Affinity Data by PubMed id=22559926

PubMed code 22559926

Found 6 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50388620 (CHEMBL2058538) Show SMILES CC(C)n1nc(C#Cc2ccccc2)c2c(N)ncnc12 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
University of Gothenburg Curated by ChEMBL					Assay Description Inhibition of RET by commercial radiometric assay				J Med Chem 55: 4872-6 (2012) Article DOI: 10.1021/jm3003944 BindingDB Entry DOI: 10.7270/Q2NK3G3N
University of Gothenburg Curated by ChEMBL					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50388621 (CHEMBL2058539) Show SMILES CC(C)n1nc(C#Cc2ccc(F)cc2)c2c(N)ncnc12 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	43	n/a	n/a	n/a	n/a	n/a	n/a
University of Gothenburg Curated by ChEMBL					Assay Description Inhibition of RET by commercial radiometric assay				J Med Chem 55: 4872-6 (2012) Article DOI: 10.1021/jm3003944 BindingDB Entry DOI: 10.7270/Q2NK3G3N
University of Gothenburg Curated by ChEMBL					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50388624 (CHEMBL2058543) Show SMILES CC(C)n1nc(\C=C\c2ccccc2)c2c(N)ncnc12 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
University of Gothenburg Curated by ChEMBL					Assay Description Inhibition of RET by commercial radiometric assay				J Med Chem 55: 4872-6 (2012) Article DOI: 10.1021/jm3003944 BindingDB Entry DOI: 10.7270/Q2NK3G3N
University of Gothenburg Curated by ChEMBL					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50388625 (CHEMBL2058542) Show SMILES CC(C)n1nc(C#Cc2cc(C)ccc2C)c2c(N)ncnc12 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	83	n/a	n/a	n/a	n/a	n/a	n/a
University of Gothenburg Curated by ChEMBL					Assay Description Inhibition of RET by commercial radiometric assay				J Med Chem 55: 4872-6 (2012) Article DOI: 10.1021/jm3003944 BindingDB Entry DOI: 10.7270/Q2NK3G3N
University of Gothenburg Curated by ChEMBL					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50388622 (CHEMBL2058540) Show SMILES CC(C)n1nc(C#Cc2cccc(N)c2)c2c(N)ncnc12 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
University of Gothenburg Curated by ChEMBL					Assay Description Inhibition of RET by commercial radiometric assay				J Med Chem 55: 4872-6 (2012) Article DOI: 10.1021/jm3003944 BindingDB Entry DOI: 10.7270/Q2NK3G3N
University of Gothenburg Curated by ChEMBL					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50388623 (CHEMBL2058541) Show SMILES CC(C)n1nc(C#Cc2ccccc2N)c2c(N)ncnc12 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	195	n/a	n/a	n/a	n/a	n/a	n/a
University of Gothenburg Curated by ChEMBL					Assay Description Inhibition of RET by commercial radiometric assay				J Med Chem 55: 4872-6 (2012) Article DOI: 10.1021/jm3003944 BindingDB Entry DOI: 10.7270/Q2NK3G3N
University of Gothenburg Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%