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PubMed code 22579487

Compile data set for download or QSAR
Found 53 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384024
PNG
(CHEMBL2032280 | CHEMBL2079349)
Show SMILES Cc1c(O)ccc2nc(oc12)-c1cc(cnc1N)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C21H22N6O2/c1-12-18(28)3-2-17-19(12)29-21(26-17)16-8-13(9-24-20(16)22)14-10-25-27(11-14)15-4-6-23-7-5-15/h2-3,8-11,15,23,28H,4-7H2,1H3,(H2,22,24)
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n/an/a 0.200n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met by time resolved-fluorescence resonance energy transfer analysis


Bioorg Med Chem Lett 22: 4044-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.083
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50384038
PNG
(CHEMBL2032155)
Show SMILES Nc1ncc(cc1-c1nc2cccc(-c3ccccn3)c2o1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C25H23N7O/c26-24-20(12-16(13-29-24)17-14-30-32(15-17)18-7-10-27-11-8-18)25-31-22-6-3-4-19(23(22)33-25)21-5-1-2-9-28-21/h1-6,9,12-15,18,27H,7-8,10-11H2,(H2,26,29)
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n/an/a 0.600n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant FLT3 by time resolved-fluorescence resonance energy transfer analysis


Bioorg Med Chem Lett 22: 4044-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.083
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384038
PNG
(CHEMBL2032155)
Show SMILES Nc1ncc(cc1-c1nc2cccc(-c3ccccn3)c2o1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C25H23N7O/c26-24-20(12-16(13-29-24)17-14-30-32(15-17)18-7-10-27-11-8-18)25-31-22-6-3-4-19(23(22)33-25)21-5-1-2-9-28-21/h1-6,9,12-15,18,27H,7-8,10-11H2,(H2,26,29)
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n/an/a 1.60n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met by time resolved-fluorescence resonance energy transfer analysis


Bioorg Med Chem Lett 22: 4044-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.083
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50384004
PNG
(CHEMBL2032276)
Show SMILES Cc1cc2oc(nc2cc1O)-c1cc(cnc1N)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C21H22N6O2/c1-12-6-19-17(8-18(12)28)26-21(29-19)16-7-13(9-24-20(16)22)14-10-25-27(11-14)15-2-4-23-5-3-15/h6-11,15,23,28H,2-5H2,1H3,(H2,22,24)
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n/an/a 2n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant FLT3 by time resolved-fluorescence resonance energy transfer analysis


Bioorg Med Chem Lett 22: 4044-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.083
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384027
PNG
(CHEMBL2032277)
Show SMILES Cc1cc2oc(nc2c(C)c1O)-c1cc(cnc1N)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C22H24N6O2/c1-12-7-18-19(13(2)20(12)29)27-22(30-18)17-8-14(9-25-21(17)23)15-10-26-28(11-15)16-3-5-24-6-4-16/h7-11,16,24,29H,3-6H2,1-2H3,(H2,23,25)
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n/an/a 3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met by time resolved-fluorescence resonance energy transfer analysis


Bioorg Med Chem Lett 22: 4044-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.083
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50384019
PNG
(CHEMBL2032285 | CHEMBL2079397)
Show SMILES Nc1ccc2nc(oc2c1)-c1cc(cnc1N)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C20H21N7O/c21-14-1-2-17-18(8-14)28-20(26-17)16-7-12(9-24-19(16)22)13-10-25-27(11-13)15-3-5-23-6-4-15/h1-2,7-11,15,23H,3-6,21H2,(H2,22,24)
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n/an/a 3.60n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant FLT3 by time resolved-fluorescence resonance energy transfer analysis


Bioorg Med Chem Lett 22: 4044-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.083
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50384026
PNG
(CHEMBL2032278)
Show SMILES CCc1cc2oc(nc2cc1O)-c1cc(cnc1N)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C22H24N6O2/c1-2-13-8-20-18(9-19(13)29)27-22(30-20)17-7-14(10-25-21(17)23)15-11-26-28(12-15)16-3-5-24-6-4-16/h7-12,16,24,29H,2-6H2,1H3,(H2,23,25)
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n/an/a 4n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant FLT3 by time resolved-fluorescence resonance energy transfer analysis


Bioorg Med Chem Lett 22: 4044-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.083
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384023
PNG
(CHEMBL2032281)
Show SMILES Nc1ncc(cc1-c1nc2ccc(O)c(-c3cccnc3)c2o1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C25H23N7O2/c26-24-19(10-16(12-29-24)17-13-30-32(14-17)18-5-8-27-9-6-18)25-31-20-3-4-21(33)22(23(20)34-25)15-2-1-7-28-11-15/h1-4,7,10-14,18,27,33H,5-6,8-9H2,(H2,26,29)
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n/an/a 4n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met by time resolved-fluorescence resonance energy transfer analysis


Bioorg Med Chem Lett 22: 4044-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.083
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50384006
PNG
(CHEMBL2032274)
Show SMILES Nc1ncc(cc1-c1nc2ccc(O)cc2o1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C20H20N6O2/c21-19-16(20-25-17-2-1-15(27)8-18(17)28-20)7-12(9-23-19)13-10-24-26(11-13)14-3-5-22-6-4-14/h1-2,7-11,14,22,27H,3-6H2,(H2,21,23)
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n/an/a 4n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant FLT3 by time resolved-fluorescence resonance energy transfer analysis


Bioorg Med Chem Lett 22: 4044-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.083
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384022
PNG
(CHEMBL2032282)
Show SMILES Nc1ncc(cc1-c1nc2ccc(O)c(-c3cnccn3)c2o1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C24H22N8O2/c25-23-17(9-14(10-29-23)15-11-30-32(13-15)16-3-5-26-6-4-16)24-31-18-1-2-20(33)21(22(18)34-24)19-12-27-7-8-28-19/h1-2,7-13,16,26,33H,3-6H2,(H2,25,29)
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n/an/a 8n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met by time resolved-fluorescence resonance energy transfer analysis


Bioorg Med Chem Lett 22: 4044-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.083
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384026
PNG
(CHEMBL2032278)
Show SMILES CCc1cc2oc(nc2cc1O)-c1cc(cnc1N)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C22H24N6O2/c1-2-13-8-20-18(9-19(13)29)27-22(30-20)17-7-14(10-25-21(17)23)15-11-26-28(12-15)16-3-5-24-6-4-16/h7-12,16,24,29H,2-6H2,1H3,(H2,23,25)
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n/an/a 9n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met by time resolved-fluorescence resonance energy transfer analysis


Bioorg Med Chem Lett 22: 4044-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.083
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384019
PNG
(CHEMBL2032285 | CHEMBL2079397)
Show SMILES Nc1ccc2nc(oc2c1)-c1cc(cnc1N)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C20H21N7O/c21-14-1-2-17-18(8-14)28-20(26-17)16-7-12(9-24-19(16)22)13-10-25-27(11-13)15-3-5-23-6-4-15/h1-2,7-11,15,23H,3-6,21H2,(H2,22,24)
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n/an/a 14n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met by time resolved-fluorescence resonance energy transfer analysis


Bioorg Med Chem Lett 22: 4044-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.083
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384045
PNG
(CHEMBL2032298)
Show SMILES Cn1cc(cn1)-c1cnc(N)c(c1)-c1nc2cccc(-c3ccccn3)c2o1
Show InChI InChI=1S/C21H16N6O/c1-27-12-14(11-25-27)13-9-16(20(22)24-10-13)21-26-18-7-4-5-15(19(18)28-21)17-6-2-3-8-23-17/h2-12H,1H3,(H2,22,24)
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n/an/a 14n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met by time resolved-fluorescence resonance energy transfer analysis


Bioorg Med Chem Lett 22: 4044-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.083
More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM50384006
PNG
(CHEMBL2032274)
Show SMILES Nc1ncc(cc1-c1nc2ccc(O)cc2o1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C20H20N6O2/c21-19-16(20-25-17-2-1-15(27)8-18(17)28-20)7-12(9-23-19)13-10-24-26(11-13)14-3-5-22-6-4-14/h1-2,7-11,14,22,27H,3-6H2,(H2,21,23)
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n/an/a 14n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of Ron


Bioorg Med Chem Lett 22: 4044-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.083
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50384021
PNG
(CHEMBL2032283 | CHEMBL2079205)
Show SMILES Nc1ncc(cc1-c1nc2ccc(O)c(-c3ccccc3)c2o1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C26H24N6O2/c27-25-20(12-17(13-29-25)18-14-30-32(15-18)19-8-10-28-11-9-19)26-31-21-6-7-22(33)23(24(21)34-26)16-4-2-1-3-5-16/h1-7,12-15,19,28,33H,8-11H2,(H2,27,29)
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n/an/a 14n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant FLT3 by time resolved-fluorescence resonance energy transfer analysis


Bioorg Med Chem Lett 22: 4044-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.083
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384006
PNG
(CHEMBL2032274)
Show SMILES Nc1ncc(cc1-c1nc2ccc(O)cc2o1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C20H20N6O2/c21-19-16(20-25-17-2-1-15(27)8-18(17)28-20)7-12(9-23-19)13-10-24-26(11-13)14-3-5-22-6-4-14/h1-2,7-11,14,22,27H,3-6H2,(H2,21,23)
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n/an/a 19n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met by time resolved-fluorescence resonance energy transfer analysis


Bioorg Med Chem Lett 22: 4044-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.083
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384029
PNG
(CHEMBL2032273)
Show SMILES Nc1ncc(cc1-c1nc2cc(O)ccc2o1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C20H20N6O2/c21-19-16(20-25-17-8-15(27)1-2-18(17)28-20)7-12(9-23-19)13-10-24-26(11-13)14-3-5-22-6-4-14/h1-2,7-11,14,22,27H,3-6H2,(H2,21,23)
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n/an/a 22n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met by time resolved-fluorescence resonance energy transfer analysis


Bioorg Med Chem Lett 22: 4044-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.083
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384030
PNG
(CHEMBL2032272 | CHEMBL2079392)
Show SMILES Nc1ncc(cc1-c1nc2ccc(Oc3ncccn3)cc2o1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C24H22N8O2/c25-22-19(10-15(12-29-22)16-13-30-32(14-16)17-4-8-26-9-5-17)23-31-20-3-2-18(11-21(20)34-23)33-24-27-6-1-7-28-24/h1-3,6-7,10-14,17,26H,4-5,8-9H2,(H2,25,29)
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n/an/a 23n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met by time resolved-fluorescence resonance energy transfer analysis


Bioorg Med Chem Lett 22: 4044-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.083
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384004
PNG
(CHEMBL2032276)
Show SMILES Cc1cc2oc(nc2cc1O)-c1cc(cnc1N)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C21H22N6O2/c1-12-6-19-17(8-18(12)28)26-21(29-19)16-7-13(9-24-20(16)22)14-10-25-27(11-14)15-2-4-23-5-3-15/h6-11,15,23,28H,2-5H2,1H3,(H2,22,24)
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n/an/a 27n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met by time resolved-fluorescence resonance energy transfer analysis


Bioorg Med Chem Lett 22: 4044-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.083
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384008
PNG
(CHEMBL2032296)
Show SMILES CC(=O)N1CCC(CC1)n1cc(cn1)-c1cnc(N)c(c1)-c1nc2c(C)c(O)c(C)cc2o1
Show InChI InChI=1S/C24H26N6O3/c1-13-8-20-21(14(2)22(13)32)28-24(33-20)19-9-16(10-26-23(19)25)17-11-27-30(12-17)18-4-6-29(7-5-18)15(3)31/h8-12,18,32H,4-7H2,1-3H3,(H2,25,26)
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n/an/a 28n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met by time resolved-fluorescence resonance energy transfer analysis


Bioorg Med Chem Lett 22: 4044-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.083
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384040
PNG
(CHEMBL2032153)
Show SMILES Nc1ncc(cc1-c1nc2ccc(cc2o1)-c1cccnc1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C25H23N7O/c26-24-21(10-18(13-29-24)19-14-30-32(15-19)20-5-8-27-9-6-20)25-31-22-4-3-16(11-23(22)33-25)17-2-1-7-28-12-17/h1-4,7,10-15,20,27H,5-6,8-9H2,(H2,26,29)
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n/an/a 28n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met by time resolved-fluorescence resonance energy transfer analysis


Bioorg Med Chem Lett 22: 4044-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.083
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50384024
PNG
(CHEMBL2032280 | CHEMBL2079349)
Show SMILES Cc1c(O)ccc2nc(oc12)-c1cc(cnc1N)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C21H22N6O2/c1-12-18(28)3-2-17-19(12)29-21(26-17)16-8-13(9-24-20(16)22)14-10-25-27(11-14)15-4-6-23-7-5-15/h2-3,8-11,15,23,28H,4-7H2,1H3,(H2,22,24)
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n/an/a 34n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant FLT3 by time resolved-fluorescence resonance energy transfer analysis


Bioorg Med Chem Lett 22: 4044-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.083
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384031
PNG
(CHEMBL2032162)
Show SMILES Nc1ncc(cc1-c1nc2ccc(Oc3ccncn3)cc2o1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C24H22N8O2/c25-23-19(9-15(11-28-23)16-12-30-32(13-16)17-3-6-26-7-4-17)24-31-20-2-1-18(10-21(20)34-24)33-22-5-8-27-14-29-22/h1-2,5,8-14,17,26H,3-4,6-7H2,(H2,25,28)
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n/an/a 34n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met by time resolved-fluorescence resonance energy transfer analysis


Bioorg Med Chem Lett 22: 4044-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.083
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50384022
PNG
(CHEMBL2032282)
Show SMILES Nc1ncc(cc1-c1nc2ccc(O)c(-c3cnccn3)c2o1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C24H22N8O2/c25-23-17(9-14(10-29-23)15-11-30-32(13-15)16-3-5-26-6-4-16)24-31-18-1-2-20(33)21(22(18)34-24)19-12-27-7-8-28-19/h1-2,7-13,16,26,33H,3-6H2,(H2,25,29)
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n/an/a 35n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant FLT3 by time resolved-fluorescence resonance energy transfer analysis


Bioorg Med Chem Lett 22: 4044-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.083
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384043
PNG
(CHEMBL2032150)
Show SMILES Nc1ncc(cc1-c1nc2cc(Cl)cc(F)c2o1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C20H18ClFN6O/c21-13-6-16(22)18-17(7-13)27-20(29-18)15-5-11(8-25-19(15)23)12-9-26-28(10-12)14-1-3-24-4-2-14/h5-10,14,24H,1-4H2,(H2,23,25)
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n/an/a 41n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met by time resolved-fluorescence resonance energy transfer analysis


Bioorg Med Chem Lett 22: 4044-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.083
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384014
PNG
(CHEMBL2032290)
Show SMILES Cc1ccc(cc1)S(=O)(=O)NC(=O)Nc1ccc2nc(oc2c1)-c1cc(cnc1N)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C28H28N8O4S/c1-17-2-5-22(6-3-17)41(38,39)35-28(37)33-20-4-7-24-25(13-20)40-27(34-24)23-12-18(14-31-26(23)29)19-15-32-36(16-19)21-8-10-30-11-9-21/h2-7,12-16,21,30H,8-11H2,1H3,(H2,29,31)(H2,33,35,37)
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n/an/a 45n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met by time resolved-fluorescence resonance energy transfer analysis


Bioorg Med Chem Lett 22: 4044-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.083
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384021
PNG
(CHEMBL2032283 | CHEMBL2079205)
Show SMILES Nc1ncc(cc1-c1nc2ccc(O)c(-c3ccccc3)c2o1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C26H24N6O2/c27-25-20(12-17(13-29-25)18-14-30-32(15-18)19-8-10-28-11-9-19)26-31-21-6-7-22(33)23(24(21)34-26)16-4-2-1-3-5-16/h1-7,12-15,19,28,33H,8-11H2,(H2,27,29)
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n/an/a 48n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met by time resolved-fluorescence resonance energy transfer analysis


Bioorg Med Chem Lett 22: 4044-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.083
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384009
PNG
(CHEMBL2032295)
Show SMILES CC(=O)N1CCC(CC1)n1cc(cn1)-c1cnc(N)c(c1)-c1nc2cc(O)c(C)cc2o1
Show InChI InChI=1S/C23H24N6O3/c1-13-7-21-19(9-20(13)31)27-23(32-21)18-8-15(10-25-22(18)24)16-11-26-29(12-16)17-3-5-28(6-4-17)14(2)30/h7-12,17,31H,3-6H2,1-2H3,(H2,24,25)
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n/an/a 51n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met by time resolved-fluorescence resonance energy transfer analysis


Bioorg Med Chem Lett 22: 4044-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.083
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384044
PNG
(CHEMBL2032149)
Show SMILES Nc1ncc(cc1-c1nc2cc(Cl)ccc2o1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C20H19ClN6O/c21-14-1-2-18-17(8-14)26-20(28-18)16-7-12(9-24-19(16)22)13-10-25-27(11-13)15-3-5-23-6-4-15/h1-2,7-11,15,23H,3-6H2,(H2,22,24)
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n/an/a 53n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met by time resolved-fluorescence resonance energy transfer analysis


Bioorg Med Chem Lett 22: 4044-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.083
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384007
PNG
(CHEMBL2032297)
Show SMILES Nc1ncc(cc1-c1nc2cccc(-c3ccccn3)c2o1)-c1cnn(CCO)c1
Show InChI InChI=1S/C22H18N6O2/c23-21-17(10-14(11-25-21)15-12-26-28(13-15)8-9-29)22-27-19-6-3-4-16(20(19)30-22)18-5-1-2-7-24-18/h1-7,10-13,29H,8-9H2,(H2,23,25)
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n/an/a 53n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met by time resolved-fluorescence resonance energy transfer analysis


Bioorg Med Chem Lett 22: 4044-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.083
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384020
PNG
(CHEMBL2032284 | CHEMBL2079522)
Show SMILES Nc1ccc2oc(nc2c1)-c1cc(cnc1N)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C20H21N7O/c21-14-1-2-18-17(8-14)26-20(28-18)16-7-12(9-24-19(16)22)13-10-25-27(11-13)15-3-5-23-6-4-15/h1-2,7-11,15,23H,3-6,21H2,(H2,22,24)
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n/an/a 56n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met by time resolved-fluorescence resonance energy transfer analysis


Bioorg Med Chem Lett 22: 4044-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.083
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384032
PNG
(CHEMBL2032161)
Show SMILES Nc1ncc(cc1-c1nc2ccc(Nc3ncccn3)cc2o1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C24H23N9O/c25-22-19(10-15(12-29-22)16-13-30-33(14-16)18-4-8-26-9-5-18)23-32-20-3-2-17(11-21(20)34-23)31-24-27-6-1-7-28-24/h1-3,6-7,10-14,18,26H,4-5,8-9H2,(H2,25,29)(H,27,28,31)
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n/an/a 63n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met by time resolved-fluorescence resonance energy transfer analysis


Bioorg Med Chem Lett 22: 4044-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.083
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384016
PNG
(CHEMBL2032288)
Show SMILES Nc1ncc(cc1-c1nc2ccc(NS(=O)(=O)c3ccc(F)cc3)cc2o1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C26H24FN7O3S/c27-18-1-4-21(5-2-18)38(35,36)33-19-3-6-23-24(12-19)37-26(32-23)22-11-16(13-30-25(22)28)17-14-31-34(15-17)20-7-9-29-10-8-20/h1-6,11-15,20,29,33H,7-10H2,(H2,28,30)
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n/an/a 67n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met by time resolved-fluorescence resonance energy transfer analysis


Bioorg Med Chem Lett 22: 4044-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.083
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384037
PNG
(CHEMBL2032156)
Show SMILES COc1ccc(cc1)-c1cccc2nc(oc12)-c1cc(cnc1N)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C27H26N6O2/c1-34-21-7-5-17(6-8-21)22-3-2-4-24-25(22)35-27(32-24)23-13-18(14-30-26(23)28)19-15-31-33(16-19)20-9-11-29-12-10-20/h2-8,13-16,20,29H,9-12H2,1H3,(H2,28,30)
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n/an/a 77n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met by time resolved-fluorescence resonance energy transfer analysis


Bioorg Med Chem Lett 22: 4044-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.083
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50321421
PNG
(3-(benzo[d]oxazol-2-yl)-5-(1-(piperidin-4-yl)-1H-p...)
Show SMILES Nc1ncc(cc1-c1nc2ccccc2o1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C20H20N6O/c21-19-16(20-25-17-3-1-2-4-18(17)27-20)9-13(10-23-19)14-11-24-26(12-14)15-5-7-22-8-6-15/h1-4,9-12,15,22H,5-8H2,(H2,21,23)
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n/an/a 80n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met by time resolved-fluorescence resonance energy transfer analysis


Bioorg Med Chem Lett 22: 4044-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.083
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384017
PNG
(CHEMBL2032287)
Show SMILES CS(=O)(=O)Nc1ccc2nc(oc2c1)-c1cc(cnc1N)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C21H23N7O3S/c1-32(29,30)27-15-2-3-18-19(9-15)31-21(26-18)17-8-13(10-24-20(17)22)14-11-25-28(12-14)16-4-6-23-7-5-16/h2-3,8-12,16,23,27H,4-7H2,1H3,(H2,22,24)
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n/an/a 88n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met by time resolved-fluorescence resonance energy transfer analysis


Bioorg Med Chem Lett 22: 4044-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.083
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384011
PNG
(CHEMBL2032293)
Show SMILES Nc1ncc(cc1-c1nc2ccc(F)cc2o1)-c1cnn(c1)C1CCN(CCO)CC1
Show InChI InChI=1S/C22H23FN6O2/c23-16-1-2-19-20(10-16)31-22(27-19)18-9-14(11-25-21(18)24)15-12-26-29(13-15)17-3-5-28(6-4-17)7-8-30/h1-2,9-13,17,30H,3-8H2,(H2,24,25)
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n/an/a 90n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met by time resolved-fluorescence resonance energy transfer analysis


Bioorg Med Chem Lett 22: 4044-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.083
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM50384006
PNG
(CHEMBL2032274)
Show SMILES Nc1ncc(cc1-c1nc2ccc(O)cc2o1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C20H20N6O2/c21-19-16(20-25-17-2-1-15(27)8-18(17)28-20)7-12(9-23-19)13-10-24-26(11-13)14-3-5-22-6-4-14/h1-2,7-11,14,22,27H,3-6H2,(H2,21,23)
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n/an/a 90n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of Aurora A


Bioorg Med Chem Lett 22: 4044-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.083
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384028
PNG
(CHEMBL2032275)
Show SMILES Nc1ncc(cc1-c1nc2cccc(O)c2o1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C20H20N6O2/c21-19-15(20-25-16-2-1-3-17(27)18(16)28-20)8-12(9-23-19)13-10-24-26(11-13)14-4-6-22-7-5-14/h1-3,8-11,14,22,27H,4-7H2,(H2,21,23)
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n/an/a 110n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met by time resolved-fluorescence resonance energy transfer analysis


Bioorg Med Chem Lett 22: 4044-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.083
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384036
PNG
(CHEMBL2032157)
Show SMILES CC(C)Nc1cccc2nc(oc12)-c1cc(cnc1N)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C23H27N7O/c1-14(2)28-19-4-3-5-20-21(19)31-23(29-20)18-10-15(11-26-22(18)24)16-12-27-30(13-16)17-6-8-25-9-7-17/h3-5,10-14,17,25,28H,6-9H2,1-2H3,(H2,24,26)
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n/an/a 130n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met by time resolved-fluorescence resonance energy transfer analysis


Bioorg Med Chem Lett 22: 4044-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.083
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384041
PNG
(CHEMBL2032152)
Show SMILES CC(O)c1ccc2nc(oc2c1)-c1cc(cnc1N)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C22H24N6O2/c1-13(29)14-2-3-19-20(9-14)30-22(27-19)18-8-15(10-25-21(18)23)16-11-26-28(12-16)17-4-6-24-7-5-17/h2-3,8-13,17,24,29H,4-7H2,1H3,(H2,23,25)
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n/an/a 130n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met by time resolved-fluorescence resonance energy transfer analysis


Bioorg Med Chem Lett 22: 4044-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.083
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384018
PNG
(CHEMBL2032286)
Show SMILES Nc1ncc(cc1-c1nc2ccc(NC(=O)Nc3ccccc3)cc2o1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C27H26N8O2/c28-25-22(12-17(14-30-25)18-15-31-35(16-18)21-8-10-29-11-9-21)26-34-23-7-6-20(13-24(23)37-26)33-27(36)32-19-4-2-1-3-5-19/h1-7,12-16,21,29H,8-11H2,(H2,28,30)(H2,32,33,36)
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n/an/a 130n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met by time resolved-fluorescence resonance energy transfer analysis


Bioorg Med Chem Lett 22: 4044-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.083
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384033
PNG
(CHEMBL2032160)
Show SMILES CCCNc1ccc2nc(oc2c1)-c1cc(cnc1N)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C23H27N7O/c1-2-7-26-17-3-4-20-21(11-17)31-23(29-20)19-10-15(12-27-22(19)24)16-13-28-30(14-16)18-5-8-25-9-6-18/h3-4,10-14,18,25-26H,2,5-9H2,1H3,(H2,24,27)
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n/an/a 150n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met by time resolved-fluorescence resonance energy transfer analysis


Bioorg Med Chem Lett 22: 4044-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.083
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384035
PNG
(CHEMBL2032158 | CHEMBL2078645)
Show SMILES CNc1ccc2oc(nc2c1)-c1cc(cnc1N)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C21H23N7O/c1-23-15-2-3-19-18(9-15)27-21(29-19)17-8-13(10-25-20(17)22)14-11-26-28(12-14)16-4-6-24-7-5-16/h2-3,8-12,16,23-24H,4-7H2,1H3,(H2,22,25)
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n/an/a 160n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met by time resolved-fluorescence resonance energy transfer analysis


Bioorg Med Chem Lett 22: 4044-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.083
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384025
PNG
(CHEMBL2032279 | CHEMBL2079395)
Show SMILES Cc1cc2nc(oc2cc1O)-c1cc(cnc1N)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C21H22N6O2/c1-12-6-17-19(8-18(12)28)29-21(26-17)16-7-13(9-24-20(16)22)14-10-25-27(11-14)15-2-4-23-5-3-15/h6-11,15,23,28H,2-5H2,1H3,(H2,22,24)
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n/an/a 180n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met by time resolved-fluorescence resonance energy transfer analysis


Bioorg Med Chem Lett 22: 4044-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.083
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384039
PNG
(CHEMBL2032154)
Show SMILES Nc1ncc(cc1-c1nc2ccc(cc2o1)-c1cc[nH]n1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C23H22N8O/c24-22-18(23-29-20-2-1-14(10-21(20)32-23)19-5-8-27-30-19)9-15(11-26-22)16-12-28-31(13-16)17-3-6-25-7-4-17/h1-2,5,8-13,17,25H,3-4,6-7H2,(H2,24,26)(H,27,30)
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n/an/a 210n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met by time resolved-fluorescence resonance energy transfer analysis


Bioorg Med Chem Lett 22: 4044-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.083
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384010
PNG
(CHEMBL2032294)
Show SMILES CC(=O)N1CCC(CC1)n1cc(cn1)-c1cnc(N)c(c1)-c1nc2ccc(Cl)cc2o1
Show InChI InChI=1S/C22H21ClN6O2/c1-13(30)28-6-4-17(5-7-28)29-12-15(11-26-29)14-8-18(21(24)25-10-14)22-27-19-3-2-16(23)9-20(19)31-22/h2-3,8-12,17H,4-7H2,1H3,(H2,24,25)
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n/an/a 220n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met by time resolved-fluorescence resonance energy transfer analysis


Bioorg Med Chem Lett 22: 4044-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.083
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384012
PNG
(CHEMBL2032292)
Show SMILES CN1CCC(CC1)n1cc(cn1)-c1cnc(N)c(c1)-c1nc2ccc(F)cc2o1
Show InChI InChI=1S/C21H21FN6O/c1-27-6-4-16(5-7-27)28-12-14(11-25-28)13-8-17(20(23)24-10-13)21-26-18-3-2-15(22)9-19(18)29-21/h2-3,8-12,16H,4-7H2,1H3,(H2,23,24)
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n/an/a 240n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met by time resolved-fluorescence resonance energy transfer analysis


Bioorg Med Chem Lett 22: 4044-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.083
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384015
PNG
(CHEMBL2032289)
Show SMILES Nc1ncc(cc1-c1nc2ccc(Nc3ccc(F)cc3)cc2o1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C26H24FN7O/c27-18-1-3-19(4-2-18)32-20-5-6-23-24(12-20)35-26(33-23)22-11-16(13-30-25(22)28)17-14-31-34(15-17)21-7-9-29-10-8-21/h1-6,11-15,21,29,32H,7-10H2,(H2,28,30)
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n/an/a 410n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met by time resolved-fluorescence resonance energy transfer analysis


Bioorg Med Chem Lett 22: 4044-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.083
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384034
PNG
(CHEMBL2032159 | CHEMBL2032299)
Show SMILES CC(=O)Nc1ccc2oc(nc2c1)-c1cc(cnc1N)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C22H23N7O2/c1-13(30)27-16-2-3-20-19(9-16)28-22(31-20)18-8-14(10-25-21(18)23)15-11-26-29(12-15)17-4-6-24-7-5-17/h2-3,8-12,17,24H,4-7H2,1H3,(H2,23,25)(H,27,30)
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n/an/a 540n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met by time resolved-fluorescence resonance energy transfer analysis


Bioorg Med Chem Lett 22: 4044-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.083
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384034
PNG
(CHEMBL2032159 | CHEMBL2032299)
Show SMILES CC(=O)Nc1ccc2oc(nc2c1)-c1cc(cnc1N)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C22H23N7O2/c1-13(30)27-16-2-3-20-19(9-16)28-22(31-20)18-8-14(10-25-21(18)23)15-11-26-29(12-15)17-4-6-24-7-5-17/h2-3,8-12,17,24H,4-7H2,1H3,(H2,23,25)(H,27,30)
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n/an/a 540n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met by time resolved-fluorescence resonance energy transfer analysis


Bioorg Med Chem Lett 22: 4044-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.083
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384042
PNG
(CHEMBL2032151)
Show SMILES CC(=O)c1ccc2nc(oc2c1)-c1cc(cnc1N)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C22H22N6O2/c1-13(29)14-2-3-19-20(9-14)30-22(27-19)18-8-15(10-25-21(18)23)16-11-26-28(12-16)17-4-6-24-7-5-17/h2-3,8-12,17,24H,4-7H2,1H3,(H2,23,25)
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n/an/a 800n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met by time resolved-fluorescence resonance energy transfer analysis


Bioorg Med Chem Lett 22: 4044-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.083
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384013
PNG
(CHEMBL2032291)
Show SMILES Cn1cc(cn1)-c1cnc(N)c(c1)-c1nc2ccc(Cl)cc2o1
Show InChI InChI=1S/C16H12ClN5O/c1-22-8-10(7-20-22)9-4-12(15(18)19-6-9)16-21-13-3-2-11(17)5-14(13)23-16/h2-8H,1H3,(H2,18,19)
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n/an/a 1.70E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met by time resolved-fluorescence resonance energy transfer analysis


Bioorg Med Chem Lett 22: 4044-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.083
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%