Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sphingolipid delta(4)-desaturase DES1 (Homo sapiens (Human)) | BDBM50382314 (CHEMBL2024680) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.81E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Advanced Chemistry of Catalonia Curated by ChEMBL | Assay Description Inhibition of Des1 in human A549 cells assessed as formation of CerC6NBD from dhCerC6NBD after 4 hrs by HPLC-FD analysis | Bioorg Med Chem 20: 3173-9 (2012) Article DOI: 10.1016/j.bmc.2012.03.073 BindingDB Entry DOI: 10.7270/Q2V40W7N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sphingolipid delta(4)-desaturase DES1 (Homo sapiens (Human)) | BDBM50382314 (CHEMBL2024680) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.88E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Advanced Chemistry of Catalonia Curated by ChEMBL | Assay Description Inhibition of Des1 in human HCT116 cells assessed as formation of CerC6NBD from dhCerC6NBD after 4 hrs by HPLC-FD analysis | Bioorg Med Chem 20: 3173-9 (2012) Article DOI: 10.1016/j.bmc.2012.03.073 BindingDB Entry DOI: 10.7270/Q2V40W7N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acid ceramidase (Homo sapiens (Human)) | BDBM50382315 (CHEMBL2024682) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Advanced Chemistry of Catalonia Curated by ChEMBL | Assay Description Inhibition of aCDase in Moh.pAS AcCer10X cells using RBM14C12 as substrate after 1 hr by HPLC-FD analysis | Bioorg Med Chem 20: 3173-9 (2012) Article DOI: 10.1016/j.bmc.2012.03.073 BindingDB Entry DOI: 10.7270/Q2V40W7N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acid ceramidase (Homo sapiens (Human)) | BDBM50382315 (CHEMBL2024682) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Advanced Chemistry of Catalonia Curated by ChEMBL | Assay Description Inhibition of aCDase using RBM14C12 as substrate after 1 hr by HPLC-FD analysis | Bioorg Med Chem 20: 3173-9 (2012) Article DOI: 10.1016/j.bmc.2012.03.073 BindingDB Entry DOI: 10.7270/Q2V40W7N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acid ceramidase (Homo sapiens (Human)) | BDBM50382314 (CHEMBL2024680) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 7.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Advanced Chemistry of Catalonia Curated by ChEMBL | Assay Description Inhibition of aCDase using RBM14C12 as substrate after 1 hr by HPLC-FD analysis | Bioorg Med Chem 20: 3173-9 (2012) Article DOI: 10.1016/j.bmc.2012.03.073 BindingDB Entry DOI: 10.7270/Q2V40W7N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acid ceramidase (Homo sapiens (Human)) | BDBM50382314 (CHEMBL2024680) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 7.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Advanced Chemistry of Catalonia Curated by ChEMBL | Assay Description Inhibition of aCDase in Moh.pAS AcCer10X cells using RBM14C12 as substrate after 1 hr by HPLC-FD analysis | Bioorg Med Chem 20: 3173-9 (2012) Article DOI: 10.1016/j.bmc.2012.03.073 BindingDB Entry DOI: 10.7270/Q2V40W7N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acid ceramidase (Homo sapiens (Human)) | BDBM50382316 (CHEMBL2024681) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.15E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Advanced Chemistry of Catalonia Curated by ChEMBL | Assay Description Inhibition of aCDase in Moh.pAS AcCer10X cells using RBM14C12 as substrate after 1 hr by HPLC-FD analysis | Bioorg Med Chem 20: 3173-9 (2012) Article DOI: 10.1016/j.bmc.2012.03.073 BindingDB Entry DOI: 10.7270/Q2V40W7N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acid ceramidase (Homo sapiens (Human)) | BDBM50382316 (CHEMBL2024681) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.15E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Advanced Chemistry of Catalonia Curated by ChEMBL | Assay Description Inhibition of aCDase using RBM14C12 as substrate after 1 hr by HPLC-FD analysis | Bioorg Med Chem 20: 3173-9 (2012) Article DOI: 10.1016/j.bmc.2012.03.073 BindingDB Entry DOI: 10.7270/Q2V40W7N | |||||||||||
More data for this Ligand-Target Pair |