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PubMed code 22877629

Compile data set for download or QSAR
Found 42 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Casein kinase I


(Homo sapiens (Human))
BDBM50390500
PNG
(CHEMBL2071614)
Show SMILES CC(C)(O)c1ccc(Nc2nc3ccc(cc3[nH]2)C#N)cc1
Show InChI InChI=1S/C17H16N4O/c1-17(2,22)12-4-6-13(7-5-12)19-16-20-14-8-3-11(10-18)9-15(14)21-16/h3-9,22H,1-2H3,(H2,19,20,21)
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n/an/a 700n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CK1gamma2 expressed in HEK293 cells assessed as inhibition of LRP6 Thr1479 phosphorylation by immunoblotting


Bioorg Med Chem Lett 22: 5392-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.046
More data for this
Ligand-Target Pair
Casein kinase I isoform delta


(Homo sapiens (Human))
BDBM50390497
PNG
(CHEMBL2071611)
Show SMILES Cn1cc(cn1)-c1ccc(Nc2nc3ccc(cc3[nH]2)C#N)cc1
Show InChI InChI=1S/C18H14N6/c1-24-11-14(10-20-24)13-3-5-15(6-4-13)21-18-22-16-7-2-12(9-19)8-17(16)23-18/h2-8,10-11H,1H3,(H2,21,22,23)
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n/an/a 1.08E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CK1delta by Lance assay


Bioorg Med Chem Lett 22: 5392-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.046
More data for this
Ligand-Target Pair
Casein kinase I


(Homo sapiens (Human))
BDBM50390496
PNG
(CHEMBL2071610)
Show SMILES Fc1ncccc1-c1ccc(Nc2nc3ccc(cc3[nH]2)C#N)cc1
Show InChI InChI=1S/C19H12FN5/c20-18-15(2-1-9-22-18)13-4-6-14(7-5-13)23-19-24-16-8-3-12(11-21)10-17(16)25-19/h1-10H,(H2,23,24,25)
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n/an/a 1.17E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CK1gamma2 expressed in HEK293 cells assessed as inhibition of LRP6 Thr1479 phosphorylation by immunoblotting


Bioorg Med Chem Lett 22: 5392-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.046
More data for this
Ligand-Target Pair
Casein kinase I


(Homo sapiens (Human))
BDBM50390497
PNG
(CHEMBL2071611)
Show SMILES Cn1cc(cn1)-c1ccc(Nc2nc3ccc(cc3[nH]2)C#N)cc1
Show InChI InChI=1S/C18H14N6/c1-24-11-14(10-20-24)13-3-5-15(6-4-13)21-18-22-16-7-2-12(9-19)8-17(16)23-18/h2-8,10-11H,1H3,(H2,21,22,23)
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n/an/a 1.45E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CK1gamma2 expressed in HEK293 cells assessed as inhibition of LRP6 Thr1479 phosphorylation by immunoblotting


Bioorg Med Chem Lett 22: 5392-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.046
More data for this
Ligand-Target Pair
Casein kinase I


(Homo sapiens (Human))
BDBM50390498
PNG
(CHEMBL2071612)
Show SMILES CC(C)(C)c1ccc(Nc2nc3ccc(cc3[nH]2)C#N)cc1
Show InChI InChI=1S/C18H18N4/c1-18(2,3)13-5-7-14(8-6-13)20-17-21-15-9-4-12(11-19)10-16(15)22-17/h4-10H,1-3H3,(H2,20,21,22)
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n/an/a 1.51E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CK1gamma2 expressed in HEK293 cells assessed as inhibition of LRP6 Thr1479 phosphorylation by immunoblotting


Bioorg Med Chem Lett 22: 5392-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.046
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Casein kinase I isoform delta


(Homo sapiens (Human))
BDBM50390496
PNG
(CHEMBL2071610)
Show SMILES Fc1ncccc1-c1ccc(Nc2nc3ccc(cc3[nH]2)C#N)cc1
Show InChI InChI=1S/C19H12FN5/c20-18-15(2-1-9-22-18)13-4-6-14(7-5-13)23-19-24-16-8-3-12(11-21)10-17(16)25-19/h1-10H,(H2,23,24,25)
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n/an/a 1.63E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CK1delta by Lance assay


Bioorg Med Chem Lett 22: 5392-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.046
More data for this
Ligand-Target Pair
Casein kinase I isoform delta


(Homo sapiens (Human))
BDBM50390506
PNG
(CHEMBL2071624)
Show SMILES CC(C)(C)c1ccc(Nc2nc3ccc(cc3s2)C#N)cc1
Show InChI InChI=1S/C18H17N3S/c1-18(2,3)13-5-7-14(8-6-13)20-17-21-15-9-4-12(11-19)10-16(15)22-17/h4-10H,1-3H3,(H,20,21)
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n/an/a 1.66E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CK1delta by Lance assay


Bioorg Med Chem Lett 22: 5392-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.046
More data for this
Ligand-Target Pair
Casein kinase I isoform delta


(Homo sapiens (Human))
BDBM50390501
PNG
(CHEMBL2071615)
Show SMILES CC(C)(C)c1ccc(Nc2nc3ccc(cc3[nH]2)C#N)c(F)c1
Show InChI InChI=1S/C18H17FN4/c1-18(2,3)12-5-7-14(13(19)9-12)21-17-22-15-6-4-11(10-20)8-16(15)23-17/h4-9H,1-3H3,(H2,21,22,23)
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n/an/a 2.18E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CK1delta by Lance assay


Bioorg Med Chem Lett 22: 5392-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.046
More data for this
Ligand-Target Pair
Casein kinase I isoform delta


(Homo sapiens (Human))
BDBM50390495
PNG
(CHEMBL2071609)
Show SMILES N#Cc1ccc2nc(Nc3ccc(cc3)-c3ccccc3)[nH]c2c1
Show InChI InChI=1S/C20H14N4/c21-13-14-6-11-18-19(12-14)24-20(23-18)22-17-9-7-16(8-10-17)15-4-2-1-3-5-15/h1-12H,(H2,22,23,24)
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n/an/a 2.18E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CK1delta by Lance assay


Bioorg Med Chem Lett 22: 5392-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.046
More data for this
Ligand-Target Pair
Casein kinase I isoform delta


(Homo sapiens (Human))
BDBM50390500
PNG
(CHEMBL2071614)
Show SMILES CC(C)(O)c1ccc(Nc2nc3ccc(cc3[nH]2)C#N)cc1
Show InChI InChI=1S/C17H16N4O/c1-17(2,22)12-4-6-13(7-5-12)19-16-20-14-8-3-11(10-18)9-15(14)21-16/h3-9,22H,1-2H3,(H2,19,20,21)
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n/an/a 2.32E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CK1delta by Lance assay


Bioorg Med Chem Lett 22: 5392-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.046
More data for this
Ligand-Target Pair
Casein kinase I


(Homo sapiens (Human))
BDBM50390503
PNG
(CHEMBL2071618)
Show SMILES CC(C)(C)c1ccc(Nc2nc3ccc(cc3[nH]2)[N+]([O-])=O)cc1
Show InChI InChI=1S/C17H18N4O2/c1-17(2,3)11-4-6-12(7-5-11)18-16-19-14-9-8-13(21(22)23)10-15(14)20-16/h4-10H,1-3H3,(H2,18,19,20)
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n/an/a 2.34E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CK1gamma2 expressed in HEK293 cells assessed as inhibition of LRP6 Thr1479 phosphorylation by immunoblotting


Bioorg Med Chem Lett 22: 5392-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.046
More data for this
Ligand-Target Pair
Casein kinase I isoform delta


(Homo sapiens (Human))
BDBM50390505
PNG
(CHEMBL2071623)
Show SMILES CC(C)(C)c1ccc(Nc2nc3ccc(cc3o2)C#N)cc1
Show InChI InChI=1S/C18H17N3O/c1-18(2,3)13-5-7-14(8-6-13)20-17-21-15-9-4-12(11-19)10-16(15)22-17/h4-10H,1-3H3,(H,20,21)
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n/an/a 2.37E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CK1delta by Lance assay


Bioorg Med Chem Lett 22: 5392-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.046
More data for this
Ligand-Target Pair
Casein kinase I isoform delta


(Homo sapiens (Human))
BDBM50390498
PNG
(CHEMBL2071612)
Show SMILES CC(C)(C)c1ccc(Nc2nc3ccc(cc3[nH]2)C#N)cc1
Show InChI InChI=1S/C18H18N4/c1-18(2,3)13-5-7-14(8-6-13)20-17-21-15-9-4-12(11-19)10-16(15)22-17/h4-10H,1-3H3,(H2,20,21,22)
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n/an/a 2.62E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CK1delta by Lance assay


Bioorg Med Chem Lett 22: 5392-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.046
More data for this
Ligand-Target Pair
Casein kinase I isoform delta


(Homo sapiens (Human))
BDBM50390503
PNG
(CHEMBL2071618)
Show SMILES CC(C)(C)c1ccc(Nc2nc3ccc(cc3[nH]2)[N+]([O-])=O)cc1
Show InChI InChI=1S/C17H18N4O2/c1-17(2,3)11-4-6-12(7-5-11)18-16-19-14-9-8-13(21(22)23)10-15(14)20-16/h4-10H,1-3H3,(H2,18,19,20)
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n/an/a 2.88E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CK1delta by Lance assay


Bioorg Med Chem Lett 22: 5392-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.046
More data for this
Ligand-Target Pair
Casein kinase I isoform delta


(Homo sapiens (Human))
BDBM50390494
PNG
(CHEMBL2071608)
Show SMILES N#Cc1ccc2nc(Nc3ccc(Oc4ccccc4)cc3)[nH]c2c1
Show InChI InChI=1S/C20H14N4O/c21-13-14-6-11-18-19(12-14)24-20(23-18)22-15-7-9-17(10-8-15)25-16-4-2-1-3-5-16/h1-12H,(H2,22,23,24)
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n/an/a 3.17E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CK1delta by Lance assay


Bioorg Med Chem Lett 22: 5392-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.046
More data for this
Ligand-Target Pair
Casein kinase I isoform delta


(Homo sapiens (Human))
BDBM50390507
PNG
(CHEMBL2071625)
Show SMILES CC(C)(C)c1ccc(Nc2cn3cc(ccc3n2)C#N)cc1
Show InChI InChI=1S/C18H18N4/c1-18(2,3)14-5-7-15(8-6-14)20-16-12-22-11-13(10-19)4-9-17(22)21-16/h4-9,11-12,20H,1-3H3
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n/an/a 3.17E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CK1delta by Lance assay


Bioorg Med Chem Lett 22: 5392-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.046
More data for this
Ligand-Target Pair
Casein kinase I isoform alpha


(Homo sapiens (Human))
BDBM50390497
PNG
(CHEMBL2071611)
Show SMILES Cn1cc(cn1)-c1ccc(Nc2nc3ccc(cc3[nH]2)C#N)cc1
Show InChI InChI=1S/C18H14N6/c1-24-11-14(10-20-24)13-3-5-15(6-4-13)21-18-22-16-7-2-12(9-19)8-17(16)23-18/h2-8,10-11H,1H3,(H2,21,22,23)
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n/an/a 3.54E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CK1alpha by Lance assay


Bioorg Med Chem Lett 22: 5392-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.046
More data for this
Ligand-Target Pair
Casein kinase I isoform delta


(Homo sapiens (Human))
BDBM50390499
PNG
(CHEMBL2071613)
Show SMILES Cc1ccc(Nc2nc3ccc(cc3[nH]2)C#N)cc1
Show InChI InChI=1S/C15H12N4/c1-10-2-5-12(6-3-10)17-15-18-13-7-4-11(9-16)8-14(13)19-15/h2-8H,1H3,(H2,17,18,19)
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n/an/a 3.61E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CK1delta by Lance assay


Bioorg Med Chem Lett 22: 5392-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.046
More data for this
Ligand-Target Pair
Casein kinase I


(Homo sapiens (Human))
BDBM50390506
PNG
(CHEMBL2071624)
Show SMILES CC(C)(C)c1ccc(Nc2nc3ccc(cc3s2)C#N)cc1
Show InChI InChI=1S/C18H17N3S/c1-18(2,3)13-5-7-14(8-6-13)20-17-21-15-9-4-12(11-19)10-16(15)22-17/h4-10H,1-3H3,(H,20,21)
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n/an/a 3.83E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CK1gamma2 expressed in HEK293 cells assessed as inhibition of LRP6 Thr1479 phosphorylation by immunoblotting


Bioorg Med Chem Lett 22: 5392-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.046
More data for this
Ligand-Target Pair
Casein kinase I isoform delta


(Homo sapiens (Human))
BDBM50390504
PNG
(CHEMBL2071622)
Show SMILES Cc1cc2nc(Nc3ccc(cc3)C(C)(C)C)[nH]c2cc1C#N
Show InChI InChI=1S/C19H20N4/c1-12-9-16-17(10-13(12)11-20)23-18(22-16)21-15-7-5-14(6-8-15)19(2,3)4/h5-10H,1-4H3,(H2,21,22,23)
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n/an/a 3.97E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CK1delta by Lance assay


Bioorg Med Chem Lett 22: 5392-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.046
More data for this
Ligand-Target Pair
Casein kinase I isoform delta


(Homo sapiens (Human))
BDBM50390502
PNG
(CHEMBL2071616)
Show SMILES Cc1cc(ccc1Nc1nc2ccc(cc2[nH]1)C#N)C(C)(C)C
Show InChI InChI=1S/C19H20N4/c1-12-9-14(19(2,3)4)6-8-15(12)21-18-22-16-7-5-13(11-20)10-17(16)23-18/h5-10H,1-4H3,(H2,21,22,23)
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n/an/a 4.37E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CK1delta by Lance assay


Bioorg Med Chem Lett 22: 5392-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.046
More data for this
Ligand-Target Pair
Casein kinase I


(Homo sapiens (Human))
BDBM50390499
PNG
(CHEMBL2071613)
Show SMILES Cc1ccc(Nc2nc3ccc(cc3[nH]2)C#N)cc1
Show InChI InChI=1S/C15H12N4/c1-10-2-5-12(6-3-10)17-15-18-13-7-4-11(9-16)8-14(13)19-15/h2-8H,1H3,(H2,17,18,19)
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n/an/a 4.54E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CK1gamma2 expressed in HEK293 cells assessed as inhibition of LRP6 Thr1479 phosphorylation by immunoblotting


Bioorg Med Chem Lett 22: 5392-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.046
More data for this
Ligand-Target Pair
Casein kinase I isoform alpha


(Homo sapiens (Human))
BDBM50390496
PNG
(CHEMBL2071610)
Show SMILES Fc1ncccc1-c1ccc(Nc2nc3ccc(cc3[nH]2)C#N)cc1
Show InChI InChI=1S/C19H12FN5/c20-18-15(2-1-9-22-18)13-4-6-14(7-5-13)23-19-24-16-8-3-12(11-21)10-17(16)25-19/h1-10H,(H2,23,24,25)
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n/an/a 4.67E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CK1alpha by Lance assay


Bioorg Med Chem Lett 22: 5392-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.046
More data for this
Ligand-Target Pair
Casein kinase I


(Homo sapiens (Human))
BDBM50390495
PNG
(CHEMBL2071609)
Show SMILES N#Cc1ccc2nc(Nc3ccc(cc3)-c3ccccc3)[nH]c2c1
Show InChI InChI=1S/C20H14N4/c21-13-14-6-11-18-19(12-14)24-20(23-18)22-17-9-7-16(8-10-17)15-4-2-1-3-5-15/h1-12H,(H2,22,23,24)
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n/an/a 4.89E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CK1gamma2 expressed in HEK293 cells assessed as inhibition of LRP6 Thr1479 phosphorylation by immunoblotting


Bioorg Med Chem Lett 22: 5392-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.046
More data for this
Ligand-Target Pair
Casein kinase I isoform alpha


(Homo sapiens (Human))
BDBM50390495
PNG
(CHEMBL2071609)
Show SMILES N#Cc1ccc2nc(Nc3ccc(cc3)-c3ccccc3)[nH]c2c1
Show InChI InChI=1S/C20H14N4/c21-13-14-6-11-18-19(12-14)24-20(23-18)22-17-9-7-16(8-10-17)15-4-2-1-3-5-15/h1-12H,(H2,22,23,24)
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n/an/a 5.49E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CK1alpha by Lance assay


Bioorg Med Chem Lett 22: 5392-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.046
More data for this
Ligand-Target Pair
Casein kinase I isoform delta


(Homo sapiens (Human))
BDBM124350
PNG
(CHEMBL2071607 | US8759532, 1)
Show SMILES FC(F)(F)c1cccnc1Oc1ccc(Nc2nc3ccc(cc3[nH]2)C#N)cc1
Show InChI InChI=1S/C20H12F3N5O/c21-20(22,23)15-2-1-9-25-18(15)29-14-6-4-13(5-7-14)26-19-27-16-8-3-12(11-24)10-17(16)28-19/h1-10H,(H2,26,27,28)
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n/an/a 5.77E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CK1delta by Lance assay


Bioorg Med Chem Lett 22: 5392-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.046
More data for this
Ligand-Target Pair
Casein kinase I


(Homo sapiens (Human))
BDBM124350
PNG
(CHEMBL2071607 | US8759532, 1)
Show SMILES FC(F)(F)c1cccnc1Oc1ccc(Nc2nc3ccc(cc3[nH]2)C#N)cc1
Show InChI InChI=1S/C20H12F3N5O/c21-20(22,23)15-2-1-9-25-18(15)29-14-6-4-13(5-7-14)26-19-27-16-8-3-12(11-24)10-17(16)28-19/h1-10H,(H2,26,27,28)
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n/an/a 6.56E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CK1gamma2 expressed in HEK293 cells assessed as inhibition of LRP6 Thr1479 phosphorylation by immunoblotting


Bioorg Med Chem Lett 22: 5392-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.046
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Casein kinase I isoform alpha


(Homo sapiens (Human))
BDBM50390498
PNG
(CHEMBL2071612)
Show SMILES CC(C)(C)c1ccc(Nc2nc3ccc(cc3[nH]2)C#N)cc1
Show InChI InChI=1S/C18H18N4/c1-18(2,3)13-5-7-14(8-6-13)20-17-21-15-9-4-12(11-19)10-16(15)22-17/h4-10H,1-3H3,(H2,20,21,22)
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n/an/a 7.58E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CK1alpha by Lance assay


Bioorg Med Chem Lett 22: 5392-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.046
More data for this
Ligand-Target Pair
Casein kinase I isoform alpha


(Homo sapiens (Human))
BDBM50390494
PNG
(CHEMBL2071608)
Show SMILES N#Cc1ccc2nc(Nc3ccc(Oc4ccccc4)cc3)[nH]c2c1
Show InChI InChI=1S/C20H14N4O/c21-13-14-6-11-18-19(12-14)24-20(23-18)22-15-7-9-17(10-8-15)25-16-4-2-1-3-5-16/h1-12H,(H2,22,23,24)
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n/an/a 8.82E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CK1alpha by Lance assay


Bioorg Med Chem Lett 22: 5392-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.046
More data for this
Ligand-Target Pair
Casein kinase I


(Homo sapiens (Human))
BDBM50390507
PNG
(CHEMBL2071625)
Show SMILES CC(C)(C)c1ccc(Nc2cn3cc(ccc3n2)C#N)cc1
Show InChI InChI=1S/C18H18N4/c1-18(2,3)14-5-7-15(8-6-14)20-16-12-22-11-13(10-19)4-9-17(22)21-16/h4-9,11-12,20H,1-3H3
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n/an/a 9.10E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CK1gamma2 expressed in HEK293 cells assessed as inhibition of LRP6 Thr1479 phosphorylation by immunoblotting


Bioorg Med Chem Lett 22: 5392-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.046
More data for this
Ligand-Target Pair
Casein kinase I isoform alpha


(Homo sapiens (Human))
BDBM50390500
PNG
(CHEMBL2071614)
Show SMILES CC(C)(O)c1ccc(Nc2nc3ccc(cc3[nH]2)C#N)cc1
Show InChI InChI=1S/C17H16N4O/c1-17(2,22)12-4-6-13(7-5-12)19-16-20-14-8-3-11(10-18)9-15(14)21-16/h3-9,22H,1-2H3,(H2,19,20,21)
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n/an/a 9.18E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CK1alpha by Lance assay


Bioorg Med Chem Lett 22: 5392-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.046
More data for this
Ligand-Target Pair
Casein kinase I


(Homo sapiens (Human))
BDBM50390501
PNG
(CHEMBL2071615)
Show SMILES CC(C)(C)c1ccc(Nc2nc3ccc(cc3[nH]2)C#N)c(F)c1
Show InChI InChI=1S/C18H17FN4/c1-18(2,3)12-5-7-14(13(19)9-12)21-17-22-15-6-4-11(10-20)8-16(15)23-17/h4-9H,1-3H3,(H2,21,22,23)
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n/an/a 1.01E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CK1gamma2 expressed in HEK293 cells assessed as inhibition of LRP6 Thr1479 phosphorylation by immunoblotting


Bioorg Med Chem Lett 22: 5392-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.046
More data for this
Ligand-Target Pair
Casein kinase I isoform alpha


(Homo sapiens (Human))
BDBM124350
PNG
(CHEMBL2071607 | US8759532, 1)
Show SMILES FC(F)(F)c1cccnc1Oc1ccc(Nc2nc3ccc(cc3[nH]2)C#N)cc1
Show InChI InChI=1S/C20H12F3N5O/c21-20(22,23)15-2-1-9-25-18(15)29-14-6-4-13(5-7-14)26-19-27-16-8-3-12(11-24)10-17(16)28-19/h1-10H,(H2,26,27,28)
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n/an/a 1.21E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CK1alpha by Lance assay


Bioorg Med Chem Lett 22: 5392-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.046
More data for this
Ligand-Target Pair
Casein kinase I


(Homo sapiens (Human))
BDBM50390504
PNG
(CHEMBL2071622)
Show SMILES Cc1cc2nc(Nc3ccc(cc3)C(C)(C)C)[nH]c2cc1C#N
Show InChI InChI=1S/C19H20N4/c1-12-9-16-17(10-13(12)11-20)23-18(22-16)21-15-7-5-14(6-8-15)19(2,3)4/h5-10H,1-4H3,(H2,21,22,23)
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n/an/a 1.30E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CK1gamma2 expressed in HEK293 cells assessed as inhibition of LRP6 Thr1479 phosphorylation by immunoblotting


Bioorg Med Chem Lett 22: 5392-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.046
More data for this
Ligand-Target Pair
Casein kinase I


(Homo sapiens (Human))
BDBM50390505
PNG
(CHEMBL2071623)
Show SMILES CC(C)(C)c1ccc(Nc2nc3ccc(cc3o2)C#N)cc1
Show InChI InChI=1S/C18H17N3O/c1-18(2,3)13-5-7-14(8-6-13)20-17-21-15-9-4-12(11-19)10-16(15)22-17/h4-10H,1-3H3,(H,20,21)
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n/an/a 1.49E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CK1gamma2 expressed in HEK293 cells assessed as inhibition of LRP6 Thr1479 phosphorylation by immunoblotting


Bioorg Med Chem Lett 22: 5392-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.046
More data for this
Ligand-Target Pair
Casein kinase I isoform alpha


(Homo sapiens (Human))
BDBM50390499
PNG
(CHEMBL2071613)
Show SMILES Cc1ccc(Nc2nc3ccc(cc3[nH]2)C#N)cc1
Show InChI InChI=1S/C15H12N4/c1-10-2-5-12(6-3-10)17-15-18-13-7-4-11(9-16)8-14(13)19-15/h2-8H,1H3,(H2,17,18,19)
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n/an/a 1.97E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CK1alpha by Lance assay


Bioorg Med Chem Lett 22: 5392-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.046
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM50390496
PNG
(CHEMBL2071610)
Show SMILES Fc1ncccc1-c1ccc(Nc2nc3ccc(cc3[nH]2)C#N)cc1
Show InChI InChI=1S/C19H12FN5/c20-18-15(2-1-9-22-18)13-4-6-14(7-5-13)23-19-24-16-8-3-12(11-21)10-17(16)25-19/h1-10H,(H2,23,24,25)
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n/an/a 2.42E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of GSK3beta by AlphaScreen assay


Bioorg Med Chem Lett 22: 5392-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.046
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM50390499
PNG
(CHEMBL2071613)
Show SMILES Cc1ccc(Nc2nc3ccc(cc3[nH]2)C#N)cc1
Show InChI InChI=1S/C15H12N4/c1-10-2-5-12(6-3-10)17-15-18-13-7-4-11(9-16)8-14(13)19-15/h2-8H,1H3,(H2,17,18,19)
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n/an/a 3.01E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of GSK3beta by AlphaScreen assay


Bioorg Med Chem Lett 22: 5392-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.046
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM124350
PNG
(CHEMBL2071607 | US8759532, 1)
Show SMILES FC(F)(F)c1cccnc1Oc1ccc(Nc2nc3ccc(cc3[nH]2)C#N)cc1
Show InChI InChI=1S/C20H12F3N5O/c21-20(22,23)15-2-1-9-25-18(15)29-14-6-4-13(5-7-14)26-19-27-16-8-3-12(11-24)10-17(16)28-19/h1-10H,(H2,26,27,28)
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n/an/a 3.08E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of GSK3beta by AlphaScreen assay


Bioorg Med Chem Lett 22: 5392-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.046
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM50390495
PNG
(CHEMBL2071609)
Show SMILES N#Cc1ccc2nc(Nc3ccc(cc3)-c3ccccc3)[nH]c2c1
Show InChI InChI=1S/C20H14N4/c21-13-14-6-11-18-19(12-14)24-20(23-18)22-17-9-7-16(8-10-17)15-4-2-1-3-5-15/h1-12H,(H2,22,23,24)
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n/an/a 3.08E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of GSK3beta by AlphaScreen assay


Bioorg Med Chem Lett 22: 5392-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.046
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM50390498
PNG
(CHEMBL2071612)
Show SMILES CC(C)(C)c1ccc(Nc2nc3ccc(cc3[nH]2)C#N)cc1
Show InChI InChI=1S/C18H18N4/c1-18(2,3)13-5-7-14(8-6-13)20-17-21-15-9-4-12(11-19)10-16(15)22-17/h4-10H,1-3H3,(H2,20,21,22)
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n/an/a 4.45E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of GSK3beta by AlphaScreen assay


Bioorg Med Chem Lett 22: 5392-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.046
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM50390500
PNG
(CHEMBL2071614)
Show SMILES CC(C)(O)c1ccc(Nc2nc3ccc(cc3[nH]2)C#N)cc1
Show InChI InChI=1S/C17H16N4O/c1-17(2,22)12-4-6-13(7-5-12)19-16-20-14-8-3-11(10-18)9-15(14)21-16/h3-9,22H,1-2H3,(H2,19,20,21)
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n/an/a 6.00E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of GSK3beta by AlphaScreen assay


Bioorg Med Chem Lett 22: 5392-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.046
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%