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PubMed code 22944118

Compile data set for download or QSAR
Found 27 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM50397056
PNG
(CHEMBL2171440)
Show SMILES COc1cc(ccc1-c1nc2c(C)nn(C3CCCCC3)c(=O)c2[nH]1)C1CC1C(N)=O
Show InChI InChI=1S/C23H27N5O3/c1-12-19-20(23(30)28(27-12)14-6-4-3-5-7-14)26-22(25-19)15-9-8-13(10-18(15)31-2)16-11-17(16)21(24)29/h8-10,14,16-17H,3-7,11H2,1-2H3,(H2,24,29)(H,25,26)
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Glenmark Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibition of cloned human recombinant PDE7A assessed as [3H]cAMP hydrolysis by radiometric assay


Bioorg Med Chem Lett 22: 6286-91 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.077
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 7B


(Homo sapiens (Human))
BDBM50397053
PNG
(CHEMBL2171422)
Show SMILES COc1cc(ccc1-c1nc2c(C)nn(C3CCCCC3)c(=O)c2[nH]1)N1CCC(N)CC1
Show InChI InChI=1S/C24H32N6O2/c1-15-21-22(24(31)30(28-15)17-6-4-3-5-7-17)27-23(26-21)19-9-8-18(14-20(19)32-2)29-12-10-16(25)11-13-29/h8-9,14,16-17H,3-7,10-13,25H2,1-2H3,(H,26,27)
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Glenmark Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibition of cloned human recombinant PDE7B assessed as [3H]cAMP hydrolysis by radiometric assay


Bioorg Med Chem Lett 22: 6286-91 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.077
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM50397052
PNG
(CHEMBL2171423)
Show SMILES COc1cc(ccc1-c1nc2c(C)nn(C3CCCCC3)c(=O)c2[nH]1)N1CCCNCC1
Show InChI InChI=1S/C24H32N6O2/c1-16-21-22(24(31)30(28-16)17-7-4-3-5-8-17)27-23(26-21)19-10-9-18(15-20(19)32-2)29-13-6-11-25-12-14-29/h9-10,15,17,25H,3-8,11-14H2,1-2H3,(H,26,27)
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Glenmark Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibition of cloned human recombinant PDE7A assessed as [3H]cAMP hydrolysis by radiometric assay


Bioorg Med Chem Lett 22: 6286-91 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.077
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM50397061
PNG
(CHEMBL2171435)
Show SMILES COc1cc(ccc1-c1nc2c(C)nn(C3CCCCC3)c(=O)c2[nH]1)N1CCNC(=O)C1
Show InChI InChI=1S/C23H28N6O3/c1-14-20-21(23(31)29(27-14)15-6-4-3-5-7-15)26-22(25-20)17-9-8-16(12-18(17)32-2)28-11-10-24-19(30)13-28/h8-9,12,15H,3-7,10-11,13H2,1-2H3,(H,24,30)(H,25,26)
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Glenmark Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibition of cloned human recombinant PDE7A assessed as [3H]cAMP hydrolysis by radiometric assay


Bioorg Med Chem Lett 22: 6286-91 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.077
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 7B


(Homo sapiens (Human))
BDBM50397052
PNG
(CHEMBL2171423)
Show SMILES COc1cc(ccc1-c1nc2c(C)nn(C3CCCCC3)c(=O)c2[nH]1)N1CCCNCC1
Show InChI InChI=1S/C24H32N6O2/c1-16-21-22(24(31)30(28-16)17-7-4-3-5-8-17)27-23(26-21)19-10-9-18(15-20(19)32-2)29-13-6-11-25-12-14-29/h9-10,15,17,25H,3-8,11-14H2,1-2H3,(H,26,27)
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n/an/a 19n/an/an/an/an/an/a



Glenmark Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibition of cloned human recombinant PDE7B assessed as [3H]cAMP hydrolysis by radiometric assay


Bioorg Med Chem Lett 22: 6286-91 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.077
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM50397060
PNG
(CHEMBL2171436)
Show SMILES CNC(=O)Nc1ccc(-c2nc3c(C)nn(C4CCCCC4)c(=O)c3[nH]2)c(OC)c1
Show InChI InChI=1S/C21H26N6O3/c1-12-17-18(20(28)27(26-12)14-7-5-4-6-8-14)25-19(24-17)15-10-9-13(11-16(15)30-3)23-21(29)22-2/h9-11,14H,4-8H2,1-3H3,(H,24,25)(H2,22,23,29)
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Glenmark Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibition of cloned human recombinant PDE7A assessed as [3H]cAMP hydrolysis by radiometric assay


Bioorg Med Chem Lett 22: 6286-91 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.077
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM50397053
PNG
(CHEMBL2171422)
Show SMILES COc1cc(ccc1-c1nc2c(C)nn(C3CCCCC3)c(=O)c2[nH]1)N1CCC(N)CC1
Show InChI InChI=1S/C24H32N6O2/c1-15-21-22(24(31)30(28-15)17-6-4-3-5-7-17)27-23(26-21)19-9-8-18(14-20(19)32-2)29-12-10-16(25)11-13-29/h8-9,14,16-17H,3-7,10-13,25H2,1-2H3,(H,26,27)
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n/an/a 27n/an/an/an/an/an/a



Glenmark Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibition of cloned human recombinant PDE7A assessed as [3H]cAMP hydrolysis by radiometric assay


Bioorg Med Chem Lett 22: 6286-91 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.077
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM50397054
PNG
(CHEMBL2171421)
Show SMILES COc1cc(N)ccc1-c1nc2c(C)nn(C3CCCCC3)c(=O)c2[nH]1
Show InChI InChI=1S/C19H23N5O2/c1-11-16-17(19(25)24(23-11)13-6-4-3-5-7-13)22-18(21-16)14-9-8-12(20)10-15(14)26-2/h8-10,13H,3-7,20H2,1-2H3,(H,21,22)
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Glenmark Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibition of cloned human recombinant PDE7A assessed as [3H]cAMP hydrolysis by radiometric assay


Bioorg Med Chem Lett 22: 6286-91 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.077
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM50397062
PNG
(CHEMBL2171434)
Show SMILES COc1cc(ccc1-c1nc2c(C)nn(C3CCCCC3)c(=O)c2[nH]1)N1CCCN(CC1)C(C)=O
Show InChI InChI=1S/C26H34N6O3/c1-17-23-24(26(34)32(29-17)19-8-5-4-6-9-19)28-25(27-23)21-11-10-20(16-22(21)35-3)31-13-7-12-30(14-15-31)18(2)33/h10-11,16,19H,4-9,12-15H2,1-3H3,(H,27,28)
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Glenmark Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibition of cloned human recombinant PDE7A assessed as [3H]cAMP hydrolysis by radiometric assay


Bioorg Med Chem Lett 22: 6286-91 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.077
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM50397063
PNG
(CHEMBL2171433)
Show SMILES COc1cc(ccc1-c1nc2c(C)nn(C3CCCCC3)c(=O)c2[nH]1)N1CCCC(O)CC1
Show InChI InChI=1S/C25H33N5O3/c1-16-22-23(25(32)30(28-16)17-7-4-3-5-8-17)27-24(26-22)20-11-10-18(15-21(20)33-2)29-13-6-9-19(31)12-14-29/h10-11,15,17,19,31H,3-9,12-14H2,1-2H3,(H,26,27)
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Glenmark Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibition of cloned human recombinant PDE7A assessed as [3H]cAMP hydrolysis by radiometric assay


Bioorg Med Chem Lett 22: 6286-91 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.077
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 7B


(Homo sapiens (Human))
BDBM50397054
PNG
(CHEMBL2171421)
Show SMILES COc1cc(N)ccc1-c1nc2c(C)nn(C3CCCCC3)c(=O)c2[nH]1
Show InChI InChI=1S/C19H23N5O2/c1-11-16-17(19(25)24(23-11)13-6-4-3-5-7-13)22-18(21-16)14-9-8-12(20)10-15(14)26-2/h8-10,13H,3-7,20H2,1-2H3,(H,21,22)
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n/an/a 43n/an/an/an/an/an/a



Glenmark Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibition of cloned human recombinant PDE7B assessed as [3H]cAMP hydrolysis by radiometric assay


Bioorg Med Chem Lett 22: 6286-91 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.077
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM50397067
PNG
(CHEMBL2171429)
Show SMILES COc1cc(ccc1-c1nc2c(C)nn(C3CCCCC3)c(=O)c2[nH]1)-c1cn[nH]c1
Show InChI InChI=1S/C22H24N6O2/c1-13-19-20(22(29)28(27-13)16-6-4-3-5-7-16)26-21(25-19)17-9-8-14(10-18(17)30-2)15-11-23-24-12-15/h8-12,16H,3-7H2,1-2H3,(H,23,24)(H,25,26)
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Glenmark Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibition of cloned human recombinant PDE7A assessed as [3H]cAMP hydrolysis by radiometric assay


Bioorg Med Chem Lett 22: 6286-91 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.077
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM50397066
PNG
(CHEMBL2171430)
Show SMILES COc1cc(ccc1-c1nc2c(C)nn(C3CCCCC3)c(=O)c2[nH]1)N1CC(O)C1
Show InChI InChI=1S/C22H27N5O3/c1-13-19-20(22(29)27(25-13)14-6-4-3-5-7-14)24-21(23-19)17-9-8-15(10-18(17)30-2)26-11-16(28)12-26/h8-10,14,16,28H,3-7,11-12H2,1-2H3,(H,23,24)
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Glenmark Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibition of cloned human recombinant PDE7A assessed as [3H]cAMP hydrolysis by radiometric assay


Bioorg Med Chem Lett 22: 6286-91 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.077
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM50397068
PNG
(CHEMBL2171428)
Show SMILES COc1cc(O[C@@H]2CCNC2)ccc1-c1nc2c(C)nn(C3CCCCC3)c(=O)c2[nH]1 |r|
Show InChI InChI=1S/C23H29N5O3/c1-14-20-21(23(29)28(27-14)15-6-4-3-5-7-15)26-22(25-20)18-9-8-16(12-19(18)30-2)31-17-10-11-24-13-17/h8-9,12,15,17,24H,3-7,10-11,13H2,1-2H3,(H,25,26)/t17-/m1/s1
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Glenmark Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibition of cloned human recombinant PDE7A assessed as [3H]cAMP hydrolysis by radiometric assay


Bioorg Med Chem Lett 22: 6286-91 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.077
More data for this
Ligand-Target Pair
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A


(Mus musculus)
BDBM50397054
PNG
(CHEMBL2171421)
Show SMILES COc1cc(N)ccc1-c1nc2c(C)nn(C3CCCCC3)c(=O)c2[nH]1
Show InChI InChI=1S/C19H23N5O2/c1-11-16-17(19(25)24(23-11)13-6-4-3-5-7-13)22-18(21-16)14-9-8-12(20)10-15(14)26-2/h8-10,13H,3-7,20H2,1-2H3,(H,21,22)
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Glenmark Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibition of mouse PDE7A assessed as [3H]cAMP hydrolysis after 5 to 15 mins by scintillation counter


Bioorg Med Chem Lett 22: 6286-91 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.077
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM50397059
PNG
(CHEMBL2171437)
Show SMILES COc1cc(ccc1-c1nc2c(C)nn(C3CCCCC3)c(=O)c2[nH]1)-c1n[nH]c(=O)o1
Show InChI InChI=1S/C21H22N6O4/c1-11-16-17(20(28)27(26-11)13-6-4-3-5-7-13)23-18(22-16)14-9-8-12(10-15(14)30-2)19-24-25-21(29)31-19/h8-10,13H,3-7H2,1-2H3,(H,22,23)(H,25,29)
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Glenmark Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibition of cloned human recombinant PDE7A assessed as [3H]cAMP hydrolysis by radiometric assay


Bioorg Med Chem Lett 22: 6286-91 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.077
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM50397065
PNG
(CHEMBL2171431)
Show SMILES COc1cc(ccc1-c1nc2c(C)nn(C3CCCCC3)c(=O)c2[nH]1)N1CCC(O)C1
Show InChI InChI=1S/C23H29N5O3/c1-14-20-21(23(30)28(26-14)15-6-4-3-5-7-15)25-22(24-20)18-9-8-16(12-19(18)31-2)27-11-10-17(29)13-27/h8-9,12,15,17,29H,3-7,10-11,13H2,1-2H3,(H,24,25)
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Glenmark Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibition of cloned human recombinant PDE7A assessed as [3H]cAMP hydrolysis by radiometric assay


Bioorg Med Chem Lett 22: 6286-91 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.077
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM50397069
PNG
(CHEMBL2171427)
Show SMILES COc1cc(ccc1-c1nc2c(C)nn(C3CCCCC3)c(=O)c2[nH]1)N1CC(N)C1
Show InChI InChI=1S/C22H28N6O2/c1-13-19-20(22(29)28(26-13)15-6-4-3-5-7-15)25-21(24-19)17-9-8-16(10-18(17)30-2)27-11-14(23)12-27/h8-10,14-15H,3-7,11-12,23H2,1-2H3,(H,24,25)
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Glenmark Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibition of cloned human recombinant PDE7A assessed as [3H]cAMP hydrolysis by radiometric assay


Bioorg Med Chem Lett 22: 6286-91 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.077
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM50397055
PNG
(CHEMBL2171442)
Show SMILES COc1cc(ccc1-c1nc2c(C)nn(C3CCCCCC3)c(=O)c2[nH]1)N1CCC(N)CC1
Show InChI InChI=1S/C25H34N6O2/c1-16-22-23(25(32)31(29-16)18-7-5-3-4-6-8-18)28-24(27-22)20-10-9-19(15-21(20)33-2)30-13-11-17(26)12-14-30/h9-10,15,17-18H,3-8,11-14,26H2,1-2H3,(H,27,28)
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Glenmark Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibition of cloned human recombinant PDE7A assessed as [3H]cAMP hydrolysis by radiometric assay


Bioorg Med Chem Lett 22: 6286-91 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.077
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM50397072
PNG
(CHEMBL2171426)
Show SMILES COc1cc(ccc1-c1nc2c(C)nn(C3CCCCC3)c(=O)c2[nH]1)N1CC[C@@H](N)C1 |r|
Show InChI InChI=1S/C23H30N6O2/c1-14-20-21(23(30)29(27-14)16-6-4-3-5-7-16)26-22(25-20)18-9-8-17(12-19(18)31-2)28-11-10-15(24)13-28/h8-9,12,15-16H,3-7,10-11,13,24H2,1-2H3,(H,25,26)/t15-/m1/s1
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n/an/a 77n/an/an/an/an/an/a



Glenmark Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibition of cloned human recombinant PDE7A assessed as [3H]cAMP hydrolysis by radiometric assay


Bioorg Med Chem Lett 22: 6286-91 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.077
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM50397071
PNG
(CHEMBL2171425)
Show SMILES COc1cc(ccc1-c1nc2c(C)nn(C3CCCCC3)c(=O)c2[nH]1)N1CC[C@H](N)C1 |r|
Show InChI InChI=1S/C23H30N6O2/c1-14-20-21(23(30)29(27-14)16-6-4-3-5-7-16)26-22(25-20)18-9-8-17(12-19(18)31-2)28-11-10-15(24)13-28/h8-9,12,15-16H,3-7,10-11,13,24H2,1-2H3,(H,25,26)/t15-/m0/s1
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n/an/a 80n/an/an/an/an/an/a



Glenmark Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibition of cloned human recombinant PDE7A assessed as [3H]cAMP hydrolysis by radiometric assay


Bioorg Med Chem Lett 22: 6286-91 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.077
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM50397064
PNG
(CHEMBL2171432)
Show SMILES COc1cc(ccc1-c1nc2c(C)nn(C3CCCCC3)c(=O)c2[nH]1)N1CCC(O)CC1
Show InChI InChI=1S/C24H31N5O3/c1-15-21-22(24(31)29(27-15)16-6-4-3-5-7-16)26-23(25-21)19-9-8-17(14-20(19)32-2)28-12-10-18(30)11-13-28/h8-9,14,16,18,30H,3-7,10-13H2,1-2H3,(H,25,26)
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n/an/a 81n/an/an/an/an/an/a



Glenmark Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibition of cloned human recombinant PDE7A assessed as [3H]cAMP hydrolysis by radiometric assay


Bioorg Med Chem Lett 22: 6286-91 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.077
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM50397058
PNG
(CHEMBL2171438)
Show SMILES COc1cc(C=CC(N)=O)ccc1-c1nc2c(C)nn(C3CCCCC3)c(=O)c2[nH]1 |w:5.4|
Show InChI InChI=1S/C22H25N5O3/c1-13-19-20(22(29)27(26-13)15-6-4-3-5-7-15)25-21(24-19)16-10-8-14(9-11-18(23)28)12-17(16)30-2/h8-12,15H,3-7H2,1-2H3,(H2,23,28)(H,24,25)
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n/an/a 89n/an/an/an/an/an/a



Glenmark Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibition of cloned human recombinant PDE7A assessed as [3H]cAMP hydrolysis by radiometric assay


Bioorg Med Chem Lett 22: 6286-91 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.077
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM50397057
PNG
(CHEMBL2171439)
Show SMILES COc1cc(CCC(N)=O)ccc1-c1nc2c(C)nn(C3CCCCC3)c(=O)c2[nH]1
Show InChI InChI=1S/C22H27N5O3/c1-13-19-20(22(29)27(26-13)15-6-4-3-5-7-15)25-21(24-19)16-10-8-14(9-11-18(23)28)12-17(16)30-2/h8,10,12,15H,3-7,9,11H2,1-2H3,(H2,23,28)(H,24,25)
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n/an/a 93n/an/an/an/an/an/a



Glenmark Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibition of cloned human recombinant PDE7A assessed as [3H]cAMP hydrolysis by radiometric assay


Bioorg Med Chem Lett 22: 6286-91 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.077
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM50397070
PNG
(CHEMBL2171424)
Show SMILES COc1cc(ccc1-c1nc2c(C)nn(C3CCCCC3)c(=O)c2[nH]1)N1CCNCC1
Show InChI InChI=1S/C23H30N6O2/c1-15-20-21(23(30)29(27-15)16-6-4-3-5-7-16)26-22(25-20)18-9-8-17(14-19(18)31-2)28-12-10-24-11-13-28/h8-9,14,16,24H,3-7,10-13H2,1-2H3,(H,25,26)
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n/an/a 104n/an/an/an/an/an/a



Glenmark Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibition of cloned human recombinant PDE7A assessed as [3H]cAMP hydrolysis by radiometric assay


Bioorg Med Chem Lett 22: 6286-91 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.077
More data for this
Ligand-Target Pair
Phosphodiesterase 4 and 5 (PDE4 and PDE5)


(Homo sapiens (Human))
BDBM50397052
PNG
(CHEMBL2171423)
Show SMILES COc1cc(ccc1-c1nc2c(C)nn(C3CCCCC3)c(=O)c2[nH]1)N1CCCNCC1
Show InChI InChI=1S/C24H32N6O2/c1-16-21-22(24(31)30(28-16)17-7-4-3-5-8-17)27-23(26-21)19-10-9-18(15-20(19)32-2)29-13-6-11-25-12-14-29/h9-10,15,17,25H,3-8,11-14H2,1-2H3,(H,26,27)
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n/an/a 2.90E+3n/an/an/an/an/an/a



Glenmark Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibition of cloned human recombinant PDE4D assessed as [3H]cAMP hydrolysis by radiometric assay


Bioorg Med Chem Lett 22: 6286-91 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.077
More data for this
Ligand-Target Pair
Phosphodiesterase 4 and 5 (PDE4 and PDE5)


(Homo sapiens (Human))
BDBM50397054
PNG
(CHEMBL2171421)
Show SMILES COc1cc(N)ccc1-c1nc2c(C)nn(C3CCCCC3)c(=O)c2[nH]1
Show InChI InChI=1S/C19H23N5O2/c1-11-16-17(19(25)24(23-11)13-6-4-3-5-7-13)22-18(21-16)14-9-8-12(20)10-15(14)26-2/h8-10,13H,3-7,20H2,1-2H3,(H,21,22)
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n/an/a 6.55E+3n/an/an/an/an/an/a



Glenmark Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibition of cloned human recombinant PDE4D assessed as [3H]cAMP hydrolysis by radiometric assay


Bioorg Med Chem Lett 22: 6286-91 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.077
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%