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PubMed code 22541041

Compile data set for download or QSAR
Found 84 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nociceptin receptor


(Homo sapiens (Human))
BDBM50420815
PNG
(CHEMBL2088054)
Show SMILES NC(=O)C(CN1CCC2(CC1)OCCc1cc(Cl)sc21)Cc1ccccc1Cl
Show InChI InChI=1S/C21H24Cl2N2O2S/c22-17-4-2-1-3-14(17)11-16(20(24)26)13-25-8-6-21(7-9-25)19-15(5-10-27-21)12-18(23)28-19/h1-4,12,16H,5-11,13H2,(H2,24,26)
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0.0373n/an/an/an/an/an/an/an/a



Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Agonist activity at human cloned NOP receptor expressed in CHO cell membranes after 30 mins by [35S]GTPgammaS binding assay


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50420812
PNG
(CHEMBL2088061)
Show SMILES CN(C1CC1)C(=O)C(CN1CCC2(CC1)OCCc1cc(F)sc21)Cc1ccccc1F
Show InChI InChI=1S/C25H30F2N2O2S/c1-28(20-6-7-20)24(30)19(14-17-4-2-3-5-21(17)26)16-29-11-9-25(10-12-29)23-18(8-13-31-25)15-22(27)32-23/h2-5,15,19-20H,6-14,16H2,1H3
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0.0672n/an/an/an/an/an/an/an/a



Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Agonist activity at human cloned NOP receptor expressed in CHO cell membranes after 30 mins by [35S]GTPgammaS binding assay


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50420804
PNG
(CHEMBL2088055)
Show SMILES CN(C)C(=O)C(CN1CCC2(CC1)OCCc1cc(Cl)sc21)Cc1ccccc1F
Show InChI InChI=1S/C23H28ClFN2O2S/c1-26(2)22(28)18(13-16-5-3-4-6-19(16)25)15-27-10-8-23(9-11-27)21-17(7-12-29-23)14-20(24)30-21/h3-6,14,18H,7-13,15H2,1-2H3
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0.0892n/an/an/an/an/an/an/an/a



Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Agonist activity at human cloned NOP receptor expressed in CHO cell membranes after 30 mins by [35S]GTPgammaS binding assay


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50400866
PNG
(CHEMBL2204348)
Show SMILES CNC(=O)[C@@H](CN1CCC2(CC1)OCCc1cc(F)sc21)Cc1ccccc1Cl |r|
Show InChI InChI=1S/C22H26ClFN2O2S/c1-25-21(27)17(12-15-4-2-3-5-18(15)23)14-26-9-7-22(8-10-26)20-16(6-11-28-22)13-19(24)29-20/h2-5,13,17H,6-12,14H2,1H3,(H,25,27)/t17-/m1/s1
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0.0902n/an/an/an/an/an/an/an/a



Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Agonist activity at human cloned NOP receptor expressed in CHO cell membranes after 30 mins by [35S]GTPgammaS binding assay


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50400874
PNG
(CHEMBL2086410)
Show SMILES NC(=O)[C@H](CN1CCC2(CC1)OCCc1cc(F)sc21)Cc1ccccc1F |r|
Show InChI InChI=1S/C21H24F2N2O2S/c22-17-4-2-1-3-14(17)11-16(20(24)26)13-25-8-6-21(7-9-25)19-15(5-10-27-21)12-18(23)28-19/h1-4,12,16H,5-11,13H2,(H2,24,26)/t16-/m0/s1
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0.106n/an/an/an/an/an/an/an/a



Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Agonist activity at human cloned NOP receptor expressed in CHO cell membranes after 30 mins by [35S]GTPgammaS binding assay


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50420810
PNG
(CHEMBL2088060)
Show SMILES CN(C)C(=O)[C@H](CN1CCC2(CC1)OCCc1cc(F)sc21)Cc1ccccc1F |r|
Show InChI InChI=1S/C23H28F2N2O2S/c1-26(2)22(28)18(13-16-5-3-4-6-19(16)24)15-27-10-8-23(9-11-27)21-17(7-12-29-23)14-20(25)30-21/h3-6,14,18H,7-13,15H2,1-2H3/t18-/m0/s1
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0.114n/an/an/an/an/an/an/an/a



Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Agonist activity at human cloned NOP receptor expressed in CHO cell membranes after 30 mins by [35S]GTPgammaS binding assay


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50420816
PNG
(CHEMBL2088053)
Show SMILES CNC(=O)C(CN1CCC2(CC1)OCCc1cc(Cl)sc21)Cc1ccccc1Cl
Show InChI InChI=1S/C22H26Cl2N2O2S/c1-25-21(27)17(12-15-4-2-3-5-18(15)23)14-26-9-7-22(8-10-26)20-16(6-11-28-22)13-19(24)29-20/h2-5,13,17H,6-12,14H2,1H3,(H,25,27)
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0.124n/an/an/an/an/an/an/an/a



Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Agonist activity at human cloned NOP receptor expressed in CHO cell membranes after 30 mins by [35S]GTPgammaS binding assay


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50420814
PNG
(CHEMBL2088056)
Show SMILES CNC(=O)C(CN1CCC2(CC1)OCCc1cc(Cl)sc21)Cc1ccccc1F
Show InChI InChI=1S/C22H26ClFN2O2S/c1-25-21(27)17(12-15-4-2-3-5-18(15)24)14-26-9-7-22(8-10-26)20-16(6-11-28-22)13-19(23)29-20/h2-5,13,17H,6-12,14H2,1H3,(H,25,27)
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0.127n/an/an/an/an/an/an/an/a



Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Agonist activity at human cloned NOP receptor expressed in CHO cell membranes after 30 mins by [35S]GTPgammaS binding assay


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50420803
PNG
(CHEMBL2088057)
Show SMILES CN(C)C(=O)C(CN1CCC2(CC1)OCCc1cc(F)sc21)Cc1ccccc1Cl
Show InChI InChI=1S/C23H28ClFN2O2S/c1-26(2)22(28)18(13-16-5-3-4-6-19(16)24)15-27-10-8-23(9-11-27)21-17(7-12-29-23)14-20(25)30-21/h3-6,14,18H,7-13,15H2,1-2H3
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0.134n/an/an/an/an/an/an/an/a



Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Agonist activity at human cloned NOP receptor expressed in CHO cell membranes after 30 mins by [35S]GTPgammaS binding assay


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50400873
PNG
(CHEMBL2088029)
Show SMILES CC(C)N(C)C(=O)[C@H](CN1CCC2(CC1)OCCc1cc(F)sc21)Cc1ccccc1F |r|
Show InChI InChI=1S/C25H32F2N2O2S/c1-17(2)28(3)24(30)20(14-18-6-4-5-7-21(18)26)16-29-11-9-25(10-12-29)23-19(8-13-31-25)15-22(27)32-23/h4-7,15,17,20H,8-14,16H2,1-3H3/t20-/m0/s1
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0.137n/an/an/an/an/an/an/an/a



Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Agonist activity at human cloned NOP receptor expressed in CHO cell membranes after 30 mins by [35S]GTPgammaS binding assay


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50420805
PNG
(CHEMBL2088052)
Show SMILES CN(C)C(=O)C(CN1CCC2(CC1)OCCc1cc(Cl)sc21)Cc1ccccc1Cl
Show InChI InChI=1S/C23H28Cl2N2O2S/c1-26(2)22(28)18(13-16-5-3-4-6-19(16)24)15-27-10-8-23(9-11-27)21-17(7-12-29-23)14-20(25)30-21/h3-6,14,18H,7-13,15H2,1-2H3
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0.169n/an/an/an/an/an/an/an/a



Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Agonist activity at human cloned NOP receptor expressed in CHO cell membranes after 30 mins by [35S]GTPgammaS binding assay


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50400872
PNG
(CHEMBL2088033)
Show SMILES CNC(=O)[C@H](CN1CCC2(CC1)OCCc1cc(F)sc21)Cc1ccccc1F |r|
Show InChI InChI=1S/C22H26F2N2O2S/c1-25-21(27)17(12-15-4-2-3-5-18(15)23)14-26-9-7-22(8-10-26)20-16(6-11-28-22)13-19(24)29-20/h2-5,13,17H,6-12,14H2,1H3,(H,25,27)/t17-/m0/s1
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0.174n/an/an/an/an/an/an/an/a



Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Agonist activity at human cloned NOP receptor expressed in CHO cell membranes after 30 mins by [35S]GTPgammaS binding assay


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50420811
PNG
(CHEMBL2088062)
Show SMILES CN(C1CC1)C(=O)C(CN1CCC2(CC1)OCCc1cc(F)sc21)Cc1ccccc1Cl
Show InChI InChI=1S/C25H30ClFN2O2S/c1-28(20-6-7-20)24(30)19(14-17-4-2-3-5-21(17)26)16-29-11-9-25(10-12-29)23-18(8-13-31-25)15-22(27)32-23/h2-5,15,19-20H,6-14,16H2,1H3
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0.194n/an/an/an/an/an/an/an/a



Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Agonist activity at human cloned NOP receptor expressed in CHO cell membranes after 30 mins by [35S]GTPgammaS binding assay


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50400871
PNG
(CHEMBL2088030)
Show SMILES CC(C)NC(=O)[C@H](CN1CCC2(CC1)OCCc1cc(F)sc21)Cc1ccccc1F |r|
Show InChI InChI=1S/C24H30F2N2O2S/c1-16(2)27-23(29)19(13-17-5-3-4-6-20(17)25)15-28-10-8-24(9-11-28)22-18(7-12-30-24)14-21(26)31-22/h3-6,14,16,19H,7-13,15H2,1-2H3,(H,27,29)/t19-/m0/s1
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0.231n/an/an/an/an/an/an/an/a



Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Agonist activity at human cloned NOP receptor expressed in CHO cell membranes after 30 mins by [35S]GTPgammaS binding assay


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50420817
PNG
(CHEMBL2088051)
Show SMILES CN(C)C(=O)C(CN1CCC2(CC1)OCCc1cc(F)sc21)Cn1cccn1
Show InChI InChI=1S/C20H27FN4O2S/c1-23(2)19(26)16(14-25-8-3-7-22-25)13-24-9-5-20(6-10-24)18-15(4-11-27-20)12-17(21)28-18/h3,7-8,12,16H,4-6,9-11,13-14H2,1-2H3
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0.248n/an/an/an/an/an/an/an/a



Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Agonist activity at human cloned NOP receptor expressed in CHO cell membranes after 30 mins by [35S]GTPgammaS binding assay


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50400870
PNG
(CHEMBL559569 | SB-612111)
Show SMILES Cc1cccc2C(O)CC(CN3CCC(CC3)c3c(Cl)cccc3Cl)CCc12
Show InChI InChI=1S/C24H29Cl2NO/c1-16-4-2-5-20-19(16)9-8-17(14-23(20)28)15-27-12-10-18(11-13-27)24-21(25)6-3-7-22(24)26/h2-7,17-18,23,28H,8-15H2,1H3
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0.253n/an/an/an/an/an/an/an/a



Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Agonist activity at human cloned NOP receptor expressed in CHO cell membranes after 30 mins by [35S]GTPgammaS binding assay


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Nociceptin receptor


(Homo sapiens (Human))
BDBM50420801
PNG
(CHEMBL2088035)
Show SMILES CNC(=O)Cn1c2ccccc2n(C2CCN(CC2)[C@@H]2Cc3cccc4cccc2c34)c1=O |r|
Show InChI InChI=1S/C27H28N4O2/c1-28-25(32)17-30-22-10-2-3-11-23(22)31(27(30)33)20-12-14-29(15-13-20)24-16-19-8-4-6-18-7-5-9-21(24)26(18)19/h2-11,20,24H,12-17H2,1H3,(H,28,32)/t24-/m1/s1
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0.336n/an/an/an/an/an/an/an/a



Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Displacement of [3H]Nociceptin from human recombinant NOP receptor expressed in CHO cells by scintillation counter


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50420813
PNG
(CHEMBL2088059)
Show SMILES CN(C)C(=O)C(CN1CCC2(CC1)OCCc1cc(F)sc21)Cc1ccccc1F
Show InChI InChI=1S/C23H28F2N2O2S/c1-26(2)22(28)18(13-16-5-3-4-6-19(16)24)15-27-10-8-23(9-11-27)21-17(7-12-29-23)14-20(25)30-21/h3-6,14,18H,7-13,15H2,1-2H3
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0.396n/an/an/an/an/an/an/an/a



Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Agonist activity at human cloned NOP receptor expressed in CHO cell membranes after 30 mins by [35S]GTPgammaS binding assay


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50083230
PNG
(1-((3R,4R)-1-Cyclooctylmethyl-3-hydroxymethyl-pipe...)
Show SMILES CCn1c2ccccc2n([C@@H]2CCN(CC3CCCCCCC3)C[C@H]2CO)c1=O
Show InChI InChI=1S/C24H37N3O2/c1-2-26-22-12-8-9-13-23(22)27(24(26)29)21-14-15-25(17-20(21)18-28)16-19-10-6-4-3-5-7-11-19/h8-9,12-13,19-21,28H,2-7,10-11,14-18H2,1H3/t20-,21+/m0/s1
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0.403n/an/an/an/an/an/an/an/a



Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Agonist activity at human cloned NOP receptor expressed in CHO cell membranes after 30 mins by [35S]GTPgammaS binding assay


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50420802
PNG
(CHEMBL2088034)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC1)[C@H]1CC[C@@H]2CCCc3cccc1c23 |r|
Show InChI InChI=1S/C26H31N3O/c30-25-26(29(18-27-25)21-9-2-1-3-10-21)14-16-28(17-15-26)23-13-12-20-7-4-6-19-8-5-11-22(23)24(19)20/h1-3,5,8-11,20,23H,4,6-7,12-18H2,(H,27,30)/t20-,23-/m0/s1
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1.10n/an/an/an/an/an/an/an/a



Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Displacement of [3H]Nociceptin from human recombinant NOP receptor expressed in CHO cells by scintillation counter


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50420799
PNG
(CHEMBL2088037)
Show SMILES CN(C)C(=O)C(CN1CCC2(CC1)OCc1ccc(F)cc21)Cc1cscn1
Show InChI InChI=1S/C21H26FN3O2S/c1-24(2)20(26)16(9-18-13-28-14-23-18)11-25-7-5-21(6-8-25)19-10-17(22)4-3-15(19)12-27-21/h3-4,10,13-14,16H,5-9,11-12H2,1-2H3
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1.60n/an/an/an/an/an/an/an/a



Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Agonist activity at human cloned NOP receptor expressed in CHO cell membranes after 30 mins by [35S]GTPgammaS binding assay


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50420808
PNG
(CHEMBL2088041 | CHEMBL2088042)
Show SMILES CN(C)C(=O)C(CN1CCC2(CC1)OCCc1ccsc21)Cc1ccccc1Cl
Show InChI InChI=1S/C23H29ClN2O2S/c1-25(2)22(27)19(15-18-5-3-4-6-20(18)24)16-26-11-9-23(10-12-26)21-17(7-13-28-23)8-14-29-21/h3-6,8,14,19H,7,9-13,15-16H2,1-2H3
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1.80n/an/an/an/an/an/an/an/a



Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Displacement of [3H]Nociceptin from human recombinant NOP receptor expressed in CHO cells by scintillation counter


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50400869
PNG
(CHEMBL2088031)
Show SMILES CC(C)NC(=O)[C@@H](CN1CCC2(CC1)OCCc1cc(F)sc21)Cc1ccccc1F |r|
Show InChI InChI=1S/C24H30F2N2O2S/c1-16(2)27-23(29)19(13-17-5-3-4-6-20(17)25)15-28-10-8-24(9-11-28)22-18(7-12-30-24)14-21(26)31-22/h3-6,14,16,19H,7-13,15H2,1-2H3,(H,27,29)/t19-/m1/s1
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4.5n/an/an/an/an/an/an/an/a



Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Agonist activity at human cloned NOP receptor expressed in CHO cell membranes after 30 mins by [35S]GTPgammaS binding assay


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50420807
PNG
(CHEMBL2088043)
Show SMILES CN(C)C(=O)C(CN1CCC2(CC1)OCCc1ccsc21)Cc1ccccc1F
Show InChI InChI=1S/C23H29FN2O2S/c1-25(2)22(27)19(15-18-5-3-4-6-20(18)24)16-26-11-9-23(10-12-26)21-17(7-13-28-23)8-14-29-21/h3-6,8,14,19H,7,9-13,15-16H2,1-2H3
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5.20n/an/an/an/an/an/an/an/a



Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Agonist activity at human cloned NOP receptor expressed in CHO cell membranes after 30 mins by [35S]GTPgammaS binding assay


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50400868
PNG
(CHEMBL2204349)
Show SMILES CNC(=O)[C@@H](CN1CCC2(CC1)OCCc1cc(F)sc21)Cc1ccccc1F |r|
Show InChI InChI=1S/C22H26F2N2O2S/c1-25-21(27)17(12-15-4-2-3-5-18(15)23)14-26-9-7-22(8-10-26)20-16(6-11-28-22)13-19(24)29-20/h2-5,13,17H,6-12,14H2,1H3,(H,25,27)/t17-/m1/s1
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5.30n/an/an/an/an/an/an/an/a



Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Agonist activity at human cloned NOP receptor expressed in CHO cell membranes after 30 mins by [35S]GTPgammaS binding assay


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50400867
PNG
(CHEMBL2088032)
Show SMILES NC(=O)[C@@H](CN1CCC2(CC1)OCCc1cc(F)sc21)Cc1ccccc1F |r|
Show InChI InChI=1S/C21H24F2N2O2S/c22-17-4-2-1-3-14(17)11-16(20(24)26)13-25-8-6-21(7-9-25)19-15(5-10-27-21)12-18(23)28-19/h1-4,12,16H,5-11,13H2,(H2,24,26)/t16-/m1/s1
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5.60n/an/an/an/an/an/an/an/a



Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Agonist activity at human cloned NOP receptor expressed in CHO cell membranes after 30 mins by [35S]GTPgammaS binding assay


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50420809
PNG
(CHEMBL2088038 | CHEMBL2088039)
Show SMILES CN(C)C(=O)C(CN1CCC2(CC1)OCCc1ccsc21)Cn1cccn1
Show InChI InChI=1S/C20H28N4O2S/c1-22(2)19(25)17(15-24-9-3-8-21-24)14-23-10-6-20(7-11-23)18-16(4-12-26-20)5-13-27-18/h3,5,8-9,13,17H,4,6-7,10-12,14-15H2,1-2H3
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7.40n/an/an/an/an/an/an/an/a



Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Agonist activity at human cloned NOP receptor expressed in CHO cell membranes after 30 mins by [35S]GTPgammaS binding assay


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50420825
PNG
(CHEMBL2088040)
Show SMILES CN(C)C(=O)C(CN1CCC2(CC1)OCCc1ccsc21)Cc1ccccc1
Show InChI InChI=1S/C23H30N2O2S/c1-24(2)22(26)20(16-18-6-4-3-5-7-18)17-25-12-10-23(11-13-25)21-19(8-14-27-23)9-15-28-21/h3-7,9,15,20H,8,10-14,16-17H2,1-2H3
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9.40n/an/an/an/an/an/an/an/a



Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Agonist activity at human cloned NOP receptor expressed in CHO cell membranes after 30 mins by [35S]GTPgammaS binding assay


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50420806
PNG
(CHEMBL2088044)
Show SMILES CN(C)C(=O)C(CN1CCC2(CC1)OCCc1ccsc21)Cc1c(F)cccc1F
Show InChI InChI=1S/C23H28F2N2O2S/c1-26(2)22(28)17(14-18-19(24)4-3-5-20(18)25)15-27-10-8-23(9-11-27)21-16(6-12-29-23)7-13-30-21/h3-5,7,13,17H,6,8-12,14-15H2,1-2H3
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>10n/an/an/an/an/an/an/an/a



Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Agonist activity at human cloned NOP receptor expressed in CHO cell membranes after 30 mins by [35S]GTPgammaS binding assay


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50420822
PNG
(CHEMBL2088046)
Show SMILES COc1ccccc1CC(CN1CCC2(CC1)OCCc1ccsc21)C(=O)N(C)C
Show InChI InChI=1S/C24H32N2O3S/c1-25(2)23(27)20(16-19-6-4-5-7-21(19)28-3)17-26-12-10-24(11-13-26)22-18(8-14-29-24)9-15-30-22/h4-7,9,15,20H,8,10-14,16-17H2,1-3H3
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>10n/an/an/an/an/an/an/an/a



Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Agonist activity at human cloned NOP receptor expressed in CHO cell membranes after 30 mins by [35S]GTPgammaS binding assay


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50420823
PNG
(CHEMBL2088045)
Show SMILES CN(C)C(=O)C(CN1CCC2(CC1)OCCc1ccsc21)Cc1ccccn1
Show InChI InChI=1S/C22H29N3O2S/c1-24(2)21(26)18(15-19-5-3-4-10-23-19)16-25-11-8-22(9-12-25)20-17(6-13-27-22)7-14-28-20/h3-5,7,10,14,18H,6,8-9,11-13,15-16H2,1-2H3
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>10n/an/an/an/an/an/an/an/a



Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Agonist activity at human cloned NOP receptor expressed in CHO cell membranes after 30 mins by [35S]GTPgammaS binding assay


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50420821
PNG
(CHEMBL2088047)
Show SMILES FCC(CN1CCC2(CC1)OCCc1ccsc21)Cc1ccccc1Cl
Show InChI InChI=1S/C21H25ClFNOS/c22-19-4-2-1-3-18(19)13-16(14-23)15-24-9-7-21(8-10-24)20-17(5-11-25-21)6-12-26-20/h1-4,6,12,16H,5,7-11,13-15H2
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>10n/an/an/an/an/an/an/an/a



Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Agonist activity at human cloned NOP receptor expressed in CHO cell membranes after 30 mins by [35S]GTPgammaS binding assay


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50420800
PNG
(CHEMBL2088036)
Show SMILES COC(=O)CN1CN(c2ccccc2)C2(CCN(Cc3cccc4ccccc34)CC2)C1=O
Show InChI InChI=1S/C27H29N3O3/c1-33-25(31)19-29-20-30(23-11-3-2-4-12-23)27(26(29)32)14-16-28(17-15-27)18-22-10-7-9-21-8-5-6-13-24(21)22/h2-13H,14-20H2,1H3
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13n/an/an/an/an/an/an/an/a



Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Displacement of [3H]Nociceptin from human recombinant NOP receptor expressed in CHO cells by scintillation counter


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50420820
PNG
(CHEMBL2088048)
Show SMILES COCC(CN1CCC2(CC1)OCCc1ccsc21)Cc1ccccc1Cl
Show InChI InChI=1S/C22H28ClNO2S/c1-25-16-17(14-19-4-2-3-5-20(19)23)15-24-10-8-22(9-11-24)21-18(6-12-26-22)7-13-27-21/h2-5,7,13,17H,6,8-12,14-16H2,1H3
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>40n/an/an/an/an/an/an/an/a



Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Agonist activity at human cloned NOP receptor expressed in CHO cell membranes after 30 mins by [35S]GTPgammaS binding assay


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50420818
PNG
(CHEMBL2088050)
Show SMILES ClCC(CN1CCC2(CC1)OCCc1ccsc21)Cc1ccccc1Cl
Show InChI InChI=1S/C21H25Cl2NOS/c22-14-16(13-18-3-1-2-4-19(18)23)15-24-9-7-21(8-10-24)20-17(5-11-25-21)6-12-26-20/h1-4,6,12,16H,5,7-11,13-15H2
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>40n/an/an/an/an/an/an/an/a



Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Agonist activity at human cloned NOP receptor expressed in CHO cell membranes after 30 mins by [35S]GTPgammaS binding assay


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50420819
PNG
(CHEMBL2088049)
Show SMILES Clc1ccccc1CC(CN1CCC2(CC1)OCCc1ccsc21)C#N
Show InChI InChI=1S/C21H23ClN2OS/c22-19-4-2-1-3-18(19)13-16(14-23)15-24-9-7-21(8-10-24)20-17(5-11-25-21)6-12-26-20/h1-4,6,12,16H,5,7-11,13,15H2
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>40n/an/an/an/an/an/an/an/a



Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Agonist activity at human cloned NOP receptor expressed in CHO cell membranes after 30 mins by [35S]GTPgammaS binding assay


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50420808
PNG
(CHEMBL2088041 | CHEMBL2088042)
Show SMILES CN(C)C(=O)C(CN1CCC2(CC1)OCCc1ccsc21)Cc1ccccc1Cl
Show InChI InChI=1S/C23H29ClN2O2S/c1-25(2)22(27)19(15-18-5-3-4-6-20(18)24)16-26-11-9-23(10-12-26)21-17(7-13-28-23)8-14-29-21/h3-6,8,14,19H,7,9-13,15-16H2,1-2H3
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219n/an/an/an/an/an/an/an/a



Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Agonist activity at human cloned NOP receptor expressed in CHO cell membranes after 30 mins by [35S]GTPgammaS binding assay


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50420808
PNG
(CHEMBL2088041 | CHEMBL2088042)
Show SMILES CN(C)C(=O)C(CN1CCC2(CC1)OCCc1ccsc21)Cc1ccccc1Cl
Show InChI InChI=1S/C23H29ClN2O2S/c1-25(2)22(27)19(15-18-5-3-4-6-20(18)24)16-26-11-9-23(10-12-26)21-17(7-13-28-23)8-14-29-21/h3-6,8,14,19H,7,9-13,15-16H2,1-2H3
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219n/an/an/an/an/an/an/an/a



Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Displacement of [3H]Nociceptin from human recombinant NOP receptor expressed in CHO cells by scintillation counter


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50420808
PNG
(CHEMBL2088041 | CHEMBL2088042)
Show SMILES CN(C)C(=O)C(CN1CCC2(CC1)OCCc1ccsc21)Cc1ccccc1Cl
Show InChI InChI=1S/C23H29ClN2O2S/c1-25(2)22(27)19(15-18-5-3-4-6-20(18)24)16-26-11-9-23(10-12-26)21-17(7-13-28-23)8-14-29-21/h3-6,8,14,19H,7,9-13,15-16H2,1-2H3
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>400n/an/an/an/an/an/an/an/a



Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human cloned mu type opioid receptor expressed in CHO cell membranes by scintillation counter


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50420800
PNG
(CHEMBL2088036)
Show SMILES COC(=O)CN1CN(c2ccccc2)C2(CCN(Cc3cccc4ccccc34)CC2)C1=O
Show InChI InChI=1S/C27H29N3O3/c1-33-25(31)19-29-20-30(23-11-3-2-4-12-23)27(26(29)32)14-16-28(17-15-27)18-22-10-7-9-21-8-5-6-13-24(21)22/h2-13H,14-20H2,1H3
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>400n/an/an/an/an/an/an/an/a



Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human cloned kappa type opioid receptor expressed in CHO cell membranes by scintillation counter


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50420809
PNG
(CHEMBL2088038 | CHEMBL2088039)
Show SMILES CN(C)C(=O)C(CN1CCC2(CC1)OCCc1ccsc21)Cn1cccn1
Show InChI InChI=1S/C20H28N4O2S/c1-22(2)19(25)17(15-24-9-3-8-21-24)14-23-10-6-20(7-11-23)18-16(4-12-26-20)5-13-27-18/h3,5,8-9,13,17H,4,6-7,10-12,14-15H2,1-2H3
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Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human cloned mu type opioid receptor expressed in CHO cell membranes by scintillation counter


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50420808
PNG
(CHEMBL2088041 | CHEMBL2088042)
Show SMILES CN(C)C(=O)C(CN1CCC2(CC1)OCCc1ccsc21)Cc1ccccc1Cl
Show InChI InChI=1S/C23H29ClN2O2S/c1-25(2)22(27)19(15-18-5-3-4-6-20(18)24)16-26-11-9-23(10-12-26)21-17(7-13-28-23)8-14-29-21/h3-6,8,14,19H,7,9-13,15-16H2,1-2H3
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Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human cloned kappa type opioid receptor expressed in CHO cell membranes by scintillation counter


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50400870
PNG
(CHEMBL559569 | SB-612111)
Show SMILES Cc1cccc2C(O)CC(CN3CCC(CC3)c3c(Cl)cccc3Cl)CCc12
Show InChI InChI=1S/C24H29Cl2NO/c1-16-4-2-5-20-19(16)9-8-17(14-23(20)28)15-27-12-10-18(11-13-27)24-21(25)6-3-7-22(24)26/h2-7,17-18,23,28H,8-15H2,1H3
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Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human cloned kappa type opioid receptor expressed in CHO cell membranes by scintillation counter


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50420801
PNG
(CHEMBL2088035)
Show SMILES CNC(=O)Cn1c2ccccc2n(C2CCN(CC2)[C@@H]2Cc3cccc4cccc2c34)c1=O |r|
Show InChI InChI=1S/C27H28N4O2/c1-28-25(32)17-30-22-10-2-3-11-23(22)31(27(30)33)20-12-14-29(15-13-20)24-16-19-8-4-6-18-7-5-9-21(24)26(18)19/h2-11,20,24H,12-17H2,1H3,(H,28,32)/t24-/m1/s1
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Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human cloned delta type opioid receptor expressed in CHO cell membranes by scintillation counter


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50400870
PNG
(CHEMBL559569 | SB-612111)
Show SMILES Cc1cccc2C(O)CC(CN3CCC(CC3)c3c(Cl)cccc3Cl)CCc12
Show InChI InChI=1S/C24H29Cl2NO/c1-16-4-2-5-20-19(16)9-8-17(14-23(20)28)15-27-12-10-18(11-13-27)24-21(25)6-3-7-22(24)26/h2-7,17-18,23,28H,8-15H2,1H3
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Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human cloned delta type opioid receptor expressed in CHO cell membranes by scintillation counter


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50420799
PNG
(CHEMBL2088037)
Show SMILES CN(C)C(=O)C(CN1CCC2(CC1)OCc1ccc(F)cc21)Cc1cscn1
Show InChI InChI=1S/C21H26FN3O2S/c1-24(2)20(26)16(9-18-13-28-14-23-18)11-25-7-5-21(6-8-25)19-10-17(22)4-3-15(19)12-27-21/h3-4,10,13-14,16H,5-9,11-12H2,1-2H3
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Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human cloned delta type opioid receptor expressed in CHO cell membranes by scintillation counter


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50420809
PNG
(CHEMBL2088038 | CHEMBL2088039)
Show SMILES CN(C)C(=O)C(CN1CCC2(CC1)OCCc1ccsc21)Cn1cccn1
Show InChI InChI=1S/C20H28N4O2S/c1-22(2)19(25)17(15-24-9-3-8-21-24)14-23-10-6-20(7-11-23)18-16(4-12-26-20)5-13-27-18/h3,5,8-9,13,17H,4,6-7,10-12,14-15H2,1-2H3
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Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human cloned delta type opioid receptor expressed in CHO cell membranes by scintillation counter


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50420801
PNG
(CHEMBL2088035)
Show SMILES CNC(=O)Cn1c2ccccc2n(C2CCN(CC2)[C@@H]2Cc3cccc4cccc2c34)c1=O |r|
Show InChI InChI=1S/C27H28N4O2/c1-28-25(32)17-30-22-10-2-3-11-23(22)31(27(30)33)20-12-14-29(15-13-20)24-16-19-8-4-6-18-7-5-9-21(24)26(18)19/h2-11,20,24H,12-17H2,1H3,(H,28,32)/t24-/m1/s1
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Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human cloned mu type opioid receptor expressed in CHO cell membranes by scintillation counter


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50420804
PNG
(CHEMBL2088055)
Show SMILES CN(C)C(=O)C(CN1CCC2(CC1)OCCc1cc(Cl)sc21)Cc1ccccc1F
Show InChI InChI=1S/C23H28ClFN2O2S/c1-26(2)22(28)18(13-16-5-3-4-6-19(16)25)15-27-10-8-23(9-11-27)21-17(7-12-29-23)14-20(24)30-21/h3-6,14,18H,7-13,15H2,1-2H3
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Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human cloned kappa type opioid receptor expressed in CHO cell membranes by scintillation counter


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50420805
PNG
(CHEMBL2088052)
Show SMILES CN(C)C(=O)C(CN1CCC2(CC1)OCCc1cc(Cl)sc21)Cc1ccccc1Cl
Show InChI InChI=1S/C23H28Cl2N2O2S/c1-26(2)22(28)18(13-16-5-3-4-6-19(16)24)15-27-10-8-23(9-11-27)21-17(7-12-29-23)14-20(25)30-21/h3-6,14,18H,7-13,15H2,1-2H3
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Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human cloned delta type opioid receptor expressed in CHO cell membranes by scintillation counter


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50420806
PNG
(CHEMBL2088044)
Show SMILES CN(C)C(=O)C(CN1CCC2(CC1)OCCc1ccsc21)Cc1c(F)cccc1F
Show InChI InChI=1S/C23H28F2N2O2S/c1-26(2)22(28)17(14-18-19(24)4-3-5-20(18)25)15-27-10-8-23(9-11-27)21-16(6-12-29-23)7-13-30-21/h3-5,7,13,17H,6,8-12,14-15H2,1-2H3
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Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human cloned delta type opioid receptor expressed in CHO cell membranes by scintillation counter


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50420807
PNG
(CHEMBL2088043)
Show SMILES CN(C)C(=O)C(CN1CCC2(CC1)OCCc1ccsc21)Cc1ccccc1F
Show InChI InChI=1S/C23H29FN2O2S/c1-25(2)22(27)19(15-18-5-3-4-6-20(18)24)16-26-11-9-23(10-12-26)21-17(7-13-28-23)8-14-29-21/h3-6,8,14,19H,7,9-13,15-16H2,1-2H3
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Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human cloned mu type opioid receptor expressed in CHO cell membranes by scintillation counter


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50420799
PNG
(CHEMBL2088037)
Show SMILES CN(C)C(=O)C(CN1CCC2(CC1)OCc1ccc(F)cc21)Cc1cscn1
Show InChI InChI=1S/C21H26FN3O2S/c1-24(2)20(26)16(9-18-13-28-14-23-18)11-25-7-5-21(6-8-25)19-10-17(22)4-3-15(19)12-27-21/h3-4,10,13-14,16H,5-9,11-12H2,1-2H3
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Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human cloned kappa type opioid receptor expressed in CHO cell membranes by scintillation counter


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50420804
PNG
(CHEMBL2088055)
Show SMILES CN(C)C(=O)C(CN1CCC2(CC1)OCCc1cc(Cl)sc21)Cc1ccccc1F
Show InChI InChI=1S/C23H28ClFN2O2S/c1-26(2)22(28)18(13-16-5-3-4-6-19(16)25)15-27-10-8-23(9-11-27)21-17(7-12-29-23)14-20(24)30-21/h3-6,14,18H,7-13,15H2,1-2H3
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Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human cloned delta type opioid receptor expressed in CHO cell membranes by scintillation counter


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50420802
PNG
(CHEMBL2088034)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC1)[C@H]1CC[C@@H]2CCCc3cccc1c23 |r|
Show InChI InChI=1S/C26H31N3O/c30-25-26(29(18-27-25)21-9-2-1-3-10-21)14-16-28(17-15-26)23-13-12-20-7-4-6-19-8-5-11-22(23)24(19)20/h1-3,5,8-11,20,23H,4,6-7,12-18H2,(H,27,30)/t20-,23-/m0/s1
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Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human cloned delta type opioid receptor expressed in CHO cell membranes by scintillation counter


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50420803
PNG
(CHEMBL2088057)
Show SMILES CN(C)C(=O)C(CN1CCC2(CC1)OCCc1cc(F)sc21)Cc1ccccc1Cl
Show InChI InChI=1S/C23H28ClFN2O2S/c1-26(2)22(28)18(13-16-5-3-4-6-19(16)24)15-27-10-8-23(9-11-27)21-17(7-12-29-23)14-20(25)30-21/h3-6,14,18H,7-13,15H2,1-2H3
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Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human cloned delta type opioid receptor expressed in CHO cell membranes by scintillation counter


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50083230
PNG
(1-((3R,4R)-1-Cyclooctylmethyl-3-hydroxymethyl-pipe...)
Show SMILES CCn1c2ccccc2n([C@@H]2CCN(CC3CCCCCCC3)C[C@H]2CO)c1=O
Show InChI InChI=1S/C24H37N3O2/c1-2-26-22-12-8-9-13-23(22)27(24(26)29)21-14-15-25(17-20(21)18-28)16-19-10-6-4-3-5-7-11-19/h8-9,12-13,19-21,28H,2-7,10-11,14-18H2,1H3/t20-,21+/m0/s1
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Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human cloned delta type opioid receptor expressed in CHO cell membranes by scintillation counter


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50420810
PNG
(CHEMBL2088060)
Show SMILES CN(C)C(=O)[C@H](CN1CCC2(CC1)OCCc1cc(F)sc21)Cc1ccccc1F |r|
Show InChI InChI=1S/C23H28F2N2O2S/c1-26(2)22(28)18(13-16-5-3-4-6-19(16)24)15-27-10-8-23(9-11-27)21-17(7-12-29-23)14-20(25)30-21/h3-6,14,18H,7-13,15H2,1-2H3/t18-/m0/s1
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Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human cloned kappa type opioid receptor expressed in CHO cell membranes by scintillation counter


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50420805
PNG
(CHEMBL2088052)
Show SMILES CN(C)C(=O)C(CN1CCC2(CC1)OCCc1cc(Cl)sc21)Cc1ccccc1Cl
Show InChI InChI=1S/C23H28Cl2N2O2S/c1-26(2)22(28)18(13-16-5-3-4-6-19(16)24)15-27-10-8-23(9-11-27)21-17(7-12-29-23)14-20(25)30-21/h3-6,14,18H,7-13,15H2,1-2H3
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Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human cloned kappa type opioid receptor expressed in CHO cell membranes by scintillation counter


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50420807
PNG
(CHEMBL2088043)
Show SMILES CN(C)C(=O)C(CN1CCC2(CC1)OCCc1ccsc21)Cc1ccccc1F
Show InChI InChI=1S/C23H29FN2O2S/c1-25(2)22(27)19(15-18-5-3-4-6-20(18)24)16-26-11-9-23(10-12-26)21-17(7-13-28-23)8-14-29-21/h3-6,8,14,19H,7,9-13,15-16H2,1-2H3
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Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human cloned kappa type opioid receptor expressed in CHO cell membranes by scintillation counter


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50420802
PNG
(CHEMBL2088034)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC1)[C@H]1CC[C@@H]2CCCc3cccc1c23 |r|
Show InChI InChI=1S/C26H31N3O/c30-25-26(29(18-27-25)21-9-2-1-3-10-21)14-16-28(17-15-26)23-13-12-20-7-4-6-19-8-5-11-22(23)24(19)20/h1-3,5,8-11,20,23H,4,6-7,12-18H2,(H,27,30)/t20-,23-/m0/s1
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Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human cloned kappa type opioid receptor expressed in CHO cell membranes by scintillation counter


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50420808
PNG
(CHEMBL2088041 | CHEMBL2088042)
Show SMILES CN(C)C(=O)C(CN1CCC2(CC1)OCCc1ccsc21)Cc1ccccc1Cl
Show InChI InChI=1S/C23H29ClN2O2S/c1-25(2)22(27)19(15-18-5-3-4-6-20(18)24)16-26-11-9-23(10-12-26)21-17(7-13-28-23)8-14-29-21/h3-6,8,14,19H,7,9-13,15-16H2,1-2H3
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Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human cloned delta type opioid receptor expressed in CHO cell membranes by scintillation counter


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50420800
PNG
(CHEMBL2088036)
Show SMILES COC(=O)CN1CN(c2ccccc2)C2(CCN(Cc3cccc4ccccc34)CC2)C1=O
Show InChI InChI=1S/C27H29N3O3/c1-33-25(31)19-29-20-30(23-11-3-2-4-12-23)27(26(29)32)14-16-28(17-15-27)18-22-10-7-9-21-8-5-6-13-24(21)22/h2-13H,14-20H2,1H3
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Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human cloned delta type opioid receptor expressed in CHO cell membranes by scintillation counter


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50420804
PNG
(CHEMBL2088055)
Show SMILES CN(C)C(=O)C(CN1CCC2(CC1)OCCc1cc(Cl)sc21)Cc1ccccc1F
Show InChI InChI=1S/C23H28ClFN2O2S/c1-26(2)22(28)18(13-16-5-3-4-6-19(16)25)15-27-10-8-23(9-11-27)21-17(7-12-29-23)14-20(24)30-21/h3-6,14,18H,7-13,15H2,1-2H3
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Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human cloned mu type opioid receptor expressed in CHO cell membranes by scintillation counter


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50083230
PNG
(1-((3R,4R)-1-Cyclooctylmethyl-3-hydroxymethyl-pipe...)
Show SMILES CCn1c2ccccc2n([C@@H]2CCN(CC3CCCCCCC3)C[C@H]2CO)c1=O
Show InChI InChI=1S/C24H37N3O2/c1-2-26-22-12-8-9-13-23(22)27(24(26)29)21-14-15-25(17-20(21)18-28)16-19-10-6-4-3-5-7-11-19/h8-9,12-13,19-21,28H,2-7,10-11,14-18H2,1H3/t20-,21+/m0/s1
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Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human cloned mu type opioid receptor expressed in CHO cell membranes by scintillation counter


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50420802
PNG
(CHEMBL2088034)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC1)[C@H]1CC[C@@H]2CCCc3cccc1c23 |r|
Show InChI InChI=1S/C26H31N3O/c30-25-26(29(18-27-25)21-9-2-1-3-10-21)14-16-28(17-15-26)23-13-12-20-7-4-6-19-8-5-11-22(23)24(19)20/h1-3,5,8-11,20,23H,4,6-7,12-18H2,(H,27,30)/t20-,23-/m0/s1
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Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human cloned mu type opioid receptor expressed in CHO cell membranes by scintillation counter


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50420807
PNG
(CHEMBL2088043)
Show SMILES CN(C)C(=O)C(CN1CCC2(CC1)OCCc1ccsc21)Cc1ccccc1F
Show InChI InChI=1S/C23H29FN2O2S/c1-25(2)22(27)19(15-18-5-3-4-6-20(18)24)16-26-11-9-23(10-12-26)21-17(7-13-28-23)8-14-29-21/h3-6,8,14,19H,7,9-13,15-16H2,1-2H3
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Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human cloned delta type opioid receptor expressed in CHO cell membranes by scintillation counter


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50420810
PNG
(CHEMBL2088060)
Show SMILES CN(C)C(=O)[C@H](CN1CCC2(CC1)OCCc1cc(F)sc21)Cc1ccccc1F |r|
Show InChI InChI=1S/C23H28F2N2O2S/c1-26(2)22(28)18(13-16-5-3-4-6-19(16)24)15-27-10-8-23(9-11-27)21-17(7-12-29-23)14-20(25)30-21/h3-6,14,18H,7-13,15H2,1-2H3/t18-/m0/s1
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Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human cloned delta type opioid receptor expressed in CHO cell membranes by scintillation counter


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50420805
PNG
(CHEMBL2088052)
Show SMILES CN(C)C(=O)C(CN1CCC2(CC1)OCCc1cc(Cl)sc21)Cc1ccccc1Cl
Show InChI InChI=1S/C23H28Cl2N2O2S/c1-26(2)22(28)18(13-16-5-3-4-6-19(16)24)15-27-10-8-23(9-11-27)21-17(7-12-29-23)14-20(25)30-21/h3-6,14,18H,7-13,15H2,1-2H3
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Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human cloned mu type opioid receptor expressed in CHO cell membranes by scintillation counter


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50420806
PNG
(CHEMBL2088044)
Show SMILES CN(C)C(=O)C(CN1CCC2(CC1)OCCc1ccsc21)Cc1c(F)cccc1F
Show InChI InChI=1S/C23H28F2N2O2S/c1-26(2)22(28)17(14-18-19(24)4-3-5-20(18)25)15-27-10-8-23(9-11-27)21-16(6-12-29-23)7-13-30-21/h3-5,7,13,17H,6,8-12,14-15H2,1-2H3
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Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human cloned mu type opioid receptor expressed in CHO cell membranes by scintillation counter


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50400870
PNG
(CHEMBL559569 | SB-612111)
Show SMILES Cc1cccc2C(O)CC(CN3CCC(CC3)c3c(Cl)cccc3Cl)CCc12
Show InChI InChI=1S/C24H29Cl2NO/c1-16-4-2-5-20-19(16)9-8-17(14-23(20)28)15-27-12-10-18(11-13-27)24-21(25)6-3-7-22(24)26/h2-7,17-18,23,28H,8-15H2,1H3
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Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human cloned mu type opioid receptor expressed in CHO cell membranes by scintillation counter


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50420800
PNG
(CHEMBL2088036)
Show SMILES COC(=O)CN1CN(c2ccccc2)C2(CCN(Cc3cccc4ccccc34)CC2)C1=O
Show InChI InChI=1S/C27H29N3O3/c1-33-25(31)19-29-20-30(23-11-3-2-4-12-23)27(26(29)32)14-16-28(17-15-27)18-22-10-7-9-21-8-5-6-13-24(21)22/h2-13H,14-20H2,1H3
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Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human cloned mu type opioid receptor expressed in CHO cell membranes by scintillation counter


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50420806
PNG
(CHEMBL2088044)
Show SMILES CN(C)C(=O)C(CN1CCC2(CC1)OCCc1ccsc21)Cc1c(F)cccc1F
Show InChI InChI=1S/C23H28F2N2O2S/c1-26(2)22(28)17(14-18-19(24)4-3-5-20(18)25)15-27-10-8-23(9-11-27)21-16(6-12-29-23)7-13-30-21/h3-5,7,13,17H,6,8-12,14-15H2,1-2H3
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Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human cloned kappa type opioid receptor expressed in CHO cell membranes by scintillation counter


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50420803
PNG
(CHEMBL2088057)
Show SMILES CN(C)C(=O)C(CN1CCC2(CC1)OCCc1cc(F)sc21)Cc1ccccc1Cl
Show InChI InChI=1S/C23H28ClFN2O2S/c1-26(2)22(28)18(13-16-5-3-4-6-19(16)24)15-27-10-8-23(9-11-27)21-17(7-12-29-23)14-20(25)30-21/h3-6,14,18H,7-13,15H2,1-2H3
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Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human cloned mu type opioid receptor expressed in CHO cell membranes by scintillation counter


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50420799
PNG
(CHEMBL2088037)
Show SMILES CN(C)C(=O)C(CN1CCC2(CC1)OCc1ccc(F)cc21)Cc1cscn1
Show InChI InChI=1S/C21H26FN3O2S/c1-24(2)20(26)16(9-18-13-28-14-23-18)11-25-7-5-21(6-8-25)19-10-17(22)4-3-15(19)12-27-21/h3-4,10,13-14,16H,5-9,11-12H2,1-2H3
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Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human cloned mu type opioid receptor expressed in CHO cell membranes by scintillation counter


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50420803
PNG
(CHEMBL2088057)
Show SMILES CN(C)C(=O)C(CN1CCC2(CC1)OCCc1cc(F)sc21)Cc1ccccc1Cl
Show InChI InChI=1S/C23H28ClFN2O2S/c1-26(2)22(28)18(13-16-5-3-4-6-19(16)24)15-27-10-8-23(9-11-27)21-17(7-12-29-23)14-20(25)30-21/h3-6,14,18H,7-13,15H2,1-2H3
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Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human cloned kappa type opioid receptor expressed in CHO cell membranes by scintillation counter


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50420809
PNG
(CHEMBL2088038 | CHEMBL2088039)
Show SMILES CN(C)C(=O)C(CN1CCC2(CC1)OCCc1ccsc21)Cn1cccn1
Show InChI InChI=1S/C20H28N4O2S/c1-22(2)19(25)17(15-24-9-3-8-21-24)14-23-10-6-20(7-11-23)18-16(4-12-26-20)5-13-27-18/h3,5,8-9,13,17H,4,6-7,10-12,14-15H2,1-2H3
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Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human cloned kappa type opioid receptor expressed in CHO cell membranes by scintillation counter


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50420801
PNG
(CHEMBL2088035)
Show SMILES CNC(=O)Cn1c2ccccc2n(C2CCN(CC2)[C@@H]2Cc3cccc4cccc2c34)c1=O |r|
Show InChI InChI=1S/C27H28N4O2/c1-28-25(32)17-30-22-10-2-3-11-23(22)31(27(30)33)20-12-14-29(15-13-20)24-16-19-8-4-6-18-7-5-9-21(24)26(18)19/h2-11,20,24H,12-17H2,1H3,(H,28,32)/t24-/m1/s1
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Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human cloned kappa type opioid receptor expressed in CHO cell membranes by scintillation counter


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50083230
PNG
(1-((3R,4R)-1-Cyclooctylmethyl-3-hydroxymethyl-pipe...)
Show SMILES CCn1c2ccccc2n([C@@H]2CCN(CC3CCCCCCC3)C[C@H]2CO)c1=O
Show InChI InChI=1S/C24H37N3O2/c1-2-26-22-12-8-9-13-23(22)27(24(26)29)21-14-15-25(17-20(21)18-28)16-19-10-6-4-3-5-7-11-19/h8-9,12-13,19-21,28H,2-7,10-11,14-18H2,1H3/t20-,21+/m0/s1
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Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human cloned kappa type opioid receptor expressed in CHO cell membranes by scintillation counter


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50420810
PNG
(CHEMBL2088060)
Show SMILES CN(C)C(=O)[C@H](CN1CCC2(CC1)OCCc1cc(F)sc21)Cc1ccccc1F |r|
Show InChI InChI=1S/C23H28F2N2O2S/c1-26(2)22(28)18(13-16-5-3-4-6-19(16)24)15-27-10-8-23(9-11-27)21-17(7-12-29-23)14-20(25)30-21/h3-6,14,18H,7-13,15H2,1-2H3/t18-/m0/s1
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Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human cloned mu type opioid receptor expressed in CHO cell membranes by scintillation counter


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50420809
PNG
(CHEMBL2088038 | CHEMBL2088039)
Show SMILES CN(C)C(=O)C(CN1CCC2(CC1)OCCc1ccsc21)Cn1cccn1
Show InChI InChI=1S/C20H28N4O2S/c1-22(2)19(25)17(15-24-9-3-8-21-24)14-23-10-6-20(7-11-23)18-16(4-12-26-20)5-13-27-18/h3,5,8-9,13,17H,4,6-7,10-12,14-15H2,1-2H3
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403n/an/an/an/an/an/an/an/a



Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Displacement of [3H]Nociceptin from human recombinant NOP receptor expressed in CHO cells by scintillation counter


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50420800
PNG
(CHEMBL2088036)
Show SMILES COC(=O)CN1CN(c2ccccc2)C2(CCN(Cc3cccc4ccccc34)CC2)C1=O
Show InChI InChI=1S/C27H29N3O3/c1-33-25(31)19-29-20-30(23-11-3-2-4-12-23)27(26(29)32)14-16-28(17-15-27)18-22-10-7-9-21-8-5-6-13-24(21)22/h2-13H,14-20H2,1H3
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n/an/an/an/a 121n/an/an/an/a



Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Agonist activity at human cloned NOP receptor expressed in CHO cell membranes after 30 mins by [35S]GTPgammaS binding assay


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50420802
PNG
(CHEMBL2088034)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC1)[C@H]1CC[C@@H]2CCCc3cccc1c23 |r|
Show InChI InChI=1S/C26H31N3O/c30-25-26(29(18-27-25)21-9-2-1-3-10-21)14-16-28(17-15-26)23-13-12-20-7-4-6-19-8-5-11-22(23)24(19)20/h1-3,5,8-11,20,23H,4,6-7,12-18H2,(H,27,30)/t20-,23-/m0/s1
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n/an/an/an/a 21n/an/an/an/a



Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Agonist activity at human cloned NOP receptor expressed in CHO cell membranes after 30 mins by [35S]GTPgammaS binding assay


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50420801
PNG
(CHEMBL2088035)
Show SMILES CNC(=O)Cn1c2ccccc2n(C2CCN(CC2)[C@@H]2Cc3cccc4cccc2c34)c1=O |r|
Show InChI InChI=1S/C27H28N4O2/c1-28-25(32)17-30-22-10-2-3-11-23(22)31(27(30)33)20-12-14-29(15-13-20)24-16-19-8-4-6-18-7-5-9-21(24)26(18)19/h2-11,20,24H,12-17H2,1H3,(H,28,32)/t24-/m1/s1
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n/an/an/an/a 1.60n/an/an/an/a



Centro de Investigaci�n Lilly

Curated by ChEMBL


Assay Description
Agonist activity at human cloned NOP receptor expressed in CHO cell membranes after 30 mins by [35S]GTPgammaS binding assay


J Med Chem 55: 4955-67 (2012)


Article DOI: 10.1021/jm201629q
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%