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PubMed code 22546206

Compile data set for download or QSAR
Found 162 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Prostaglandin E2 receptor EP4 subtype


(Mus musculus (Mouse))		BDBM50366138
PNG
(CHEMBL1957437)
Show SMILES O[C@@H](Cc1cccc(c1)-c1ccc2ccccc2c1)\C=C\[C@H]1CCC(=O)N1CCSc1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C30H28N2O4S2/c33-26(17-20-4-3-7-22(16-20)24-9-8-21-5-1-2-6-23(21)18-24)12-10-25-11-13-28(34)32(25)14-15-37-30-31-27(19-38-30)29(35)36/h1-10,12,16,18-19,25-26,33H,11,13-15,17H2,(H,35,36)/b12-10+/t25-,26+/m0/s1
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 0.0120n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP4 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Mus musculus (Mouse))		BDBM50385124
PNG
(CHEMBL2036314)
Show SMILES O[C@@H](Cc1cccc(c1)-c1cc2ccccc2o1)\C=C\[C@H]1CCC(=O)N1CCSCCCC(O)=O |r|
Show InChI InChI=1S/C28H31NO5S/c30-24(12-10-23-11-13-27(31)29(23)14-16-35-15-4-9-28(32)33)18-20-5-3-7-21(17-20)26-19-22-6-1-2-8-25(22)34-26/h1-3,5-8,10,12,17,19,23-24,30H,4,9,11,13-16,18H2,(H,32,33)/b12-10+/t23-,24+/m0/s1
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 0.100n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP4 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Mus musculus (Mouse))		BDBM50385132
PNG
(CHEMBL2036323)
Show SMILES O[C@@H](Cc1cccc(c1)-c1nc2ccccc2o1)\C=C\[C@H]1CCC(=O)N1CCSc1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C27H25N3O5S2/c31-20(15-17-4-3-5-18(14-17)25-28-21-6-1-2-7-23(21)35-25)10-8-19-9-11-24(32)30(19)12-13-36-27-29-22(16-37-27)26(33)34/h1-8,10,14,16,19-20,31H,9,11-13,15H2,(H,33,34)/b10-8+/t19-,20+/m0/s1
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 0.120n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP4 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Mus musculus (Mouse))		BDBM50385131
PNG
(CHEMBL2036322)
Show SMILES O[C@@H](Cc1cccc(c1)-c1cc2ccccc2o1)\C=C\[C@H]1CCC(=O)N1CCSc1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C28H26N2O5S2/c31-22(15-18-4-3-6-19(14-18)25-16-20-5-1-2-7-24(20)35-25)10-8-21-9-11-26(32)30(21)12-13-36-28-29-23(17-37-28)27(33)34/h1-8,10,14,16-17,21-22,31H,9,11-13,15H2,(H,33,34)/b10-8+/t21-,22+/m0/s1
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 0.120n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP4 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Mus musculus (Mouse))		BDBM50385138
PNG
(CHEMBL2037291)
Show SMILES Cc1cc(C)c2oc(nc2c1)-c1cccc(C[C@H](O)\C=C\[C@H]2CCC(=O)N2CCSc2nc(cs2)C(O)=O)c1 |r|
Show InChI InChI=1S/C29H29N3O5S2/c1-17-12-18(2)26-23(13-17)30-27(37-26)20-5-3-4-19(14-20)15-22(33)8-6-21-7-9-25(34)32(21)10-11-38-29-31-24(16-39-29)28(35)36/h3-6,8,12-14,16,21-22,33H,7,9-11,15H2,1-2H3,(H,35,36)/b8-6+/t21-,22+/m0/s1
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 0.150n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP4 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Mus musculus (Mouse))		BDBM50385136
PNG
(CHEMBL2037289)
Show SMILES Cc1ccc2nc(oc2c1)-c1cccc(C[C@H](O)\C=C\[C@H]2CCC(=O)N2CCSc2nc(cs2)C(O)=O)c1 |r|
Show InChI InChI=1S/C28H27N3O5S2/c1-17-5-9-22-24(13-17)36-26(29-22)19-4-2-3-18(14-19)15-21(32)8-6-20-7-10-25(33)31(20)11-12-37-28-30-23(16-38-28)27(34)35/h2-6,8-9,13-14,16,20-21,32H,7,10-12,15H2,1H3,(H,34,35)/b8-6+/t20-,21+/m0/s1
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 0.160n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP4 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Mus musculus (Mouse))		BDBM50385133
PNG
(CHEMBL2036324)
Show SMILES O[C@@H](Cc1cccc(c1)-c1nc2ccccc2s1)\C=C\[C@H]1CCC(=O)N1CCSc1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C27H25N3O4S3/c31-20(15-17-4-3-5-18(14-17)25-28-21-6-1-2-7-23(21)37-25)10-8-19-9-11-24(32)30(19)12-13-35-27-29-22(16-36-27)26(33)34/h1-8,10,14,16,19-20,31H,9,11-13,15H2,(H,33,34)/b10-8+/t19-,20+/m0/s1
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 0.190n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP4 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Mus musculus (Mouse))		BDBM50385139
PNG
(CHEMBL2037292)
Show SMILES O[C@@H](Cc1cccc(c1)-c1nc2cc(Cl)ccc2o1)\C=C\[C@H]1CCC(=O)N1CCSc1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C27H24ClN3O5S2/c28-18-4-8-23-21(14-18)29-25(36-23)17-3-1-2-16(12-17)13-20(32)7-5-19-6-9-24(33)31(19)10-11-37-27-30-22(15-38-27)26(34)35/h1-5,7-8,12,14-15,19-20,32H,6,9-11,13H2,(H,34,35)/b7-5+/t19-,20+/m0/s1
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 0.200n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP4 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Mus musculus (Mouse))		BDBM50385122
PNG
(CHEMBL2036312)
Show SMILES O[C@@H](Cc1cccc(c1)-c1nc2ccccc2o1)\C=C\[C@H]1CCC(=O)N1CCSCCCC(O)=O |r|
Show InChI InChI=1S/C27H30N2O5S/c30-22(12-10-21-11-13-25(31)29(21)14-16-35-15-4-9-26(32)33)18-19-5-3-6-20(17-19)27-28-23-7-1-2-8-24(23)34-27/h1-3,5-8,10,12,17,21-22,30H,4,9,11,13-16,18H2,(H,32,33)/b12-10+/t21-,22+/m0/s1
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 0.200n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP4 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Mus musculus (Mouse))		BDBM50385135
PNG
(CHEMBL2036326)
Show SMILES Cc1ccc2oc(nc2c1)-c1cccc(C[C@H](O)\C=C\[C@H]2CCC(=O)N2CCSc2nc(cs2)C(O)=O)c1 |r|
Show InChI InChI=1S/C28H27N3O5S2/c1-17-5-9-24-22(13-17)29-26(36-24)19-4-2-3-18(14-19)15-21(32)8-6-20-7-10-25(33)31(20)11-12-37-28-30-23(16-38-28)27(34)35/h2-6,8-9,13-14,16,20-21,32H,7,10-12,15H2,1H3,(H,34,35)/b8-6+/t20-,21+/m0/s1
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 0.210n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP4 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Mus musculus (Mouse))		BDBM50385137
PNG
(CHEMBL2037290)
Show SMILES Cc1cccc2oc(nc12)-c1cccc(C[C@H](O)\C=C\[C@H]2CCC(=O)N2CCSc2nc(cs2)C(O)=O)c1 |r|
Show InChI InChI=1S/C28H27N3O5S2/c1-17-4-2-7-23-25(17)30-26(36-23)19-6-3-5-18(14-19)15-21(32)10-8-20-9-11-24(33)31(20)12-13-37-28-29-22(16-38-28)27(34)35/h2-8,10,14,16,20-21,32H,9,11-13,15H2,1H3,(H,34,35)/b10-8+/t20-,21+/m0/s1
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 0.210n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP4 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Mus musculus (Mouse))		BDBM50385134
PNG
(CHEMBL2036325)
Show SMILES O[C@@H](Cc1cccc(c1)-c1nc2cc(Cl)ccc2s1)\C=C\[C@H]1CCC(=O)N1CCSc1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C27H24ClN3O4S3/c28-18-4-8-23-21(14-18)29-25(38-23)17-3-1-2-16(12-17)13-20(32)7-5-19-6-9-24(33)31(19)10-11-36-27-30-22(15-37-27)26(34)35/h1-5,7-8,12,14-15,19-20,32H,6,9-11,13H2,(H,34,35)/b7-5+/t19-,20+/m0/s1
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 0.25n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP4 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Mus musculus (Mouse))		BDBM50385121
PNG
(CHEMBL2036311)
Show SMILES O[C@@H](Cc1cccc(c1)-c1ccc2[nH]ccc2c1)\C=C\[C@H]1CCC(=O)N1CCSCCCC(O)=O |r|
Show InChI InChI=1S/C28H32N2O4S/c31-25(9-7-24-8-11-27(32)30(24)14-16-35-15-2-5-28(33)34)18-20-3-1-4-21(17-20)22-6-10-26-23(19-22)12-13-29-26/h1,3-4,6-7,9-10,12-13,17,19,24-25,29,31H,2,5,8,11,14-16,18H2,(H,33,34)/b9-7+/t24-,25+/m0/s1
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 0.280n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP4 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Mus musculus (Mouse))		BDBM50385141
PNG
(CHEMBL2036321)
Show SMILES Cc1ccc(cc1C)-c1cccc(C[C@H](O)\C=C\[C@H]2CCC(=O)N2CCSc2nc(cs2)C(O)=O)c1 |r|
Show InChI InChI=1S/C28H30N2O4S2/c1-18-6-7-22(14-19(18)2)21-5-3-4-20(15-21)16-24(31)10-8-23-9-11-26(32)30(23)12-13-35-28-29-25(17-36-28)27(33)34/h3-8,10,14-15,17,23-24,31H,9,11-13,16H2,1-2H3,(H,33,34)/b10-8+/t23-,24+/m0/s1
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 0.350n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP4 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Mus musculus (Mouse))		BDBM50385123
PNG
(CHEMBL2036313)
Show SMILES O[C@@H](Cc1cccc(c1)-c1nc2ccccc2s1)\C=C\[C@H]1CCC(=O)N1CCSCCCC(O)=O |r|
Show InChI InChI=1S/C27H30N2O4S2/c30-22(12-10-21-11-13-25(31)29(21)14-16-34-15-4-9-26(32)33)18-19-5-3-6-20(17-19)27-28-23-7-1-2-8-24(23)35-27/h1-3,5-8,10,12,17,21-22,30H,4,9,11,13-16,18H2,(H,32,33)/b12-10+/t21-,22+/m0/s1
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 0.360n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP4 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Mus musculus (Mouse))		BDBM50360626
PNG
(CHEMBL1933722)
Show SMILES Cc1cccc(C[C@H](O)\C=C\[C@H]2CCC(=O)N2CCSc2nc(cs2)C(O)=O)c1 |r|
Show InChI InChI=1S/C21H24N2O4S2/c1-14-3-2-4-15(11-14)12-17(24)7-5-16-6-8-19(25)23(16)9-10-28-21-22-18(13-29-21)20(26)27/h2-5,7,11,13,16-17,24H,6,8-10,12H2,1H3,(H,26,27)/b7-5+/t16-,17+/m0/s1
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 0.410n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP4 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Mus musculus (Mouse))		BDBM50385128
PNG
(CHEMBL2036318)
Show SMILES Cc1ccc(cc1)-c1cccc(C[C@H](O)\C=C\[C@H]2CCC(=O)N2CCSc2nc(cs2)C(O)=O)c1 |r|
Show InChI InChI=1S/C27H28N2O4S2/c1-18-5-7-20(8-6-18)21-4-2-3-19(15-21)16-23(30)11-9-22-10-12-25(31)29(22)13-14-34-27-28-24(17-35-27)26(32)33/h2-9,11,15,17,22-23,30H,10,12-14,16H2,1H3,(H,32,33)/b11-9+/t22-,23+/m0/s1
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 0.430n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP4 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Mus musculus (Mouse))		BDBM50385118
PNG
(CHEMBL2036308)
Show SMILES O[C@@H](Cc1cccc(c1)-c1ccc2ccccc2c1)\C=C\[C@H]1CCC(=O)N1CCSCCCC(O)=O |r|
Show InChI InChI=1S/C30H33NO4S/c32-28(14-12-27-13-15-29(33)31(27)16-18-36-17-4-9-30(34)35)20-22-5-3-8-24(19-22)26-11-10-23-6-1-2-7-25(23)21-26/h1-3,5-8,10-12,14,19,21,27-28,32H,4,9,13,15-18,20H2,(H,34,35)/b14-12+/t27-,28+/m0/s1
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 0.600n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP4 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Mus musculus (Mouse))		BDBM50366137
PNG
(CHEMBL1957436)
Show SMILES O[C@@H](Cc1cccc(c1)-c1ccc(Cl)cc1)\C=C\[C@H]1CCC(=O)N1CCSc1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C26H25ClN2O4S2/c27-20-6-4-18(5-7-20)19-3-1-2-17(14-19)15-22(30)10-8-21-9-11-24(31)29(21)12-13-34-26-28-23(16-35-26)25(32)33/h1-8,10,14,16,21-22,30H,9,11-13,15H2,(H,32,33)/b10-8+/t21-,22+/m0/s1
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 0.810n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP4 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Mus musculus (Mouse))		BDBM50385126
PNG
(CHEMBL2036316)
Show SMILES O[C@@H](Cc1cccc(OCc2ccccn2)c1)\C=C\[C@H]1CCC(=O)N1CCSCCCC(O)=O |r|
Show InChI InChI=1S/C26H32N2O5S/c29-23(17-20-5-3-7-24(18-20)33-19-21-6-1-2-13-27-21)11-9-22-10-12-25(30)28(22)14-16-34-15-4-8-26(31)32/h1-3,5-7,9,11,13,18,22-23,29H,4,8,10,12,14-17,19H2,(H,31,32)/b11-9+/t22-,23+/m0/s1
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 0.890n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP4 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Mus musculus (Mouse))		BDBM50366136
PNG
(CHEMBL1957435)
Show SMILES O[C@@H](Cc1cccc(c1)-c1ccccc1)\C=C\[C@H]1CCC(=O)N1CCSc1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C26H26N2O4S2/c29-22(16-18-5-4-8-20(15-18)19-6-2-1-3-7-19)11-9-21-10-12-24(30)28(21)13-14-33-26-27-23(17-34-26)25(31)32/h1-9,11,15,17,21-22,29H,10,12-14,16H2,(H,31,32)/b11-9+/t21-,22+/m0/s1
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 0.940n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP4 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Mus musculus (Mouse))		BDBM50385140
PNG
(CHEMBL2036307)
Show SMILES O[C@@H](Cc1cccc(c1)-c1ccccc1)\C=C\[C@H]1CCC(=O)N1CCSCCCC(O)=O |r|
Show InChI InChI=1S/C26H31NO4S/c28-24(19-20-6-4-9-22(18-20)21-7-2-1-3-8-21)13-11-23-12-14-25(29)27(23)15-17-32-16-5-10-26(30)31/h1-4,6-9,11,13,18,23-24,28H,5,10,12,14-17,19H2,(H,30,31)/b13-11+/t23-,24+/m0/s1
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 1.10n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP4 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Mus musculus (Mouse))		BDBM50385141
PNG
(CHEMBL2036321)
Show SMILES Cc1ccc(cc1C)-c1cccc(C[C@H](O)\C=C\[C@H]2CCC(=O)N2CCSc2nc(cs2)C(O)=O)c1 |r|
Show InChI InChI=1S/C28H30N2O4S2/c1-18-6-7-22(14-19(18)2)21-5-3-4-20(15-21)16-24(31)10-8-23-9-11-26(32)30(23)12-13-35-28-29-25(17-36-28)27(33)34/h3-8,10,14-15,17,23-24,31H,9,11-13,16H2,1-2H3,(H,33,34)/b10-8+/t23-,24+/m0/s1
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 1.5n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Mus musculus (Mouse))		BDBM50366137
PNG
(CHEMBL1957436)
Show SMILES O[C@@H](Cc1cccc(c1)-c1ccc(Cl)cc1)\C=C\[C@H]1CCC(=O)N1CCSc1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C26H25ClN2O4S2/c27-20-6-4-18(5-7-20)19-3-1-2-17(14-19)15-22(30)10-8-21-9-11-24(31)29(21)12-13-34-26-28-23(16-35-26)25(32)33/h1-8,10,14,16,21-22,30H,9,11-13,15H2,(H,32,33)/b10-8+/t21-,22+/m0/s1
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 1.70n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Mus musculus (Mouse))		BDBM50385129
PNG
(CHEMBL2036319)
Show SMILES COc1ccc(cc1)-c1cccc(C[C@H](O)\C=C\[C@H]2CCC(=O)N2CCSc2nc(cs2)C(O)=O)c1 |r|
Show InChI InChI=1S/C27H28N2O5S2/c1-34-23-10-5-19(6-11-23)20-4-2-3-18(15-20)16-22(30)9-7-21-8-12-25(31)29(21)13-14-35-27-28-24(17-36-27)26(32)33/h2-7,9-11,15,17,21-22,30H,8,12-14,16H2,1H3,(H,32,33)/b9-7+/t21-,22+/m0/s1
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 1.70n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP4 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Mus musculus (Mouse))		BDBM50360621
PNG
(CHEMBL1933717)
Show SMILES Cc1cccc(C[C@H](O)\C=C\[C@H]2CCC(=O)N2CCSCCCC(O)=O)c1 |r|
Show InChI InChI=1S/C21H29NO4S/c1-16-4-2-5-17(14-16)15-19(23)9-7-18-8-10-20(24)22(18)11-13-27-12-3-6-21(25)26/h2,4-5,7,9,14,18-19,23H,3,6,8,10-13,15H2,1H3,(H,25,26)/b9-7+/t18-,19+/m0/s1
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 1.80n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP4 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Mus musculus (Mouse))		BDBM50385128
PNG
(CHEMBL2036318)
Show SMILES Cc1ccc(cc1)-c1cccc(C[C@H](O)\C=C\[C@H]2CCC(=O)N2CCSc2nc(cs2)C(O)=O)c1 |r|
Show InChI InChI=1S/C27H28N2O4S2/c1-18-5-7-20(8-6-18)21-4-2-3-19(15-21)16-23(30)11-9-22-10-12-25(31)29(22)13-14-34-27-28-24(17-35-27)26(32)33/h2-9,11,15,17,22-23,30H,10,12-14,16H2,1H3,(H,32,33)/b11-9+/t22-,23+/m0/s1
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 2n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Mus musculus (Mouse))		BDBM50385131
PNG
(CHEMBL2036322)
Show SMILES O[C@@H](Cc1cccc(c1)-c1cc2ccccc2o1)\C=C\[C@H]1CCC(=O)N1CCSc1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C28H26N2O5S2/c31-22(15-18-4-3-6-19(14-18)25-16-20-5-1-2-7-24(20)35-25)10-8-21-9-11-26(32)30(21)12-13-36-28-29-23(17-37-28)27(33)34/h1-8,10,14,16-17,21-22,31H,9,11-13,15H2,(H,33,34)/b10-8+/t21-,22+/m0/s1
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 2.10n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Mus musculus (Mouse))		BDBM50366136
PNG
(CHEMBL1957435)
Show SMILES O[C@@H](Cc1cccc(c1)-c1ccccc1)\C=C\[C@H]1CCC(=O)N1CCSc1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C26H26N2O4S2/c29-22(16-18-5-4-8-20(15-18)19-6-2-1-3-7-19)11-9-21-10-12-24(30)28(21)13-14-33-26-27-23(17-34-26)25(31)32/h1-9,11,15,17,21-22,29H,10,12-14,16H2,(H,31,32)/b11-9+/t21-,22+/m0/s1
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 3n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Mus musculus (Mouse))		BDBM50385130
PNG
(CHEMBL2036320)
Show SMILES Cc1ccc(c(C)c1)-c1cccc(C[C@H](O)\C=C\[C@H]2CCC(=O)N2CCSc2nc(cs2)C(O)=O)c1 |r|
Show InChI InChI=1S/C28H30N2O4S2/c1-18-6-10-24(19(2)14-18)21-5-3-4-20(15-21)16-23(31)9-7-22-8-11-26(32)30(22)12-13-35-28-29-25(17-36-28)27(33)34/h3-7,9-10,14-15,17,22-23,31H,8,11-13,16H2,1-2H3,(H,33,34)/b9-7+/t22-,23+/m0/s1
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 3.5n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP4 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Mus musculus (Mouse))		BDBM50385120
PNG
(CHEMBL2036310)
Show SMILES O[C@@H](Cc1cccc(c1)N1Cc2ccccc2C1)\C=C\[C@H]1CCC(=O)N1CCSCCCC(O)=O |r|
Show InChI InChI=1S/C28H34N2O4S/c31-26(12-10-24-11-13-27(32)30(24)14-16-35-15-4-9-28(33)34)18-21-5-3-8-25(17-21)29-19-22-6-1-2-7-23(22)20-29/h1-3,5-8,10,12,17,24,26,31H,4,9,11,13-16,18-20H2,(H,33,34)/b12-10+/t24-,26+/m0/s1
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 4.40n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP4 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Mus musculus (Mouse))		BDBM50385125
PNG
(CHEMBL2036315)
Show SMILES O[C@@H](Cc1cccc(OCc2cccnc2)c1)\C=C\[C@H]1CCC(=O)N1CCSCCCC(O)=O |r|
Show InChI InChI=1S/C26H32N2O5S/c29-23(16-20-4-1-6-24(17-20)33-19-21-5-2-12-27-18-21)10-8-22-9-11-25(30)28(22)13-15-34-14-3-7-26(31)32/h1-2,4-6,8,10,12,17-18,22-23,29H,3,7,9,11,13-16,19H2,(H,31,32)/b10-8+/t22-,23+/m0/s1
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 4.70n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP4 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Mus musculus (Mouse))		BDBM50385119
PNG
(CHEMBL2036309)
Show SMILES O[C@@H](Cc1cccc(c1)-c1ccccn1)\C=C\[C@H]1CCC(=O)N1CCSCCCC(O)=O |r|
Show InChI InChI=1S/C25H30N2O4S/c28-22(18-19-5-3-6-20(17-19)23-7-1-2-13-26-23)11-9-21-10-12-24(29)27(21)14-16-32-15-4-8-25(30)31/h1-3,5-7,9,11,13,17,21-22,28H,4,8,10,12,14-16,18H2,(H,30,31)/b11-9+/t21-,22+/m0/s1
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 4.80n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP4 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Mus musculus (Mouse))		BDBM50385129
PNG
(CHEMBL2036319)
Show SMILES COc1ccc(cc1)-c1cccc(C[C@H](O)\C=C\[C@H]2CCC(=O)N2CCSc2nc(cs2)C(O)=O)c1 |r|
Show InChI InChI=1S/C27H28N2O5S2/c1-34-23-10-5-19(6-11-23)20-4-2-3-18(15-20)16-22(30)9-7-21-8-12-25(31)29(21)13-14-35-27-28-24(17-36-27)26(32)33/h2-7,9-11,15,17,21-22,30H,8,12-14,16H2,1H3,(H,32,33)/b9-7+/t21-,22+/m0/s1
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 9.20n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Mus musculus (Mouse))		BDBM50360626
PNG
(CHEMBL1933722)
Show SMILES Cc1cccc(C[C@H](O)\C=C\[C@H]2CCC(=O)N2CCSc2nc(cs2)C(O)=O)c1 |r|
Show InChI InChI=1S/C21H24N2O4S2/c1-14-3-2-4-15(11-14)12-17(24)7-5-16-6-8-19(25)23(16)9-10-28-21-22-18(13-29-21)20(26)27/h2-5,7,11,13,16-17,24H,6,8-10,12H2,1H3,(H,26,27)/b7-5+/t16-,17+/m0/s1
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 9.30n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Mus musculus (Mouse))		BDBM50385133
PNG
(CHEMBL2036324)
Show SMILES O[C@@H](Cc1cccc(c1)-c1nc2ccccc2s1)\C=C\[C@H]1CCC(=O)N1CCSc1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C27H25N3O4S3/c31-20(15-17-4-3-5-18(14-17)25-28-21-6-1-2-7-23(21)37-25)10-8-19-9-11-24(32)30(19)12-13-35-27-29-22(16-36-27)26(33)34/h1-8,10,14,16,19-20,31H,9,11-13,15H2,(H,33,34)/b10-8+/t19-,20+/m0/s1
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 15n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Mus musculus (Mouse))		BDBM50385135
PNG
(CHEMBL2036326)
Show SMILES Cc1ccc2oc(nc2c1)-c1cccc(C[C@H](O)\C=C\[C@H]2CCC(=O)N2CCSc2nc(cs2)C(O)=O)c1 |r|
Show InChI InChI=1S/C28H27N3O5S2/c1-17-5-9-24-22(13-17)29-26(36-24)19-4-2-3-18(14-19)15-21(32)8-6-20-7-10-25(33)31(20)11-12-37-28-30-23(16-38-28)27(34)35/h2-6,8-9,13-14,16,20-21,32H,7,10-12,15H2,1H3,(H,34,35)/b8-6+/t20-,21+/m0/s1
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 21n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Mus musculus (Mouse))		BDBM50385137
PNG
(CHEMBL2037290)
Show SMILES Cc1cccc2oc(nc12)-c1cccc(C[C@H](O)\C=C\[C@H]2CCC(=O)N2CCSc2nc(cs2)C(O)=O)c1 |r|
Show InChI InChI=1S/C28H27N3O5S2/c1-17-4-2-7-23-25(17)30-26(36-23)19-6-3-5-18(14-19)15-21(32)10-8-20-9-11-24(33)31(20)12-13-37-28-29-22(16-38-28)27(34)35/h2-8,10,14,16,20-21,32H,9,11-13,15H2,1H3,(H,34,35)/b10-8+/t20-,21+/m0/s1
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 22n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Mus musculus (Mouse))		BDBM50385134
PNG
(CHEMBL2036325)
Show SMILES O[C@@H](Cc1cccc(c1)-c1nc2cc(Cl)ccc2s1)\C=C\[C@H]1CCC(=O)N1CCSc1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C27H24ClN3O4S3/c28-18-4-8-23-21(14-18)29-25(38-23)17-3-1-2-16(12-17)13-20(32)7-5-19-6-9-24(33)31(19)10-11-36-27-30-22(15-37-27)26(34)35/h1-5,7-8,12,14-15,19-20,32H,6,9-11,13H2,(H,34,35)/b7-5+/t19-,20+/m0/s1
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 22n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Mus musculus (Mouse))		BDBM50366138
PNG
(CHEMBL1957437)
Show SMILES O[C@@H](Cc1cccc(c1)-c1ccc2ccccc2c1)\C=C\[C@H]1CCC(=O)N1CCSc1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C30H28N2O4S2/c33-26(17-20-4-3-7-22(16-20)24-9-8-21-5-1-2-6-23(21)18-24)12-10-25-11-13-28(34)32(25)14-15-37-30-31-27(19-38-30)29(35)36/h1-10,12,16,18-19,25-26,33H,11,13-15,17H2,(H,35,36)/b12-10+/t25-,26+/m0/s1
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 22n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Mus musculus (Mouse))		BDBM50385130
PNG
(CHEMBL2036320)
Show SMILES Cc1ccc(c(C)c1)-c1cccc(C[C@H](O)\C=C\[C@H]2CCC(=O)N2CCSc2nc(cs2)C(O)=O)c1 |r|
Show InChI InChI=1S/C28H30N2O4S2/c1-18-6-10-24(19(2)14-18)21-5-3-4-20(15-21)16-23(31)9-7-22-8-11-26(32)30(22)12-13-35-28-29-25(17-36-28)27(33)34/h3-7,9-10,14-15,17,22-23,31H,8,11-13,16H2,1-2H3,(H,33,34)/b9-7+/t22-,23+/m0/s1
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 23n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Mus musculus (Mouse))		BDBM50385138
PNG
(CHEMBL2037291)
Show SMILES Cc1cc(C)c2oc(nc2c1)-c1cccc(C[C@H](O)\C=C\[C@H]2CCC(=O)N2CCSc2nc(cs2)C(O)=O)c1 |r|
Show InChI InChI=1S/C29H29N3O5S2/c1-17-12-18(2)26-23(13-17)30-27(37-26)20-5-3-4-19(14-20)15-22(33)8-6-21-7-9-25(34)32(21)10-11-38-29-31-24(16-39-29)28(35)36/h3-6,8,12-14,16,21-22,33H,7,9-11,15H2,1-2H3,(H,35,36)/b8-6+/t21-,22+/m0/s1
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 24n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Mus musculus (Mouse))		BDBM50385127
PNG
(CHEMBL2036317)
Show SMILES O[C@@H](Cc1cccc(OCc2ccncc2)c1)\C=C\[C@H]1CCC(=O)N1CCSCCCC(O)=O |r|
Show InChI InChI=1S/C26H32N2O5S/c29-23(17-21-3-1-4-24(18-21)33-19-20-10-12-27-13-11-20)8-6-22-7-9-25(30)28(22)14-16-34-15-2-5-26(31)32/h1,3-4,6,8,10-13,18,22-23,29H,2,5,7,9,14-17,19H2,(H,31,32)/b8-6+/t22-,23+/m0/s1
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 28n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP4 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Mus musculus (Mouse))		BDBM50385132
PNG
(CHEMBL2036323)
Show SMILES O[C@@H](Cc1cccc(c1)-c1nc2ccccc2o1)\C=C\[C@H]1CCC(=O)N1CCSc1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C27H25N3O5S2/c31-20(15-17-4-3-5-18(14-17)25-28-21-6-1-2-7-23(21)35-25)10-8-19-9-11-24(32)30(19)12-13-36-27-29-22(16-37-27)26(33)34/h1-8,10,14,16,19-20,31H,9,11-13,15H2,(H,33,34)/b10-8+/t19-,20+/m0/s1
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 28n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Mus musculus (Mouse))		BDBM50385136
PNG
(CHEMBL2037289)
Show SMILES Cc1ccc2nc(oc2c1)-c1cccc(C[C@H](O)\C=C\[C@H]2CCC(=O)N2CCSc2nc(cs2)C(O)=O)c1 |r|
Show InChI InChI=1S/C28H27N3O5S2/c1-17-5-9-22-24(13-17)36-26(29-22)19-4-2-3-18(14-19)15-21(32)8-6-20-7-10-25(33)31(20)11-12-37-28-30-23(16-38-28)27(34)35/h2-6,8-9,13-14,16,20-21,32H,7,10-12,15H2,1H3,(H,34,35)/b8-6+/t20-,21+/m0/s1
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 56n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Mus musculus (Mouse))		BDBM50385139
PNG
(CHEMBL2037292)
Show SMILES O[C@@H](Cc1cccc(c1)-c1nc2cc(Cl)ccc2o1)\C=C\[C@H]1CCC(=O)N1CCSc1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C27H24ClN3O5S2/c28-18-4-8-23-21(14-18)29-25(36-23)17-3-1-2-16(12-17)13-20(32)7-5-19-6-9-24(33)31(19)10-11-37-27-30-22(15-38-27)26(34)35/h1-5,7-8,12,14-15,19-20,32H,6,9-11,13H2,(H,34,35)/b7-5+/t19-,20+/m0/s1
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 67n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype


(Mus musculus (Mouse))		BDBM50385136
PNG
(CHEMBL2037289)
Show SMILES Cc1ccc2nc(oc2c1)-c1cccc(C[C@H](O)\C=C\[C@H]2CCC(=O)N2CCSc2nc(cs2)C(O)=O)c1 |r|
Show InChI InChI=1S/C28H27N3O5S2/c1-17-5-9-22-24(13-17)36-26(29-22)19-4-2-3-18(14-19)15-21(32)8-6-20-7-10-25(33)31(20)11-12-37-28-30-23(16-38-28)27(34)35/h2-6,8-9,13-14,16,20-21,32H,7,10-12,15H2,1H3,(H,34,35)/b8-6+/t20-,21+/m0/s1
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 200n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP1 receptor expressed in CHO cells after 20 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Mus musculus (Mouse))		BDBM50360626
PNG
(CHEMBL1933722)
Show SMILES Cc1cccc(C[C@H](O)\C=C\[C@H]2CCC(=O)N2CCSc2nc(cs2)C(O)=O)c1 |r|
Show InChI InChI=1S/C21H24N2O4S2/c1-14-3-2-4-15(11-14)12-17(24)7-5-16-6-8-19(25)23(16)9-10-28-21-22-18(13-29-21)20(26)27/h2-5,7,11,13,16-17,24H,6,8-10,12H2,1H3,(H,26,27)/b7-5+/t16-,17+/m0/s1
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 540n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP3 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype


(Mus musculus (Mouse))		BDBM50385139
PNG
(CHEMBL2037292)
Show SMILES O[C@@H](Cc1cccc(c1)-c1nc2cc(Cl)ccc2o1)\C=C\[C@H]1CCC(=O)N1CCSc1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C27H24ClN3O5S2/c28-18-4-8-23-21(14-18)29-25(36-23)17-3-1-2-16(12-17)13-20(32)7-5-19-6-9-24(33)31(19)10-11-37-27-30-22(15-38-27)26(34)35/h1-5,7-8,12,14-15,19-20,32H,6,9-11,13H2,(H,34,35)/b7-5+/t19-,20+/m0/s1
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 650n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP1 receptor expressed in CHO cells after 20 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype


(Mus musculus (Mouse))		BDBM50385134
PNG
(CHEMBL2036325)
Show SMILES O[C@@H](Cc1cccc(c1)-c1nc2cc(Cl)ccc2s1)\C=C\[C@H]1CCC(=O)N1CCSc1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C27H24ClN3O4S3/c28-18-4-8-23-21(14-18)29-25(38-23)17-3-1-2-16(12-17)13-20(32)7-5-19-6-9-24(33)31(19)10-11-36-27-30-22(15-37-27)26(34)35/h1-5,7-8,12,14-15,19-20,32H,6,9-11,13H2,(H,34,35)/b7-5+/t19-,20+/m0/s1
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 680n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP1 receptor expressed in CHO cells after 20 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Mus musculus (Mouse))		BDBM50385123
PNG
(CHEMBL2036313)
Show SMILES O[C@@H](Cc1cccc(c1)-c1nc2ccccc2s1)\C=C\[C@H]1CCC(=O)N1CCSCCCC(O)=O |r|
Show InChI InChI=1S/C27H30N2O4S2/c30-22(12-10-21-11-13-25(31)29(21)14-16-34-15-4-9-26(32)33)18-19-5-3-6-20(17-19)27-28-23-7-1-2-8-24(23)35-27/h1-3,5-8,10,12,17,21-22,30H,4,9,11,13-16,18H2,(H,32,33)/b12-10+/t21-,22+/m0/s1
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 720n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype


(Mus musculus (Mouse))		BDBM50385135
PNG
(CHEMBL2036326)
Show SMILES Cc1ccc2oc(nc2c1)-c1cccc(C[C@H](O)\C=C\[C@H]2CCC(=O)N2CCSc2nc(cs2)C(O)=O)c1 |r|
Show InChI InChI=1S/C28H27N3O5S2/c1-17-5-9-24-22(13-17)29-26(36-24)19-4-2-3-18(14-19)15-21(32)8-6-20-7-10-25(33)31(20)11-12-37-28-30-23(16-38-28)27(34)35/h2-6,8-9,13-14,16,20-21,32H,7,10-12,15H2,1H3,(H,34,35)/b8-6+/t20-,21+/m0/s1
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 1.30E+3n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP1 receptor expressed in CHO cells after 20 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Mus musculus (Mouse))		BDBM50385131
PNG
(CHEMBL2036322)
Show SMILES O[C@@H](Cc1cccc(c1)-c1cc2ccccc2o1)\C=C\[C@H]1CCC(=O)N1CCSc1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C28H26N2O5S2/c31-22(15-18-4-3-6-19(14-18)25-16-20-5-1-2-7-24(20)35-25)10-8-21-9-11-26(32)30(21)12-13-36-28-29-23(17-37-28)27(33)34/h1-8,10,14,16-17,21-22,31H,9,11-13,15H2,(H,33,34)/b10-8+/t21-,22+/m0/s1
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 1.70E+3n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP3 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Mus musculus (Mouse))		BDBM50385122
PNG
(CHEMBL2036312)
Show SMILES O[C@@H](Cc1cccc(c1)-c1nc2ccccc2o1)\C=C\[C@H]1CCC(=O)N1CCSCCCC(O)=O |r|
Show InChI InChI=1S/C27H30N2O5S/c30-22(12-10-21-11-13-25(31)29(21)14-16-35-15-4-9-26(32)33)18-19-5-3-6-20(17-19)27-28-23-7-1-2-8-24(23)34-27/h1-3,5-8,10,12,17,21-22,30H,4,9,11,13-16,18H2,(H,32,33)/b12-10+/t21-,22+/m0/s1
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 1.70E+3n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Mus musculus (Mouse))		BDBM50385124
PNG
(CHEMBL2036314)
Show SMILES O[C@@H](Cc1cccc(c1)-c1cc2ccccc2o1)\C=C\[C@H]1CCC(=O)N1CCSCCCC(O)=O |r|
Show InChI InChI=1S/C28H31NO5S/c30-24(12-10-23-11-13-27(31)29(23)14-16-35-15-4-9-28(32)33)18-20-5-3-7-21(17-20)26-19-22-6-1-2-8-25(22)34-26/h1-3,5-8,10,12,17,19,23-24,30H,4,9,11,13-16,18H2,(H,32,33)/b12-10+/t23-,24+/m0/s1
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 2.00E+3n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Mus musculus (Mouse))		BDBM50385118
PNG
(CHEMBL2036308)
Show SMILES O[C@@H](Cc1cccc(c1)-c1ccc2ccccc2c1)\C=C\[C@H]1CCC(=O)N1CCSCCCC(O)=O |r|
Show InChI InChI=1S/C30H33NO4S/c32-28(14-12-27-13-15-29(33)31(27)16-18-36-17-4-9-30(34)35)20-22-5-3-8-24(19-22)26-11-10-23-6-1-2-7-25(23)21-26/h1-3,5-8,10-12,14,19,21,27-28,32H,4,9,13,15-18,20H2,(H,34,35)/b14-12+/t27-,28+/m0/s1
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 2.10E+3n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype


(Mus musculus (Mouse))		BDBM50385130
PNG
(CHEMBL2036320)
Show SMILES Cc1ccc(c(C)c1)-c1cccc(C[C@H](O)\C=C\[C@H]2CCC(=O)N2CCSc2nc(cs2)C(O)=O)c1 |r|
Show InChI InChI=1S/C28H30N2O4S2/c1-18-6-10-24(19(2)14-18)21-5-3-4-20(15-21)16-23(31)9-7-22-8-11-26(32)30(22)12-13-35-28-29-25(17-36-28)27(33)34/h3-7,9-10,14-15,17,22-23,31H,8,11-13,16H2,1-2H3,(H,33,34)/b9-7+/t22-,23+/m0/s1
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 2.40E+3n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP1 receptor expressed in CHO cells after 20 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype


(Mus musculus (Mouse))		BDBM50385141
PNG
(CHEMBL2036321)
Show SMILES Cc1ccc(cc1C)-c1cccc(C[C@H](O)\C=C\[C@H]2CCC(=O)N2CCSc2nc(cs2)C(O)=O)c1 |r|
Show InChI InChI=1S/C28H30N2O4S2/c1-18-6-7-22(14-19(18)2)21-5-3-4-20(15-21)16-24(31)10-8-23-9-11-26(32)30(23)12-13-35-28-29-25(17-36-28)27(33)34/h3-8,10,14-15,17,23-24,31H,9,11-13,16H2,1-2H3,(H,33,34)/b10-8+/t23-,24+/m0/s1
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 2.50E+3n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP1 receptor expressed in CHO cells after 20 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype


(Mus musculus (Mouse))		BDBM50385131
PNG
(CHEMBL2036322)
Show SMILES O[C@@H](Cc1cccc(c1)-c1cc2ccccc2o1)\C=C\[C@H]1CCC(=O)N1CCSc1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C28H26N2O5S2/c31-22(15-18-4-3-6-19(14-18)25-16-20-5-1-2-7-24(20)35-25)10-8-21-9-11-26(32)30(21)12-13-36-28-29-23(17-37-28)27(33)34/h1-8,10,14,16-17,21-22,31H,9,11-13,15H2,(H,33,34)/b10-8+/t21-,22+/m0/s1
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 2.70E+3n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP1 receptor expressed in CHO cells after 20 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype


(Mus musculus (Mouse))		BDBM50385138
PNG
(CHEMBL2037291)
Show SMILES Cc1cc(C)c2oc(nc2c1)-c1cccc(C[C@H](O)\C=C\[C@H]2CCC(=O)N2CCSc2nc(cs2)C(O)=O)c1 |r|
Show InChI InChI=1S/C29H29N3O5S2/c1-17-12-18(2)26-23(13-17)30-27(37-26)20-5-3-4-19(14-20)15-22(33)8-6-21-7-9-25(34)32(21)10-11-38-29-31-24(16-39-29)28(35)36/h3-6,8,12-14,16,21-22,33H,7,9-11,15H2,1-2H3,(H,35,36)/b8-6+/t21-,22+/m0/s1
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 3.20E+3n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP1 receptor expressed in CHO cells after 20 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Mus musculus (Mouse))		BDBM50385121
PNG
(CHEMBL2036311)
Show SMILES O[C@@H](Cc1cccc(c1)-c1ccc2[nH]ccc2c1)\C=C\[C@H]1CCC(=O)N1CCSCCCC(O)=O |r|
Show InChI InChI=1S/C28H32N2O4S/c31-25(9-7-24-8-11-27(32)30(24)14-16-35-15-2-5-28(33)34)18-20-3-1-4-21(17-20)22-6-10-26-23(19-22)12-13-29-26/h1,3-4,6-7,9-10,12-13,17,19,24-25,29,31H,2,5,8,11,14-16,18H2,(H,33,34)/b9-7+/t24-,25+/m0/s1
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 3.50E+3n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype


(Mus musculus (Mouse))		BDBM50366136
PNG
(CHEMBL1957435)
Show SMILES O[C@@H](Cc1cccc(c1)-c1ccccc1)\C=C\[C@H]1CCC(=O)N1CCSc1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C26H26N2O4S2/c29-22(16-18-5-4-8-20(15-18)19-6-2-1-3-7-19)11-9-21-10-12-24(30)28(21)13-14-33-26-27-23(17-34-26)25(31)32/h1-9,11,15,17,21-22,29H,10,12-14,16H2,(H,31,32)/b11-9+/t21-,22+/m0/s1
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 4.20E+3n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP1 receptor expressed in CHO cells after 20 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Mus musculus (Mouse))		BDBM50366136
PNG
(CHEMBL1957435)
Show SMILES O[C@@H](Cc1cccc(c1)-c1ccccc1)\C=C\[C@H]1CCC(=O)N1CCSc1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C26H26N2O4S2/c29-22(16-18-5-4-8-20(15-18)19-6-2-1-3-7-19)11-9-21-10-12-24(30)28(21)13-14-33-26-27-23(17-34-26)25(31)32/h1-9,11,15,17,21-22,29H,10,12-14,16H2,(H,31,32)/b11-9+/t21-,22+/m0/s1
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 4.30E+3n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP3 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype


(Mus musculus (Mouse))		BDBM50385122
PNG
(CHEMBL2036312)
Show SMILES O[C@@H](Cc1cccc(c1)-c1nc2ccccc2o1)\C=C\[C@H]1CCC(=O)N1CCSCCCC(O)=O |r|
Show InChI InChI=1S/C27H30N2O5S/c30-22(12-10-21-11-13-25(31)29(21)14-16-35-15-4-9-26(32)33)18-19-5-3-6-20(17-19)27-28-23-7-1-2-8-24(23)34-27/h1-3,5-8,10,12,17,21-22,30H,4,9,11,13-16,18H2,(H,32,33)/b12-10+/t21-,22+/m0/s1
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 5.00E+3n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP1 receptor expressed in CHO cells after 20 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype


(Mus musculus (Mouse))		BDBM50385129
PNG
(CHEMBL2036319)
Show SMILES COc1ccc(cc1)-c1cccc(C[C@H](O)\C=C\[C@H]2CCC(=O)N2CCSc2nc(cs2)C(O)=O)c1 |r|
Show InChI InChI=1S/C27H28N2O5S2/c1-34-23-10-5-19(6-11-23)20-4-2-3-18(15-20)16-22(30)9-7-21-8-12-25(31)29(21)13-14-35-27-28-24(17-36-27)26(32)33/h2-7,9-11,15,17,21-22,30H,8,12-14,16H2,1H3,(H,32,33)/b9-7+/t21-,22+/m0/s1
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 5.40E+3n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP1 receptor expressed in CHO cells after 20 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Mus musculus (Mouse))		BDBM50360621
PNG
(CHEMBL1933717)
Show SMILES Cc1cccc(C[C@H](O)\C=C\[C@H]2CCC(=O)N2CCSCCCC(O)=O)c1 |r|
Show InChI InChI=1S/C21H29NO4S/c1-16-4-2-5-17(14-16)15-19(23)9-7-18-8-10-20(24)22(18)11-13-27-12-3-6-21(25)26/h2,4-5,7,9,14,18-19,23H,3,6,8,10-13,15H2,1H3,(H,25,26)/b9-7+/t18-,19+/m0/s1
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 5.80E+3n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP3 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Mus musculus (Mouse))		BDBM50385119
PNG
(CHEMBL2036309)
Show SMILES O[C@@H](Cc1cccc(c1)-c1ccccn1)\C=C\[C@H]1CCC(=O)N1CCSCCCC(O)=O |r|
Show InChI InChI=1S/C25H30N2O4S/c28-22(18-19-5-3-6-20(17-19)23-7-1-2-13-26-23)11-9-21-10-12-24(29)27(21)14-16-32-15-4-8-25(30)31/h1-3,5-7,9,11,13,17,21-22,28H,4,8,10,12,14-16,18H2,(H,30,31)/b11-9+/t21-,22+/m0/s1
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 6.10E+3n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype


(Mus musculus (Mouse))		BDBM50385128
PNG
(CHEMBL2036318)
Show SMILES Cc1ccc(cc1)-c1cccc(C[C@H](O)\C=C\[C@H]2CCC(=O)N2CCSc2nc(cs2)C(O)=O)c1 |r|
Show InChI InChI=1S/C27H28N2O4S2/c1-18-5-7-20(8-6-18)21-4-2-3-19(15-21)16-23(30)11-9-22-10-12-25(31)29(22)13-14-34-27-28-24(17-35-27)26(32)33/h2-9,11,15,17,22-23,30H,10,12-14,16H2,1H3,(H,32,33)/b11-9+/t22-,23+/m0/s1
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 6.10E+3n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP1 receptor expressed in CHO cells after 20 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype


(Mus musculus (Mouse))		BDBM50366137
PNG
(CHEMBL1957436)
Show SMILES O[C@@H](Cc1cccc(c1)-c1ccc(Cl)cc1)\C=C\[C@H]1CCC(=O)N1CCSc1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C26H25ClN2O4S2/c27-20-6-4-18(5-7-20)19-3-1-2-17(14-19)15-22(30)10-8-21-9-11-24(31)29(21)12-13-34-26-28-23(16-35-26)25(32)33/h1-8,10,14,16,21-22,30H,9,11-13,15H2,(H,32,33)/b10-8+/t21-,22+/m0/s1
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 6.30E+3n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP1 receptor expressed in CHO cells after 20 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype


(Mus musculus (Mouse))		BDBM50385120
PNG
(CHEMBL2036310)
Show SMILES O[C@@H](Cc1cccc(c1)N1Cc2ccccc2C1)\C=C\[C@H]1CCC(=O)N1CCSCCCC(O)=O |r|
Show InChI InChI=1S/C28H34N2O4S/c31-26(12-10-24-11-13-27(32)30(24)14-16-35-15-4-9-28(33)34)18-21-5-3-8-25(17-21)29-19-22-6-1-2-7-23(22)20-29/h1-3,5-8,10,12,17,24,26,31H,4,9,11,13-16,18-20H2,(H,33,34)/b12-10+/t24-,26+/m0/s1
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 7.10E+3n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP1 receptor expressed in CHO cells after 20 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype


(Mus musculus (Mouse))		BDBM50385137
PNG
(CHEMBL2037290)
Show SMILES Cc1cccc2oc(nc12)-c1cccc(C[C@H](O)\C=C\[C@H]2CCC(=O)N2CCSc2nc(cs2)C(O)=O)c1 |r|
Show InChI InChI=1S/C28H27N3O5S2/c1-17-4-2-7-23-25(17)30-26(36-23)19-6-3-5-18(14-19)15-21(32)10-8-20-9-11-24(33)31(20)12-13-37-28-29-22(16-38-28)27(34)35/h2-8,10,14,16,20-21,32H,9,11-13,15H2,1H3,(H,34,35)/b10-8+/t20-,21+/m0/s1
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 7.70E+3n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP1 receptor expressed in CHO cells after 20 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype


(Mus musculus (Mouse))		BDBM50385133
PNG
(CHEMBL2036324)
Show SMILES O[C@@H](Cc1cccc(c1)-c1nc2ccccc2s1)\C=C\[C@H]1CCC(=O)N1CCSc1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C27H25N3O4S3/c31-20(15-17-4-3-5-18(14-17)25-28-21-6-1-2-7-23(21)37-25)10-8-19-9-11-24(32)30(19)12-13-35-27-29-22(16-36-27)26(33)34/h1-8,10,14,16,19-20,31H,9,11-13,15H2,(H,33,34)/b10-8+/t19-,20+/m0/s1
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 8.00E+3n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP1 receptor expressed in CHO cells after 20 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Mus musculus (Mouse))		BDBM50385118
PNG
(CHEMBL2036308)
Show SMILES O[C@@H](Cc1cccc(c1)-c1ccc2ccccc2c1)\C=C\[C@H]1CCC(=O)N1CCSCCCC(O)=O |r|
Show InChI InChI=1S/C30H33NO4S/c32-28(14-12-27-13-15-29(33)31(27)16-18-36-17-4-9-30(34)35)20-22-5-3-8-24(19-22)26-11-10-23-6-1-2-7-25(23)21-26/h1-3,5-8,10-12,14,19,21,27-28,32H,4,9,13,15-18,20H2,(H,34,35)/b14-12+/t27-,28+/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP3 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Mus musculus (Mouse))		BDBM50385141
PNG
(CHEMBL2036321)
Show SMILES Cc1ccc(cc1C)-c1cccc(C[C@H](O)\C=C\[C@H]2CCC(=O)N2CCSc2nc(cs2)C(O)=O)c1 |r|
Show InChI InChI=1S/C28H30N2O4S2/c1-18-6-7-22(14-19(18)2)21-5-3-4-20(15-21)16-24(31)10-8-23-9-11-26(32)30(23)12-13-35-28-29-25(17-36-28)27(33)34/h3-8,10,14-15,17,23-24,31H,9,11-13,16H2,1-2H3,(H,33,34)/b10-8+/t23-,24+/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP3 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Mus musculus (Mouse))		BDBM50385134
PNG
(CHEMBL2036325)
Show SMILES O[C@@H](Cc1cccc(c1)-c1nc2cc(Cl)ccc2s1)\C=C\[C@H]1CCC(=O)N1CCSc1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C27H24ClN3O4S3/c28-18-4-8-23-21(14-18)29-25(38-23)17-3-1-2-16(12-17)13-20(32)7-5-19-6-9-24(33)31(19)10-11-36-27-30-22(15-37-27)26(34)35/h1-5,7-8,12,14-15,19-20,32H,6,9-11,13H2,(H,34,35)/b7-5+/t19-,20+/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP3 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Mus musculus (Mouse))		BDBM50385135
PNG
(CHEMBL2036326)
Show SMILES Cc1ccc2oc(nc2c1)-c1cccc(C[C@H](O)\C=C\[C@H]2CCC(=O)N2CCSc2nc(cs2)C(O)=O)c1 |r|
Show InChI InChI=1S/C28H27N3O5S2/c1-17-5-9-24-22(13-17)29-26(36-24)19-4-2-3-18(14-19)15-21(32)8-6-20-7-10-25(33)31(20)11-12-37-28-30-23(16-38-28)27(34)35/h2-6,8-9,13-14,16,20-21,32H,7,10-12,15H2,1H3,(H,34,35)/b8-6+/t20-,21+/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP3 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Mus musculus (Mouse))		BDBM50385137
PNG
(CHEMBL2037290)
Show SMILES Cc1cccc2oc(nc12)-c1cccc(C[C@H](O)\C=C\[C@H]2CCC(=O)N2CCSc2nc(cs2)C(O)=O)c1 |r|
Show InChI InChI=1S/C28H27N3O5S2/c1-17-4-2-7-23-25(17)30-26(36-23)19-6-3-5-18(14-19)15-21(32)10-8-20-9-11-24(33)31(20)12-13-37-28-29-22(16-38-28)27(34)35/h2-8,10,14,16,20-21,32H,9,11-13,15H2,1H3,(H,34,35)/b10-8+/t20-,21+/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP3 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype


(Mus musculus (Mouse))		BDBM50385124
PNG
(CHEMBL2036314)
Show SMILES O[C@@H](Cc1cccc(c1)-c1cc2ccccc2o1)\C=C\[C@H]1CCC(=O)N1CCSCCCC(O)=O |r|
Show InChI InChI=1S/C28H31NO5S/c30-24(12-10-23-11-13-27(31)29(23)14-16-35-15-4-9-28(32)33)18-20-5-3-7-21(17-20)26-19-22-6-1-2-8-25(22)34-26/h1-3,5-8,10,12,17,19,23-24,30H,4,9,11,13-16,18H2,(H,32,33)/b12-10+/t23-,24+/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP1 receptor expressed in CHO cells after 20 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype


(Mus musculus (Mouse))		BDBM50385125
PNG
(CHEMBL2036315)
Show SMILES O[C@@H](Cc1cccc(OCc2cccnc2)c1)\C=C\[C@H]1CCC(=O)N1CCSCCCC(O)=O |r|
Show InChI InChI=1S/C26H32N2O5S/c29-23(16-20-4-1-6-24(17-20)33-19-21-5-2-12-27-18-21)10-8-22-9-11-25(30)28(22)13-15-34-14-3-7-26(31)32/h1-2,4-6,8,10,12,17-18,22-23,29H,3,7,9,11,13-16,19H2,(H,31,32)/b10-8+/t22-,23+/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP1 receptor expressed in CHO cells after 20 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Mus musculus (Mouse))		BDBM50385124
PNG
(CHEMBL2036314)
Show SMILES O[C@@H](Cc1cccc(c1)-c1cc2ccccc2o1)\C=C\[C@H]1CCC(=O)N1CCSCCCC(O)=O |r|
Show InChI InChI=1S/C28H31NO5S/c30-24(12-10-23-11-13-27(31)29(23)14-16-35-15-4-9-28(32)33)18-20-5-3-7-21(17-20)26-19-22-6-1-2-8-25(22)34-26/h1-3,5-8,10,12,17,19,23-24,30H,4,9,11,13-16,18H2,(H,32,33)/b12-10+/t23-,24+/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP3 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Mus musculus (Mouse))		BDBM50385130
PNG
(CHEMBL2036320)
Show SMILES Cc1ccc(c(C)c1)-c1cccc(C[C@H](O)\C=C\[C@H]2CCC(=O)N2CCSc2nc(cs2)C(O)=O)c1 |r|
Show InChI InChI=1S/C28H30N2O4S2/c1-18-6-10-24(19(2)14-18)21-5-3-4-20(15-21)16-23(31)9-7-22-8-11-26(32)30(22)12-13-35-28-29-25(17-36-28)27(33)34/h3-7,9-10,14-15,17,22-23,31H,8,11-13,16H2,1-2H3,(H,33,34)/b9-7+/t22-,23+/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP3 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Mus musculus (Mouse))		BDBM50385132
PNG
(CHEMBL2036323)
Show SMILES O[C@@H](Cc1cccc(c1)-c1nc2ccccc2o1)\C=C\[C@H]1CCC(=O)N1CCSc1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C27H25N3O5S2/c31-20(15-17-4-3-5-18(14-17)25-28-21-6-1-2-7-23(21)35-25)10-8-19-9-11-24(32)30(19)12-13-36-27-29-22(16-37-27)26(33)34/h1-8,10,14,16,19-20,31H,9,11-13,15H2,(H,33,34)/b10-8+/t19-,20+/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP3 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Mus musculus (Mouse))		BDBM50385123
PNG
(CHEMBL2036313)
Show SMILES O[C@@H](Cc1cccc(c1)-c1nc2ccccc2s1)\C=C\[C@H]1CCC(=O)N1CCSCCCC(O)=O |r|
Show InChI InChI=1S/C27H30N2O4S2/c30-22(12-10-21-11-13-25(31)29(21)14-16-34-15-4-9-26(32)33)18-19-5-3-6-20(17-19)27-28-23-7-1-2-8-24(23)35-27/h1-3,5-8,10,12,17,21-22,30H,4,9,11,13-16,18H2,(H,32,33)/b12-10+/t21-,22+/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP3 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype


(Mus musculus (Mouse))		BDBM50385119
PNG
(CHEMBL2036309)
Show SMILES O[C@@H](Cc1cccc(c1)-c1ccccn1)\C=C\[C@H]1CCC(=O)N1CCSCCCC(O)=O |r|
Show InChI InChI=1S/C25H30N2O4S/c28-22(18-19-5-3-6-20(17-19)23-7-1-2-13-26-23)11-9-21-10-12-24(29)27(21)14-16-32-15-4-8-25(30)31/h1-3,5-7,9,11,13,17,21-22,28H,4,8,10,12,14-16,18H2,(H,30,31)/b11-9+/t21-,22+/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP1 receptor expressed in CHO cells after 20 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype


(Mus musculus (Mouse))		BDBM50366138
PNG
(CHEMBL1957437)
Show SMILES O[C@@H](Cc1cccc(c1)-c1ccc2ccccc2c1)\C=C\[C@H]1CCC(=O)N1CCSc1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C30H28N2O4S2/c33-26(17-20-4-3-7-22(16-20)24-9-8-21-5-1-2-6-23(21)18-24)12-10-25-11-13-28(34)32(25)14-15-37-30-31-27(19-38-30)29(35)36/h1-10,12,16,18-19,25-26,33H,11,13-15,17H2,(H,35,36)/b12-10+/t25-,26+/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP1 receptor expressed in CHO cells after 20 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Mus musculus (Mouse))		BDBM50385120
PNG
(CHEMBL2036310)
Show SMILES O[C@@H](Cc1cccc(c1)N1Cc2ccccc2C1)\C=C\[C@H]1CCC(=O)N1CCSCCCC(O)=O |r|
Show InChI InChI=1S/C28H34N2O4S/c31-26(12-10-24-11-13-27(32)30(24)14-16-35-15-4-9-28(33)34)18-21-5-3-8-25(17-21)29-19-22-6-1-2-7-23(22)20-29/h1-3,5-8,10,12,17,24,26,31H,4,9,11,13-16,18-20H2,(H,33,34)/b12-10+/t24-,26+/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Mus musculus (Mouse))		BDBM50385126
PNG
(CHEMBL2036316)
Show SMILES O[C@@H](Cc1cccc(OCc2ccccn2)c1)\C=C\[C@H]1CCC(=O)N1CCSCCCC(O)=O |r|
Show InChI InChI=1S/C26H32N2O5S/c29-23(17-20-5-3-7-24(18-20)33-19-21-6-1-2-13-27-21)11-9-22-10-12-25(30)28(22)14-16-34-15-4-8-26(31)32/h1-3,5-7,9,11,13,18,22-23,29H,4,8,10,12,14-17,19H2,(H,31,32)/b11-9+/t22-,23+/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Mus musculus (Mouse))		BDBM50385140
PNG
(CHEMBL2036307)
Show SMILES O[C@@H](Cc1cccc(c1)-c1ccccc1)\C=C\[C@H]1CCC(=O)N1CCSCCCC(O)=O |r|
Show InChI InChI=1S/C26H31NO4S/c28-24(19-20-6-4-9-22(18-20)21-7-2-1-3-8-21)13-11-23-12-14-25(29)27(23)15-17-32-16-5-10-26(30)31/h1-4,6-9,11,13,18,23-24,28H,5,10,12,14-17,19H2,(H,30,31)/b13-11+/t23-,24+/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP3 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Mus musculus (Mouse))		BDBM50385120
PNG
(CHEMBL2036310)
Show SMILES O[C@@H](Cc1cccc(c1)N1Cc2ccccc2C1)\C=C\[C@H]1CCC(=O)N1CCSCCCC(O)=O |r|
Show InChI InChI=1S/C28H34N2O4S/c31-26(12-10-24-11-13-27(32)30(24)14-16-35-15-4-9-28(33)34)18-21-5-3-8-25(17-21)29-19-22-6-1-2-7-23(22)20-29/h1-3,5-8,10,12,17,24,26,31H,4,9,11,13-16,18-20H2,(H,33,34)/b12-10+/t24-,26+/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP3 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Mus musculus (Mouse))		BDBM50385127
PNG
(CHEMBL2036317)
Show SMILES O[C@@H](Cc1cccc(OCc2ccncc2)c1)\C=C\[C@H]1CCC(=O)N1CCSCCCC(O)=O |r|
Show InChI InChI=1S/C26H32N2O5S/c29-23(17-21-3-1-4-24(18-21)33-19-20-10-12-27-13-11-20)8-6-22-7-9-25(30)28(22)14-16-34-15-2-5-26(31)32/h1,3-4,6,8,10-13,18,22-23,29H,2,5,7,9,14-17,19H2,(H,31,32)/b8-6+/t22-,23+/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP3 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Mus musculus (Mouse))		BDBM50385133
PNG
(CHEMBL2036324)
Show SMILES O[C@@H](Cc1cccc(c1)-c1nc2ccccc2s1)\C=C\[C@H]1CCC(=O)N1CCSc1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C27H25N3O4S3/c31-20(15-17-4-3-5-18(14-17)25-28-21-6-1-2-7-23(21)37-25)10-8-19-9-11-24(32)30(19)12-13-35-27-29-22(16-36-27)26(33)34/h1-8,10,14,16,19-20,31H,9,11-13,15H2,(H,33,34)/b10-8+/t19-,20+/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP3 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype


(Mus musculus (Mouse))		BDBM50385118
PNG
(CHEMBL2036308)
Show SMILES O[C@@H](Cc1cccc(c1)-c1ccc2ccccc2c1)\C=C\[C@H]1CCC(=O)N1CCSCCCC(O)=O |r|
Show InChI InChI=1S/C30H33NO4S/c32-28(14-12-27-13-15-29(33)31(27)16-18-36-17-4-9-30(34)35)20-22-5-3-8-24(19-22)26-11-10-23-6-1-2-7-25(23)21-26/h1-3,5-8,10-12,14,19,21,27-28,32H,4,9,13,15-18,20H2,(H,34,35)/b14-12+/t27-,28+/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP1 receptor expressed in CHO cells after 20 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype


(Mus musculus (Mouse))		BDBM50385132
PNG
(CHEMBL2036323)
Show SMILES O[C@@H](Cc1cccc(c1)-c1nc2ccccc2o1)\C=C\[C@H]1CCC(=O)N1CCSc1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C27H25N3O5S2/c31-20(15-17-4-3-5-18(14-17)25-28-21-6-1-2-7-23(21)35-25)10-8-19-9-11-24(32)30(19)12-13-36-27-29-22(16-37-27)26(33)34/h1-8,10,14,16,19-20,31H,9,11-13,15H2,(H,33,34)/b10-8+/t19-,20+/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP1 receptor expressed in CHO cells after 20 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Mus musculus (Mouse))		BDBM50385125
PNG
(CHEMBL2036315)
Show SMILES O[C@@H](Cc1cccc(OCc2cccnc2)c1)\C=C\[C@H]1CCC(=O)N1CCSCCCC(O)=O |r|
Show InChI InChI=1S/C26H32N2O5S/c29-23(16-20-4-1-6-24(17-20)33-19-21-5-2-12-27-18-21)10-8-22-9-11-25(30)28(22)13-15-34-14-3-7-26(31)32/h1-2,4-6,8,10,12,17-18,22-23,29H,3,7,9,11,13-16,19H2,(H,31,32)/b10-8+/t22-,23+/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP3 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Mus musculus (Mouse))		BDBM50385129
PNG
(CHEMBL2036319)
Show SMILES COc1ccc(cc1)-c1cccc(C[C@H](O)\C=C\[C@H]2CCC(=O)N2CCSc2nc(cs2)C(O)=O)c1 |r|
Show InChI InChI=1S/C27H28N2O5S2/c1-34-23-10-5-19(6-11-23)20-4-2-3-18(15-20)16-22(30)9-7-21-8-12-25(31)29(21)13-14-35-27-28-24(17-36-27)26(32)33/h2-7,9-11,15,17,21-22,30H,8,12-14,16H2,1H3,(H,32,33)/b9-7+/t21-,22+/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP3 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Mus musculus (Mouse))		BDBM50366138
PNG
(CHEMBL1957437)
Show SMILES O[C@@H](Cc1cccc(c1)-c1ccc2ccccc2c1)\C=C\[C@H]1CCC(=O)N1CCSc1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C30H28N2O4S2/c33-26(17-20-4-3-7-22(16-20)24-9-8-21-5-1-2-6-23(21)18-24)12-10-25-11-13-28(34)32(25)14-15-37-30-31-27(19-38-30)29(35)36/h1-10,12,16,18-19,25-26,33H,11,13-15,17H2,(H,35,36)/b12-10+/t25-,26+/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP3 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Mus musculus (Mouse))		BDBM50385138
PNG
(CHEMBL2037291)
Show SMILES Cc1cc(C)c2oc(nc2c1)-c1cccc(C[C@H](O)\C=C\[C@H]2CCC(=O)N2CCSc2nc(cs2)C(O)=O)c1 |r|
Show InChI InChI=1S/C29H29N3O5S2/c1-17-12-18(2)26-23(13-17)30-27(37-26)20-5-3-4-19(14-20)15-22(33)8-6-21-7-9-25(34)32(21)10-11-38-29-31-24(16-39-29)28(35)36/h3-6,8,12-14,16,21-22,33H,7,9-11,15H2,1-2H3,(H,35,36)/b8-6+/t21-,22+/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP3 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype


(Mus musculus (Mouse))		BDBM50360621
PNG
(CHEMBL1933717)
Show SMILES Cc1cccc(C[C@H](O)\C=C\[C@H]2CCC(=O)N2CCSCCCC(O)=O)c1 |r|
Show InChI InChI=1S/C21H29NO4S/c1-16-4-2-5-17(14-16)15-19(23)9-7-18-8-10-20(24)22(18)11-13-27-12-3-6-21(25)26/h2,4-5,7,9,14,18-19,23H,3,6,8,10-13,15H2,1H3,(H,25,26)/b9-7+/t18-,19+/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP1 receptor expressed in CHO cells after 20 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype


(Mus musculus (Mouse))		BDBM50385140
PNG
(CHEMBL2036307)
Show SMILES O[C@@H](Cc1cccc(c1)-c1ccccc1)\C=C\[C@H]1CCC(=O)N1CCSCCCC(O)=O |r|
Show InChI InChI=1S/C26H31NO4S/c28-24(19-20-6-4-9-22(18-20)21-7-2-1-3-8-21)13-11-23-12-14-25(29)27(23)15-17-32-16-5-10-26(30)31/h1-4,6-9,11,13,18,23-24,28H,5,10,12,14-17,19H2,(H,30,31)/b13-11+/t23-,24+/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP1 receptor expressed in CHO cells after 20 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype


(Mus musculus (Mouse))		BDBM50385126
PNG
(CHEMBL2036316)
Show SMILES O[C@@H](Cc1cccc(OCc2ccccn2)c1)\C=C\[C@H]1CCC(=O)N1CCSCCCC(O)=O |r|
Show InChI InChI=1S/C26H32N2O5S/c29-23(17-20-5-3-7-24(18-20)33-19-21-6-1-2-13-27-21)11-9-22-10-12-25(30)28(22)14-16-34-15-4-8-26(31)32/h1-3,5-7,9,11,13,18,22-23,29H,4,8,10,12,14-17,19H2,(H,31,32)/b11-9+/t22-,23+/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP1 receptor expressed in CHO cells after 20 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Mus musculus (Mouse))		BDBM50385119
PNG
(CHEMBL2036309)
Show SMILES O[C@@H](Cc1cccc(c1)-c1ccccn1)\C=C\[C@H]1CCC(=O)N1CCSCCCC(O)=O |r|
Show InChI InChI=1S/C25H30N2O4S/c28-22(18-19-5-3-6-20(17-19)23-7-1-2-13-26-23)11-9-21-10-12-24(29)27(21)14-16-32-15-4-8-25(30)31/h1-3,5-7,9,11,13,17,21-22,28H,4,8,10,12,14-16,18H2,(H,30,31)/b11-9+/t21-,22+/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP3 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype


(Mus musculus (Mouse))		BDBM50385127
PNG
(CHEMBL2036317)
Show SMILES O[C@@H](Cc1cccc(OCc2ccncc2)c1)\C=C\[C@H]1CCC(=O)N1CCSCCCC(O)=O |r|
Show InChI InChI=1S/C26H32N2O5S/c29-23(17-21-3-1-4-24(18-21)33-19-20-10-12-27-13-11-20)8-6-22-7-9-25(30)28(22)14-16-34-15-2-5-26(31)32/h1,3-4,6,8,10-13,18,22-23,29H,2,5,7,9,14-17,19H2,(H,31,32)/b8-6+/t22-,23+/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP1 receptor expressed in CHO cells after 20 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Mus musculus (Mouse))		BDBM50385136
PNG
(CHEMBL2037289)
Show SMILES Cc1ccc2nc(oc2c1)-c1cccc(C[C@H](O)\C=C\[C@H]2CCC(=O)N2CCSc2nc(cs2)C(O)=O)c1 |r|
Show InChI InChI=1S/C28H27N3O5S2/c1-17-5-9-22-24(13-17)36-26(29-22)19-4-2-3-18(14-19)15-21(32)8-6-20-7-10-25(33)31(20)11-12-37-28-30-23(16-38-28)27(34)35/h2-6,8-9,13-14,16,20-21,32H,7,10-12,15H2,1H3,(H,34,35)/b8-6+/t20-,21+/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP3 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype


(Mus musculus (Mouse))		BDBM50385121
PNG
(CHEMBL2036311)
Show SMILES O[C@@H](Cc1cccc(c1)-c1ccc2[nH]ccc2c1)\C=C\[C@H]1CCC(=O)N1CCSCCCC(O)=O |r|
Show InChI InChI=1S/C28H32N2O4S/c31-25(9-7-24-8-11-27(32)30(24)14-16-35-15-2-5-28(33)34)18-20-3-1-4-21(17-20)22-6-10-26-23(19-22)12-13-29-26/h1,3-4,6-7,9-10,12-13,17,19,24-25,29,31H,2,5,8,11,14-16,18H2,(H,33,34)/b9-7+/t24-,25+/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP1 receptor expressed in CHO cells after 20 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Mus musculus (Mouse))		BDBM50366137
PNG
(CHEMBL1957436)
Show SMILES O[C@@H](Cc1cccc(c1)-c1ccc(Cl)cc1)\C=C\[C@H]1CCC(=O)N1CCSc1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C26H25ClN2O4S2/c27-20-6-4-18(5-7-20)19-3-1-2-17(14-19)15-22(30)10-8-21-9-11-24(31)29(21)12-13-34-26-28-23(16-35-26)25(32)33/h1-8,10,14,16,21-22,30H,9,11-13,15H2,(H,32,33)/b10-8+/t21-,22+/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP3 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Mus musculus (Mouse))		BDBM50385127
PNG
(CHEMBL2036317)
Show SMILES O[C@@H](Cc1cccc(OCc2ccncc2)c1)\C=C\[C@H]1CCC(=O)N1CCSCCCC(O)=O |r|
Show InChI InChI=1S/C26H32N2O5S/c29-23(17-21-3-1-4-24(18-21)33-19-20-10-12-27-13-11-20)8-6-22-7-9-25(30)28(22)14-16-34-15-2-5-26(31)32/h1,3-4,6,8,10-13,18,22-23,29H,2,5,7,9,14-17,19H2,(H,31,32)/b8-6+/t22-,23+/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Mus musculus (Mouse))		BDBM50385122
PNG
(CHEMBL2036312)
Show SMILES O[C@@H](Cc1cccc(c1)-c1nc2ccccc2o1)\C=C\[C@H]1CCC(=O)N1CCSCCCC(O)=O |r|
Show InChI InChI=1S/C27H30N2O5S/c30-22(12-10-21-11-13-25(31)29(21)14-16-35-15-4-9-26(32)33)18-19-5-3-6-20(17-19)27-28-23-7-1-2-8-24(23)34-27/h1-3,5-8,10,12,17,21-22,30H,4,9,11,13-16,18H2,(H,32,33)/b12-10+/t21-,22+/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP3 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Mus musculus (Mouse))		BDBM50385139
PNG
(CHEMBL2037292)
Show SMILES O[C@@H](Cc1cccc(c1)-c1nc2cc(Cl)ccc2o1)\C=C\[C@H]1CCC(=O)N1CCSc1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C27H24ClN3O5S2/c28-18-4-8-23-21(14-18)29-25(36-23)17-3-1-2-16(12-17)13-20(32)7-5-19-6-9-24(33)31(19)10-11-37-27-30-22(15-38-27)26(34)35/h1-5,7-8,12,14-15,19-20,32H,6,9-11,13H2,(H,34,35)/b7-5+/t19-,20+/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP3 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Mus musculus (Mouse))		BDBM50360621
PNG
(CHEMBL1933717)
Show SMILES Cc1cccc(C[C@H](O)\C=C\[C@H]2CCC(=O)N2CCSCCCC(O)=O)c1 |r|
Show InChI InChI=1S/C21H29NO4S/c1-16-4-2-5-17(14-16)15-19(23)9-7-18-8-10-20(24)22(18)11-13-27-12-3-6-21(25)26/h2,4-5,7,9,14,18-19,23H,3,6,8,10-13,15H2,1H3,(H,25,26)/b9-7+/t18-,19+/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype


(Mus musculus (Mouse))		BDBM50385123
PNG
(CHEMBL2036313)
Show SMILES O[C@@H](Cc1cccc(c1)-c1nc2ccccc2s1)\C=C\[C@H]1CCC(=O)N1CCSCCCC(O)=O |r|
Show InChI InChI=1S/C27H30N2O4S2/c30-22(12-10-21-11-13-25(31)29(21)14-16-34-15-4-9-26(32)33)18-19-5-3-6-20(17-19)27-28-23-7-1-2-8-24(23)35-27/h1-3,5-8,10,12,17,21-22,30H,4,9,11,13-16,18H2,(H,32,33)/b12-10+/t21-,22+/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP1 receptor expressed in CHO cells after 20 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype


(Mus musculus (Mouse))		BDBM50360626
PNG
(CHEMBL1933722)
Show SMILES Cc1cccc(C[C@H](O)\C=C\[C@H]2CCC(=O)N2CCSc2nc(cs2)C(O)=O)c1 |r|
Show InChI InChI=1S/C21H24N2O4S2/c1-14-3-2-4-15(11-14)12-17(24)7-5-16-6-8-19(25)23(16)9-10-28-21-22-18(13-29-21)20(26)27/h2-5,7,11,13,16-17,24H,6,8-10,12H2,1H3,(H,26,27)/b7-5+/t16-,17+/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP1 receptor expressed in CHO cells after 20 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Mus musculus (Mouse))		BDBM50385125
PNG
(CHEMBL2036315)
Show SMILES O[C@@H](Cc1cccc(OCc2cccnc2)c1)\C=C\[C@H]1CCC(=O)N1CCSCCCC(O)=O |r|
Show InChI InChI=1S/C26H32N2O5S/c29-23(16-20-4-1-6-24(17-20)33-19-21-5-2-12-27-18-21)10-8-22-9-11-25(30)28(22)13-15-34-14-3-7-26(31)32/h1-2,4-6,8,10,12,17-18,22-23,29H,3,7,9,11,13-16,19H2,(H,31,32)/b10-8+/t22-,23+/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Mus musculus (Mouse))		BDBM50385121
PNG
(CHEMBL2036311)
Show SMILES O[C@@H](Cc1cccc(c1)-c1ccc2[nH]ccc2c1)\C=C\[C@H]1CCC(=O)N1CCSCCCC(O)=O |r|
Show InChI InChI=1S/C28H32N2O4S/c31-25(9-7-24-8-11-27(32)30(24)14-16-35-15-2-5-28(33)34)18-20-3-1-4-21(17-20)22-6-10-26-23(19-22)12-13-29-26/h1,3-4,6-7,9-10,12-13,17,19,24-25,29,31H,2,5,8,11,14-16,18H2,(H,33,34)/b9-7+/t24-,25+/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP3 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Mus musculus (Mouse))		BDBM50385126
PNG
(CHEMBL2036316)
Show SMILES O[C@@H](Cc1cccc(OCc2ccccn2)c1)\C=C\[C@H]1CCC(=O)N1CCSCCCC(O)=O |r|
Show InChI InChI=1S/C26H32N2O5S/c29-23(17-20-5-3-7-24(18-20)33-19-21-6-1-2-13-27-21)11-9-22-10-12-25(30)28(22)14-16-34-15-4-8-26(31)32/h1-3,5-7,9,11,13,18,22-23,29H,4,8,10,12,14-17,19H2,(H,31,32)/b11-9+/t22-,23+/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP3 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Mus musculus (Mouse))		BDBM50385128
PNG
(CHEMBL2036318)
Show SMILES Cc1ccc(cc1)-c1cccc(C[C@H](O)\C=C\[C@H]2CCC(=O)N2CCSc2nc(cs2)C(O)=O)c1 |r|
Show InChI InChI=1S/C27H28N2O4S2/c1-18-5-7-20(8-6-18)21-4-2-3-19(15-21)16-23(30)11-9-22-10-12-25(31)29(22)13-14-34-27-28-24(17-35-27)26(32)33/h2-9,11,15,17,22-23,30H,10,12-14,16H2,1H3,(H,32,33)/b11-9+/t22-,23+/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP3 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Mus musculus (Mouse))		BDBM50385140
PNG
(CHEMBL2036307)
Show SMILES O[C@@H](Cc1cccc(c1)-c1ccccc1)\C=C\[C@H]1CCC(=O)N1CCSCCCC(O)=O |r|
Show InChI InChI=1S/C26H31NO4S/c28-24(19-20-6-4-9-22(18-20)21-7-2-1-3-8-21)13-11-23-12-14-25(29)27(23)15-17-32-16-5-10-26(30)31/h1-4,6-9,11,13,18,23-24,28H,5,10,12,14-17,19H2,(H,30,31)/b13-11+/t23-,24+/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Rattus norvegicus)		BDBM50360626
PNG
(CHEMBL1933722)
Show SMILES Cc1cccc(C[C@H](O)\C=C\[C@H]2CCC(=O)N2CCSc2nc(cs2)C(O)=O)c1 |r|
Show InChI InChI=1S/C21H24N2O4S2/c1-14-3-2-4-15(11-14)12-17(24)7-5-16-6-8-19(25)23(16)9-10-28-21-22-18(13-29-21)20(26)27/h2-5,7,11,13,16-17,24H,6,8-10,12H2,1H3,(H,26,27)/b7-5+/t16-,17+/m0/s1
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n/an/an/an/a 90n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Rattus norvegicus)		BDBM50385136
PNG
(CHEMBL2037289)
Show SMILES Cc1ccc2nc(oc2c1)-c1cccc(C[C@H](O)\C=C\[C@H]2CCC(=O)N2CCSc2nc(cs2)C(O)=O)c1 |r|
Show InChI InChI=1S/C28H27N3O5S2/c1-17-5-9-22-24(13-17)36-26(29-22)19-4-2-3-18(14-19)15-21(32)8-6-20-7-10-25(33)31(20)11-12-37-28-30-23(16-38-28)27(34)35/h2-6,8-9,13-14,16,20-21,32H,7,10-12,15H2,1H3,(H,34,35)/b8-6+/t20-,21+/m0/s1
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n/an/an/an/a 1.60n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Rattus norvegicus)		BDBM50385139
PNG
(CHEMBL2037292)
Show SMILES O[C@@H](Cc1cccc(c1)-c1nc2cc(Cl)ccc2o1)\C=C\[C@H]1CCC(=O)N1CCSc1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C27H24ClN3O5S2/c28-18-4-8-23-21(14-18)29-25(36-23)17-3-1-2-16(12-17)13-20(32)7-5-19-6-9-24(33)31(19)10-11-37-27-30-22(15-38-27)26(34)35/h1-5,7-8,12,14-15,19-20,32H,6,9-11,13H2,(H,34,35)/b7-5+/t19-,20+/m0/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Rattus norvegicus)		BDBM50360626
PNG
(CHEMBL1933722)
Show SMILES Cc1cccc(C[C@H](O)\C=C\[C@H]2CCC(=O)N2CCSc2nc(cs2)C(O)=O)c1 |r|
Show InChI InChI=1S/C21H24N2O4S2/c1-14-3-2-4-15(11-14)12-17(24)7-5-16-6-8-19(25)23(16)9-10-28-21-22-18(13-29-21)20(26)27/h2-5,7,11,13,16-17,24H,6,8-10,12H2,1H3,(H,26,27)/b7-5+/t16-,17+/m0/s1
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n/an/an/an/a 0.790n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Rattus norvegicus)		BDBM50385128
PNG
(CHEMBL2036318)
Show SMILES Cc1ccc(cc1)-c1cccc(C[C@H](O)\C=C\[C@H]2CCC(=O)N2CCSc2nc(cs2)C(O)=O)c1 |r|
Show InChI InChI=1S/C27H28N2O4S2/c1-18-5-7-20(8-6-18)21-4-2-3-19(15-21)16-23(30)11-9-22-10-12-25(31)29(22)13-14-34-27-28-24(17-35-27)26(32)33/h2-9,11,15,17,22-23,30H,10,12-14,16H2,1H3,(H,32,33)/b11-9+/t22-,23+/m0/s1
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n/an/an/an/a 15n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Rattus norvegicus)		BDBM50366138
PNG
(CHEMBL1957437)
Show SMILES O[C@@H](Cc1cccc(c1)-c1ccc2ccccc2c1)\C=C\[C@H]1CCC(=O)N1CCSc1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C30H28N2O4S2/c33-26(17-20-4-3-7-22(16-20)24-9-8-21-5-1-2-6-23(21)18-24)12-10-25-11-13-28(34)32(25)14-15-37-30-31-27(19-38-30)29(35)36/h1-10,12,16,18-19,25-26,33H,11,13-15,17H2,(H,35,36)/b12-10+/t25-,26+/m0/s1
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Minase Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Rattus norvegicus)		BDBM50385124
PNG
(CHEMBL2036314)
Show SMILES O[C@@H](Cc1cccc(c1)-c1cc2ccccc2o1)\C=C\[C@H]1CCC(=O)N1CCSCCCC(O)=O |r|
Show InChI InChI=1S/C28H31NO5S/c30-24(12-10-23-11-13-27(31)29(23)14-16-35-15-4-9-28(32)33)18-20-5-3-7-21(17-20)26-19-22-6-1-2-8-25(22)34-26/h1-3,5-8,10,12,17,19,23-24,30H,4,9,11,13-16,18H2,(H,32,33)/b12-10+/t23-,24+/m0/s1
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n/an/an/an/a 7n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Rattus norvegicus)		BDBM50385131
PNG
(CHEMBL2036322)
Show SMILES O[C@@H](Cc1cccc(c1)-c1cc2ccccc2o1)\C=C\[C@H]1CCC(=O)N1CCSc1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C28H26N2O5S2/c31-22(15-18-4-3-6-19(14-18)25-16-20-5-1-2-7-24(20)35-25)10-8-21-9-11-26(32)30(21)12-13-36-28-29-23(17-37-28)27(33)34/h1-8,10,14,16-17,21-22,31H,9,11-13,15H2,(H,33,34)/b10-8+/t21-,22+/m0/s1
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n/an/an/an/a 5.30n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Rattus norvegicus)		BDBM50385134
PNG
(CHEMBL2036325)
Show SMILES O[C@@H](Cc1cccc(c1)-c1nc2cc(Cl)ccc2s1)\C=C\[C@H]1CCC(=O)N1CCSc1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C27H24ClN3O4S3/c28-18-4-8-23-21(14-18)29-25(38-23)17-3-1-2-16(12-17)13-20(32)7-5-19-6-9-24(33)31(19)10-11-36-27-30-22(15-37-27)26(34)35/h1-5,7-8,12,14-15,19-20,32H,6,9-11,13H2,(H,34,35)/b7-5+/t19-,20+/m0/s1
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n/an/an/an/a 9.70n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Rattus norvegicus)		BDBM50385137
PNG
(CHEMBL2037290)
Show SMILES Cc1cccc2oc(nc12)-c1cccc(C[C@H](O)\C=C\[C@H]2CCC(=O)N2CCSc2nc(cs2)C(O)=O)c1 |r|
Show InChI InChI=1S/C28H27N3O5S2/c1-17-4-2-7-23-25(17)30-26(36-23)19-6-3-5-18(14-19)15-21(32)10-8-20-9-11-24(33)31(20)12-13-37-28-29-22(16-38-28)27(34)35/h2-8,10,14,16,20-21,32H,9,11-13,15H2,1H3,(H,34,35)/b10-8+/t20-,21+/m0/s1
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n/an/an/an/a 28n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Rattus norvegicus)		BDBM50366136
PNG
(CHEMBL1957435)
Show SMILES O[C@@H](Cc1cccc(c1)-c1ccccc1)\C=C\[C@H]1CCC(=O)N1CCSc1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C26H26N2O4S2/c29-22(16-18-5-4-8-20(15-18)19-6-2-1-3-7-19)11-9-21-10-12-24(30)28(21)13-14-33-26-27-23(17-34-26)25(31)32/h1-9,11,15,17,21-22,29H,10,12-14,16H2,(H,31,32)/b11-9+/t21-,22+/m0/s1
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n/an/an/an/a 1.80E+3n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Rattus norvegicus)		BDBM50385133
PNG
(CHEMBL2036324)
Show SMILES O[C@@H](Cc1cccc(c1)-c1nc2ccccc2s1)\C=C\[C@H]1CCC(=O)N1CCSc1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C27H25N3O4S3/c31-20(15-17-4-3-5-18(14-17)25-28-21-6-1-2-7-23(21)37-25)10-8-19-9-11-24(32)30(19)12-13-35-27-29-22(16-36-27)26(33)34/h1-8,10,14,16,19-20,31H,9,11-13,15H2,(H,33,34)/b10-8+/t19-,20+/m0/s1
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n/an/an/an/a 2.70E+3n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Rattus norvegicus)		BDBM50385134
PNG
(CHEMBL2036325)
Show SMILES O[C@@H](Cc1cccc(c1)-c1nc2cc(Cl)ccc2s1)\C=C\[C@H]1CCC(=O)N1CCSc1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C27H24ClN3O4S3/c28-18-4-8-23-21(14-18)29-25(38-23)17-3-1-2-16(12-17)13-20(32)7-5-19-6-9-24(33)31(19)10-11-36-27-30-22(15-37-27)26(34)35/h1-5,7-8,12,14-15,19-20,32H,6,9-11,13H2,(H,34,35)/b7-5+/t19-,20+/m0/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Rattus norvegicus)		BDBM50385135
PNG
(CHEMBL2036326)
Show SMILES Cc1ccc2oc(nc2c1)-c1cccc(C[C@H](O)\C=C\[C@H]2CCC(=O)N2CCSc2nc(cs2)C(O)=O)c1 |r|
Show InChI InChI=1S/C28H27N3O5S2/c1-17-5-9-24-22(13-17)29-26(36-24)19-4-2-3-18(14-19)15-21(32)8-6-20-7-10-25(33)31(20)11-12-37-28-30-23(16-38-28)27(34)35/h2-6,8-9,13-14,16,20-21,32H,7,10-12,15H2,1H3,(H,34,35)/b8-6+/t20-,21+/m0/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Rattus norvegicus)		BDBM50385136
PNG
(CHEMBL2037289)
Show SMILES Cc1ccc2nc(oc2c1)-c1cccc(C[C@H](O)\C=C\[C@H]2CCC(=O)N2CCSc2nc(cs2)C(O)=O)c1 |r|
Show InChI InChI=1S/C28H27N3O5S2/c1-17-5-9-22-24(13-17)36-26(29-22)19-4-2-3-18(14-19)15-21(32)8-6-20-7-10-25(33)31(20)11-12-37-28-30-23(16-38-28)27(34)35/h2-6,8-9,13-14,16,20-21,32H,7,10-12,15H2,1H3,(H,34,35)/b8-6+/t20-,21+/m0/s1
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n/an/an/an/a 3.20E+3n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Rattus norvegicus)		BDBM50385138
PNG
(CHEMBL2037291)
Show SMILES Cc1cc(C)c2oc(nc2c1)-c1cccc(C[C@H](O)\C=C\[C@H]2CCC(=O)N2CCSc2nc(cs2)C(O)=O)c1 |r|
Show InChI InChI=1S/C29H29N3O5S2/c1-17-12-18(2)26-23(13-17)30-27(37-26)20-5-3-4-19(14-20)15-22(33)8-6-21-7-9-25(34)32(21)10-11-38-29-31-24(16-39-29)28(35)36/h3-6,8,12-14,16,21-22,33H,7,9-11,15H2,1-2H3,(H,35,36)/b8-6+/t21-,22+/m0/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Rattus norvegicus)		BDBM50385126
PNG
(CHEMBL2036316)
Show SMILES O[C@@H](Cc1cccc(OCc2ccccn2)c1)\C=C\[C@H]1CCC(=O)N1CCSCCCC(O)=O |r|
Show InChI InChI=1S/C26H32N2O5S/c29-23(17-20-5-3-7-24(18-20)33-19-21-6-1-2-13-27-21)11-9-22-10-12-25(30)28(22)14-16-34-15-4-8-26(31)32/h1-3,5-7,9,11,13,18,22-23,29H,4,8,10,12,14-17,19H2,(H,31,32)/b11-9+/t22-,23+/m0/s1
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n/an/an/an/a 0.610n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Rattus norvegicus)		BDBM50366138
PNG
(CHEMBL1957437)
Show SMILES O[C@@H](Cc1cccc(c1)-c1ccc2ccccc2c1)\C=C\[C@H]1CCC(=O)N1CCSc1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C30H28N2O4S2/c33-26(17-20-4-3-7-22(16-20)24-9-8-21-5-1-2-6-23(21)18-24)12-10-25-11-13-28(34)32(25)14-15-37-30-31-27(19-38-30)29(35)36/h1-10,12,16,18-19,25-26,33H,11,13-15,17H2,(H,35,36)/b12-10+/t25-,26+/m0/s1
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n/an/an/an/a 480n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Rattus norvegicus)		BDBM50385139
PNG
(CHEMBL2037292)
Show SMILES O[C@@H](Cc1cccc(c1)-c1nc2cc(Cl)ccc2o1)\C=C\[C@H]1CCC(=O)N1CCSc1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C27H24ClN3O5S2/c28-18-4-8-23-21(14-18)29-25(36-23)17-3-1-2-16(12-17)13-20(32)7-5-19-6-9-24(33)31(19)10-11-37-27-30-22(15-38-27)26(34)35/h1-5,7-8,12,14-15,19-20,32H,6,9-11,13H2,(H,34,35)/b7-5+/t19-,20+/m0/s1
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n/an/an/an/a 4.90n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Rattus norvegicus)		BDBM50385130
PNG
(CHEMBL2036320)
Show SMILES Cc1ccc(c(C)c1)-c1cccc(C[C@H](O)\C=C\[C@H]2CCC(=O)N2CCSc2nc(cs2)C(O)=O)c1 |r|
Show InChI InChI=1S/C28H30N2O4S2/c1-18-6-10-24(19(2)14-18)21-5-3-4-20(15-21)16-23(31)9-7-22-8-11-26(32)30(22)12-13-35-28-29-25(17-36-28)27(33)34/h3-7,9-10,14-15,17,22-23,31H,8,11-13,16H2,1-2H3,(H,33,34)/b9-7+/t22-,23+/m0/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Rattus norvegicus)		BDBM50385141
PNG
(CHEMBL2036321)
Show SMILES Cc1ccc(cc1C)-c1cccc(C[C@H](O)\C=C\[C@H]2CCC(=O)N2CCSc2nc(cs2)C(O)=O)c1 |r|
Show InChI InChI=1S/C28H30N2O4S2/c1-18-6-7-22(14-19(18)2)21-5-3-4-20(15-21)16-24(31)10-8-23-9-11-26(32)30(23)12-13-35-28-29-25(17-36-28)27(33)34/h3-8,10,14-15,17,23-24,31H,9,11-13,16H2,1-2H3,(H,33,34)/b10-8+/t23-,24+/m0/s1
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n/an/an/an/a 1.40E+3n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Rattus norvegicus)		BDBM50385132
PNG
(CHEMBL2036323)
Show SMILES O[C@@H](Cc1cccc(c1)-c1nc2ccccc2o1)\C=C\[C@H]1CCC(=O)N1CCSc1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C27H25N3O5S2/c31-20(15-17-4-3-5-18(14-17)25-28-21-6-1-2-7-23(21)35-25)10-8-19-9-11-24(32)30(19)12-13-36-27-29-22(16-37-27)26(33)34/h1-8,10,14,16,19-20,31H,9,11-13,15H2,(H,33,34)/b10-8+/t19-,20+/m0/s1
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n/an/an/an/a 1.60E+3n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Rattus norvegicus)		BDBM50360621
PNG
(CHEMBL1933717)
Show SMILES Cc1cccc(C[C@H](O)\C=C\[C@H]2CCC(=O)N2CCSCCCC(O)=O)c1 |r|
Show InChI InChI=1S/C21H29NO4S/c1-16-4-2-5-17(14-16)15-19(23)9-7-18-8-10-20(24)22(18)11-13-27-12-3-6-21(25)26/h2,4-5,7,9,14,18-19,23H,3,6,8,10-13,15H2,1H3,(H,25,26)/b9-7+/t18-,19+/m0/s1
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n/an/an/an/a 5.70n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Rattus norvegicus)		BDBM50385119
PNG
(CHEMBL2036309)
Show SMILES O[C@@H](Cc1cccc(c1)-c1ccccn1)\C=C\[C@H]1CCC(=O)N1CCSCCCC(O)=O |r|
Show InChI InChI=1S/C25H30N2O4S/c28-22(18-19-5-3-6-20(17-19)23-7-1-2-13-26-23)11-9-21-10-12-24(29)27(21)14-16-32-15-4-8-25(30)31/h1-3,5-7,9,11,13,17,21-22,28H,4,8,10,12,14-16,18H2,(H,30,31)/b11-9+/t21-,22+/m0/s1
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n/an/an/an/a 86n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Rattus norvegicus)		BDBM50385122
PNG
(CHEMBL2036312)
Show SMILES O[C@@H](Cc1cccc(c1)-c1nc2ccccc2o1)\C=C\[C@H]1CCC(=O)N1CCSCCCC(O)=O |r|
Show InChI InChI=1S/C27H30N2O5S/c30-22(12-10-21-11-13-25(31)29(21)14-16-35-15-4-9-26(32)33)18-19-5-3-6-20(17-19)27-28-23-7-1-2-8-24(23)34-27/h1-3,5-8,10,12,17,21-22,30H,4,9,11,13-16,18H2,(H,32,33)/b12-10+/t21-,22+/m0/s1
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n/an/an/an/a 13n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Rattus norvegicus)		BDBM50385123
PNG
(CHEMBL2036313)
Show SMILES O[C@@H](Cc1cccc(c1)-c1nc2ccccc2s1)\C=C\[C@H]1CCC(=O)N1CCSCCCC(O)=O |r|
Show InChI InChI=1S/C27H30N2O4S2/c30-22(12-10-21-11-13-25(31)29(21)14-16-34-15-4-9-26(32)33)18-19-5-3-6-20(17-19)27-28-23-7-1-2-8-24(23)35-27/h1-3,5-8,10,12,17,21-22,30H,4,9,11,13-16,18H2,(H,32,33)/b12-10+/t21-,22+/m0/s1
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n/an/an/an/a 3.20n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Rattus norvegicus)		BDBM50385129
PNG
(CHEMBL2036319)
Show SMILES COc1ccc(cc1)-c1cccc(C[C@H](O)\C=C\[C@H]2CCC(=O)N2CCSc2nc(cs2)C(O)=O)c1 |r|
Show InChI InChI=1S/C27H28N2O5S2/c1-34-23-10-5-19(6-11-23)20-4-2-3-18(15-20)16-22(30)9-7-21-8-12-25(31)29(21)13-14-35-27-28-24(17-36-27)26(32)33/h2-7,9-11,15,17,21-22,30H,8,12-14,16H2,1H3,(H,32,33)/b9-7+/t21-,22+/m0/s1
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n/an/an/an/a 15n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Rattus norvegicus)		BDBM50385138
PNG
(CHEMBL2037291)
Show SMILES Cc1cc(C)c2oc(nc2c1)-c1cccc(C[C@H](O)\C=C\[C@H]2CCC(=O)N2CCSc2nc(cs2)C(O)=O)c1 |r|
Show InChI InChI=1S/C29H29N3O5S2/c1-17-12-18(2)26-23(13-17)30-27(37-26)20-5-3-4-19(14-20)15-22(33)8-6-21-7-9-25(34)32(21)10-11-38-29-31-24(16-39-29)28(35)36/h3-6,8,12-14,16,21-22,33H,7,9-11,15H2,1-2H3,(H,35,36)/b8-6+/t21-,22+/m0/s1
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n/an/an/an/a 7.70n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Rattus norvegicus)		BDBM50385121
PNG
(CHEMBL2036311)
Show SMILES O[C@@H](Cc1cccc(c1)-c1ccc2[nH]ccc2c1)\C=C\[C@H]1CCC(=O)N1CCSCCCC(O)=O |r|
Show InChI InChI=1S/C28H32N2O4S/c31-25(9-7-24-8-11-27(32)30(24)14-16-35-15-2-5-28(33)34)18-20-3-1-4-21(17-20)22-6-10-26-23(19-22)12-13-29-26/h1,3-4,6-7,9-10,12-13,17,19,24-25,29,31H,2,5,8,11,14-16,18H2,(H,33,34)/b9-7+/t24-,25+/m0/s1
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n/an/an/an/a 85n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Rattus norvegicus)		BDBM50385130
PNG
(CHEMBL2036320)
Show SMILES Cc1ccc(c(C)c1)-c1cccc(C[C@H](O)\C=C\[C@H]2CCC(=O)N2CCSc2nc(cs2)C(O)=O)c1 |r|
Show InChI InChI=1S/C28H30N2O4S2/c1-18-6-10-24(19(2)14-18)21-5-3-4-20(15-21)16-23(31)9-7-22-8-11-26(32)30(22)12-13-35-28-29-25(17-36-28)27(33)34/h3-7,9-10,14-15,17,22-23,31H,8,11-13,16H2,1-2H3,(H,33,34)/b9-7+/t22-,23+/m0/s1
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n/an/an/an/a 160n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Rattus norvegicus)		BDBM50385133
PNG
(CHEMBL2036324)
Show SMILES O[C@@H](Cc1cccc(c1)-c1nc2ccccc2s1)\C=C\[C@H]1CCC(=O)N1CCSc1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C27H25N3O4S3/c31-20(15-17-4-3-5-18(14-17)25-28-21-6-1-2-7-23(21)37-25)10-8-19-9-11-24(32)30(19)12-13-35-27-29-22(16-36-27)26(33)34/h1-8,10,14,16,19-20,31H,9,11-13,15H2,(H,33,34)/b10-8+/t19-,20+/m0/s1
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n/an/an/an/a 13n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Rattus norvegicus)		BDBM50366137
PNG
(CHEMBL1957436)
Show SMILES O[C@@H](Cc1cccc(c1)-c1ccc(Cl)cc1)\C=C\[C@H]1CCC(=O)N1CCSc1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C26H25ClN2O4S2/c27-20-6-4-18(5-7-20)19-3-1-2-17(14-19)15-22(30)10-8-21-9-11-24(31)29(21)12-13-34-26-28-23(16-35-26)25(32)33/h1-8,10,14,16,21-22,30H,9,11-13,15H2,(H,32,33)/b10-8+/t21-,22+/m0/s1
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n/an/an/an/a 260n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Rattus norvegicus)		BDBM50385118
PNG
(CHEMBL2036308)
Show SMILES O[C@@H](Cc1cccc(c1)-c1ccc2ccccc2c1)\C=C\[C@H]1CCC(=O)N1CCSCCCC(O)=O |r|
Show InChI InChI=1S/C30H33NO4S/c32-28(14-12-27-13-15-29(33)31(27)16-18-36-17-4-9-30(34)35)20-22-5-3-8-24(19-22)26-11-10-23-6-1-2-7-25(23)21-26/h1-3,5-8,10-12,14,19,21,27-28,32H,4,9,13,15-18,20H2,(H,34,35)/b14-12+/t27-,28+/m0/s1
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n/an/an/an/a 96n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Rattus norvegicus)		BDBM50385120
PNG
(CHEMBL2036310)
Show SMILES O[C@@H](Cc1cccc(c1)N1Cc2ccccc2C1)\C=C\[C@H]1CCC(=O)N1CCSCCCC(O)=O |r|
Show InChI InChI=1S/C28H34N2O4S/c31-26(12-10-24-11-13-27(32)30(24)14-16-35-15-4-9-28(33)34)18-21-5-3-8-25(17-21)29-19-22-6-1-2-7-23(22)20-29/h1-3,5-8,10,12,17,24,26,31H,4,9,11,13-16,18-20H2,(H,33,34)/b12-10+/t24-,26+/m0/s1
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n/an/an/an/a 28n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Rattus norvegicus)		BDBM50366137
PNG
(CHEMBL1957436)
Show SMILES O[C@@H](Cc1cccc(c1)-c1ccc(Cl)cc1)\C=C\[C@H]1CCC(=O)N1CCSc1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C26H25ClN2O4S2/c27-20-6-4-18(5-7-20)19-3-1-2-17(14-19)15-22(30)10-8-21-9-11-24(31)29(21)12-13-34-26-28-23(16-35-26)25(32)33/h1-8,10,14,16,21-22,30H,9,11-13,15H2,(H,32,33)/b10-8+/t21-,22+/m0/s1
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n/an/an/an/a 27n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Rattus norvegicus)		BDBM50385141
PNG
(CHEMBL2036321)
Show SMILES Cc1ccc(cc1C)-c1cccc(C[C@H](O)\C=C\[C@H]2CCC(=O)N2CCSc2nc(cs2)C(O)=O)c1 |r|
Show InChI InChI=1S/C28H30N2O4S2/c1-18-6-7-22(14-19(18)2)21-5-3-4-20(15-21)16-24(31)10-8-23-9-11-26(32)30(23)12-13-35-28-29-25(17-36-28)27(33)34/h3-8,10,14-15,17,23-24,31H,9,11-13,16H2,1-2H3,(H,33,34)/b10-8+/t23-,24+/m0/s1
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n/an/an/an/a 21n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Rattus norvegicus)		BDBM50385132
PNG
(CHEMBL2036323)
Show SMILES O[C@@H](Cc1cccc(c1)-c1nc2ccccc2o1)\C=C\[C@H]1CCC(=O)N1CCSc1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C27H25N3O5S2/c31-20(15-17-4-3-5-18(14-17)25-28-21-6-1-2-7-23(21)35-25)10-8-19-9-11-24(32)30(19)12-13-36-27-29-22(16-37-27)26(33)34/h1-8,10,14,16,19-20,31H,9,11-13,15H2,(H,33,34)/b10-8+/t19-,20+/m0/s1
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n/an/an/an/a 2.20n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Rattus norvegicus)		BDBM50385125
PNG
(CHEMBL2036315)
Show SMILES O[C@@H](Cc1cccc(OCc2cccnc2)c1)\C=C\[C@H]1CCC(=O)N1CCSCCCC(O)=O |r|
Show InChI InChI=1S/C26H32N2O5S/c29-23(16-20-4-1-6-24(17-20)33-19-21-5-2-12-27-18-21)10-8-22-9-11-25(30)28(22)13-15-34-14-3-7-26(31)32/h1-2,4-6,8,10,12,17-18,22-23,29H,3,7,9,11,13-16,19H2,(H,31,32)/b10-8+/t22-,23+/m0/s1
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n/an/an/an/a 19n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Rattus norvegicus)		BDBM50385128
PNG
(CHEMBL2036318)
Show SMILES Cc1ccc(cc1)-c1cccc(C[C@H](O)\C=C\[C@H]2CCC(=O)N2CCSc2nc(cs2)C(O)=O)c1 |r|
Show InChI InChI=1S/C27H28N2O4S2/c1-18-5-7-20(8-6-18)21-4-2-3-19(15-21)16-23(30)11-9-22-10-12-25(31)29(22)13-14-34-27-28-24(17-35-27)26(32)33/h2-9,11,15,17,22-23,30H,10,12-14,16H2,1H3,(H,32,33)/b11-9+/t22-,23+/m0/s1
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n/an/an/an/a 380n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Rattus norvegicus)		BDBM50385129
PNG
(CHEMBL2036319)
Show SMILES COc1ccc(cc1)-c1cccc(C[C@H](O)\C=C\[C@H]2CCC(=O)N2CCSc2nc(cs2)C(O)=O)c1 |r|
Show InChI InChI=1S/C27H28N2O5S2/c1-34-23-10-5-19(6-11-23)20-4-2-3-18(15-20)16-22(30)9-7-21-8-12-25(31)29(21)13-14-35-27-28-24(17-36-27)26(32)33/h2-7,9-11,15,17,21-22,30H,8,12-14,16H2,1H3,(H,32,33)/b9-7+/t21-,22+/m0/s1
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n/an/an/an/a 4.60E+3n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Rattus norvegicus)		BDBM50385137
PNG
(CHEMBL2037290)
Show SMILES Cc1cccc2oc(nc12)-c1cccc(C[C@H](O)\C=C\[C@H]2CCC(=O)N2CCSc2nc(cs2)C(O)=O)c1 |r|
Show InChI InChI=1S/C28H27N3O5S2/c1-17-4-2-7-23-25(17)30-26(36-23)19-6-3-5-18(14-19)15-21(32)10-8-20-9-11-24(33)31(20)12-13-37-28-29-22(16-38-28)27(34)35/h2-8,10,14,16,20-21,32H,9,11-13,15H2,1H3,(H,34,35)/b10-8+/t20-,21+/m0/s1
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n/an/an/an/a 8.50E+3n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Rattus norvegicus)		BDBM50385140
PNG
(CHEMBL2036307)
Show SMILES O[C@@H](Cc1cccc(c1)-c1ccccc1)\C=C\[C@H]1CCC(=O)N1CCSCCCC(O)=O |r|
Show InChI InChI=1S/C26H31NO4S/c28-24(19-20-6-4-9-22(18-20)21-7-2-1-3-8-21)13-11-23-12-14-25(29)27(23)15-17-32-16-5-10-26(30)31/h1-4,6-9,11,13,18,23-24,28H,5,10,12,14-17,19H2,(H,30,31)/b13-11+/t23-,24+/m0/s1
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n/an/an/an/a 52n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Rattus norvegicus)		BDBM50385127
PNG
(CHEMBL2036317)
Show SMILES O[C@@H](Cc1cccc(OCc2ccncc2)c1)\C=C\[C@H]1CCC(=O)N1CCSCCCC(O)=O |r|
Show InChI InChI=1S/C26H32N2O5S/c29-23(17-21-3-1-4-24(18-21)33-19-20-10-12-27-13-11-20)8-6-22-7-9-25(30)28(22)14-16-34-15-2-5-26(31)32/h1,3-4,6,8,10-13,18,22-23,29H,2,5,7,9,14-17,19H2,(H,31,32)/b8-6+/t22-,23+/m0/s1
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n/an/an/an/a 46n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Rattus norvegicus)		BDBM50366136
PNG
(CHEMBL1957435)
Show SMILES O[C@@H](Cc1cccc(c1)-c1ccccc1)\C=C\[C@H]1CCC(=O)N1CCSc1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C26H26N2O4S2/c29-22(16-18-5-4-8-20(15-18)19-6-2-1-3-7-19)11-9-21-10-12-24(30)28(21)13-14-33-26-27-23(17-34-26)25(31)32/h1-9,11,15,17,21-22,29H,10,12-14,16H2,(H,31,32)/b11-9+/t21-,22+/m0/s1
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n/an/an/an/a 8n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Rattus norvegicus)		BDBM50385135
PNG
(CHEMBL2036326)
Show SMILES Cc1ccc2oc(nc2c1)-c1cccc(C[C@H](O)\C=C\[C@H]2CCC(=O)N2CCSc2nc(cs2)C(O)=O)c1 |r|
Show InChI InChI=1S/C28H27N3O5S2/c1-17-5-9-24-22(13-17)29-26(36-24)19-4-2-3-18(14-19)15-21(32)8-6-20-7-10-25(33)31(20)11-12-37-28-30-23(16-38-28)27(34)35/h2-6,8-9,13-14,16,20-21,32H,7,10-12,15H2,1H3,(H,34,35)/b8-6+/t20-,21+/m0/s1
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n/an/an/an/a 8.80n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Rattus norvegicus)		BDBM50385131
PNG
(CHEMBL2036322)
Show SMILES O[C@@H](Cc1cccc(c1)-c1cc2ccccc2o1)\C=C\[C@H]1CCC(=O)N1CCSc1nc(cs1)C(O)=O |r|
Show InChI InChI=1S/C28H26N2O5S2/c31-22(15-18-4-3-6-19(14-18)25-16-20-5-1-2-7-24(20)35-25)10-8-21-9-11-26(32)30(21)12-13-36-28-29-23(17-37-28)27(33)34/h1-8,10,14,16-17,21-22,31H,9,11-13,15H2,(H,33,34)/b10-8+/t21-,22+/m0/s1
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n/an/an/an/a 1.50E+3n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay

Bioorg Med Chem 20: 3502-22 (2012)


Article DOI: 10.1016/j.bmc.2012.04.008
BindingDB Entry DOI: 10.7270/Q2D50P0B
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%