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PubMed code 23099096

Compile data set for download or QSAR
Found 88 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50401954
PNG
(CHEMBL2207636)
Show SMILES COc1ccccc1N1CCN(Cc2cc(C#N)c3cccccc23)CC1
Show InChI InChI=1S/C23H23N3O/c1-27-23-10-6-5-9-22(23)26-13-11-25(12-14-26)17-19-15-18(16-24)20-7-3-2-4-8-21(19)20/h2-10,15H,11-14,17H2,1H3
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8.30n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2long receptor expressed in CHO cells after 60 mins by scintillation counting analysis


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50401944
PNG
(CHEMBL2207641)
Show SMILES COc1ccccc1N1CCN(Cc2cc(CN3CCN(CC3)c3ccccc3OC)c3cccccc23)CC1
Show InChI InChI=1S/C34H40N4O2/c1-39-33-14-8-6-12-31(33)37-20-16-35(17-21-37)25-27-24-28(30-11-5-3-4-10-29(27)30)26-36-18-22-38(23-19-36)32-13-7-9-15-34(32)40-2/h3-15,24H,16-23,25-26H2,1-2H3
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17n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2long receptor expressed in CHO cells after 60 mins by scintillation counting analysis


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50401953
PNG
(CHEMBL2207643)
Show SMILES COc1ccccc1N1CCN(Cc2ccc3cccccc23)CC1
Show InChI InChI=1S/C22H24N2O/c1-25-22-10-6-5-9-21(22)24-15-13-23(14-16-24)17-19-12-11-18-7-3-2-4-8-20(18)19/h2-12H,13-17H2,1H3
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24n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2short receptor expressed in CHO cells after 60 mins by scintillation counting analysis


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50401953
PNG
(CHEMBL2207643)
Show SMILES COc1ccccc1N1CCN(Cc2ccc3cccccc23)CC1
Show InChI InChI=1S/C22H24N2O/c1-25-22-10-6-5-9-21(22)24-15-13-23(14-16-24)17-19-12-11-18-7-3-2-4-8-20(18)19/h2-12H,13-17H2,1H3
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33n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2long receptor expressed in CHO cells after 60 mins by scintillation counting analysis


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50401944
PNG
(CHEMBL2207641)
Show SMILES COc1ccccc1N1CCN(Cc2cc(CN3CCN(CC3)c3ccccc3OC)c3cccccc23)CC1
Show InChI InChI=1S/C34H40N4O2/c1-39-33-14-8-6-12-31(33)37-20-16-35(17-21-37)25-27-24-28(30-11-5-3-4-10-29(27)30)26-36-18-22-38(23-19-36)32-13-7-9-15-34(32)40-2/h3-15,24H,16-23,25-26H2,1-2H3
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33n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cells after 60 mins by scintillation counting analysis


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50401944
PNG
(CHEMBL2207641)
Show SMILES COc1ccccc1N1CCN(Cc2cc(CN3CCN(CC3)c3ccccc3OC)c3cccccc23)CC1
Show InChI InChI=1S/C34H40N4O2/c1-39-33-14-8-6-12-31(33)37-20-16-35(17-21-37)25-27-24-28(30-11-5-3-4-10-29(27)30)26-36-18-22-38(23-19-36)32-13-7-9-15-34(32)40-2/h3-15,24H,16-23,25-26H2,1-2H3
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34n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2short receptor expressed in CHO cells after 60 mins by scintillation counting analysis


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50401947
PNG
(CHEMBL2207638)
Show SMILES COc1ccccc1N1CCN(Cc2cc(CN3CCCCC3)c3cccccc23)CC1
Show InChI InChI=1S/C28H35N3O/c1-32-28-13-7-6-12-27(28)31-18-16-30(17-19-31)22-24-20-23(21-29-14-8-3-9-15-29)25-10-4-2-5-11-26(24)25/h2,4-7,10-13,20H,3,8-9,14-19,21-22H2,1H3
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37n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2short receptor expressed in CHO cells after 60 mins by scintillation counting analysis


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50401954
PNG
(CHEMBL2207636)
Show SMILES COc1ccccc1N1CCN(Cc2cc(C#N)c3cccccc23)CC1
Show InChI InChI=1S/C23H23N3O/c1-27-23-10-6-5-9-22(23)26-13-11-25(12-14-26)17-19-15-18(16-24)20-7-3-2-4-8-21(19)20/h2-10,15H,11-14,17H2,1H3
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39n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2short receptor expressed in CHO cells after 60 mins by scintillation counting analysis


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50401947
PNG
(CHEMBL2207638)
Show SMILES COc1ccccc1N1CCN(Cc2cc(CN3CCCCC3)c3cccccc23)CC1
Show InChI InChI=1S/C28H35N3O/c1-32-28-13-7-6-12-27(28)31-18-16-30(17-19-31)22-24-20-23(21-29-14-8-3-9-15-29)25-10-4-2-5-11-26(24)25/h2,4-7,10-13,20H,3,8-9,14-19,21-22H2,1H3
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51n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2long receptor expressed in CHO cells after 60 mins by scintillation counting analysis


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50401945
PNG
(CHEMBL2207640)
Show SMILES COc1ccccc1N1CCN(Cc2cc(CN3CCN(C)CC3)c3cccccc23)CC1
Show InChI InChI=1S/C28H36N4O/c1-29-12-14-30(15-13-29)21-23-20-24(26-9-5-3-4-8-25(23)26)22-31-16-18-32(19-17-31)27-10-6-7-11-28(27)33-2/h3-11,20H,12-19,21-22H2,1-2H3
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57n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2short receptor expressed in CHO cells after 60 mins by scintillation counting analysis


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50401945
PNG
(CHEMBL2207640)
Show SMILES COc1ccccc1N1CCN(Cc2cc(CN3CCN(C)CC3)c3cccccc23)CC1
Show InChI InChI=1S/C28H36N4O/c1-29-12-14-30(15-13-29)21-23-20-24(26-9-5-3-4-8-25(23)26)22-31-16-18-32(19-17-31)27-10-6-7-11-28(27)33-2/h3-11,20H,12-19,21-22H2,1-2H3
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60n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2long receptor expressed in CHO cells after 60 mins by scintillation counting analysis


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50401950
PNG
(CHEMBL2207634)
Show SMILES CCCC#Cc1cc(CN2CCN(CC2)c2ccccc2OC)c2cccccc12
Show InChI InChI=1S/C27H30N2O/c1-3-4-6-11-22-20-23(25-13-8-5-7-12-24(22)25)21-28-16-18-29(19-17-28)26-14-9-10-15-27(26)30-2/h5,7-10,12-15,20H,3-4,16-19,21H2,1-2H3
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60n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2short receptor expressed in CHO cells after 60 mins by scintillation counting analysis


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50401951
PNG
(CHEMBL2207633)
Show SMILES COc1ccccc1N1CCN(Cc2cc(C#Cc3ccccc3)c3cccccc23)CC1
Show InChI InChI=1S/C30H28N2O/c1-33-30-15-9-8-14-29(30)32-20-18-31(19-21-32)23-26-22-25(17-16-24-10-4-2-5-11-24)27-12-6-3-7-13-28(26)27/h2-15,22H,18-21,23H2,1H3
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65n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2long receptor expressed in CHO cells after 60 mins by scintillation counting analysis


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50401951
PNG
(CHEMBL2207633)
Show SMILES COc1ccccc1N1CCN(Cc2cc(C#Cc3ccccc3)c3cccccc23)CC1
Show InChI InChI=1S/C30H28N2O/c1-33-30-15-9-8-14-29(30)32-20-18-31(19-21-32)23-26-22-25(17-16-24-10-4-2-5-11-24)27-12-6-3-7-13-28(26)27/h2-15,22H,18-21,23H2,1H3
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67n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2short receptor expressed in CHO cells after 60 mins by scintillation counting analysis


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50401949
PNG
(CHEMBL2207635)
Show SMILES COc1ccccc1N1CCN(Cc2cc(CO)c3cccccc23)CC1
Show InChI InChI=1S/C23H26N2O2/c1-27-23-10-6-5-9-22(23)25-13-11-24(12-14-25)16-18-15-19(17-26)21-8-4-2-3-7-20(18)21/h2-10,15,26H,11-14,16-17H2,1H3
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68n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2short receptor expressed in CHO cells after 60 mins by scintillation counting analysis


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50401952
PNG
(CHEMBL2207632)
Show SMILES COc1ccccc1N1CCN(Cc2cc(C#C)c3cccccc23)CC1
Show InChI InChI=1S/C24H24N2O/c1-3-19-17-20(22-10-6-4-5-9-21(19)22)18-25-13-15-26(16-14-25)23-11-7-8-12-24(23)27-2/h1,4-12,17H,13-16,18H2,2H3
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76n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2short receptor expressed in CHO cells after 60 mins by scintillation counting analysis


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50401950
PNG
(CHEMBL2207634)
Show SMILES CCCC#Cc1cc(CN2CCN(CC2)c2ccccc2OC)c2cccccc12
Show InChI InChI=1S/C27H30N2O/c1-3-4-6-11-22-20-23(25-13-8-5-7-12-24(22)25)21-28-16-18-29(19-17-28)26-14-9-10-15-27(26)30-2/h5,7-10,12-15,20H,3-4,16-19,21H2,1-2H3
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76n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2long receptor expressed in CHO cells after 60 mins by scintillation counting analysis


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50401953
PNG
(CHEMBL2207643)
Show SMILES COc1ccccc1N1CCN(Cc2ccc3cccccc23)CC1
Show InChI InChI=1S/C22H24N2O/c1-25-22-10-6-5-9-21(22)24-15-13-23(14-16-24)17-19-12-11-18-7-3-2-4-8-20(18)19/h2-12H,13-17H2,1H3
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83n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cells after 60 mins by scintillation counting analysis


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50401943
PNG
(CHEMBL2207642)
Show SMILES COc1ccccc1N1CCN(Cc2cc(CN3CCN(CC3)c3ccc(Cl)cc3)c3cccccc23)CC1
Show InChI InChI=1S/C33H37ClN4O/c1-39-33-10-6-5-9-32(33)38-21-17-36(18-22-38)25-27-23-26(30-7-3-2-4-8-31(27)30)24-35-15-19-37(20-16-35)29-13-11-28(34)12-14-29/h2-14,23H,15-22,24-25H2,1H3
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85n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cells after 60 mins by scintillation counting analysis


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50401946
PNG
(CHEMBL2207639)
Show SMILES COc1ccccc1N1CCN(Cc2cc(CN3CCOCC3)c3cccccc23)CC1
Show InChI InChI=1S/C27H33N3O2/c1-31-27-10-6-5-9-26(27)30-13-11-28(12-14-30)20-22-19-23(21-29-15-17-32-18-16-29)25-8-4-2-3-7-24(22)25/h2-10,19H,11-18,20-21H2,1H3
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92n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2short receptor expressed in CHO cells after 60 mins by scintillation counting analysis


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
5-HT2


(PIG)
BDBM50401953
PNG
(CHEMBL2207643)
Show SMILES COc1ccccc1N1CCN(Cc2ccc3cccccc23)CC1
Show InChI InChI=1S/C22H24N2O/c1-25-22-10-6-5-9-21(22)24-15-13-23(14-16-24)17-19-12-11-18-7-3-2-4-8-20(18)19/h2-12H,13-17H2,1H3
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92n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5-HT2 receptor in porcine cerebral cortex homogenate after 60 mins by scintillation counting analysis


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50401943
PNG
(CHEMBL2207642)
Show SMILES COc1ccccc1N1CCN(Cc2cc(CN3CCN(CC3)c3ccc(Cl)cc3)c3cccccc23)CC1
Show InChI InChI=1S/C33H37ClN4O/c1-39-33-10-6-5-9-32(33)38-21-17-36(18-22-38)25-27-23-26(30-7-3-2-4-8-31(27)30)24-35-15-19-37(20-16-35)29-13-11-28(34)12-14-29/h2-14,23H,15-22,24-25H2,1H3
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95n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2long receptor expressed in CHO cells after 60 mins by scintillation counting analysis


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50401952
PNG
(CHEMBL2207632)
Show SMILES COc1ccccc1N1CCN(Cc2cc(C#C)c3cccccc23)CC1
Show InChI InChI=1S/C24H24N2O/c1-3-19-17-20(22-10-6-4-5-9-21(19)22)18-25-13-15-26(16-14-25)23-11-7-8-12-24(23)27-2/h1,4-12,17H,13-16,18H2,2H3
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95n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2long receptor expressed in CHO cells after 60 mins by scintillation counting analysis


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50401946
PNG
(CHEMBL2207639)
Show SMILES COc1ccccc1N1CCN(Cc2cc(CN3CCOCC3)c3cccccc23)CC1
Show InChI InChI=1S/C27H33N3O2/c1-31-27-10-6-5-9-26(27)30-13-11-28(12-14-30)20-22-19-23(21-29-15-17-32-18-16-29)25-8-4-2-3-7-24(22)25/h2-10,19H,11-18,20-21H2,1H3
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130n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2long receptor expressed in CHO cells after 60 mins by scintillation counting analysis


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50401948
PNG
(CHEMBL2207637)
Show SMILES COc1ccccc1N1CCN(Cc2cc(CN(C)C)c3cccccc23)CC1
Show InChI InChI=1S/C25H31N3O/c1-26(2)18-20-17-21(23-10-6-4-5-9-22(20)23)19-27-13-15-28(16-14-27)24-11-7-8-12-25(24)29-3/h4-12,17H,13-16,18-19H2,1-3H3
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140n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2short receptor expressed in CHO cells after 60 mins by scintillation counting analysis


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50401949
PNG
(CHEMBL2207635)
Show SMILES COc1ccccc1N1CCN(Cc2cc(CO)c3cccccc23)CC1
Show InChI InChI=1S/C23H26N2O2/c1-27-23-10-6-5-9-22(23)25-13-11-24(12-14-25)16-18-15-19(17-26)21-8-4-2-3-7-20(18)21/h2-10,15,26H,11-14,16-17H2,1H3
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150n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2long receptor expressed in CHO cells after 60 mins by scintillation counting analysis


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50401947
PNG
(CHEMBL2207638)
Show SMILES COc1ccccc1N1CCN(Cc2cc(CN3CCCCC3)c3cccccc23)CC1
Show InChI InChI=1S/C28H35N3O/c1-32-28-13-7-6-12-27(28)31-18-16-30(17-19-31)22-24-20-23(21-29-14-8-3-9-15-29)25-10-4-2-5-11-26(24)25/h2,4-7,10-13,20H,3,8-9,14-19,21-22H2,1H3
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160n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cells after 60 mins by scintillation counting analysis


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50401943
PNG
(CHEMBL2207642)
Show SMILES COc1ccccc1N1CCN(Cc2cc(CN3CCN(CC3)c3ccc(Cl)cc3)c3cccccc23)CC1
Show InChI InChI=1S/C33H37ClN4O/c1-39-33-10-6-5-9-32(33)38-21-17-36(18-22-38)25-27-23-26(30-7-3-2-4-8-31(27)30)24-35-15-19-37(20-16-35)29-13-11-28(34)12-14-29/h2-14,23H,15-22,24-25H2,1H3
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160n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2short receptor expressed in CHO cells after 60 mins by scintillation counting analysis


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50401948
PNG
(CHEMBL2207637)
Show SMILES COc1ccccc1N1CCN(Cc2cc(CN(C)C)c3cccccc23)CC1
Show InChI InChI=1S/C25H31N3O/c1-26(2)18-20-17-21(23-10-6-4-5-9-22(20)23)19-27-13-15-28(16-14-27)24-11-7-8-12-25(24)29-3/h4-12,17H,13-16,18-19H2,1-3H3
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210n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2long receptor expressed in CHO cells after 60 mins by scintillation counting analysis


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50401951
PNG
(CHEMBL2207633)
Show SMILES COc1ccccc1N1CCN(Cc2cc(C#Cc3ccccc3)c3cccccc23)CC1
Show InChI InChI=1S/C30H28N2O/c1-33-30-15-9-8-14-29(30)32-20-18-31(19-21-32)23-26-22-25(17-16-24-10-4-2-5-11-24)27-12-6-3-7-13-28(26)27/h2-15,22H,18-21,23H2,1H3
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210n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cells after 60 mins by scintillation counting analysis


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50401946
PNG
(CHEMBL2207639)
Show SMILES COc1ccccc1N1CCN(Cc2cc(CN3CCOCC3)c3cccccc23)CC1
Show InChI InChI=1S/C27H33N3O2/c1-31-27-10-6-5-9-26(27)30-13-11-28(12-14-30)20-22-19-23(21-29-15-17-32-18-16-29)25-8-4-2-3-7-24(22)25/h2-10,19H,11-18,20-21H2,1H3
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350n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cells after 60 mins by scintillation counting analysis


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50401952
PNG
(CHEMBL2207632)
Show SMILES COc1ccccc1N1CCN(Cc2cc(C#C)c3cccccc23)CC1
Show InChI InChI=1S/C24H24N2O/c1-3-19-17-20(22-10-6-4-5-9-21(19)22)18-25-13-15-26(16-14-25)23-11-7-8-12-24(23)27-2/h1,4-12,17H,13-16,18H2,2H3
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370n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cells after 60 mins by scintillation counting analysis


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50401950
PNG
(CHEMBL2207634)
Show SMILES CCCC#Cc1cc(CN2CCN(CC2)c2ccccc2OC)c2cccccc12
Show InChI InChI=1S/C27H30N2O/c1-3-4-6-11-22-20-23(25-13-8-5-7-12-24(22)25)21-28-16-18-29(19-17-28)26-14-9-10-15-27(26)30-2/h5,7-10,12-15,20H,3-4,16-19,21H2,1-2H3
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370n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cells after 60 mins by scintillation counting analysis


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
5-HT2


(PIG)
BDBM50401954
PNG
(CHEMBL2207636)
Show SMILES COc1ccccc1N1CCN(Cc2cc(C#N)c3cccccc23)CC1
Show InChI InChI=1S/C23H23N3O/c1-27-23-10-6-5-9-22(23)26-13-11-25(12-14-26)17-19-15-18(16-24)20-7-3-2-4-8-21(19)20/h2-10,15H,11-14,17H2,1H3
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380n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5-HT2 receptor in porcine cerebral cortex homogenate after 60 mins by scintillation counting analysis


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50401948
PNG
(CHEMBL2207637)
Show SMILES COc1ccccc1N1CCN(Cc2cc(CN(C)C)c3cccccc23)CC1
Show InChI InChI=1S/C25H31N3O/c1-26(2)18-20-17-21(23-10-6-4-5-9-22(20)23)19-27-13-15-28(16-14-27)24-11-7-8-12-25(24)29-3/h4-12,17H,13-16,18-19H2,1-3H3
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390n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cells after 60 mins by scintillation counting analysis


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Sus scrofa)
BDBM50401954
PNG
(CHEMBL2207636)
Show SMILES COc1ccccc1N1CCN(Cc2cc(C#N)c3cccccc23)CC1
Show InChI InChI=1S/C23H23N3O/c1-27-23-10-6-5-9-22(23)26-13-11-25(12-14-26)17-19-15-18(16-24)20-7-3-2-4-8-21(19)20/h2-10,15H,11-14,17H2,1H3
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410n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50401945
PNG
(CHEMBL2207640)
Show SMILES COc1ccccc1N1CCN(Cc2cc(CN3CCN(C)CC3)c3cccccc23)CC1
Show InChI InChI=1S/C28H36N4O/c1-29-12-14-30(15-13-29)21-23-20-24(26-9-5-3-4-8-25(23)26)22-31-16-18-32(19-17-31)27-10-6-7-11-28(27)33-2/h3-11,20H,12-19,21-22H2,1-2H3
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460n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cells after 60 mins by scintillation counting analysis


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50401943
PNG
(CHEMBL2207642)
Show SMILES COc1ccccc1N1CCN(Cc2cc(CN3CCN(CC3)c3ccc(Cl)cc3)c3cccccc23)CC1
Show InChI InChI=1S/C33H37ClN4O/c1-39-33-10-6-5-9-32(33)38-21-17-36(18-22-38)25-27-23-26(30-7-3-2-4-8-31(27)30)24-35-15-19-37(20-16-35)29-13-11-28(34)12-14-29/h2-14,23H,15-22,24-25H2,1H3
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460n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]URDE257 from human histamine H2 receptor expressed in insect Sf9 cell membrane preparation after 60 mins by scintillation countin...


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50401943
PNG
(CHEMBL2207642)
Show SMILES COc1ccccc1N1CCN(Cc2cc(CN3CCN(CC3)c3ccc(Cl)cc3)c3cccccc23)CC1
Show InChI InChI=1S/C33H37ClN4O/c1-39-33-10-6-5-9-32(33)38-21-17-36(18-22-38)25-27-23-26(30-7-3-2-4-8-31(27)30)24-35-15-19-37(20-16-35)29-13-11-28(34)12-14-29/h2-14,23H,15-22,24-25H2,1H3
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490n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from human histamine H1 receptor expressed in insect Sf9 cell membrane preparation after 60 mins by scintillation coun...


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Sus scrofa)
BDBM50401953
PNG
(CHEMBL2207643)
Show SMILES COc1ccccc1N1CCN(Cc2ccc3cccccc23)CC1
Show InChI InChI=1S/C22H24N2O/c1-25-22-10-6-5-9-21(22)24-15-13-23(14-16-24)17-19-12-11-18-7-3-2-4-8-20(18)19/h2-12H,13-17H2,1H3
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500n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50401944
PNG
(CHEMBL2207641)
Show SMILES COc1ccccc1N1CCN(Cc2cc(CN3CCN(CC3)c3ccccc3OC)c3cccccc23)CC1
Show InChI InChI=1S/C34H40N4O2/c1-39-33-14-8-6-12-31(33)37-20-16-35(17-21-37)25-27-24-28(30-11-5-3-4-10-29(27)30)26-36-18-22-38(23-19-36)32-13-7-9-15-34(32)40-2/h3-15,24H,16-23,25-26H2,1-2H3
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530n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]URDE257 from human histamine H2 receptor expressed in insect Sf9 cell membrane preparation after 60 mins by scintillation countin...


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50401954
PNG
(CHEMBL2207636)
Show SMILES COc1ccccc1N1CCN(Cc2cc(C#N)c3cccccc23)CC1
Show InChI InChI=1S/C23H23N3O/c1-27-23-10-6-5-9-22(23)26-13-11-25(12-14-26)17-19-15-18(16-24)20-7-3-2-4-8-21(19)20/h2-10,15H,11-14,17H2,1H3
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530n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cells after 60 mins by scintillation counting analysis


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
5-HT2


(PIG)
BDBM50401944
PNG
(CHEMBL2207641)
Show SMILES COc1ccccc1N1CCN(Cc2cc(CN3CCN(CC3)c3ccccc3OC)c3cccccc23)CC1
Show InChI InChI=1S/C34H40N4O2/c1-39-33-14-8-6-12-31(33)37-20-16-35(17-21-37)25-27-24-28(30-11-5-3-4-10-29(27)30)26-36-18-22-38(23-19-36)32-13-7-9-15-34(32)40-2/h3-15,24H,16-23,25-26H2,1-2H3
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560n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5-HT2 receptor in porcine cerebral cortex homogenate after 60 mins by scintillation counting analysis


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50401949
PNG
(CHEMBL2207635)
Show SMILES COc1ccccc1N1CCN(Cc2cc(CO)c3cccccc23)CC1
Show InChI InChI=1S/C23H26N2O2/c1-27-23-10-6-5-9-22(23)25-13-11-24(12-14-25)16-18-15-19(17-26)21-8-4-2-3-7-20(18)21/h2-10,15,26H,11-14,16-17H2,1H3
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580n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cells after 60 mins by scintillation counting analysis


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Sus scrofa)
BDBM50401944
PNG
(CHEMBL2207641)
Show SMILES COc1ccccc1N1CCN(Cc2cc(CN3CCN(CC3)c3ccccc3OC)c3cccccc23)CC1
Show InChI InChI=1S/C34H40N4O2/c1-39-33-14-8-6-12-31(33)37-20-16-35(17-21-37)25-27-24-28(30-11-5-3-4-10-29(27)30)26-36-18-22-38(23-19-36)32-13-7-9-15-34(32)40-2/h3-15,24H,16-23,25-26H2,1-2H3
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740n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Sus scrofa)
BDBM50401949
PNG
(CHEMBL2207635)
Show SMILES COc1ccccc1N1CCN(Cc2cc(CO)c3cccccc23)CC1
Show InChI InChI=1S/C23H26N2O2/c1-27-23-10-6-5-9-22(23)25-13-11-24(12-14-25)16-18-15-19(17-26)21-8-4-2-3-7-20(18)21/h2-10,15,26H,11-14,16-17H2,1H3
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860n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
5-HT2


(PIG)
BDBM50401949
PNG
(CHEMBL2207635)
Show SMILES COc1ccccc1N1CCN(Cc2cc(CO)c3cccccc23)CC1
Show InChI InChI=1S/C23H26N2O2/c1-27-23-10-6-5-9-22(23)25-13-11-24(12-14-25)16-18-15-19(17-26)21-8-4-2-3-7-20(18)21/h2-10,15,26H,11-14,16-17H2,1H3
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990n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5-HT2 receptor in porcine cerebral cortex homogenate after 60 mins by scintillation counting analysis


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50401943
PNG
(CHEMBL2207642)
Show SMILES COc1ccccc1N1CCN(Cc2cc(CN3CCN(CC3)c3ccc(Cl)cc3)c3cccccc23)CC1
Show InChI InChI=1S/C33H37ClN4O/c1-39-33-10-6-5-9-32(33)38-21-17-36(18-22-38)25-27-23-26(30-7-3-2-4-8-31(27)30)24-35-15-19-37(20-16-35)29-13-11-28(34)12-14-29/h2-14,23H,15-22,24-25H2,1H3
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>1.00E+3n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]UR-PI294 from human histamine H4 receptor expressed in insect Sf9 cell membrane preparation after 60 mins by scintillation counti...


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50401944
PNG
(CHEMBL2207641)
Show SMILES COc1ccccc1N1CCN(Cc2cc(CN3CCN(CC3)c3ccccc3OC)c3cccccc23)CC1
Show InChI InChI=1S/C34H40N4O2/c1-39-33-14-8-6-12-31(33)37-20-16-35(17-21-37)25-27-24-28(30-11-5-3-4-10-29(27)30)26-36-18-22-38(23-19-36)32-13-7-9-15-34(32)40-2/h3-15,24H,16-23,25-26H2,1-2H3
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1.00E+3n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from human histamine H1 receptor expressed in insect Sf9 cell membrane preparation after 60 mins by scintillation coun...


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
5-HT2


(PIG)
BDBM50401951
PNG
(CHEMBL2207633)
Show SMILES COc1ccccc1N1CCN(Cc2cc(C#Cc3ccccc3)c3cccccc23)CC1
Show InChI InChI=1S/C30H28N2O/c1-33-30-15-9-8-14-29(30)32-20-18-31(19-21-32)23-26-22-25(17-16-24-10-4-2-5-11-24)27-12-6-3-7-13-28(26)27/h2-15,22H,18-21,23H2,1H3
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1.00E+3n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5-HT2 receptor in porcine cerebral cortex homogenate after 60 mins by scintillation counting analysis


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
5-HT2


(PIG)
BDBM50401946
PNG
(CHEMBL2207639)
Show SMILES COc1ccccc1N1CCN(Cc2cc(CN3CCOCC3)c3cccccc23)CC1
Show InChI InChI=1S/C27H33N3O2/c1-31-27-10-6-5-9-26(27)30-13-11-28(12-14-30)20-22-19-23(21-29-15-17-32-18-16-29)25-8-4-2-3-7-24(22)25/h2-10,19H,11-18,20-21H2,1H3
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1.00E+3n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5-HT2 receptor in porcine cerebral cortex homogenate after 60 mins by scintillation counting analysis


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Sus scrofa)
BDBM50401943
PNG
(CHEMBL2207642)
Show SMILES COc1ccccc1N1CCN(Cc2cc(CN3CCN(CC3)c3ccc(Cl)cc3)c3cccccc23)CC1
Show InChI InChI=1S/C33H37ClN4O/c1-39-33-10-6-5-9-32(33)38-21-17-36(18-22-38)25-27-23-26(30-7-3-2-4-8-31(27)30)24-35-15-19-37(20-16-35)29-13-11-28(34)12-14-29/h2-14,23H,15-22,24-25H2,1H3
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1.10E+3n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
5-HT2


(PIG)
BDBM50401950
PNG
(CHEMBL2207634)
Show SMILES CCCC#Cc1cc(CN2CCN(CC2)c2ccccc2OC)c2cccccc12
Show InChI InChI=1S/C27H30N2O/c1-3-4-6-11-22-20-23(25-13-8-5-7-12-24(22)25)21-28-16-18-29(19-17-28)26-14-9-10-15-27(26)30-2/h5,7-10,12-15,20H,3-4,16-19,21H2,1-2H3
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1.30E+3n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5-HT2 receptor in porcine cerebral cortex homogenate after 60 mins by scintillation counting analysis


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
5-HT2


(PIG)
BDBM50401947
PNG
(CHEMBL2207638)
Show SMILES COc1ccccc1N1CCN(Cc2cc(CN3CCCCC3)c3cccccc23)CC1
Show InChI InChI=1S/C28H35N3O/c1-32-28-13-7-6-12-27(28)31-18-16-30(17-19-31)22-24-20-23(21-29-14-8-3-9-15-29)25-10-4-2-5-11-26(24)25/h2,4-7,10-13,20H,3,8-9,14-19,21-22H2,1H3
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1.30E+3n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5-HT2 receptor in porcine cerebral cortex homogenate after 60 mins by scintillation counting analysis


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Sus scrofa)
BDBM50401951
PNG
(CHEMBL2207633)
Show SMILES COc1ccccc1N1CCN(Cc2cc(C#Cc3ccccc3)c3cccccc23)CC1
Show InChI InChI=1S/C30H28N2O/c1-33-30-15-9-8-14-29(30)32-20-18-31(19-21-32)23-26-22-25(17-16-24-10-4-2-5-11-24)27-12-6-3-7-13-28(26)27/h2-15,22H,18-21,23H2,1H3
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1.30E+3n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50401949
PNG
(CHEMBL2207635)
Show SMILES COc1ccccc1N1CCN(Cc2cc(CO)c3cccccc23)CC1
Show InChI InChI=1S/C23H26N2O2/c1-27-23-10-6-5-9-22(23)25-13-11-24(12-14-25)16-18-15-19(17-26)21-8-4-2-3-7-20(18)21/h2-10,15,26H,11-14,16-17H2,1H3
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1.40E+3n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from human histamine H1 receptor expressed in insect Sf9 cell membrane preparation after 60 mins by scintillation coun...


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Sus scrofa)
BDBM50401950
PNG
(CHEMBL2207634)
Show SMILES CCCC#Cc1cc(CN2CCN(CC2)c2ccccc2OC)c2cccccc12
Show InChI InChI=1S/C27H30N2O/c1-3-4-6-11-22-20-23(25-13-8-5-7-12-24(22)25)21-28-16-18-29(19-17-28)26-14-9-10-15-27(26)30-2/h5,7-10,12-15,20H,3-4,16-19,21H2,1-2H3
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1.40E+3n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
5-HT2


(PIG)
BDBM50401943
PNG
(CHEMBL2207642)
Show SMILES COc1ccccc1N1CCN(Cc2cc(CN3CCN(CC3)c3ccc(Cl)cc3)c3cccccc23)CC1
Show InChI InChI=1S/C33H37ClN4O/c1-39-33-10-6-5-9-32(33)38-21-17-36(18-22-38)25-27-23-26(30-7-3-2-4-8-31(27)30)24-35-15-19-37(20-16-35)29-13-11-28(34)12-14-29/h2-14,23H,15-22,24-25H2,1H3
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1.60E+3n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5-HT2 receptor in porcine cerebral cortex homogenate after 60 mins by scintillation counting analysis


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
5-HT2


(PIG)
BDBM50401948
PNG
(CHEMBL2207637)
Show SMILES COc1ccccc1N1CCN(Cc2cc(CN(C)C)c3cccccc23)CC1
Show InChI InChI=1S/C25H31N3O/c1-26(2)18-20-17-21(23-10-6-4-5-9-22(20)23)19-27-13-15-28(16-14-27)24-11-7-8-12-25(24)29-3/h4-12,17H,13-16,18-19H2,1-3H3
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1.80E+3n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5-HT2 receptor in porcine cerebral cortex homogenate after 60 mins by scintillation counting analysis


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
5-HT2


(PIG)
BDBM50401945
PNG
(CHEMBL2207640)
Show SMILES COc1ccccc1N1CCN(Cc2cc(CN3CCN(C)CC3)c3cccccc23)CC1
Show InChI InChI=1S/C28H36N4O/c1-29-12-14-30(15-13-29)21-23-20-24(26-9-5-3-4-8-25(23)26)22-31-16-18-32(19-17-31)27-10-6-7-11-28(27)33-2/h3-11,20H,12-19,21-22H2,1-2H3
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2.10E+3n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5-HT2 receptor in porcine cerebral cortex homogenate after 60 mins by scintillation counting analysis


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
5-HT2


(PIG)
BDBM50401952
PNG
(CHEMBL2207632)
Show SMILES COc1ccccc1N1CCN(Cc2cc(C#C)c3cccccc23)CC1
Show InChI InChI=1S/C24H24N2O/c1-3-19-17-20(22-10-6-4-5-9-21(19)22)18-25-13-15-26(16-14-25)23-11-7-8-12-24(23)27-2/h1,4-12,17H,13-16,18H2,2H3
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2.10E+3n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5-HT2 receptor in porcine cerebral cortex homogenate after 60 mins by scintillation counting analysis


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50401948
PNG
(CHEMBL2207637)
Show SMILES COc1ccccc1N1CCN(Cc2cc(CN(C)C)c3cccccc23)CC1
Show InChI InChI=1S/C25H31N3O/c1-26(2)18-20-17-21(23-10-6-4-5-9-22(20)23)19-27-13-15-28(16-14-27)24-11-7-8-12-25(24)29-3/h4-12,17H,13-16,18-19H2,1-3H3
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2.60E+3n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from human histamine H1 receptor expressed in insect Sf9 cell membrane preparation after 60 mins by scintillation coun...


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50401948
PNG
(CHEMBL2207637)
Show SMILES COc1ccccc1N1CCN(Cc2cc(CN(C)C)c3cccccc23)CC1
Show InChI InChI=1S/C25H31N3O/c1-26(2)18-20-17-21(23-10-6-4-5-9-22(20)23)19-27-13-15-28(16-14-27)24-11-7-8-12-25(24)29-3/h4-12,17H,13-16,18-19H2,1-3H3
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3.20E+3n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]URDE257 from human histamine H2 receptor expressed in insect Sf9 cell membrane preparation after 60 mins by scintillation countin...


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Sus scrofa)
BDBM50401947
PNG
(CHEMBL2207638)
Show SMILES COc1ccccc1N1CCN(Cc2cc(CN3CCCCC3)c3cccccc23)CC1
Show InChI InChI=1S/C28H35N3O/c1-32-28-13-7-6-12-27(28)31-18-16-30(17-19-31)22-24-20-23(21-29-14-8-3-9-15-29)25-10-4-2-5-11-26(24)25/h2,4-7,10-13,20H,3,8-9,14-19,21-22H2,1H3
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4.10E+3n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50401947
PNG
(CHEMBL2207638)
Show SMILES COc1ccccc1N1CCN(Cc2cc(CN3CCCCC3)c3cccccc23)CC1
Show InChI InChI=1S/C28H35N3O/c1-32-28-13-7-6-12-27(28)31-18-16-30(17-19-31)22-24-20-23(21-29-14-8-3-9-15-29)25-10-4-2-5-11-26(24)25/h2,4-7,10-13,20H,3,8-9,14-19,21-22H2,1H3
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4.20E+3n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]URDE257 from human histamine H2 receptor expressed in insect Sf9 cell membrane preparation after 60 mins by scintillation countin...


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Sus scrofa)
BDBM50401948
PNG
(CHEMBL2207637)
Show SMILES COc1ccccc1N1CCN(Cc2cc(CN(C)C)c3cccccc23)CC1
Show InChI InChI=1S/C25H31N3O/c1-26(2)18-20-17-21(23-10-6-4-5-9-22(20)23)19-27-13-15-28(16-14-27)24-11-7-8-12-25(24)29-3/h4-12,17H,13-16,18-19H2,1-3H3
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4.50E+3n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Sus scrofa)
BDBM50401946
PNG
(CHEMBL2207639)
Show SMILES COc1ccccc1N1CCN(Cc2cc(CN3CCOCC3)c3cccccc23)CC1
Show InChI InChI=1S/C27H33N3O2/c1-31-27-10-6-5-9-26(27)30-13-11-28(12-14-30)20-22-19-23(21-29-15-17-32-18-16-29)25-8-4-2-3-7-24(22)25/h2-10,19H,11-18,20-21H2,1H3
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5.00E+3n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50401947
PNG
(CHEMBL2207638)
Show SMILES COc1ccccc1N1CCN(Cc2cc(CN3CCCCC3)c3cccccc23)CC1
Show InChI InChI=1S/C28H35N3O/c1-32-28-13-7-6-12-27(28)31-18-16-30(17-19-31)22-24-20-23(21-29-14-8-3-9-15-29)25-10-4-2-5-11-26(24)25/h2,4-7,10-13,20H,3,8-9,14-19,21-22H2,1H3
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5.50E+3n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from human histamine H1 receptor expressed in insect Sf9 cell membrane preparation after 60 mins by scintillation coun...


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50401945
PNG
(CHEMBL2207640)
Show SMILES COc1ccccc1N1CCN(Cc2cc(CN3CCN(C)CC3)c3cccccc23)CC1
Show InChI InChI=1S/C28H36N4O/c1-29-12-14-30(15-13-29)21-23-20-24(26-9-5-3-4-8-25(23)26)22-31-16-18-32(19-17-31)27-10-6-7-11-28(27)33-2/h3-11,20H,12-19,21-22H2,1-2H3
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5.50E+3n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]URDE257 from human histamine H2 receptor expressed in insect Sf9 cell membrane preparation after 60 mins by scintillation countin...


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50401945
PNG
(CHEMBL2207640)
Show SMILES COc1ccccc1N1CCN(Cc2cc(CN3CCN(C)CC3)c3cccccc23)CC1
Show InChI InChI=1S/C28H36N4O/c1-29-12-14-30(15-13-29)21-23-20-24(26-9-5-3-4-8-25(23)26)22-31-16-18-32(19-17-31)27-10-6-7-11-28(27)33-2/h3-11,20H,12-19,21-22H2,1-2H3
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5.50E+3n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]Nalpha-methylhistamine from human histamine H3 receptor expressed in insect Sf9 cell membrane preparation after 60 mins by scinti...


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50401946
PNG
(CHEMBL2207639)
Show SMILES COc1ccccc1N1CCN(Cc2cc(CN3CCOCC3)c3cccccc23)CC1
Show InChI InChI=1S/C27H33N3O2/c1-31-27-10-6-5-9-26(27)30-13-11-28(12-14-30)20-22-19-23(21-29-15-17-32-18-16-29)25-8-4-2-3-7-24(22)25/h2-10,19H,11-18,20-21H2,1H3
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6.10E+3n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]URDE257 from human histamine H2 receptor expressed in insect Sf9 cell membrane preparation after 60 mins by scintillation countin...


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Sus scrofa)
BDBM50401952
PNG
(CHEMBL2207632)
Show SMILES COc1ccccc1N1CCN(Cc2cc(C#C)c3cccccc23)CC1
Show InChI InChI=1S/C24H24N2O/c1-3-19-17-20(22-10-6-4-5-9-21(19)22)18-25-13-15-26(16-14-25)23-11-7-8-12-24(23)27-2/h1,4-12,17H,13-16,18H2,2H3
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6.40E+3n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Sus scrofa)
BDBM50401945
PNG
(CHEMBL2207640)
Show SMILES COc1ccccc1N1CCN(Cc2cc(CN3CCN(C)CC3)c3cccccc23)CC1
Show InChI InChI=1S/C28H36N4O/c1-29-12-14-30(15-13-29)21-23-20-24(26-9-5-3-4-8-25(23)26)22-31-16-18-32(19-17-31)27-10-6-7-11-28(27)33-2/h3-11,20H,12-19,21-22H2,1-2H3
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6.40E+3n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50401946
PNG
(CHEMBL2207639)
Show SMILES COc1ccccc1N1CCN(Cc2cc(CN3CCOCC3)c3cccccc23)CC1
Show InChI InChI=1S/C27H33N3O2/c1-31-27-10-6-5-9-26(27)30-13-11-28(12-14-30)20-22-19-23(21-29-15-17-32-18-16-29)25-8-4-2-3-7-24(22)25/h2-10,19H,11-18,20-21H2,1H3
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6.50E+3n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from human histamine H1 receptor expressed in insect Sf9 cell membrane preparation after 60 mins by scintillation coun...


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50401949
PNG
(CHEMBL2207635)
Show SMILES COc1ccccc1N1CCN(Cc2cc(CO)c3cccccc23)CC1
Show InChI InChI=1S/C23H26N2O2/c1-27-23-10-6-5-9-22(23)25-13-11-24(12-14-25)16-18-15-19(17-26)21-8-4-2-3-7-20(18)21/h2-10,15,26H,11-14,16-17H2,1H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]UR-PI294 from human histamine H4 receptor expressed in insect Sf9 cell membrane preparation after 60 mins by scintillation counti...


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50401944
PNG
(CHEMBL2207641)
Show SMILES COc1ccccc1N1CCN(Cc2cc(CN3CCN(CC3)c3ccccc3OC)c3cccccc23)CC1
Show InChI InChI=1S/C34H40N4O2/c1-39-33-14-8-6-12-31(33)37-20-16-35(17-21-37)25-27-24-28(30-11-5-3-4-10-29(27)30)26-36-18-22-38(23-19-36)32-13-7-9-15-34(32)40-2/h3-15,24H,16-23,25-26H2,1-2H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]Nalpha-methylhistamine from human histamine H3 receptor expressed in insect Sf9 cell membrane preparation after 60 mins by scinti...


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50401948
PNG
(CHEMBL2207637)
Show SMILES COc1ccccc1N1CCN(Cc2cc(CN(C)C)c3cccccc23)CC1
Show InChI InChI=1S/C25H31N3O/c1-26(2)18-20-17-21(23-10-6-4-5-9-22(20)23)19-27-13-15-28(16-14-27)24-11-7-8-12-25(24)29-3/h4-12,17H,13-16,18-19H2,1-3H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]Nalpha-methylhistamine from human histamine H3 receptor expressed in insect Sf9 cell membrane preparation after 60 mins by scinti...


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50401943
PNG
(CHEMBL2207642)
Show SMILES COc1ccccc1N1CCN(Cc2cc(CN3CCN(CC3)c3ccc(Cl)cc3)c3cccccc23)CC1
Show InChI InChI=1S/C33H37ClN4O/c1-39-33-10-6-5-9-32(33)38-21-17-36(18-22-38)25-27-23-26(30-7-3-2-4-8-31(27)30)24-35-15-19-37(20-16-35)29-13-11-28(34)12-14-29/h2-14,23H,15-22,24-25H2,1H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]Nalpha-methylhistamine from human histamine H3 receptor expressed in insect Sf9 cell membrane preparation after 60 mins by scinti...


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50401949
PNG
(CHEMBL2207635)
Show SMILES COc1ccccc1N1CCN(Cc2cc(CO)c3cccccc23)CC1
Show InChI InChI=1S/C23H26N2O2/c1-27-23-10-6-5-9-22(23)25-13-11-24(12-14-25)16-18-15-19(17-26)21-8-4-2-3-7-20(18)21/h2-10,15,26H,11-14,16-17H2,1H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]URDE257 from human histamine H2 receptor expressed in insect Sf9 cell membrane preparation after 60 mins by scintillation countin...


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50401946
PNG
(CHEMBL2207639)
Show SMILES COc1ccccc1N1CCN(Cc2cc(CN3CCOCC3)c3cccccc23)CC1
Show InChI InChI=1S/C27H33N3O2/c1-31-27-10-6-5-9-26(27)30-13-11-28(12-14-30)20-22-19-23(21-29-15-17-32-18-16-29)25-8-4-2-3-7-24(22)25/h2-10,19H,11-18,20-21H2,1H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]UR-PI294 from human histamine H4 receptor expressed in insect Sf9 cell membrane preparation after 60 mins by scintillation counti...


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50401948
PNG
(CHEMBL2207637)
Show SMILES COc1ccccc1N1CCN(Cc2cc(CN(C)C)c3cccccc23)CC1
Show InChI InChI=1S/C25H31N3O/c1-26(2)18-20-17-21(23-10-6-4-5-9-22(20)23)19-27-13-15-28(16-14-27)24-11-7-8-12-25(24)29-3/h4-12,17H,13-16,18-19H2,1-3H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]UR-PI294 from human histamine H4 receptor expressed in insect Sf9 cell membrane preparation after 60 mins by scintillation counti...


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50401949
PNG
(CHEMBL2207635)
Show SMILES COc1ccccc1N1CCN(Cc2cc(CO)c3cccccc23)CC1
Show InChI InChI=1S/C23H26N2O2/c1-27-23-10-6-5-9-22(23)25-13-11-24(12-14-25)16-18-15-19(17-26)21-8-4-2-3-7-20(18)21/h2-10,15,26H,11-14,16-17H2,1H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]Nalpha-methylhistamine from human histamine H3 receptor expressed in insect Sf9 cell membrane preparation after 60 mins by scinti...


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50401944
PNG
(CHEMBL2207641)
Show SMILES COc1ccccc1N1CCN(Cc2cc(CN3CCN(CC3)c3ccccc3OC)c3cccccc23)CC1
Show InChI InChI=1S/C34H40N4O2/c1-39-33-14-8-6-12-31(33)37-20-16-35(17-21-37)25-27-24-28(30-11-5-3-4-10-29(27)30)26-36-18-22-38(23-19-36)32-13-7-9-15-34(32)40-2/h3-15,24H,16-23,25-26H2,1-2H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]UR-PI294 from human histamine H4 receptor expressed in insect Sf9 cell membrane preparation after 60 mins by scintillation counti...


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50401946
PNG
(CHEMBL2207639)
Show SMILES COc1ccccc1N1CCN(Cc2cc(CN3CCOCC3)c3cccccc23)CC1
Show InChI InChI=1S/C27H33N3O2/c1-31-27-10-6-5-9-26(27)30-13-11-28(12-14-30)20-22-19-23(21-29-15-17-32-18-16-29)25-8-4-2-3-7-24(22)25/h2-10,19H,11-18,20-21H2,1H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]Nalpha-methylhistamine from human histamine H3 receptor expressed in insect Sf9 cell membrane preparation after 60 mins by scinti...


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50401947
PNG
(CHEMBL2207638)
Show SMILES COc1ccccc1N1CCN(Cc2cc(CN3CCCCC3)c3cccccc23)CC1
Show InChI InChI=1S/C28H35N3O/c1-32-28-13-7-6-12-27(28)31-18-16-30(17-19-31)22-24-20-23(21-29-14-8-3-9-15-29)25-10-4-2-5-11-26(24)25/h2,4-7,10-13,20H,3,8-9,14-19,21-22H2,1H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]Nalpha-methylhistamine from human histamine H3 receptor expressed in insect Sf9 cell membrane preparation after 60 mins by scinti...


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50401945
PNG
(CHEMBL2207640)
Show SMILES COc1ccccc1N1CCN(Cc2cc(CN3CCN(C)CC3)c3cccccc23)CC1
Show InChI InChI=1S/C28H36N4O/c1-29-12-14-30(15-13-29)21-23-20-24(26-9-5-3-4-8-25(23)26)22-31-16-18-32(19-17-31)27-10-6-7-11-28(27)33-2/h3-11,20H,12-19,21-22H2,1-2H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]mepyramine from human histamine H1 receptor expressed in insect Sf9 cell membrane preparation after 60 mins by scintillation coun...


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50401945
PNG
(CHEMBL2207640)
Show SMILES COc1ccccc1N1CCN(Cc2cc(CN3CCN(C)CC3)c3cccccc23)CC1
Show InChI InChI=1S/C28H36N4O/c1-29-12-14-30(15-13-29)21-23-20-24(26-9-5-3-4-8-25(23)26)22-31-16-18-32(19-17-31)27-10-6-7-11-28(27)33-2/h3-11,20H,12-19,21-22H2,1-2H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]UR-PI294 from human histamine H4 receptor expressed in insect Sf9 cell membrane preparation after 60 mins by scintillation counti...


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50401947
PNG
(CHEMBL2207638)
Show SMILES COc1ccccc1N1CCN(Cc2cc(CN3CCCCC3)c3cccccc23)CC1
Show InChI InChI=1S/C28H35N3O/c1-32-28-13-7-6-12-27(28)31-18-16-30(17-19-31)22-24-20-23(21-29-14-8-3-9-15-29)25-10-4-2-5-11-26(24)25/h2,4-7,10-13,20H,3,8-9,14-19,21-22H2,1H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]UR-PI294 from human histamine H4 receptor expressed in insect Sf9 cell membrane preparation after 60 mins by scintillation counti...


Bioorg Med Chem Lett 22: 7151-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.064
BindingDB Entry DOI: 10.7270/Q2Q52QSM
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%