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PubMed code 22607877

Compile data set for download or QSAR
Found 38 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Aminopeptidase N


(Sus scrofa (Pig))		BDBM50385333
PNG
(CHEMBL2036152)
Show SMILES CC(C)C[C@H](NC(=O)NCCc1ccccc1)C(=O)NO |r|
Show InChI InChI=1S/C15H23N3O3/c1-11(2)10-13(14(19)18-21)17-15(20)16-9-8-12-6-4-3-5-7-12/h3-7,11,13,21H,8-10H2,1-2H3,(H,18,19)(H2,16,17,20)/t13-/m0/s1
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n/an/a 1.10E+3n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of pig kidney APN using L-Leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured after 30 mins by UV/VI...

Bioorg Med Chem 20: 3807-15 (2012)


Article DOI: 10.1016/j.bmc.2012.04.035
BindingDB Entry DOI: 10.7270/Q2B56KS2
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))		BDBM50385329
PNG
(CHEMBL2036148)
Show SMILES CSCC[C@H](NC(=O)NCc1ccccc1)C(=O)NO |r|
Show InChI InChI=1S/C13H19N3O3S/c1-20-8-7-11(12(17)16-19)15-13(18)14-9-10-5-3-2-4-6-10/h2-6,11,19H,7-9H2,1H3,(H,16,17)(H2,14,15,18)/t11-/m0/s1
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n/an/a 3.80E+3n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of pig kidney APN using L-Leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured after 30 mins by UV/VI...

Bioorg Med Chem 20: 3807-15 (2012)


Article DOI: 10.1016/j.bmc.2012.04.035
BindingDB Entry DOI: 10.7270/Q2B56KS2
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))		BDBM50385316
PNG
(CHEMBL2036146)
Show SMILES CC[C@H](C)[C@H](NC(=O)NCc1ccccc1)C(=O)NO |r|
Show InChI InChI=1S/C14H21N3O3/c1-3-10(2)12(13(18)17-20)16-14(19)15-9-11-7-5-4-6-8-11/h4-8,10,12,20H,3,9H2,1-2H3,(H,17,18)(H2,15,16,19)/t10-,12-/m0/s1
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n/an/a 4.10E+3n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of pig kidney APN using L-Leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured after 30 mins by UV/VI...

Bioorg Med Chem 20: 3807-15 (2012)


Article DOI: 10.1016/j.bmc.2012.04.035
BindingDB Entry DOI: 10.7270/Q2B56KS2
More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens (Human))		BDBM50385333
PNG
(CHEMBL2036152)
Show SMILES CC(C)C[C@H](NC(=O)NCCc1ccccc1)C(=O)NO |r|
Show InChI InChI=1S/C15H23N3O3/c1-11(2)10-13(14(19)18-21)17-15(20)16-9-8-12-6-4-3-5-7-12/h3-7,11,13,21H,8-10H2,1-2H3,(H,18,19)(H2,16,17,20)/t13-/m0/s1
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n/an/a 5.10E+3n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of APN in human ES2 cell surface using L-Leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured after 1...

Bioorg Med Chem 20: 3807-15 (2012)


Article DOI: 10.1016/j.bmc.2012.04.035
BindingDB Entry DOI: 10.7270/Q2B56KS2
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))		BDBM50385328
PNG
(CHEMBL2036147)
Show SMILES ONC(=O)[C@H](Cc1ccccc1)NC(=O)NCc1ccccc1 |r|
Show InChI InChI=1S/C17H19N3O3/c21-16(20-23)15(11-13-7-3-1-4-8-13)19-17(22)18-12-14-9-5-2-6-10-14/h1-10,15,23H,11-12H2,(H,20,21)(H2,18,19,22)/t15-/m0/s1
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n/an/a 5.60E+3n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of pig kidney APN using L-Leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured after 30 mins by UV/VI...

Bioorg Med Chem 20: 3807-15 (2012)


Article DOI: 10.1016/j.bmc.2012.04.035
BindingDB Entry DOI: 10.7270/Q2B56KS2
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))		BDBM50385335
PNG
(CHEMBL2036154)
Show SMILES ONC(=O)[C@H](Cc1ccccc1)NC(=O)NCCc1ccccc1 |r|
Show InChI InChI=1S/C18H21N3O3/c22-17(21-24)16(13-15-9-5-2-6-10-15)20-18(23)19-12-11-14-7-3-1-4-8-14/h1-10,16,24H,11-13H2,(H,21,22)(H2,19,20,23)/t16-/m0/s1
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n/an/a 6.50E+3n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of pig kidney APN using L-Leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured after 30 mins by UV/VI...

Bioorg Med Chem 20: 3807-15 (2012)


Article DOI: 10.1016/j.bmc.2012.04.035
BindingDB Entry DOI: 10.7270/Q2B56KS2
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))		BDBM23971
PNG
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1
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n/an/a 8.10E+3n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of pig kidney APN using L-Leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured after 30 mins by UV/VI...

Bioorg Med Chem 20: 3807-15 (2012)


Article DOI: 10.1016/j.bmc.2012.04.035
BindingDB Entry DOI: 10.7270/Q2B56KS2
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Aminopeptidase N


(Sus scrofa (Pig))		BDBM50385324
PNG
(CHEMBL2036141)
Show SMILES CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)NO |r|
Show InChI InChI=1S/C14H20N2O4/c1-10(2)8-12(13(17)16-19)15-14(18)20-9-11-6-4-3-5-7-11/h3-7,10,12,19H,8-9H2,1-2H3,(H,15,18)(H,16,17)/t12-/m0/s1
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n/an/a 9.10E+3n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of pig kidney APN using L-Leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured after 30 mins by UV/VI...

Bioorg Med Chem 20: 3807-15 (2012)


Article DOI: 10.1016/j.bmc.2012.04.035
BindingDB Entry DOI: 10.7270/Q2B56KS2
More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens (Human))		BDBM50385328
PNG
(CHEMBL2036147)
Show SMILES ONC(=O)[C@H](Cc1ccccc1)NC(=O)NCc1ccccc1 |r|
Show InChI InChI=1S/C17H19N3O3/c21-16(20-23)15(11-13-7-3-1-4-8-13)19-17(22)18-12-14-9-5-2-6-10-14/h1-10,15,23H,11-12H2,(H,20,21)(H2,18,19,22)/t15-/m0/s1
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n/an/a 1.60E+4n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of APN in human ES2 cell surface using L-Leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured after 1...

Bioorg Med Chem 20: 3807-15 (2012)


Article DOI: 10.1016/j.bmc.2012.04.035
BindingDB Entry DOI: 10.7270/Q2B56KS2
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))		BDBM50385327
PNG
(CHEMBL2036145)
Show SMILES CC(C)[C@H](NC(=O)NCc1ccccc1)C(=O)NO |r|
Show InChI InChI=1S/C13H19N3O3/c1-9(2)11(12(17)16-19)15-13(18)14-8-10-6-4-3-5-7-10/h3-7,9,11,19H,8H2,1-2H3,(H,16,17)(H2,14,15,18)/t11-/m0/s1
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n/an/a 1.70E+4n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of pig kidney APN using L-Leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured after 30 mins by UV/VI...

Bioorg Med Chem 20: 3807-15 (2012)


Article DOI: 10.1016/j.bmc.2012.04.035
BindingDB Entry DOI: 10.7270/Q2B56KS2
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))		BDBM50385315
PNG
(CHEMBL2036142)
Show SMILES CC(C)C[C@H](NC(=O)OCCc1ccccc1)C(=O)NO |r|
Show InChI InChI=1S/C15H22N2O4/c1-11(2)10-13(14(18)17-20)16-15(19)21-9-8-12-6-4-3-5-7-12/h3-7,11,13,20H,8-10H2,1-2H3,(H,16,19)(H,17,18)/t13-/m0/s1
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n/an/a 1.80E+4n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of pig kidney APN using L-Leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured after 30 mins by UV/VI...

Bioorg Med Chem 20: 3807-15 (2012)


Article DOI: 10.1016/j.bmc.2012.04.035
BindingDB Entry DOI: 10.7270/Q2B56KS2
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))		BDBM50385331
PNG
(CHEMBL2036150)
Show SMILES C[C@H](NC(=O)NCCc1ccccc1)C(=O)NO |r|
Show InChI InChI=1S/C12H17N3O3/c1-9(11(16)15-18)14-12(17)13-8-7-10-5-3-2-4-6-10/h2-6,9,18H,7-8H2,1H3,(H,15,16)(H2,13,14,17)/t9-/m0/s1
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n/an/a 2.10E+4n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of pig kidney APN using L-Leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured after 30 mins by UV/VI...

Bioorg Med Chem 20: 3807-15 (2012)


Article DOI: 10.1016/j.bmc.2012.04.035
BindingDB Entry DOI: 10.7270/Q2B56KS2
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))		BDBM50385326
PNG
(CHEMBL2036144)
Show SMILES C[C@H](NC(=O)NCc1ccccc1)C(=O)NO |r|
Show InChI InChI=1S/C11H15N3O3/c1-8(10(15)14-17)13-11(16)12-7-9-5-3-2-4-6-9/h2-6,8,17H,7H2,1H3,(H,14,15)(H2,12,13,16)/t8-/m0/s1
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n/an/a 2.10E+4n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of pig kidney APN using L-Leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured after 30 mins by UV/VI...

Bioorg Med Chem 20: 3807-15 (2012)


Article DOI: 10.1016/j.bmc.2012.04.035
BindingDB Entry DOI: 10.7270/Q2B56KS2
More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens (Human))		BDBM50385329
PNG
(CHEMBL2036148)
Show SMILES CSCC[C@H](NC(=O)NCc1ccccc1)C(=O)NO |r|
Show InChI InChI=1S/C13H19N3O3S/c1-20-8-7-11(12(17)16-19)15-13(18)14-9-10-5-3-2-4-6-10/h2-6,11,19H,7-9H2,1H3,(H,16,17)(H2,14,15,18)/t11-/m0/s1
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n/an/a 2.20E+4n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of APN in human ES2 cell surface using L-Leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured after 1...

Bioorg Med Chem 20: 3807-15 (2012)


Article DOI: 10.1016/j.bmc.2012.04.035
BindingDB Entry DOI: 10.7270/Q2B56KS2
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))		BDBM50385325
PNG
(CHEMBL2036143)
Show SMILES ONC(=O)CNC(=O)NCc1ccccc1
Show InChI InChI=1S/C10H13N3O3/c14-9(13-16)7-12-10(15)11-6-8-4-2-1-3-5-8/h1-5,16H,6-7H2,(H,13,14)(H2,11,12,15)
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n/an/a 3.20E+4n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of pig kidney APN using L-Leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured after 30 mins by UV/VI...

Bioorg Med Chem 20: 3807-15 (2012)


Article DOI: 10.1016/j.bmc.2012.04.035
BindingDB Entry DOI: 10.7270/Q2B56KS2
More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens (Human))		BDBM50385316
PNG
(CHEMBL2036146)
Show SMILES CC[C@H](C)[C@H](NC(=O)NCc1ccccc1)C(=O)NO |r|
Show InChI InChI=1S/C14H21N3O3/c1-3-10(2)12(13(18)17-20)16-14(19)15-9-11-7-5-4-6-8-11/h4-8,10,12,20H,3,9H2,1-2H3,(H,17,18)(H2,15,16,19)/t10-,12-/m0/s1
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n/an/a 3.90E+4n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of APN in human ES2 cell surface using L-Leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured after 1...

Bioorg Med Chem 20: 3807-15 (2012)


Article DOI: 10.1016/j.bmc.2012.04.035
BindingDB Entry DOI: 10.7270/Q2B56KS2
More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens (Human))		BDBM23971
PNG
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1
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n/an/a 4.00E+4n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of APN in human ES2 cell surface using L-Leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured after 1...

Bioorg Med Chem 20: 3807-15 (2012)


Article DOI: 10.1016/j.bmc.2012.04.035
BindingDB Entry DOI: 10.7270/Q2B56KS2
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Aminopeptidase N


(Sus scrofa (Pig))		BDBM50385330
PNG
(CHEMBL2036149)
Show SMILES ONC(=O)CNC(=O)NCCc1ccccc1
Show InChI InChI=1S/C11H15N3O3/c15-10(14-17)8-13-11(16)12-7-6-9-4-2-1-3-5-9/h1-5,17H,6-8H2,(H,14,15)(H2,12,13,16)
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n/an/a 5.20E+4n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of pig kidney APN using L-Leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured after 30 mins by UV/VI...

Bioorg Med Chem 20: 3807-15 (2012)


Article DOI: 10.1016/j.bmc.2012.04.035
BindingDB Entry DOI: 10.7270/Q2B56KS2
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))		BDBM50385317
PNG
(CHEMBL2035987)
Show SMILES CC(C)(C)NC(=O)NCC(=O)NO
Show InChI InChI=1S/C7H15N3O3/c1-7(2,3)9-6(12)8-4-5(11)10-13/h13H,4H2,1-3H3,(H,10,11)(H2,8,9,12)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of pig kidney APN using L-Leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured after 30 mins by UV/VI...

Bioorg Med Chem 20: 3807-15 (2012)


Article DOI: 10.1016/j.bmc.2012.04.035
BindingDB Entry DOI: 10.7270/Q2B56KS2
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))		BDBM50385322
PNG
(CHEMBL2036139)
Show SMILES CC(C)(C)NC(=O)N[C@@H](Cc1ccccc1)C(=O)NO |r|
Show InChI InChI=1S/C14H21N3O3/c1-14(2,3)16-13(19)15-11(12(18)17-20)9-10-7-5-4-6-8-10/h4-8,11,20H,9H2,1-3H3,(H,17,18)(H2,15,16,19)/t11-/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of pig kidney APN using L-Leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured after 30 mins by UV/VI...

Bioorg Med Chem 20: 3807-15 (2012)


Article DOI: 10.1016/j.bmc.2012.04.035
BindingDB Entry DOI: 10.7270/Q2B56KS2
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))		BDBM50385320
PNG
(CHEMBL2036137)
Show SMILES CC(C)C[C@H](NC(=O)NC(C)(C)C)C(=O)NO |r|
Show InChI InChI=1S/C11H23N3O3/c1-7(2)6-8(9(15)14-17)12-10(16)13-11(3,4)5/h7-8,17H,6H2,1-5H3,(H,14,15)(H2,12,13,16)/t8-/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of pig kidney APN using L-Leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured after 30 mins by UV/VI...

Bioorg Med Chem 20: 3807-15 (2012)


Article DOI: 10.1016/j.bmc.2012.04.035
BindingDB Entry DOI: 10.7270/Q2B56KS2
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))		BDBM50385332
PNG
(CHEMBL2036151)
Show SMILES CC(C)[C@H](NC(=O)NCCc1ccccc1)C(=O)NO |r|
Show InChI InChI=1S/C14H21N3O3/c1-10(2)12(13(18)17-20)16-14(19)15-9-8-11-6-4-3-5-7-11/h3-7,10,12,20H,8-9H2,1-2H3,(H,17,18)(H2,15,16,19)/t12-/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of pig kidney APN using L-Leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured after 30 mins by UV/VI...

Bioorg Med Chem 20: 3807-15 (2012)


Article DOI: 10.1016/j.bmc.2012.04.035
BindingDB Entry DOI: 10.7270/Q2B56KS2
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))		BDBM50385334
PNG
(CHEMBL2036153)
Show SMILES CC[C@H](C)[C@H](NC(=O)NCCc1ccccc1)C(=O)NO |r|
Show InChI InChI=1S/C15H23N3O3/c1-3-11(2)13(14(19)18-21)17-15(20)16-10-9-12-7-5-4-6-8-12/h4-8,11,13,21H,3,9-10H2,1-2H3,(H,18,19)(H2,16,17,20)/t11-,13-/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of pig kidney APN using L-Leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured after 30 mins by UV/VI...

Bioorg Med Chem 20: 3807-15 (2012)


Article DOI: 10.1016/j.bmc.2012.04.035
BindingDB Entry DOI: 10.7270/Q2B56KS2
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))		BDBM50385337
PNG
(CHEMBL2036156)
Show SMILES CC(C)C[C@H](NC(=O)NC1CCCCC1)C(=O)NO |r|
Show InChI InChI=1S/C13H25N3O3/c1-9(2)8-11(12(17)16-19)15-13(18)14-10-6-4-3-5-7-10/h9-11,19H,3-8H2,1-2H3,(H,16,17)(H2,14,15,18)/t11-/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of pig kidney APN using L-Leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured after 30 mins by UV/VI...

Bioorg Med Chem 20: 3807-15 (2012)


Article DOI: 10.1016/j.bmc.2012.04.035
BindingDB Entry DOI: 10.7270/Q2B56KS2
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))		BDBM50385323
PNG
(CHEMBL2036140)
Show SMILES CSCC[C@H](NC(=O)NC(C)(C)C)C(=O)NO |r|
Show InChI InChI=1S/C10H21N3O3S/c1-10(2,3)12-9(15)11-7(5-6-17-4)8(14)13-16/h7,16H,5-6H2,1-4H3,(H,13,14)(H2,11,12,15)/t7-/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of pig kidney APN using L-Leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured after 30 mins by UV/VI...

Bioorg Med Chem 20: 3807-15 (2012)


Article DOI: 10.1016/j.bmc.2012.04.035
BindingDB Entry DOI: 10.7270/Q2B56KS2
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))		BDBM50385321
PNG
(CHEMBL2036138)
Show SMILES CC[C@H](C)[C@H](NC(=O)NC(C)(C)C)C(=O)NO |r|
Show InChI InChI=1S/C11H23N3O3/c1-6-7(2)8(9(15)14-17)12-10(16)13-11(3,4)5/h7-8,17H,6H2,1-5H3,(H,14,15)(H2,12,13,16)/t7-,8-/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of pig kidney APN using L-Leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured after 30 mins by UV/VI...

Bioorg Med Chem 20: 3807-15 (2012)


Article DOI: 10.1016/j.bmc.2012.04.035
BindingDB Entry DOI: 10.7270/Q2B56KS2
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))		BDBM50385336
PNG
(CHEMBL2036155)
Show SMILES CSCC[C@H](NC(=O)NCCc1ccccc1)C(=O)NO |r|
Show InChI InChI=1S/C14H21N3O3S/c1-21-10-8-12(13(18)17-20)16-14(19)15-9-7-11-5-3-2-4-6-11/h2-6,12,20H,7-10H2,1H3,(H,17,18)(H2,15,16,19)/t12-/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of pig kidney APN using L-Leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured after 30 mins by UV/VI...

Bioorg Med Chem 20: 3807-15 (2012)


Article DOI: 10.1016/j.bmc.2012.04.035
BindingDB Entry DOI: 10.7270/Q2B56KS2
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))		BDBM50385338
PNG
(CHEMBL2036133)
Show SMILES CC(C)C[C@H](NC(=O)N[C@@H](CC(C)C)C(=O)NO)C(=O)NO |r|
Show InChI InChI=1S/C13H26N4O5/c1-7(2)5-9(11(18)16-21)14-13(20)15-10(6-8(3)4)12(19)17-22/h7-10,21-22H,5-6H2,1-4H3,(H,16,18)(H,17,19)(H2,14,15,20)/t9-,10-/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of pig kidney APN using L-Leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured after 30 mins by UV/VI...

Bioorg Med Chem 20: 3807-15 (2012)


Article DOI: 10.1016/j.bmc.2012.04.035
BindingDB Entry DOI: 10.7270/Q2B56KS2
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))		BDBM50385318
PNG
(CHEMBL2036135)
Show SMILES C[C@H](NC(=O)NC(C)(C)C)C(=O)NO |r|
Show InChI InChI=1S/C8H17N3O3/c1-5(6(12)11-14)9-7(13)10-8(2,3)4/h5,14H,1-4H3,(H,11,12)(H2,9,10,13)/t5-/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of pig kidney APN using L-Leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured after 30 mins by UV/VI...

Bioorg Med Chem 20: 3807-15 (2012)


Article DOI: 10.1016/j.bmc.2012.04.035
BindingDB Entry DOI: 10.7270/Q2B56KS2
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))		BDBM50385319
PNG
(CHEMBL2036136)
Show SMILES CC(C)[C@H](NC(=O)NC(C)(C)C)C(=O)NO |r|
Show InChI InChI=1S/C10H21N3O3/c1-6(2)7(8(14)13-16)11-9(15)12-10(3,4)5/h6-7,16H,1-5H3,(H,13,14)(H2,11,12,15)/t7-/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of pig kidney APN using L-Leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured after 30 mins by UV/VI...

Bioorg Med Chem 20: 3807-15 (2012)


Article DOI: 10.1016/j.bmc.2012.04.035
BindingDB Entry DOI: 10.7270/Q2B56KS2
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))		BDBM50385339
PNG
(CHEMBL2036134)
Show SMILES ONC(=O)[C@H](Cc1ccccc1)NC(=O)N[C@@H](Cc1ccccc1)C(=O)NO |r|
Show InChI InChI=1S/C19H22N4O5/c24-17(22-27)15(11-13-7-3-1-4-8-13)20-19(26)21-16(18(25)23-28)12-14-9-5-2-6-10-14/h1-10,15-16,27-28H,11-12H2,(H,22,24)(H,23,25)(H2,20,21,26)/t15-,16-/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of pig kidney APN using L-Leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured after 30 mins by UV/VI...

Bioorg Med Chem 20: 3807-15 (2012)


Article DOI: 10.1016/j.bmc.2012.04.035
BindingDB Entry DOI: 10.7270/Q2B56KS2
More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens (Human))		BDBM50385336
PNG
(CHEMBL2036155)
Show SMILES CSCC[C@H](NC(=O)NCCc1ccccc1)C(=O)NO |r|
Show InChI InChI=1S/C14H21N3O3S/c1-21-10-8-12(13(18)17-20)16-14(19)15-9-7-11-5-3-2-4-6-11/h2-6,12,20H,7-10H2,1H3,(H,17,18)(H2,15,16,19)/t12-/m0/s1
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n/an/a 1.10E+5n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of APN in human ES2 cell surface using L-Leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured after 1...

Bioorg Med Chem 20: 3807-15 (2012)


Article DOI: 10.1016/j.bmc.2012.04.035
BindingDB Entry DOI: 10.7270/Q2B56KS2
More data for this
Ligand-Target Pair
72 kDa type IV collagenase


(Homo sapiens (Human))		BDBM23971
PNG
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1
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n/an/a 1.56E+5n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of recombinant MMP2 using succinylated gelatin as substrate incubated for 10 mins prior to substrate addition measured after 1 hr by UV/VI...

Bioorg Med Chem 20: 3807-15 (2012)


Article DOI: 10.1016/j.bmc.2012.04.035
BindingDB Entry DOI: 10.7270/Q2B56KS2
More data for this
Ligand-Target Pair
72 kDa type IV collagenase


(Homo sapiens (Human))		BDBM50385328
PNG
(CHEMBL2036147)
Show SMILES ONC(=O)[C@H](Cc1ccccc1)NC(=O)NCc1ccccc1 |r|
Show InChI InChI=1S/C17H19N3O3/c21-16(20-23)15(11-13-7-3-1-4-8-13)19-17(22)18-12-14-9-5-2-6-10-14/h1-10,15,23H,11-12H2,(H,20,21)(H2,18,19,22)/t15-/m0/s1
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n/an/a>5.00E+5n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of recombinant MMP2 using succinylated gelatin as substrate incubated for 10 mins prior to substrate addition measured after 1 hr by UV/VI...

Bioorg Med Chem 20: 3807-15 (2012)


Article DOI: 10.1016/j.bmc.2012.04.035
BindingDB Entry DOI: 10.7270/Q2B56KS2
More data for this
Ligand-Target Pair
72 kDa type IV collagenase


(Homo sapiens (Human))		BDBM50385336
PNG
(CHEMBL2036155)
Show SMILES CSCC[C@H](NC(=O)NCCc1ccccc1)C(=O)NO |r|
Show InChI InChI=1S/C14H21N3O3S/c1-21-10-8-12(13(18)17-20)16-14(19)15-9-7-11-5-3-2-4-6-11/h2-6,12,20H,7-10H2,1H3,(H,17,18)(H2,15,16,19)/t12-/m0/s1
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n/an/a>5.00E+5n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of recombinant MMP2 using succinylated gelatin as substrate incubated for 10 mins prior to substrate addition measured after 1 hr by UV/VI...

Bioorg Med Chem 20: 3807-15 (2012)


Article DOI: 10.1016/j.bmc.2012.04.035
BindingDB Entry DOI: 10.7270/Q2B56KS2
More data for this
Ligand-Target Pair
72 kDa type IV collagenase


(Homo sapiens (Human))		BDBM50385316
PNG
(CHEMBL2036146)
Show SMILES CC[C@H](C)[C@H](NC(=O)NCc1ccccc1)C(=O)NO |r|
Show InChI InChI=1S/C14H21N3O3/c1-3-10(2)12(13(18)17-20)16-14(19)15-9-11-7-5-4-6-8-11/h4-8,10,12,20H,3,9H2,1-2H3,(H,17,18)(H2,15,16,19)/t10-,12-/m0/s1
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n/an/a>5.00E+5n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of recombinant MMP2 using succinylated gelatin as substrate incubated for 10 mins prior to substrate addition measured after 1 hr by UV/VI...

Bioorg Med Chem 20: 3807-15 (2012)


Article DOI: 10.1016/j.bmc.2012.04.035
BindingDB Entry DOI: 10.7270/Q2B56KS2
More data for this
Ligand-Target Pair
72 kDa type IV collagenase


(Homo sapiens (Human))		BDBM50385333
PNG
(CHEMBL2036152)
Show SMILES CC(C)C[C@H](NC(=O)NCCc1ccccc1)C(=O)NO |r|
Show InChI InChI=1S/C15H23N3O3/c1-11(2)10-13(14(19)18-21)17-15(20)16-9-8-12-6-4-3-5-7-12/h3-7,11,13,21H,8-10H2,1-2H3,(H,18,19)(H2,16,17,20)/t13-/m0/s1
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n/an/a>5.00E+5n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of recombinant MMP2 using succinylated gelatin as substrate incubated for 10 mins prior to substrate addition measured after 1 hr by UV/VI...

Bioorg Med Chem 20: 3807-15 (2012)


Article DOI: 10.1016/j.bmc.2012.04.035
BindingDB Entry DOI: 10.7270/Q2B56KS2
More data for this
Ligand-Target Pair
72 kDa type IV collagenase


(Homo sapiens (Human))		BDBM50385329
PNG
(CHEMBL2036148)
Show SMILES CSCC[C@H](NC(=O)NCc1ccccc1)C(=O)NO |r|
Show InChI InChI=1S/C13H19N3O3S/c1-20-8-7-11(12(17)16-19)15-13(18)14-9-10-5-3-2-4-6-10/h2-6,11,19H,7-9H2,1H3,(H,16,17)(H2,14,15,18)/t11-/m0/s1
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n/an/a>5.00E+5n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of recombinant MMP2 using succinylated gelatin as substrate incubated for 10 mins prior to substrate addition measured after 1 hr by UV/VI...

Bioorg Med Chem 20: 3807-15 (2012)


Article DOI: 10.1016/j.bmc.2012.04.035
BindingDB Entry DOI: 10.7270/Q2B56KS2
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%