BindingDB logo
myBDB logout

PubMed code 23214471

Compile data set for download or QSAR
Found 56 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cytochrome P450 2C9


(Homo sapiens (Human))
BDBM50400413
PNG
(CHEMBL2177777)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc2N(CCc12)c1ccc(cc1F)S(C)(=O)=O
Show InChI InChI=1S/C22H27FN4O5S/c1-14(2)31-22(28)26-9-6-15(7-10-26)32-21-17-8-11-27(20(17)24-13-25-21)19-5-4-16(12-18(19)23)33(3,29)30/h4-5,12-15H,6-11H2,1-3H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
MCE
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.00E+3n/an/an/an/an/an/a



GlaxoSmithKline Research& Development

Curated by ChEMBL


Assay Description
Inhibition of CYP2C9


J Med Chem 55: 10972-94 (2012)


Article DOI: 10.1021/jm301404a
BindingDB Entry DOI: 10.7270/Q2RJ4KMK
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))
BDBM50400410
PNG
(CHEMBL2177780)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1cccc2N(CCc12)c1ccc(cc1F)S(C)(=O)=O
Show InChI InChI=1S/C24H29FN2O5S/c1-16(2)31-24(28)26-12-9-17(10-13-26)32-23-6-4-5-21-19(23)11-14-27(21)22-8-7-18(15-20(22)25)33(3,29)30/h4-8,15-17H,9-14H2,1-3H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 1.00E+3n/an/an/an/a



GlaxoSmithKline Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells co-expressing 6CRE-luciferase gene after 5 hrs by luciferase reporter gene assay


J Med Chem 55: 10972-94 (2012)


Article DOI: 10.1021/jm301404a
BindingDB Entry DOI: 10.7270/Q2RJ4KMK
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))
BDBM50400395
PNG
(CHEMBL2177761)
Show SMILES CCSC(=O)N1CCC(CC1)Oc1ncnc2N(CCc12)c1ccc(cc1F)S(C)(=O)=O
Show InChI InChI=1S/C21H25FN4O4S2/c1-3-31-21(27)25-9-6-14(7-10-25)30-20-16-8-11-26(19(16)23-13-24-20)18-5-4-15(12-17(18)22)32(2,28)29/h4-5,12-14H,3,6-11H2,1-2H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 31.6n/an/an/an/a



GlaxoSmithKline Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells co-expressing 6CRE-luciferase gene after 5 hrs by luciferase reporter gene assay


J Med Chem 55: 10972-94 (2012)


Article DOI: 10.1021/jm301404a
BindingDB Entry DOI: 10.7270/Q2RJ4KMK
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))
BDBM50400396
PNG
(CHEMBL2177760)
Show SMILES CSC(=O)N1CCC(CC1)Oc1ncnc2N(CCc12)c1ccc(cc1F)S(C)(=O)=O
Show InChI InChI=1S/C20H23FN4O4S2/c1-30-20(26)24-8-5-13(6-9-24)29-19-15-7-10-25(18(15)22-12-23-19)17-4-3-14(11-16(17)21)31(2,27)28/h3-4,11-13H,5-10H2,1-2H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 251n/an/an/an/a



GlaxoSmithKline Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells co-expressing 6CRE-luciferase gene after 5 hrs by luciferase reporter gene assay


J Med Chem 55: 10972-94 (2012)


Article DOI: 10.1021/jm301404a
BindingDB Entry DOI: 10.7270/Q2RJ4KMK
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))
BDBM50400405
PNG
(CHEMBL2177785)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)Oc1ncnc2N(CCc12)c1ccc(cc1F)S(C)(=O)=O
Show InChI InChI=1S/C23H29FN4O5S/c1-23(2,3)33-22(29)27-10-7-15(8-11-27)32-21-17-9-12-28(20(17)25-14-26-21)19-6-5-16(13-18(19)24)34(4,30)31/h5-6,13-15H,7-12H2,1-4H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 19.9n/an/an/an/a



GlaxoSmithKline Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells co-expressing 6CRE-luciferase gene after 5 hrs by luciferase reporter gene assay


J Med Chem 55: 10972-94 (2012)


Article DOI: 10.1021/jm301404a
BindingDB Entry DOI: 10.7270/Q2RJ4KMK
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))
BDBM50400367
PNG
(CHEMBL2181688)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc2N(CCc12)c1ccc(cc1)S(=O)N(C)C
Show InChI InChI=1S/C23H31N5O4S/c1-16(2)31-23(29)27-12-9-18(10-13-27)32-22-20-11-14-28(21(20)24-15-25-22)17-5-7-19(8-6-17)33(30)26(3)4/h5-8,15-16,18H,9-14H2,1-4H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 501n/an/an/an/a



GlaxoSmithKline Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells co-expressing 6CRE-luciferase gene after 5 hrs by luciferase reporter gene assay


J Med Chem 55: 10972-94 (2012)


Article DOI: 10.1021/jm301404a
BindingDB Entry DOI: 10.7270/Q2RJ4KMK
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))
BDBM50400369
PNG
(CHEMBL2181686)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc2N(CCc12)c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C22H24FN5O3/c1-14(2)30-22(29)27-8-5-17(6-9-27)31-21-18-7-10-28(20(18)25-13-26-21)16-4-3-15(12-24)19(23)11-16/h3-4,11,13-14,17H,5-10H2,1-2H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 398n/an/an/an/a



GlaxoSmithKline Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells co-expressing 6CRE-luciferase gene after 5 hrs by luciferase reporter gene assay


J Med Chem 55: 10972-94 (2012)


Article DOI: 10.1021/jm301404a
BindingDB Entry DOI: 10.7270/Q2RJ4KMK
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))
BDBM50400375
PNG
(CHEMBL2181680)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc2N(C(C)Cc12)c1ccc(cc1F)S(C)(=O)=O
Show InChI InChI=1S/C23H29FN4O5S/c1-14(2)32-23(29)27-9-7-16(8-10-27)33-22-18-11-15(3)28(21(18)25-13-26-22)20-6-5-17(12-19(20)24)34(4,30)31/h5-6,12-16H,7-11H2,1-4H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a>1.00E+4n/an/an/an/a



GlaxoSmithKline Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells co-expressing 6CRE-luciferase gene after 5 hrs by luciferase reporter gene assay


J Med Chem 55: 10972-94 (2012)


Article DOI: 10.1021/jm301404a
BindingDB Entry DOI: 10.7270/Q2RJ4KMK
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))
BDBM50400377
PNG
(CHEMBL2181678)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Sc1ncnc2N(CCc12)c1ccc(cc1F)S(C)(=O)=O
Show InChI InChI=1S/C22H27FN4O4S2/c1-14(2)31-22(28)26-9-6-15(7-10-26)32-21-17-8-11-27(20(17)24-13-25-21)19-5-4-16(12-18(19)23)33(3,29)30/h4-5,12-15H,6-11H2,1-3H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 79.4n/an/an/an/a



GlaxoSmithKline Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells co-expressing 6CRE-luciferase gene after 5 hrs by luciferase reporter gene assay


J Med Chem 55: 10972-94 (2012)


Article DOI: 10.1021/jm301404a
BindingDB Entry DOI: 10.7270/Q2RJ4KMK
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))
BDBM50400378
PNG
(CHEMBL2181677)
Show SMILES CC(C)OC(=O)N1CCC(CC1)N(C)c1ncnc2N(CCc12)c1ccc(cc1F)S(C)(=O)=O
Show InChI InChI=1S/C23H30FN5O4S/c1-15(2)33-23(30)28-10-7-16(8-11-28)27(3)21-18-9-12-29(22(18)26-14-25-21)20-6-5-17(13-19(20)24)34(4,31)32/h5-6,13-16H,7-12H2,1-4H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 631n/an/an/an/a



GlaxoSmithKline Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells co-expressing 6CRE-luciferase gene after 5 hrs by luciferase reporter gene assay


J Med Chem 55: 10972-94 (2012)


Article DOI: 10.1021/jm301404a
BindingDB Entry DOI: 10.7270/Q2RJ4KMK
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))
BDBM50400379
PNG
(CHEMBL2181676)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Nc1ncnc2N(CCc12)c1ccc(cc1F)S(C)(=O)=O
Show InChI InChI=1S/C22H28FN5O4S/c1-14(2)32-22(29)27-9-6-15(7-10-27)26-20-17-8-11-28(21(17)25-13-24-20)19-5-4-16(12-18(19)23)33(3,30)31/h4-5,12-15H,6-11H2,1-3H3,(H,24,25,26)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 2.00E+3n/an/an/an/a



GlaxoSmithKline Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells co-expressing 6CRE-luciferase gene after 5 hrs by luciferase reporter gene assay


J Med Chem 55: 10972-94 (2012)


Article DOI: 10.1021/jm301404a
BindingDB Entry DOI: 10.7270/Q2RJ4KMK
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))
BDBM50400382
PNG
(CHEMBL2177774)
Show SMILES CC(C)c1noc(n1)N1CCC(CC1)Oc1nc(C)nc2N(CCc12)c1ccc(cc1F)S(C)(=O)=O
Show InChI InChI=1S/C24H29FN6O4S/c1-14(2)21-28-24(35-29-21)30-10-7-16(8-11-30)34-23-18-9-12-31(22(18)26-15(3)27-23)20-6-5-17(13-19(20)25)36(4,32)33/h5-6,13-14,16H,7-12H2,1-4H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 251n/an/an/an/a



GlaxoSmithKline Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells co-expressing 6CRE-luciferase gene after 5 hrs by luciferase reporter gene assay


J Med Chem 55: 10972-94 (2012)


Article DOI: 10.1021/jm301404a
BindingDB Entry DOI: 10.7270/Q2RJ4KMK
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))
BDBM50400383
PNG
(CHEMBL2177773)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1nc(C)nc2N(CCc12)c1ccc(cc1F)S(C)(=O)=O
Show InChI InChI=1S/C23H29FN4O5S/c1-14(2)32-23(29)27-10-7-16(8-11-27)33-22-18-9-12-28(21(18)25-15(3)26-22)20-6-5-17(13-19(20)24)34(4,30)31/h5-6,13-14,16H,7-12H2,1-4H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 100n/an/an/an/a



GlaxoSmithKline Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells co-expressing 6CRE-luciferase gene after 5 hrs by luciferase reporter gene assay


J Med Chem 55: 10972-94 (2012)


Article DOI: 10.1021/jm301404a
BindingDB Entry DOI: 10.7270/Q2RJ4KMK
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))
BDBM50400389
PNG
(CHEMBL2177767)
Show SMILES CN(C)C(=O)CN1CCC(CC1)Oc1ncnc2N(CCc12)c1ccc(cc1F)S(C)(=O)=O
Show InChI InChI=1S/C22H28FN5O4S/c1-26(2)20(29)13-27-9-6-15(7-10-27)32-22-17-8-11-28(21(17)24-14-25-22)19-5-4-16(12-18(19)23)33(3,30)31/h4-5,12,14-15H,6-11,13H2,1-3H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a>1.00E+4n/an/an/an/a



GlaxoSmithKline Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells co-expressing 6CRE-luciferase gene after 5 hrs by luciferase reporter gene assay


J Med Chem 55: 10972-94 (2012)


Article DOI: 10.1021/jm301404a
BindingDB Entry DOI: 10.7270/Q2RJ4KMK
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))
BDBM50400394
PNG
(CHEMBL2177762)
Show SMILES CC(C)SC(=O)N1CCC(CC1)Oc1ncnc2N(CCc12)c1ccc(cc1F)S(C)(=O)=O
Show InChI InChI=1S/C22H27FN4O4S2/c1-14(2)32-22(28)26-9-6-15(7-10-26)31-21-17-8-11-27(20(17)24-13-25-21)19-5-4-16(12-18(19)23)33(3,29)30/h4-5,12-15H,6-11H2,1-3H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 10n/an/an/an/a



GlaxoSmithKline Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells co-expressing 6CRE-luciferase gene after 5 hrs by luciferase reporter gene assay


J Med Chem 55: 10972-94 (2012)


Article DOI: 10.1021/jm301404a
BindingDB Entry DOI: 10.7270/Q2RJ4KMK
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))
BDBM50400364
PNG
(CHEMBL2181691)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc2N(CCc12)c1ccc(cc1C)S(C)(=O)=O
Show InChI InChI=1S/C23H30N4O5S/c1-15(2)31-23(28)26-10-7-17(8-11-26)32-22-19-9-12-27(21(19)24-14-25-22)20-6-5-18(13-16(20)3)33(4,29)30/h5-6,13-15,17H,7-12H2,1-4H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 100n/an/an/an/a



GlaxoSmithKline Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells co-expressing 6CRE-luciferase gene after 5 hrs by luciferase reporter gene assay


J Med Chem 55: 10972-94 (2012)


Article DOI: 10.1021/jm301404a
BindingDB Entry DOI: 10.7270/Q2RJ4KMK
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))
BDBM50400381
PNG
(CHEMBL2177775)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1nc(N)nc2N(CCc12)c1ccc(cc1F)S(C)(=O)=O
Show InChI InChI=1S/C22H28FN5O5S/c1-13(2)32-22(29)27-9-6-14(7-10-27)33-20-16-8-11-28(19(16)25-21(24)26-20)18-5-4-15(12-17(18)23)34(3,30)31/h4-5,12-14H,6-11H2,1-3H3,(H2,24,25,26)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 794n/an/an/an/a



GlaxoSmithKline Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells co-expressing 6CRE-luciferase gene after 5 hrs by luciferase reporter gene assay


J Med Chem 55: 10972-94 (2012)


Article DOI: 10.1021/jm301404a
BindingDB Entry DOI: 10.7270/Q2RJ4KMK
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))
BDBM50400397
PNG
(CHEMBL2177759)
Show SMILES COCCOC(=O)N1CCC(CC1)Oc1ncnc2N(CCc12)c1ccc(cc1F)S(C)(=O)=O
Show InChI InChI=1S/C22H27FN4O6S/c1-31-11-12-32-22(28)26-8-5-15(6-9-26)33-21-17-7-10-27(20(17)24-14-25-21)19-4-3-16(13-18(19)23)34(2,29)30/h3-4,13-15H,5-12H2,1-2H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 316n/an/an/an/a



GlaxoSmithKline Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells co-expressing 6CRE-luciferase gene after 5 hrs by luciferase reporter gene assay


J Med Chem 55: 10972-94 (2012)


Article DOI: 10.1021/jm301404a
BindingDB Entry DOI: 10.7270/Q2RJ4KMK
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))
BDBM50400399
PNG
(CHEMBL2181695)
Show SMILES CC(C)(C)COC(=O)N1CCC(CC1)Oc1ncnc2N(CCc12)c1ccc(cc1F)S(C)(=O)=O
Show InChI InChI=1S/C24H31FN4O5S/c1-24(2,3)14-33-23(30)28-10-7-16(8-11-28)34-22-18-9-12-29(21(18)26-15-27-22)20-6-5-17(13-19(20)25)35(4,31)32/h5-6,13,15-16H,7-12,14H2,1-4H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 39.8n/an/an/an/a



GlaxoSmithKline Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells co-expressing 6CRE-luciferase gene after 5 hrs by luciferase reporter gene assay


J Med Chem 55: 10972-94 (2012)


Article DOI: 10.1021/jm301404a
BindingDB Entry DOI: 10.7270/Q2RJ4KMK
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))
BDBM50400400
PNG
(CHEMBL2181694)
Show SMILES CC(C)COC(=O)N1CCC(CC1)Oc1ncnc2N(CCc12)c1ccc(cc1F)S(C)(=O)=O
Show InChI InChI=1S/C23H29FN4O5S/c1-15(2)13-32-23(29)27-9-6-16(7-10-27)33-22-18-8-11-28(21(18)25-14-26-22)20-5-4-17(12-19(20)24)34(3,30)31/h4-5,12,14-16H,6-11,13H2,1-3H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 25.1n/an/an/an/a



GlaxoSmithKline Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells co-expressing 6CRE-luciferase gene after 5 hrs by luciferase reporter gene assay


J Med Chem 55: 10972-94 (2012)


Article DOI: 10.1021/jm301404a
BindingDB Entry DOI: 10.7270/Q2RJ4KMK
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))
BDBM50400409
PNG
(CHEMBL2177781)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc2N(CCc12)c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C22H28N4O5S/c1-15(2)30-22(27)25-11-8-17(9-12-25)31-21-19-10-13-26(20(19)23-14-24-21)16-4-6-18(7-5-16)32(3,28)29/h4-7,14-15,17H,8-13H2,1-3H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 126n/an/an/an/a



GlaxoSmithKline Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells co-expressing 6CRE-luciferase gene after 5 hrs by luciferase reporter gene assay


J Med Chem 55: 10972-94 (2012)


Article DOI: 10.1021/jm301404a
BindingDB Entry DOI: 10.7270/Q2RJ4KMK
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))
BDBM50400365
PNG
(CHEMBL2181690)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc2N(CCc12)c1ccc(c(F)c1)S(C)=O
Show InChI InChI=1S/C22H27FN4O4S/c1-14(2)30-22(28)26-9-6-16(7-10-26)31-21-17-8-11-27(20(17)24-13-25-21)15-4-5-19(32(3)29)18(23)12-15/h4-5,12-14,16H,6-11H2,1-3H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 50.1n/an/an/an/a



GlaxoSmithKline Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells co-expressing 6CRE-luciferase gene after 5 hrs by luciferase reporter gene assay


J Med Chem 55: 10972-94 (2012)


Article DOI: 10.1021/jm301404a
BindingDB Entry DOI: 10.7270/Q2RJ4KMK
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))
BDBM50400368
PNG
(CHEMBL2181687)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc2N(CCc12)c1ccc(c(F)c1)S(C)(=O)=O
Show InChI InChI=1S/C22H27FN4O5S/c1-14(2)31-22(28)26-9-6-16(7-10-26)32-21-17-8-11-27(20(17)24-13-25-21)15-4-5-19(18(23)12-15)33(3,29)30/h4-5,12-14,16H,6-11H2,1-3H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 158n/an/an/an/a



GlaxoSmithKline Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells co-expressing 6CRE-luciferase gene after 5 hrs by luciferase reporter gene assay


J Med Chem 55: 10972-94 (2012)


Article DOI: 10.1021/jm301404a
BindingDB Entry DOI: 10.7270/Q2RJ4KMK
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))
BDBM50400371
PNG
(CHEMBL2181684)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc2N(CCc12)c1ccc(F)cn1
Show InChI InChI=1S/C20H24FN5O3/c1-13(2)28-20(27)25-8-5-15(6-9-25)29-19-16-7-10-26(18(16)23-12-24-19)17-4-3-14(21)11-22-17/h3-4,11-13,15H,5-10H2,1-2H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a>1.00E+4n/an/an/an/a



GlaxoSmithKline Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells co-expressing 6CRE-luciferase gene after 5 hrs by luciferase reporter gene assay


J Med Chem 55: 10972-94 (2012)


Article DOI: 10.1021/jm301404a
BindingDB Entry DOI: 10.7270/Q2RJ4KMK
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))
BDBM50400372
PNG
(CHEMBL2181683)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc2N(CCc12)c1ccc(cn1)C#N
Show InChI InChI=1S/C21H24N6O3/c1-14(2)29-21(28)26-8-5-16(6-9-26)30-20-17-7-10-27(19(17)24-13-25-20)18-4-3-15(11-22)12-23-18/h3-4,12-14,16H,5-10H2,1-2H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 794n/an/an/an/a



GlaxoSmithKline Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells co-expressing 6CRE-luciferase gene after 5 hrs by luciferase reporter gene assay


J Med Chem 55: 10972-94 (2012)


Article DOI: 10.1021/jm301404a
BindingDB Entry DOI: 10.7270/Q2RJ4KMK
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))
BDBM50400391
PNG
(CHEMBL2177765)
Show SMILES CC(C)S(=O)(=O)N1CCC(CC1)Oc1ncnc2N(CCc12)c1ccc(cc1F)S(C)(=O)=O
Show InChI InChI=1S/C21H27FN4O5S2/c1-14(2)33(29,30)25-9-6-15(7-10-25)31-21-17-8-11-26(20(17)23-13-24-21)19-5-4-16(12-18(19)22)32(3,27)28/h4-5,12-15H,6-11H2,1-3H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 1.26E+3n/an/an/an/a



GlaxoSmithKline Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells co-expressing 6CRE-luciferase gene after 5 hrs by luciferase reporter gene assay


J Med Chem 55: 10972-94 (2012)


Article DOI: 10.1021/jm301404a
BindingDB Entry DOI: 10.7270/Q2RJ4KMK
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))
BDBM50400406
PNG
(CHEMBL2177784)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc2N(CCc12)c1ccc(cc1F)-c1cccn1C
Show InChI InChI=1S/C26H30FN5O3/c1-17(2)34-26(33)31-12-8-19(9-13-31)35-25-20-10-14-32(24(20)28-16-29-25)23-7-6-18(15-21(23)27)22-5-4-11-30(22)3/h4-7,11,15-17,19H,8-10,12-14H2,1-3H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 158n/an/an/an/a



GlaxoSmithKline Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells co-expressing 6CRE-luciferase gene after 5 hrs by luciferase reporter gene assay


J Med Chem 55: 10972-94 (2012)


Article DOI: 10.1021/jm301404a
BindingDB Entry DOI: 10.7270/Q2RJ4KMK
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))
BDBM50400407
PNG
(CHEMBL2177783)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc2N(CCc12)c1ccc(cc1F)-c1nccs1
Show InChI InChI=1S/C24H26FN5O3S/c1-15(2)32-24(31)29-9-5-17(6-10-29)33-22-18-7-11-30(21(18)27-14-28-22)20-4-3-16(13-19(20)25)23-26-8-12-34-23/h3-4,8,12-15,17H,5-7,9-11H2,1-2H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 79.4n/an/an/an/a



GlaxoSmithKline Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells co-expressing 6CRE-luciferase gene after 5 hrs by luciferase reporter gene assay


J Med Chem 55: 10972-94 (2012)


Article DOI: 10.1021/jm301404a
BindingDB Entry DOI: 10.7270/Q2RJ4KMK
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))
BDBM50400412
PNG
(CHEMBL2177778)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)Oc1cccc2n(ccc12)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C25H30N2O5S/c1-25(2,3)32-24(28)26-15-12-19(13-16-26)31-23-7-5-6-22-21(23)14-17-27(22)18-8-10-20(11-9-18)33(4,29)30/h5-11,14,17,19H,12-13,15-16H2,1-4H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 631n/an/an/an/a



GlaxoSmithKline Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells co-expressing 6CRE-luciferase gene after 5 hrs by luciferase reporter gene assay


J Med Chem 55: 10972-94 (2012)


Article DOI: 10.1021/jm301404a
BindingDB Entry DOI: 10.7270/Q2RJ4KMK
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))
BDBM50400413
PNG
(CHEMBL2177777)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc2N(CCc12)c1ccc(cc1F)S(C)(=O)=O
Show InChI InChI=1S/C22H27FN4O5S/c1-14(2)31-22(28)26-9-6-15(7-10-26)32-21-17-8-11-27(20(17)24-13-25-21)19-5-4-16(12-18(19)23)33(3,29)30/h4-5,12-15H,6-11H2,1-3H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
MCE
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 50.1n/an/an/an/a



GlaxoSmithKline Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells co-expressing 6CRE-luciferase gene after 5 hrs by luciferase reporter gene assay


J Med Chem 55: 10972-94 (2012)


Article DOI: 10.1021/jm301404a
BindingDB Entry DOI: 10.7270/Q2RJ4KMK
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))
BDBM50315136
PNG
(CHEMBL1092240 | N-(4-(1H-1,2,4-triazol-1-yl)phenyl...)
Show SMILES [O-][N+](=O)c1c(Nc2ccc(cc2)-n2cncn2)ncnc1N1CCC(CC1)Sc1ccccn1
Show InChI InChI=1S/C22H21N9O2S/c32-31(33)20-21(28-16-4-6-17(7-5-16)30-15-23-13-27-30)25-14-26-22(20)29-11-8-18(9-12-29)34-19-3-1-2-10-24-19/h1-7,10,13-15,18H,8-9,11-12H2,(H,25,26,28)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/an/an/a 200n/an/an/an/a



GlaxoSmithKline Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells co-expressing 6CRE-luciferase gene after 5 hrs by luciferase reporter gene assay


J Med Chem 55: 10972-94 (2012)


Article DOI: 10.1021/jm301404a
BindingDB Entry DOI: 10.7270/Q2RJ4KMK
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))
BDBM50400365
PNG
(CHEMBL2181690)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc2N(CCc12)c1ccc(c(F)c1)S(C)=O
Show InChI InChI=1S/C22H27FN4O4S/c1-14(2)30-22(28)26-9-6-16(7-10-26)31-21-17-8-11-27(20(17)24-13-25-21)15-4-5-19(32(3)29)18(23)12-15/h4-5,12-14,16H,6-11H2,1-3H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 631n/an/an/an/a



GlaxoSmithKline Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells co-expressing 6CRE-luciferase gene after 5 hrs by luciferase reporter gene assay


J Med Chem 55: 10972-94 (2012)


Article DOI: 10.1021/jm301404a
BindingDB Entry DOI: 10.7270/Q2RJ4KMK
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))
BDBM50400386
PNG
(CHEMBL2177770)
Show SMILES CC(C)c1noc(n1)N1CCC(CC1)Oc1ncnc2N(CCc12)c1ccc(cc1F)S(C)(=O)=O
Show InChI InChI=1S/C23H27FN6O4S/c1-14(2)20-27-23(34-28-20)29-9-6-15(7-10-29)33-22-17-8-11-30(21(17)25-13-26-22)19-5-4-16(12-18(19)24)35(3,31)32/h4-5,12-15H,6-11H2,1-3H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 79.4n/an/an/an/a



GlaxoSmithKline Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells co-expressing 6CRE-luciferase gene after 5 hrs by luciferase reporter gene assay


J Med Chem 55: 10972-94 (2012)


Article DOI: 10.1021/jm301404a
BindingDB Entry DOI: 10.7270/Q2RJ4KMK
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))
BDBM50400388
PNG
(CHEMBL2177768)
Show SMILES OC1CCN(CC1)C#N
Show InChI InChI=1S/C6H10N2O/c7-5-8-3-1-6(9)2-4-8/h6,9H,1-4H2
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 316n/an/an/an/a



GlaxoSmithKline Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells co-expressing 6CRE-luciferase gene after 5 hrs by luciferase reporter gene assay


J Med Chem 55: 10972-94 (2012)


Article DOI: 10.1021/jm301404a
BindingDB Entry DOI: 10.7270/Q2RJ4KMK
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))
BDBM50400398
PNG
(CHEMBL2181696)
Show SMILES CS(=O)(=O)c1ccc(N2CCc3c2ncnc3OC2CCN(CC2)C(=O)OCCF)c(F)c1
Show InChI InChI=1S/C21H24F2N4O5S/c1-33(29,30)15-2-3-18(17(23)12-15)27-10-6-16-19(27)24-13-25-20(16)32-14-4-8-26(9-5-14)21(28)31-11-7-22/h2-3,12-14H,4-11H2,1H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 501n/an/an/an/a



GlaxoSmithKline Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells co-expressing 6CRE-luciferase gene after 5 hrs by luciferase reporter gene assay


J Med Chem 55: 10972-94 (2012)


Article DOI: 10.1021/jm301404a
BindingDB Entry DOI: 10.7270/Q2RJ4KMK
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))
BDBM50400402
PNG
(CHEMBL2181692)
Show SMILES CCCOC(=O)N1CCC(CC1)Oc1ncnc2N(CCc12)c1ccc(cc1F)S(C)(=O)=O
Show InChI InChI=1S/C22H27FN4O5S/c1-3-12-31-22(28)26-9-6-15(7-10-26)32-21-17-8-11-27(20(17)24-14-25-21)19-5-4-16(13-18(19)23)33(2,29)30/h4-5,13-15H,3,6-12H2,1-2H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 79.4n/an/an/an/a



GlaxoSmithKline Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells co-expressing 6CRE-luciferase gene after 5 hrs by luciferase reporter gene assay


J Med Chem 55: 10972-94 (2012)


Article DOI: 10.1021/jm301404a
BindingDB Entry DOI: 10.7270/Q2RJ4KMK
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))
BDBM50400408
PNG
(CHEMBL2177782)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc2N(CCc12)c1ccc(cc1F)C#N
Show InChI InChI=1S/C22H24FN5O3/c1-14(2)30-22(29)27-8-5-16(6-9-27)31-21-17-7-10-28(20(17)25-13-26-21)19-4-3-15(12-24)11-18(19)23/h3-4,11,13-14,16H,5-10H2,1-2H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 63.1n/an/an/an/a



GlaxoSmithKline Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells co-expressing 6CRE-luciferase gene after 5 hrs by luciferase reporter gene assay


J Med Chem 55: 10972-94 (2012)


Article DOI: 10.1021/jm301404a
BindingDB Entry DOI: 10.7270/Q2RJ4KMK
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))
BDBM50400414
PNG
(CHEMBL2177776)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1cccc2N(CCc12)c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C24H30N2O5S/c1-17(2)30-24(27)25-14-11-19(12-15-25)31-23-6-4-5-22-21(23)13-16-26(22)18-7-9-20(10-8-18)32(3,28)29/h4-10,17,19H,11-16H2,1-3H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 501n/an/an/an/a



GlaxoSmithKline Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells co-expressing 6CRE-luciferase gene after 5 hrs by luciferase reporter gene assay


J Med Chem 55: 10972-94 (2012)


Article DOI: 10.1021/jm301404a
BindingDB Entry DOI: 10.7270/Q2RJ4KMK
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))
BDBM50315136
PNG
(CHEMBL1092240 | N-(4-(1H-1,2,4-triazol-1-yl)phenyl...)
Show SMILES [O-][N+](=O)c1c(Nc2ccc(cc2)-n2cncn2)ncnc1N1CCC(CC1)Sc1ccccn1
Show InChI InChI=1S/C22H21N9O2S/c32-31(33)20-21(28-16-4-6-17(7-5-16)30-15-23-13-27-30)25-14-26-22(20)29-11-8-18(9-12-29)34-19-3-1-2-10-24-19/h1-7,10,13-15,18H,8-9,11-12H2,(H,25,26,28)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/an/an/a 130n/an/an/an/a



GlaxoSmithKline Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at GPR119 receptor by cell based cAMP assay


J Med Chem 55: 10972-94 (2012)


Article DOI: 10.1021/jm301404a
BindingDB Entry DOI: 10.7270/Q2RJ4KMK
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))
BDBM50400366
PNG
(CHEMBL2181689)
Show SMILES CSc1ccc(cc1F)N1CCc2c1ncnc2OC1CCN(CC1)C(=O)OC(C)C
Show InChI InChI=1S/C22H27FN4O3S/c1-14(2)29-22(28)26-9-6-16(7-10-26)30-21-17-8-11-27(20(17)24-13-25-21)15-4-5-19(31-3)18(23)12-15/h4-5,12-14,16H,6-11H2,1-3H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 398n/an/an/an/a



GlaxoSmithKline Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells co-expressing 6CRE-luciferase gene after 5 hrs by luciferase reporter gene assay


J Med Chem 55: 10972-94 (2012)


Article DOI: 10.1021/jm301404a
BindingDB Entry DOI: 10.7270/Q2RJ4KMK
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))
BDBM50400374
PNG
(CHEMBL2181681)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc2N(CCc12)c1ccc(cn1)S(C)(=O)=O
Show InChI InChI=1S/C21H27N5O5S/c1-14(2)30-21(27)25-9-6-15(7-10-25)31-20-17-8-11-26(19(17)23-13-24-20)18-5-4-16(12-22-18)32(3,28)29/h4-5,12-15H,6-11H2,1-3H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 126n/an/an/an/a



GlaxoSmithKline Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells co-expressing 6CRE-luciferase gene after 5 hrs by luciferase reporter gene assay


J Med Chem 55: 10972-94 (2012)


Article DOI: 10.1021/jm301404a
BindingDB Entry DOI: 10.7270/Q2RJ4KMK
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))
BDBM50400375
PNG
(CHEMBL2181680)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc2N(C(C)Cc12)c1ccc(cc1F)S(C)(=O)=O
Show InChI InChI=1S/C23H29FN4O5S/c1-14(2)32-23(29)27-9-7-16(8-10-27)33-22-18-11-15(3)28(21(18)25-13-26-22)20-6-5-17(12-19(20)24)34(4,30)31/h5-6,12-16H,7-11H2,1-4H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a>1.00E+4n/an/an/an/a



GlaxoSmithKline Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells co-expressing 6CRE-luciferase gene after 5 hrs by luciferase reporter gene assay


J Med Chem 55: 10972-94 (2012)


Article DOI: 10.1021/jm301404a
BindingDB Entry DOI: 10.7270/Q2RJ4KMK
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))
BDBM50400385
PNG
(CHEMBL2177771)
Show SMILES CS(=O)(=O)c1ccc(N2CCc3c2ncnc3OC2CCN(CC2)C2=NCCCN2)c(F)c1 |t:27|
Show InChI InChI=1S/C22H27FN6O3S/c1-33(30,31)16-3-4-19(18(23)13-16)29-12-7-17-20(29)26-14-27-21(17)32-15-5-10-28(11-6-15)22-24-8-2-9-25-22/h3-4,13-15H,2,5-12H2,1H3,(H,24,25)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 2.00E+3n/an/an/an/a



GlaxoSmithKline Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells co-expressing 6CRE-luciferase gene after 5 hrs by luciferase reporter gene assay


J Med Chem 55: 10972-94 (2012)


Article DOI: 10.1021/jm301404a
BindingDB Entry DOI: 10.7270/Q2RJ4KMK
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))
BDBM50400370
PNG
(CHEMBL2181685)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc2N(CCc12)c1cccnc1C
Show InChI InChI=1S/C21H27N5O3/c1-14(2)28-21(27)25-10-6-16(7-11-25)29-20-17-8-12-26(19(17)23-13-24-20)18-5-4-9-22-15(18)3/h4-5,9,13-14,16H,6-8,10-12H2,1-3H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a>1.00E+4n/an/an/an/a



GlaxoSmithKline Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells co-expressing 6CRE-luciferase gene after 5 hrs by luciferase reporter gene assay


J Med Chem 55: 10972-94 (2012)


Article DOI: 10.1021/jm301404a
BindingDB Entry DOI: 10.7270/Q2RJ4KMK
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))
BDBM50400376
PNG
(CHEMBL2181679)
Show SMILES CC(C)OC(=O)N1CCC(CC1)S(=O)(=O)c1ncnc2N(CCc12)c1ccc(cc1F)S(C)(=O)=O
Show InChI InChI=1S/C22H27FN4O6S2/c1-14(2)33-22(28)26-9-6-15(7-10-26)35(31,32)21-17-8-11-27(20(17)24-13-25-21)19-5-4-16(12-18(19)23)34(3,29)30/h4-5,12-15H,6-11H2,1-3H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a>1.00E+4n/an/an/an/a



GlaxoSmithKline Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells co-expressing 6CRE-luciferase gene after 5 hrs by luciferase reporter gene assay


J Med Chem 55: 10972-94 (2012)


Article DOI: 10.1021/jm301404a
BindingDB Entry DOI: 10.7270/Q2RJ4KMK
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))
BDBM50400387
PNG
(CHEMBL2177769)
Show SMILES CC(C)c1noc(n1)N1CCC(O)CC1
Show InChI InChI=1S/C10H17N3O2/c1-7(2)9-11-10(15-12-9)13-5-3-8(14)4-6-13/h7-8,14H,3-6H2,1-2H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 50.1n/an/an/an/a



GlaxoSmithKline Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells co-expressing 6CRE-luciferase gene after 5 hrs by luciferase reporter gene assay


J Med Chem 55: 10972-94 (2012)


Article DOI: 10.1021/jm301404a
BindingDB Entry DOI: 10.7270/Q2RJ4KMK
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))
BDBM50400411
PNG
(CHEMBL2177779)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)Oc1cccc2N(CCc12)c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C25H32N2O5S/c1-25(2,3)32-24(28)26-15-12-19(13-16-26)31-23-7-5-6-22-21(23)14-17-27(22)18-8-10-20(11-9-18)33(4,29)30/h5-11,19H,12-17H2,1-4H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 158n/an/an/an/a



GlaxoSmithKline Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells co-expressing 6CRE-luciferase gene after 5 hrs by luciferase reporter gene assay


J Med Chem 55: 10972-94 (2012)


Article DOI: 10.1021/jm301404a
BindingDB Entry DOI: 10.7270/Q2RJ4KMK
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))
BDBM50400373
PNG
(CHEMBL2181682)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc2N(CCc12)c1ccc(nc1)S(C)(=O)=O
Show InChI InChI=1S/C21H27N5O5S/c1-14(2)30-21(27)25-9-6-16(7-10-25)31-20-17-8-11-26(19(17)23-13-24-20)15-4-5-18(22-12-15)32(3,28)29/h4-5,12-14,16H,6-11H2,1-3H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 251n/an/an/an/a



GlaxoSmithKline Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells co-expressing 6CRE-luciferase gene after 5 hrs by luciferase reporter gene assay


J Med Chem 55: 10972-94 (2012)


Article DOI: 10.1021/jm301404a
BindingDB Entry DOI: 10.7270/Q2RJ4KMK
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))
BDBM50400380
PNG
(CHEMBL2181675)
Show SMILES CNc1nc2N(CCc2c(OC2CCN(CC2)C(=O)OC(C)C)n1)c1ccc(cc1F)S(C)(=O)=O
Show InChI InChI=1S/C23H30FN5O5S/c1-14(2)33-23(30)28-10-7-15(8-11-28)34-21-17-9-12-29(20(17)26-22(25-3)27-21)19-6-5-16(13-18(19)24)35(4,31)32/h5-6,13-15H,7-12H2,1-4H3,(H,25,26,27)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a>1.00E+4n/an/an/an/a



GlaxoSmithKline Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells co-expressing 6CRE-luciferase gene after 5 hrs by luciferase reporter gene assay


J Med Chem 55: 10972-94 (2012)


Article DOI: 10.1021/jm301404a
BindingDB Entry DOI: 10.7270/Q2RJ4KMK
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))
BDBM50400384
PNG
(CHEMBL2177772)
Show SMILES Cc1nc2N(CCc2c(OC2CCN(CC2)C(=O)OC(C)(C)C)n1)c1ccc(cc1F)S(C)(=O)=O
Show InChI InChI=1S/C24H31FN4O5S/c1-15-26-21-18(10-13-29(21)20-7-6-17(14-19(20)25)35(5,31)32)22(27-15)33-16-8-11-28(12-9-16)23(30)34-24(2,3)4/h6-7,14,16H,8-13H2,1-5H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 126n/an/an/an/a



GlaxoSmithKline Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells co-expressing 6CRE-luciferase gene after 5 hrs by luciferase reporter gene assay


J Med Chem 55: 10972-94 (2012)


Article DOI: 10.1021/jm301404a
BindingDB Entry DOI: 10.7270/Q2RJ4KMK
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))
BDBM50400393
PNG
(CHEMBL2177763)
Show SMILES CS(=O)(=O)c1ccc(N2CCc3c2ncnc3OC2CCN(CC2)C(=S)Sc2ccccc2)c(F)c1
Show InChI InChI=1S/C25H25FN4O3S3/c1-36(31,32)19-7-8-22(21(26)15-19)30-14-11-20-23(30)27-16-28-24(20)33-17-9-12-29(13-10-17)25(34)35-18-5-3-2-4-6-18/h2-8,15-17H,9-14H2,1H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 12.6n/an/an/an/a



GlaxoSmithKline Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells co-expressing 6CRE-luciferase gene after 5 hrs by luciferase reporter gene assay


J Med Chem 55: 10972-94 (2012)


Article DOI: 10.1021/jm301404a
BindingDB Entry DOI: 10.7270/Q2RJ4KMK
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))
BDBM50400401
PNG
(CHEMBL2181693)
Show SMILES CCCCOC(=O)N1CCC(CC1)Oc1ncnc2N(CCc12)c1ccc(cc1F)S(C)(=O)=O
Show InChI InChI=1S/C23H29FN4O5S/c1-3-4-13-32-23(29)27-10-7-16(8-11-27)33-22-18-9-12-28(21(18)25-15-26-22)20-6-5-17(14-19(20)24)34(2,30)31/h5-6,14-16H,3-4,7-13H2,1-2H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 50.1n/an/an/an/a



GlaxoSmithKline Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells co-expressing 6CRE-luciferase gene after 5 hrs by luciferase reporter gene assay


J Med Chem 55: 10972-94 (2012)


Article DOI: 10.1021/jm301404a
BindingDB Entry DOI: 10.7270/Q2RJ4KMK
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))
BDBM50400403
PNG
(CHEMBL2177787)
Show SMILES CCOC(=O)N1CCC(CC1)Oc1ncnc2N(CCc12)c1ccc(cc1F)S(C)(=O)=O
Show InChI InChI=1S/C21H25FN4O5S/c1-3-30-21(27)25-9-6-14(7-10-25)31-20-16-8-11-26(19(16)23-13-24-20)18-5-4-15(12-17(18)22)32(2,28)29/h4-5,12-14H,3,6-11H2,1-2H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 251n/an/an/an/a



GlaxoSmithKline Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells co-expressing 6CRE-luciferase gene after 5 hrs by luciferase reporter gene assay


J Med Chem 55: 10972-94 (2012)


Article DOI: 10.1021/jm301404a
BindingDB Entry DOI: 10.7270/Q2RJ4KMK
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))
BDBM50400404
PNG
(CHEMBL2177786)
Show SMILES COC(=O)N1CCC(CC1)Oc1ncnc2N(CCc12)c1ccc(cc1F)S(C)(=O)=O
Show InChI InChI=1S/C20H23FN4O5S/c1-29-20(26)24-8-5-13(6-9-24)30-19-15-7-10-25(18(15)22-12-23-19)17-4-3-14(11-16(17)21)31(2,27)28/h3-4,11-13H,5-10H2,1-2H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 316n/an/an/an/a



GlaxoSmithKline Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells co-expressing 6CRE-luciferase gene after 5 hrs by luciferase reporter gene assay


J Med Chem 55: 10972-94 (2012)


Article DOI: 10.1021/jm301404a
BindingDB Entry DOI: 10.7270/Q2RJ4KMK
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))
BDBM50400390
PNG
(CHEMBL2177766)
Show SMILES CN(C)S(=O)(=O)N1CCC(CC1)Oc1ncnc2N(CCc12)c1ccc(cc1F)S(C)(=O)=O
Show InChI InChI=1S/C20H26FN5O5S2/c1-24(2)33(29,30)25-9-6-14(7-10-25)31-20-16-8-11-26(19(16)22-13-23-20)18-5-4-15(12-17(18)21)32(3,27)28/h4-5,12-14H,6-11H2,1-3H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 398n/an/an/an/a



GlaxoSmithKline Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells co-expressing 6CRE-luciferase gene after 5 hrs by luciferase reporter gene assay


J Med Chem 55: 10972-94 (2012)


Article DOI: 10.1021/jm301404a
BindingDB Entry DOI: 10.7270/Q2RJ4KMK
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))
BDBM50400392
PNG
(CHEMBL2177764)
Show SMILES CCS(=O)(=O)N1CCC(CC1)Oc1ncnc2N(CCc12)c1ccc(cc1F)S(C)(=O)=O
Show InChI InChI=1S/C20H25FN4O5S2/c1-3-32(28,29)24-9-6-14(7-10-24)30-20-16-8-11-25(19(16)22-13-23-20)18-5-4-15(12-17(18)21)31(2,26)27/h4-5,12-14H,3,6-11H2,1-2H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 1.58E+3n/an/an/an/a



GlaxoSmithKline Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells co-expressing 6CRE-luciferase gene after 5 hrs by luciferase reporter gene assay


J Med Chem 55: 10972-94 (2012)


Article DOI: 10.1021/jm301404a
BindingDB Entry DOI: 10.7270/Q2RJ4KMK
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%