BindingDB logo
myBDB logout

PubMed code 22429471

Compile data set for download or QSAR
Found 64 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Calcitonin gene-related peptide type 1 receptor


(Homo sapiens (Human))		BDBM50380812
PNG
(CHEMBL2018517)
Show SMILES Cc1cc(C[C@@H](CC(=O)N2CCC(CC2)N2Cc3ccccc3NC2=O)C(=O)N2CCC(CC2)N2CCCCC2)cc2cn[nH]c12 |r|
Show InChI InChI=1S/C36H47N7O3/c1-25-19-26(21-29-23-37-39-34(25)29)20-28(35(45)42-17-9-30(10-18-42)40-13-5-2-6-14-40)22-33(44)41-15-11-31(12-16-41)43-24-27-7-3-4-8-32(27)38-36(43)46/h3-4,7-8,19,21,23,28,30-31H,2,5-6,9-18,20,22,24H2,1H3,(H,37,39)(H,38,46)/t28-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 0.0190n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Antagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production

Bioorg Med Chem Lett 22: 2912-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.066
BindingDB Entry DOI: 10.7270/Q2SN0B0F
More data for this
Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor


(Homo sapiens (Human))		BDBM50380831
PNG
(CHEMBL2018507)
Show SMILES Cc1cc(CC(CC(=O)N2CCC(CC2)n2cc([nH]c2=O)-c2ccccc2)C(=O)N2CCC(CC2)N2CCCCC2)cc2cn[nH]c12
Show InChI InChI=1S/C37H47N7O3/c1-26-20-27(22-30-24-38-40-35(26)30)21-29(36(46)43-18-10-31(11-19-43)41-14-6-3-7-15-41)23-34(45)42-16-12-32(13-17-42)44-25-33(39-37(44)47)28-8-4-2-5-9-28/h2,4-5,8-9,20,22,24-25,29,31-32H,3,6-7,10-19,21,23H2,1H3,(H,38,40)(H,39,47)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 0.0490n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Antagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production

Bioorg Med Chem Lett 22: 2912-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.066
BindingDB Entry DOI: 10.7270/Q2SN0B0F
More data for this
Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor


(Homo sapiens (Human))		BDBM50380812
PNG
(CHEMBL2018517)
Show SMILES Cc1cc(C[C@@H](CC(=O)N2CCC(CC2)N2Cc3ccccc3NC2=O)C(=O)N2CCC(CC2)N2CCCCC2)cc2cn[nH]c12 |r|
Show InChI InChI=1S/C36H47N7O3/c1-25-19-26(21-29-23-37-39-34(25)29)20-28(35(45)42-17-9-30(10-18-42)40-13-5-2-6-14-40)22-33(44)41-15-11-31(12-16-41)43-24-27-7-3-4-8-32(27)38-36(43)46/h3-4,7-8,19,21,23,28,30-31H,2,5-6,9-18,20,22,24H2,1H3,(H,37,39)(H,38,46)/t28-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 0.0600n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting

Bioorg Med Chem Lett 22: 2912-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.066
BindingDB Entry DOI: 10.7270/Q2SN0B0F
More data for this
Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor


(Homo sapiens (Human))		BDBM50380812
PNG
(CHEMBL2018517)
Show SMILES Cc1cc(C[C@@H](CC(=O)N2CCC(CC2)N2Cc3ccccc3NC2=O)C(=O)N2CCC(CC2)N2CCCCC2)cc2cn[nH]c12 |r|
Show InChI InChI=1S/C36H47N7O3/c1-25-19-26(21-29-23-37-39-34(25)29)20-28(35(45)42-17-9-30(10-18-42)40-13-5-2-6-14-40)22-33(44)41-15-11-31(12-16-41)43-24-27-7-3-4-8-32(27)38-36(43)46/h3-4,7-8,19,21,23,28,30-31H,2,5-6,9-18,20,22,24H2,1H3,(H,37,39)(H,38,46)/t28-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 0.0680n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Antagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production

Bioorg Med Chem Lett 22: 2912-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.066
BindingDB Entry DOI: 10.7270/Q2SN0B0F
More data for this
Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor


(Homo sapiens (Human))		BDBM50380812
PNG
(CHEMBL2018517)
Show SMILES Cc1cc(C[C@@H](CC(=O)N2CCC(CC2)N2Cc3ccccc3NC2=O)C(=O)N2CCC(CC2)N2CCCCC2)cc2cn[nH]c12 |r|
Show InChI InChI=1S/C36H47N7O3/c1-25-19-26(21-29-23-37-39-34(25)29)20-28(35(45)42-17-9-30(10-18-42)40-13-5-2-6-14-40)22-33(44)41-15-11-31(12-16-41)43-24-27-7-3-4-8-32(27)38-36(43)46/h3-4,7-8,19,21,23,28,30-31H,2,5-6,9-18,20,22,24H2,1H3,(H,37,39)(H,38,46)/t28-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 0.0740n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting

Bioorg Med Chem Lett 22: 2912-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.066
BindingDB Entry DOI: 10.7270/Q2SN0B0F
More data for this
Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor


(Homo sapiens (Human))		BDBM50380820
PNG
(CHEMBL2018519)
Show SMILES Cc1cc(C[C@@H](CC(=O)N2CCC(CC2)N2Cc3cccc(F)c3NC2=O)C(=O)N2CCC(CC2)N2CCCCC2)cc2cn[nH]c12 |r|
Show InChI InChI=1S/C36H46FN7O3/c1-24-18-25(20-28-22-38-40-33(24)28)19-27(35(46)43-16-8-29(9-17-43)41-12-3-2-4-13-41)21-32(45)42-14-10-30(11-15-42)44-23-26-6-5-7-31(37)34(26)39-36(44)47/h5-7,18,20,22,27,29-30H,2-4,8-17,19,21,23H2,1H3,(H,38,40)(H,39,47)/t27-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 0.0820n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Antagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production

Bioorg Med Chem Lett 22: 2912-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.066
BindingDB Entry DOI: 10.7270/Q2SN0B0F
More data for this
Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor


(Homo sapiens (Human))		BDBM50380814
PNG
(CHEMBL2018505)
Show SMILES Cc1cc(CC(CC(=O)N2CCC(CC2)N2Cc3cccc(F)c3NC2=O)C(=O)N2CCC(CC2)N2CCCCC2)cc2cn[nH]c12
Show InChI InChI=1S/C36H46FN7O3/c1-24-18-25(20-28-22-38-40-33(24)28)19-27(35(46)43-16-8-29(9-17-43)41-12-3-2-4-13-41)21-32(45)42-14-10-30(11-15-42)44-23-26-6-5-7-31(37)34(26)39-36(44)47/h5-7,18,20,22,27,29-30H,2-4,8-17,19,21,23H2,1H3,(H,38,40)(H,39,47)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 0.0890n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Antagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production

Bioorg Med Chem Lett 22: 2912-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.066
BindingDB Entry DOI: 10.7270/Q2SN0B0F
More data for this
Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor


(Homo sapiens (Human))		BDBM50380832
PNG
(CHEMBL2018508)
Show SMILES Cc1cc(CC(CC(=O)N2CCC(CC2)c2cc3ccccc3[nH]c2=O)C(=O)N2CCC(CC2)N2CCCCC2)cc2cn[nH]c12
Show InChI InChI=1S/C37H46N6O3/c1-25-19-26(21-30-24-38-40-35(25)30)20-29(37(46)43-17-11-31(12-18-43)41-13-5-2-6-14-41)23-34(44)42-15-9-27(10-16-42)32-22-28-7-3-4-8-33(28)39-36(32)45/h3-4,7-8,19,21-22,24,27,29,31H,2,5-6,9-18,20,23H2,1H3,(H,38,40)(H,39,45)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 0.120n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Antagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production

Bioorg Med Chem Lett 22: 2912-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.066
BindingDB Entry DOI: 10.7270/Q2SN0B0F
More data for this
Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor


(Homo sapiens (Human))		BDBM50380831
PNG
(CHEMBL2018507)
Show SMILES Cc1cc(CC(CC(=O)N2CCC(CC2)n2cc([nH]c2=O)-c2ccccc2)C(=O)N2CCC(CC2)N2CCCCC2)cc2cn[nH]c12
Show InChI InChI=1S/C37H47N7O3/c1-26-20-27(22-30-24-38-40-35(26)30)21-29(36(46)43-18-10-31(11-19-43)41-14-6-3-7-15-41)23-34(45)42-16-12-32(13-17-42)44-25-33(39-37(44)47)28-8-4-2-5-9-28/h2,4-5,8-9,20,22,24-25,29,31-32H,3,6-7,10-19,21,23H2,1H3,(H,38,40)(H,39,47)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 0.150n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting

Bioorg Med Chem Lett 22: 2912-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.066
BindingDB Entry DOI: 10.7270/Q2SN0B0F
More data for this
Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor


(Homo sapiens (Human))		BDBM50380814
PNG
(CHEMBL2018505)
Show SMILES Cc1cc(CC(CC(=O)N2CCC(CC2)N2Cc3cccc(F)c3NC2=O)C(=O)N2CCC(CC2)N2CCCCC2)cc2cn[nH]c12
Show InChI InChI=1S/C36H46FN7O3/c1-24-18-25(20-28-22-38-40-33(24)28)19-27(35(46)43-16-8-29(9-17-43)41-12-3-2-4-13-41)21-32(45)42-14-10-30(11-15-42)44-23-26-6-5-7-31(37)34(26)39-36(44)47/h5-7,18,20,22,27,29-30H,2-4,8-17,19,21,23H2,1H3,(H,38,40)(H,39,47)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 0.180n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting

Bioorg Med Chem Lett 22: 2912-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.066
BindingDB Entry DOI: 10.7270/Q2SN0B0F
More data for this
Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor


(Homo sapiens (Human))		BDBM50380820
PNG
(CHEMBL2018519)
Show SMILES Cc1cc(C[C@@H](CC(=O)N2CCC(CC2)N2Cc3cccc(F)c3NC2=O)C(=O)N2CCC(CC2)N2CCCCC2)cc2cn[nH]c12 |r|
Show InChI InChI=1S/C36H46FN7O3/c1-24-18-25(20-28-22-38-40-33(24)28)19-27(35(46)43-16-8-29(9-17-43)41-12-3-2-4-13-41)21-32(45)42-14-10-30(11-15-42)44-23-26-6-5-7-31(37)34(26)39-36(44)47/h5-7,18,20,22,27,29-30H,2-4,8-17,19,21,23H2,1H3,(H,38,40)(H,39,47)/t27-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 0.200n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting

Bioorg Med Chem Lett 22: 2912-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.066
BindingDB Entry DOI: 10.7270/Q2SN0B0F
More data for this
Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor


(Homo sapiens (Human))		BDBM50380832
PNG
(CHEMBL2018508)
Show SMILES Cc1cc(CC(CC(=O)N2CCC(CC2)c2cc3ccccc3[nH]c2=O)C(=O)N2CCC(CC2)N2CCCCC2)cc2cn[nH]c12
Show InChI InChI=1S/C37H46N6O3/c1-25-19-26(21-30-24-38-40-35(25)30)20-29(37(46)43-17-11-31(12-18-43)41-13-5-2-6-14-41)23-34(44)42-15-9-27(10-16-42)32-22-28-7-3-4-8-33(28)39-36(32)45/h3-4,7-8,19,21-22,24,27,29,31H,2,5-6,9-18,20,23H2,1H3,(H,38,40)(H,39,45)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 0.300n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting

Bioorg Med Chem Lett 22: 2912-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.066
BindingDB Entry DOI: 10.7270/Q2SN0B0F
More data for this
Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor


(Homo sapiens (Human))		BDBM50380829
PNG
(CHEMBL2018503)
Show SMILES Cc1cc(CC(CC(=O)N2CCC3(CC2)OC(=O)Nc2ccccc32)C(=O)N2CCC(CC2)N2CCCCC2)cc2cn[nH]c12
Show InChI InChI=1S/C35H44N6O4/c1-24-19-25(21-27-23-36-38-32(24)27)20-26(33(43)41-15-9-28(10-16-41)39-13-5-2-6-14-39)22-31(42)40-17-11-35(12-18-40)29-7-3-4-8-30(29)37-34(44)45-35/h3-4,7-8,19,21,23,26,28H,2,5-6,9-18,20,22H2,1H3,(H,36,38)(H,37,44)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 0.330n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting

Bioorg Med Chem Lett 22: 2912-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.066
BindingDB Entry DOI: 10.7270/Q2SN0B0F
More data for this
Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor


(Homo sapiens (Human))		BDBM50380830
PNG
(CHEMBL2018506)
Show SMILES Cc1cc(CC(CC(=O)N2CCC3(CC2)NC(=O)Nc2ccccc32)C(=O)N2CCC(CC2)N2CCCCC2)cc2cn[nH]c12
Show InChI InChI=1S/C35H45N7O3/c1-24-19-25(21-27-23-36-39-32(24)27)20-26(33(44)42-15-9-28(10-16-42)40-13-5-2-6-14-40)22-31(43)41-17-11-35(12-18-41)29-7-3-4-8-30(29)37-34(45)38-35/h3-4,7-8,19,21,23,26,28H,2,5-6,9-18,20,22H2,1H3,(H,36,39)(H2,37,38,45)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 0.340n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting

Bioorg Med Chem Lett 22: 2912-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.066
BindingDB Entry DOI: 10.7270/Q2SN0B0F
More data for this
Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor


(Homo sapiens (Human))		BDBM50380830
PNG
(CHEMBL2018506)
Show SMILES Cc1cc(CC(CC(=O)N2CCC3(CC2)NC(=O)Nc2ccccc32)C(=O)N2CCC(CC2)N2CCCCC2)cc2cn[nH]c12
Show InChI InChI=1S/C35H45N7O3/c1-24-19-25(21-27-23-36-39-32(24)27)20-26(33(44)42-15-9-28(10-16-42)40-13-5-2-6-14-40)22-31(43)41-17-11-35(12-18-41)29-7-3-4-8-30(29)37-34(45)38-35/h3-4,7-8,19,21,23,26,28H,2,5-6,9-18,20,22H2,1H3,(H,36,39)(H2,37,38,45)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 0.350n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Antagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production

Bioorg Med Chem Lett 22: 2912-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.066
BindingDB Entry DOI: 10.7270/Q2SN0B0F
More data for this
Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor


(Homo sapiens (Human))		BDBM50380829
PNG
(CHEMBL2018503)
Show SMILES Cc1cc(CC(CC(=O)N2CCC3(CC2)OC(=O)Nc2ccccc32)C(=O)N2CCC(CC2)N2CCCCC2)cc2cn[nH]c12
Show InChI InChI=1S/C35H44N6O4/c1-24-19-25(21-27-23-36-38-32(24)27)20-26(33(43)41-15-9-28(10-16-41)39-13-5-2-6-14-39)22-31(42)40-17-11-35(12-18-40)29-7-3-4-8-30(29)37-34(44)45-35/h3-4,7-8,19,21,23,26,28H,2,5-6,9-18,20,22H2,1H3,(H,36,38)(H,37,44)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 0.700n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Antagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production

Bioorg Med Chem Lett 22: 2912-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.066
BindingDB Entry DOI: 10.7270/Q2SN0B0F
More data for this
Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor


(Homo sapiens (Human))		BDBM50380834
PNG
(CHEMBL2018511)
Show SMILES CC1CCN(CC1)C(=O)C(CC(=O)N1CCC(CC1)N1Cc2ccccc2NC1=O)Cc1cc(C)c2[nH]ncc2c1
Show InChI InChI=1S/C32H40N6O3/c1-21-7-11-37(12-8-21)31(40)25(16-23-15-22(2)30-26(17-23)19-33-35-30)18-29(39)36-13-9-27(10-14-36)38-20-24-5-3-4-6-28(24)34-32(38)41/h3-6,15,17,19,21,25,27H,7-14,16,18,20H2,1-2H3,(H,33,35)(H,34,41)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 2n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Antagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production

Bioorg Med Chem Lett 22: 2912-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.066
BindingDB Entry DOI: 10.7270/Q2SN0B0F
More data for this
Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor


(Homo sapiens (Human))		BDBM50380834
PNG
(CHEMBL2018511)
Show SMILES CC1CCN(CC1)C(=O)C(CC(=O)N1CCC(CC1)N1Cc2ccccc2NC1=O)Cc1cc(C)c2[nH]ncc2c1
Show InChI InChI=1S/C32H40N6O3/c1-21-7-11-37(12-8-21)31(40)25(16-23-15-22(2)30-26(17-23)19-33-35-30)18-29(39)36-13-9-27(10-14-36)38-20-24-5-3-4-6-28(24)34-32(38)41/h3-6,15,17,19,21,25,27H,7-14,16,18,20H2,1-2H3,(H,33,35)(H,34,41)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 2.70n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting

Bioorg Med Chem Lett 22: 2912-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.066
BindingDB Entry DOI: 10.7270/Q2SN0B0F
More data for this
Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor


(Homo sapiens (Human))		BDBM50380833
PNG
(CHEMBL2018509)
Show SMILES Cc1cc(CC(CC(=O)N2CCC(CC2)N2Cc3ccccc3NC2=O)C(=O)N2CCC3(CC2)OCCO3)cc2cn[nH]c12
Show InChI InChI=1S/C33H40N6O5/c1-22-16-23(18-26-20-34-36-30(22)26)17-25(31(41)38-12-8-33(9-13-38)43-14-15-44-33)19-29(40)37-10-6-27(7-11-37)39-21-24-4-2-3-5-28(24)35-32(39)42/h2-5,16,18,20,25,27H,6-15,17,19,21H2,1H3,(H,34,36)(H,35,42)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 3.20n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting

Bioorg Med Chem Lett 22: 2912-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.066
BindingDB Entry DOI: 10.7270/Q2SN0B0F
More data for this
Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor


(Homo sapiens (Human))		BDBM50380815
PNG
(CHEMBL2018513)
Show SMILES Cc1cc(CC(CC(=O)N2CCC(CC2)N2Cc3ccccc3NC2=O)C(=O)N2CCCCC2)cc2cn[nH]c12
Show InChI InChI=1S/C31H38N6O3/c1-21-15-22(17-25-19-32-34-29(21)25)16-24(30(39)36-11-5-2-6-12-36)18-28(38)35-13-9-26(10-14-35)37-20-23-7-3-4-8-27(23)33-31(37)40/h3-4,7-8,15,17,19,24,26H,2,5-6,9-14,16,18,20H2,1H3,(H,32,34)(H,33,40)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 3.70n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting

Bioorg Med Chem Lett 22: 2912-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.066
BindingDB Entry DOI: 10.7270/Q2SN0B0F
More data for this
Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor


(Homo sapiens (Human))		BDBM50380821
PNG
(CHEMBL2018520)
Show SMILES Cc1cc(C[C@H](CC(=O)N2CCC(CC2)N2Cc3cccc(F)c3NC2=O)C(=O)N2CCC(CC2)N2CCCCC2)cc2cn[nH]c12 |r|
Show InChI InChI=1S/C36H46FN7O3/c1-24-18-25(20-28-22-38-40-33(24)28)19-27(35(46)43-16-8-29(9-17-43)41-12-3-2-4-13-41)21-32(45)42-14-10-30(11-15-42)44-23-26-6-5-7-31(37)34(26)39-36(44)47/h5-7,18,20,22,27,29-30H,2-4,8-17,19,21,23H2,1H3,(H,38,40)(H,39,47)/t27-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 4.60n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Antagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production

Bioorg Med Chem Lett 22: 2912-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.066
BindingDB Entry DOI: 10.7270/Q2SN0B0F
More data for this
Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor


(Homo sapiens (Human))		BDBM50380833
PNG
(CHEMBL2018509)
Show SMILES Cc1cc(CC(CC(=O)N2CCC(CC2)N2Cc3ccccc3NC2=O)C(=O)N2CCC3(CC2)OCCO3)cc2cn[nH]c12
Show InChI InChI=1S/C33H40N6O5/c1-22-16-23(18-26-20-34-36-30(22)26)17-25(31(41)38-12-8-33(9-13-38)43-14-15-44-33)19-29(40)37-10-6-27(7-11-37)39-21-24-4-2-3-5-28(24)35-32(39)42/h2-5,16,18,20,25,27H,6-15,17,19,21H2,1H3,(H,34,36)(H,35,42)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 5.80n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Antagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production

Bioorg Med Chem Lett 22: 2912-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.066
BindingDB Entry DOI: 10.7270/Q2SN0B0F
More data for this
Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor


(Homo sapiens (Human))		BDBM50380813
PNG
(CHEMBL2018510)
Show SMILES Cc1cc(CC(CC(=O)N2CCC3(CC2)OC(=O)Nc2ccccc32)C(=O)N2CCC3(CC2)OCCO3)cc2cn[nH]c12
Show InChI InChI=1S/C32H37N5O6/c1-21-16-22(18-24-20-33-35-28(21)24)17-23(29(39)37-12-8-32(9-13-37)41-14-15-42-32)19-27(38)36-10-6-31(7-11-36)25-4-2-3-5-26(25)34-30(40)43-31/h2-5,16,18,20,23H,6-15,17,19H2,1H3,(H,33,35)(H,34,40)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 5.90n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting

Bioorg Med Chem Lett 22: 2912-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.066
BindingDB Entry DOI: 10.7270/Q2SN0B0F
More data for this
Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor


(Homo sapiens (Human))		BDBM50380821
PNG
(CHEMBL2018520)
Show SMILES Cc1cc(C[C@H](CC(=O)N2CCC(CC2)N2Cc3cccc(F)c3NC2=O)C(=O)N2CCC(CC2)N2CCCCC2)cc2cn[nH]c12 |r|
Show InChI InChI=1S/C36H46FN7O3/c1-24-18-25(20-28-22-38-40-33(24)28)19-27(35(46)43-16-8-29(9-17-43)41-12-3-2-4-13-41)21-32(45)42-14-10-30(11-15-42)44-23-26-6-5-7-31(37)34(26)39-36(44)47/h5-7,18,20,22,27,29-30H,2-4,8-17,19,21,23H2,1H3,(H,38,40)(H,39,47)/t27-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 6.70n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting

Bioorg Med Chem Lett 22: 2912-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.066
BindingDB Entry DOI: 10.7270/Q2SN0B0F
More data for this
Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor


(Homo sapiens (Human))		BDBM50380815
PNG
(CHEMBL2018513)
Show SMILES Cc1cc(CC(CC(=O)N2CCC(CC2)N2Cc3ccccc3NC2=O)C(=O)N2CCCCC2)cc2cn[nH]c12
Show InChI InChI=1S/C31H38N6O3/c1-21-15-22(17-25-19-32-34-29(21)25)16-24(30(39)36-11-5-2-6-12-36)18-28(38)35-13-9-26(10-14-35)37-20-23-7-3-4-8-27(23)33-31(37)40/h3-4,7-8,15,17,19,24,26H,2,5-6,9-14,16,18,20H2,1H3,(H,32,34)(H,33,40)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 6.90n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Antagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production

Bioorg Med Chem Lett 22: 2912-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.066
BindingDB Entry DOI: 10.7270/Q2SN0B0F
More data for this
Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor


(Homo sapiens (Human))		BDBM50380813
PNG
(CHEMBL2018510)
Show SMILES Cc1cc(CC(CC(=O)N2CCC3(CC2)OC(=O)Nc2ccccc32)C(=O)N2CCC3(CC2)OCCO3)cc2cn[nH]c12
Show InChI InChI=1S/C32H37N5O6/c1-21-16-22(18-24-20-33-35-28(21)24)17-23(29(39)37-12-8-32(9-13-37)41-14-15-42-32)19-27(38)36-10-6-31(7-11-36)25-4-2-3-5-26(25)34-30(40)43-31/h2-5,16,18,20,23H,6-15,17,19H2,1H3,(H,33,35)(H,34,40)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 8.80n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Antagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production

Bioorg Med Chem Lett 22: 2912-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.066
BindingDB Entry DOI: 10.7270/Q2SN0B0F
More data for this
Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor


(Homo sapiens (Human))		BDBM50380819
PNG
(CHEMBL2018518)
Show SMILES Cc1cc(C[C@H](CC(=O)N2CCC(CC2)N2Cc3ccccc3NC2=O)C(=O)N2CCC(CC2)N2CCCCC2)cc2cn[nH]c12 |r|
Show InChI InChI=1S/C36H47N7O3/c1-25-19-26(21-29-23-37-39-34(25)29)20-28(35(45)42-17-9-30(10-18-42)40-13-5-2-6-14-40)22-33(44)41-15-11-31(12-16-41)43-24-27-7-3-4-8-32(27)38-36(43)46/h3-4,7-8,19,21,23,28,30-31H,2,5-6,9-18,20,22,24H2,1H3,(H,37,39)(H,38,46)/t28-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 11n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Antagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production

Bioorg Med Chem Lett 22: 2912-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.066
BindingDB Entry DOI: 10.7270/Q2SN0B0F
More data for this
Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor


(Homo sapiens (Human))		BDBM50380819
PNG
(CHEMBL2018518)
Show SMILES Cc1cc(C[C@H](CC(=O)N2CCC(CC2)N2Cc3ccccc3NC2=O)C(=O)N2CCC(CC2)N2CCCCC2)cc2cn[nH]c12 |r|
Show InChI InChI=1S/C36H47N7O3/c1-25-19-26(21-29-23-37-39-34(25)29)20-28(35(45)42-17-9-30(10-18-42)40-13-5-2-6-14-40)22-33(44)41-15-11-31(12-16-41)43-24-27-7-3-4-8-32(27)38-36(43)46/h3-4,7-8,19,21,23,28,30-31H,2,5-6,9-18,20,22,24H2,1H3,(H,37,39)(H,38,46)/t28-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 11n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting

Bioorg Med Chem Lett 22: 2912-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.066
BindingDB Entry DOI: 10.7270/Q2SN0B0F
More data for this
Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor


(Homo sapiens (Human))		BDBM50380816
PNG
(CHEMBL2018514)
Show SMILES O=C(CC(Cc1ccc2[nH]ncc2c1)C(=O)N1CCC(CC1)N1CCCCC1)N1CCC2(CC1)OC(=O)Nc1ccccc21
Show InChI InChI=1S/C34H42N6O4/c41-31(39-18-12-34(13-19-39)28-6-2-3-7-30(28)36-33(43)44-34)22-25(20-24-8-9-29-26(21-24)23-35-37-29)32(42)40-16-10-27(11-17-40)38-14-4-1-5-15-38/h2-3,6-9,21,23,25,27H,1,4-5,10-20,22H2,(H,35,37)(H,36,43)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 15n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting

Bioorg Med Chem Lett 22: 2912-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.066
BindingDB Entry DOI: 10.7270/Q2SN0B0F
More data for this
Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor


(Homo sapiens (Human))		BDBM50380811
PNG
(CHEMBL2018512)
Show SMILES Cc1cc(CC(CC(=O)N2CCC3(CC2)OC(=O)Nc2ccccc32)C(=O)N2CCCCC2)cc2cn[nH]c12
Show InChI InChI=1S/C30H35N5O4/c1-20-15-21(17-23-19-31-33-27(20)23)16-22(28(37)35-11-5-2-6-12-35)18-26(36)34-13-9-30(10-14-34)24-7-3-4-8-25(24)32-29(38)39-30/h3-4,7-8,15,17,19,22H,2,5-6,9-14,16,18H2,1H3,(H,31,33)(H,32,38)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 19n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting

Bioorg Med Chem Lett 22: 2912-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.066
BindingDB Entry DOI: 10.7270/Q2SN0B0F
More data for this
Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor


(Homo sapiens (Human))		BDBM50380824
PNG
(CHEMBL2018494)
Show SMILES [O-][N+](=O)c1cc(Cl)ccc1N[C@@H](CC(=O)N1CCC(CC1)N1Cc2ccccc2NC1=O)C(=O)N1CCC(CC1)N1CCCCC1 |r|
Show InChI InChI=1S/C33H42ClN7O5/c34-24-8-9-28(30(20-24)41(45)46)35-29(32(43)39-18-10-25(11-19-39)37-14-4-1-5-15-37)21-31(42)38-16-12-26(13-17-38)40-22-23-6-2-3-7-27(23)36-33(40)44/h2-3,6-9,20,25-26,29,35H,1,4-5,10-19,21-22H2,(H,36,44)/t29-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 32n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting

Bioorg Med Chem Lett 22: 2912-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.066
BindingDB Entry DOI: 10.7270/Q2SN0B0F
More data for this
Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor


(Homo sapiens (Human))		BDBM50380824
PNG
(CHEMBL2018494)
Show SMILES [O-][N+](=O)c1cc(Cl)ccc1N[C@@H](CC(=O)N1CCC(CC1)N1Cc2ccccc2NC1=O)C(=O)N1CCC(CC1)N1CCCCC1 |r|
Show InChI InChI=1S/C33H42ClN7O5/c34-24-8-9-28(30(20-24)41(45)46)35-29(32(43)39-18-10-25(11-19-39)37-14-4-1-5-15-37)21-31(42)38-16-12-26(13-17-38)40-22-23-6-2-3-7-27(23)36-33(40)44/h2-3,6-9,20,25-26,29,35H,1,4-5,10-19,21-22H2,(H,36,44)/t29-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 32n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Antagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production

Bioorg Med Chem Lett 22: 2912-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.066
BindingDB Entry DOI: 10.7270/Q2SN0B0F
More data for this
Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor


(Homo sapiens (Human))		BDBM50380811
PNG
(CHEMBL2018512)
Show SMILES Cc1cc(CC(CC(=O)N2CCC3(CC2)OC(=O)Nc2ccccc32)C(=O)N2CCCCC2)cc2cn[nH]c12
Show InChI InChI=1S/C30H35N5O4/c1-20-15-21(17-23-19-31-33-27(20)23)16-22(28(37)35-11-5-2-6-12-35)18-26(36)34-13-9-30(10-14-34)24-7-3-4-8-25(24)32-29(38)39-30/h3-4,7-8,15,17,19,22H,2,5-6,9-14,16,18H2,1H3,(H,31,33)(H,32,38)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 34n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Antagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production

Bioorg Med Chem Lett 22: 2912-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.066
BindingDB Entry DOI: 10.7270/Q2SN0B0F
More data for this
Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor


(Homo sapiens (Human))		BDBM50380842
PNG
(CHEMBL2018489)
Show SMILES Clc1ccc(NC(=O)N[C@@H](CC(=O)N2CCC(CC2)N2Cc3ccccc3NC2=O)C(=O)N2CCC(CC2)N2CCCCC2)c(Cl)c1 |r|
Show InChI InChI=1S/C34H43Cl2N7O4/c35-24-8-9-29(27(36)20-24)37-33(46)38-30(32(45)42-18-10-25(11-19-42)40-14-4-1-5-15-40)21-31(44)41-16-12-26(13-17-41)43-22-23-6-2-3-7-28(23)39-34(43)47/h2-3,6-9,20,25-26,30H,1,4-5,10-19,21-22H2,(H,39,47)(H2,37,38,46)/t30-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 36n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting

Bioorg Med Chem Lett 22: 2912-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.066
BindingDB Entry DOI: 10.7270/Q2SN0B0F
More data for this
Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor


(Homo sapiens (Human))		BDBM50380843
PNG
(CHEMBL2018490)
Show SMILES Fc1ccccc1NC(=O)N[C@@H](CC(=O)N1CCC(CC1)N1Cc2ccccc2NC1=O)C(=O)N1CCC(CC1)N1CCCCC1 |r|
Show InChI InChI=1S/C34H44FN7O4/c35-27-9-3-5-11-29(27)36-33(45)37-30(32(44)41-20-12-25(13-21-41)39-16-6-1-7-17-39)22-31(43)40-18-14-26(15-19-40)42-23-24-8-2-4-10-28(24)38-34(42)46/h2-5,8-11,25-26,30H,1,6-7,12-23H2,(H,38,46)(H2,36,37,45)/t30-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 45n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting

Bioorg Med Chem Lett 22: 2912-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.066
BindingDB Entry DOI: 10.7270/Q2SN0B0F
More data for this
Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor


(Homo sapiens (Human))		BDBM50380810
PNG
(CHEMBL2018492)
Show SMILES Clc1cc(N[C@@H](CC(=O)N2CCC(CC2)N2Cc3ccccc3NC2=O)C(=O)N2CCC(CC2)N2CCCCC2)ncn1 |r|
Show InChI InChI=1S/C31H41ClN8O3/c32-27-19-28(34-21-33-27)35-26(30(42)39-16-8-23(9-17-39)37-12-4-1-5-13-37)18-29(41)38-14-10-24(11-15-38)40-20-22-6-2-3-7-25(22)36-31(40)43/h2-3,6-7,19,21,23-24,26H,1,4-5,8-18,20H2,(H,36,43)(H,33,34,35)/t26-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 46n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Antagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production

Bioorg Med Chem Lett 22: 2912-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.066
BindingDB Entry DOI: 10.7270/Q2SN0B0F
More data for this
Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor


(Homo sapiens (Human))		BDBM50380816
PNG
(CHEMBL2018514)
Show SMILES O=C(CC(Cc1ccc2[nH]ncc2c1)C(=O)N1CCC(CC1)N1CCCCC1)N1CCC2(CC1)OC(=O)Nc1ccccc21
Show InChI InChI=1S/C34H42N6O4/c41-31(39-18-12-34(13-19-39)28-6-2-3-7-30(28)36-33(43)44-34)22-25(20-24-8-9-29-26(21-24)23-35-37-29)32(42)40-16-10-27(11-17-40)38-14-4-1-5-15-38/h2-3,6-9,21,23,25,27H,1,4-5,10-20,22H2,(H,35,37)(H,36,43)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 53n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Antagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production

Bioorg Med Chem Lett 22: 2912-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.066
BindingDB Entry DOI: 10.7270/Q2SN0B0F
More data for this
Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor


(Homo sapiens (Human))		BDBM50380827
PNG
(CHEMBL2018498)
Show SMILES O=C(C[C@H](Nc1ccc2[nH]ccc2c1)C(=O)N1CCC(CC1)N1CCCCC1)N1CCC(CC1)N1Cc2ccccc2NC1=O |r|
Show InChI InChI=1S/C35H45N7O3/c43-33(40-18-13-29(14-19-40)42-24-26-6-2-3-7-31(26)38-35(42)45)23-32(37-27-8-9-30-25(22-27)10-15-36-30)34(44)41-20-11-28(12-21-41)39-16-4-1-5-17-39/h2-3,6-10,15,22,28-29,32,36-37H,1,4-5,11-14,16-21,23-24H2,(H,38,45)/t32-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 59n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Antagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production

Bioorg Med Chem Lett 22: 2912-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.066
BindingDB Entry DOI: 10.7270/Q2SN0B0F
More data for this
Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor


(Homo sapiens (Human))		BDBM50380826
PNG
(CHEMBL2018497)
Show SMILES Cc1nc(N[C@@H](CC(=O)N2CCC(CC2)N2Cc3ccccc3NC2=O)C(=O)N2CCC(CC2)N2CCCCC2)nc2nn[nH]c12 |r|
Show InChI InChI=1S/C32H43N11O3/c1-21-28-29(38-39-37-28)36-31(33-21)34-26(30(45)42-17-9-23(10-18-42)40-13-5-2-6-14-40)19-27(44)41-15-11-24(12-16-41)43-20-22-7-3-4-8-25(22)35-32(43)46/h3-4,7-8,23-24,26H,2,5-6,9-20H2,1H3,(H,35,46)(H2,33,34,36,37,38,39)/t26-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 73n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting

Bioorg Med Chem Lett 22: 2912-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.066
BindingDB Entry DOI: 10.7270/Q2SN0B0F
More data for this
Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor


(Homo sapiens (Human))		BDBM50380845
PNG
(CHEMBL2018496)
Show SMILES Cc1nc(N[C@@H](CC(=O)N2CCC(CC2)N2Cc3ccccc3NC2=O)C(=O)N2CCC(CC2)N2CCCCC2)nc(N)c1[N+]([O-])=O |r|
Show InChI InChI=1S/C32H44N10O5/c1-21-28(42(46)47)29(33)37-31(34-21)35-26(30(44)40-17-9-23(10-18-40)38-13-5-2-6-14-38)19-27(43)39-15-11-24(12-16-39)41-20-22-7-3-4-8-25(22)36-32(41)45/h3-4,7-8,23-24,26H,2,5-6,9-20H2,1H3,(H,36,45)(H3,33,34,35,37)/t26-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 80n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting

Bioorg Med Chem Lett 22: 2912-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.066
BindingDB Entry DOI: 10.7270/Q2SN0B0F
More data for this
Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor


(Homo sapiens (Human))		BDBM50380817
PNG
(CHEMBL2018515)
Show SMILES O=C(CC(Cc1ccc2[nH]ncc2c1)C(=O)N1CCC2(CC1)OCCO2)N1CCC(CC1)N1Cc2ccccc2NC1=O
Show InChI InChI=1S/C32H38N6O5/c39-29(36-11-7-26(8-12-36)38-21-23-3-1-2-4-27(23)34-31(38)41)19-24(17-22-5-6-28-25(18-22)20-33-35-28)30(40)37-13-9-32(10-14-37)42-15-16-43-32/h1-6,18,20,24,26H,7-17,19,21H2,(H,33,35)(H,34,41)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 87n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting

Bioorg Med Chem Lett 22: 2912-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.066
BindingDB Entry DOI: 10.7270/Q2SN0B0F
More data for this
Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor


(Homo sapiens (Human))		BDBM50380841
PNG
(CHEMBL2018488)
Show SMILES Clc1cccc(NC(=O)N[C@@H](CC(=O)N2CCC(CC2)N2Cc3ccccc3NC2=O)C(=O)N2CCC(CC2)N2CCCCC2)c1Cl |r|
Show InChI InChI=1S/C34H43Cl2N7O4/c35-26-8-6-10-28(31(26)36)37-33(46)38-29(32(45)42-19-11-24(12-20-42)40-15-4-1-5-16-40)21-30(44)41-17-13-25(14-18-41)43-22-23-7-2-3-9-27(23)39-34(43)47/h2-3,6-10,24-25,29H,1,4-5,11-22H2,(H,39,47)(H2,37,38,46)/t29-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 97n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting

Bioorg Med Chem Lett 22: 2912-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.066
BindingDB Entry DOI: 10.7270/Q2SN0B0F
More data for this
Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor


(Homo sapiens (Human))		BDBM50380810
PNG
(CHEMBL2018492)
Show SMILES Clc1cc(N[C@@H](CC(=O)N2CCC(CC2)N2Cc3ccccc3NC2=O)C(=O)N2CCC(CC2)N2CCCCC2)ncn1 |r|
Show InChI InChI=1S/C31H41ClN8O3/c32-27-19-28(34-21-33-27)35-26(30(42)39-16-8-23(9-17-39)37-12-4-1-5-13-37)18-29(41)38-14-10-24(11-15-38)40-20-22-6-2-3-7-25(22)36-31(40)43/h2-3,6-7,19,21,23-24,26H,1,4-5,8-18,20H2,(H,36,43)(H,33,34,35)/t26-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 98n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting

Bioorg Med Chem Lett 22: 2912-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.066
BindingDB Entry DOI: 10.7270/Q2SN0B0F
More data for this
Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor


(Homo sapiens (Human))		BDBM50380825
PNG
(CHEMBL2018495)
Show SMILES Clc1nc(N[C@@H](CC(=O)N2CCC(CC2)N2Cc3ccccc3NC2=O)C(=O)N2CCC(CC2)N2CCCCC2)c2c[nH]nc2n1 |r|
Show InChI InChI=1S/C32H41ClN10O3/c33-31-37-28(24-19-34-39-29(24)38-31)35-26(30(45)42-16-8-22(9-17-42)40-12-4-1-5-13-40)18-27(44)41-14-10-23(11-15-41)43-20-21-6-2-3-7-25(21)36-32(43)46/h2-3,6-7,19,22-23,26H,1,4-5,8-18,20H2,(H,36,46)(H2,34,35,37,38,39)/t26-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 99n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Antagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production

Bioorg Med Chem Lett 22: 2912-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.066
BindingDB Entry DOI: 10.7270/Q2SN0B0F
More data for this
Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor


(Homo sapiens (Human))		BDBM50380823
PNG
(CHEMBL2018491)
Show SMILES Clc1ccccc1NC(=O)N[C@@H](CC(=O)N1CCC(CC1)N1Cc2ccccc2NC1=O)C(=O)N1CCC(CC1)N1CCCCC1 |r|
Show InChI InChI=1S/C34H44ClN7O4/c35-27-9-3-5-11-29(27)36-33(45)37-30(32(44)41-20-12-25(13-21-41)39-16-6-1-7-17-39)22-31(43)40-18-14-26(15-19-40)42-23-24-8-2-4-10-28(24)38-34(42)46/h2-5,8-11,25-26,30H,1,6-7,12-23H2,(H,38,46)(H2,36,37,45)/t30-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 100n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Antagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production

Bioorg Med Chem Lett 22: 2912-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.066
BindingDB Entry DOI: 10.7270/Q2SN0B0F
More data for this
Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor


(Homo sapiens (Human))		BDBM50380847
PNG
(CHEMBL2018501)
Show SMILES Brc1ccc(N[C@@H](CC(=O)N2CCC(CC2)N2Cc3ccccc3NC2=O)C(=O)N2CCC(CC2)N2CCCCC2)c2ccccc12 |r|
Show InChI InChI=1S/C37H45BrN6O3/c38-31-12-13-33(30-10-4-3-9-29(30)31)39-34(36(46)43-22-14-27(15-23-43)41-18-6-1-7-19-41)24-35(45)42-20-16-28(17-21-42)44-25-26-8-2-5-11-32(26)40-37(44)47/h2-5,8-13,27-28,34,39H,1,6-7,14-25H2,(H,40,47)/t34-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 120n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting

Bioorg Med Chem Lett 22: 2912-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.066
BindingDB Entry DOI: 10.7270/Q2SN0B0F
More data for this
Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor


(Homo sapiens (Human))		BDBM50380826
PNG
(CHEMBL2018497)
Show SMILES Cc1nc(N[C@@H](CC(=O)N2CCC(CC2)N2Cc3ccccc3NC2=O)C(=O)N2CCC(CC2)N2CCCCC2)nc2nn[nH]c12 |r|
Show InChI InChI=1S/C32H43N11O3/c1-21-28-29(38-39-37-28)36-31(33-21)34-26(30(45)42-17-9-23(10-18-42)40-13-5-2-6-14-40)19-27(44)41-15-11-24(12-16-41)43-20-22-7-3-4-8-25(22)35-32(43)46/h3-4,7-8,23-24,26H,2,5-6,9-20H2,1H3,(H,35,46)(H2,33,34,36,37,38,39)/t26-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 120n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Antagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production

Bioorg Med Chem Lett 22: 2912-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.066
BindingDB Entry DOI: 10.7270/Q2SN0B0F
More data for this
Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor


(Homo sapiens (Human))		BDBM50380822
PNG
(CHEMBL2018356)
Show SMILES O=C(C[C@H](NCc1ccc2[nH]ncc2c1)C(=O)N1CCC(CC1)N1CCCCC1)N1CCC(CC1)N1Cc2ccccc2NC1=O |r|
Show InChI InChI=1S/C35H46N8O3/c44-33(41-16-12-29(13-17-41)43-24-26-6-2-3-7-30(26)38-35(43)46)21-32(36-22-25-8-9-31-27(20-25)23-37-39-31)34(45)42-18-10-28(11-19-42)40-14-4-1-5-15-40/h2-3,6-9,20,23,28-29,32,36H,1,4-5,10-19,21-22,24H2,(H,37,39)(H,38,46)/t32-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 130n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting

Bioorg Med Chem Lett 22: 2912-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.066
BindingDB Entry DOI: 10.7270/Q2SN0B0F
More data for this
Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor


(Homo sapiens (Human))		BDBM50380828
PNG
(CHEMBL2018499)
Show SMILES O=C(C[C@H](Nc1ccc2[nH]ncc2c1)C(=O)N1CCC(CC1)N1CCCCC1)N1CCC(CC1)N1Cc2ccccc2NC1=O |r|
Show InChI InChI=1S/C34H44N8O3/c43-32(40-16-12-28(13-17-40)42-23-24-6-2-3-7-29(24)37-34(42)45)21-31(36-26-8-9-30-25(20-26)22-35-38-30)33(44)41-18-10-27(11-19-41)39-14-4-1-5-15-39/h2-3,6-9,20,22,27-28,31,36H,1,4-5,10-19,21,23H2,(H,35,38)(H,37,45)/t31-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 170n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting

Bioorg Med Chem Lett 22: 2912-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.066
BindingDB Entry DOI: 10.7270/Q2SN0B0F
More data for this
Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor


(Homo sapiens (Human))		BDBM50380827
PNG
(CHEMBL2018498)
Show SMILES O=C(C[C@H](Nc1ccc2[nH]ccc2c1)C(=O)N1CCC(CC1)N1CCCCC1)N1CCC(CC1)N1Cc2ccccc2NC1=O |r|
Show InChI InChI=1S/C35H45N7O3/c43-33(40-18-13-29(14-19-40)42-24-26-6-2-3-7-31(26)38-35(42)45)23-32(37-27-8-9-30-25(22-27)10-15-36-30)34(44)41-20-11-28(12-21-41)39-16-4-1-5-17-39/h2-3,6-10,15,22,28-29,32,36-37H,1,4-5,11-14,16-21,23-24H2,(H,38,45)/t32-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 180n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting

Bioorg Med Chem Lett 22: 2912-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.066
BindingDB Entry DOI: 10.7270/Q2SN0B0F
More data for this
Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor


(Homo sapiens (Human))		BDBM50380848
PNG
(CHEMBL2018502)
Show SMILES O=C(C[C@H](Nc1cccc2ccccc12)C(=O)N1CCC(CC1)N1CCCCC1)N1CCC(CC1)N1Cc2ccccc2NC1=O |r|
Show InChI InChI=1S/C37H46N6O3/c44-35(41-21-17-30(18-22-41)43-26-28-10-3-5-13-32(28)39-37(43)46)25-34(38-33-14-8-11-27-9-2-4-12-31(27)33)36(45)42-23-15-29(16-24-42)40-19-6-1-7-20-40/h2-5,8-14,29-30,34,38H,1,6-7,15-26H2,(H,39,46)/t34-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 220n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting

Bioorg Med Chem Lett 22: 2912-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.066
BindingDB Entry DOI: 10.7270/Q2SN0B0F
More data for this
Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor


(Homo sapiens (Human))		BDBM50380828
PNG
(CHEMBL2018499)
Show SMILES O=C(C[C@H](Nc1ccc2[nH]ncc2c1)C(=O)N1CCC(CC1)N1CCCCC1)N1CCC(CC1)N1Cc2ccccc2NC1=O |r|
Show InChI InChI=1S/C34H44N8O3/c43-32(40-16-12-28(13-17-40)42-23-24-6-2-3-7-29(24)37-34(42)45)21-31(36-26-8-9-30-25(20-26)22-35-38-30)33(44)41-18-10-27(11-19-41)39-14-4-1-5-15-39/h2-3,6-9,20,22,27-28,31,36H,1,4-5,10-19,21,23H2,(H,35,38)(H,37,45)/t31-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 230n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Antagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production

Bioorg Med Chem Lett 22: 2912-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.066
BindingDB Entry DOI: 10.7270/Q2SN0B0F
More data for this
Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor


(Homo sapiens (Human))		BDBM50380825
PNG
(CHEMBL2018495)
Show SMILES Clc1nc(N[C@@H](CC(=O)N2CCC(CC2)N2Cc3ccccc3NC2=O)C(=O)N2CCC(CC2)N2CCCCC2)c2c[nH]nc2n1 |r|
Show InChI InChI=1S/C32H41ClN10O3/c33-31-37-28(24-19-34-39-29(24)38-31)35-26(30(45)42-16-8-22(9-17-42)40-12-4-1-5-13-40)18-27(44)41-14-10-23(11-15-41)43-20-21-6-2-3-7-25(21)36-32(43)46/h2-3,6-7,19,22-23,26H,1,4-5,8-18,20H2,(H,36,46)(H2,34,35,37,38,39)/t26-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 250n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting

Bioorg Med Chem Lett 22: 2912-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.066
BindingDB Entry DOI: 10.7270/Q2SN0B0F
More data for this
Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor


(Homo sapiens (Human))		BDBM50380840
PNG
(CHEMBL2018487)
Show SMILES O=C(N[C@@H](CC(=O)N1CCC(CC1)N1Cc2ccccc2NC1=O)C(=O)N1CCC(CC1)N1CCCCC1)Oc1ccccc1 |r|
Show InChI InChI=1S/C34H44N6O5/c41-31(38-19-15-27(16-20-38)40-24-25-9-5-6-12-29(25)35-33(40)43)23-30(36-34(44)45-28-10-3-1-4-11-28)32(42)39-21-13-26(14-22-39)37-17-7-2-8-18-37/h1,3-6,9-12,26-27,30H,2,7-8,13-24H2,(H,35,43)(H,36,44)/t30-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 280n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting

Bioorg Med Chem Lett 22: 2912-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.066
BindingDB Entry DOI: 10.7270/Q2SN0B0F
More data for this
Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor


(Homo sapiens (Human))		BDBM50380822
PNG
(CHEMBL2018356)
Show SMILES O=C(C[C@H](NCc1ccc2[nH]ncc2c1)C(=O)N1CCC(CC1)N1CCCCC1)N1CCC(CC1)N1Cc2ccccc2NC1=O |r|
Show InChI InChI=1S/C35H46N8O3/c44-33(41-16-12-29(13-17-41)43-24-26-6-2-3-7-30(26)38-35(43)46)21-32(36-22-25-8-9-31-27(20-25)23-37-39-31)34(45)42-18-10-28(11-19-42)40-14-4-1-5-15-40/h2-3,6-9,20,23,28-29,32,36H,1,4-5,10-19,21-22,24H2,(H,37,39)(H,38,46)/t32-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 300n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Antagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production

Bioorg Med Chem Lett 22: 2912-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.066
BindingDB Entry DOI: 10.7270/Q2SN0B0F
More data for this
Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor


(Homo sapiens (Human))		BDBM50380817
PNG
(CHEMBL2018515)
Show SMILES O=C(CC(Cc1ccc2[nH]ncc2c1)C(=O)N1CCC2(CC1)OCCO2)N1CCC(CC1)N1Cc2ccccc2NC1=O
Show InChI InChI=1S/C32H38N6O5/c39-29(36-11-7-26(8-12-36)38-21-23-3-1-2-4-27(23)34-31(38)41)19-24(17-22-5-6-28-25(18-22)20-33-35-28)30(40)37-13-9-32(10-14-37)42-15-16-43-32/h1-6,18,20,24,26H,7-17,19,21H2,(H,33,35)(H,34,41)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 320n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Antagonist activity at human CGRP receptor expressed in human SK-N-MC cells assessed as inhibition of CGRP-stimulated cAMP production

Bioorg Med Chem Lett 22: 2912-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.066
BindingDB Entry DOI: 10.7270/Q2SN0B0F
More data for this
Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor


(Homo sapiens (Human))		BDBM50380836
PNG
(CHEMBL2018355)
Show SMILES O=C(C[C@H](NCc1ccc2[nH]ccc2c1)C(=O)N1CCC(CC1)N1CCCCC1)N1CCC(CC1)N1Cc2ccccc2NC1=O |r|
Show InChI InChI=1S/C36H47N7O3/c44-34(41-18-13-30(14-19-41)43-25-28-6-2-3-7-32(28)39-36(43)46)23-33(38-24-26-8-9-31-27(22-26)10-15-37-31)35(45)42-20-11-29(12-21-42)40-16-4-1-5-17-40/h2-3,6-10,15,22,29-30,33,37-38H,1,4-5,11-14,16-21,23-25H2,(H,39,46)/t33-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 380n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting

Bioorg Med Chem Lett 22: 2912-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.066
BindingDB Entry DOI: 10.7270/Q2SN0B0F
More data for this
Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor


(Homo sapiens (Human))		BDBM50380838
PNG
(CHEMBL2018358)
Show SMILES Fc1ccc(cc1F)C(=O)N[C@@H](CC(=O)N1CCC(CC1)N1Cc2ccccc2NC1=O)C(=O)N1CCC(CC1)N1CCCCC1 |r|
Show InChI InChI=1S/C34H42F2N6O4/c35-27-9-8-23(20-28(27)36)32(44)37-30(33(45)41-18-10-25(11-19-41)39-14-4-1-5-15-39)21-31(43)40-16-12-26(13-17-40)42-22-24-6-2-3-7-29(24)38-34(42)46/h2-3,6-9,20,25-26,30H,1,4-5,10-19,21-22H2,(H,37,44)(H,38,46)/t30-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 430n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting

Bioorg Med Chem Lett 22: 2912-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.066
BindingDB Entry DOI: 10.7270/Q2SN0B0F
More data for this
Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor


(Homo sapiens (Human))		BDBM50380818
PNG
(CHEMBL2018516)
Show SMILES O=C(CC(Cc1ccc2[nH]ncc2c1)C(=O)N1CCC2(CC1)OCCO2)N1CCC2(CC1)OC(=O)Nc1ccccc21
Show InChI InChI=1S/C31H35N5O6/c37-27(35-11-7-30(8-12-35)24-3-1-2-4-26(24)33-29(39)42-30)19-22(17-21-5-6-25-23(18-21)20-32-34-25)28(38)36-13-9-31(10-14-36)40-15-16-41-31/h1-6,18,20,22H,7-17,19H2,(H,32,34)(H,33,39)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 460n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting

Bioorg Med Chem Lett 22: 2912-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.066
BindingDB Entry DOI: 10.7270/Q2SN0B0F
More data for this
Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor


(Homo sapiens (Human))		BDBM50380839
PNG
(CHEMBL2018359)
Show SMILES CC(C)(C)OC(=O)N[C@@H](CC(=O)N1CCC(CC1)N1Cc2ccccc2NC1=O)C(=O)N1CCC(CC1)N1CCCCC1 |r|
Show InChI InChI=1S/C32H48N6O5/c1-32(2,3)43-31(42)34-27(29(40)37-19-11-24(12-20-37)35-15-7-4-8-16-35)21-28(39)36-17-13-25(14-18-36)38-22-23-9-5-6-10-26(23)33-30(38)41/h5-6,9-10,24-25,27H,4,7-8,11-22H2,1-3H3,(H,33,41)(H,34,42)/t27-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 590n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting

Bioorg Med Chem Lett 22: 2912-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.066
BindingDB Entry DOI: 10.7270/Q2SN0B0F
More data for this
Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor


(Homo sapiens (Human))		BDBM50380835
PNG
(CHEMBL2018354)
Show SMILES O=C(C[C@H](NCc1ccccn1)C(=O)N1CCC(CC1)N1CCCCC1)N1CCC(CC1)N1Cc2ccccc2NC1=O |r|
Show InChI InChI=1S/C33H45N7O3/c41-31(38-18-13-28(14-19-38)40-24-25-8-2-3-10-29(25)36-33(40)43)22-30(35-23-26-9-4-5-15-34-26)32(42)39-20-11-27(12-21-39)37-16-6-1-7-17-37/h2-5,8-10,15,27-28,30,35H,1,6-7,11-14,16-24H2,(H,36,43)/t30-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 700n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting

Bioorg Med Chem Lett 22: 2912-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.066
BindingDB Entry DOI: 10.7270/Q2SN0B0F
More data for this
Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor


(Homo sapiens (Human))		BDBM50380846
PNG
(CHEMBL2018500)
Show SMILES O=C(C[C@H](Nc1cccc2ncccc12)C(=O)N1CCC(CC1)N1CCCCC1)N1CCC(CC1)N1Cc2ccccc2NC1=O |r|
Show InChI InChI=1S/C36H45N7O3/c44-34(41-20-15-28(16-21-41)43-25-26-8-2-3-10-30(26)39-36(43)46)24-33(38-32-12-6-11-31-29(32)9-7-17-37-31)35(45)42-22-13-27(14-23-42)40-18-4-1-5-19-40/h2-3,6-12,17,27-28,33,38H,1,4-5,13-16,18-25H2,(H,39,46)/t33-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 890n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting

Bioorg Med Chem Lett 22: 2912-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.066
BindingDB Entry DOI: 10.7270/Q2SN0B0F
More data for this
Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor


(Homo sapiens (Human))		BDBM50380844
PNG
(CHEMBL2018493)
Show SMILES O=C(C[C@H](Nc1ccncn1)C(=O)N1CCC(CC1)N1CCCCC1)N1CCC(CC1)N1Cc2ccccc2NC1=O |r|
Show InChI InChI=1S/C31H42N8O3/c40-29(37-16-11-25(12-17-37)39-21-23-6-2-3-7-26(23)35-31(39)42)20-27(34-28-8-13-32-22-33-28)30(41)38-18-9-24(10-19-38)36-14-4-1-5-15-36/h2-3,6-8,13,22,24-25,27H,1,4-5,9-12,14-21H2,(H,35,42)(H,32,33,34)/t27-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.40E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting

Bioorg Med Chem Lett 22: 2912-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.066
BindingDB Entry DOI: 10.7270/Q2SN0B0F
More data for this
Ligand-Target Pair
Calcitonin gene-related peptide type 1 receptor


(Homo sapiens (Human))		BDBM50380837
PNG
(CHEMBL2018357)
Show SMILES OC1CCC(CC1)N[C@@H](CC(=O)N1CCC(CC1)N1Cc2ccccc2NC1=O)C(=O)N1CCC(CC1)N1CCCCC1 |r,wD:8.8,(-12.97,-22.44,;-11.62,-21.68,;-11.62,-20.14,;-10.28,-19.38,;-8.95,-20.16,;-8.94,-21.69,;-10.29,-22.46,;-7.61,-19.39,;-7.61,-17.85,;-6.27,-17.08,;-4.93,-17.83,;-4.9,-19.37,;-3.61,-17.03,;-2.26,-17.79,;-.94,-17,;-.96,-15.46,;-2.31,-14.71,;-3.64,-15.5,;.36,-14.67,;1.7,-15.43,;3.02,-14.64,;4.35,-15.4,;5.67,-14.62,;5.66,-13.08,;4.32,-12.33,;3.01,-13.11,;1.66,-12.35,;.33,-13.14,;-1.01,-12.39,;-8.94,-17.08,;-10.28,-17.84,;-8.94,-15.53,;-7.6,-14.78,;-7.6,-13.24,;-8.93,-12.46,;-10.26,-13.23,;-10.27,-14.76,;-8.93,-10.92,;-7.59,-10.16,;-7.58,-8.62,;-8.91,-7.84,;-10.25,-8.61,;-10.26,-10.15,)|
Show InChI InChI=1S/C33H50N6O4/c40-28-10-8-25(9-11-28)34-30(32(42)38-20-12-26(13-21-38)36-16-4-1-5-17-36)22-31(41)37-18-14-27(15-19-37)39-23-24-6-2-3-7-29(24)35-33(39)43/h2-3,6-7,25-28,30,34,40H,1,4-5,8-23H2,(H,35,43)/t25?,28?,30-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 4.50E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting

Bioorg Med Chem Lett 22: 2912-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.066
BindingDB Entry DOI: 10.7270/Q2SN0B0F
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%