Affinity Data by PubMed id=22369181

PubMed code 22369181

Found 6 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Peroxisome proliferator-activated receptor delta (Mus musculus)	BDBM50383371 (CHEMBL2030550) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	9.5	n/a	n/a	n/a	n/a	n/a	n/a
Philipps University Curated by ChEMBL					Assay Description Inverse agonist activity at PPARbeta/delta in mouse C2C12 cells assessed as inhibition of Angptl4 expression after 24 hrs by RT-qPCR analysis				J Med Chem 55: 2858-68 (2012) Article DOI: 10.1021/jm2017122 BindingDB Entry DOI: 10.7270/Q2XK8GK9
Philipps University Curated by ChEMBL					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (Mus musculus)	BDBM50383371 (CHEMBL2030550) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	26.9	n/a	n/a	n/a	n/a	n/a	n/a
Philipps University Curated by ChEMBL					Assay Description Displacement of fluormone Pan-PPAR Green from mouse recombinant GST-tagged PPARbeta/delta LBD after 60 mins by TR-FRET assay				J Med Chem 55: 2858-68 (2012) Article DOI: 10.1021/jm2017122 BindingDB Entry DOI: 10.7270/Q2XK8GK9
Philipps University Curated by ChEMBL					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (Mus musculus)	BDBM50383373 (CHEMBL592652 \| GSK0660) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	48	n/a	n/a	n/a	n/a	n/a	n/a
Philipps University Curated by ChEMBL					Assay Description Inverse agonist activity at PPARbeta/delta in mouse C2C12 cells assessed as inhibition of Angptl4 expression after 24 hrs by RT-qPCR analysis				J Med Chem 55: 2858-68 (2012) Article DOI: 10.1021/jm2017122 BindingDB Entry DOI: 10.7270/Q2XK8GK9
Philipps University Curated by ChEMBL					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (Mus musculus)	BDBM50383370 (CHEMBL2030543) Show SMILES CN(C)c1ccc(\C=C(/C#N)c2ccccc2Cl)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	52	n/a	n/a	n/a	n/a	n/a	n/a
Philipps University Curated by ChEMBL					Assay Description Inverse agonist activity at PPARbeta/delta in mouse C2C12 cells assessed as inhibition of Angptl4 expression after 24 hrs by RT-qPCR analysis				J Med Chem 55: 2858-68 (2012) Article DOI: 10.1021/jm2017122 BindingDB Entry DOI: 10.7270/Q2XK8GK9
Philipps University Curated by ChEMBL					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (Mus musculus)	BDBM50383370 (CHEMBL2030543) Show SMILES CN(C)c1ccc(\C=C(/C#N)c2ccccc2Cl)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
Philipps University Curated by ChEMBL					Assay Description Displacement of fluormone Pan-PPAR Green from mouse recombinant GST-tagged PPARbeta/delta LBD after 60 mins by TR-FRET assay				J Med Chem 55: 2858-68 (2012) Article DOI: 10.1021/jm2017122 BindingDB Entry DOI: 10.7270/Q2XK8GK9
Philipps University Curated by ChEMBL					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor delta (Mus musculus)	BDBM50383372 (CHEMBL1998001) Show SMILES CN(C)c1ccc(\C=C(/C#N)c2ccccc2)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>500	n/a	n/a	n/a	n/a	n/a	n/a
Philipps University Curated by ChEMBL					Assay Description Inverse agonist activity at PPARbeta/delta in mouse C2C12 cells assessed as inhibition of Angptl4 expression after 24 hrs by RT-qPCR analysis				J Med Chem 55: 2858-68 (2012) Article DOI: 10.1021/jm2017122 BindingDB Entry DOI: 10.7270/Q2XK8GK9
Philipps University Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%