu-Gly-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by spectrop...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))		BDBM50363660
PNG
(CHEMBL1945764)
Show SMILES COC(=O)c1cccc(c1)-c1ccc(NC(=O)c2ccc3cc(OC)ccc3c2)cc1
Show InChI InChI=1S/C26H21NO4/c1-30-24-13-10-19-14-21(7-6-20(19)16-24)25(28)27-23-11-8-17(9-12-23)18-4-3-5-22(15-18)26(29)31-2/h3-16H,1-2H3,(H,27,28)
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n/an/a>6.20E+4n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human plasma thrombin using pyroGlu-Pro-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))		BDBM50363661
PNG
(CHEMBL1945765)
Show SMILES COc1cccc(c1)-c1ccc(NC(=O)c2ccc3cc(OC)ccc3c2)cc1
Show InChI InChI=1S/C25H21NO3/c1-28-23-5-3-4-18(15-23)17-8-11-22(12-9-17)26-25(27)21-7-6-20-16-24(29-2)13-10-19(20)14-21/h3-16H,1-2H3,(H,26,27)
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n/an/a>6.20E+4n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human plasma thrombin using pyroGlu-Pro-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))		BDBM50363662
PNG
(CHEMBL1945766)
Show SMILES COc1ccc2cc(ccc2c1)C(=O)Nc1ccc(cc1)-c1cccc(c1)[N+]([O-])=O
Show InChI InChI=1S/C24H18N2O4/c1-30-23-12-9-18-13-20(6-5-19(18)15-23)24(27)25-21-10-7-16(8-11-21)17-3-2-4-22(14-17)26(28)29/h2-15H,1H3,(H,25,27)
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n/an/a>6.20E+4n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human plasma thrombin using pyroGlu-Pro-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Tissue-type plasminogen activator


(Homo sapiens (Human))		BDBM50138662
PNG
(6-Carbamimidoyl-naphthalene-2-carboxylic acid (4-a...)
Show SMILES NCc1ccc(NC(=O)c2ccc3cc(ccc3c2)C(N)=N)cc1
Show InChI InChI=1S/C19H18N4O/c20-11-12-1-7-17(8-2-12)23-19(24)16-6-4-13-9-15(18(21)22)5-3-14(13)10-16/h1-10H,11,20H2,(H3,21,22)(H,23,24)
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n/an/a>6.20E+4n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of recombinant tPA using H-D-Ile-Pro-Arg-pNA.2HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by sp...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50363693
PNG
(CHEMBL1945919)
Show SMILES COc1ccc2cc(ccc2c1)S(=O)(=O)Nc1ccc(cc1)-c1cccc(c1)C(N)=O
Show InChI InChI=1S/C24H20N2O4S/c1-30-22-11-7-19-15-23(12-8-18(19)14-22)31(28,29)26-21-9-5-16(6-10-21)17-3-2-4-20(13-17)24(25)27/h2-15,26H,1H3,(H2,25,27)
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n/an/a>6.20E+4n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA using pyroGlu-Gly-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by spectrop...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))		BDBM50363657
PNG
(CHEMBL1945756)
Show SMILES COc1cccc(c1)-c1ccc(NC(=O)c2ccc3cc(ccc3c2)C(N)=O)cc1
Show InChI InChI=1S/C25H20N2O3/c1-30-23-4-2-3-17(15-23)16-9-11-22(12-10-16)27-25(29)21-8-6-18-13-20(24(26)28)7-5-19(18)14-21/h2-15H,1H3,(H2,26,28)(H,27,29)
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n/an/a>6.20E+4n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human plasma thrombin using pyroGlu-Pro-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))		BDBM50363658
PNG
(CHEMBL1945757)
Show SMILES NC(=O)c1ccc2cc(ccc2c1)C(=O)Nc1ccc(cc1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C25H17F3N2O2/c26-25(27,28)21-3-1-2-16(14-21)15-8-10-22(11-9-15)30-24(32)20-7-5-17-12-19(23(29)31)6-4-18(17)13-20/h1-14H,(H2,29,31)(H,30,32)
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n/an/a>6.20E+4n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human plasma thrombin using pyroGlu-Pro-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50363695
PNG
(CHEMBL1945921)
Show SMILES COc1ccc2cc(ccc2c1)S(=O)(=O)Nc1ccc(cc1)-c1cccc(Cl)c1
Show InChI InChI=1S/C23H18ClNO3S/c1-28-22-11-7-19-15-23(12-8-18(19)14-22)29(26,27)25-21-9-5-16(6-10-21)17-3-2-4-20(24)13-17/h2-15,25H,1H3
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n/an/a>6.20E+4n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA using pyroGlu-Gly-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by spectrop...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Tissue-type plasminogen activator


(Homo sapiens (Human))		BDBM50138678
PNG
(6-Carbamimidoyl-naphthalene-2-carboxylic acid (3,5...)
Show SMILES COc1cc(NC(=O)c2ccc3cc(ccc3c2)C(N)=N)cc(OC)c1
Show InChI InChI=1S/C20H19N3O3/c1-25-17-9-16(10-18(11-17)26-2)23-20(24)15-6-4-12-7-14(19(21)22)5-3-13(12)8-15/h3-11H,1-2H3,(H3,21,22)(H,23,24)
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n/an/a>6.20E+4n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of recombinant tPA using H-D-Ile-Pro-Arg-pNA.2HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by sp...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50363669
PNG
(CHEMBL1945239)
Show SMILES Brc1ccc2cc(ccc2c1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C17H12BrNO/c18-15-9-8-12-10-14(7-6-13(12)11-15)17(20)19-16-4-2-1-3-5-16/h1-11H,(H,19,20)
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n/an/a>6.20E+4n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA using pyroGlu-Gly-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by spectrop...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50363670
PNG
(CHEMBL1945240)
Show SMILES Nc1ccc2cc(ccc2c1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C17H14N2O/c18-15-9-8-12-10-14(7-6-13(12)11-15)17(20)19-16-4-2-1-3-5-16/h1-11H,18H2,(H,19,20)
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n/an/a>6.20E+4n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA using pyroGlu-Gly-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by spectrop...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50363672
PNG
(CHEMBL1945242)
Show SMILES COC(=O)c1ccc2cc(ccc2c1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C19H15NO3/c1-23-19(22)16-10-8-13-11-15(9-7-14(13)12-16)18(21)20-17-5-3-2-4-6-17/h2-12H,1H3,(H,20,21)
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n/an/a>6.20E+4n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA using pyroGlu-Gly-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by spectrop...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))		BDBM50363655
PNG
(CHEMBL1945236)
Show SMILES NC(=N)c1ccc(\C=C2\N=C(OC2=O)c2ccccc2)cc1 |c:9|
Show InChI InChI=1S/C17H13N3O2/c18-15(19)12-8-6-11(7-9-12)10-14-17(21)22-16(20-14)13-4-2-1-3-5-13/h1-10H,(H3,18,19)/b14-10+
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human plasma thrombin using pyroGlu-Pro-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Tissue-type plasminogen activator


(Homo sapiens (Human))		BDBM50363655
PNG
(CHEMBL1945236)
Show SMILES NC(=N)c1ccc(\C=C2\N=C(OC2=O)c2ccccc2)cc1 |c:9|
Show InChI InChI=1S/C17H13N3O2/c18-15(19)12-8-6-11(7-9-12)10-14-17(21)22-16(20-14)13-4-2-1-3-5-13/h1-10H,(H3,18,19)/b14-10+
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of recombinant tPA using H-D-Ile-Pro-Arg-pNA.2HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by sp...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (Human))		BDBM50363655
PNG
(CHEMBL1945236)
Show SMILES NC(=N)c1ccc(\C=C2\N=C(OC2=O)c2ccccc2)cc1 |c:9|
Show InChI InChI=1S/C17H13N3O2/c18-15(19)12-8-6-11(7-9-12)10-14-17(21)22-16(20-14)13-4-2-1-3-5-13/h1-10H,(H3,18,19)/b14-10+
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human plasma plasmin using pyroGlu-Pro-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins ...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))		BDBM50363656
PNG
(CHEMBL1945669)
Show SMILES COC(=O)c1cccc(c1)-c1ccc(NC(=O)c2ccc3cc(ccc3c2)C(N)=O)cc1
Show InChI InChI=1S/C26H20N2O4/c1-32-26(31)22-4-2-3-17(15-22)16-9-11-23(12-10-16)28-25(30)21-8-6-18-13-20(24(27)29)7-5-19(18)14-21/h2-15H,1H3,(H2,27,29)(H,28,30)
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n/an/a>1.25E+5n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human plasma thrombin using pyroGlu-Pro-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (Human))		BDBM50363656
PNG
(CHEMBL1945669)
Show SMILES COC(=O)c1cccc(c1)-c1ccc(NC(=O)c2ccc3cc(ccc3c2)C(N)=O)cc1
Show InChI InChI=1S/C26H20N2O4/c1-32-26(31)22-4-2-3-17(15-22)16-9-11-23(12-10-16)28-25(30)21-8-6-18-13-20(24(27)29)7-5-19(18)14-21/h2-15H,1H3,(H2,27,29)(H,28,30)
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n/an/a>1.25E+5n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human plasma plasmin using pyroGlu-Pro-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins ...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Tissue-type plasminogen activator


(Homo sapiens (Human))		BDBM50138670
PNG
(6-Carbamimidoyl-naphthalene-2-carboxylic acid phen...)
Show SMILES NC(=N)c1ccc2cc(ccc2c1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C18H15N3O/c19-17(20)14-8-6-13-11-15(9-7-12(13)10-14)18(22)21-16-4-2-1-3-5-16/h1-11H,(H3,19,20)(H,21,22)
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n/an/a 1.25E+5n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of recombinant tPA using H-D-Ile-Pro-Arg-pNA.2HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by sp...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))		BDBM50363682
PNG
(CHEMBL1945763)
Show SMILES OC(=O)c1cccc(c1)-c1ccc(NC(=O)c2ccc3cc(ccc3c2)C#N)cc1
Show InChI InChI=1S/C25H16N2O3/c26-15-16-4-5-20-13-21(7-6-19(20)12-16)24(28)27-23-10-8-17(9-11-23)18-2-1-3-22(14-18)25(29)30/h1-14H,(H,27,28)(H,29,30)
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n/an/a>2.50E+5n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA using pyroGlu-Gly-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by spectrop...

Bioorg Med Chem 20: 1557-68 (2012)


Article DOI: 10.1016/j.bmc.2011.12.040
BindingDB Entry DOI: 10.7270/Q2QR4XK1
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%