Found 16 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50387167
(CHEMBL2047981)Show SMILES FC(F)(F)c1cnc([nH]1)-c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 Show InChI InChI=1S/C23H14ClF6N5O2/c24-17-6-3-13(9-16(17)22(25,26)27)34-21(36)33-12-1-4-14(5-2-12)37-15-7-8-31-18(10-15)20-32-11-19(35-20)23(28,29)30/h1-11H,(H,32,35)(H2,33,34,36) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 10.6 | n/a | n/a | n/a | n/a | n/a | n/a |
Academy of Military Medical Science
Curated by ChEMBL
| Assay Description
Inhibition of C-Raf kinase-mediated phosphorylation of Mek using [33P]gammaATP after 20 mins by scintillation counting |
Bioorg Med Chem 20: 4323-9 (2012)
Article DOI: 10.1016/j.bmc.2012.05.051
BindingDB Entry DOI: 10.7270/Q2VM4D93 |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50387168
(CHEMBL2047982)Show SMILES FC(F)(F)c1cnc([nH]1)-c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(Cl)c3)cc2)ccn1 Show InChI InChI=1S/C22H14Cl2F3N5O2/c23-16-6-3-13(9-17(16)24)31-21(33)30-12-1-4-14(5-2-12)34-15-7-8-28-18(10-15)20-29-11-19(32-20)22(25,26)27/h1-11H,(H,29,32)(H2,30,31,33) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 13.1 | n/a | n/a | n/a | n/a | n/a | n/a |
Academy of Military Medical Science
Curated by ChEMBL
| Assay Description
Inhibition of C-Raf kinase-mediated phosphorylation of Mek using [33P]gammaATP after 20 mins by scintillation counting |
Bioorg Med Chem 20: 4323-9 (2012)
Article DOI: 10.1016/j.bmc.2012.05.051
BindingDB Entry DOI: 10.7270/Q2VM4D93 |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50387178
(CHEMBL2047994)Show SMILES FC(F)(F)c1cnc([nH]1)-c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(Cl)c3)c(Cl)c2)ccn1 Show InChI InChI=1S/C22H13Cl3F3N5O2/c23-14-3-1-11(7-15(14)24)31-21(34)32-17-4-2-12(8-16(17)25)35-13-5-6-29-18(9-13)20-30-10-19(33-20)22(26,27)28/h1-10H,(H,30,33)(H2,31,32,34) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 16.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Academy of Military Medical Science
Curated by ChEMBL
| Assay Description
Inhibition of C-Raf kinase-mediated phosphorylation of Mek using [33P]gammaATP after 20 mins by scintillation counting |
Bioorg Med Chem 20: 4323-9 (2012)
Article DOI: 10.1016/j.bmc.2012.05.051
BindingDB Entry DOI: 10.7270/Q2VM4D93 |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50387176
(CHEMBL2047992)Show SMILES FC(F)(F)c1cnc([nH]1)-c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)c(Cl)c2)ccn1 Show InChI InChI=1S/C23H13Cl2F6N5O2/c24-15-3-1-11(7-14(15)22(26,27)28)34-21(37)35-17-4-2-12(8-16(17)25)38-13-5-6-32-18(9-13)20-33-10-19(36-20)23(29,30)31/h1-10H,(H,33,36)(H2,34,35,37) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 22.1 | n/a | n/a | n/a | n/a | n/a | n/a |
Academy of Military Medical Science
Curated by ChEMBL
| Assay Description
Inhibition of C-Raf kinase-mediated phosphorylation of Mek using [33P]gammaATP after 20 mins by scintillation counting |
Bioorg Med Chem 20: 4323-9 (2012)
Article DOI: 10.1016/j.bmc.2012.05.051
BindingDB Entry DOI: 10.7270/Q2VM4D93 |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM16673
(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)Show SMILES CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 Show InChI InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| DrugBank
Article
PubMed
| n/a | n/a | 24.3 | n/a | n/a | n/a | n/a | n/a | n/a |
Academy of Military Medical Science
Curated by ChEMBL
| Assay Description
Inhibition of C-Raf kinase-mediated phosphorylation of Mek using [33P]gammaATP after 20 mins by scintillation counting |
Bioorg Med Chem 20: 4323-9 (2012)
Article DOI: 10.1016/j.bmc.2012.05.051
BindingDB Entry DOI: 10.7270/Q2VM4D93 |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50387175
(CHEMBL2047991)Show SMILES FC(F)(F)c1cnc([nH]1)-c1cc(Oc2ccc(NC(=O)Nc3cc(ccc3Cl)C(F)(F)F)c(Cl)c2)ccn1 Show InChI InChI=1S/C23H13Cl2F6N5O2/c24-14-3-1-11(22(26,27)28)7-17(14)35-21(37)34-16-4-2-12(8-15(16)25)38-13-5-6-32-18(9-13)20-33-10-19(36-20)23(29,30)31/h1-10H,(H,33,36)(H2,34,35,37) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 35.9 | n/a | n/a | n/a | n/a | n/a | n/a |
Academy of Military Medical Science
Curated by ChEMBL
| Assay Description
Inhibition of C-Raf kinase-mediated phosphorylation of Mek using [33P]gammaATP after 20 mins by scintillation counting |
Bioorg Med Chem 20: 4323-9 (2012)
Article DOI: 10.1016/j.bmc.2012.05.051
BindingDB Entry DOI: 10.7270/Q2VM4D93 |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50387177
(CHEMBL2047993)Show SMILES Cc1ccc(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3ncc([nH]3)C(F)(F)F)cc2Cl)cc1C(F)(F)F Show InChI InChI=1S/C24H16ClF6N5O2/c1-12-2-3-13(8-16(12)23(26,27)28)34-22(37)35-18-5-4-14(9-17(18)25)38-15-6-7-32-19(10-15)21-33-11-20(36-21)24(29,30)31/h2-11H,1H3,(H,33,36)(H2,34,35,37) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 46.7 | n/a | n/a | n/a | n/a | n/a | n/a |
Academy of Military Medical Science
Curated by ChEMBL
| Assay Description
Inhibition of C-Raf kinase-mediated phosphorylation of Mek using [33P]gammaATP after 20 mins by scintillation counting |
Bioorg Med Chem 20: 4323-9 (2012)
Article DOI: 10.1016/j.bmc.2012.05.051
BindingDB Entry DOI: 10.7270/Q2VM4D93 |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50387164
(CHEMBL2047995)Show SMILES FC(F)(F)c1cnc([nH]1)-c1cc(Oc2ccc(NC(=O)Nc3cccc(c3)C(F)(F)F)c(Cl)c2)ccn1 Show InChI InChI=1S/C23H14ClF6N5O2/c24-16-9-14(37-15-6-7-31-18(10-15)20-32-11-19(35-20)23(28,29)30)4-5-17(16)34-21(36)33-13-3-1-2-12(8-13)22(25,26)27/h1-11H,(H,32,35)(H2,33,34,36) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 64.8 | n/a | n/a | n/a | n/a | n/a | n/a |
Academy of Military Medical Science
Curated by ChEMBL
| Assay Description
Inhibition of C-Raf kinase-mediated phosphorylation of Mek using [33P]gammaATP after 20 mins by scintillation counting |
Bioorg Med Chem 20: 4323-9 (2012)
Article DOI: 10.1016/j.bmc.2012.05.051
BindingDB Entry DOI: 10.7270/Q2VM4D93 |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50387169
(CHEMBL2047983)Show SMILES Fc1ccc(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3ncc([nH]3)C(F)(F)F)cc2)cc1Cl Show InChI InChI=1S/C22H14ClF4N5O2/c23-16-9-13(3-6-17(16)24)31-21(33)30-12-1-4-14(5-2-12)34-15-7-8-28-18(10-15)20-29-11-19(32-20)22(25,26)27/h1-11H,(H,29,32)(H2,30,31,33) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 69.2 | n/a | n/a | n/a | n/a | n/a | n/a |
Academy of Military Medical Science
Curated by ChEMBL
| Assay Description
Inhibition of C-Raf kinase-mediated phosphorylation of Mek using [33P]gammaATP after 20 mins by scintillation counting |
Bioorg Med Chem 20: 4323-9 (2012)
Article DOI: 10.1016/j.bmc.2012.05.051
BindingDB Entry DOI: 10.7270/Q2VM4D93 |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50387166
(CHEMBL2047980)Show SMILES FC(F)(F)c1cnc([nH]1)-c1cc(Oc2ccc(NC(=O)Nc3cc(ccc3Cl)C(F)(F)F)cc2)ccn1 Show InChI InChI=1S/C23H14ClF6N5O2/c24-16-6-1-12(22(25,26)27)9-17(16)34-21(36)33-13-2-4-14(5-3-13)37-15-7-8-31-18(10-15)20-32-11-19(35-20)23(28,29)30/h1-11H,(H,32,35)(H2,33,34,36) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 75.9 | n/a | n/a | n/a | n/a | n/a | n/a |
Academy of Military Medical Science
Curated by ChEMBL
| Assay Description
Inhibition of C-Raf kinase-mediated phosphorylation of Mek using [33P]gammaATP after 20 mins by scintillation counting |
Bioorg Med Chem 20: 4323-9 (2012)
Article DOI: 10.1016/j.bmc.2012.05.051
BindingDB Entry DOI: 10.7270/Q2VM4D93 |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50387174
(CHEMBL2047990)Show SMILES Fc1ccc(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3ncc([nH]3)C(F)(F)F)cc2Cl)cc1C(F)(F)F Show InChI InChI=1S/C23H13ClF7N5O2/c24-15-8-12(38-13-5-6-32-18(9-13)20-33-10-19(36-20)23(29,30)31)2-4-17(15)35-21(37)34-11-1-3-16(25)14(7-11)22(26,27)28/h1-10H,(H,33,36)(H2,34,35,37) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 77.7 | n/a | n/a | n/a | n/a | n/a | n/a |
Academy of Military Medical Science
Curated by ChEMBL
| Assay Description
Inhibition of C-Raf kinase-mediated phosphorylation of Mek using [33P]gammaATP after 20 mins by scintillation counting |
Bioorg Med Chem 20: 4323-9 (2012)
Article DOI: 10.1016/j.bmc.2012.05.051
BindingDB Entry DOI: 10.7270/Q2VM4D93 |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50387170
(CHEMBL2047984)Show SMILES Fc1cc(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3ncc([nH]3)C(F)(F)F)cc2)ccc1Br Show InChI InChI=1S/C22H14BrF4N5O2/c23-16-6-3-13(9-17(16)24)31-21(33)30-12-1-4-14(5-2-12)34-15-7-8-28-18(10-15)20-29-11-19(32-20)22(25,26)27/h1-11H,(H,29,32)(H2,30,31,33) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 81.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Academy of Military Medical Science
Curated by ChEMBL
| Assay Description
Inhibition of C-Raf kinase-mediated phosphorylation of Mek using [33P]gammaATP after 20 mins by scintillation counting |
Bioorg Med Chem 20: 4323-9 (2012)
Article DOI: 10.1016/j.bmc.2012.05.051
BindingDB Entry DOI: 10.7270/Q2VM4D93 |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50387165
(CHEMBL2047979)Show SMILES FC(F)(F)c1cnc([nH]1)-c1cc(Oc2ccc(NC(=O)Nc3cccc(c3)C(F)(F)F)cc2)ccn1 Show InChI InChI=1S/C23H15F6N5O2/c24-22(25,26)13-2-1-3-15(10-13)33-21(35)32-14-4-6-16(7-5-14)36-17-8-9-30-18(11-17)20-31-12-19(34-20)23(27,28)29/h1-12H,(H,31,34)(H2,32,33,35) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 87.8 | n/a | n/a | n/a | n/a | n/a | n/a |
Academy of Military Medical Science
Curated by ChEMBL
| Assay Description
Inhibition of C-Raf kinase-mediated phosphorylation of Mek using [33P]gammaATP after 20 mins by scintillation counting |
Bioorg Med Chem 20: 4323-9 (2012)
Article DOI: 10.1016/j.bmc.2012.05.051
BindingDB Entry DOI: 10.7270/Q2VM4D93 |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50387171
(CHEMBL2047985)Show SMILES Fc1ccc(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3ncc([nH]3)C(F)(F)F)cc2)cc1 Show InChI InChI=1S/C22H15F4N5O2/c23-13-1-3-14(4-2-13)29-21(32)30-15-5-7-16(8-6-15)33-17-9-10-27-18(11-17)20-28-12-19(31-20)22(24,25)26/h1-12H,(H,28,31)(H2,29,30,32) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 94.9 | n/a | n/a | n/a | n/a | n/a | n/a |
Academy of Military Medical Science
Curated by ChEMBL
| Assay Description
Inhibition of C-Raf kinase-mediated phosphorylation of Mek using [33P]gammaATP after 20 mins by scintillation counting |
Bioorg Med Chem 20: 4323-9 (2012)
Article DOI: 10.1016/j.bmc.2012.05.051
BindingDB Entry DOI: 10.7270/Q2VM4D93 |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50387172
(CHEMBL2047986)Show SMILES Cc1cccc(Cl)c1NC(=O)Nc1ccc(Oc2ccnc(c2)-c2ncc([nH]2)C(F)(F)F)cc1 Show InChI InChI=1S/C23H17ClF3N5O2/c1-13-3-2-4-17(24)20(13)32-22(33)30-14-5-7-15(8-6-14)34-16-9-10-28-18(11-16)21-29-12-19(31-21)23(25,26)27/h2-12H,1H3,(H,29,31)(H2,30,32,33) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
Academy of Military Medical Science
Curated by ChEMBL
| Assay Description
Inhibition of C-Raf kinase-mediated phosphorylation of Mek using [33P]gammaATP after 20 mins by scintillation counting |
Bioorg Med Chem 20: 4323-9 (2012)
Article DOI: 10.1016/j.bmc.2012.05.051
BindingDB Entry DOI: 10.7270/Q2VM4D93 |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50387173
(CHEMBL2047988)Show SMILES Cc1cc(NC(=O)Nc2ccc(Oc3ccnc(c3)-c3ncc([nH]3)C(F)(F)F)cc2)no1 Show InChI InChI=1S/C20H15F3N6O3/c1-11-8-17(29-32-11)28-19(30)26-12-2-4-13(5-3-12)31-14-6-7-24-15(9-14)18-25-10-16(27-18)20(21,22)23/h2-10H,1H3,(H,25,27)(H2,26,28,29,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 148 | n/a | n/a | n/a | n/a | n/a | n/a |
Academy of Military Medical Science
Curated by ChEMBL
| Assay Description
Inhibition of C-Raf kinase-mediated phosphorylation of Mek using [33P]gammaATP after 20 mins by scintillation counting |
Bioorg Med Chem 20: 4323-9 (2012)
Article DOI: 10.1016/j.bmc.2012.05.051
BindingDB Entry DOI: 10.7270/Q2VM4D93 |
More data for this
Ligand-Target Pair | |
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