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PubMed code 23117174

Compile data set for download or QSAR
Found 74 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50402166
PNG
(CHEMBL2207988)
Show SMILES Cc1csc(n1)-c1[nH]cnc1-c1ccc2ncsc2c1
Show InChI InChI=1S/C14H10N4S2/c1-8-5-19-14(18-8)13-12(15-6-16-13)9-2-3-10-11(4-9)20-7-17-10/h2-7H,1H3,(H,15,16)
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n/an/a 2.70n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISA

Bioorg Med Chem 20: 7128-38 (2012)


Article DOI: 10.1016/j.bmc.2012.09.066
BindingDB Entry DOI: 10.7270/Q2542PQ0
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50402175
PNG
(CHEMBL2208016)
Show SMILES CCOC(=O)NCc1nc(c([nH]1)-c1nc(C)cs1)-c1ccc2ncsc2c1
Show InChI InChI=1S/C18H17N5O2S2/c1-3-25-18(24)19-7-14-22-15(16(23-14)17-21-10(2)8-26-17)11-4-5-12-13(6-11)27-9-20-12/h4-6,8-9H,3,7H2,1-2H3,(H,19,24)(H,22,23)
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n/an/a 4.5n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISA

Bioorg Med Chem 20: 7128-38 (2012)


Article DOI: 10.1016/j.bmc.2012.09.066
BindingDB Entry DOI: 10.7270/Q2542PQ0
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50402168
PNG
(CHEMBL2208237)
Show SMILES CC(C)COC(=O)NCc1nc(c([nH]1)-c1nc(C)cs1)-c1ccc2ncsc2c1
Show InChI InChI=1S/C20H21N5O2S2/c1-11(2)8-27-20(26)21-7-16-24-17(18(25-16)19-23-12(3)9-28-19)13-4-5-14-15(6-13)29-10-22-14/h4-6,9-11H,7-8H2,1-3H3,(H,21,26)(H,24,25)
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n/an/a 5.5n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISA

Bioorg Med Chem 20: 7128-38 (2012)


Article DOI: 10.1016/j.bmc.2012.09.066
BindingDB Entry DOI: 10.7270/Q2542PQ0
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50402158
PNG
(CHEMBL2207996)
Show SMILES Cc1csc(n1)-c1[nH]c(nc1-c1ccc2ncsc2c1)C(F)(F)F
Show InChI InChI=1S/C15H9F3N4S2/c1-7-5-23-13(20-7)12-11(21-14(22-12)15(16,17)18)8-2-3-9-10(4-8)24-6-19-9/h2-6H,1H3,(H,21,22)
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Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISA

Bioorg Med Chem 20: 7128-38 (2012)


Article DOI: 10.1016/j.bmc.2012.09.066
BindingDB Entry DOI: 10.7270/Q2542PQ0
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50402165
PNG
(CHEMBL2207989)
Show SMILES Cc1csc(n1)-c1[nH]c(C)nc1-c1ccc2ncsc2c1
Show InChI InChI=1S/C15H12N4S2/c1-8-6-20-15(17-8)14-13(18-9(2)19-14)10-3-4-11-12(5-10)21-7-16-11/h3-7H,1-2H3,(H,18,19)
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n/an/a 5.80n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISA

Bioorg Med Chem 20: 7128-38 (2012)


Article DOI: 10.1016/j.bmc.2012.09.066
BindingDB Entry DOI: 10.7270/Q2542PQ0
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50402159
PNG
(CHEMBL2207995)
Show SMILES CCCCCCc1nc(c([nH]1)-c1nc(C)cs1)-c1ccc2ncsc2c1
Show InChI InChI=1S/C20H22N4S2/c1-3-4-5-6-7-17-23-18(19(24-17)20-22-13(2)11-25-20)14-8-9-15-16(10-14)26-12-21-15/h8-12H,3-7H2,1-2H3,(H,23,24)
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n/an/a 7n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISA

Bioorg Med Chem 20: 7128-38 (2012)


Article DOI: 10.1016/j.bmc.2012.09.066
BindingDB Entry DOI: 10.7270/Q2542PQ0
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50402144
PNG
(CHEMBL2208011)
Show SMILES CCNC(=O)OCc1nc(c([nH]1)-c1nc(C)cs1)-c1ccc2ncsc2c1
Show InChI InChI=1S/C18H17N5O2S2/c1-3-19-18(24)25-7-14-22-15(16(23-14)17-21-10(2)8-26-17)11-4-5-12-13(6-11)27-9-20-12/h4-6,8-9H,3,7H2,1-2H3,(H,19,24)(H,22,23)
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n/an/a 7.20n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISA

Bioorg Med Chem 20: 7128-38 (2012)


Article DOI: 10.1016/j.bmc.2012.09.066
BindingDB Entry DOI: 10.7270/Q2542PQ0
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50402172
PNG
(CHEMBL2208019)
Show SMILES CCCOC(=O)NCc1nc(c([nH]1)-c1nc(C)cs1)-c1ccc2ncsc2c1
Show InChI InChI=1S/C19H19N5O2S2/c1-3-6-26-19(25)20-8-15-23-16(17(24-15)18-22-11(2)9-27-18)12-4-5-13-14(7-12)28-10-21-13/h4-5,7,9-10H,3,6,8H2,1-2H3,(H,20,25)(H,23,24)
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n/an/a 7.30n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISA

Bioorg Med Chem 20: 7128-38 (2012)


Article DOI: 10.1016/j.bmc.2012.09.066
BindingDB Entry DOI: 10.7270/Q2542PQ0
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50402173
PNG
(CHEMBL2208018)
Show SMILES COC(=O)NCc1nc(c([nH]1)-c1nc(C)cs1)-c1ccc2ncsc2c1
Show InChI InChI=1S/C17H15N5O2S2/c1-9-7-25-16(20-9)15-14(21-13(22-15)6-18-17(23)24-2)10-3-4-11-12(5-10)26-8-19-11/h3-5,7-8H,6H2,1-2H3,(H,18,23)(H,21,22)
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n/an/a 7.70n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISA

Bioorg Med Chem 20: 7128-38 (2012)


Article DOI: 10.1016/j.bmc.2012.09.066
BindingDB Entry DOI: 10.7270/Q2542PQ0
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50402174
PNG
(CHEMBL2208017)
Show SMILES Cc1csc(n1)-c1[nH]c(CN2CCOC2=O)nc1-c1ccc2ncsc2c1
Show InChI InChI=1S/C18H15N5O2S2/c1-10-8-26-17(20-10)16-15(11-2-3-12-13(6-11)27-9-19-12)21-14(22-16)7-23-4-5-25-18(23)24/h2-3,6,8-9H,4-5,7H2,1H3,(H,21,22)
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n/an/a 8.10n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISA

Bioorg Med Chem 20: 7128-38 (2012)


Article DOI: 10.1016/j.bmc.2012.09.066
BindingDB Entry DOI: 10.7270/Q2542PQ0
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50402163
PNG
(CHEMBL2207991)
Show SMILES CCCc1nc(c([nH]1)-c1nc(C)cs1)-c1ccc2ncsc2c1
Show InChI InChI=1S/C17H16N4S2/c1-3-4-14-20-15(16(21-14)17-19-10(2)8-22-17)11-5-6-12-13(7-11)23-9-18-12/h5-9H,3-4H2,1-2H3,(H,20,21)
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Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISA

Bioorg Med Chem 20: 7128-38 (2012)


Article DOI: 10.1016/j.bmc.2012.09.066
BindingDB Entry DOI: 10.7270/Q2542PQ0
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50402162
PNG
(CHEMBL2207992)
Show SMILES CC(C)c1nc(c([nH]1)-c1nc(C)cs1)-c1ccc2ncsc2c1
Show InChI InChI=1S/C17H16N4S2/c1-9(2)16-20-14(15(21-16)17-19-10(3)7-22-17)11-4-5-12-13(6-11)23-8-18-12/h4-9H,1-3H3,(H,20,21)
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n/an/a 8.20n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISA

Bioorg Med Chem 20: 7128-38 (2012)


Article DOI: 10.1016/j.bmc.2012.09.066
BindingDB Entry DOI: 10.7270/Q2542PQ0
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50402145
PNG
(CHEMBL2208010)
Show SMILES Cc1csc(n1)-c1[nH]c(CCCCC(N)=O)nc1-c1ccc2ncsc2c1
Show InChI InChI=1S/C19H19N5OS2/c1-11-9-26-19(22-11)18-17(12-6-7-13-14(8-12)27-10-21-13)23-16(24-18)5-3-2-4-15(20)25/h6-10H,2-5H2,1H3,(H2,20,25)(H,23,24)
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n/an/a 8.30n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISA

Bioorg Med Chem 20: 7128-38 (2012)


Article DOI: 10.1016/j.bmc.2012.09.066
BindingDB Entry DOI: 10.7270/Q2542PQ0
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50402169
PNG
(CHEMBL2208022)
Show SMILES CC(C)OC(=O)NCc1nc(c([nH]1)-c1nc(C)cs1)-c1ccc2ncsc2c1
Show InChI InChI=1S/C19H19N5O2S2/c1-10(2)26-19(25)20-7-15-23-16(17(24-15)18-22-11(3)8-27-18)12-4-5-13-14(6-12)28-9-21-13/h4-6,8-10H,7H2,1-3H3,(H,20,25)(H,23,24)
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n/an/a 8.60n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISA

Bioorg Med Chem 20: 7128-38 (2012)


Article DOI: 10.1016/j.bmc.2012.09.066
BindingDB Entry DOI: 10.7270/Q2542PQ0
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50402156
PNG
(CHEMBL2207998)
Show SMILES Cc1csc(n1)-c1[nH]c(nc1-c1ccc2ncsc2c1)C1CCCC1
Show InChI InChI=1S/C19H18N4S2/c1-11-9-24-19(21-11)17-16(22-18(23-17)12-4-2-3-5-12)13-6-7-14-15(8-13)25-10-20-14/h6-10,12H,2-5H2,1H3,(H,22,23)
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Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISA

Bioorg Med Chem 20: 7128-38 (2012)


Article DOI: 10.1016/j.bmc.2012.09.066
BindingDB Entry DOI: 10.7270/Q2542PQ0
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50402166
PNG
(CHEMBL2207988)
Show SMILES Cc1csc(n1)-c1[nH]cnc1-c1ccc2ncsc2c1
Show InChI InChI=1S/C14H10N4S2/c1-8-5-19-14(18-8)13-12(15-6-16-13)9-2-3-10-11(4-9)20-7-17-10/h2-7H,1H3,(H,15,16)
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Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of ALK5-mediated TNFalpha-induced Smad2/3 phosphorylation in human A549 cells preincubated for 2 hrs before addition of TNFalpha after 1 h...

Bioorg Med Chem 20: 7128-38 (2012)


Article DOI: 10.1016/j.bmc.2012.09.066
BindingDB Entry DOI: 10.7270/Q2542PQ0
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50402157
PNG
(CHEMBL2207997)
Show SMILES Cc1csc(n1)-c1[nH]c(nc1-c1ccc2ncsc2c1)C1CC1
Show InChI InChI=1S/C17H14N4S2/c1-9-7-22-17(19-9)15-14(20-16(21-15)10-2-3-10)11-4-5-12-13(6-11)23-8-18-12/h4-8,10H,2-3H2,1H3,(H,20,21)
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Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISA

Bioorg Med Chem 20: 7128-38 (2012)


Article DOI: 10.1016/j.bmc.2012.09.066
BindingDB Entry DOI: 10.7270/Q2542PQ0
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50402161
PNG
(CHEMBL2207993)
Show SMILES CC(C)Cc1nc(c([nH]1)-c1nc(C)cs1)-c1ccc2ncsc2c1
Show InChI InChI=1S/C18H18N4S2/c1-10(2)6-15-21-16(17(22-15)18-20-11(3)8-23-18)12-4-5-13-14(7-12)24-9-19-13/h4-5,7-10H,6H2,1-3H3,(H,21,22)
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n/an/a 9n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISA

Bioorg Med Chem 20: 7128-38 (2012)


Article DOI: 10.1016/j.bmc.2012.09.066
BindingDB Entry DOI: 10.7270/Q2542PQ0
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50402164
PNG
(CHEMBL2207990)
Show SMILES CCc1nc(c([nH]1)-c1nc(C)cs1)-c1ccc2ncsc2c1
Show InChI InChI=1S/C16H14N4S2/c1-3-13-19-14(15(20-13)16-18-9(2)7-21-16)10-4-5-11-12(6-10)22-8-17-11/h4-8H,3H2,1-2H3,(H,19,20)
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Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISA

Bioorg Med Chem 20: 7128-38 (2012)


Article DOI: 10.1016/j.bmc.2012.09.066
BindingDB Entry DOI: 10.7270/Q2542PQ0
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50402149
PNG
(CHEMBL2208006)
Show SMILES CCCC(=O)CCc1nc(c([nH]1)-c1nc(C)cs1)-c1ccc2ncsc2c1
Show InChI InChI=1S/C20H20N4OS2/c1-3-4-14(25)6-8-17-23-18(19(24-17)20-22-12(2)10-26-20)13-5-7-15-16(9-13)27-11-21-15/h5,7,9-11H,3-4,6,8H2,1-2H3,(H,23,24)
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Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISA

Bioorg Med Chem 20: 7128-38 (2012)


Article DOI: 10.1016/j.bmc.2012.09.066
BindingDB Entry DOI: 10.7270/Q2542PQ0
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50402171
PNG
(CHEMBL2208020)
Show SMILES CCCCOC(=O)NCc1nc(c([nH]1)-c1nc(C)cs1)-c1ccc2ncsc2c1
Show InChI InChI=1S/C20H21N5O2S2/c1-3-4-7-27-20(26)21-9-16-24-17(18(25-16)19-23-12(2)10-28-19)13-5-6-14-15(8-13)29-11-22-14/h5-6,8,10-11H,3-4,7,9H2,1-2H3,(H,21,26)(H,24,25)
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n/an/a 9.10n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISA

Bioorg Med Chem 20: 7128-38 (2012)


Article DOI: 10.1016/j.bmc.2012.09.066
BindingDB Entry DOI: 10.7270/Q2542PQ0
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50402167
PNG
(CHEMBL2208238)
Show SMILES Cc1csc(n1)-c1[nH]c(CNC(=O)OCC(C)(C)C)nc1-c1ccc2ncsc2c1
Show InChI InChI=1S/C21H23N5O2S2/c1-12-9-29-19(24-12)18-17(13-5-6-14-15(7-13)30-11-23-14)25-16(26-18)8-22-20(27)28-10-21(2,3)4/h5-7,9,11H,8,10H2,1-4H3,(H,22,27)(H,25,26)
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n/an/a 9.30n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISA

Bioorg Med Chem 20: 7128-38 (2012)


Article DOI: 10.1016/j.bmc.2012.09.066
BindingDB Entry DOI: 10.7270/Q2542PQ0
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50402170
PNG
(CHEMBL2208021)
Show SMILES CCCCCOC(=O)NCc1nc(c([nH]1)-c1nc(C)cs1)-c1ccc2ncsc2c1
Show InChI InChI=1S/C21H23N5O2S2/c1-3-4-5-8-28-21(27)22-10-17-25-18(19(26-17)20-24-13(2)11-29-20)14-6-7-15-16(9-14)30-12-23-15/h6-7,9,11-12H,3-5,8,10H2,1-2H3,(H,22,27)(H,25,26)
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n/an/a 11n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISA

Bioorg Med Chem 20: 7128-38 (2012)


Article DOI: 10.1016/j.bmc.2012.09.066
BindingDB Entry DOI: 10.7270/Q2542PQ0
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50402177
PNG
(CHEMBL2208014)
Show SMILES CCNC(=O)NCc1nc(c([nH]1)-c1nc(C)cs1)-c1ccc2ncsc2c1
Show InChI InChI=1S/C18H18N6OS2/c1-3-19-18(25)20-7-14-23-15(16(24-14)17-22-10(2)8-26-17)11-4-5-12-13(6-11)27-9-21-12/h4-6,8-9H,3,7H2,1-2H3,(H,23,24)(H2,19,20,25)
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n/an/a 11n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISA

Bioorg Med Chem 20: 7128-38 (2012)


Article DOI: 10.1016/j.bmc.2012.09.066
BindingDB Entry DOI: 10.7270/Q2542PQ0
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50402147
PNG
(CHEMBL2208008)
Show SMILES CCNC(=O)CCc1nc(c([nH]1)-c1nc(C)cs1)-c1ccc2ncsc2c1
Show InChI InChI=1S/C19H19N5OS2/c1-3-20-16(25)7-6-15-23-17(18(24-15)19-22-11(2)9-26-19)12-4-5-13-14(8-12)27-10-21-13/h4-5,8-10H,3,6-7H2,1-2H3,(H,20,25)(H,23,24)
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n/an/a 12n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISA

Bioorg Med Chem 20: 7128-38 (2012)


Article DOI: 10.1016/j.bmc.2012.09.066
BindingDB Entry DOI: 10.7270/Q2542PQ0
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50402155
PNG
(CHEMBL2207999)
Show SMILES Cc1csc(n1)-c1[nH]c(nc1-c1ccc2ncsc2c1)C1CCCCC1
Show InChI InChI=1S/C20H20N4S2/c1-12-10-25-20(22-12)18-17(14-7-8-15-16(9-14)26-11-21-15)23-19(24-18)13-5-3-2-4-6-13/h7-11,13H,2-6H2,1H3,(H,23,24)
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n/an/a 12n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISA

Bioorg Med Chem 20: 7128-38 (2012)


Article DOI: 10.1016/j.bmc.2012.09.066
BindingDB Entry DOI: 10.7270/Q2542PQ0
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50402150
PNG
(CHEMBL2208005)
Show SMILES CCCCNCc1nc(c([nH]1)-c1nc(C)cs1)-c1ccc2ncsc2c1
Show InChI InChI=1S/C19H21N5S2/c1-3-4-7-20-9-16-23-17(18(24-16)19-22-12(2)10-25-19)13-5-6-14-15(8-13)26-11-21-14/h5-6,8,10-11,20H,3-4,7,9H2,1-2H3,(H,23,24)
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n/an/a 13n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISA

Bioorg Med Chem 20: 7128-38 (2012)


Article DOI: 10.1016/j.bmc.2012.09.066
BindingDB Entry DOI: 10.7270/Q2542PQ0
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50402160
PNG
(CHEMBL2207994)
Show SMILES Cc1csc(n1)-c1[nH]c(nc1-c1ccc2ncsc2c1)C(C)(C)C
Show InChI InChI=1S/C18H18N4S2/c1-10-8-23-16(20-10)15-14(21-17(22-15)18(2,3)4)11-5-6-12-13(7-11)24-9-19-12/h5-9H,1-4H3,(H,21,22)
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n/an/a 14n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISA

Bioorg Med Chem 20: 7128-38 (2012)


Article DOI: 10.1016/j.bmc.2012.09.066
BindingDB Entry DOI: 10.7270/Q2542PQ0
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50402176
PNG
(CHEMBL2208015)
Show SMILES CCCS(=O)(=O)NCc1nc(c([nH]1)-c1nc(C)cs1)-c1ccc2ncsc2c1
Show InChI InChI=1S/C18H19N5O2S3/c1-3-6-28(24,25)20-8-15-22-16(17(23-15)18-21-11(2)9-26-18)12-4-5-13-14(7-12)27-10-19-13/h4-5,7,9-10,20H,3,6,8H2,1-2H3,(H,22,23)
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n/an/a 17n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISA

Bioorg Med Chem 20: 7128-38 (2012)


Article DOI: 10.1016/j.bmc.2012.09.066
BindingDB Entry DOI: 10.7270/Q2542PQ0
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50402165
PNG
(CHEMBL2207989)
Show SMILES Cc1csc(n1)-c1[nH]c(C)nc1-c1ccc2ncsc2c1
Show InChI InChI=1S/C15H12N4S2/c1-8-6-20-15(17-8)14-13(18-9(2)19-14)10-3-4-11-12(5-10)21-7-16-11/h3-7H,1-2H3,(H,18,19)
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n/an/a 17n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of ALK5-mediated TNFalpha-induced Smad2/3 phosphorylation in human A549 cells preincubated for 2 hrs before addition of TNFalpha after 1 h...

Bioorg Med Chem 20: 7128-38 (2012)


Article DOI: 10.1016/j.bmc.2012.09.066
BindingDB Entry DOI: 10.7270/Q2542PQ0
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50402153
PNG
(CHEMBL2208001)
Show SMILES Cc1csc(n1)-c1[nH]c(nc1-c1ccc2ncsc2c1)C1CCOCC1
Show InChI InChI=1S/C19H18N4OS2/c1-11-9-25-19(21-11)17-16(13-2-3-14-15(8-13)26-10-20-14)22-18(23-17)12-4-6-24-7-5-12/h2-3,8-10,12H,4-7H2,1H3,(H,22,23)
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n/an/a 21n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISA

Bioorg Med Chem 20: 7128-38 (2012)


Article DOI: 10.1016/j.bmc.2012.09.066
BindingDB Entry DOI: 10.7270/Q2542PQ0
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50402154
PNG
(CHEMBL2208000)
Show SMILES Cc1csc(n1)-c1[nH]c(nc1-c1ccc2ncsc2c1)C1CCC(=O)CC1
Show InChI InChI=1S/C20H18N4OS2/c1-11-9-26-20(22-11)18-17(13-4-7-15-16(8-13)27-10-21-15)23-19(24-18)12-2-5-14(25)6-3-12/h4,7-10,12H,2-3,5-6H2,1H3,(H,23,24)
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n/an/a 23n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISA

Bioorg Med Chem 20: 7128-38 (2012)


Article DOI: 10.1016/j.bmc.2012.09.066
BindingDB Entry DOI: 10.7270/Q2542PQ0
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50402179
PNG
(CHEMBL2208012)
Show SMILES CCC(=O)NCCc1nc(c([nH]1)-c1nc(C)cs1)-c1ccc2ncsc2c1
Show InChI InChI=1S/C19H19N5OS2/c1-3-16(25)20-7-6-15-23-17(18(24-15)19-22-11(2)9-26-19)12-4-5-13-14(8-12)27-10-21-13/h4-5,8-10H,3,6-7H2,1-2H3,(H,20,25)(H,23,24)
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n/an/a 25n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISA

Bioorg Med Chem 20: 7128-38 (2012)


Article DOI: 10.1016/j.bmc.2012.09.066
BindingDB Entry DOI: 10.7270/Q2542PQ0
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50402152
PNG
(CHEMBL2208003)
Show SMILES Cc1csc(n1)-c1[nH]c(CN2CCCC2=O)nc1-c1ccc2ncsc2c1
Show InChI InChI=1S/C19H17N5OS2/c1-11-9-26-19(21-11)18-17(12-4-5-13-14(7-12)27-10-20-13)22-15(23-18)8-24-6-2-3-16(24)25/h4-5,7,9-10H,2-3,6,8H2,1H3,(H,22,23)
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n/an/a 26n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISA

Bioorg Med Chem 20: 7128-38 (2012)


Article DOI: 10.1016/j.bmc.2012.09.066
BindingDB Entry DOI: 10.7270/Q2542PQ0
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50402178
PNG
(CHEMBL2208013)
Show SMILES CC(=O)NCCCc1nc(c([nH]1)-c1nc(C)cs1)-c1ccc2ncsc2c1
Show InChI InChI=1S/C19H19N5OS2/c1-11-9-26-19(22-11)18-17(13-5-6-14-15(8-13)27-10-21-14)23-16(24-18)4-3-7-20-12(2)25/h5-6,8-10H,3-4,7H2,1-2H3,(H,20,25)(H,23,24)
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n/an/a 26n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISA

Bioorg Med Chem 20: 7128-38 (2012)


Article DOI: 10.1016/j.bmc.2012.09.066
BindingDB Entry DOI: 10.7270/Q2542PQ0
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50402151
PNG
(CHEMBL2208004)
Show SMILES CCCC(=O)N(C)Cc1nc(c([nH]1)-c1nc(C)cs1)-c1ccc2ncsc2c1
Show InChI InChI=1S/C20H21N5OS2/c1-4-5-17(26)25(3)9-16-23-18(19(24-16)20-22-12(2)10-27-20)13-6-7-14-15(8-13)28-11-21-14/h6-8,10-11H,4-5,9H2,1-3H3,(H,23,24)
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n/an/a 28n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISA

Bioorg Med Chem 20: 7128-38 (2012)


Article DOI: 10.1016/j.bmc.2012.09.066
BindingDB Entry DOI: 10.7270/Q2542PQ0
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50402163
PNG
(CHEMBL2207991)
Show SMILES CCCc1nc(c([nH]1)-c1nc(C)cs1)-c1ccc2ncsc2c1
Show InChI InChI=1S/C17H16N4S2/c1-3-4-14-20-15(16(21-14)17-19-10(2)8-22-17)11-5-6-12-13(7-11)23-9-18-12/h5-9H,3-4H2,1-2H3,(H,20,21)
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n/an/a 33n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of ALK5-mediated TNFalpha-induced Smad2/3 phosphorylation in human A549 cells preincubated for 2 hrs before addition of TNFalpha after 1 h...

Bioorg Med Chem 20: 7128-38 (2012)


Article DOI: 10.1016/j.bmc.2012.09.066
BindingDB Entry DOI: 10.7270/Q2542PQ0
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50402164
PNG
(CHEMBL2207990)
Show SMILES CCc1nc(c([nH]1)-c1nc(C)cs1)-c1ccc2ncsc2c1
Show InChI InChI=1S/C16H14N4S2/c1-3-13-19-14(15(20-13)16-18-9(2)7-21-16)10-4-5-11-12(6-10)22-8-17-11/h4-8H,3H2,1-2H3,(H,19,20)
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n/an/a 35n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of ALK5-mediated TNFalpha-induced Smad2/3 phosphorylation in human A549 cells preincubated for 2 hrs before addition of TNFalpha after 1 h...

Bioorg Med Chem 20: 7128-38 (2012)


Article DOI: 10.1016/j.bmc.2012.09.066
BindingDB Entry DOI: 10.7270/Q2542PQ0
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50402175
PNG
(CHEMBL2208016)
Show SMILES CCOC(=O)NCc1nc(c([nH]1)-c1nc(C)cs1)-c1ccc2ncsc2c1
Show InChI InChI=1S/C18H17N5O2S2/c1-3-25-18(24)19-7-14-22-15(16(23-14)17-21-10(2)8-26-17)11-4-5-12-13(6-11)27-9-20-12/h4-6,8-9H,3,7H2,1-2H3,(H,19,24)(H,22,23)
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n/an/a 35n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of ALK5-mediated TNFalpha-induced Smad2/3 phosphorylation in human A549 cells preincubated for 2 hrs before addition of TNFalpha after 1 h...

Bioorg Med Chem 20: 7128-38 (2012)


Article DOI: 10.1016/j.bmc.2012.09.066
BindingDB Entry DOI: 10.7270/Q2542PQ0
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50402168
PNG
(CHEMBL2208237)
Show SMILES CC(C)COC(=O)NCc1nc(c([nH]1)-c1nc(C)cs1)-c1ccc2ncsc2c1
Show InChI InChI=1S/C20H21N5O2S2/c1-11(2)8-27-20(26)21-7-16-24-17(18(25-16)19-23-12(3)9-28-19)13-4-5-14-15(6-13)29-10-22-14/h4-6,9-11H,7-8H2,1-3H3,(H,21,26)(H,24,25)
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n/an/a 36n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of ALK5-mediated TNFalpha-induced Smad2/3 phosphorylation in human A549 cells preincubated for 2 hrs before addition of TNFalpha after 1 h...

Bioorg Med Chem 20: 7128-38 (2012)


Article DOI: 10.1016/j.bmc.2012.09.066
BindingDB Entry DOI: 10.7270/Q2542PQ0
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50402172
PNG
(CHEMBL2208019)
Show SMILES CCCOC(=O)NCc1nc(c([nH]1)-c1nc(C)cs1)-c1ccc2ncsc2c1
Show InChI InChI=1S/C19H19N5O2S2/c1-3-6-26-19(25)20-8-15-23-16(17(24-15)18-22-11(2)9-27-18)12-4-5-13-14(7-12)28-10-21-13/h4-5,7,9-10H,3,6,8H2,1-2H3,(H,20,25)(H,23,24)
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n/an/a 36n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of ALK5-mediated TNFalpha-induced Smad2/3 phosphorylation in human A549 cells preincubated for 2 hrs before addition of TNFalpha after 1 h...

Bioorg Med Chem 20: 7128-38 (2012)


Article DOI: 10.1016/j.bmc.2012.09.066
BindingDB Entry DOI: 10.7270/Q2542PQ0
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50402146
PNG
(CHEMBL2208009)
Show SMILES CNC(=O)CCCc1nc(c([nH]1)-c1nc(C)cs1)-c1ccc2ncsc2c1
Show InChI InChI=1S/C19H19N5OS2/c1-11-9-26-19(22-11)18-17(12-6-7-13-14(8-12)27-10-21-13)23-15(24-18)4-3-5-16(25)20-2/h6-10H,3-5H2,1-2H3,(H,20,25)(H,23,24)
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n/an/a 37n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISA

Bioorg Med Chem 20: 7128-38 (2012)


Article DOI: 10.1016/j.bmc.2012.09.066
BindingDB Entry DOI: 10.7270/Q2542PQ0
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50402173
PNG
(CHEMBL2208018)
Show SMILES COC(=O)NCc1nc(c([nH]1)-c1nc(C)cs1)-c1ccc2ncsc2c1
Show InChI InChI=1S/C17H15N5O2S2/c1-9-7-25-16(20-9)15-14(21-13(22-15)6-18-17(23)24-2)10-3-4-11-12(5-10)26-8-19-11/h3-5,7-8H,6H2,1-2H3,(H,18,23)(H,21,22)
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n/an/a 38n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of ALK5-mediated TNFalpha-induced Smad2/3 phosphorylation in human A549 cells preincubated for 2 hrs before addition of TNFalpha after 1 h...

Bioorg Med Chem 20: 7128-38 (2012)


Article DOI: 10.1016/j.bmc.2012.09.066
BindingDB Entry DOI: 10.7270/Q2542PQ0
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50402156
PNG
(CHEMBL2207998)
Show SMILES Cc1csc(n1)-c1[nH]c(nc1-c1ccc2ncsc2c1)C1CCCC1
Show InChI InChI=1S/C19H18N4S2/c1-11-9-24-19(21-11)17-16(22-18(23-17)12-4-2-3-5-12)13-6-7-14-15(8-13)25-10-20-14/h6-10,12H,2-5H2,1H3,(H,22,23)
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n/an/a 40n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of ALK5-mediated TNFalpha-induced Smad2/3 phosphorylation in human A549 cells preincubated for 2 hrs before addition of TNFalpha after 1 h...

Bioorg Med Chem 20: 7128-38 (2012)


Article DOI: 10.1016/j.bmc.2012.09.066
BindingDB Entry DOI: 10.7270/Q2542PQ0
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50402169
PNG
(CHEMBL2208022)
Show SMILES CC(C)OC(=O)NCc1nc(c([nH]1)-c1nc(C)cs1)-c1ccc2ncsc2c1
Show InChI InChI=1S/C19H19N5O2S2/c1-10(2)26-19(25)20-7-15-23-16(17(24-15)18-22-11(3)8-27-18)12-4-5-13-14(6-12)28-9-21-13/h4-6,8-10H,7H2,1-3H3,(H,20,25)(H,23,24)
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n/an/a 41n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of ALK5-mediated TNFalpha-induced Smad2/3 phosphorylation in human A549 cells preincubated for 2 hrs before addition of TNFalpha after 1 h...

Bioorg Med Chem 20: 7128-38 (2012)


Article DOI: 10.1016/j.bmc.2012.09.066
BindingDB Entry DOI: 10.7270/Q2542PQ0
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50402149
PNG
(CHEMBL2208006)
Show SMILES CCCC(=O)CCc1nc(c([nH]1)-c1nc(C)cs1)-c1ccc2ncsc2c1
Show InChI InChI=1S/C20H20N4OS2/c1-3-4-14(25)6-8-17-23-18(19(24-17)20-22-12(2)10-26-20)13-5-7-15-16(9-13)27-11-21-15/h5,7,9-11H,3-4,6,8H2,1-2H3,(H,23,24)
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n/an/a 42n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of ALK5-mediated TNFalpha-induced Smad2/3 phosphorylation in human A549 cells preincubated for 2 hrs before addition of TNFalpha after 1 h...

Bioorg Med Chem 20: 7128-38 (2012)


Article DOI: 10.1016/j.bmc.2012.09.066
BindingDB Entry DOI: 10.7270/Q2542PQ0
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50402161
PNG
(CHEMBL2207993)
Show SMILES CC(C)Cc1nc(c([nH]1)-c1nc(C)cs1)-c1ccc2ncsc2c1
Show InChI InChI=1S/C18H18N4S2/c1-10(2)6-15-21-16(17(22-15)18-20-11(3)8-23-18)12-4-5-13-14(7-12)24-9-19-13/h4-5,7-10H,6H2,1-3H3,(H,21,22)
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n/an/a 43n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of ALK5-mediated TNFalpha-induced Smad2/3 phosphorylation in human A549 cells preincubated for 2 hrs before addition of TNFalpha after 1 h...

Bioorg Med Chem 20: 7128-38 (2012)


Article DOI: 10.1016/j.bmc.2012.09.066
BindingDB Entry DOI: 10.7270/Q2542PQ0
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50402157
PNG
(CHEMBL2207997)
Show SMILES Cc1csc(n1)-c1[nH]c(nc1-c1ccc2ncsc2c1)C1CC1
Show InChI InChI=1S/C17H14N4S2/c1-9-7-22-17(19-9)15-14(20-16(21-15)10-2-3-10)11-4-5-12-13(6-11)23-8-18-12/h4-8,10H,2-3H2,1H3,(H,20,21)
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n/an/a 45n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of ALK5-mediated TNFalpha-induced Smad2/3 phosphorylation in human A549 cells preincubated for 2 hrs before addition of TNFalpha after 1 h...

Bioorg Med Chem 20: 7128-38 (2012)


Article DOI: 10.1016/j.bmc.2012.09.066
BindingDB Entry DOI: 10.7270/Q2542PQ0
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50402148
PNG
(CHEMBL2208007)
Show SMILES CCCCNC(=O)c1nc(c([nH]1)-c1nc(C)cs1)-c1ccc2ncsc2c1
Show InChI InChI=1S/C19H19N5OS2/c1-3-4-7-20-18(25)17-23-15(16(24-17)19-22-11(2)9-26-19)12-5-6-13-14(8-12)27-10-21-13/h5-6,8-10H,3-4,7H2,1-2H3,(H,20,25)(H,23,24)
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n/an/a 45n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISA

Bioorg Med Chem 20: 7128-38 (2012)


Article DOI: 10.1016/j.bmc.2012.09.066
BindingDB Entry DOI: 10.7270/Q2542PQ0
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50402162
PNG
(CHEMBL2207992)
Show SMILES CC(C)c1nc(c([nH]1)-c1nc(C)cs1)-c1ccc2ncsc2c1
Show InChI InChI=1S/C17H16N4S2/c1-9(2)16-20-14(15(21-16)17-19-10(3)7-22-17)11-4-5-12-13(6-11)23-8-18-12/h4-9H,1-3H3,(H,20,21)
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n/an/a 48n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of ALK5-mediated TNFalpha-induced Smad2/3 phosphorylation in human A549 cells preincubated for 2 hrs before addition of TNFalpha after 1 h...

Bioorg Med Chem 20: 7128-38 (2012)


Article DOI: 10.1016/j.bmc.2012.09.066
BindingDB Entry DOI: 10.7270/Q2542PQ0
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50402158
PNG
(CHEMBL2207996)
Show SMILES Cc1csc(n1)-c1[nH]c(nc1-c1ccc2ncsc2c1)C(F)(F)F
Show InChI InChI=1S/C15H9F3N4S2/c1-7-5-23-13(20-7)12-11(21-14(22-12)15(16,17)18)8-2-3-9-10(4-8)24-6-19-9/h2-6H,1H3,(H,21,22)
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n/an/a 49n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of ALK5-mediated TNFalpha-induced Smad2/3 phosphorylation in human A549 cells preincubated for 2 hrs before addition of TNFalpha after 1 h...

Bioorg Med Chem 20: 7128-38 (2012)


Article DOI: 10.1016/j.bmc.2012.09.066
BindingDB Entry DOI: 10.7270/Q2542PQ0
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50402160
PNG
(CHEMBL2207994)
Show SMILES Cc1csc(n1)-c1[nH]c(nc1-c1ccc2ncsc2c1)C(C)(C)C
Show InChI InChI=1S/C18H18N4S2/c1-10-8-23-16(20-10)15-14(21-17(22-15)18(2,3)4)11-5-6-12-13(7-11)24-9-19-12/h5-9H,1-4H3,(H,21,22)
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n/an/a 68n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of ALK5-mediated TNFalpha-induced Smad2/3 phosphorylation in human A549 cells preincubated for 2 hrs before addition of TNFalpha after 1 h...

Bioorg Med Chem 20: 7128-38 (2012)


Article DOI: 10.1016/j.bmc.2012.09.066
BindingDB Entry DOI: 10.7270/Q2542PQ0
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50402147
PNG
(CHEMBL2208008)
Show SMILES CCNC(=O)CCc1nc(c([nH]1)-c1nc(C)cs1)-c1ccc2ncsc2c1
Show InChI InChI=1S/C19H19N5OS2/c1-3-20-16(25)7-6-15-23-17(18(24-15)19-22-11(2)9-26-19)12-4-5-13-14(8-12)27-10-21-13/h4-5,8-10H,3,6-7H2,1-2H3,(H,20,25)(H,23,24)
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n/an/a 71n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of ALK5-mediated TNFalpha-induced Smad2/3 phosphorylation in human A549 cells preincubated for 2 hrs before addition of TNFalpha after 1 h...

Bioorg Med Chem 20: 7128-38 (2012)


Article DOI: 10.1016/j.bmc.2012.09.066
BindingDB Entry DOI: 10.7270/Q2542PQ0
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50402150
PNG
(CHEMBL2208005)
Show SMILES CCCCNCc1nc(c([nH]1)-c1nc(C)cs1)-c1ccc2ncsc2c1
Show InChI InChI=1S/C19H21N5S2/c1-3-4-7-20-9-16-23-17(18(24-16)19-22-12(2)10-25-19)13-5-6-14-15(8-13)26-11-21-14/h5-6,8,10-11,20H,3-4,7,9H2,1-2H3,(H,23,24)
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n/an/a 72n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of ALK5-mediated TNFalpha-induced Smad2/3 phosphorylation in human A549 cells preincubated for 2 hrs before addition of TNFalpha after 1 h...

Bioorg Med Chem 20: 7128-38 (2012)


Article DOI: 10.1016/j.bmc.2012.09.066
BindingDB Entry DOI: 10.7270/Q2542PQ0
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50402171
PNG
(CHEMBL2208020)
Show SMILES CCCCOC(=O)NCc1nc(c([nH]1)-c1nc(C)cs1)-c1ccc2ncsc2c1
Show InChI InChI=1S/C20H21N5O2S2/c1-3-4-7-27-20(26)21-9-16-24-17(18(25-16)19-23-12(2)10-28-19)13-5-6-14-15(8-13)29-11-22-14/h5-6,8,10-11H,3-4,7,9H2,1-2H3,(H,21,26)(H,24,25)
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n/an/a 74n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of ALK5-mediated TNFalpha-induced Smad2/3 phosphorylation in human A549 cells preincubated for 2 hrs before addition of TNFalpha after 1 h...

Bioorg Med Chem 20: 7128-38 (2012)


Article DOI: 10.1016/j.bmc.2012.09.066
BindingDB Entry DOI: 10.7270/Q2542PQ0
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50402155
PNG
(CHEMBL2207999)
Show SMILES Cc1csc(n1)-c1[nH]c(nc1-c1ccc2ncsc2c1)C1CCCCC1
Show InChI InChI=1S/C20H20N4S2/c1-12-10-25-20(22-12)18-17(14-7-8-15-16(9-14)26-11-21-15)23-19(24-18)13-5-3-2-4-6-13/h7-11,13H,2-6H2,1H3,(H,23,24)
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n/an/a 75n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of ALK5-mediated TNFalpha-induced Smad2/3 phosphorylation in human A549 cells preincubated for 2 hrs before addition of TNFalpha after 1 h...

Bioorg Med Chem 20: 7128-38 (2012)


Article DOI: 10.1016/j.bmc.2012.09.066
BindingDB Entry DOI: 10.7270/Q2542PQ0
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50402167
PNG
(CHEMBL2208238)
Show SMILES Cc1csc(n1)-c1[nH]c(CNC(=O)OCC(C)(C)C)nc1-c1ccc2ncsc2c1
Show InChI InChI=1S/C21H23N5O2S2/c1-12-9-29-19(24-12)18-17(13-5-6-14-15(7-13)30-11-23-14)25-16(26-18)8-22-20(27)28-10-21(2,3)4/h5-7,9,11H,8,10H2,1-4H3,(H,22,27)(H,25,26)
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n/an/a 79n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of ALK5-mediated TNFalpha-induced Smad2/3 phosphorylation in human A549 cells preincubated for 2 hrs before addition of TNFalpha after 1 h...

Bioorg Med Chem 20: 7128-38 (2012)


Article DOI: 10.1016/j.bmc.2012.09.066
BindingDB Entry DOI: 10.7270/Q2542PQ0
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50402154
PNG
(CHEMBL2208000)
Show SMILES Cc1csc(n1)-c1[nH]c(nc1-c1ccc2ncsc2c1)C1CCC(=O)CC1
Show InChI InChI=1S/C20H18N4OS2/c1-11-9-26-20(22-11)18-17(13-4-7-15-16(8-13)27-10-21-15)23-19(24-18)12-2-5-14(25)6-3-12/h4,7-10,12H,2-3,5-6H2,1H3,(H,23,24)
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n/an/a 89n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of ALK5-mediated TNFalpha-induced Smad2/3 phosphorylation in human A549 cells preincubated for 2 hrs before addition of TNFalpha after 1 h...

Bioorg Med Chem 20: 7128-38 (2012)


Article DOI: 10.1016/j.bmc.2012.09.066
BindingDB Entry DOI: 10.7270/Q2542PQ0
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50402174
PNG
(CHEMBL2208017)
Show SMILES Cc1csc(n1)-c1[nH]c(CN2CCOC2=O)nc1-c1ccc2ncsc2c1
Show InChI InChI=1S/C18H15N5O2S2/c1-10-8-26-17(20-10)16-15(11-2-3-12-13(6-11)27-9-19-12)21-14(22-16)7-23-4-5-25-18(23)24/h2-3,6,8-9H,4-5,7H2,1H3,(H,21,22)
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n/an/a 92n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of ALK5-mediated TNFalpha-induced Smad2/3 phosphorylation in human A549 cells preincubated for 2 hrs before addition of TNFalpha after 1 h...

Bioorg Med Chem 20: 7128-38 (2012)


Article DOI: 10.1016/j.bmc.2012.09.066
BindingDB Entry DOI: 10.7270/Q2542PQ0
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50402144
PNG
(CHEMBL2208011)
Show SMILES CCNC(=O)OCc1nc(c([nH]1)-c1nc(C)cs1)-c1ccc2ncsc2c1
Show InChI InChI=1S/C18H17N5O2S2/c1-3-19-18(24)25-7-14-22-15(16(23-14)17-21-10(2)8-26-17)11-4-5-12-13(6-11)27-9-20-12/h4-6,8-9H,3,7H2,1-2H3,(H,19,24)(H,22,23)
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n/an/a 93n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of ALK5-mediated TNFalpha-induced Smad2/3 phosphorylation in human A549 cells preincubated for 2 hrs before addition of TNFalpha after 1 h...

Bioorg Med Chem 20: 7128-38 (2012)


Article DOI: 10.1016/j.bmc.2012.09.066
BindingDB Entry DOI: 10.7270/Q2542PQ0
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50402153
PNG
(CHEMBL2208001)
Show SMILES Cc1csc(n1)-c1[nH]c(nc1-c1ccc2ncsc2c1)C1CCOCC1
Show InChI InChI=1S/C19H18N4OS2/c1-11-9-25-19(21-11)17-16(13-2-3-14-15(8-13)26-10-20-14)22-18(23-17)12-4-6-24-7-5-12/h2-3,8-10,12H,4-7H2,1H3,(H,22,23)
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n/an/a 99n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of ALK5-mediated TNFalpha-induced Smad2/3 phosphorylation in human A549 cells preincubated for 2 hrs before addition of TNFalpha after 1 h...

Bioorg Med Chem 20: 7128-38 (2012)


Article DOI: 10.1016/j.bmc.2012.09.066
BindingDB Entry DOI: 10.7270/Q2542PQ0
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50402151
PNG
(CHEMBL2208004)
Show SMILES CCCC(=O)N(C)Cc1nc(c([nH]1)-c1nc(C)cs1)-c1ccc2ncsc2c1
Show InChI InChI=1S/C20H21N5OS2/c1-4-5-17(26)25(3)9-16-23-18(19(24-16)20-22-12(2)10-27-20)13-6-7-14-15(8-13)28-11-21-14/h6-8,10-11H,4-5,9H2,1-3H3,(H,23,24)
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n/an/a 110n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of ALK5-mediated TNFalpha-induced Smad2/3 phosphorylation in human A549 cells preincubated for 2 hrs before addition of TNFalpha after 1 h...

Bioorg Med Chem 20: 7128-38 (2012)


Article DOI: 10.1016/j.bmc.2012.09.066
BindingDB Entry DOI: 10.7270/Q2542PQ0
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50402159
PNG
(CHEMBL2207995)
Show SMILES CCCCCCc1nc(c([nH]1)-c1nc(C)cs1)-c1ccc2ncsc2c1
Show InChI InChI=1S/C20H22N4S2/c1-3-4-5-6-7-17-23-18(19(24-17)20-22-13(2)11-25-20)14-8-9-15-16(10-14)26-12-21-15/h8-12H,3-7H2,1-2H3,(H,23,24)
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n/an/a 120n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of ALK5-mediated TNFalpha-induced Smad2/3 phosphorylation in human A549 cells preincubated for 2 hrs before addition of TNFalpha after 1 h...

Bioorg Med Chem 20: 7128-38 (2012)


Article DOI: 10.1016/j.bmc.2012.09.066
BindingDB Entry DOI: 10.7270/Q2542PQ0
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50402152
PNG
(CHEMBL2208003)
Show SMILES Cc1csc(n1)-c1[nH]c(CN2CCCC2=O)nc1-c1ccc2ncsc2c1
Show InChI InChI=1S/C19H17N5OS2/c1-11-9-26-19(21-11)18-17(12-4-5-13-14(7-12)27-10-20-13)22-15(23-18)8-24-6-2-3-16(24)25/h4-5,7,9-10H,2-3,6,8H2,1H3,(H,22,23)
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n/an/a 130n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of ALK5-mediated TNFalpha-induced Smad2/3 phosphorylation in human A549 cells preincubated for 2 hrs before addition of TNFalpha after 1 h...

Bioorg Med Chem 20: 7128-38 (2012)


Article DOI: 10.1016/j.bmc.2012.09.066
BindingDB Entry DOI: 10.7270/Q2542PQ0
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50402179
PNG
(CHEMBL2208012)
Show SMILES CCC(=O)NCCc1nc(c([nH]1)-c1nc(C)cs1)-c1ccc2ncsc2c1
Show InChI InChI=1S/C19H19N5OS2/c1-3-16(25)20-7-6-15-23-17(18(24-15)19-22-11(2)9-26-19)12-4-5-13-14(8-12)27-10-21-13/h4-5,8-10H,3,6-7H2,1-2H3,(H,20,25)(H,23,24)
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n/an/a 130n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of ALK5-mediated TNFalpha-induced Smad2/3 phosphorylation in human A549 cells preincubated for 2 hrs before addition of TNFalpha after 1 h...

Bioorg Med Chem 20: 7128-38 (2012)


Article DOI: 10.1016/j.bmc.2012.09.066
BindingDB Entry DOI: 10.7270/Q2542PQ0
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50402177
PNG
(CHEMBL2208014)
Show SMILES CCNC(=O)NCc1nc(c([nH]1)-c1nc(C)cs1)-c1ccc2ncsc2c1
Show InChI InChI=1S/C18H18N6OS2/c1-3-19-18(25)20-7-14-23-15(16(24-14)17-22-10(2)8-26-17)11-4-5-12-13(6-11)27-9-21-12/h4-6,8-9H,3,7H2,1-2H3,(H,23,24)(H2,19,20,25)
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n/an/a 130n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of ALK5-mediated TNFalpha-induced Smad2/3 phosphorylation in human A549 cells preincubated for 2 hrs before addition of TNFalpha after 1 h...

Bioorg Med Chem 20: 7128-38 (2012)


Article DOI: 10.1016/j.bmc.2012.09.066
BindingDB Entry DOI: 10.7270/Q2542PQ0
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50402170
PNG
(CHEMBL2208021)
Show SMILES CCCCCOC(=O)NCc1nc(c([nH]1)-c1nc(C)cs1)-c1ccc2ncsc2c1
Show InChI InChI=1S/C21H23N5O2S2/c1-3-4-5-8-28-21(27)22-10-17-25-18(19(26-17)20-24-13(2)11-29-20)14-6-7-15-16(9-14)30-12-23-15/h6-7,9,11-12H,3-5,8,10H2,1-2H3,(H,22,27)(H,25,26)
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n/an/a 140n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of ALK5-mediated TNFalpha-induced Smad2/3 phosphorylation in human A549 cells preincubated for 2 hrs before addition of TNFalpha after 1 h...

Bioorg Med Chem 20: 7128-38 (2012)


Article DOI: 10.1016/j.bmc.2012.09.066
BindingDB Entry DOI: 10.7270/Q2542PQ0
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50402178
PNG
(CHEMBL2208013)
Show SMILES CC(=O)NCCCc1nc(c([nH]1)-c1nc(C)cs1)-c1ccc2ncsc2c1
Show InChI InChI=1S/C19H19N5OS2/c1-11-9-26-19(22-11)18-17(13-5-6-14-15(8-13)27-10-21-14)23-16(24-18)4-3-7-20-12(2)25/h5-6,8-10H,3-4,7H2,1-2H3,(H,20,25)(H,23,24)
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n/an/a 150n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of ALK5-mediated TNFalpha-induced Smad2/3 phosphorylation in human A549 cells preincubated for 2 hrs before addition of TNFalpha after 1 h...

Bioorg Med Chem 20: 7128-38 (2012)


Article DOI: 10.1016/j.bmc.2012.09.066
BindingDB Entry DOI: 10.7270/Q2542PQ0
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50402176
PNG
(CHEMBL2208015)
Show SMILES CCCS(=O)(=O)NCc1nc(c([nH]1)-c1nc(C)cs1)-c1ccc2ncsc2c1
Show InChI InChI=1S/C18H19N5O2S3/c1-3-6-28(24,25)20-8-15-22-16(17(23-15)18-21-11(2)9-26-18)12-4-5-13-14(7-12)27-10-19-13/h4-5,7,9-10,20H,3,6,8H2,1-2H3,(H,22,23)
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n/an/a 150n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of ALK5-mediated TNFalpha-induced Smad2/3 phosphorylation in human A549 cells preincubated for 2 hrs before addition of TNFalpha after 1 h...

Bioorg Med Chem 20: 7128-38 (2012)


Article DOI: 10.1016/j.bmc.2012.09.066
BindingDB Entry DOI: 10.7270/Q2542PQ0
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50402145
PNG
(CHEMBL2208010)
Show SMILES Cc1csc(n1)-c1[nH]c(CCCCC(N)=O)nc1-c1ccc2ncsc2c1
Show InChI InChI=1S/C19H19N5OS2/c1-11-9-26-19(22-11)18-17(12-6-7-13-14(8-12)27-10-21-13)23-16(24-18)5-3-2-4-15(20)25/h6-10H,2-5H2,1H3,(H2,20,25)(H,23,24)
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n/an/a 190n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of ALK5-mediated TNFalpha-induced Smad2/3 phosphorylation in human A549 cells preincubated for 2 hrs before addition of TNFalpha after 1 h...

Bioorg Med Chem 20: 7128-38 (2012)


Article DOI: 10.1016/j.bmc.2012.09.066
BindingDB Entry DOI: 10.7270/Q2542PQ0
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50402146
PNG
(CHEMBL2208009)
Show SMILES CNC(=O)CCCc1nc(c([nH]1)-c1nc(C)cs1)-c1ccc2ncsc2c1
Show InChI InChI=1S/C19H19N5OS2/c1-11-9-26-19(22-11)18-17(12-6-7-13-14(8-12)27-10-21-13)23-15(24-18)4-3-5-16(25)20-2/h6-10H,3-5H2,1-2H3,(H,20,25)(H,23,24)
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n/an/a 230n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of ALK5-mediated TNFalpha-induced Smad2/3 phosphorylation in human A549 cells preincubated for 2 hrs before addition of TNFalpha after 1 h...

Bioorg Med Chem 20: 7128-38 (2012)


Article DOI: 10.1016/j.bmc.2012.09.066
BindingDB Entry DOI: 10.7270/Q2542PQ0
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50402180
PNG
(CHEMBL2208002)
Show SMILES Cc1csc(n1)-c1[nH]c(nc1-c1ccc2ncsc2c1)C1CCNCC1
Show InChI InChI=1S/C19H19N5S2/c1-11-9-25-19(22-11)17-16(13-2-3-14-15(8-13)26-10-21-14)23-18(24-17)12-4-6-20-7-5-12/h2-3,8-10,12,20H,4-7H2,1H3,(H,23,24)
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n/an/a 240n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISA

Bioorg Med Chem 20: 7128-38 (2012)


Article DOI: 10.1016/j.bmc.2012.09.066
BindingDB Entry DOI: 10.7270/Q2542PQ0
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))		BDBM50402148
PNG
(CHEMBL2208007)
Show SMILES CCCCNC(=O)c1nc(c([nH]1)-c1nc(C)cs1)-c1ccc2ncsc2c1
Show InChI InChI=1S/C19H19N5OS2/c1-3-4-7-20-18(25)17-23-15(16(24-17)19-22-11(2)9-26-19)12-5-6-13-14(8-12)27-10-21-13/h5-6,8-10H,3-4,7H2,1-2H3,(H,20,25)(H,23,24)
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n/an/a 420n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of ALK5-mediated TNFalpha-induced Smad2/3 phosphorylation in human A549 cells preincubated for 2 hrs before addition of TNFalpha after 1 h...

Bioorg Med Chem 20: 7128-38 (2012)


Article DOI: 10.1016/j.bmc.2012.09.066
BindingDB Entry DOI: 10.7270/Q2542PQ0
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50402168
PNG
(CHEMBL2208237)
Show SMILES CC(C)COC(=O)NCc1nc(c([nH]1)-c1nc(C)cs1)-c1ccc2ncsc2c1
Show InChI InChI=1S/C20H21N5O2S2/c1-11(2)8-27-20(26)21-7-16-24-17(18(25-16)19-23-12(3)9-28-19)13-4-5-14-15(6-13)29-10-22-14/h4-6,9-11H,7-8H2,1-3H3,(H,21,26)(H,24,25)
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n/an/a 1.08E+3n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of KDR

Bioorg Med Chem 20: 7128-38 (2012)


Article DOI: 10.1016/j.bmc.2012.09.066
BindingDB Entry DOI: 10.7270/Q2542PQ0
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%