Affinity Data by PubMed id=22336246

PubMed code 22336246

Found 7 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50315213 (2-(difluoromethyl)-1-(4,6-dimorpholin-4-yl-1,3,5-t...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics Curated by ChEMBL					Assay Description Inhibition of recombinant PI3Kdelta HTRF assay				Bioorg Med Chem 20: 1947-51 (2012) Article DOI: 10.1016/j.bmc.2012.01.017 BindingDB Entry DOI: 10.7270/Q21G0MQM
					More data for this Ligand-Target Pair				3D Structure (crystal)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM50315213 (2-(difluoromethyl)-1-(4,6-dimorpholin-4-yl-1,3,5-t...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics Curated by ChEMBL					Assay Description Inhibition of recombinant PI3Kalpha by HTRF assay				Bioorg Med Chem 20: 1947-51 (2012) Article DOI: 10.1016/j.bmc.2012.01.017 BindingDB Entry DOI: 10.7270/Q21G0MQM
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Homo sapiens (Human))	BDBM50315213 (2-(difluoromethyl)-1-(4,6-dimorpholin-4-yl-1,3,5-t...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	44	n/a	n/a	n/a	n/a	n/a	n/a
Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics Curated by ChEMBL					Assay Description Inhibition of recombinant PI3Kbeta HTRF assay				Bioorg Med Chem 20: 1947-51 (2012) Article DOI: 10.1016/j.bmc.2012.01.017 BindingDB Entry DOI: 10.7270/Q21G0MQM
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human))	BDBM50315213 (2-(difluoromethyl)-1-(4,6-dimorpholin-4-yl-1,3,5-t...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	49	n/a	n/a	n/a	n/a	n/a	n/a
Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics Curated by ChEMBL					Assay Description Inhibition of recombinant PI3Kgamma HTRF assay				Bioorg Med Chem 20: 1947-51 (2012) Article DOI: 10.1016/j.bmc.2012.01.017 BindingDB Entry DOI: 10.7270/Q21G0MQM
					More data for this Ligand-Target Pair
Telomerase reverse transcriptase (Homo sapiens (Human))	BDBM50365736 (CHEMBL1956189) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics Curated by ChEMBL					Assay Description Inhibition of telomerase				Bioorg Med Chem 20: 1947-51 (2012) Article DOI: 10.1016/j.bmc.2012.01.017 BindingDB Entry DOI: 10.7270/Q21G0MQM
					More data for this Ligand-Target Pair
Telomerase reverse transcriptase (Homo sapiens (Human))	BDBM50365735 (CHEMBL33859 \| MKT-077 \| US20230414581, Compound 39) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics Curated by ChEMBL					Assay Description Inhibition of telomerase				Bioorg Med Chem 20: 1947-51 (2012) Article DOI: 10.1016/j.bmc.2012.01.017 BindingDB Entry DOI: 10.7270/Q21G0MQM
					More data for this Ligand-Target Pair
Telomerase reverse transcriptase (Homo sapiens (Human))	BDBM50203126 (3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...) Show SMILES COc1ccc2cc3-c4cc5OCOc5cc4CC[n+]3cc2c1OC Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	3.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics Curated by ChEMBL					Assay Description Inhibition of telomerase				Bioorg Med Chem 20: 1947-51 (2012) Article DOI: 10.1016/j.bmc.2012.01.017 BindingDB Entry DOI: 10.7270/Q21G0MQM
					More data for this Ligand-Target Pair

* indicates data uncertainty>20%