Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cellular tumor antigen p53 (Homo sapiens (Human)) | BDBM50388626 (CHEMBL2059435 | US9296736, 152 | US9593129, Exampl...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL MCE MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 760 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc. Curated by ChEMBL | Assay Description Activity at p53 in human SJSA1 cells assessed as induction of p21 mRNA expression after 7 hrs by qRT-PCR analysis in presence of 10% human serum | J Med Chem 55: 4936-54 (2012) Article DOI: 10.1021/jm300354j BindingDB Entry DOI: 10.7270/Q2S75HGJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cellular tumor antigen p53 (Homo sapiens (Human)) | BDBM50397771 (CHEMBL2059300 | US9593129, Example 67) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc. Curated by ChEMBL | Assay Description Activity at p53 in human HCT116 cells expressing wild type p53 assessed as induction of p21 mRNA expression after 7 hrs by RT-PCR analysis | J Med Chem 55: 4936-54 (2012) Article DOI: 10.1021/jm300354j BindingDB Entry DOI: 10.7270/Q2S75HGJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cellular tumor antigen p53 (Homo sapiens (Human)) | BDBM50397772 (CHEMBL2177191 | US9296736, 185 | US9593129, Exampl...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc. Curated by ChEMBL | Assay Description Activity at p53 in human SJSA1 cells assessed as induction of p21 mRNA expression after 7 hrs by qRT-PCR analysis in presence of 10% human serum | J Med Chem 55: 4936-54 (2012) Article DOI: 10.1021/jm300354j BindingDB Entry DOI: 10.7270/Q2S75HGJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cellular tumor antigen p53 (Homo sapiens (Human)) | BDBM50397774 (CHEMBL2177189 | US9296736, 128) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc. Curated by ChEMBL | Assay Description Activity at p53 in human SJSA1 cells assessed as induction of p21 mRNA expression after 7 hrs by qRT-PCR analysis in presence of 10% human serum | J Med Chem 55: 4936-54 (2012) Article DOI: 10.1021/jm300354j BindingDB Entry DOI: 10.7270/Q2S75HGJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cellular tumor antigen p53 (Homo sapiens (Human)) | BDBM50397771 (CHEMBL2059300 | US9593129, Example 67) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc. Curated by ChEMBL | Assay Description Activity at p53 in human SJSA1 cells assessed as induction of p21 mRNA expression after 7 hrs by qRT-PCR analysis in presence of 10% human serum | J Med Chem 55: 4936-54 (2012) Article DOI: 10.1021/jm300354j BindingDB Entry DOI: 10.7270/Q2S75HGJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cellular tumor antigen p53 (Homo sapiens (Human)) | BDBM50397775 (CHEMBL2177188) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc. Curated by ChEMBL | Assay Description Activity at p53 in human SJSA1 cells assessed as induction of p21 mRNA expression after 7 hrs by qRT-PCR analysis in presence of 10% human serum | J Med Chem 55: 4936-54 (2012) Article DOI: 10.1021/jm300354j BindingDB Entry DOI: 10.7270/Q2S75HGJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cellular tumor antigen p53 (Homo sapiens (Human)) | BDBM50397776 (CHEMBL2177187 | US9593129, Example 1) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 4.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc. Curated by ChEMBL | Assay Description Activity at p53 in human SJSA1 cells assessed as induction of p21 mRNA expression after 7 hrs by qRT-PCR analysis in presence of 10% human serum | J Med Chem 55: 4936-54 (2012) Article DOI: 10.1021/jm300354j BindingDB Entry DOI: 10.7270/Q2S75HGJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cellular tumor antigen p53 (Homo sapiens (Human)) | BDBM50397773 (CHEMBL2177190) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc. Curated by ChEMBL | Assay Description Activity at p53 in human SJSA1 cells assessed as induction of p21 mRNA expression after 7 hrs by qRT-PCR analysis in presence of 10% human serum | J Med Chem 55: 4936-54 (2012) Article DOI: 10.1021/jm300354j BindingDB Entry DOI: 10.7270/Q2S75HGJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cellular tumor antigen p53 (Homo sapiens (Human)) | BDBM50229787 ((4S,5R)-Nutlin-3 | (rac)-(4,5-bis(4-chlorophenyl)-...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 7.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc. Curated by ChEMBL | Assay Description Activity at p53 in human SJSA1 cells assessed as induction of p21 mRNA expression after 7 hrs by qRT-PCR analysis in presence of 10% human serum | J Med Chem 55: 4936-54 (2012) Article DOI: 10.1021/jm300354j BindingDB Entry DOI: 10.7270/Q2S75HGJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cellular tumor antigen p53 (Homo sapiens (Human)) | BDBM50397777 (CHEMBL2177186 | US9593129, Example 3) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.07E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc. Curated by ChEMBL | Assay Description Activity at p53 in human SJSA1 cells assessed as induction of p21 mRNA expression after 7 hrs by qRT-PCR analysis in presence of 10% human serum | J Med Chem 55: 4936-54 (2012) Article DOI: 10.1021/jm300354j BindingDB Entry DOI: 10.7270/Q2S75HGJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cellular tumor antigen p53 (Homo sapiens (Human)) | BDBM50397778 (CHEMBL2177813 | US9593129, Example 35) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 3.44E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc. Curated by ChEMBL | Assay Description Activity at p53 in human SJSA1 cells assessed as induction of p21 mRNA expression after 7 hrs by qRT-PCR analysis in presence of 10% human serum | J Med Chem 55: 4936-54 (2012) Article DOI: 10.1021/jm300354j BindingDB Entry DOI: 10.7270/Q2S75HGJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human)) | BDBM50388626 (CHEMBL2059435 | US9296736, 152 | US9593129, Exampl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL MCE MMDB PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a |
Amgen Inc. Curated by ChEMBL | Assay Description Binding affinity to human MDM2 by SPR analysis | J Med Chem 55: 4936-54 (2012) Article DOI: 10.1021/jm300354j BindingDB Entry DOI: 10.7270/Q2S75HGJ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human)) | BDBM50397771 (CHEMBL2059300 | US9593129, Example 67) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a |
Amgen Inc. Curated by ChEMBL | Assay Description Binding affinity to human MDM2 by SPR analysis | J Med Chem 55: 4936-54 (2012) Article DOI: 10.1021/jm300354j BindingDB Entry DOI: 10.7270/Q2S75HGJ | |||||||||||
More data for this Ligand-Target Pair |