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PubMed code 22361272

Compile data set for download or QSAR
Found 74 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM5446
PNG
(CHEMBL553 | ERLOTINIB HYDROCHLORIDE | Erlotinib | ...)
Show SMILES COCCOc1cc2ncnc(Nc3cccc(c3)C#C)c2cc1OCCOC
Show InChI InChI=1S/C22H23N3O4/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25)
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n/an/a 30n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant cytoplasmic domain of EGFR expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...

Bioorg Med Chem 20: 2010-8 (2012)


Article DOI: 10.1016/j.bmc.2012.01.051
BindingDB Entry DOI: 10.7270/Q27081WW
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))		BDBM5446
PNG
(CHEMBL553 | ERLOTINIB HYDROCHLORIDE | Erlotinib | ...)
Show SMILES COCCOc1cc2ncnc(Nc3cccc(c3)C#C)c2cc1OCCOC
Show InChI InChI=1S/C22H23N3O4/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25)
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n/an/a 140n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant cytoplasmic domain of HER2 expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...

Bioorg Med Chem 20: 2010-8 (2012)


Article DOI: 10.1016/j.bmc.2012.01.051
BindingDB Entry DOI: 10.7270/Q27081WW
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50365904
PNG
(CHEMBL1958215)
Show SMILES Cc1ccc(cc1)C1=NN(C(C1)c1ccc(Br)cc1)c1nc(O)cs1 |t:8|
Show InChI InChI=1S/C19H16BrN3OS/c1-12-2-4-13(5-3-12)16-10-17(14-6-8-15(20)9-7-14)23(22-16)19-21-18(24)11-25-19/h2-9,11,17,24H,10H2,1H3
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n/an/a 240n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant cytoplasmic domain of EGFR expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...

Bioorg Med Chem 20: 2010-8 (2012)


Article DOI: 10.1016/j.bmc.2012.01.051
BindingDB Entry DOI: 10.7270/Q27081WW
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))		BDBM50365904
PNG
(CHEMBL1958215)
Show SMILES Cc1ccc(cc1)C1=NN(C(C1)c1ccc(Br)cc1)c1nc(O)cs1 |t:8|
Show InChI InChI=1S/C19H16BrN3OS/c1-12-2-4-13(5-3-12)16-10-17(14-6-8-15(20)9-7-14)23(22-16)19-21-18(24)11-25-19/h2-9,11,17,24H,10H2,1H3
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n/an/a 1.07E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant cytoplasmic domain of HER2 expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...

Bioorg Med Chem 20: 2010-8 (2012)


Article DOI: 10.1016/j.bmc.2012.01.051
BindingDB Entry DOI: 10.7270/Q27081WW
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50365937
PNG
(CHEMBL1958212)
Show SMILES Cc1ccc(cc1)C1=NN(C(C1)c1ccccc1)c1nc(O)cs1 |t:8|
Show InChI InChI=1S/C19H17N3OS/c1-13-7-9-14(10-8-13)16-11-17(15-5-3-2-4-6-15)22(21-16)19-20-18(23)12-24-19/h2-10,12,17,23H,11H2,1H3
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n/an/a 1.08E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant cytoplasmic domain of EGFR expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...

Bioorg Med Chem 20: 2010-8 (2012)


Article DOI: 10.1016/j.bmc.2012.01.051
BindingDB Entry DOI: 10.7270/Q27081WW
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50365905
PNG
(CHEMBL1958216)
Show SMILES Cc1ccc(cc1)C1CC(=NN1c1nc(O)cs1)c1ccc(C)cc1 |c:10|
Show InChI InChI=1S/C20H19N3OS/c1-13-3-7-15(8-4-13)17-11-18(16-9-5-14(2)6-10-16)23(22-17)20-21-19(24)12-25-20/h3-10,12,18,24H,11H2,1-2H3
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n/an/a 1.16E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant cytoplasmic domain of EGFR expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...

Bioorg Med Chem 20: 2010-8 (2012)


Article DOI: 10.1016/j.bmc.2012.01.051
BindingDB Entry DOI: 10.7270/Q27081WW
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50365910
PNG
(CHEMBL1958221)
Show SMILES COc1ccc(cc1)C1=NN(C(C1)c1ccc(Br)cc1)c1nc(O)cs1 |t:9|
Show InChI InChI=1S/C19H16BrN3O2S/c1-25-15-8-4-12(5-9-15)16-10-17(13-2-6-14(20)7-3-13)23(22-16)19-21-18(24)11-26-19/h2-9,11,17,24H,10H2,1H3
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n/an/a 1.26E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant cytoplasmic domain of EGFR expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...

Bioorg Med Chem 20: 2010-8 (2012)


Article DOI: 10.1016/j.bmc.2012.01.051
BindingDB Entry DOI: 10.7270/Q27081WW
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50365916
PNG
(CHEMBL1958022)
Show SMILES Oc1csc(n1)N1N=C(CC1c1ccc(Br)cc1)c1ccccc1 |c:8|
Show InChI InChI=1S/C18H14BrN3OS/c19-14-8-6-13(7-9-14)16-10-15(12-4-2-1-3-5-12)21-22(16)18-20-17(23)11-24-18/h1-9,11,16,23H,10H2
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n/an/a 1.35E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant cytoplasmic domain of EGFR expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...

Bioorg Med Chem 20: 2010-8 (2012)


Article DOI: 10.1016/j.bmc.2012.01.051
BindingDB Entry DOI: 10.7270/Q27081WW
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50365903
PNG
(CHEMBL1958214)
Show SMILES Cc1ccc(cc1)C1=NN(C(C1)c1ccc(Cl)cc1)c1nc(O)cs1 |t:8|
Show InChI InChI=1S/C19H16ClN3OS/c1-12-2-4-13(5-3-12)16-10-17(14-6-8-15(20)9-7-14)23(22-16)19-21-18(24)11-25-19/h2-9,11,17,24H,10H2,1H3
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n/an/a 1.66E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant cytoplasmic domain of EGFR expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...

Bioorg Med Chem 20: 2010-8 (2012)


Article DOI: 10.1016/j.bmc.2012.01.051
BindingDB Entry DOI: 10.7270/Q27081WW
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50365902
PNG
(CHEMBL1958213)
Show SMILES Cc1ccc(cc1)C1=NN(C(C1)c1ccc(F)cc1)c1nc(O)cs1 |t:8|
Show InChI InChI=1S/C19H16FN3OS/c1-12-2-4-13(5-3-12)16-10-17(14-6-8-15(20)9-7-14)23(22-16)19-21-18(24)11-25-19/h2-9,11,17,24H,10H2,1H3
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n/an/a 2.01E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant cytoplasmic domain of EGFR expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...

Bioorg Med Chem 20: 2010-8 (2012)


Article DOI: 10.1016/j.bmc.2012.01.051
BindingDB Entry DOI: 10.7270/Q27081WW
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50365934
PNG
(CHEMBL1958209)
Show SMILES Oc1csc(n1)N1N=C(CC1c1ccc(Br)cc1)c1ccc(Br)cc1 |c:8|
Show InChI InChI=1S/C18H13Br2N3OS/c19-13-5-1-11(2-6-13)15-9-16(12-3-7-14(20)8-4-12)23(22-15)18-21-17(24)10-25-18/h1-8,10,16,24H,9H2
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n/an/a 2.03E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant cytoplasmic domain of EGFR expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...

Bioorg Med Chem 20: 2010-8 (2012)


Article DOI: 10.1016/j.bmc.2012.01.051
BindingDB Entry DOI: 10.7270/Q27081WW
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))		BDBM50365937
PNG
(CHEMBL1958212)
Show SMILES Cc1ccc(cc1)C1=NN(C(C1)c1ccccc1)c1nc(O)cs1 |t:8|
Show InChI InChI=1S/C19H17N3OS/c1-13-7-9-14(10-8-13)16-11-17(15-5-3-2-4-6-15)22(21-16)19-20-18(23)12-24-19/h2-10,12,17,23H,11H2,1H3
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n/an/a 2.24E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant cytoplasmic domain of HER2 expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...

Bioorg Med Chem 20: 2010-8 (2012)


Article DOI: 10.1016/j.bmc.2012.01.051
BindingDB Entry DOI: 10.7270/Q27081WW
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50365928
PNG
(CHEMBL1958034)
Show SMILES Oc1csc(n1)N1N=C(CC1c1ccc(Br)cc1)c1ccc(Cl)cc1 |c:8|
Show InChI InChI=1S/C18H13BrClN3OS/c19-13-5-1-12(2-6-13)16-9-15(11-3-7-14(20)8-4-11)22-23(16)18-21-17(24)10-25-18/h1-8,10,16,24H,9H2
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n/an/a 2.28E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant cytoplasmic domain of EGFR expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...

Bioorg Med Chem 20: 2010-8 (2012)


Article DOI: 10.1016/j.bmc.2012.01.051
BindingDB Entry DOI: 10.7270/Q27081WW
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50365907
PNG
(CHEMBL1958218)
Show SMILES COc1ccc(cc1)C1=NN(C(C1)c1ccccc1)c1nc(O)cs1 |t:9|
Show InChI InChI=1S/C19H17N3O2S/c1-24-15-9-7-13(8-10-15)16-11-17(14-5-3-2-4-6-14)22(21-16)19-20-18(23)12-25-19/h2-10,12,17,23H,11H2,1H3
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n/an/a 2.37E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant cytoplasmic domain of EGFR expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...

Bioorg Med Chem 20: 2010-8 (2012)


Article DOI: 10.1016/j.bmc.2012.01.051
BindingDB Entry DOI: 10.7270/Q27081WW
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))		BDBM50365905
PNG
(CHEMBL1958216)
Show SMILES Cc1ccc(cc1)C1CC(=NN1c1nc(O)cs1)c1ccc(C)cc1 |c:10|
Show InChI InChI=1S/C20H19N3OS/c1-13-3-7-15(8-4-13)17-11-18(16-9-5-14(2)6-10-16)23(22-17)20-21-19(24)12-25-20/h3-10,12,18,24H,11H2,1-2H3
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n/an/a 2.52E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant cytoplasmic domain of HER2 expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...

Bioorg Med Chem 20: 2010-8 (2012)


Article DOI: 10.1016/j.bmc.2012.01.051
BindingDB Entry DOI: 10.7270/Q27081WW
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))		BDBM50365910
PNG
(CHEMBL1958221)
Show SMILES COc1ccc(cc1)C1=NN(C(C1)c1ccc(Br)cc1)c1nc(O)cs1 |t:9|
Show InChI InChI=1S/C19H16BrN3O2S/c1-25-15-8-4-12(5-9-15)16-10-17(13-2-6-14(20)7-3-13)23(22-16)19-21-18(24)11-26-19/h2-9,11,17,24H,10H2,1H3
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n/an/a 2.75E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant cytoplasmic domain of HER2 expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...

Bioorg Med Chem 20: 2010-8 (2012)


Article DOI: 10.1016/j.bmc.2012.01.051
BindingDB Entry DOI: 10.7270/Q27081WW
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50365917
PNG
(CHEMBL1958023)
Show SMILES Cc1ccc(cc1)C1CC(=NN1c1nc(O)cs1)c1ccccc1 |c:10|
Show InChI InChI=1S/C19H17N3OS/c1-13-7-9-15(10-8-13)17-11-16(14-5-3-2-4-6-14)21-22(17)19-20-18(23)12-24-19/h2-10,12,17,23H,11H2,1H3
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n/an/a 3.03E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant cytoplasmic domain of EGFR expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...

Bioorg Med Chem 20: 2010-8 (2012)


Article DOI: 10.1016/j.bmc.2012.01.051
BindingDB Entry DOI: 10.7270/Q27081WW
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))		BDBM50365916
PNG
(CHEMBL1958022)
Show SMILES Oc1csc(n1)N1N=C(CC1c1ccc(Br)cc1)c1ccccc1 |c:8|
Show InChI InChI=1S/C18H14BrN3OS/c19-14-8-6-13(7-9-14)16-10-15(12-4-2-1-3-5-12)21-22(16)18-20-17(23)11-24-18/h1-9,11,16,23H,10H2
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n/an/a 3.05E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant cytoplasmic domain of HER2 expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...

Bioorg Med Chem 20: 2010-8 (2012)


Article DOI: 10.1016/j.bmc.2012.01.051
BindingDB Entry DOI: 10.7270/Q27081WW
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))		BDBM50365903
PNG
(CHEMBL1958214)
Show SMILES Cc1ccc(cc1)C1=NN(C(C1)c1ccc(Cl)cc1)c1nc(O)cs1 |t:8|
Show InChI InChI=1S/C19H16ClN3OS/c1-12-2-4-13(5-3-12)16-10-17(14-6-8-15(20)9-7-14)23(22-16)19-21-18(24)11-25-19/h2-9,11,17,24H,10H2,1H3
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n/an/a 3.11E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant cytoplasmic domain of HER2 expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...

Bioorg Med Chem 20: 2010-8 (2012)


Article DOI: 10.1016/j.bmc.2012.01.051
BindingDB Entry DOI: 10.7270/Q27081WW
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50365931
PNG
(CHEMBL1958037)
Show SMILES Oc1csc(n1)N1N=C(CC1c1ccccc1)c1ccc(Br)cc1 |c:8|
Show InChI InChI=1S/C18H14BrN3OS/c19-14-8-6-12(7-9-14)15-10-16(13-4-2-1-3-5-13)22(21-15)18-20-17(23)11-24-18/h1-9,11,16,23H,10H2
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n/an/a 3.20E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant cytoplasmic domain of EGFR expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...

Bioorg Med Chem 20: 2010-8 (2012)


Article DOI: 10.1016/j.bmc.2012.01.051
BindingDB Entry DOI: 10.7270/Q27081WW
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50365913
PNG
(CHEMBL1958019)
Show SMILES Oc1csc(n1)N1N=C(CC1c1ccccc1)c1ccccc1 |c:8|
Show InChI InChI=1S/C18H15N3OS/c22-17-12-23-18(19-17)21-16(14-9-5-2-6-10-14)11-15(20-21)13-7-3-1-4-8-13/h1-10,12,16,22H,11H2
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n/an/a 3.38E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant cytoplasmic domain of EGFR expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...

Bioorg Med Chem 20: 2010-8 (2012)


Article DOI: 10.1016/j.bmc.2012.01.051
BindingDB Entry DOI: 10.7270/Q27081WW
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50365915
PNG
(CHEMBL1958021)
Show SMILES Oc1csc(n1)N1N=C(CC1c1ccc(Cl)cc1)c1ccccc1 |c:8|
Show InChI InChI=1S/C18H14ClN3OS/c19-14-8-6-13(7-9-14)16-10-15(12-4-2-1-3-5-12)21-22(16)18-20-17(23)11-24-18/h1-9,11,16,23H,10H2
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n/an/a 3.49E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant cytoplasmic domain of EGFR expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...

Bioorg Med Chem 20: 2010-8 (2012)


Article DOI: 10.1016/j.bmc.2012.01.051
BindingDB Entry DOI: 10.7270/Q27081WW
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))		BDBM50365902
PNG
(CHEMBL1958213)
Show SMILES Cc1ccc(cc1)C1=NN(C(C1)c1ccc(F)cc1)c1nc(O)cs1 |t:8|
Show InChI InChI=1S/C19H16FN3OS/c1-12-2-4-13(5-3-12)16-10-17(14-6-8-15(20)9-7-14)23(22-16)19-21-18(24)11-25-19/h2-9,11,17,24H,10H2,1H3
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n/an/a 3.53E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant cytoplasmic domain of HER2 expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...

Bioorg Med Chem 20: 2010-8 (2012)


Article DOI: 10.1016/j.bmc.2012.01.051
BindingDB Entry DOI: 10.7270/Q27081WW
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))		BDBM50365934
PNG
(CHEMBL1958209)
Show SMILES Oc1csc(n1)N1N=C(CC1c1ccc(Br)cc1)c1ccc(Br)cc1 |c:8|
Show InChI InChI=1S/C18H13Br2N3OS/c19-13-5-1-11(2-6-13)15-9-16(12-3-7-14(20)8-4-12)23(22-15)18-21-17(24)10-25-18/h1-8,10,16,24H,9H2
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n/an/a 3.65E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant cytoplasmic domain of HER2 expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...

Bioorg Med Chem 20: 2010-8 (2012)


Article DOI: 10.1016/j.bmc.2012.01.051
BindingDB Entry DOI: 10.7270/Q27081WW
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))		BDBM50365928
PNG
(CHEMBL1958034)
Show SMILES Oc1csc(n1)N1N=C(CC1c1ccc(Br)cc1)c1ccc(Cl)cc1 |c:8|
Show InChI InChI=1S/C18H13BrClN3OS/c19-13-5-1-12(2-6-13)16-9-15(11-3-7-14(20)8-4-11)22-23(16)18-21-17(24)10-25-18/h1-8,10,16,24H,9H2
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n/an/a 3.84E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant cytoplasmic domain of HER2 expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...

Bioorg Med Chem 20: 2010-8 (2012)


Article DOI: 10.1016/j.bmc.2012.01.051
BindingDB Entry DOI: 10.7270/Q27081WW
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50365933
PNG
(CHEMBL1958039)
Show SMILES Oc1csc(n1)N1N=C(CC1c1ccc(Cl)cc1)c1ccc(Br)cc1 |c:8|
Show InChI InChI=1S/C18H13BrClN3OS/c19-13-5-1-11(2-6-13)15-9-16(12-3-7-14(20)8-4-12)23(22-15)18-21-17(24)10-25-18/h1-8,10,16,24H,9H2
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n/an/a 4.12E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant cytoplasmic domain of EGFR expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...

Bioorg Med Chem 20: 2010-8 (2012)


Article DOI: 10.1016/j.bmc.2012.01.051
BindingDB Entry DOI: 10.7270/Q27081WW
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))		BDBM50365907
PNG
(CHEMBL1958218)
Show SMILES COc1ccc(cc1)C1=NN(C(C1)c1ccccc1)c1nc(O)cs1 |t:9|
Show InChI InChI=1S/C19H17N3O2S/c1-24-15-9-7-13(8-10-15)16-11-17(14-5-3-2-4-6-14)22(21-16)19-20-18(23)12-25-19/h2-10,12,17,23H,11H2,1H3
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n/an/a 4.12E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant cytoplasmic domain of HER2 expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...

Bioorg Med Chem 20: 2010-8 (2012)


Article DOI: 10.1016/j.bmc.2012.01.051
BindingDB Entry DOI: 10.7270/Q27081WW
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50365906
PNG
(CHEMBL1958217)
Show SMILES COc1ccc(cc1)C1CC(=NN1c1nc(O)cs1)c1ccc(C)cc1 |c:11|
Show InChI InChI=1S/C20H19N3O2S/c1-13-3-5-14(6-4-13)17-11-18(15-7-9-16(25-2)10-8-15)23(22-17)20-21-19(24)12-26-20/h3-10,12,18,24H,11H2,1-2H3
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n/an/a 4.24E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant cytoplasmic domain of EGFR expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...

Bioorg Med Chem 20: 2010-8 (2012)


Article DOI: 10.1016/j.bmc.2012.01.051
BindingDB Entry DOI: 10.7270/Q27081WW
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50365918
PNG
(CHEMBL1958024)
Show SMILES COc1ccc(cc1)C1CC(=NN1c1nc(O)cs1)c1ccccc1 |c:11|
Show InChI InChI=1S/C19H17N3O2S/c1-24-15-9-7-14(8-10-15)17-11-16(13-5-3-2-4-6-13)21-22(17)19-20-18(23)12-25-19/h2-10,12,17,23H,11H2,1H3
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n/an/a 4.27E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant cytoplasmic domain of EGFR expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...

Bioorg Med Chem 20: 2010-8 (2012)


Article DOI: 10.1016/j.bmc.2012.01.051
BindingDB Entry DOI: 10.7270/Q27081WW
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))		BDBM50365917
PNG
(CHEMBL1958023)
Show SMILES Cc1ccc(cc1)C1CC(=NN1c1nc(O)cs1)c1ccccc1 |c:10|
Show InChI InChI=1S/C19H17N3OS/c1-13-7-9-15(10-8-13)17-11-16(14-5-3-2-4-6-14)21-22(17)19-20-18(23)12-24-19/h2-10,12,17,23H,11H2,1H3
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n/an/a 4.64E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant cytoplasmic domain of HER2 expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...

Bioorg Med Chem 20: 2010-8 (2012)


Article DOI: 10.1016/j.bmc.2012.01.051
BindingDB Entry DOI: 10.7270/Q27081WW
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50365922
PNG
(CHEMBL1958028)
Show SMILES Oc1csc(n1)N1N=C(CC1c1ccc(Br)cc1)c1ccc(F)cc1 |c:8|
Show InChI InChI=1S/C18H13BrFN3OS/c19-13-5-1-12(2-6-13)16-9-15(11-3-7-14(20)8-4-11)22-23(16)18-21-17(24)10-25-18/h1-8,10,16,24H,9H2
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n/an/a 4.79E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant cytoplasmic domain of EGFR expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...

Bioorg Med Chem 20: 2010-8 (2012)


Article DOI: 10.1016/j.bmc.2012.01.051
BindingDB Entry DOI: 10.7270/Q27081WW
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))		BDBM50365915
PNG
(CHEMBL1958021)
Show SMILES Oc1csc(n1)N1N=C(CC1c1ccc(Cl)cc1)c1ccccc1 |c:8|
Show InChI InChI=1S/C18H14ClN3OS/c19-14-8-6-13(7-9-14)16-10-15(12-4-2-1-3-5-12)21-22(16)18-20-17(23)11-24-18/h1-9,11,16,23H,10H2
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n/an/a 4.83E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant cytoplasmic domain of HER2 expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...

Bioorg Med Chem 20: 2010-8 (2012)


Article DOI: 10.1016/j.bmc.2012.01.051
BindingDB Entry DOI: 10.7270/Q27081WW
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50365914
PNG
(CHEMBL1958020)
Show SMILES Oc1csc(n1)N1N=C(CC1c1ccc(F)cc1)c1ccccc1 |c:8|
Show InChI InChI=1S/C18H14FN3OS/c19-14-8-6-13(7-9-14)16-10-15(12-4-2-1-3-5-12)21-22(16)18-20-17(23)11-24-18/h1-9,11,16,23H,10H2
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n/an/a 4.86E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant cytoplasmic domain of EGFR expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...

Bioorg Med Chem 20: 2010-8 (2012)


Article DOI: 10.1016/j.bmc.2012.01.051
BindingDB Entry DOI: 10.7270/Q27081WW
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))		BDBM50365931
PNG
(CHEMBL1958037)
Show SMILES Oc1csc(n1)N1N=C(CC1c1ccccc1)c1ccc(Br)cc1 |c:8|
Show InChI InChI=1S/C18H14BrN3OS/c19-14-8-6-12(7-9-14)15-10-16(13-4-2-1-3-5-13)22(21-15)18-20-17(23)11-24-18/h1-9,11,16,23H,10H2
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n/an/a 4.87E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant cytoplasmic domain of HER2 expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...

Bioorg Med Chem 20: 2010-8 (2012)


Article DOI: 10.1016/j.bmc.2012.01.051
BindingDB Entry DOI: 10.7270/Q27081WW
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))		BDBM50365913
PNG
(CHEMBL1958019)
Show SMILES Oc1csc(n1)N1N=C(CC1c1ccccc1)c1ccccc1 |c:8|
Show InChI InChI=1S/C18H15N3OS/c22-17-12-23-18(19-17)21-16(14-9-5-2-6-10-14)11-15(20-21)13-7-3-1-4-8-13/h1-10,12,16,22H,11H2
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n/an/a 5.12E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant cytoplasmic domain of HER2 expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...

Bioorg Med Chem 20: 2010-8 (2012)


Article DOI: 10.1016/j.bmc.2012.01.051
BindingDB Entry DOI: 10.7270/Q27081WW
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50365925
PNG
(CHEMBL1958031)
Show SMILES Oc1csc(n1)N1N=C(CC1c1ccccc1)c1ccc(Cl)cc1 |c:8|
Show InChI InChI=1S/C18H14ClN3OS/c19-14-8-6-12(7-9-14)15-10-16(13-4-2-1-3-5-13)22(21-15)18-20-17(23)11-24-18/h1-9,11,16,23H,10H2
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n/an/a 5.34E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant cytoplasmic domain of EGFR expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...

Bioorg Med Chem 20: 2010-8 (2012)


Article DOI: 10.1016/j.bmc.2012.01.051
BindingDB Entry DOI: 10.7270/Q27081WW
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50365909
PNG
(CHEMBL1958220)
Show SMILES COc1ccc(cc1)C1=NN(C(C1)c1ccc(Cl)cc1)c1nc(O)cs1 |t:9|
Show InChI InChI=1S/C19H16ClN3O2S/c1-25-15-8-4-12(5-9-15)16-10-17(13-2-6-14(20)7-3-13)23(22-16)19-21-18(24)11-26-19/h2-9,11,17,24H,10H2,1H3
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n/an/a 5.35E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant cytoplasmic domain of EGFR expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...

Bioorg Med Chem 20: 2010-8 (2012)


Article DOI: 10.1016/j.bmc.2012.01.051
BindingDB Entry DOI: 10.7270/Q27081WW
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50365911
PNG
(CHEMBL1958222)
Show SMILES COc1ccc(cc1)C1=NN(C(C1)c1ccc(C)cc1)c1nc(O)cs1 |t:9|
Show InChI InChI=1S/C20H19N3O2S/c1-13-3-5-15(6-4-13)18-11-17(14-7-9-16(25-2)10-8-14)22-23(18)20-21-19(24)12-26-20/h3-10,12,18,24H,11H2,1-2H3
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n/an/a 5.46E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant cytoplasmic domain of EGFR expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...

Bioorg Med Chem 20: 2010-8 (2012)


Article DOI: 10.1016/j.bmc.2012.01.051
BindingDB Entry DOI: 10.7270/Q27081WW
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50365935
PNG
(CHEMBL1958210)
Show SMILES Cc1ccc(cc1)C1CC(=NN1c1nc(O)cs1)c1ccc(Br)cc1 |c:10|
Show InChI InChI=1S/C19H16BrN3OS/c1-12-2-4-14(5-3-12)17-10-16(13-6-8-15(20)9-7-13)22-23(17)19-21-18(24)11-25-19/h2-9,11,17,24H,10H2,1H3
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n/an/a 5.58E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant cytoplasmic domain of EGFR expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...

Bioorg Med Chem 20: 2010-8 (2012)


Article DOI: 10.1016/j.bmc.2012.01.051
BindingDB Entry DOI: 10.7270/Q27081WW
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))		BDBM50365933
PNG
(CHEMBL1958039)
Show SMILES Oc1csc(n1)N1N=C(CC1c1ccc(Cl)cc1)c1ccc(Br)cc1 |c:8|
Show InChI InChI=1S/C18H13BrClN3OS/c19-13-5-1-11(2-6-13)15-9-16(12-3-7-14(20)8-4-12)23(22-15)18-21-17(24)10-25-18/h1-8,10,16,24H,9H2
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n/an/a 5.87E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant cytoplasmic domain of HER2 expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...

Bioorg Med Chem 20: 2010-8 (2012)


Article DOI: 10.1016/j.bmc.2012.01.051
BindingDB Entry DOI: 10.7270/Q27081WW
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50365908
PNG
(CHEMBL1958219)
Show SMILES COc1ccc(cc1)C1=NN(C(C1)c1ccc(F)cc1)c1nc(O)cs1 |t:9|
Show InChI InChI=1S/C19H16FN3O2S/c1-25-15-8-4-12(5-9-15)16-10-17(13-2-6-14(20)7-3-13)23(22-16)19-21-18(24)11-26-19/h2-9,11,17,24H,10H2,1H3
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n/an/a 5.95E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant cytoplasmic domain of EGFR expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...

Bioorg Med Chem 20: 2010-8 (2012)


Article DOI: 10.1016/j.bmc.2012.01.051
BindingDB Entry DOI: 10.7270/Q27081WW
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))		BDBM50365918
PNG
(CHEMBL1958024)
Show SMILES COc1ccc(cc1)C1CC(=NN1c1nc(O)cs1)c1ccccc1 |c:11|
Show InChI InChI=1S/C19H17N3O2S/c1-24-15-9-7-14(8-10-15)17-11-16(13-5-3-2-4-6-13)21-22(17)19-20-18(23)12-25-19/h2-10,12,17,23H,11H2,1H3
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n/an/a 6.21E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant cytoplasmic domain of HER2 expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...

Bioorg Med Chem 20: 2010-8 (2012)


Article DOI: 10.1016/j.bmc.2012.01.051
BindingDB Entry DOI: 10.7270/Q27081WW
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))		BDBM50365906
PNG
(CHEMBL1958217)
Show SMILES COc1ccc(cc1)C1CC(=NN1c1nc(O)cs1)c1ccc(C)cc1 |c:11|
Show InChI InChI=1S/C20H19N3O2S/c1-13-3-5-14(6-4-13)17-11-18(15-7-9-16(25-2)10-8-15)23(22-17)20-21-19(24)12-26-20/h3-10,12,18,24H,11H2,1-2H3
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n/an/a 6.23E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant cytoplasmic domain of HER2 expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...

Bioorg Med Chem 20: 2010-8 (2012)


Article DOI: 10.1016/j.bmc.2012.01.051
BindingDB Entry DOI: 10.7270/Q27081WW
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))		BDBM50365922
PNG
(CHEMBL1958028)
Show SMILES Oc1csc(n1)N1N=C(CC1c1ccc(Br)cc1)c1ccc(F)cc1 |c:8|
Show InChI InChI=1S/C18H13BrFN3OS/c19-13-5-1-12(2-6-13)16-9-15(11-3-7-14(20)8-4-11)22-23(16)18-21-17(24)10-25-18/h1-8,10,16,24H,9H2
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n/an/a 6.24E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant cytoplasmic domain of HER2 expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...

Bioorg Med Chem 20: 2010-8 (2012)


Article DOI: 10.1016/j.bmc.2012.01.051
BindingDB Entry DOI: 10.7270/Q27081WW
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))		BDBM50365914
PNG
(CHEMBL1958020)
Show SMILES Oc1csc(n1)N1N=C(CC1c1ccc(F)cc1)c1ccccc1 |c:8|
Show InChI InChI=1S/C18H14FN3OS/c19-14-8-6-13(7-9-14)16-10-15(12-4-2-1-3-5-12)21-22(16)18-20-17(23)11-24-18/h1-9,11,16,23H,10H2
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n/an/a 6.35E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant cytoplasmic domain of HER2 expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...

Bioorg Med Chem 20: 2010-8 (2012)


Article DOI: 10.1016/j.bmc.2012.01.051
BindingDB Entry DOI: 10.7270/Q27081WW
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50365932
PNG
(CHEMBL1958038)
Show SMILES Oc1csc(n1)N1N=C(CC1c1ccc(F)cc1)c1ccc(Br)cc1 |c:8|
Show InChI InChI=1S/C18H13BrFN3OS/c19-13-5-1-11(2-6-13)15-9-16(12-3-7-14(20)8-4-12)23(22-15)18-21-17(24)10-25-18/h1-8,10,16,24H,9H2
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n/an/a 6.48E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant cytoplasmic domain of EGFR expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...

Bioorg Med Chem 20: 2010-8 (2012)


Article DOI: 10.1016/j.bmc.2012.01.051
BindingDB Entry DOI: 10.7270/Q27081WW
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50365929
PNG
(CHEMBL1958035)
Show SMILES Cc1ccc(cc1)C1CC(=NN1c1nc(O)cs1)c1ccc(Cl)cc1 |c:10|
Show InChI InChI=1S/C19H16ClN3OS/c1-12-2-4-14(5-3-12)17-10-16(13-6-8-15(20)9-7-13)22-23(17)19-21-18(24)11-25-19/h2-9,11,17,24H,10H2,1H3
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n/an/a 6.67E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant cytoplasmic domain of EGFR expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...

Bioorg Med Chem 20: 2010-8 (2012)


Article DOI: 10.1016/j.bmc.2012.01.051
BindingDB Entry DOI: 10.7270/Q27081WW
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))		BDBM50365935
PNG
(CHEMBL1958210)
Show SMILES Cc1ccc(cc1)C1CC(=NN1c1nc(O)cs1)c1ccc(Br)cc1 |c:10|
Show InChI InChI=1S/C19H16BrN3OS/c1-12-2-4-14(5-3-12)17-10-16(13-6-8-15(20)9-7-13)22-23(17)19-21-18(24)11-25-19/h2-9,11,17,24H,10H2,1H3
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n/an/a 7.04E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant cytoplasmic domain of HER2 expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...

Bioorg Med Chem 20: 2010-8 (2012)


Article DOI: 10.1016/j.bmc.2012.01.051
BindingDB Entry DOI: 10.7270/Q27081WW
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))		BDBM50365925
PNG
(CHEMBL1958031)
Show SMILES Oc1csc(n1)N1N=C(CC1c1ccccc1)c1ccc(Cl)cc1 |c:8|
Show InChI InChI=1S/C18H14ClN3OS/c19-14-8-6-12(7-9-14)15-10-16(13-4-2-1-3-5-13)22(21-15)18-20-17(23)11-24-18/h1-9,11,16,23H,10H2
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n/an/a 7.05E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant cytoplasmic domain of HER2 expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...

Bioorg Med Chem 20: 2010-8 (2012)


Article DOI: 10.1016/j.bmc.2012.01.051
BindingDB Entry DOI: 10.7270/Q27081WW
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))		BDBM50365911
PNG
(CHEMBL1958222)
Show SMILES COc1ccc(cc1)C1=NN(C(C1)c1ccc(C)cc1)c1nc(O)cs1 |t:9|
Show InChI InChI=1S/C20H19N3O2S/c1-13-3-5-15(6-4-13)18-11-17(14-7-9-16(25-2)10-8-14)22-23(18)20-21-19(24)12-26-20/h3-10,12,18,24H,11H2,1-2H3
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n/an/a 7.35E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant cytoplasmic domain of HER2 expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...

Bioorg Med Chem 20: 2010-8 (2012)


Article DOI: 10.1016/j.bmc.2012.01.051
BindingDB Entry DOI: 10.7270/Q27081WW
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))		BDBM50365909
PNG
(CHEMBL1958220)
Show SMILES COc1ccc(cc1)C1=NN(C(C1)c1ccc(Cl)cc1)c1nc(O)cs1 |t:9|
Show InChI InChI=1S/C19H16ClN3O2S/c1-25-15-8-4-12(5-9-15)16-10-17(13-2-6-14(20)7-3-13)23(22-16)19-21-18(24)11-26-19/h2-9,11,17,24H,10H2,1H3
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n/an/a 7.59E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant cytoplasmic domain of HER2 expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...

Bioorg Med Chem 20: 2010-8 (2012)


Article DOI: 10.1016/j.bmc.2012.01.051
BindingDB Entry DOI: 10.7270/Q27081WW
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50365936
PNG
(CHEMBL1958211)
Show SMILES COc1ccc(cc1)C1CC(=NN1c1nc(O)cs1)c1ccc(Br)cc1 |c:11|
Show InChI InChI=1S/C19H16BrN3O2S/c1-25-15-8-4-13(5-9-15)17-10-16(12-2-6-14(20)7-3-12)22-23(17)19-21-18(24)11-26-19/h2-9,11,17,24H,10H2,1H3
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n/an/a 7.96E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant cytoplasmic domain of EGFR expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...

Bioorg Med Chem 20: 2010-8 (2012)


Article DOI: 10.1016/j.bmc.2012.01.051
BindingDB Entry DOI: 10.7270/Q27081WW
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))		BDBM50365908
PNG
(CHEMBL1958219)
Show SMILES COc1ccc(cc1)C1=NN(C(C1)c1ccc(F)cc1)c1nc(O)cs1 |t:9|
Show InChI InChI=1S/C19H16FN3O2S/c1-25-15-8-4-12(5-9-15)16-10-17(13-2-6-14(20)7-3-13)23(22-16)19-21-18(24)11-26-19/h2-9,11,17,24H,10H2,1H3
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n/an/a 8.04E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant cytoplasmic domain of HER2 expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...

Bioorg Med Chem 20: 2010-8 (2012)


Article DOI: 10.1016/j.bmc.2012.01.051
BindingDB Entry DOI: 10.7270/Q27081WW
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))		BDBM50365929
PNG
(CHEMBL1958035)
Show SMILES Cc1ccc(cc1)C1CC(=NN1c1nc(O)cs1)c1ccc(Cl)cc1 |c:10|
Show InChI InChI=1S/C19H16ClN3OS/c1-12-2-4-14(5-3-12)17-10-16(13-6-8-15(20)9-7-13)22-23(17)19-21-18(24)11-25-19/h2-9,11,17,24H,10H2,1H3
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n/an/a 8.13E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant cytoplasmic domain of HER2 expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...

Bioorg Med Chem 20: 2010-8 (2012)


Article DOI: 10.1016/j.bmc.2012.01.051
BindingDB Entry DOI: 10.7270/Q27081WW
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50365919
PNG
(CHEMBL1958025)
Show SMILES Oc1csc(n1)N1N=C(CC1c1ccccc1)c1ccc(F)cc1 |c:8|
Show InChI InChI=1S/C18H14FN3OS/c19-14-8-6-12(7-9-14)15-10-16(13-4-2-1-3-5-13)22(21-15)18-20-17(23)11-24-18/h1-9,11,16,23H,10H2
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n/an/a 8.14E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant cytoplasmic domain of EGFR expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...

Bioorg Med Chem 20: 2010-8 (2012)


Article DOI: 10.1016/j.bmc.2012.01.051
BindingDB Entry DOI: 10.7270/Q27081WW
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))		BDBM50365932
PNG
(CHEMBL1958038)
Show SMILES Oc1csc(n1)N1N=C(CC1c1ccc(F)cc1)c1ccc(Br)cc1 |c:8|
Show InChI InChI=1S/C18H13BrFN3OS/c19-13-5-1-11(2-6-13)15-9-16(12-3-7-14(20)8-4-12)23(22-15)18-21-17(24)10-25-18/h1-8,10,16,24H,9H2
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n/an/a 8.14E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant cytoplasmic domain of HER2 expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...

Bioorg Med Chem 20: 2010-8 (2012)


Article DOI: 10.1016/j.bmc.2012.01.051
BindingDB Entry DOI: 10.7270/Q27081WW
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50365927
PNG
(CHEMBL1958033)
Show SMILES Oc1csc(n1)N1N=C(CC1c1ccc(Cl)cc1)c1ccc(Cl)cc1 |c:8|
Show InChI InChI=1S/C18H13Cl2N3OS/c19-13-5-1-11(2-6-13)15-9-16(12-3-7-14(20)8-4-12)23(22-15)18-21-17(24)10-25-18/h1-8,10,16,24H,9H2
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n/an/a 8.16E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant cytoplasmic domain of EGFR expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...

Bioorg Med Chem 20: 2010-8 (2012)


Article DOI: 10.1016/j.bmc.2012.01.051
BindingDB Entry DOI: 10.7270/Q27081WW
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50365923
PNG
(CHEMBL1958029)
Show SMILES Cc1ccc(cc1)C1CC(=NN1c1nc(O)cs1)c1ccc(F)cc1 |c:10|
Show InChI InChI=1S/C19H16FN3OS/c1-12-2-4-14(5-3-12)17-10-16(13-6-8-15(20)9-7-13)22-23(17)19-21-18(24)11-25-19/h2-9,11,17,24H,10H2,1H3
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n/an/a 8.36E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant cytoplasmic domain of EGFR expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...

Bioorg Med Chem 20: 2010-8 (2012)


Article DOI: 10.1016/j.bmc.2012.01.051
BindingDB Entry DOI: 10.7270/Q27081WW
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50365930
PNG
(CHEMBL1958036)
Show SMILES COc1ccc(cc1)C1CC(=NN1c1nc(O)cs1)c1ccc(Cl)cc1 |c:11|
Show InChI InChI=1S/C19H16ClN3O2S/c1-25-15-8-4-13(5-9-15)17-10-16(12-2-6-14(20)7-3-12)22-23(17)19-21-18(24)11-26-19/h2-9,11,17,24H,10H2,1H3
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n/an/a 8.58E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant cytoplasmic domain of EGFR expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...

Bioorg Med Chem 20: 2010-8 (2012)


Article DOI: 10.1016/j.bmc.2012.01.051
BindingDB Entry DOI: 10.7270/Q27081WW
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50365912
PNG
(CHEMBL1958223)
Show SMILES COc1ccc(cc1)C1CC(=NN1c1nc(O)cs1)c1ccc(OC)cc1 |c:11|
Show InChI InChI=1S/C20H19N3O3S/c1-25-15-7-3-13(4-8-15)17-11-18(14-5-9-16(26-2)10-6-14)23(22-17)20-21-19(24)12-27-20/h3-10,12,18,24H,11H2,1-2H3
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n/an/a 8.89E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant cytoplasmic domain of EGFR expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...

Bioorg Med Chem 20: 2010-8 (2012)


Article DOI: 10.1016/j.bmc.2012.01.051
BindingDB Entry DOI: 10.7270/Q27081WW
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))		BDBM50365936
PNG
(CHEMBL1958211)
Show SMILES COc1ccc(cc1)C1CC(=NN1c1nc(O)cs1)c1ccc(Br)cc1 |c:11|
Show InChI InChI=1S/C19H16BrN3O2S/c1-25-15-8-4-13(5-9-15)17-10-16(12-2-6-14(20)7-3-12)22-23(17)19-21-18(24)11-26-19/h2-9,11,17,24H,10H2,1H3
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n/an/a 9.27E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant cytoplasmic domain of HER2 expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...

Bioorg Med Chem 20: 2010-8 (2012)


Article DOI: 10.1016/j.bmc.2012.01.051
BindingDB Entry DOI: 10.7270/Q27081WW
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))		BDBM50365927
PNG
(CHEMBL1958033)
Show SMILES Oc1csc(n1)N1N=C(CC1c1ccc(Cl)cc1)c1ccc(Cl)cc1 |c:8|
Show InChI InChI=1S/C18H13Cl2N3OS/c19-13-5-1-11(2-6-13)15-9-16(12-3-7-14(20)8-4-12)23(22-15)18-21-17(24)10-25-18/h1-8,10,16,24H,9H2
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n/an/a 9.96E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant cytoplasmic domain of HER2 expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...

Bioorg Med Chem 20: 2010-8 (2012)


Article DOI: 10.1016/j.bmc.2012.01.051
BindingDB Entry DOI: 10.7270/Q27081WW
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))		BDBM50365923
PNG
(CHEMBL1958029)
Show SMILES Cc1ccc(cc1)C1CC(=NN1c1nc(O)cs1)c1ccc(F)cc1 |c:10|
Show InChI InChI=1S/C19H16FN3OS/c1-12-2-4-14(5-3-12)17-10-16(13-6-8-15(20)9-7-13)22-23(17)19-21-18(24)11-25-19/h2-9,11,17,24H,10H2,1H3
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n/an/a 1.03E+4n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant cytoplasmic domain of HER2 expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...

Bioorg Med Chem 20: 2010-8 (2012)


Article DOI: 10.1016/j.bmc.2012.01.051
BindingDB Entry DOI: 10.7270/Q27081WW
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))		BDBM50365930
PNG
(CHEMBL1958036)
Show SMILES COc1ccc(cc1)C1CC(=NN1c1nc(O)cs1)c1ccc(Cl)cc1 |c:11|
Show InChI InChI=1S/C19H16ClN3O2S/c1-25-15-8-4-13(5-9-15)17-10-16(12-2-6-14(20)7-3-12)22-23(17)19-21-18(24)11-26-19/h2-9,11,17,24H,10H2,1H3
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n/an/a 1.03E+4n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant cytoplasmic domain of HER2 expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...

Bioorg Med Chem 20: 2010-8 (2012)


Article DOI: 10.1016/j.bmc.2012.01.051
BindingDB Entry DOI: 10.7270/Q27081WW
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))		BDBM50365912
PNG
(CHEMBL1958223)
Show SMILES COc1ccc(cc1)C1CC(=NN1c1nc(O)cs1)c1ccc(OC)cc1 |c:11|
Show InChI InChI=1S/C20H19N3O3S/c1-25-15-7-3-13(4-8-15)17-11-18(14-5-9-16(26-2)10-6-14)23(22-17)20-21-19(24)12-27-20/h3-10,12,18,24H,11H2,1-2H3
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n/an/a 1.05E+4n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant cytoplasmic domain of HER2 expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...

Bioorg Med Chem 20: 2010-8 (2012)


Article DOI: 10.1016/j.bmc.2012.01.051
BindingDB Entry DOI: 10.7270/Q27081WW
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))		BDBM50365919
PNG
(CHEMBL1958025)
Show SMILES Oc1csc(n1)N1N=C(CC1c1ccccc1)c1ccc(F)cc1 |c:8|
Show InChI InChI=1S/C18H14FN3OS/c19-14-8-6-12(7-9-14)15-10-16(13-4-2-1-3-5-13)22(21-15)18-20-17(23)11-24-18/h1-9,11,16,23H,10H2
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n/an/a 1.05E+4n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant cytoplasmic domain of HER2 expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...

Bioorg Med Chem 20: 2010-8 (2012)


Article DOI: 10.1016/j.bmc.2012.01.051
BindingDB Entry DOI: 10.7270/Q27081WW
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50365924
PNG
(CHEMBL1958030)
Show SMILES COc1ccc(cc1)C1CC(=NN1c1nc(O)cs1)c1ccc(F)cc1 |c:11|
Show InChI InChI=1S/C19H16FN3O2S/c1-25-15-8-4-13(5-9-15)17-10-16(12-2-6-14(20)7-3-12)22-23(17)19-21-18(24)11-26-19/h2-9,11,17,24H,10H2,1H3
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n/an/a 1.07E+4n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant cytoplasmic domain of EGFR expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...

Bioorg Med Chem 20: 2010-8 (2012)


Article DOI: 10.1016/j.bmc.2012.01.051
BindingDB Entry DOI: 10.7270/Q27081WW
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50365921
PNG
(CHEMBL1958027)
Show SMILES Oc1csc(n1)N1N=C(CC1c1ccc(Cl)cc1)c1ccc(F)cc1 |c:8|
Show InChI InChI=1S/C18H13ClFN3OS/c19-13-5-1-12(2-6-13)16-9-15(11-3-7-14(20)8-4-11)22-23(16)18-21-17(24)10-25-18/h1-8,10,16,24H,9H2
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n/an/a 1.09E+4n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant cytoplasmic domain of EGFR expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...

Bioorg Med Chem 20: 2010-8 (2012)


Article DOI: 10.1016/j.bmc.2012.01.051
BindingDB Entry DOI: 10.7270/Q27081WW
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))		BDBM50365924
PNG
(CHEMBL1958030)
Show SMILES COc1ccc(cc1)C1CC(=NN1c1nc(O)cs1)c1ccc(F)cc1 |c:11|
Show InChI InChI=1S/C19H16FN3O2S/c1-25-15-8-4-13(5-9-15)17-10-16(12-2-6-14(20)7-3-12)22-23(17)19-21-18(24)11-26-19/h2-9,11,17,24H,10H2,1H3
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n/an/a 1.24E+4n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant cytoplasmic domain of HER2 expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...

Bioorg Med Chem 20: 2010-8 (2012)


Article DOI: 10.1016/j.bmc.2012.01.051
BindingDB Entry DOI: 10.7270/Q27081WW
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))		BDBM50365921
PNG
(CHEMBL1958027)
Show SMILES Oc1csc(n1)N1N=C(CC1c1ccc(Cl)cc1)c1ccc(F)cc1 |c:8|
Show InChI InChI=1S/C18H13ClFN3OS/c19-13-5-1-12(2-6-13)16-9-15(11-3-7-14(20)8-4-11)22-23(16)18-21-17(24)10-25-18/h1-8,10,16,24H,9H2
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n/an/a 1.32E+4n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant cytoplasmic domain of HER2 expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...

Bioorg Med Chem 20: 2010-8 (2012)


Article DOI: 10.1016/j.bmc.2012.01.051
BindingDB Entry DOI: 10.7270/Q27081WW
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50365926
PNG
(CHEMBL1958032)
Show SMILES Oc1csc(n1)N1N=C(CC1c1ccc(F)cc1)c1ccc(Cl)cc1 |c:8|
Show InChI InChI=1S/C18H13ClFN3OS/c19-13-5-1-11(2-6-13)15-9-16(12-3-7-14(20)8-4-12)23(22-15)18-21-17(24)10-25-18/h1-8,10,16,24H,9H2
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n/an/a 1.42E+4n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant cytoplasmic domain of EGFR expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...

Bioorg Med Chem 20: 2010-8 (2012)


Article DOI: 10.1016/j.bmc.2012.01.051
BindingDB Entry DOI: 10.7270/Q27081WW
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))		BDBM50365926
PNG
(CHEMBL1958032)
Show SMILES Oc1csc(n1)N1N=C(CC1c1ccc(F)cc1)c1ccc(Cl)cc1 |c:8|
Show InChI InChI=1S/C18H13ClFN3OS/c19-13-5-1-11(2-6-13)15-9-16(12-3-7-14(20)8-4-12)23(22-15)18-21-17(24)10-25-18/h1-8,10,16,24H,9H2
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n/an/a 1.64E+4n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant cytoplasmic domain of HER2 expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...

Bioorg Med Chem 20: 2010-8 (2012)


Article DOI: 10.1016/j.bmc.2012.01.051
BindingDB Entry DOI: 10.7270/Q27081WW
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50365920
PNG
(CHEMBL1958026)
Show SMILES Oc1csc(n1)N1N=C(CC1c1ccc(F)cc1)c1ccc(F)cc1 |c:8|
Show InChI InChI=1S/C18H13F2N3OS/c19-13-5-1-11(2-6-13)15-9-16(12-3-7-14(20)8-4-12)23(22-15)18-21-17(24)10-25-18/h1-8,10,16,24H,9H2
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n/an/a 1.69E+4n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant cytoplasmic domain of EGFR expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...

Bioorg Med Chem 20: 2010-8 (2012)


Article DOI: 10.1016/j.bmc.2012.01.051
BindingDB Entry DOI: 10.7270/Q27081WW
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))		BDBM50365920
PNG
(CHEMBL1958026)
Show SMILES Oc1csc(n1)N1N=C(CC1c1ccc(F)cc1)c1ccc(F)cc1 |c:8|
Show InChI InChI=1S/C18H13F2N3OS/c19-13-5-1-11(2-6-13)15-9-16(12-3-7-14(20)8-4-12)23(22-15)18-21-17(24)10-25-18/h1-8,10,16,24H,9H2
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n/an/a 1.81E+4n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant cytoplasmic domain of HER2 expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/t...

Bioorg Med Chem 20: 2010-8 (2012)


Article DOI: 10.1016/j.bmc.2012.01.051
BindingDB Entry DOI: 10.7270/Q27081WW
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%