Found 31 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50384120
(CHEMBL2029565)Show SMILES COc1cnc2ccc(cc2c1)[C@H](C)n1nnc2ccn(-c3cc(C)ns3)c(=O)c12 |r| Show InChI InChI=1S/C21H18N6O2S/c1-12-8-19(30-24-12)26-7-6-18-20(21(26)28)27(25-23-18)13(2)14-4-5-17-15(9-14)10-16(29-3)11-22-17/h4-11,13H,1-3H3/t13-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of c-Met |
Bioorg Med Chem Lett 22: 4089-93 (2012)
Article DOI: 10.1016/j.bmcl.2012.04.072
BindingDB Entry DOI: 10.7270/Q2J67HZ2 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50384118
(CHEMBL2029563)Show SMILES COCCOc1cnc2ccc(Cn3nnc4ccn(-c5cc(C)ns5)c(=O)c34)cc2c1 Show InChI InChI=1S/C22H20N6O3S/c1-14-9-20(32-25-14)27-6-5-19-21(22(27)29)28(26-24-19)13-15-3-4-18-16(10-15)11-17(12-23-18)31-8-7-30-2/h3-6,9-12H,7-8,13H2,1-2H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of c-Met |
Bioorg Med Chem Lett 22: 4089-93 (2012)
Article DOI: 10.1016/j.bmcl.2012.04.072
BindingDB Entry DOI: 10.7270/Q2J67HZ2 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50384121
(CHEMBL2029678)Show SMILES COCCOc1cnc2ccc(cc2c1)[C@H](C)n1nnc2ccn(-c3cc(C)ns3)c(=O)c12 |r| Show InChI InChI=1S/C23H22N6O3S/c1-14-10-21(33-26-14)28-7-6-20-22(23(28)30)29(27-25-20)15(2)16-4-5-19-17(11-16)12-18(13-24-19)32-9-8-31-3/h4-7,10-13,15H,8-9H2,1-3H3/t15-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of c-Met |
Bioorg Med Chem Lett 22: 4089-93 (2012)
Article DOI: 10.1016/j.bmcl.2012.04.072
BindingDB Entry DOI: 10.7270/Q2J67HZ2 |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50384128
(CHEMBL2029686)Show SMILES COCCOc1cnc2ccc(cc2c1)[C@H](C)n1nnc2ccn(-c3cc(F)cc(F)c3)c(=O)c12 |r| Show InChI InChI=1S/C25H21F2N5O3/c1-15(16-3-4-22-17(9-16)10-21(14-28-22)35-8-7-34-2)32-24-23(29-30-32)5-6-31(25(24)33)20-12-18(26)11-19(27)13-20/h3-6,9-15H,7-8H2,1-2H3/t15-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of c-Met |
Bioorg Med Chem Lett 22: 4089-93 (2012)
Article DOI: 10.1016/j.bmcl.2012.04.072
BindingDB Entry DOI: 10.7270/Q2J67HZ2 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50384121
(CHEMBL2029678)Show SMILES COCCOc1cnc2ccc(cc2c1)[C@H](C)n1nnc2ccn(-c3cc(C)ns3)c(=O)c12 |r| Show InChI InChI=1S/C23H22N6O3S/c1-14-10-21(33-26-14)28-7-6-20-22(23(28)30)29(27-25-20)15(2)16-4-5-19-17(11-16)12-18(13-24-19)32-9-8-31-3/h4-7,10-13,15H,8-9H2,1-3H3/t15-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of HGF-induced autophosphorylation of c-Met in human PC3 cells |
Bioorg Med Chem Lett 22: 4089-93 (2012)
Article DOI: 10.1016/j.bmcl.2012.04.072
BindingDB Entry DOI: 10.7270/Q2J67HZ2 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50384120
(CHEMBL2029565)Show SMILES COc1cnc2ccc(cc2c1)[C@H](C)n1nnc2ccn(-c3cc(C)ns3)c(=O)c12 |r| Show InChI InChI=1S/C21H18N6O2S/c1-12-8-19(30-24-12)26-7-6-18-20(21(26)28)27(25-23-18)13(2)14-4-5-17-15(9-14)10-16(29-3)11-22-17/h4-11,13H,1-3H3/t13-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of HGF-induced autophosphorylation of c-Met in human PC3 cells |
Bioorg Med Chem Lett 22: 4089-93 (2012)
Article DOI: 10.1016/j.bmcl.2012.04.072
BindingDB Entry DOI: 10.7270/Q2J67HZ2 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50384114
(CHEMBL2029680)Show SMILES COCCOc1cnc2ccc(cc2c1)[C@H](C)n1nnc2ccn(-c3cccs3)c(=O)c12 |r| Show InChI InChI=1S/C23H21N5O3S/c1-15(16-5-6-19-17(12-16)13-18(14-24-19)31-10-9-30-2)28-22-20(25-26-28)7-8-27(23(22)29)21-4-3-11-32-21/h3-8,11-15H,9-10H2,1-2H3/t15-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of c-Met |
Bioorg Med Chem Lett 22: 4089-93 (2012)
Article DOI: 10.1016/j.bmcl.2012.04.072
BindingDB Entry DOI: 10.7270/Q2J67HZ2 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50384119
(CHEMBL2029564)Show SMILES C[C@@H](c1ccc2ncccc2c1)n1nnc2ccn(-c3cc(C)ns3)c(=O)c12 |r| Show InChI InChI=1S/C20H16N6OS/c1-12-10-18(28-23-12)25-9-7-17-19(20(25)27)26(24-22-17)13(2)14-5-6-16-15(11-14)4-3-8-21-16/h3-11,13H,1-2H3/t13-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of c-Met |
Bioorg Med Chem Lett 22: 4089-93 (2012)
Article DOI: 10.1016/j.bmcl.2012.04.072
BindingDB Entry DOI: 10.7270/Q2J67HZ2 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50384118
(CHEMBL2029563)Show SMILES COCCOc1cnc2ccc(Cn3nnc4ccn(-c5cc(C)ns5)c(=O)c34)cc2c1 Show InChI InChI=1S/C22H20N6O3S/c1-14-9-20(32-25-14)27-6-5-19-21(22(27)29)28(26-24-19)13-15-3-4-18-16(10-15)11-17(12-23-18)31-8-7-30-2/h3-6,9-12H,7-8,13H2,1-2H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of HGF-induced autophosphorylation of c-Met in human PC3 cells |
Bioorg Med Chem Lett 22: 4089-93 (2012)
Article DOI: 10.1016/j.bmcl.2012.04.072
BindingDB Entry DOI: 10.7270/Q2J67HZ2 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50384129
(CHEMBL2029687)Show SMILES COCCOc1cnc2ccc(cc2c1)[C@H](C)n1nnc2ccn(-c3ccc(F)c(F)c3)c(=O)c12 |r| Show InChI InChI=1S/C25H21F2N5O3/c1-15(16-3-6-22-17(11-16)12-19(14-28-22)35-10-9-34-2)32-24-23(29-30-32)7-8-31(25(24)33)18-4-5-20(26)21(27)13-18/h3-8,11-15H,9-10H2,1-2H3/t15-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of c-Met |
Bioorg Med Chem Lett 22: 4089-93 (2012)
Article DOI: 10.1016/j.bmcl.2012.04.072
BindingDB Entry DOI: 10.7270/Q2J67HZ2 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50384117
(CHEMBL2029562)Show SMILES COc1cnc2ccc(Cn3nnc4ccn(-c5cc(C)ns5)c(=O)c34)cc2c1 Show InChI InChI=1S/C20H16N6O2S/c1-12-7-18(29-23-12)25-6-5-17-19(20(25)27)26(24-22-17)11-13-3-4-16-14(8-13)9-15(28-2)10-21-16/h3-10H,11H2,1-2H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of HGF-induced autophosphorylation of c-Met in human PC3 cells |
Bioorg Med Chem Lett 22: 4089-93 (2012)
Article DOI: 10.1016/j.bmcl.2012.04.072
BindingDB Entry DOI: 10.7270/Q2J67HZ2 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50384119
(CHEMBL2029564)Show SMILES C[C@@H](c1ccc2ncccc2c1)n1nnc2ccn(-c3cc(C)ns3)c(=O)c12 |r| Show InChI InChI=1S/C20H16N6OS/c1-12-10-18(28-23-12)25-9-7-17-19(20(25)27)26(24-22-17)13(2)14-5-6-16-15(11-14)4-3-8-21-16/h3-11,13H,1-2H3/t13-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of HGF-induced autophosphorylation of c-Met in human PC3 cells |
Bioorg Med Chem Lett 22: 4089-93 (2012)
Article DOI: 10.1016/j.bmcl.2012.04.072
BindingDB Entry DOI: 10.7270/Q2J67HZ2 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50384117
(CHEMBL2029562)Show SMILES COc1cnc2ccc(Cn3nnc4ccn(-c5cc(C)ns5)c(=O)c34)cc2c1 Show InChI InChI=1S/C20H16N6O2S/c1-12-7-18(29-23-12)25-6-5-17-19(20(25)27)26(24-22-17)11-13-3-4-16-14(8-13)9-15(28-2)10-21-16/h3-10H,11H2,1-2H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of c-Met |
Bioorg Med Chem Lett 22: 4089-93 (2012)
Article DOI: 10.1016/j.bmcl.2012.04.072
BindingDB Entry DOI: 10.7270/Q2J67HZ2 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50384116
(CHEMBL2029561)Show SMILES Cc1cc(sn1)-n1ccc2nnn(Cc3ccc4ncccc4c3)c2c1=O Show InChI InChI=1S/C19H14N6OS/c1-12-9-17(27-22-12)24-8-6-16-18(19(24)26)25(23-21-16)11-13-4-5-15-14(10-13)3-2-7-20-15/h2-10H,11H2,1H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of c-Met |
Bioorg Med Chem Lett 22: 4089-93 (2012)
Article DOI: 10.1016/j.bmcl.2012.04.072
BindingDB Entry DOI: 10.7270/Q2J67HZ2 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50384128
(CHEMBL2029686)Show SMILES COCCOc1cnc2ccc(cc2c1)[C@H](C)n1nnc2ccn(-c3cc(F)cc(F)c3)c(=O)c12 |r| Show InChI InChI=1S/C25H21F2N5O3/c1-15(16-3-4-22-17(9-16)10-21(14-28-22)35-8-7-34-2)32-24-23(29-30-32)5-6-31(25(24)33)20-12-18(26)11-19(27)13-20/h3-6,9-15H,7-8H2,1-2H3/t15-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of HGF-induced autophosphorylation of c-Met in human PC3 cells |
Bioorg Med Chem Lett 22: 4089-93 (2012)
Article DOI: 10.1016/j.bmcl.2012.04.072
BindingDB Entry DOI: 10.7270/Q2J67HZ2 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50384129
(CHEMBL2029687)Show SMILES COCCOc1cnc2ccc(cc2c1)[C@H](C)n1nnc2ccn(-c3ccc(F)c(F)c3)c(=O)c12 |r| Show InChI InChI=1S/C25H21F2N5O3/c1-15(16-3-6-22-17(11-16)12-19(14-28-22)35-10-9-34-2)32-24-23(29-30-32)7-8-31(25(24)33)18-4-5-20(26)21(27)13-18/h3-8,11-15H,9-10H2,1-2H3/t15-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of HGF-induced autophosphorylation of c-Met in human PC3 cells |
Bioorg Med Chem Lett 22: 4089-93 (2012)
Article DOI: 10.1016/j.bmcl.2012.04.072
BindingDB Entry DOI: 10.7270/Q2J67HZ2 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50384125
(CHEMBL2029683)Show SMILES C[C@@H](c1ccc2ncccc2c1)n1nnc2ccn(-c3cnn(C)c3)c(=O)c12 |r| Show InChI InChI=1S/C20H17N7O/c1-13(14-5-6-17-15(10-14)4-3-8-21-17)27-19-18(23-24-27)7-9-26(20(19)28)16-11-22-25(2)12-16/h3-13H,1-2H3/t13-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of c-Met |
Bioorg Med Chem Lett 22: 4089-93 (2012)
Article DOI: 10.1016/j.bmcl.2012.04.072
BindingDB Entry DOI: 10.7270/Q2J67HZ2 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50384116
(CHEMBL2029561)Show SMILES Cc1cc(sn1)-n1ccc2nnn(Cc3ccc4ncccc4c3)c2c1=O Show InChI InChI=1S/C19H14N6OS/c1-12-9-17(27-22-12)24-8-6-16-18(19(24)26)25(23-21-16)11-13-4-5-15-14(10-13)3-2-7-20-15/h2-10H,11H2,1H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of HGF-induced autophosphorylation of c-Met in human PC3 cells |
Bioorg Med Chem Lett 22: 4089-93 (2012)
Article DOI: 10.1016/j.bmcl.2012.04.072
BindingDB Entry DOI: 10.7270/Q2J67HZ2 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50384124
(CHEMBL2029682)Show SMILES C[C@@H](c1ccc2ncccc2c1)n1nnc2ccn(-c3ccc(C)s3)c(=O)c12 |r| Show InChI InChI=1S/C21H17N5OS/c1-13-5-8-19(28-13)25-11-9-18-20(21(25)27)26(24-23-18)14(2)15-6-7-17-16(12-15)4-3-10-22-17/h3-12,14H,1-2H3/t14-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of c-Met |
Bioorg Med Chem Lett 22: 4089-93 (2012)
Article DOI: 10.1016/j.bmcl.2012.04.072
BindingDB Entry DOI: 10.7270/Q2J67HZ2 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50384123
(CHEMBL2029681)Show SMILES C[C@@H](c1ccc2ncccc2c1)n1nnc2ccn(-c3cc(C)cs3)c(=O)c12 |r| Show InChI InChI=1S/C21H17N5OS/c1-13-10-19(28-12-13)25-9-7-18-20(21(25)27)26(24-23-18)14(2)15-5-6-17-16(11-15)4-3-8-22-17/h3-12,14H,1-2H3/t14-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of c-Met |
Bioorg Med Chem Lett 22: 4089-93 (2012)
Article DOI: 10.1016/j.bmcl.2012.04.072
BindingDB Entry DOI: 10.7270/Q2J67HZ2 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50384127
(CHEMBL2029685)Show SMILES COCCOc1cnc2ccc(Cn3nnc4ccn(-c5cc(F)cc(F)c5)c(=O)c34)cc2c1 Show InChI InChI=1S/C24H19F2N5O3/c1-33-6-7-34-20-9-16-8-15(2-3-21(16)27-13-20)14-31-23-22(28-29-31)4-5-30(24(23)32)19-11-17(25)10-18(26)12-19/h2-5,8-13H,6-7,14H2,1H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of c-Met |
Bioorg Med Chem Lett 22: 4089-93 (2012)
Article DOI: 10.1016/j.bmcl.2012.04.072
BindingDB Entry DOI: 10.7270/Q2J67HZ2 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50384122
(CHEMBL2029679)Show SMILES COCCOc1cnc2ccc(Cn3nnc4ccn(-c5cccs5)c(=O)c34)cc2c1 Show InChI InChI=1S/C22H19N5O3S/c1-29-8-9-30-17-12-16-11-15(4-5-18(16)23-13-17)14-27-21-19(24-25-27)6-7-26(22(21)28)20-3-2-10-31-20/h2-7,10-13H,8-9,14H2,1H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of c-Met |
Bioorg Med Chem Lett 22: 4089-93 (2012)
Article DOI: 10.1016/j.bmcl.2012.04.072
BindingDB Entry DOI: 10.7270/Q2J67HZ2 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50384126
(CHEMBL2029684)Show SMILES COc1cnc2ccc(Cn3nnc4ccn(-c5cc(F)cc(F)c5)c(=O)c34)cc2c1 Show InChI InChI=1S/C22H15F2N5O2/c1-31-18-7-14-6-13(2-3-19(14)25-11-18)12-29-21-20(26-27-29)4-5-28(22(21)30)17-9-15(23)8-16(24)10-17/h2-11H,12H2,1H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of c-Met |
Bioorg Med Chem Lett 22: 4089-93 (2012)
Article DOI: 10.1016/j.bmcl.2012.04.072
BindingDB Entry DOI: 10.7270/Q2J67HZ2 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50384114
(CHEMBL2029680)Show SMILES COCCOc1cnc2ccc(cc2c1)[C@H](C)n1nnc2ccn(-c3cccs3)c(=O)c12 |r| Show InChI InChI=1S/C23H21N5O3S/c1-15(16-5-6-19-17(12-16)13-18(14-24-19)31-10-9-30-2)28-22-20(25-26-28)7-8-27(23(22)29)21-4-3-11-32-21/h3-8,11-15H,9-10H2,1-2H3/t15-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of HGF-induced autophosphorylation of c-Met in human PC3 cells |
Bioorg Med Chem Lett 22: 4089-93 (2012)
Article DOI: 10.1016/j.bmcl.2012.04.072
BindingDB Entry DOI: 10.7270/Q2J67HZ2 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50384127
(CHEMBL2029685)Show SMILES COCCOc1cnc2ccc(Cn3nnc4ccn(-c5cc(F)cc(F)c5)c(=O)c34)cc2c1 Show InChI InChI=1S/C24H19F2N5O3/c1-33-6-7-34-20-9-16-8-15(2-3-21(16)27-13-20)14-31-23-22(28-29-31)4-5-30(24(23)32)19-11-17(25)10-18(26)12-19/h2-5,8-13H,6-7,14H2,1H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of HGF-induced autophosphorylation of c-Met in human PC3 cells |
Bioorg Med Chem Lett 22: 4089-93 (2012)
Article DOI: 10.1016/j.bmcl.2012.04.072
BindingDB Entry DOI: 10.7270/Q2J67HZ2 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50384123
(CHEMBL2029681)Show SMILES C[C@@H](c1ccc2ncccc2c1)n1nnc2ccn(-c3cc(C)cs3)c(=O)c12 |r| Show InChI InChI=1S/C21H17N5OS/c1-13-10-19(28-12-13)25-9-7-18-20(21(25)27)26(24-23-18)14(2)15-5-6-17-16(11-15)4-3-8-22-17/h3-12,14H,1-2H3/t14-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of HGF-induced autophosphorylation of c-Met in human PC3 cells |
Bioorg Med Chem Lett 22: 4089-93 (2012)
Article DOI: 10.1016/j.bmcl.2012.04.072
BindingDB Entry DOI: 10.7270/Q2J67HZ2 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50384125
(CHEMBL2029683)Show SMILES C[C@@H](c1ccc2ncccc2c1)n1nnc2ccn(-c3cnn(C)c3)c(=O)c12 |r| Show InChI InChI=1S/C20H17N7O/c1-13(14-5-6-17-15(10-14)4-3-8-21-17)27-19-18(23-24-27)7-9-26(20(19)28)16-11-22-25(2)12-16/h3-13H,1-2H3/t13-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 37 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of HGF-induced autophosphorylation of c-Met in human PC3 cells |
Bioorg Med Chem Lett 22: 4089-93 (2012)
Article DOI: 10.1016/j.bmcl.2012.04.072
BindingDB Entry DOI: 10.7270/Q2J67HZ2 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50384124
(CHEMBL2029682)Show SMILES C[C@@H](c1ccc2ncccc2c1)n1nnc2ccn(-c3ccc(C)s3)c(=O)c12 |r| Show InChI InChI=1S/C21H17N5OS/c1-13-5-8-19(28-13)25-11-9-18-20(21(25)27)26(24-23-18)14(2)15-6-7-17-16(12-15)4-3-10-22-17/h3-12,14H,1-2H3/t14-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 39 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of HGF-induced autophosphorylation of c-Met in human PC3 cells |
Bioorg Med Chem Lett 22: 4089-93 (2012)
Article DOI: 10.1016/j.bmcl.2012.04.072
BindingDB Entry DOI: 10.7270/Q2J67HZ2 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50384122
(CHEMBL2029679)Show SMILES COCCOc1cnc2ccc(Cn3nnc4ccn(-c5cccs5)c(=O)c34)cc2c1 Show InChI InChI=1S/C22H19N5O3S/c1-29-8-9-30-17-12-16-11-15(4-5-18(16)23-13-17)14-27-21-19(24-25-27)6-7-26(22(21)28)20-3-2-10-31-20/h2-7,10-13H,8-9,14H2,1H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 102 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of HGF-induced autophosphorylation of c-Met in human PC3 cells |
Bioorg Med Chem Lett 22: 4089-93 (2012)
Article DOI: 10.1016/j.bmcl.2012.04.072
BindingDB Entry DOI: 10.7270/Q2J67HZ2 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50384126
(CHEMBL2029684)Show SMILES COc1cnc2ccc(Cn3nnc4ccn(-c5cc(F)cc(F)c5)c(=O)c34)cc2c1 Show InChI InChI=1S/C22H15F2N5O2/c1-31-18-7-14-6-13(2-3-19(14)25-11-18)12-29-21-20(26-27-29)4-5-28(22(21)30)17-9-15(23)8-16(24)10-17/h2-11H,12H2,1H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of HGF-induced autophosphorylation of c-Met in human PC3 cells |
Bioorg Med Chem Lett 22: 4089-93 (2012)
Article DOI: 10.1016/j.bmcl.2012.04.072
BindingDB Entry DOI: 10.7270/Q2J67HZ2 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50384115
(CHEMBL2029688)Show InChI InChI=1S/C21H17N5O/c27-21-20-19(10-12-25(21)17-6-2-1-3-7-17)23-24-26(20)14-15-8-9-18-16(13-15)5-4-11-22-18/h1-9,11,13H,10,12,14H2 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
| PDB
Article
PubMed
| n/a | n/a | 612 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of c-Met |
Bioorg Med Chem Lett 22: 4089-93 (2012)
Article DOI: 10.1016/j.bmcl.2012.04.072
BindingDB Entry DOI: 10.7270/Q2J67HZ2 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
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