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PubMed code 22386260

Compile data set for download or QSAR
Found 9 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50365178
PNG
(CHEMBL1950228)
Show SMILES O=Cc1cn2CCCCn3c4ccccc4c4ccc1c2c34
Show InChI InChI=1S/C19H16N2O/c22-12-13-11-20-9-3-4-10-21-17-6-2-1-5-15(17)16-8-7-14(13)18(20)19(16)21/h1-2,5-8,11-12H,3-4,9-10H2
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n/an/a 8n/an/an/an/an/an/a



Clermont Universit£

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His6-tagged PIM1 expressed in Sf21 cells using RSRHSSYPAGT as substrate after 30 mins

Eur J Med Chem 50: 304-10 (2012)


Article DOI: 10.1016/j.ejmech.2012.02.009
BindingDB Entry DOI: 10.7270/Q22N52QX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))		BDBM50365178
PNG
(CHEMBL1950228)
Show SMILES O=Cc1cn2CCCCn3c4ccccc4c4ccc1c2c34
Show InChI InChI=1S/C19H16N2O/c22-12-13-11-20-9-3-4-10-21-17-6-2-1-5-15(17)16-8-7-14(13)18(20)19(16)21/h1-2,5-8,11-12H,3-4,9-10H2
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n/an/a 13n/an/an/an/an/an/a



Clermont Universit£

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His6-tagged PIM3 expressed in Sf21 cells using RSRHSSYPAGT as substrate after 30 mins

Eur J Med Chem 50: 304-10 (2012)


Article DOI: 10.1016/j.ejmech.2012.02.009
BindingDB Entry DOI: 10.7270/Q22N52QX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50365179
PNG
(CHEMBL1950229)
Show SMILES [N-]=[N+]=NCCCCn1c2ccccc2c2ccc3c(C=O)c[nH]c3c12
Show InChI InChI=1S/C19H17N5O/c20-23-22-9-3-4-10-24-17-6-2-1-5-15(17)16-8-7-14-13(12-25)11-21-18(14)19(16)24/h1-2,5-8,11-12,21H,3-4,9-10H2
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n/an/a 105n/an/an/an/an/an/a



Clermont Universit£

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His6-tagged PIM1 expressed in Sf21 cells using RSRHSSYPAGT as substrate after 30 mins

Eur J Med Chem 50: 304-10 (2012)


Article DOI: 10.1016/j.ejmech.2012.02.009
BindingDB Entry DOI: 10.7270/Q22N52QX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))		BDBM50365179
PNG
(CHEMBL1950229)
Show SMILES [N-]=[N+]=NCCCCn1c2ccccc2c2ccc3c(C=O)c[nH]c3c12
Show InChI InChI=1S/C19H17N5O/c20-23-22-9-3-4-10-24-17-6-2-1-5-15(17)16-8-7-14-13(12-25)11-21-18(14)19(16)24/h1-2,5-8,11-12,21H,3-4,9-10H2
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n/an/a 108n/an/an/an/an/an/a



Clermont Universit£

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His6-tagged PIM3 expressed in Sf21 cells using RSRHSSYPAGT as substrate after 30 mins

Eur J Med Chem 50: 304-10 (2012)


Article DOI: 10.1016/j.ejmech.2012.02.009
BindingDB Entry DOI: 10.7270/Q22N52QX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))		BDBM50365180
PNG
(CHEMBL1950230)
Show SMILES OCc1cn(CCCCn2c3ccccc3c3ccc4c(C=O)c[nH]c4c23)nn1
Show InChI InChI=1S/C22H21N5O2/c28-13-15-11-23-21-17(15)7-8-19-18-5-1-2-6-20(18)27(22(19)21)10-4-3-9-26-12-16(14-29)24-25-26/h1-2,5-8,11-13,23,29H,3-4,9-10,14H2
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n/an/a 235n/an/an/an/an/an/a



Clermont Universit£

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His6-tagged PIM3 expressed in Sf21 cells using RSRHSSYPAGT as substrate after 30 mins

Eur J Med Chem 50: 304-10 (2012)


Article DOI: 10.1016/j.ejmech.2012.02.009
BindingDB Entry DOI: 10.7270/Q22N52QX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50365180
PNG
(CHEMBL1950230)
Show SMILES OCc1cn(CCCCn2c3ccccc3c3ccc4c(C=O)c[nH]c4c23)nn1
Show InChI InChI=1S/C22H21N5O2/c28-13-15-11-23-21-17(15)7-8-19-18-5-1-2-6-20(18)27(22(19)21)10-4-3-9-26-12-16(14-29)24-25-26/h1-2,5-8,11-13,23,29H,3-4,9-10,14H2
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n/an/a 315n/an/an/an/an/an/a



Clermont Universit£

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His6-tagged PIM1 expressed in Sf21 cells using RSRHSSYPAGT as substrate after 30 mins

Eur J Med Chem 50: 304-10 (2012)


Article DOI: 10.1016/j.ejmech.2012.02.009
BindingDB Entry DOI: 10.7270/Q22N52QX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50365181
PNG
(CHEMBL1950358)
Show SMILES C[N+](C)(CCO)Cc1cn(CCCCn2c3ccccc3c3ccc4c(C=O)c[nH]c4c23)nn1
Show InChI InChI=1S/C26H30N6O2/c1-32(2,13-14-33)17-20-16-30(29-28-20)11-5-6-12-31-24-8-4-3-7-22(24)23-10-9-21-19(18-34)15-27-25(21)26(23)31/h3-4,7-10,15-16,18,33H,5-6,11-14,17H2,1-2H3/p+1
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n/an/a 327n/an/an/an/an/an/a



Clermont Universit£

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His6-tagged PIM1 expressed in Sf21 cells using RSRHSSYPAGT as substrate after 30 mins

Eur J Med Chem 50: 304-10 (2012)


Article DOI: 10.1016/j.ejmech.2012.02.009
BindingDB Entry DOI: 10.7270/Q22N52QX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM50365178
PNG
(CHEMBL1950228)
Show SMILES O=Cc1cn2CCCCn3c4ccccc4c4ccc1c2c34
Show InChI InChI=1S/C19H16N2O/c22-12-13-11-20-9-3-4-10-21-17-6-2-1-5-15(17)16-8-7-14(13)18(20)19(16)21/h1-2,5-8,11-12H,3-4,9-10H2
PDB
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KEGG

UniProtKB/SwissProt

B.MOAD
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GoogleScholar
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CHEMBL
PC cid
PC sid
UniChem
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PubMed
n/an/a 350n/an/an/an/an/an/a



Clermont Universit£

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PIM2 expressed in Escherichia coli using RSRHSSYPAGT as substrate after 30 mins

Eur J Med Chem 50: 304-10 (2012)


Article DOI: 10.1016/j.ejmech.2012.02.009
BindingDB Entry DOI: 10.7270/Q22N52QX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))		BDBM50365181
PNG
(CHEMBL1950358)
Show SMILES C[N+](C)(CCO)Cc1cn(CCCCn2c3ccccc3c3ccc4c(C=O)c[nH]c4c23)nn1
Show InChI InChI=1S/C26H30N6O2/c1-32(2,13-14-33)17-20-16-30(29-28-20)11-5-6-12-31-24-8-4-3-7-22(24)23-10-9-21-19(18-34)15-27-25(21)26(23)31/h3-4,7-10,15-16,18,33H,5-6,11-14,17H2,1-2H3/p+1
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 490n/an/an/an/an/an/a



Clermont Universit£

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His6-tagged PIM3 expressed in Sf21 cells using RSRHSSYPAGT as substrate after 30 mins

Eur J Med Chem 50: 304-10 (2012)


Article DOI: 10.1016/j.ejmech.2012.02.009
BindingDB Entry DOI: 10.7270/Q22N52QX
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%