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PubMed code 23084901

Compile data set for download or QSAR
Found 30 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Peptidyl-glycine alpha-amidating monooxygenase


(Homo sapiens (Human))		BDBM50401749
PNG
(CHEMBL2207130)
Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCC(O)=O |r|
Show InChI InChI=1S/C52H73N11O15S2/c1-5-28(4)43-50(75)56-33(17-18-40(54)65)45(70)58-36(23-41(55)66)47(72)61-38(26-80-79-25-32(53)44(69)57-35(48(73)62-43)21-30-13-15-31(64)16-14-30)51(76)63-19-9-12-39(63)49(74)59-34(20-27(2)3)46(71)60-37(52(77)78-24-42(67)68)22-29-10-7-6-8-11-29/h6-8,10-11,13-16,27-28,32-39,43,64H,5,9,12,17-26,53H2,1-4H3,(H2,54,65)(H2,55,66)(H,56,75)(H,57,69)(H,58,70)(H,59,74)(H,60,71)(H,61,72)(H,62,73)(H,67,68)/t28-,32-,33-,34-,35-,36-,37-,38-,39-,43-/m0/s1
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n/an/a 2.00E+3n/an/an/an/an/an/a



Australian National University

Curated by ChEMBL


Assay Description
Competitive inhibition of PAM in human DMS53 cells using as(R)-Tyr-(S)-Val-Gly as substrate after 2 hrs by HPLC analysis

Bioorg Med Chem Lett 22: 7015-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.004
BindingDB Entry DOI: 10.7270/Q2VT1T73
More data for this
Ligand-Target Pair
Peptidyl-glycine alpha-amidating monooxygenase


(Homo sapiens (Human))		BDBM50401751
PNG
(CHEMBL2207128)
Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCC(O)=O |r|
Show InChI InChI=1S/C19H26N2O6/c1-12(2)9-15(20-13(3)22)18(25)21-16(19(26)27-11-17(23)24)10-14-7-5-4-6-8-14/h4-8,12,15-16H,9-11H2,1-3H3,(H,20,22)(H,21,25)(H,23,24)/t15-,16-/m0/s1
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n/an/a 3.00E+3n/an/an/an/an/an/a



Australian National University

Curated by ChEMBL


Assay Description
Competitive inhibition of PAM in human DMS53 cells using as(R)-Tyr-(S)-Val-Gly as substrate after 2 hrs by HPLC analysis

Bioorg Med Chem Lett 22: 7015-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.004
BindingDB Entry DOI: 10.7270/Q2VT1T73
More data for this
Ligand-Target Pair
Peptidyl-glycine alpha-amidating monooxygenase


(Homo sapiens (Human))		BDBM50401752
PNG
(CHEMBL2207127)
Show SMILES CC(=O)N[C@@H](Cc1ccccc1)C(=O)OCC(O)=O |r|
Show InChI InChI=1S/C13H15NO5/c1-9(15)14-11(13(18)19-8-12(16)17)7-10-5-3-2-4-6-10/h2-6,11H,7-8H2,1H3,(H,14,15)(H,16,17)/t11-/m0/s1
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n/an/a 5.00E+3n/an/an/an/an/an/a



Australian National University

Curated by ChEMBL


Assay Description
Competitive inhibition of PAM in human DMS53 cells using as(R)-Tyr-(S)-Val-Gly as substrate after 2 hrs by HPLC analysis

Bioorg Med Chem Lett 22: 7015-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.004
BindingDB Entry DOI: 10.7270/Q2VT1T73
More data for this
Ligand-Target Pair
Peptidyl-glycine alpha-amidating monooxygenase


(Homo sapiens (Human))		BDBM50401750
PNG
(CHEMBL2207129)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCC(O)=O |r|
Show InChI InChI=1S/C24H33N3O7/c1-15(2)12-18(25-23(32)20-10-7-11-27(20)16(3)28)22(31)26-19(24(33)34-14-21(29)30)13-17-8-5-4-6-9-17/h4-6,8-9,15,18-20H,7,10-14H2,1-3H3,(H,25,32)(H,26,31)(H,29,30)/t18-,19-,20-/m0/s1
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n/an/a 6.00E+3n/an/an/an/an/an/a



Australian National University

Curated by ChEMBL


Assay Description
Competitive inhibition of PAM in human DMS53 cells using as(R)-Tyr-(S)-Val-Gly as substrate after 2 hrs by HPLC analysis

Bioorg Med Chem Lett 22: 7015-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.004
BindingDB Entry DOI: 10.7270/Q2VT1T73
More data for this
Ligand-Target Pair
Peptidyl-glycine alpha-amidating monooxygenase


(Homo sapiens (Human))		BDBM50401751
PNG
(CHEMBL2207128)
Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCC(O)=O |r|
Show InChI InChI=1S/C19H26N2O6/c1-12(2)9-15(20-13(3)22)18(25)21-16(19(26)27-11-17(23)24)10-14-7-5-4-6-8-14/h4-8,12,15-16H,9-11H2,1-3H3,(H,20,22)(H,21,25)(H,23,24)/t15-,16-/m0/s1
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n/an/a 9.00E+3n/an/an/an/an/an/a



Australian National University

Curated by ChEMBL


Assay Description
Competitive inhibition of secreted PAM in human DMS53 cell culture medium using as(R)-Tyr-(S)-Val-Gly as substrate after 2 hrs by HPLC analysis

Bioorg Med Chem Lett 22: 7015-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.004
BindingDB Entry DOI: 10.7270/Q2VT1T73
More data for this
Ligand-Target Pair
Peptidyl-glycine alpha-amidating monooxygenase


(Homo sapiens (Human))		BDBM50401752
PNG
(CHEMBL2207127)
Show SMILES CC(=O)N[C@@H](Cc1ccccc1)C(=O)OCC(O)=O |r|
Show InChI InChI=1S/C13H15NO5/c1-9(15)14-11(13(18)19-8-12(16)17)7-10-5-3-2-4-6-10/h2-6,11H,7-8H2,1H3,(H,14,15)(H,16,17)/t11-/m0/s1
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n/an/a 1.10E+4n/an/an/an/an/an/a



Australian National University

Curated by ChEMBL


Assay Description
Competitive inhibition of secreted PAM in human DMS53 cell culture medium using as(R)-Tyr-(S)-Val-Gly as substrate after 2 hrs by HPLC analysis

Bioorg Med Chem Lett 22: 7015-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.004
BindingDB Entry DOI: 10.7270/Q2VT1T73
More data for this
Ligand-Target Pair
Peptidyl-glycine alpha-amidating monooxygenase


(Homo sapiens (Human))		BDBM50401756
PNG
(CHEMBL2207143)
Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)OCC(O)=O |r|
Show InChI InChI=1S/C45H67N11O15S2/c1-5-23(4)37-44(69)50-27(12-13-33(47)58)40(65)52-30(17-34(48)59)41(66)54-31(21-73-72-20-26(46)38(63)51-29(42(67)55-37)16-24-8-10-25(57)11-9-24)45(70)56-14-6-7-32(56)43(68)53-28(15-22(2)3)39(64)49-18-36(62)71-19-35(60)61/h8-11,22-23,26-32,37,57H,5-7,12-21,46H2,1-4H3,(H2,47,58)(H2,48,59)(H,49,64)(H,50,69)(H,51,63)(H,52,65)(H,53,68)(H,54,66)(H,55,67)(H,60,61)/t23-,26-,27-,28-,29-,30-,31-,32-,37-/m0/s1
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n/an/a 1.20E+4n/an/an/an/an/an/a



Australian National University

Curated by ChEMBL


Assay Description
Competitive inhibition of PAM in human DMS53 cells using as(R)-Tyr-(S)-Val-Gly as substrate after 2 hrs by HPLC analysis

Bioorg Med Chem Lett 22: 7015-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.004
BindingDB Entry DOI: 10.7270/Q2VT1T73
More data for this
Ligand-Target Pair
Peptidyl-glycine alpha-amidating monooxygenase


(Homo sapiens (Human))		BDBM50401749
PNG
(CHEMBL2207130)
Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCC(O)=O |r|
Show InChI InChI=1S/C52H73N11O15S2/c1-5-28(4)43-50(75)56-33(17-18-40(54)65)45(70)58-36(23-41(55)66)47(72)61-38(26-80-79-25-32(53)44(69)57-35(48(73)62-43)21-30-13-15-31(64)16-14-30)51(76)63-19-9-12-39(63)49(74)59-34(20-27(2)3)46(71)60-37(52(77)78-24-42(67)68)22-29-10-7-6-8-11-29/h6-8,10-11,13-16,27-28,32-39,43,64H,5,9,12,17-26,53H2,1-4H3,(H2,54,65)(H2,55,66)(H,56,75)(H,57,69)(H,58,70)(H,59,74)(H,60,71)(H,61,72)(H,62,73)(H,67,68)/t28-,32-,33-,34-,35-,36-,37-,38-,39-,43-/m0/s1
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n/an/a 2.30E+4n/an/an/an/an/an/a



Australian National University

Curated by ChEMBL


Assay Description
Competitive inhibition of secreted PAM in human DMS53 cell culture medium using as(R)-Tyr-(S)-Val-Gly as substrate after 2 hrs by HPLC analysis

Bioorg Med Chem Lett 22: 7015-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.004
BindingDB Entry DOI: 10.7270/Q2VT1T73
More data for this
Ligand-Target Pair
Peptidyl-glycine alpha-amidating monooxygenase


(Homo sapiens (Human))		BDBM50401750
PNG
(CHEMBL2207129)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCC(O)=O |r|
Show InChI InChI=1S/C24H33N3O7/c1-15(2)12-18(25-23(32)20-10-7-11-27(20)16(3)28)22(31)26-19(24(33)34-14-21(29)30)13-17-8-5-4-6-9-17/h4-6,8-9,15,18-20H,7,10-14H2,1-3H3,(H,25,32)(H,26,31)(H,29,30)/t18-,19-,20-/m0/s1
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n/an/a 3.80E+4n/an/an/an/an/an/a



Australian National University

Curated by ChEMBL


Assay Description
Competitive inhibition of secreted PAM in human DMS53 cell culture medium using as(R)-Tyr-(S)-Val-Gly as substrate after 2 hrs by HPLC analysis

Bioorg Med Chem Lett 22: 7015-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.004
BindingDB Entry DOI: 10.7270/Q2VT1T73
More data for this
Ligand-Target Pair
Peptidyl-glycine alpha-amidating monooxygenase


(Homo sapiens (Human))		BDBM50401756
PNG
(CHEMBL2207143)
Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)OCC(O)=O |r|
Show InChI InChI=1S/C45H67N11O15S2/c1-5-23(4)37-44(69)50-27(12-13-33(47)58)40(65)52-30(17-34(48)59)41(66)54-31(21-73-72-20-26(46)38(63)51-29(42(67)55-37)16-24-8-10-25(57)11-9-24)45(70)56-14-6-7-32(56)43(68)53-28(15-22(2)3)39(64)49-18-36(62)71-19-35(60)61/h8-11,22-23,26-32,37,57H,5-7,12-21,46H2,1-4H3,(H2,47,58)(H2,48,59)(H,49,64)(H,50,69)(H,51,63)(H,52,65)(H,53,68)(H,54,66)(H,55,67)(H,60,61)/t23-,26-,27-,28-,29-,30-,31-,32-,37-/m0/s1
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n/an/a 7.10E+4n/an/an/an/an/an/a



Australian National University

Curated by ChEMBL


Assay Description
Competitive inhibition of secreted PAM in human DMS53 cell culture medium using as(R)-Tyr-(S)-Val-Gly as substrate after 2 hrs by HPLC analysis

Bioorg Med Chem Lett 22: 7015-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.004
BindingDB Entry DOI: 10.7270/Q2VT1T73
More data for this
Ligand-Target Pair
Peptidyl-glycine alpha-amidating monooxygenase


(Homo sapiens (Human))		BDBM50401757
PNG
(CHEMBL2207142)
Show SMILES CC(C)C[C@H](OC(=O)[C@@H]1CCCN1C(C)=O)C(=O)NCC(=O)OCC(O)=O |r|
Show InChI InChI=1S/C17H26N2O8/c1-10(2)7-13(16(24)18-8-15(23)26-9-14(21)22)27-17(25)12-5-4-6-19(12)11(3)20/h10,12-13H,4-9H2,1-3H3,(H,18,24)(H,21,22)/t12-,13-/m0/s1
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n/an/a 7.60E+4n/an/an/an/an/an/a



Australian National University

Curated by ChEMBL


Assay Description
Competitive inhibition of PAM in human DMS53 cells using as(R)-Tyr-(S)-Val-Gly as substrate after 2 hrs by HPLC analysis

Bioorg Med Chem Lett 22: 7015-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.004
BindingDB Entry DOI: 10.7270/Q2VT1T73
More data for this
Ligand-Target Pair
Peptidyl-glycine alpha-amidating monooxygenase


(Homo sapiens (Human))		BDBM50401758
PNG
(CHEMBL2207141)
Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)NCC(=O)OCC(O)=O |r|
Show InChI InChI=1S/C12H20N2O6/c1-7(2)4-9(14-8(3)15)12(19)13-5-11(18)20-6-10(16)17/h7,9H,4-6H2,1-3H3,(H,13,19)(H,14,15)(H,16,17)/t9-/m0/s1
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n/an/a 1.20E+5n/an/an/an/an/an/a



Australian National University

Curated by ChEMBL


Assay Description
Competitive inhibition of PAM in human DMS53 cells using as(R)-Tyr-(S)-Val-Gly as substrate after 2 hrs by HPLC analysis

Bioorg Med Chem Lett 22: 7015-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.004
BindingDB Entry DOI: 10.7270/Q2VT1T73
More data for this
Ligand-Target Pair
Peptidyl-glycine alpha-amidating monooxygenase


(Homo sapiens (Human))		BDBM50401746
PNG
(CHEMBL2207133)
Show SMILES C[C@H](NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCC(O)=O |r|
Show InChI InChI=1S/C16H21N3O6/c1-10(18-13(20)8-17)15(23)19-12(16(24)25-9-14(21)22)7-11-5-3-2-4-6-11/h2-6,10,12H,7-9,17H2,1H3,(H,18,20)(H,19,23)(H,21,22)/t10-,12-/m0/s1
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n/an/a 1.60E+5n/an/an/an/an/an/a



Australian National University

Curated by ChEMBL


Assay Description
Competitive inhibition of secreted PAM in human DMS53 cell culture medium using as(R)-Tyr-(S)-Val-Gly as substrate after 2 hrs by HPLC analysis

Bioorg Med Chem Lett 22: 7015-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.004
BindingDB Entry DOI: 10.7270/Q2VT1T73
More data for this
Ligand-Target Pair
Peptidyl-glycine alpha-amidating monooxygenase


(Homo sapiens (Human))		BDBM50401757
PNG
(CHEMBL2207142)
Show SMILES CC(C)C[C@H](OC(=O)[C@@H]1CCCN1C(C)=O)C(=O)NCC(=O)OCC(O)=O |r|
Show InChI InChI=1S/C17H26N2O8/c1-10(2)7-13(16(24)18-8-15(23)26-9-14(21)22)27-17(25)12-5-4-6-19(12)11(3)20/h10,12-13H,4-9H2,1-3H3,(H,18,24)(H,21,22)/t12-,13-/m0/s1
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n/an/a 1.80E+5n/an/an/an/an/an/a



Australian National University

Curated by ChEMBL


Assay Description
Competitive inhibition of secreted PAM in human DMS53 cell culture medium using as(R)-Tyr-(S)-Val-Gly as substrate after 2 hrs by HPLC analysis

Bioorg Med Chem Lett 22: 7015-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.004
BindingDB Entry DOI: 10.7270/Q2VT1T73
More data for this
Ligand-Target Pair
Peptidyl-glycine alpha-amidating monooxygenase


(Homo sapiens (Human))		BDBM50401758
PNG
(CHEMBL2207141)
Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)NCC(=O)OCC(O)=O |r|
Show InChI InChI=1S/C12H20N2O6/c1-7(2)4-9(14-8(3)15)12(19)13-5-11(18)20-6-10(16)17/h7,9H,4-6H2,1-3H3,(H,13,19)(H,14,15)(H,16,17)/t9-/m0/s1
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n/an/a 2.00E+5n/an/an/an/an/an/a



Australian National University

Curated by ChEMBL


Assay Description
Competitive inhibition of secreted PAM in human DMS53 cell culture medium using as(R)-Tyr-(S)-Val-Gly as substrate after 2 hrs by HPLC analysis

Bioorg Med Chem Lett 22: 7015-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.004
BindingDB Entry DOI: 10.7270/Q2VT1T73
More data for this
Ligand-Target Pair
Peptidyl-glycine alpha-amidating monooxygenase


(Homo sapiens (Human))		BDBM50401759
PNG
(CHEMBL2207140)
Show SMILES CC(=O)NCC(=O)OCC(O)=O
Show InChI InChI=1S/C6H9NO5/c1-4(8)7-2-6(11)12-3-5(9)10/h2-3H2,1H3,(H,7,8)(H,9,10)
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n/an/a 2.10E+5n/an/an/an/an/an/a



Australian National University

Curated by ChEMBL


Assay Description
Competitive inhibition of PAM in human DMS53 cells using as(R)-Tyr-(S)-Val-Gly as substrate after 2 hrs by HPLC analysis

Bioorg Med Chem Lett 22: 7015-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.004
BindingDB Entry DOI: 10.7270/Q2VT1T73
More data for this
Ligand-Target Pair
Peptidyl-glycine alpha-amidating monooxygenase


(Homo sapiens (Human))		BDBM50401754
PNG
(CHEMBL2207145)
Show SMILES C[C@H](N)C(=O)N1CCC[C@H]1C(=O)OCC(O)=O |r|
Show InChI InChI=1S/C10H16N2O5/c1-6(11)9(15)12-4-2-3-7(12)10(16)17-5-8(13)14/h6-7H,2-5,11H2,1H3,(H,13,14)/t6-,7-/m0/s1
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n/an/a 2.90E+5n/an/an/an/an/an/a



Australian National University

Curated by ChEMBL


Assay Description
Competitive inhibition of secreted PAM in human DMS53 cell culture medium using as(R)-Tyr-(S)-Val-Gly as substrate after 2 hrs by HPLC analysis

Bioorg Med Chem Lett 22: 7015-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.004
BindingDB Entry DOI: 10.7270/Q2VT1T73
More data for this
Ligand-Target Pair
Peptidyl-glycine alpha-amidating monooxygenase


(Homo sapiens (Human))		BDBM50401747
PNG
(CHEMBL2207132)
Show SMILES C[C@H](N)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCC(O)=O |r|
Show InChI InChI=1S/C14H18N2O5/c1-9(15)13(19)16-11(14(20)21-8-12(17)18)7-10-5-3-2-4-6-10/h2-6,9,11H,7-8,15H2,1H3,(H,16,19)(H,17,18)/t9-,11-/m0/s1
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n/an/a 3.50E+5n/an/an/an/an/an/a



Australian National University

Curated by ChEMBL


Assay Description
Competitive inhibition of PAM in human DMS53 cells using as(R)-Tyr-(S)-Val-Gly as substrate after 2 hrs by HPLC analysis

Bioorg Med Chem Lett 22: 7015-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.004
BindingDB Entry DOI: 10.7270/Q2VT1T73
More data for this
Ligand-Target Pair
Peptidyl-glycine alpha-amidating monooxygenase


(Homo sapiens (Human))		BDBM50401754
PNG
(CHEMBL2207145)
Show SMILES C[C@H](N)C(=O)N1CCC[C@H]1C(=O)OCC(O)=O |r|
Show InChI InChI=1S/C10H16N2O5/c1-6(11)9(15)12-4-2-3-7(12)10(16)17-5-8(13)14/h6-7H,2-5,11H2,1H3,(H,13,14)/t6-,7-/m0/s1
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n/an/a 3.70E+5n/an/an/an/an/an/a



Australian National University

Curated by ChEMBL


Assay Description
Competitive inhibition of PAM in human DMS53 cells using as(R)-Tyr-(S)-Val-Gly as substrate after 2 hrs by HPLC analysis

Bioorg Med Chem Lett 22: 7015-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.004
BindingDB Entry DOI: 10.7270/Q2VT1T73
More data for this
Ligand-Target Pair
Peptidyl-glycine alpha-amidating monooxygenase


(Homo sapiens (Human))		BDBM50401747
PNG
(CHEMBL2207132)
Show SMILES C[C@H](N)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCC(O)=O |r|
Show InChI InChI=1S/C14H18N2O5/c1-9(15)13(19)16-11(14(20)21-8-12(17)18)7-10-5-3-2-4-6-10/h2-6,9,11H,7-8,15H2,1H3,(H,16,19)(H,17,18)/t9-,11-/m0/s1
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n/an/a 3.70E+5n/an/an/an/an/an/a



Australian National University

Curated by ChEMBL


Assay Description
Competitive inhibition of secreted PAM in human DMS53 cell culture medium using as(R)-Tyr-(S)-Val-Gly as substrate after 2 hrs by HPLC analysis

Bioorg Med Chem Lett 22: 7015-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.004
BindingDB Entry DOI: 10.7270/Q2VT1T73
More data for this
Ligand-Target Pair
Peptidyl-glycine alpha-amidating monooxygenase


(Homo sapiens (Human))		BDBM50401755
PNG
(CHEMBL2207144)
Show SMILES OC(=O)COC(=O)[C@@H]1CCCN1 |r|
Show InChI InChI=1S/C7H11NO4/c9-6(10)4-12-7(11)5-2-1-3-8-5/h5,8H,1-4H2,(H,9,10)/t5-/m0/s1
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n/an/a 5.00E+5n/an/an/an/an/an/a



Australian National University

Curated by ChEMBL


Assay Description
Competitive inhibition of secreted PAM in human DMS53 cell culture medium using as(R)-Tyr-(S)-Val-Gly as substrate after 2 hrs by HPLC analysis

Bioorg Med Chem Lett 22: 7015-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.004
BindingDB Entry DOI: 10.7270/Q2VT1T73
More data for this
Ligand-Target Pair
Peptidyl-glycine alpha-amidating monooxygenase


(Homo sapiens (Human))		BDBM50401746
PNG
(CHEMBL2207133)
Show SMILES C[C@H](NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCC(O)=O |r|
Show InChI InChI=1S/C16H21N3O6/c1-10(18-13(20)8-17)15(23)19-12(16(24)25-9-14(21)22)7-11-5-3-2-4-6-11/h2-6,10,12H,7-9,17H2,1H3,(H,18,20)(H,19,23)(H,21,22)/t10-,12-/m0/s1
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n/an/a 5.60E+5n/an/an/an/an/an/a



Australian National University

Curated by ChEMBL


Assay Description
Competitive inhibition of PAM in human DMS53 cells using as(R)-Tyr-(S)-Val-Gly as substrate after 2 hrs by HPLC analysis

Bioorg Med Chem Lett 22: 7015-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.004
BindingDB Entry DOI: 10.7270/Q2VT1T73
More data for this
Ligand-Target Pair
Peptidyl-glycine alpha-amidating monooxygenase


(Homo sapiens (Human))		BDBM50401755
PNG
(CHEMBL2207144)
Show SMILES OC(=O)COC(=O)[C@@H]1CCCN1 |r|
Show InChI InChI=1S/C7H11NO4/c9-6(10)4-12-7(11)5-2-1-3-8-5/h5,8H,1-4H2,(H,9,10)/t5-/m0/s1
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n/an/a 6.00E+5n/an/an/an/an/an/a



Australian National University

Curated by ChEMBL


Assay Description
Competitive inhibition of PAM in human DMS53 cells using as(R)-Tyr-(S)-Val-Gly as substrate after 2 hrs by HPLC analysis

Bioorg Med Chem Lett 22: 7015-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.004
BindingDB Entry DOI: 10.7270/Q2VT1T73
More data for this
Ligand-Target Pair
Peptidyl-glycine alpha-amidating monooxygenase


(Homo sapiens (Human))		BDBM50401753
PNG
(CHEMBL2207146)
Show SMILES C[C@H](NC(=O)CN)C(=O)N1CCC[C@H]1C(=O)OCC(O)=O |r|
Show InChI InChI=1S/C12H19N3O6/c1-7(14-9(16)5-13)11(19)15-4-2-3-8(15)12(20)21-6-10(17)18/h7-8H,2-6,13H2,1H3,(H,14,16)(H,17,18)/t7-,8-/m0/s1
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n/an/a 9.80E+5n/an/an/an/an/an/a



Australian National University

Curated by ChEMBL


Assay Description
Competitive inhibition of PAM in human DMS53 cells using as(R)-Tyr-(S)-Val-Gly as substrate after 2 hrs by HPLC analysis

Bioorg Med Chem Lett 22: 7015-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.004
BindingDB Entry DOI: 10.7270/Q2VT1T73
More data for this
Ligand-Target Pair
Peptidyl-glycine alpha-amidating monooxygenase


(Homo sapiens (Human))		BDBM82195
PNG
(Substrate analogue, 13)
Show SMILES CC(=O)OCC(O)=O
Show InChI InChI=1S/C4H6O4/c1-3(5)8-2-4(6)7/h2H2,1H3,(H,6,7)
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n/an/a 1.10E+6n/an/an/an/an/an/a



Australian National University

Curated by ChEMBL


Assay Description
Competitive inhibition of secreted PAM in human DMS53 cell culture medium using as(R)-Tyr-(S)-Val-Gly as substrate after 2 hrs by HPLC analysis

Bioorg Med Chem Lett 22: 7015-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.004
BindingDB Entry DOI: 10.7270/Q2VT1T73
More data for this
Ligand-Target Pair
Peptidyl-glycine alpha-amidating monooxygenase


(Homo sapiens (Human))		BDBM50401748
PNG
(CHEMBL2207131)
Show SMILES N[C@@H](Cc1ccccc1)C(=O)OCC(O)=O |r|
Show InChI InChI=1S/C11H13NO4/c12-9(11(15)16-7-10(13)14)6-8-4-2-1-3-5-8/h1-5,9H,6-7,12H2,(H,13,14)/t9-/m0/s1
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n/an/a 1.10E+6n/an/an/an/an/an/a



Australian National University

Curated by ChEMBL


Assay Description
Competitive inhibition of PAM in human DMS53 cells using as(R)-Tyr-(S)-Val-Gly as substrate after 2 hrs by HPLC analysis

Bioorg Med Chem Lett 22: 7015-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.004
BindingDB Entry DOI: 10.7270/Q2VT1T73
More data for this
Ligand-Target Pair
Peptidyl-glycine alpha-amidating monooxygenase


(Homo sapiens (Human))		BDBM50401753
PNG
(CHEMBL2207146)
Show SMILES C[C@H](NC(=O)CN)C(=O)N1CCC[C@H]1C(=O)OCC(O)=O |r|
Show InChI InChI=1S/C12H19N3O6/c1-7(14-9(16)5-13)11(19)15-4-2-3-8(15)12(20)21-6-10(17)18/h7-8H,2-6,13H2,1H3,(H,14,16)(H,17,18)/t7-,8-/m0/s1
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n/an/a 1.10E+6n/an/an/an/an/an/a



Australian National University

Curated by ChEMBL


Assay Description
Competitive inhibition of secreted PAM in human DMS53 cell culture medium using as(R)-Tyr-(S)-Val-Gly as substrate after 2 hrs by HPLC analysis

Bioorg Med Chem Lett 22: 7015-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.004
BindingDB Entry DOI: 10.7270/Q2VT1T73
More data for this
Ligand-Target Pair
Peptidyl-glycine alpha-amidating monooxygenase


(Homo sapiens (Human))		BDBM82195
PNG
(Substrate analogue, 13)
Show SMILES CC(=O)OCC(O)=O
Show InChI InChI=1S/C4H6O4/c1-3(5)8-2-4(6)7/h2H2,1H3,(H,6,7)
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n/an/a 1.10E+6n/an/an/an/an/an/a



Australian National University

Curated by ChEMBL


Assay Description
Competitive inhibition of PAM in human DMS53 cells using as(R)-Tyr-(S)-Val-Gly as substrate after 2 hrs by HPLC analysis

Bioorg Med Chem Lett 22: 7015-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.004
BindingDB Entry DOI: 10.7270/Q2VT1T73
More data for this
Ligand-Target Pair
Peptidyl-glycine alpha-amidating monooxygenase


(Homo sapiens (Human))		BDBM50401748
PNG
(CHEMBL2207131)
Show SMILES N[C@@H](Cc1ccccc1)C(=O)OCC(O)=O |r|
Show InChI InChI=1S/C11H13NO4/c12-9(11(15)16-7-10(13)14)6-8-4-2-1-3-5-8/h1-5,9H,6-7,12H2,(H,13,14)/t9-/m0/s1
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n/an/a 1.60E+6n/an/an/an/an/an/a



Australian National University

Curated by ChEMBL


Assay Description
Competitive inhibition of secreted PAM in human DMS53 cell culture medium using as(R)-Tyr-(S)-Val-Gly as substrate after 2 hrs by HPLC analysis

Bioorg Med Chem Lett 22: 7015-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.004
BindingDB Entry DOI: 10.7270/Q2VT1T73
More data for this
Ligand-Target Pair
Peptidyl-glycine alpha-amidating monooxygenase


(Homo sapiens (Human))		BDBM50401759
PNG
(CHEMBL2207140)
Show SMILES CC(=O)NCC(=O)OCC(O)=O
Show InChI InChI=1S/C6H9NO5/c1-4(8)7-2-6(11)12-3-5(9)10/h2-3H2,1H3,(H,7,8)(H,9,10)
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n/an/a 1.80E+6n/an/an/an/an/an/a



Australian National University

Curated by ChEMBL


Assay Description
Competitive inhibition of secreted PAM in human DMS53 cell culture medium using as(R)-Tyr-(S)-Val-Gly as substrate after 2 hrs by HPLC analysis

Bioorg Med Chem Lett 22: 7015-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.004
BindingDB Entry DOI: 10.7270/Q2VT1T73
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%