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PubMed code 22738271

Compile Data Set for Download or QSAR

Found 250 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50395162
PNG
(CHEMBL2163935)
Show SMILES CCCC1COc2cccc3c2n1cc(C(=O)NC1CCCCC1)c3=O
Show InChI InChI=1S/C21H26N2O3/c1-2-7-15-13-26-18-11-6-10-16-19(18)23(15)12-17(20(16)24)21(25)22-14-8-4-3-5-9-14/h6,10-12,14-15H,2-5,7-9,13H2,1H3,(H,22,25)
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0.320n/an/an/an/an/an/an/an/a



Universit£ di Ferrara

Curated by ChEMBL


Assay Description
Displacement of [3H]CP-55940 from human recombinant CB2 receptor expressed in CHO cell membranes incubated for 60 mins by scintillation counting


J Med Chem 55: 6608-23 (2012)


Article DOI: 10.1021/jm300763w
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50395178
PNG
(CHEMBL2163950)
Show SMILES O=C(NC1CCCCCC1)c1cn2C(COc3cccc(c23)c1=O)c1ccccc1
Show InChI InChI=1S/C25H26N2O3/c28-24-19-13-8-14-22-23(19)27(21(16-30-22)17-9-4-3-5-10-17)15-20(24)25(29)26-18-11-6-1-2-7-12-18/h3-5,8-10,13-15,18,21H,1-2,6-7,11-12,16H2,(H,26,29)
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0.810n/an/an/an/an/an/an/an/a



Universit£ di Ferrara

Curated by ChEMBL


Assay Description
Displacement of [3H]CP-55940 from human recombinant CB2 receptor expressed in CHO cell membranes incubated for 60 mins by scintillation counting


J Med Chem 55: 6608-23 (2012)


Article DOI: 10.1021/jm300763w
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50395140
PNG
(CHEMBL2163926)
Show SMILES CC(C)[C@@H]1COc2cccc3c2n1cc(C(=O)NC12CC4CC(CC(C4)C1)C2)c3=O |r,THB:23:22:19:25.24.26,23:24:21.22.27:19,26:24:21:27.18.19,26:18:21:25.23.24|
Show InChI InChI=1S/C25H30N2O3/c1-14(2)20-13-30-21-5-3-4-18-22(21)27(20)12-19(23(18)28)24(29)26-25-9-15-6-16(10-25)8-17(7-15)11-25/h3-5,12,14-17,20H,6-11,13H2,1-2H3,(H,26,29)/t15?,16?,17?,20-,25?/m0/s1
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1.24n/an/an/an/an/an/an/an/a



Universit£ di Ferrara

Curated by ChEMBL


Assay Description
Displacement of [3H]CP-55940 from human recombinant CB2 receptor expressed in CHO cell membranes incubated for 60 mins by scintillation counting


J Med Chem 55: 6608-23 (2012)


Article DOI: 10.1021/jm300763w
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))
BDBM50395140
PNG
(CHEMBL2163926)
Show SMILES CC(C)[C@@H]1COc2cccc3c2n1cc(C(=O)NC12CC4CC(CC(C4)C1)C2)c3=O |r,THB:23:22:19:25.24.26,23:24:21.22.27:19,26:24:21:27.18.19,26:18:21:25.23.24|
Show InChI InChI=1S/C25H30N2O3/c1-14(2)20-13-30-21-5-3-4-18-22(21)27(20)12-19(23(18)28)24(29)26-25-9-15-6-16(10-25)8-17(7-15)11-25/h3-5,12,14-17,20H,6-11,13H2,1-2H3,(H,26,29)/t15?,16?,17?,20-,25?/m0/s1
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1.75n/an/an/an/an/an/an/an/a



Universit£ di Ferrara

Curated by ChEMBL


Assay Description
Displacement of [3H]CP-55940 from CB2 receptor in Sprague-Dawley rat spleen by scintillation counting


J Med Chem 55: 6608-23 (2012)


Article DOI: 10.1021/jm300763w
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))
BDBM50395162
PNG
(CHEMBL2163935)
Show SMILES CCCC1COc2cccc3c2n1cc(C(=O)NC1CCCCC1)c3=O
Show InChI InChI=1S/C21H26N2O3/c1-2-7-15-13-26-18-11-6-10-16-19(18)23(15)12-17(20(16)24)21(25)22-14-8-4-3-5-9-14/h6,10-12,14-15H,2-5,7-9,13H2,1H3,(H,22,25)
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1.84n/an/an/an/an/an/an/an/a



Universit£ di Ferrara

Curated by ChEMBL


Assay Description
Displacement of [3H]CP-55940 from CB2 receptor in Sprague-Dawley rat spleen by scintillation counting


J Med Chem 55: 6608-23 (2012)


Article DOI: 10.1021/jm300763w
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50395161
PNG
(CHEMBL2163937)
Show SMILES CCCC1COc2cccc3c2n1cc(C(=O)NC12CC4CC(CC(C4)C1)C2)c3=O |THB:23:22:19:25.24.26,23:24:21.22.27:19,26:24:21:27.18.19,26:18:21:25.23.24|
Show InChI InChI=1S/C25H30N2O3/c1-2-4-18-14-30-21-6-3-5-19-22(21)27(18)13-20(23(19)28)24(29)26-25-10-15-7-16(11-25)9-17(8-15)12-25/h3,5-6,13,15-18H,2,4,7-12,14H2,1H3,(H,26,29)
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2.34n/an/an/an/an/an/an/an/a



Universit£ di Ferrara

Curated by ChEMBL


Assay Description
Displacement of [3H]CP-55940 from human recombinant CB2 receptor expressed in CHO cell membranes incubated for 60 mins by scintillation counting


J Med Chem 55: 6608-23 (2012)


Article DOI: 10.1021/jm300763w
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50395179
PNG
(CHEMBL2163949)
Show SMILES O=C(NC1CCCCC1)c1cn2C(COc3cccc(c23)c1=O)c1ccccc1
Show InChI InChI=1S/C24H24N2O3/c27-23-18-12-7-13-21-22(18)26(20(15-29-21)16-8-3-1-4-9-16)14-19(23)24(28)25-17-10-5-2-6-11-17/h1,3-4,7-9,12-14,17,20H,2,5-6,10-11,15H2,(H,25,28)
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2.52n/an/an/an/an/an/an/an/a



Universit£ di Ferrara

Curated by ChEMBL


Assay Description
Displacement of [3H]CP-55940 from human recombinant CB2 receptor expressed in CHO cell membranes incubated for 60 mins by scintillation counting


J Med Chem 55: 6608-23 (2012)


Article DOI: 10.1021/jm300763w
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))
BDBM50395161
PNG
(CHEMBL2163937)
Show SMILES CCCC1COc2cccc3c2n1cc(C(=O)NC12CC4CC(CC(C4)C1)C2)c3=O |THB:23:22:19:25.24.26,23:24:21.22.27:19,26:24:21:27.18.19,26:18:21:25.23.24|
Show InChI InChI=1S/C25H30N2O3/c1-2-4-18-14-30-21-6-3-5-19-22(21)27(18)13-20(23(19)28)24(29)26-25-10-15-7-16(11-25)9-17(8-15)12-25/h3,5-6,13,15-18H,2,4,7-12,14H2,1H3,(H,26,29)
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2.73n/an/an/an/an/an/an/an/a



Universit£ di Ferrara

Curated by ChEMBL


Assay Description
Displacement of [3H]CP-55940 from CB2 receptor in Sprague-Dawley rat spleen by scintillation counting


J Med Chem 55: 6608-23 (2012)


Article DOI: 10.1021/jm300763w
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50395156
PNG
(CHEMBL2163942)
Show SMILES O=C(NC1CCCCCC1)c1cn2C(COc3cccc(c23)c1=O)C1CC1
Show InChI InChI=1S/C22H26N2O3/c25-21-16-8-5-9-19-20(16)24(18(13-27-19)14-10-11-14)12-17(21)22(26)23-15-6-3-1-2-4-7-15/h5,8-9,12,14-15,18H,1-4,6-7,10-11,13H2,(H,23,26)
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3.12n/an/an/an/an/an/an/an/a



Universit£ di Ferrara

Curated by ChEMBL


Assay Description
Displacement of [3H]CP-55940 from human recombinant CB2 receptor expressed in CHO cell membranes incubated for 60 mins by scintillation counting


J Med Chem 55: 6608-23 (2012)


Article DOI: 10.1021/jm300763w
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50395176
PNG
(CHEMBL2163952)
Show SMILES CC12CC3CC(C)(C1)CC(C3)(C2)NC(=O)c1cn2C(COc3cccc(c23)c1=O)c1ccccc1 |TLB:6:5:11:2.3.10,4:5:11:2.3.10,4:3:7.5.8:11,12:9:7:2.4.3,10:9:7:2.4.3,THB:10:3:7:8.9.11|
Show InChI InChI=1S/C30H32N2O3/c1-28-11-19-12-29(2,16-28)18-30(13-19,17-28)31-27(34)22-14-32-23(20-7-4-3-5-8-20)15-35-24-10-6-9-21(25(24)32)26(22)33/h3-10,14,19,23H,11-13,15-18H2,1-2H3,(H,31,34)
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3.45n/an/an/an/an/an/an/an/a



Universit£ di Ferrara

Curated by ChEMBL


Assay Description
Displacement of [3H]CP-55940 from human recombinant CB2 receptor expressed in CHO cell membranes incubated for 60 mins by scintillation counting


J Med Chem 55: 6608-23 (2012)


Article DOI: 10.1021/jm300763w
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))
BDBM50395156
PNG
(CHEMBL2163942)
Show SMILES O=C(NC1CCCCCC1)c1cn2C(COc3cccc(c23)c1=O)C1CC1
Show InChI InChI=1S/C22H26N2O3/c25-21-16-8-5-9-19-20(16)24(18(13-27-19)14-10-11-14)12-17(21)22(26)23-15-6-3-1-2-4-7-15/h5,8-9,12,14-15,18H,1-4,6-7,10-11,13H2,(H,23,26)
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3.52n/an/an/an/an/an/an/an/a



Universit£ di Ferrara

Curated by ChEMBL


Assay Description
Displacement of [3H]CP-55940 from CB2 receptor in Sprague-Dawley rat spleen by scintillation counting


J Med Chem 55: 6608-23 (2012)


Article DOI: 10.1021/jm300763w
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50395160
PNG
(CHEMBL2163938)
Show SMILES CCCC1COc2cccc3c2n1cc(C(=O)NC12CC4CC(C)(CC(C)(C4)C1)C2)c3=O |TLB:27:25:29:21.20.19,27:20:24.25.28:29,26:25:29:21.20.19,THB:19:20:24:28.18.29,19:18:24:21.27.20|
Show InChI InChI=1S/C27H34N2O3/c1-4-6-18-13-32-21-8-5-7-19-22(21)29(18)12-20(23(19)30)24(31)28-27-11-17-9-25(2,15-27)14-26(3,10-17)16-27/h5,7-8,12,17-18H,4,6,9-11,13-16H2,1-3H3,(H,28,31)
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3.62n/an/an/an/an/an/an/an/a



Universit£ di Ferrara

Curated by ChEMBL


Assay Description
Displacement of [3H]CP-55940 from human recombinant CB2 receptor expressed in CHO cell membranes incubated for 60 mins by scintillation counting


J Med Chem 55: 6608-23 (2012)


Article DOI: 10.1021/jm300763w
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50395137
PNG
(CHEMBL2163929)
Show SMILES O=C(NC12CC3CC(CC(C3)C1)C2)c1cn2[C@H](Cc3ccccc3)COc3cccc(c23)c1=O |r,THB:8:7:4:10.9.11,8:9:6.7.12:4,11:9:6:12.3.4,11:3:6:10.8.9|
Show InChI InChI=1S/C29H30N2O3/c32-27-23-7-4-8-25-26(23)31(22(17-34-25)12-18-5-2-1-3-6-18)16-24(27)28(33)30-29-13-19-9-20(14-29)11-21(10-19)15-29/h1-8,16,19-22H,9-15,17H2,(H,30,33)/t19?,20?,21?,22-,29?/m1/s1
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3.72n/an/an/an/an/an/an/an/a



Universit£ di Ferrara

Curated by ChEMBL


Assay Description
Displacement of [3H]CP-55940 from human recombinant CB2 receptor expressed in CHO cell membranes incubated for 60 mins by scintillation counting


J Med Chem 55: 6608-23 (2012)


Article DOI: 10.1021/jm300763w
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50395139
PNG
(CHEMBL2163927)
Show SMILES CC(C)[C@H]1COc2cccc3c2n1cc(C(=O)NC12CC4CC(CC(C4)C1)C2)c3=O |r,THB:23:22:19:25.24.26,23:24:21.22.27:19,26:24:21:27.18.19,26:18:21:25.23.24|
Show InChI InChI=1S/C25H30N2O3/c1-14(2)20-13-30-21-5-3-4-18-22(21)27(20)12-19(23(18)28)24(29)26-25-9-15-6-16(10-25)8-17(7-15)11-25/h3-5,12,14-17,20H,6-11,13H2,1-2H3,(H,26,29)/t15?,16?,17?,20-,25?/m1/s1
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3.74n/an/an/an/an/an/an/an/a



Universit£ di Ferrara

Curated by ChEMBL


Assay Description
Displacement of [3H]CP-55940 from human recombinant CB2 receptor expressed in CHO cell membranes incubated for 60 mins by scintillation counting


J Med Chem 55: 6608-23 (2012)


Article DOI: 10.1021/jm300763w
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50395144
PNG
(CHEMBL2163577)
Show SMILES CC[C@@H]1COc2cccc3c2n1cc(C(=O)NC1CCCCCC1)c3=O |r|
Show InChI InChI=1S/C21H26N2O3/c1-2-15-13-26-18-11-7-10-16-19(18)23(15)12-17(20(16)24)21(25)22-14-8-5-3-4-6-9-14/h7,10-12,14-15H,2-6,8-9,13H2,1H3,(H,22,25)/t15-/m1/s1
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4.12n/an/an/an/an/an/an/an/a



Universit£ di Ferrara

Curated by ChEMBL


Assay Description
Displacement of [3H]CP-55940 from human recombinant CB2 receptor expressed in CHO cell membranes incubated for 60 mins by scintillation counting


J Med Chem 55: 6608-23 (2012)


Article DOI: 10.1021/jm300763w
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))
BDBM50395139
PNG
(CHEMBL2163927)
Show SMILES CC(C)[C@H]1COc2cccc3c2n1cc(C(=O)NC12CC4CC(CC(C4)C1)C2)c3=O |r,THB:23:22:19:25.24.26,23:24:21.22.27:19,26:24:21:27.18.19,26:18:21:25.23.24|
Show InChI InChI=1S/C25H30N2O3/c1-14(2)20-13-30-21-5-3-4-18-22(21)27(20)12-19(23(18)28)24(29)26-25-9-15-6-16(10-25)8-17(7-15)11-25/h3-5,12,14-17,20H,6-11,13H2,1-2H3,(H,26,29)/t15?,16?,17?,20-,25?/m1/s1
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4.22n/an/an/an/an/an/an/an/a



Universit£ di Ferrara

Curated by ChEMBL


Assay Description
Displacement of [3H]CP-55940 from CB2 receptor in Sprague-Dawley rat spleen by scintillation counting


J Med Chem 55: 6608-23 (2012)


Article DOI: 10.1021/jm300763w
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM21281
PNG
((11R)-2-methyl-11-(morpholin-4-ylmethyl)-3-(naphth...)
Show SMILES Cc1c(C(=O)c2cccc3ccccc23)c2cccc3OC[C@@H](CN4CCOCC4)n1c23 |r|
Show InChI InChI=1S/C27H26N2O3/c1-18-25(27(30)22-9-4-7-19-6-2-3-8-21(19)22)23-10-5-11-24-26(23)29(18)20(17-32-24)16-28-12-14-31-15-13-28/h2-11,20H,12-17H2,1H3/t20-/m1/s1
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4.53n/an/an/an/an/an/an/an/a



Universit£ di Ferrara

Curated by ChEMBL


Assay Description
Displacement of [3H]CP-55940 from human recombinant CB2 receptor expressed in CHO cell membranes incubated for 60 mins by scintillation counting


J Med Chem 55: 6608-23 (2012)


Article DOI: 10.1021/jm300763w
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))
BDBM50395137
PNG
(CHEMBL2163929)
Show SMILES O=C(NC12CC3CC(CC(C3)C1)C2)c1cn2[C@H](Cc3ccccc3)COc3cccc(c23)c1=O |r,THB:8:7:4:10.9.11,8:9:6.7.12:4,11:9:6:12.3.4,11:3:6:10.8.9|
Show InChI InChI=1S/C29H30N2O3/c32-27-23-7-4-8-25-26(23)31(22(17-34-25)12-18-5-2-1-3-6-18)16-24(27)28(33)30-29-13-19-9-20(14-29)11-21(10-19)15-29/h1-8,16,19-22H,9-15,17H2,(H,30,33)/t19?,20?,21?,22-,29?/m1/s1
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4.65n/an/an/an/an/an/an/an/a



Universit£ di Ferrara

Curated by ChEMBL


Assay Description
Displacement of [3H]CP-55940 from CB2 receptor in Sprague-Dawley rat spleen by scintillation counting


J Med Chem 55: 6608-23 (2012)


Article DOI: 10.1021/jm300763w
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50395142
PNG
(CHEMBL2163579)
Show SMILES CC[C@@H]1COc2cccc3c2n1cc(C(=O)NC12CC4CC(CC(C4)C1)C2)c3=O |r,THB:22:21:18:24.23.25,22:23:20.21.26:18,25:23:20:26.17.18,25:17:20:24.22.23|
Show InChI InChI=1S/C24H28N2O3/c1-2-17-13-29-20-5-3-4-18-21(20)26(17)12-19(22(18)27)23(28)25-24-9-14-6-15(10-24)8-16(7-14)11-24/h3-5,12,14-17H,2,6-11,13H2,1H3,(H,25,28)/t14?,15?,16?,17-,24?/m1/s1
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4.93n/an/an/an/an/an/an/an/a



Universit£ di Ferrara

Curated by ChEMBL


Assay Description
Displacement of [3H]CP-55940 from human recombinant CB2 receptor expressed in CHO cell membranes incubated for 60 mins by scintillation counting


J Med Chem 55: 6608-23 (2012)


Article DOI: 10.1021/jm300763w
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))
BDBM50395144
PNG
(CHEMBL2163577)
Show SMILES CC[C@@H]1COc2cccc3c2n1cc(C(=O)NC1CCCCCC1)c3=O |r|
Show InChI InChI=1S/C21H26N2O3/c1-2-15-13-26-18-11-7-10-16-19(18)23(15)12-17(20(16)24)21(25)22-14-8-5-3-4-6-9-14/h7,10-12,14-15H,2-6,8-9,13H2,1H3,(H,22,25)/t15-/m1/s1
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6.03n/an/an/an/an/an/an/an/a



Universit£ di Ferrara

Curated by ChEMBL


Assay Description
Displacement of [3H]CP-55940 from CB2 receptor in Sprague-Dawley rat spleen by scintillation counting


J Med Chem 55: 6608-23 (2012)


Article DOI: 10.1021/jm300763w
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))
BDBM50395142
PNG
(CHEMBL2163579)
Show SMILES CC[C@@H]1COc2cccc3c2n1cc(C(=O)NC12CC4CC(CC(C4)C1)C2)c3=O |r,THB:22:21:18:24.23.25,22:23:20.21.26:18,25:23:20:26.17.18,25:17:20:24.22.23|
Show InChI InChI=1S/C24H28N2O3/c1-2-17-13-29-20-5-3-4-18-21(20)26(17)12-19(22(18)27)23(28)25-24-9-14-6-15(10-24)8-16(7-14)11-24/h3-5,12,14-17H,2,6-11,13H2,1H3,(H,25,28)/t14?,15?,16?,17-,24?/m1/s1
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6.17n/an/an/an/an/an/an/an/a



Universit£ di Ferrara

Curated by ChEMBL


Assay Description
Displacement of [3H]CP-55940 from CB2 receptor in Sprague-Dawley rat spleen by scintillation counting


J Med Chem 55: 6608-23 (2012)


Article DOI: 10.1021/jm300763w
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50395151
PNG
(CHEMBL2163948)
Show SMILES CCC1COc2c(OC)ccc3c2n1cc(C(=O)NC12CC4CC(CC(C4)C1)C2)c3=O |THB:24:23:20:26.25.27,24:25:22.23.28:20,27:25:22:28.19.20,27:19:22:26.24.25|
Show InChI InChI=1S/C25H30N2O4/c1-3-17-13-31-23-20(30-2)5-4-18-21(23)27(17)12-19(22(18)28)24(29)26-25-9-14-6-15(10-25)8-16(7-14)11-25/h4-5,12,14-17H,3,6-11,13H2,1-2H3,(H,26,29)
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6.78n/an/an/an/an/an/an/an/a



Universit£ di Ferrara

Curated by ChEMBL


Assay Description
Displacement of [3H]CP-55940 from human recombinant CB2 receptor expressed in CHO cell membranes incubated for 60 mins by scintillation counting


J Med Chem 55: 6608-23 (2012)


Article DOI: 10.1021/jm300763w
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50395153
PNG
(CHEMBL2163946)
Show SMILES CCC1COc2c(F)ccc3c2n1cc(C(=O)NC12CC4CC(CC(C4)C1)C2)c3=O |THB:23:22:19:25.24.26,23:24:21.22.27:19,26:24:21:27.18.19,26:18:21:25.23.24|
Show InChI InChI=1S/C24H27FN2O3/c1-2-16-12-30-22-19(25)4-3-17-20(22)27(16)11-18(21(17)28)23(29)26-24-8-13-5-14(9-24)7-15(6-13)10-24/h3-4,11,13-16H,2,5-10,12H2,1H3,(H,26,29)
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7.34n/an/an/an/an/an/an/an/a



Universit£ di Ferrara

Curated by ChEMBL


Assay Description
Displacement of [3H]CP-55940 from human recombinant CB2 receptor expressed in CHO cell membranes incubated for 60 mins by scintillation counting


J Med Chem 55: 6608-23 (2012)


Article DOI: 10.1021/jm300763w
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))
BDBM21281
PNG
((11R)-2-methyl-11-(morpholin-4-ylmethyl)-3-(naphth...)
Show SMILES Cc1c(C(=O)c2cccc3ccccc23)c2cccc3OC[C@@H](CN4CCOCC4)n1c23 |r|
Show InChI InChI=1S/C27H26N2O3/c1-18-25(27(30)22-9-4-7-19-6-2-3-8-21(19)22)23-10-5-11-24-26(23)29(18)20(17-32-24)16-28-12-14-31-15-13-28/h2-11,20H,12-17H2,1H3/t20-/m1/s1
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7.58n/an/an/an/an/an/an/an/a



Universit£ di Ferrara

Curated by ChEMBL


Assay Description
Displacement of [3H]CP-55940 from CB2 receptor in Sprague-Dawley rat spleen by scintillation counting


J Med Chem 55: 6608-23 (2012)


Article DOI: 10.1021/jm300763w
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50350156
PNG
(CHEMBL1814463)
Show SMILES CCC1COc2cccc3c2n1cc(C(=O)NC12CC4CC(CC(C4)C1)C2)c3=O |TLB:16:17:20.19.24:22,THB:18:19:22:26.17.25,18:17:20.19.24:22,25:17:20:24.23.22,25:23:20:26.18.17|
Show InChI InChI=1S/C24H28N2O3/c1-2-17-13-29-20-5-3-4-18-21(20)26(17)12-19(22(18)27)23(28)25-24-9-14-6-15(10-24)8-16(7-14)11-24/h3-5,12,14-17H,2,6-11,13H2,1H3,(H,25,28)
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7.83n/an/an/an/an/an/an/an/a



Universit£ di Ferrara

Curated by ChEMBL


Assay Description
Displacement of [3H]CP-55940 from human recombinant CB2 receptor expressed in CHO cell membranes incubated for 60 mins by scintillation counting


J Med Chem 55: 6608-23 (2012)


Article DOI: 10.1021/jm300763w
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50395150
PNG
(CHEMBL2163571)
Show SMILES CCC1COc2c(ccc3c2n1cc(C(=O)NC12CC4CC(CC(C4)C1)C2)c3=O)N1CCCC1 |THB:22:21:18:24.23.25,22:23:20.21.26:18,25:23:20:26.17.18,25:17:20:24.22.23|
Show InChI InChI=1S/C28H35N3O3/c1-2-20-16-34-26-23(30-7-3-4-8-30)6-5-21-24(26)31(20)15-22(25(21)32)27(33)29-28-12-17-9-18(13-28)11-19(10-17)14-28/h5-6,15,17-20H,2-4,7-14,16H2,1H3,(H,29,33)
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8.12n/an/an/an/an/an/an/an/a



Universit£ di Ferrara

Curated by ChEMBL


Assay Description
Displacement of [3H]CP-55940 from human recombinant CB2 receptor expressed in CHO cell membranes incubated for 60 mins by scintillation counting


J Med Chem 55: 6608-23 (2012)


Article DOI: 10.1021/jm300763w
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50395155
PNG
(CHEMBL2163943)
Show SMILES O=C(NC12CC3CC(CC(C3)C1)C2)c1cn2C(COc3cccc(c23)c1=O)C1CC1 |THB:8:7:4:10.9.11,8:9:6.7.12:4,11:9:6:12.3.4,11:3:6:10.8.9|
Show InChI InChI=1S/C25H28N2O3/c28-23-18-2-1-3-21-22(18)27(20(13-30-21)17-4-5-17)12-19(23)24(29)26-25-9-14-6-15(10-25)8-16(7-14)11-25/h1-3,12,14-17,20H,4-11,13H2,(H,26,29)
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8.92n/an/an/an/an/an/an/an/a



Universit£ di Ferrara

Curated by ChEMBL


Assay Description
Displacement of [3H]CP-55940 from human recombinant CB2 receptor expressed in CHO cell membranes incubated for 60 mins by scintillation counting


J Med Chem 55: 6608-23 (2012)


Article DOI: 10.1021/jm300763w
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))
BDBM50395151
PNG
(CHEMBL2163948)
Show SMILES CCC1COc2c(OC)ccc3c2n1cc(C(=O)NC12CC4CC(CC(C4)C1)C2)c3=O |THB:24:23:20:26.25.27,24:25:22.23.28:20,27:25:22:28.19.20,27:19:22:26.24.25|
Show InChI InChI=1S/C25H30N2O4/c1-3-17-13-31-23-20(30-2)5-4-18-21(23)27(17)12-19(22(18)28)24(29)26-25-9-14-6-15(10-25)8-16(7-14)11-25/h4-5,12,14-17H,3,6-11,13H2,1-2H3,(H,26,29)
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9.12n/an/an/an/an/an/an/an/a



Universit£ di Ferrara

Curated by ChEMBL


Assay Description
Displacement of [3H]CP-55940 from CB2 receptor in Sprague-Dawley rat spleen by scintillation counting


J Med Chem 55: 6608-23 (2012)


Article DOI: 10.1021/jm300763w
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50395143
PNG
(CHEMBL2163578)
Show SMILES CC[C@H]1COc2cccc3c2n1cc(C(=O)NC1CCCCCC1)c3=O |r|
Show InChI InChI=1S/C21H26N2O3/c1-2-15-13-26-18-11-7-10-16-19(18)23(15)12-17(20(16)24)21(25)22-14-8-5-3-4-6-9-14/h7,10-12,14-15H,2-6,8-9,13H2,1H3,(H,22,25)/t15-/m0/s1
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9.24n/an/an/an/an/an/an/an/a



Universit£ di Ferrara

Curated by ChEMBL


Assay Description
Displacement of [3H]CP-55940 from human recombinant CB2 receptor expressed in CHO cell membranes incubated for 60 mins by scintillation counting


J Med Chem 55: 6608-23 (2012)


Article DOI: 10.1021/jm300763w
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50395138
PNG
(CHEMBL2163928)
Show SMILES CC(C)C[C@@H]1COc2cccc3c2n1cc(C(=O)NC12CC4CC(CC(C4)C1)C2)c3=O |r,THB:24:23:20:26.25.27,24:25:22.23.28:20,27:25:22:28.19.20,27:19:22:26.24.25|
Show InChI InChI=1S/C26H32N2O3/c1-15(2)6-19-14-31-22-5-3-4-20-23(22)28(19)13-21(24(20)29)25(30)27-26-10-16-7-17(11-26)9-18(8-16)12-26/h3-5,13,15-19H,6-12,14H2,1-2H3,(H,27,30)/t16?,17?,18?,19-,26?/m1/s1
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9.24n/an/an/an/an/an/an/an/a



Universit£ di Ferrara

Curated by ChEMBL


Assay Description
Displacement of [3H]CP-55940 from human recombinant CB2 receptor expressed in CHO cell membranes incubated for 60 mins by scintillation counting


J Med Chem 55: 6608-23 (2012)


Article DOI: 10.1021/jm300763w
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))
BDBM50395153
PNG
(CHEMBL2163946)
Show SMILES CCC1COc2c(F)ccc3c2n1cc(C(=O)NC12CC4CC(CC(C4)C1)C2)c3=O |THB:23:22:19:25.24.26,23:24:21.22.27:19,26:24:21:27.18.19,26:18:21:25.23.24|
Show InChI InChI=1S/C24H27FN2O3/c1-2-16-12-30-22-19(25)4-3-17-20(22)27(16)11-18(21(17)28)23(29)26-24-8-13-5-14(9-24)7-15(6-13)10-24/h3-4,11,13-16H,2,5-10,12H2,1H3,(H,26,29)
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9.51n/an/an/an/an/an/an/an/a



Universit£ di Ferrara

Curated by ChEMBL


Assay Description
Displacement of [3H]CP-55940 from CB2 receptor in Sprague-Dawley rat spleen by scintillation counting


J Med Chem 55: 6608-23 (2012)


Article DOI: 10.1021/jm300763w
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50395162
PNG
(CHEMBL2163935)
Show SMILES CCCC1COc2cccc3c2n1cc(C(=O)NC1CCCCC1)c3=O
Show InChI InChI=1S/C21H26N2O3/c1-2-7-15-13-26-18-11-6-10-16-19(18)23(15)12-17(20(16)24)21(25)22-14-8-4-3-5-9-14/h6,10-12,14-15H,2-5,7-9,13H2,1H3,(H,22,25)
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10.2n/an/an/an/an/an/an/an/a



Universit£ di Ferrara

Curated by ChEMBL


Assay Description
Displacement of [3H]CP-55940 from human recombinant CB1 receptor expressed in CHO cell membranes incubated for 90 mins by scintillation counting


J Med Chem 55: 6608-23 (2012)


Article DOI: 10.1021/jm300763w
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))
BDBM50395138
PNG
(CHEMBL2163928)
Show SMILES CC(C)C[C@@H]1COc2cccc3c2n1cc(C(=O)NC12CC4CC(CC(C4)C1)C2)c3=O |r,THB:24:23:20:26.25.27,24:25:22.23.28:20,27:25:22:28.19.20,27:19:22:26.24.25|
Show InChI InChI=1S/C26H32N2O3/c1-15(2)6-19-14-31-22-5-3-4-20-23(22)28(19)13-21(24(20)29)25(30)27-26-10-16-7-17(11-26)9-18(8-16)12-26/h3-5,13,15-19H,6-12,14H2,1-2H3,(H,27,30)/t16?,17?,18?,19-,26?/m1/s1
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10.2n/an/an/an/an/an/an/an/a



Universit£ di Ferrara

Curated by ChEMBL


Assay Description
Displacement of [3H]CP-55940 from CB2 receptor in Sprague-Dawley rat spleen by scintillation counting


J Med Chem 55: 6608-23 (2012)


Article DOI: 10.1021/jm300763w
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))
BDBM50395155
PNG
(CHEMBL2163943)
Show SMILES O=C(NC12CC3CC(CC(C3)C1)C2)c1cn2C(COc3cccc(c23)c1=O)C1CC1 |THB:8:7:4:10.9.11,8:9:6.7.12:4,11:9:6:12.3.4,11:3:6:10.8.9|
Show InChI InChI=1S/C25H28N2O3/c28-23-18-2-1-3-21-22(18)27(20(13-30-21)17-4-5-17)12-19(23)24(29)26-25-9-14-6-15(10-25)8-16(7-14)11-25/h1-3,12,14-17,20H,4-11,13H2,(H,26,29)
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10.3n/an/an/an/an/an/an/an/a



Universit£ di Ferrara

Curated by ChEMBL


Assay Description
Displacement of [3H]CP-55940 from CB2 receptor in Sprague-Dawley rat spleen by scintillation counting


J Med Chem 55: 6608-23 (2012)


Article DOI: 10.1021/jm300763w
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50395158
PNG
(CHEMBL2163940)
Show SMILES CCCC1COc2ccc(C)c3c2n1cc(C(=O)NC12CC4CC(CC(C4)C1)C2)c3=O |THB:24:23:20:26.25.27,24:25:22.23.28:20,27:25:22:28.19.20,27:19:22:26.24.25|
Show InChI InChI=1S/C26H32N2O3/c1-3-4-19-14-31-21-6-5-15(2)22-23(21)28(19)13-20(24(22)29)25(30)27-26-10-16-7-17(11-26)9-18(8-16)12-26/h5-6,13,16-19H,3-4,7-12,14H2,1-2H3,(H,27,30)
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10.4n/an/an/an/an/an/an/an/a



Universit£ di Ferrara

Curated by ChEMBL


Assay Description
Displacement of [3H]CP-55940 from human recombinant CB2 receptor expressed in CHO cell membranes incubated for 60 mins by scintillation counting


J Med Chem 55: 6608-23 (2012)


Article DOI: 10.1021/jm300763w
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))
BDBM50395150
PNG
(CHEMBL2163571)
Show SMILES CCC1COc2c(ccc3c2n1cc(C(=O)NC12CC4CC(CC(C4)C1)C2)c3=O)N1CCCC1 |THB:22:21:18:24.23.25,22:23:20.21.26:18,25:23:20:26.17.18,25:17:20:24.22.23|
Show InChI InChI=1S/C28H35N3O3/c1-2-20-16-34-26-23(30-7-3-4-8-30)6-5-21-24(26)31(20)15-22(25(21)32)27(33)29-28-12-17-9-18(13-28)11-19(10-17)14-28/h5-6,15,17-20H,2-4,7-14,16H2,1H3,(H,29,33)
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10.5n/an/an/an/an/an/an/an/a



Universit£ di Ferrara

Curated by ChEMBL


Assay Description
Displacement of [3H]CP-55940 from CB2 receptor in Sprague-Dawley rat spleen by scintillation counting


J Med Chem 55: 6608-23 (2012)


Article DOI: 10.1021/jm300763w
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))
BDBM50395160
PNG
(CHEMBL2163938)
Show SMILES CCCC1COc2cccc3c2n1cc(C(=O)NC12CC4CC(C)(CC(C)(C4)C1)C2)c3=O |TLB:27:25:29:21.20.19,27:20:24.25.28:29,26:25:29:21.20.19,THB:19:20:24:28.18.29,19:18:24:21.27.20|
Show InChI InChI=1S/C27H34N2O3/c1-4-6-18-13-32-21-8-5-7-19-22(21)29(18)12-20(23(19)30)24(31)28-27-11-17-9-25(2,15-27)14-26(3,10-17)16-27/h5,7-8,12,17-18H,4,6,9-11,13-16H2,1-3H3,(H,28,31)
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10.7n/an/an/an/an/an/an/an/a



Universit£ di Ferrara

Curated by ChEMBL


Assay Description
Displacement of [3H]CP-55940 from CB2 receptor in Sprague-Dawley rat spleen by scintillation counting


J Med Chem 55: 6608-23 (2012)


Article DOI: 10.1021/jm300763w
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))
BDBM50395143
PNG
(CHEMBL2163578)
Show SMILES CC[C@H]1COc2cccc3c2n1cc(C(=O)NC1CCCCCC1)c3=O |r|
Show InChI InChI=1S/C21H26N2O3/c1-2-15-13-26-18-11-7-10-16-19(18)23(15)12-17(20(16)24)21(25)22-14-8-5-3-4-6-9-14/h7,10-12,14-15H,2-6,8-9,13H2,1H3,(H,22,25)/t15-/m0/s1
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11.4n/an/an/an/an/an/an/an/a



Universit£ di Ferrara

Curated by ChEMBL


Assay Description
Displacement of [3H]CP-55940 from CB2 receptor in Sprague-Dawley rat spleen by scintillation counting


J Med Chem 55: 6608-23 (2012)


Article DOI: 10.1021/jm300763w
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM21281
PNG
((11R)-2-methyl-11-(morpholin-4-ylmethyl)-3-(naphth...)
Show SMILES Cc1c(C(=O)c2cccc3ccccc23)c2cccc3OC[C@@H](CN4CCOCC4)n1c23 |r|
Show InChI InChI=1S/C27H26N2O3/c1-18-25(27(30)22-9-4-7-19-6-2-3-8-21(19)22)23-10-5-11-24-26(23)29(18)20(17-32-24)16-28-12-14-31-15-13-28/h2-11,20H,12-17H2,1H3/t20-/m1/s1
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12.4n/an/an/an/an/an/an/an/a



Universit£ di Ferrara

Curated by ChEMBL


Assay Description
Displacement of [3H]CP-55940 from human recombinant CB1 receptor expressed in CHO cell membranes incubated for 90 mins by scintillation counting


J Med Chem 55: 6608-23 (2012)


Article DOI: 10.1021/jm300763w
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))
BDBM50395158
PNG
(CHEMBL2163940)
Show SMILES CCCC1COc2ccc(C)c3c2n1cc(C(=O)NC12CC4CC(CC(C4)C1)C2)c3=O |THB:24:23:20:26.25.27,24:25:22.23.28:20,27:25:22:28.19.20,27:19:22:26.24.25|
Show InChI InChI=1S/C26H32N2O3/c1-3-4-19-14-31-21-6-5-15(2)22-23(21)28(19)13-20(24(22)29)25(30)27-26-10-16-7-17(11-26)9-18(8-16)12-26/h5-6,13,16-19H,3-4,7-12,14H2,1-2H3,(H,27,30)
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13.2n/an/an/an/an/an/an/an/a



Universit£ di Ferrara

Curated by ChEMBL


Assay Description
Displacement of [3H]CP-55940 from CB2 receptor in Sprague-Dawley rat spleen by scintillation counting


J Med Chem 55: 6608-23 (2012)


Article DOI: 10.1021/jm300763w
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50395167
PNG
(CHEMBL2163930)
Show SMILES CCC1COc2cccc3c2n1cc(C(=O)NC1C2CC4CC(C2)CC1C4)c3=O |TLB:26:25:23:19.20.21,THB:26:20:17.25.24:23,16:17:23:19.20.21,21:20:17:24.22.23,21:22:17:19.26.20,(22.66,-38.66,;22.67,-37.12,;21.34,-36.34,;20.01,-37.1,;18.68,-36.32,;18.69,-34.79,;17.36,-34.02,;17.36,-32.48,;18.69,-31.71,;20.03,-32.47,;20.03,-34.03,;21.36,-34.8,;22.72,-34.03,;22.72,-32.47,;24.06,-31.71,;24.06,-30.17,;25.39,-32.48,;26.73,-31.71,;27.92,-30.44,;29.25,-30.93,;30.65,-30.58,;30.66,-29.05,;29.26,-28.47,;27.92,-28.95,;28.22,-29.7,;28.23,-31.29,;29.64,-31.86,;21.37,-31.69,;21.37,-30.15,)|
Show InChI InChI=1S/C24H28N2O3/c1-2-17-12-29-20-5-3-4-18-22(20)26(17)11-19(23(18)27)24(28)25-21-15-7-13-6-14(9-15)10-16(21)8-13/h3-5,11,13-17,21H,2,6-10,12H2,1H3,(H,25,28)
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13.2n/an/an/an/an/an/an/an/a



Universit£ di Ferrara

Curated by ChEMBL


Assay Description
Displacement of [3H]CP-55940 from human recombinant CB2 receptor expressed in CHO cell membranes incubated for 60 mins by scintillation counting


J Med Chem 55: 6608-23 (2012)


Article DOI: 10.1021/jm300763w
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))
BDBM50395162
PNG
(CHEMBL2163935)
Show SMILES CCCC1COc2cccc3c2n1cc(C(=O)NC1CCCCC1)c3=O
Show InChI InChI=1S/C21H26N2O3/c1-2-7-15-13-26-18-11-6-10-16-19(18)23(15)12-17(20(16)24)21(25)22-14-8-4-3-5-9-14/h6,10-12,14-15H,2-5,7-9,13H2,1H3,(H,22,25)
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13.4n/an/an/an/an/an/an/an/a



Universit£ di Ferrara

Curated by ChEMBL


Assay Description
Displacement of [3H]CP-55940 from CB1 receptor in Sprague-Dawley rat brain by scintillation counting


J Med Chem 55: 6608-23 (2012)


Article DOI: 10.1021/jm300763w
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))
BDBM50350156
PNG
(CHEMBL1814463)
Show SMILES CCC1COc2cccc3c2n1cc(C(=O)NC12CC4CC(CC(C4)C1)C2)c3=O |TLB:16:17:20.19.24:22,THB:18:19:22:26.17.25,18:17:20.19.24:22,25:17:20:24.23.22,25:23:20:26.18.17|
Show InChI InChI=1S/C24H28N2O3/c1-2-17-13-29-20-5-3-4-18-21(20)26(17)12-19(22(18)27)23(28)25-24-9-14-6-15(10-24)8-16(7-14)11-24/h3-5,12,14-17H,2,6-11,13H2,1H3,(H,25,28)
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13.5n/an/an/an/an/an/an/an/a



Universit£ di Ferrara

Curated by ChEMBL


Assay Description
Displacement of [3H]CP-55940 from CB2 receptor in Sprague-Dawley rat spleen by scintillation counting


J Med Chem 55: 6608-23 (2012)


Article DOI: 10.1021/jm300763w
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50395177
PNG
(CHEMBL2163951)
Show SMILES O=C(NC12CC3CC(CC(C3)C1)C2)c1cn2C(COc3cccc(c23)c1=O)c1ccccc1 |THB:8:7:4:10.9.11,8:9:6.7.12:4,2:3:6:10.8.9,11:9:6:12.3.4,11:3:6:10.8.9|
Show InChI InChI=1S/C28H28N2O3/c31-26-21-7-4-8-24-25(21)30(23(16-33-24)20-5-2-1-3-6-20)15-22(26)27(32)29-28-12-17-9-18(13-28)11-19(10-17)14-28/h1-8,15,17-19,23H,9-14,16H2,(H,29,32)
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14.2n/an/an/an/an/an/an/an/a



Universit£ di Ferrara

Curated by ChEMBL


Assay Description
Displacement of [3H]CP-55940 from human recombinant CB2 receptor expressed in CHO cell membranes incubated for 60 mins by scintillation counting


J Med Chem 55: 6608-23 (2012)


Article DOI: 10.1021/jm300763w
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))
BDBM50395178
PNG
(CHEMBL2163950)
Show SMILES O=C(NC1CCCCCC1)c1cn2C(COc3cccc(c23)c1=O)c1ccccc1
Show InChI InChI=1S/C25H26N2O3/c28-24-19-13-8-14-22-23(19)27(21(16-30-22)17-9-4-3-5-10-17)15-20(24)25(29)26-18-11-6-1-2-7-12-18/h3-5,8-10,13-15,18,21H,1-2,6-7,11-12,16H2,(H,26,29)
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14.7n/an/an/an/an/an/an/an/a



Universit£ di Ferrara

Curated by ChEMBL


Assay Description
Displacement of [3H]CP-55940 from CB2 receptor in Sprague-Dawley rat spleen by scintillation counting


J Med Chem 55: 6608-23 (2012)


Article DOI: 10.1021/jm300763w
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50395157
PNG
(CHEMBL2163941)
Show SMILES O=C(NC1CCCCC1)c1cn2C(COc3cccc(c23)c1=O)C1CC1
Show InChI InChI=1S/C21H24N2O3/c24-20-15-7-4-8-18-19(15)23(17(12-26-18)13-9-10-13)11-16(20)21(25)22-14-5-2-1-3-6-14/h4,7-8,11,13-14,17H,1-3,5-6,9-10,12H2,(H,22,25)
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15.3n/an/an/an/an/an/an/an/a



Universit£ di Ferrara

Curated by ChEMBL


Assay Description
Displacement of [3H]CP-55940 from human recombinant CB2 receptor expressed in CHO cell membranes incubated for 60 mins by scintillation counting


J Med Chem 55: 6608-23 (2012)


Article DOI: 10.1021/jm300763w
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))
BDBM21281
PNG
((11R)-2-methyl-11-(morpholin-4-ylmethyl)-3-(naphth...)
Show SMILES Cc1c(C(=O)c2cccc3ccccc23)c2cccc3OC[C@@H](CN4CCOCC4)n1c23 |r|
Show InChI InChI=1S/C27H26N2O3/c1-18-25(27(30)22-9-4-7-19-6-2-3-8-21(19)22)23-10-5-11-24-26(23)29(18)20(17-32-24)16-28-12-14-31-15-13-28/h2-11,20H,12-17H2,1H3/t20-/m1/s1
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15.6n/an/an/an/an/an/an/an/a



Universit£ di Ferrara

Curated by ChEMBL


Assay Description
Displacement of [3H]CP-55940 from CB1 receptor in Sprague-Dawley rat brain by scintillation counting


J Med Chem 55: 6608-23 (2012)


Article DOI: 10.1021/jm300763w
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50395166
PNG
(CHEMBL2163931)
Show SMILES CCC1COc2cccc3c2n1cc(C(=O)NC(C)CCC(C)C)c3=O
Show InChI InChI=1S/C21H28N2O3/c1-5-15-12-26-18-8-6-7-16-19(18)23(15)11-17(20(16)24)21(25)22-14(4)10-9-13(2)3/h6-8,11,13-15H,5,9-10,12H2,1-4H3,(H,22,25)
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15.8n/an/an/an/an/an/an/an/a



Universit£ di Ferrara

Curated by ChEMBL


Assay Description
Displacement of [3H]CP-55940 from human recombinant CB2 receptor expressed in CHO cell membranes incubated for 60 mins by scintillation counting


J Med Chem 55: 6608-23 (2012)


Article DOI: 10.1021/jm300763w
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))
BDBM50395167
PNG
(CHEMBL2163930)
Show SMILES CCC1COc2cccc3c2n1cc(C(=O)NC1C2CC4CC(C2)CC1C4)c3=O |TLB:26:25:23:19.20.21,THB:26:20:17.25.24:23,16:17:23:19.20.21,21:20:17:24.22.23,21:22:17:19.26.20,(22.66,-38.66,;22.67,-37.12,;21.34,-36.34,;20.01,-37.1,;18.68,-36.32,;18.69,-34.79,;17.36,-34.02,;17.36,-32.48,;18.69,-31.71,;20.03,-32.47,;20.03,-34.03,;21.36,-34.8,;22.72,-34.03,;22.72,-32.47,;24.06,-31.71,;24.06,-30.17,;25.39,-32.48,;26.73,-31.71,;27.92,-30.44,;29.25,-30.93,;30.65,-30.58,;30.66,-29.05,;29.26,-28.47,;27.92,-28.95,;28.22,-29.7,;28.23,-31.29,;29.64,-31.86,;21.37,-31.69,;21.37,-30.15,)|
Show InChI InChI=1S/C24H28N2O3/c1-2-17-12-29-20-5-3-4-18-22(20)26(17)11-19(23(18)27)24(28)25-21-15-7-13-6-14(9-15)10-16(21)8-13/h3-5,11,13-17,21H,2,6-10,12H2,1H3,(H,25,28)
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16.1n/an/an/an/an/an/an/an/a



Universit£ di Ferrara

Curated by ChEMBL


Assay Description
Displacement of [3H]CP-55940 from CB2 receptor in Sprague-Dawley rat spleen by scintillation counting


J Med Chem 55: 6608-23 (2012)


Article DOI: 10.1021/jm300763w
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50395139
PNG
(CHEMBL2163927)
Show SMILES CC(C)[C@H]1COc2cccc3c2n1cc(C(=O)NC12CC4CC(CC(C4)C1)C2)c3=O |r,THB:23:22:19:25.24.26,23:24:21.22.27:19,26:24:21:27.18.19,26:18:21:25.23.24|
Show InChI InChI=1S/C25H30N2O3/c1-14(2)20-13-30-21-5-3-4-18-22(21)27(20)12-19(23(18)28)24(29)26-25-9-15-6-16(10-25)8-17(7-15)11-25/h3-5,12,14-17,20H,6-11,13H2,1-2H3,(H,26,29)/t15?,16?,17?,20-,25?/m1/s1
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16.2n/an/an/an/an/an/an/an/a



Universit£ di Ferrara

Curated by ChEMBL


Assay Description
Displacement of [3H]CP-55940 from human recombinant CB2 receptor expressed in CHO cell membranes incubated for 60 mins by scintillation counting


J Med Chem 55: 6608-23 (2012)


Article DOI: 10.1021/jm300763w
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 250 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%