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PubMed code 22341572

Compile data set for download or QSAR
Found 61 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM21281
PNG
((11R)-2-methyl-11-(morpholin-4-ylmethyl)-3-(naphth...)
Show SMILES Cc1c(C(=O)c2cccc3ccccc23)c2cccc3OC[C@@H](CN4CCOCC4)n1c23 |r|
Show InChI InChI=1S/C27H26N2O3/c1-18-25(27(30)22-9-4-7-19-6-2-3-8-21(19)22)23-10-5-11-24-26(23)29(18)20(17-32-24)16-28-12-14-31-15-13-28/h2-11,20H,12-17H2,1H3/t20-/m1/s1
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0.280n/an/an/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Binding affinity to human CB2 receptor by filtration assay


Bioorg Med Chem 20: 2067-81 (2012)


Article DOI: 10.1016/j.bmc.2012.01.038
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50401063
PNG
(CHEMBL2206834)
Show SMILES CCCCCn1cc(C(=O)c2ccc(Br)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C24H22BrNO/c1-2-3-8-15-26-16-21(19-11-6-7-12-23(19)26)24(27)20-13-14-22(25)18-10-5-4-9-17(18)20/h4-7,9-14,16H,2-3,8,15H2,1H3
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1.10n/an/an/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB2 receptor expressed in CHO cells after 1 hr by liquid scintillation spectrophotometry


Bioorg Med Chem 20: 2067-81 (2012)


Article DOI: 10.1016/j.bmc.2012.01.038
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50401063
PNG
(CHEMBL2206834)
Show SMILES CCCCCn1cc(C(=O)c2ccc(Br)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C24H22BrNO/c1-2-3-8-15-26-16-21(19-11-6-7-12-23(19)26)24(27)20-13-14-22(25)18-10-5-4-9-17(18)20/h4-7,9-14,16H,2-3,8,15H2,1H3
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1.20n/an/an/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB1 receptor expressed in HEK293 cells after 1 hr by liquid scintillation spectrophotometry


Bioorg Med Chem 20: 2067-81 (2012)


Article DOI: 10.1016/j.bmc.2012.01.038
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50401059
PNG
(CHEMBL2206838)
Show SMILES CCCCCn1cc(C(=O)c2ccc(I)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C24H22INO/c1-2-3-8-15-26-16-21(19-11-6-7-12-23(19)26)24(27)20-13-14-22(25)18-10-5-4-9-17(18)20/h4-7,9-14,16H,2-3,8,15H2,1H3
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1.30n/an/an/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB2 receptor expressed in CHO cells after 1 hr by liquid scintillation spectrophotometry


Bioorg Med Chem 20: 2067-81 (2012)


Article DOI: 10.1016/j.bmc.2012.01.038
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM21281
PNG
((11R)-2-methyl-11-(morpholin-4-ylmethyl)-3-(naphth...)
Show SMILES Cc1c(C(=O)c2cccc3ccccc23)c2cccc3OC[C@@H](CN4CCOCC4)n1c23 |r|
Show InChI InChI=1S/C27H26N2O3/c1-18-25(27(30)22-9-4-7-19-6-2-3-8-21(19)22)23-10-5-11-24-26(23)29(18)20(17-32-24)16-28-12-14-31-15-13-28/h2-11,20H,12-17H2,1H3/t20-/m1/s1
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1.90n/an/an/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Binding affinity to human CB1 receptor by filtration assay


Bioorg Med Chem 20: 2067-81 (2012)


Article DOI: 10.1016/j.bmc.2012.01.038
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50401058
PNG
(CHEMBL2206839)
Show SMILES CCCCCn1c(C)c(C(=O)c2ccc(I)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C25H24INO/c1-3-4-9-16-27-17(2)24(21-12-7-8-13-23(21)27)25(28)20-14-15-22(26)19-11-6-5-10-18(19)20/h5-8,10-15H,3-4,9,16H2,1-2H3
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2.10n/an/an/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB2 receptor expressed in CHO cells after 1 hr by liquid scintillation spectrophotometry


Bioorg Med Chem 20: 2067-81 (2012)


Article DOI: 10.1016/j.bmc.2012.01.038
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50401070
PNG
(CHEMBL2206856)
Show SMILES CCCCCn1c(C)c(C(=O)c2ccc(F)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C25H24FNO/c1-3-4-9-16-27-17(2)24(21-12-7-8-13-23(21)27)25(28)20-14-15-22(26)19-11-6-5-10-18(19)20/h5-8,10-15H,3-4,9,16H2,1-2H3
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2.20n/an/an/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB2 receptor expressed in CHO cells after 1 hr by liquid scintillation spectrophotometry


Bioorg Med Chem 20: 2067-81 (2012)


Article DOI: 10.1016/j.bmc.2012.01.038
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50401066
PNG
(CHEMBL2206860)
Show SMILES CCCCCn1c(C)c(C(=O)c2ccc(Cl)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C25H24ClNO/c1-3-4-9-16-27-17(2)24(21-12-7-8-13-23(21)27)25(28)20-14-15-22(26)19-11-6-5-10-18(19)20/h5-8,10-15H,3-4,9,16H2,1-2H3
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2.30n/an/an/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB2 receptor expressed in CHO cells after 1 hr by liquid scintillation spectrophotometry


Bioorg Med Chem 20: 2067-81 (2012)


Article DOI: 10.1016/j.bmc.2012.01.038
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50401067
PNG
(CHEMBL2206859)
Show SMILES CCCCCn1cc(C(=O)c2ccc(Cl)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C24H22ClNO/c1-2-3-8-15-26-16-21(19-11-6-7-12-23(19)26)24(27)20-13-14-22(25)18-10-5-4-9-17(18)20/h4-7,9-14,16H,2-3,8,15H2,1H3
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2.30n/an/an/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB1 receptor expressed in HEK293 cells after 1 hr by liquid scintillation spectrophotometry


Bioorg Med Chem 20: 2067-81 (2012)


Article DOI: 10.1016/j.bmc.2012.01.038
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50401059
PNG
(CHEMBL2206838)
Show SMILES CCCCCn1cc(C(=O)c2ccc(I)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C24H22INO/c1-2-3-8-15-26-16-21(19-11-6-7-12-23(19)26)24(27)20-13-14-22(25)18-10-5-4-9-17(18)20/h4-7,9-14,16H,2-3,8,15H2,1H3
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2.5n/an/an/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB1 receptor expressed in HEK293 cells after 1 hr by liquid scintillation spectrophotometry


Bioorg Med Chem 20: 2067-81 (2012)


Article DOI: 10.1016/j.bmc.2012.01.038
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50401067
PNG
(CHEMBL2206859)
Show SMILES CCCCCn1cc(C(=O)c2ccc(Cl)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C24H22ClNO/c1-2-3-8-15-26-16-21(19-11-6-7-12-23(19)26)24(27)20-13-14-22(25)18-10-5-4-9-17(18)20/h4-7,9-14,16H,2-3,8,15H2,1H3
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2.80n/an/an/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB2 receptor expressed in CHO cells after 1 hr by liquid scintillation spectrophotometry


Bioorg Med Chem 20: 2067-81 (2012)


Article DOI: 10.1016/j.bmc.2012.01.038
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50401062
PNG
(CHEMBL2206835)
Show SMILES CCCCCn1c(C)c(C(=O)c2ccc(Br)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C25H24BrNO/c1-3-4-9-16-27-17(2)24(21-12-7-8-13-23(21)27)25(28)20-14-15-22(26)19-11-6-5-10-18(19)20/h5-8,10-15H,3-4,9,16H2,1-2H3
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2.80n/an/an/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB2 receptor expressed in CHO cells after 1 hr by liquid scintillation spectrophotometry


Bioorg Med Chem 20: 2067-81 (2012)


Article DOI: 10.1016/j.bmc.2012.01.038
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50401071
PNG
(CHEMBL2206855)
Show SMILES CCCCCn1cc(C(=O)c2ccc(F)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C24H22FNO/c1-2-3-8-15-26-16-21(19-11-6-7-12-23(19)26)24(27)20-13-14-22(25)18-10-5-4-9-17(18)20/h4-7,9-14,16H,2-3,8,15H2,1H3
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3.20n/an/an/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB2 receptor expressed in CHO cells after 1 hr by liquid scintillation spectrophotometry


Bioorg Med Chem 20: 2067-81 (2012)


Article DOI: 10.1016/j.bmc.2012.01.038
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50401047
PNG
(CHEMBL2206850)
Show SMILES CCCCCn1cc(C(=O)c2cccc3cccc(I)c23)c2ccccc12
Show InChI InChI=1S/C24H22INO/c1-2-3-6-15-26-16-20(18-11-4-5-14-22(18)26)24(27)19-12-7-9-17-10-8-13-21(25)23(17)19/h4-5,7-14,16H,2-3,6,15H2,1H3
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3.30n/an/an/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB2 receptor expressed in CHO cells after 1 hr by liquid scintillation spectrophotometry


Bioorg Med Chem 20: 2067-81 (2012)


Article DOI: 10.1016/j.bmc.2012.01.038
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50401051
PNG
(CHEMBL2206846)
Show SMILES CCCCCn1cc(C(=O)c2cccc3cccc(Br)c23)c2ccccc12
Show InChI InChI=1S/C24H22BrNO/c1-2-3-6-15-26-16-20(18-11-4-5-14-22(18)26)24(27)19-12-7-9-17-10-8-13-21(25)23(17)19/h4-5,7-14,16H,2-3,6,15H2,1H3
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5.40n/an/an/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB2 receptor expressed in CHO cells after 1 hr by liquid scintillation spectrophotometry


Bioorg Med Chem 20: 2067-81 (2012)


Article DOI: 10.1016/j.bmc.2012.01.038
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50401061
PNG
(CHEMBL2206836)
Show SMILES CCCn1cc(C(=O)c2ccc(I)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C22H18INO/c1-2-13-24-14-19(17-9-5-6-10-21(17)24)22(25)18-11-12-20(23)16-8-4-3-7-15(16)18/h3-12,14H,2,13H2,1H3
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6.60n/an/an/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB2 receptor expressed in CHO cells after 1 hr by liquid scintillation spectrophotometry


Bioorg Med Chem 20: 2067-81 (2012)


Article DOI: 10.1016/j.bmc.2012.01.038
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50401071
PNG
(CHEMBL2206855)
Show SMILES CCCCCn1cc(C(=O)c2ccc(F)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C24H22FNO/c1-2-3-8-15-26-16-21(19-11-6-7-12-23(19)26)24(27)20-13-14-22(25)18-10-5-4-9-17(18)20/h4-7,9-14,16H,2-3,8,15H2,1H3
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7.20n/an/an/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB1 receptor expressed in HEK293 cells after 1 hr by liquid scintillation spectrophotometry


Bioorg Med Chem 20: 2067-81 (2012)


Article DOI: 10.1016/j.bmc.2012.01.038
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50401066
PNG
(CHEMBL2206860)
Show SMILES CCCCCn1c(C)c(C(=O)c2ccc(Cl)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C25H24ClNO/c1-3-4-9-16-27-17(2)24(21-12-7-8-13-23(21)27)25(28)20-14-15-22(26)19-11-6-5-10-18(19)20/h5-8,10-15H,3-4,9,16H2,1-2H3
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8.90n/an/an/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB1 receptor expressed in HEK293 cells after 1 hr by liquid scintillation spectrophotometry


Bioorg Med Chem 20: 2067-81 (2012)


Article DOI: 10.1016/j.bmc.2012.01.038
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50401050
PNG
(CHEMBL2206847)
Show SMILES CCCCCn1c(C)c(C(=O)c2cccc3cccc(Br)c23)c2ccccc12
Show InChI InChI=1S/C25H24BrNO/c1-3-4-7-16-27-17(2)23(19-12-5-6-15-22(19)27)25(28)20-13-8-10-18-11-9-14-21(26)24(18)20/h5-6,8-15H,3-4,7,16H2,1-2H3
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10n/an/an/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB2 receptor expressed in CHO cells after 1 hr by liquid scintillation spectrophotometry


Bioorg Med Chem 20: 2067-81 (2012)


Article DOI: 10.1016/j.bmc.2012.01.038
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50401055
PNG
(CHEMBL2206842)
Show SMILES CCCCCn1cc(C(=O)c2cccc3cccc(Cl)c23)c2ccccc12
Show InChI InChI=1S/C24H22ClNO/c1-2-3-6-15-26-16-20(18-11-4-5-14-22(18)26)24(27)19-12-7-9-17-10-8-13-21(25)23(17)19/h4-5,7-14,16H,2-3,6,15H2,1H3
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10n/an/an/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB2 receptor expressed in CHO cells after 1 hr by liquid scintillation spectrophotometry


Bioorg Med Chem 20: 2067-81 (2012)


Article DOI: 10.1016/j.bmc.2012.01.038
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50401046
PNG
(CHEMBL2206851)
Show SMILES CCCCCn1c(C)c(C(=O)c2cccc3cccc(I)c23)c2ccccc12
Show InChI InChI=1S/C25H24INO/c1-3-4-7-16-27-17(2)23(19-12-5-6-15-22(19)27)25(28)20-13-8-10-18-11-9-14-21(26)24(18)20/h5-6,8-15H,3-4,7,16H2,1-2H3
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13n/an/an/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB2 receptor expressed in CHO cells after 1 hr by liquid scintillation spectrophotometry


Bioorg Med Chem 20: 2067-81 (2012)


Article DOI: 10.1016/j.bmc.2012.01.038
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50401070
PNG
(CHEMBL2206856)
Show SMILES CCCCCn1c(C)c(C(=O)c2ccc(F)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C25H24FNO/c1-3-4-9-16-27-17(2)24(21-12-7-8-13-23(21)27)25(28)20-14-15-22(26)19-11-6-5-10-18(19)20/h5-8,10-15H,3-4,9,16H2,1-2H3
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14n/an/an/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB1 receptor expressed in HEK293 cells after 1 hr by liquid scintillation spectrophotometry


Bioorg Med Chem 20: 2067-81 (2012)


Article DOI: 10.1016/j.bmc.2012.01.038
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50401062
PNG
(CHEMBL2206835)
Show SMILES CCCCCn1c(C)c(C(=O)c2ccc(Br)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C25H24BrNO/c1-3-4-9-16-27-17(2)24(21-12-7-8-13-23(21)27)25(28)20-14-15-22(26)19-11-6-5-10-18(19)20/h5-8,10-15H,3-4,9,16H2,1-2H3
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14n/an/an/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB1 receptor expressed in HEK293 cells after 1 hr by liquid scintillation spectrophotometry


Bioorg Med Chem 20: 2067-81 (2012)


Article DOI: 10.1016/j.bmc.2012.01.038
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50401058
PNG
(CHEMBL2206839)
Show SMILES CCCCCn1c(C)c(C(=O)c2ccc(I)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C25H24INO/c1-3-4-9-16-27-17(2)24(21-12-7-8-13-23(21)27)25(28)20-14-15-22(26)19-11-6-5-10-18(19)20/h5-8,10-15H,3-4,9,16H2,1-2H3
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14n/an/an/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB1 receptor expressed in HEK293 cells after 1 hr by liquid scintillation spectrophotometry


Bioorg Med Chem 20: 2067-81 (2012)


Article DOI: 10.1016/j.bmc.2012.01.038
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50401054
PNG
(CHEMBL2206843)
Show SMILES CCCCCn1c(C)c(C(=O)c2cccc3cccc(Cl)c23)c2ccccc12
Show InChI InChI=1S/C25H24ClNO/c1-3-4-7-16-27-17(2)23(19-12-5-6-15-22(19)27)25(28)20-13-8-10-18-11-9-14-21(26)24(18)20/h5-6,8-15H,3-4,7,16H2,1-2H3
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19n/an/an/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB2 receptor expressed in CHO cells after 1 hr by liquid scintillation spectrophotometry


Bioorg Med Chem 20: 2067-81 (2012)


Article DOI: 10.1016/j.bmc.2012.01.038
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50401060
PNG
(CHEMBL2206837)
Show SMILES CCCn1c(C)c(C(=O)c2ccc(I)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C23H20INO/c1-3-14-25-15(2)22(19-10-6-7-11-21(19)25)23(26)18-12-13-20(24)17-9-5-4-8-16(17)18/h4-13H,3,14H2,1-2H3
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20n/an/an/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB2 receptor expressed in CHO cells after 1 hr by liquid scintillation spectrophotometry


Bioorg Med Chem 20: 2067-81 (2012)


Article DOI: 10.1016/j.bmc.2012.01.038
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50401051
PNG
(CHEMBL2206846)
Show SMILES CCCCCn1cc(C(=O)c2cccc3cccc(Br)c23)c2ccccc12
Show InChI InChI=1S/C24H22BrNO/c1-2-3-6-15-26-16-20(18-11-4-5-14-22(18)26)24(27)19-12-7-9-17-10-8-13-21(25)23(17)19/h4-5,7-14,16H,2-3,6,15H2,1H3
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21n/an/an/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB1 receptor expressed in HEK293 cells after 1 hr by liquid scintillation spectrophotometry


Bioorg Med Chem 20: 2067-81 (2012)


Article DOI: 10.1016/j.bmc.2012.01.038
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50401068
PNG
(CHEMBL2206858)
Show SMILES CCCn1c(C)c(C(=O)c2ccc(Cl)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C23H20ClNO/c1-3-14-25-15(2)22(19-10-6-7-11-21(19)25)23(26)18-12-13-20(24)17-9-5-4-8-16(17)18/h4-13H,3,14H2,1-2H3
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22n/an/an/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB2 receptor expressed in CHO cells after 1 hr by liquid scintillation spectrophotometry


Bioorg Med Chem 20: 2067-81 (2012)


Article DOI: 10.1016/j.bmc.2012.01.038
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50401055
PNG
(CHEMBL2206842)
Show SMILES CCCCCn1cc(C(=O)c2cccc3cccc(Cl)c23)c2ccccc12
Show InChI InChI=1S/C24H22ClNO/c1-2-3-6-15-26-16-20(18-11-4-5-14-22(18)26)24(27)19-12-7-9-17-10-8-13-21(25)23(17)19/h4-5,7-14,16H,2-3,6,15H2,1H3
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23n/an/an/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB1 receptor expressed in HEK293 cells after 1 hr by liquid scintillation spectrophotometry


Bioorg Med Chem 20: 2067-81 (2012)


Article DOI: 10.1016/j.bmc.2012.01.038
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50401065
PNG
(CHEMBL2206861)
Show SMILES CCCn1cc(C(=O)c2ccc(Br)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C22H18BrNO/c1-2-13-24-14-19(17-9-5-6-10-21(17)24)22(25)18-11-12-20(23)16-8-4-3-7-15(16)18/h3-12,14H,2,13H2,1H3
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27n/an/an/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB2 receptor expressed in CHO cells after 1 hr by liquid scintillation spectrophotometry


Bioorg Med Chem 20: 2067-81 (2012)


Article DOI: 10.1016/j.bmc.2012.01.038
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50401064
PNG
(CHEMBL2206833)
Show SMILES CCCn1c(C)c(C(=O)c2ccc(Br)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C23H20BrNO/c1-3-14-25-15(2)22(19-10-6-7-11-21(19)25)23(26)18-12-13-20(24)17-9-5-4-8-16(17)18/h4-13H,3,14H2,1-2H3
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31n/an/an/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB2 receptor expressed in CHO cells after 1 hr by liquid scintillation spectrophotometry


Bioorg Med Chem 20: 2067-81 (2012)


Article DOI: 10.1016/j.bmc.2012.01.038
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50401073
PNG
(CHEMBL2206853)
Show SMILES CCCn1cc(C(=O)c2ccc(F)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C22H18FNO/c1-2-13-24-14-19(17-9-5-6-10-21(17)24)22(25)18-11-12-20(23)16-8-4-3-7-15(16)18/h3-12,14H,2,13H2,1H3
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33n/an/an/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB2 receptor expressed in CHO cells after 1 hr by liquid scintillation spectrophotometry


Bioorg Med Chem 20: 2067-81 (2012)


Article DOI: 10.1016/j.bmc.2012.01.038
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM60994
PNG
((10R,10aR)-6,6,9-Trimethyl-3-pentyl-6a,7,8,10a-tet...)
Show SMILES CCCCCc1cc(O)c2[C@@H]3C=C(C)CC[C@H]3C(C)(C)Oc2c1 |r,t:11|
Show InChI InChI=1/C21H30O2/c1-5-6-7-8-15-12-18(22)20-16-11-14(2)9-10-17(16)21(3,4)23-19(20)13-15/h11-13,16-17,22H,5-10H2,1-4H3/t16-,17-/s2
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36n/an/an/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Binding affinity to human CB2 receptor by filtration assay


Bioorg Med Chem 20: 2067-81 (2012)


Article DOI: 10.1016/j.bmc.2012.01.038
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50401072
PNG
(CHEMBL2206854)
Show SMILES CCCn1c(C)c(C(=O)c2ccc(F)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C23H20FNO/c1-3-14-25-15(2)22(19-10-6-7-11-21(19)25)23(26)18-12-13-20(24)17-9-5-4-8-16(17)18/h4-13H,3,14H2,1-2H3
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38n/an/an/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB2 receptor expressed in CHO cells after 1 hr by liquid scintillation spectrophotometry


Bioorg Med Chem 20: 2067-81 (2012)


Article DOI: 10.1016/j.bmc.2012.01.038
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM60994
PNG
((10R,10aR)-6,6,9-Trimethyl-3-pentyl-6a,7,8,10a-tet...)
Show SMILES CCCCCc1cc(O)c2[C@@H]3C=C(C)CC[C@H]3C(C)(C)Oc2c1 |r,t:11|
Show InChI InChI=1/C21H30O2/c1-5-6-7-8-15-12-18(22)20-16-11-14(2)9-10-17(16)21(3,4)23-19(20)13-15/h11-13,16-17,22H,5-10H2,1-4H3/t16-,17-/s2
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41n/an/an/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from CB1 receptor


Bioorg Med Chem 20: 2067-81 (2012)


Article DOI: 10.1016/j.bmc.2012.01.038
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50401069
PNG
(CHEMBL2206857)
Show SMILES CCCn1cc(C(=O)c2ccc(Cl)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C22H18ClNO/c1-2-13-24-14-19(17-9-5-6-10-21(17)24)22(25)18-11-12-20(23)16-8-4-3-7-15(16)18/h3-12,14H,2,13H2,1H3
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44n/an/an/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB2 receptor expressed in CHO cells after 1 hr by liquid scintillation spectrophotometry


Bioorg Med Chem 20: 2067-81 (2012)


Article DOI: 10.1016/j.bmc.2012.01.038
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50401050
PNG
(CHEMBL2206847)
Show SMILES CCCCCn1c(C)c(C(=O)c2cccc3cccc(Br)c23)c2ccccc12
Show InChI InChI=1S/C25H24BrNO/c1-3-4-7-16-27-17(2)23(19-12-5-6-15-22(19)27)25(28)20-13-8-10-18-11-9-14-21(26)24(18)20/h5-6,8-15H,3-4,7,16H2,1-2H3
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54n/an/an/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB1 receptor expressed in HEK293 cells after 1 hr by liquid scintillation spectrophotometry


Bioorg Med Chem 20: 2067-81 (2012)


Article DOI: 10.1016/j.bmc.2012.01.038
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50401047
PNG
(CHEMBL2206850)
Show SMILES CCCCCn1cc(C(=O)c2cccc3cccc(I)c23)c2ccccc12
Show InChI InChI=1S/C24H22INO/c1-2-3-6-15-26-16-20(18-11-4-5-14-22(18)26)24(27)19-12-7-9-17-10-8-13-21(25)23(17)19/h4-5,7-14,16H,2-3,6,15H2,1H3
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73n/an/an/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB1 receptor expressed in HEK293 cells after 1 hr by liquid scintillation spectrophotometry


Bioorg Med Chem 20: 2067-81 (2012)


Article DOI: 10.1016/j.bmc.2012.01.038
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50401069
PNG
(CHEMBL2206857)
Show SMILES CCCn1cc(C(=O)c2ccc(Cl)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C22H18ClNO/c1-2-13-24-14-19(17-9-5-6-10-21(17)24)22(25)18-11-12-20(23)16-8-4-3-7-15(16)18/h3-12,14H,2,13H2,1H3
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93n/an/an/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB1 receptor expressed in HEK293 cells after 1 hr by liquid scintillation spectrophotometry


Bioorg Med Chem 20: 2067-81 (2012)


Article DOI: 10.1016/j.bmc.2012.01.038
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50401054
PNG
(CHEMBL2206843)
Show SMILES CCCCCn1c(C)c(C(=O)c2cccc3cccc(Cl)c23)c2ccccc12
Show InChI InChI=1S/C25H24ClNO/c1-3-4-7-16-27-17(2)23(19-12-5-6-15-22(19)27)25(28)20-13-8-10-18-11-9-14-21(26)24(18)20/h5-6,8-15H,3-4,7,16H2,1-2H3
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116n/an/an/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB1 receptor expressed in HEK293 cells after 1 hr by liquid scintillation spectrophotometry


Bioorg Med Chem 20: 2067-81 (2012)


Article DOI: 10.1016/j.bmc.2012.01.038
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50401057
PNG
(CHEMBL2206840)
Show SMILES CCCn1cc(C(=O)c2cccc3cccc(Cl)c23)c2ccccc12
Show InChI InChI=1S/C22H18ClNO/c1-2-13-24-14-18(16-9-3-4-12-20(16)24)22(25)17-10-5-7-15-8-6-11-19(23)21(15)17/h3-12,14H,2,13H2,1H3
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134n/an/an/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB2 receptor expressed in CHO cells after 1 hr by liquid scintillation spectrophotometry


Bioorg Med Chem 20: 2067-81 (2012)


Article DOI: 10.1016/j.bmc.2012.01.038
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50401061
PNG
(CHEMBL2206836)
Show SMILES CCCn1cc(C(=O)c2ccc(I)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C22H18INO/c1-2-13-24-14-19(17-9-5-6-10-21(17)24)22(25)18-11-12-20(23)16-8-4-3-7-15(16)18/h3-12,14H,2,13H2,1H3
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140n/an/an/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB1 receptor expressed in HEK293 cells after 1 hr by liquid scintillation spectrophotometry


Bioorg Med Chem 20: 2067-81 (2012)


Article DOI: 10.1016/j.bmc.2012.01.038
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50401049
PNG
(CHEMBL2206848)
Show SMILES CCCn1cc(C(=O)c2cccc3cccc(I)c23)c2ccccc12
Show InChI InChI=1S/C22H18INO/c1-2-13-24-14-18(16-9-3-4-12-20(16)24)22(25)17-10-5-7-15-8-6-11-19(23)21(15)17/h3-12,14H,2,13H2,1H3
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152n/an/an/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB2 receptor expressed in CHO cells after 1 hr by liquid scintillation spectrophotometry


Bioorg Med Chem 20: 2067-81 (2012)


Article DOI: 10.1016/j.bmc.2012.01.038
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50401065
PNG
(CHEMBL2206861)
Show SMILES CCCn1cc(C(=O)c2ccc(Br)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C22H18BrNO/c1-2-13-24-14-19(17-9-5-6-10-21(17)24)22(25)18-11-12-20(23)16-8-4-3-7-15(16)18/h3-12,14H,2,13H2,1H3
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161n/an/an/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB1 receptor expressed in HEK293 cells after 1 hr by liquid scintillation spectrophotometry


Bioorg Med Chem 20: 2067-81 (2012)


Article DOI: 10.1016/j.bmc.2012.01.038
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50401056
PNG
(CHEMBL2206841)
Show SMILES CCCn1c(C)c(C(=O)c2cccc3cccc(Cl)c23)c2ccccc12
Show InChI InChI=1S/C23H20ClNO/c1-3-14-25-15(2)21(17-10-4-5-13-20(17)25)23(26)18-11-6-8-16-9-7-12-19(24)22(16)18/h4-13H,3,14H2,1-2H3
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174n/an/an/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB2 receptor expressed in CHO cells after 1 hr by liquid scintillation spectrophotometry


Bioorg Med Chem 20: 2067-81 (2012)


Article DOI: 10.1016/j.bmc.2012.01.038
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50401068
PNG
(CHEMBL2206858)
Show SMILES CCCn1c(C)c(C(=O)c2ccc(Cl)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C23H20ClNO/c1-3-14-25-15(2)22(19-10-6-7-11-21(19)25)23(26)18-12-13-20(24)17-9-5-4-8-16(17)18/h4-13H,3,14H2,1-2H3
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187n/an/an/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB1 receptor expressed in HEK293 cells after 1 hr by liquid scintillation spectrophotometry


Bioorg Med Chem 20: 2067-81 (2012)


Article DOI: 10.1016/j.bmc.2012.01.038
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50401053
PNG
(CHEMBL2206844)
Show SMILES CCCn1cc(C(=O)c2cccc3cccc(Br)c23)c2ccccc12
Show InChI InChI=1S/C22H18BrNO/c1-2-13-24-14-18(16-9-3-4-12-20(16)24)22(25)17-10-5-7-15-8-6-11-19(23)21(15)17/h3-12,14H,2,13H2,1H3
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192n/an/an/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB2 receptor expressed in CHO cells after 1 hr by liquid scintillation spectrophotometry


Bioorg Med Chem 20: 2067-81 (2012)


Article DOI: 10.1016/j.bmc.2012.01.038
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50401073
PNG
(CHEMBL2206853)
Show SMILES CCCn1cc(C(=O)c2ccc(F)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C22H18FNO/c1-2-13-24-14-19(17-9-5-6-10-21(17)24)22(25)18-11-12-20(23)16-8-4-3-7-15(16)18/h3-12,14H,2,13H2,1H3
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240n/an/an/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB1 receptor expressed in HEK293 cells after 1 hr by liquid scintillation spectrophotometry


Bioorg Med Chem 20: 2067-81 (2012)


Article DOI: 10.1016/j.bmc.2012.01.038
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50401052
PNG
(CHEMBL2206845)
Show SMILES CCCn1c(C)c(C(=O)c2cccc3cccc(Br)c23)c2ccccc12
Show InChI InChI=1S/C23H20BrNO/c1-3-14-25-15(2)21(17-10-4-5-13-20(17)25)23(26)18-11-6-8-16-9-7-12-19(24)22(16)18/h4-13H,3,14H2,1-2H3
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278n/an/an/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB2 receptor expressed in CHO cells after 1 hr by liquid scintillation spectrophotometry


Bioorg Med Chem 20: 2067-81 (2012)


Article DOI: 10.1016/j.bmc.2012.01.038
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50401064
PNG
(CHEMBL2206833)
Show SMILES CCCn1c(C)c(C(=O)c2ccc(Br)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C23H20BrNO/c1-3-14-25-15(2)22(19-10-6-7-11-21(19)25)23(26)18-12-13-20(24)17-9-5-4-8-16(17)18/h4-13H,3,14H2,1-2H3
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373n/an/an/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB1 receptor expressed in HEK293 cells after 1 hr by liquid scintillation spectrophotometry


Bioorg Med Chem 20: 2067-81 (2012)


Article DOI: 10.1016/j.bmc.2012.01.038
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50401060
PNG
(CHEMBL2206837)
Show SMILES CCCn1c(C)c(C(=O)c2ccc(I)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C23H20INO/c1-3-14-25-15(2)22(19-10-6-7-11-21(19)25)23(26)18-12-13-20(24)17-9-5-4-8-16(17)18/h4-13H,3,14H2,1-2H3
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501n/an/an/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB1 receptor expressed in HEK293 cells after 1 hr by liquid scintillation spectrophotometry


Bioorg Med Chem 20: 2067-81 (2012)


Article DOI: 10.1016/j.bmc.2012.01.038
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50401046
PNG
(CHEMBL2206851)
Show SMILES CCCCCn1c(C)c(C(=O)c2cccc3cccc(I)c23)c2ccccc12
Show InChI InChI=1S/C25H24INO/c1-3-4-7-16-27-17(2)23(19-12-5-6-15-22(19)27)25(28)20-13-8-10-18-11-9-14-21(26)24(18)20/h5-6,8-15H,3-4,7,16H2,1-2H3
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522n/an/an/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB1 receptor expressed in HEK293 cells after 1 hr by liquid scintillation spectrophotometry


Bioorg Med Chem 20: 2067-81 (2012)


Article DOI: 10.1016/j.bmc.2012.01.038
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50401072
PNG
(CHEMBL2206854)
Show SMILES CCCn1c(C)c(C(=O)c2ccc(F)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C23H20FNO/c1-3-14-25-15(2)22(19-10-6-7-11-21(19)25)23(26)18-12-13-20(24)17-9-5-4-8-16(17)18/h4-13H,3,14H2,1-2H3
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530n/an/an/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB1 receptor expressed in HEK293 cells after 1 hr by liquid scintillation spectrophotometry


Bioorg Med Chem 20: 2067-81 (2012)


Article DOI: 10.1016/j.bmc.2012.01.038
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50401048
PNG
(CHEMBL2206849)
Show SMILES CCCn1c(C)c(C(=O)c2cccc3cccc(I)c23)c2ccccc12
Show InChI InChI=1S/C23H20INO/c1-3-14-25-15(2)21(17-10-4-5-13-20(17)25)23(26)18-11-6-8-16-9-7-12-19(24)22(16)18/h4-13H,3,14H2,1-2H3
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536n/an/an/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB2 receptor expressed in CHO cells after 1 hr by liquid scintillation spectrophotometry


Bioorg Med Chem 20: 2067-81 (2012)


Article DOI: 10.1016/j.bmc.2012.01.038
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50401057
PNG
(CHEMBL2206840)
Show SMILES CCCn1cc(C(=O)c2cccc3cccc(Cl)c23)c2ccccc12
Show InChI InChI=1S/C22H18ClNO/c1-2-13-24-14-18(16-9-3-4-12-20(16)24)22(25)17-10-5-7-15-8-6-11-19(23)21(15)17/h3-12,14H,2,13H2,1H3
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642n/an/an/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB1 receptor expressed in HEK293 cells after 1 hr by liquid scintillation spectrophotometry


Bioorg Med Chem 20: 2067-81 (2012)


Article DOI: 10.1016/j.bmc.2012.01.038
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50401049
PNG
(CHEMBL2206848)
Show SMILES CCCn1cc(C(=O)c2cccc3cccc(I)c23)c2ccccc12
Show InChI InChI=1S/C22H18INO/c1-2-13-24-14-18(16-9-3-4-12-20(16)24)22(25)17-10-5-7-15-8-6-11-19(23)21(15)17/h3-12,14H,2,13H2,1H3
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2.96E+3n/an/an/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB1 receptor expressed in HEK293 cells after 1 hr by liquid scintillation spectrophotometry


Bioorg Med Chem 20: 2067-81 (2012)


Article DOI: 10.1016/j.bmc.2012.01.038
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50401048
PNG
(CHEMBL2206849)
Show SMILES CCCn1c(C)c(C(=O)c2cccc3cccc(I)c23)c2ccccc12
Show InChI InChI=1S/C23H20INO/c1-3-14-25-15(2)21(17-10-4-5-13-20(17)25)23(26)18-11-6-8-16-9-7-12-19(24)22(16)18/h4-13H,3,14H2,1-2H3
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4.29E+3n/an/an/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB1 receptor expressed in HEK293 cells after 1 hr by liquid scintillation spectrophotometry


Bioorg Med Chem 20: 2067-81 (2012)


Article DOI: 10.1016/j.bmc.2012.01.038
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50401052
PNG
(CHEMBL2206845)
Show SMILES CCCn1c(C)c(C(=O)c2cccc3cccc(Br)c23)c2ccccc12
Show InChI InChI=1S/C23H20BrNO/c1-3-14-25-15(2)21(17-10-4-5-13-20(17)25)23(26)18-11-6-8-16-9-7-12-19(24)22(16)18/h4-13H,3,14H2,1-2H3
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>1.00E+4n/an/an/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB1 receptor expressed in HEK293 cells after 1 hr by liquid scintillation spectrophotometry


Bioorg Med Chem 20: 2067-81 (2012)


Article DOI: 10.1016/j.bmc.2012.01.038
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50401056
PNG
(CHEMBL2206841)
Show SMILES CCCn1c(C)c(C(=O)c2cccc3cccc(Cl)c23)c2ccccc12
Show InChI InChI=1S/C23H20ClNO/c1-3-14-25-15(2)21(17-10-4-5-13-20(17)25)23(26)18-11-6-8-16-9-7-12-19(24)22(16)18/h4-13H,3,14H2,1-2H3
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>1.00E+4n/an/an/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB1 receptor expressed in HEK293 cells after 1 hr by liquid scintillation spectrophotometry


Bioorg Med Chem 20: 2067-81 (2012)


Article DOI: 10.1016/j.bmc.2012.01.038
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50401053
PNG
(CHEMBL2206844)
Show SMILES CCCn1cc(C(=O)c2cccc3cccc(Br)c23)c2ccccc12
Show InChI InChI=1S/C22H18BrNO/c1-2-13-24-14-18(16-9-3-4-12-20(16)24)22(25)17-10-5-7-15-8-6-11-19(23)21(15)17/h3-12,14H,2,13H2,1H3
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>1.00E+4n/an/an/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55940 from human CB1 receptor expressed in HEK293 cells after 1 hr by liquid scintillation spectrophotometry


Bioorg Med Chem 20: 2067-81 (2012)


Article DOI: 10.1016/j.bmc.2012.01.038
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50401072
PNG
(CHEMBL2206854)
Show SMILES CCCn1c(C)c(C(=O)c2ccc(F)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C23H20FNO/c1-3-14-25-15(2)22(19-10-6-7-11-21(19)25)23(26)18-12-13-20(24)17-9-5-4-8-16(17)18/h4-13H,3,14H2,1-2H3
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n/an/an/an/a 2.68E+5n/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Activation of human CB1 receptor expressed in HEK293 cells assessed as [35S]GTPgamma binding after 90 mins by liquid scintillation spectrophotometry


Bioorg Med Chem 20: 2067-81 (2012)


Article DOI: 10.1016/j.bmc.2012.01.038
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%